@article{RingersBialonskiEgeetal.2023,
  author    = {Ringers, Christa and Bialonski, Stephan and Ege, Mert and Solovev, Anton and Hansen, Jan Niklas and Jeong, Inyoung and Friedrich, Benjamin M. and Jurisch-Yaksi, Nathalie},
  title     = {Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia},
  series = {eLife},
  volume    = {12},
  journal   = {eLife},
  publisher = {eLife Sciences Publications},
  issn      = {2050-084X},
  doi       = {10.7554/eLife.77701},
  pages     = {27 Seiten},
  year      = {2023},
  abstract  = {Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to exhibit a remarkable coordination of their beat in the form of traveling metachronal waves, a phenomenon which supposedly enhances fluid transport. Yet, how cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine experiments, novel analysis tools, and theory to address this knowledge gap. To investigate collective dynamics of cilia, we studied zebrafish multiciliated epithelia in the nose and the brain. We focused mainly on the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Even though synchronization is local only, we observed global patterns of traveling metachronal waves across the zebrafish multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right noses, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions, i.e., cilia colliding with each other, and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment coincide and generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1030 -- 1031},
  year      = {2004},
  language  = {en}
}
@article{AsanteAsamaniKleefeldWade2020,
  author    = {Asante-Asamani, E.O. and Kleefeld, Andreas and Wade, B.A.},
  title     = {A second-order exponential time differencing scheme for non-linear reaction-diffusion systems with dimensional splitting},
  series = {Journal of Computational Physics},
  volume    = {415},
  journal   = {Journal of Computational Physics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9991},
  doi       = {10.1016/j.jcp.2020.109490},
  year      = {2020},
  abstract  = {A second-order L-stable exponential time-differencing (ETD) method is developed by combining an ETD scheme with approximating the matrix exponentials by rational functions having real distinct poles (RDP), together with a dimensional splitting integrating factor technique. A variety of non-linear reaction-diffusion equations in two and three dimensions with either Dirichlet, Neumann, or periodic boundary conditions are solved with this scheme and shown to outperform a variety of other second-order implicit-explicit schemes. An additional performance boost is gained through further use of basic parallelization techniques.},
  language  = {en}
}
@inproceedings{DigelLeimenaDachwaldetal.2010,
  author    = {Digel, Ilya and Leimena, W. and Dachwald, Bernd and Linder, Peter and Porst, Dariusz and Kayser, Peter and Funke, O. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {In-situ biological decontamination of an ice melting probe : [abstract]},
  year      = {2010},
  abstract  = {The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.},
  subject      = {Sonde},
  language  = {en}
}
@article{RauschHarbrechtKahmannetal.2020,
  author    = {Rausch, Valentin and Harbrecht, Andreas and Kahmann, Stephanie Lucina and Fenten, Thomas and Jovanovic, Nebojsa and Hackl, Michael and M{\"u}ller, Lars P. and Staat, Manfred and Wegmann, Kilian},
  title     = {Osteosynthesis of Phalangeal Fractures: Biomechanical Comparison of Kirschner Wires, Plates, and Compression Screws},
  series = {The Journal of Hand Surgery},
  volume    = {45},
  journal   = {The Journal of Hand Surgery},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0363-5023},
  doi       = {10.1016/j.jhsa.2020.04.010},
  pages     = {987.e1 -- 987.e8},
  year      = {2020},
  abstract  = {Purpose The aim of this study was to compare several osteosynthesis techniques (intramedullary headless compression screws, T-plates, and Kirschner wires) for distal epiphyseal fractures of proximal phalanges in a human cadaveric model. Methods A total of 90 proximal phalanges from 30 specimens (index, ring, and middle fingers) were used for this study. After stripping off all soft tissue, a transverse distal epiphyseal fracture was simulated at the proximal phalanx. The 30 specimens were randomly assigned to 1 fixation technique (30 per technique), either a 3.0-mm intramedullary headless compression screw, locking plate fixation with a 2.0-mm T-plate, or 2 oblique 1.0-mm Kirschner wires. Displacement analysis (bending, distraction, and torsion) was performed using optical tracking of an applied random speckle pattern after osteosynthesis. Biomechanical testing was performed with increasing cyclic loading and with cyclic load to failure using a biaxial torsion-tension testing machine. Results Cannulated intramedullary compression screws showed significantly less displacement at the fracture site in torsional testing. Furthermore, screws were significantly more stable in bending testing. Kirschner wires were significantly less stable than plating or screw fixation in any cyclic load to failure test setup. Conclusions Intramedullary compression screws are a highly stable alternative in the treatment of transverse distal epiphyseal phalangeal fractures. Kirschner wires seem to be inferior regarding displacement properties and primary stability. Clinical relevance Fracture fixation of phalangeal fractures using plate osteosynthesis may have the advantage of a very rigid reduction, but disadvantages such as stiffness owing to the more invasive surgical approach and soft tissue irritation should be taken into account. Headless compression screws represent a minimally invasive choice for fixation with good biomechanical properties.},
  language  = {en}
}
@inproceedings{StaatHeitzer2000,
  author    = {Staat, Manfred and Heitzer, Michael},
  title     = {Direct static FEM approach to limit and shakedown analysis},
  year      = {2000},
  abstract  = {Safety and reliability of structures may be assessed indirectly by stress distributions. Limit and shakedown theorems are simplified but exact methods of plasticity that provide safety factors directly in the loading space. These theorems may be used for a direct definition of the limit state function for failure by plastic collapse or by inadaptation. In a FEM formulation the limit state function is obtained from a nonlinear optimization problem. This direct approach reduces considerably the necessary knowledge of uncertain technological input data, the computing time, and the numerical error. Moreover, the direct way leads to highly effective and precise reliability analyses. The theorems are implemented into a general purpose FEM program in a way capable of large-scale analysis.},
  subject      = {Einspielen <Werkstoff>},
  language  = {en}
}
@article{MuschallikKippReckeretal.2020,
  author    = {Muschallik, Lukas and Kipp, Carina Ronja and Recker, Inga and Bongaerts, Johannes and Pohl, Martina and Gelissen, Melanie and Sch{\"o}ning, Michael Josef and Selmer, Thorsten and Siegert, Petra},
  title     = {Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase},
  series = {Journal of Biotechnology},
  volume    = {202},
  journal   = {Journal of Biotechnology},
  number    = {Vol. 324},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {2590-1559},
  doi       = {10.1016/j.jbiotec.2020.09.016},
  pages     = {61 -- 70},
  year      = {2020},
  abstract  = {The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.},
  language  = {en}
}
@article{HunkerGossmannRamanetal.2021,
  author    = {Hunker, Jan L. and Gossmann, Matthias and Raman, Aravind Hariharan and Linder, Peter},
  title     = {Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility},
  series = {Journal of Pharmacological and Toxicological Methods},
  volume    = {111},
  journal   = {Journal of Pharmacological and Toxicological Methods},
  number    = {Article number 107044},
  publisher = {Elsevier},
  address   = {New York},
  issn      = {1056-8719},
  doi       = {10.1016/j.vascn.2021.107044},
  year      = {2021},
  language  = {en}
}
@book{ArtmannTemizArtmannZhubanovaetal.2018,
  author    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  title     = {Biological, physical and technical basics of cell engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7903-0},
  pages     = {xxiv, 481 Seiten ; Illustrationen, Diagramme},
  year      = {2018},
  language  = {en}
}
@article{Staat2005,
  author    = {Staat, Manfred},
  title     = {Local and global collapse pressure of longitudinally flawed pipes and cylindrical vessels},
  year      = {2005},
  abstract  = {Limit loads can be calculated with the finite element method (FEM) for any component, defect geometry, and loading. FEM suggests that published long crack limit formulae for axial defects under-estimate the burst pressure for internal surface defects in thick pipes while limit loads are not conservative for deep cracks and for pressure loaded crack-faces. Very deep cracks have a residual strength, which is modelled by a global collapse load. These observations are combined to derive new analytical local and global collapse loads. The global collapse loads are close to FEM limit analyses for all crack dimensions.},
  subject      = {Finite-Elemente-Methode},
  language  = {en}
}
@inproceedings{TranStaatKreissig2007,
  author    = {Tran, Thanh Ngoc and Staat, Manfred and Kreißig, R.},
  title     = {Finite element shakedown and limit reliability analysis of thin shells},
  year      = {2007},
  abstract  = {A procedure for the evaluation of the failure probability of elastic-plastic thin shell structures is presented. The procedure involves a deterministic limit and shakedown analysis for each probabilistic iteration which is based on the kinematical approach and the use the exact Ilyushin yield surface. Based on a direct definition of the limit state function, the non-linear problems may be efficiently solved by using the First and Second Order Reliabiblity Methods (Form/SORM). This direct approach reduces considerably the necessary knowledge of uncertain technological input data, computing costs and the numerical error. In: Computational plasticity / ed. by Eugenio Onate. Dordrecht: Springer 2007. VII, 265 S. (Computational Methods in Applied Sciences ; 7) (COMPLAS IX. Part 1 . International Center for Numerical Methods in Engineering (CIMNE)). ISBN 978-1-402-06576-7 S. 186-189},
  subject      = {Finite-Elemente-Methode},
  language  = {en}
}
@article{Staat2004,
  author    = {Staat, Manfred},
  title     = {Plastic collapse analysis of longitudinally flawed pipes and vessels},
  year      = {2004},
  abstract  = {Improved collapse loads of thick-walled, crack containing pipes and vessels are suggested. Very deep cracks have a residual strength which is better modelled by a global limit load. In all burst tests, the ductility of pressure vessel steels was sufficiently high whereby the burst pressure could be predicted by limit analysis with no need to apply fracture mechanics. The relative prognosis error increases however, for long and deep defects due to uncertainties of geometry and strength data.},
  subject      = {Druckbeh{\"a}lter},
  language  = {en}
}
@inproceedings{DuongStaat2014,
  author    = {Duong, Minh Tuan and Staat, Manfred},
  title     = {A face-based smoothed finite element method for hyperelastic models and tissue growth},
  series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  editor    = {Onate, E.},
  organization    = {World Congress on Computational Mechanics <11, 2014, Barcelona>},
  pages     = {1 -- 12},
  year      = {2014},
  language  = {en}
}
@inproceedings{Staat2003,
  author    = {Staat, Manfred},
  title     = {Design by Analysis of Pressure Components by non-linear Optimization},
  year      = {2003},
  abstract  = {This paper presents the direct route to Design by Analysis (DBA) of the new European pressure vessel standard in the language of limit and shakedown analysis (LISA). This approach leads to an optimization problem. Its solution with Finite Element Analysis is demonstrated for some examples from the DBA-Manual. One observation from the examples is, that the optimisation approach gives reliable and close lower bound solutions leading to simple and optimised design decision.},
  language  = {en}
}
@article{StaatSchwartzLangetal.2003,
  author    = {Staat, Manfred and Schwartz, M. and Lang, H. and Wirtz, K. and Heitzer, M.},
  title     = {Design by Analysis of Pressure Components by non-linear Optimization},
  series = {The 10th International Conference on Pressure Vessel Technology, July 7-10, 2003, Vienna, Austria, Proceedings ICPVT-10 / Zeman, J. L. [ed]},
  journal   = {The 10th International Conference on Pressure Vessel Technology, July 7-10, 2003, Vienna, Austria, Proceedings ICPVT-10 / Zeman, J. L. [ed]},
  publisher = {{\"O}GS, {\"O}sterreichische Gesellschaft f{\"u}r Schweißtechnik},
  address   = {Wien},
  isbn      = {3950152814},
  pages     = {59 -- 65},
  year      = {2003},
  language  = {en}
}
@article{StaatHeitzer2002,
  author    = {Staat, Manfred and Heitzer, M.},
  title     = {Limit and Shakedown Analysis with Uncertain Data},
  series = {Stochastic optimization techniques : numerical methods and technical applications / Marti, K. [ed]},
  journal   = {Stochastic optimization techniques : numerical methods and technical applications / Marti, K. [ed]},
  publisher = {Springer},
  address   = {Heidelberg},
  isbn      = {3-540-42889-5},
  pages     = {241 -- 254},
  year      = {2002},
  language  = {en}
}
@article{JablonskiMuenstermannNorketal.2021,
  author    = {Jablonski, Melanie and M{\"u}nstermann, Felix and Nork, Jasmina and Molinnus, Denise and Muschallik, Lukas and Bongaerts, Johannes and Wagner, Torsten and Keusgen, Michael and Siegert, Petra and Sch{\"o}ning, Michael Josef},
  title     = {Capacitive field-effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000765},
  pages     = {7 Seiten},
  year      = {2021},
  abstract  = {An acetoin biosensor based on a capacitive electrolyte-insulator-semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance-voltage, and constant capacitance methods, respectively.},
  language  = {en}
}
@article{StadlerZerlinDigeletal.2008,
  author    = {Stadler, Andreas M. and Zerlin, Kay and Digel, Ilya and B{\"u}ldt, Georg and Zaccai, Guiseppe and Artmann, Gerhard},
  title     = {Dynamics and interactions of hemoglobin in red blood cells},
  series = {Tissue Engineering Part A. 14 (2008), H. 5},
  journal   = {Tissue Engineering Part A. 14 (2008), H. 5},
  isbn      = {1937-3341},
  pages     = {724 -- 724},
  year      = {2008},
  language  = {en}
}
@article{StaatBaroudTopcuetal.2008,
  author    = {Staat, Manfred and Baroud, G. and Topcu, M. and Sponagel, Stefan},
  title     = {Soft Materials in Technology and Biology - Characteristics, Properties, and Parameter Identification},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {253 -- 315},
  year      = {2008},
  language  = {en}
}
@article{AkimbekovDigelTastambeketal.2013,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Tastambek, K. T. and Zhubanova, A. A.},
  title     = {Biocompatibility of carbonized rice husk with a rat heart cells line H9c2},
  series = {Experimental Biology},
  volume    = {59},
  journal   = {Experimental Biology},
  number    = {3/1},
  issn      = {1563-0218},
  pages     = {23 -- 25},
  year      = {2013},
  language  = {en}
}