@inproceedings{WuttkeButenwegRosinetal.2019,
  author    = {Wuttke, Claudia and Butenweg, Christoph and Rosin, Julia and Kubalski, Thomas},
  title     = {Verbesserte seismische Nachweiskonzepte f{\"u}r Mauerwerksbauten in deutschen Erdbebengebieten},
  series = {Adam, Christoph (Hrsg.) ; Univ. Innsbruck: 16. D-A-CH Tagung Erdbebeningenieurwesen \& Baudynamik 2019 : 26. und 27. September 2019, Innsbruck},
  booktitle = {Adam, Christoph (Hrsg.) ; Univ. Innsbruck: 16. D-A-CH Tagung Erdbebeningenieurwesen \& Baudynamik 2019 : 26. und 27. September 2019, Innsbruck},
  address   = {Innsbruck},
  isbn      = {978-3-200-06454-6},
  pages     = {713 -- 722},
  year      = {2019},
  language  = {de}
}
@inproceedings{GrundmannBauerBodenetal.2019,
  author    = {Grundmann, Jan Thimo and Bauer, Waldemar and Boden, Ralf Christian and Ceriotti, Matteo and Cordero, Federico and Dachwald, Bernd and Dumont, Etienne and Grimm, Christian D. and Hercik, D. and Herique, A. and Ho, Tra-Mi and Jahnke, Rico and Kofman, Wlodek and Lange, Caroline and Lichtenheldt, Roy and McInnes, Colin R. and Mikschl, Tobias and Montenegro, Sergio and Moore, Iain and Pelivan, Ivanka and Peloni, Alessandro and Plettenmeier, Dirk and Quantius, Dominik and Reershemius, Siebo and Renger, Thomas and Riemann, Johannes and Rogez, Yves and Ruffer, Michael and Sasaki, Kaname and Schmitz, Nicole and Seboldt, Wolfgang and Seefeldt, Patric and Spietz, Peter and Spr{\"o}witz, Tom and Sznajder, Maciej and Toth, Norbert and Viavattene, Giulia and Wejmo, Elisabet and Wolff, Friederike and Ziach, Christian},
  title     = {Responsive exploration and asteroid characterization through integrated solar sail and lander development using small spacecraft technologies},
  series = {IAA Planetary Defense Conference},
  booktitle = {IAA Planetary Defense Conference},
  year      = {2019},
  abstract  = {In parallel to the evolution of the Planetary Defense Conference, the exploration of small solar system bodies has advanced from fast fly-bys on the sidelines of missions to the planets to the implementation of dedicated sample-return and in-situ analysis missions. Spacecraft of all sizes have landed, touch-and-go sampled, been gently beached, or impacted at hypervelocity on asteroid and comet surfaces. More have flown by close enough to image their surfaces in detail or sample their immediate environment, often as part of an extended or re-purposed mission. And finally, full-scale planetary defense experiment missions are in the making. Highly efficient low-thrust propulsion is increasingly applied beyond commercial use also in mainstream and flagship science missions, in combination with gravity assist propulsion. Another development in the same years is the growth of small spacecraft solutions, not in size but in numbers and individual capabilities. The on-going NASA OSIRIS-REx and JAXA HAYABUSA2 missions exemplify the trend as well as the upcoming NEA SCOUT mission or the landers MINERVA-II and MASCOT recently deployed on Ryugu. We outline likely as well as possible and efficient routes of continuation of all these developments towards a propellant-less and highly efficient class of spacecraft for small solar system body exploration: small spacecraft solar sails designed for carefree handling and equipped with carried landers and application modules, for all asteroid user communities -planetary science, planetary defence, and in-situ resource utilization. This projection builds on the experience gained in the development of deployable membrane structures leading up to the successful ground deployment test of a (20 m)² solar sail at DLR Cologne and in the 20 years since. It draws on the background of extensive trajectory optimization studies, the qualified technology of the DLR GOSSAMER-1 deployment demonstrator, and the MASCOT asteroid lander. These enable 'now-term' as well as near-term hardware solutions, and thus responsive fast-paced development. Mission types directly applicable to planetary defense include: single and Multiple NEA Rendezvous ((M)NR) for mitigation precursor, target monitoring and deflection follow-up tasks; sail-propelled head-on retrograde kinetic impactors (RKI) for mitigation; and deployable membrane based methods to modify the asteroid's properties or interact with it. The DLR-ESTEC GOSSAMER Roadmap initiated studies of missions uniquely feasible with solar sails such as Displaced L1 (DL1) space weather advance warning and monitoring and Solar Polar Orbiter (SPO) delivery which demonstrate the capability of near-term solar sails to achieve NEA rendezvous in any kind of orbit, from Earth-coorbital to extremely inclined and even retrograde orbits. For those mission types using separable payloads, such as SPO, (M)NR and RKI, design concepts can be derived from the separable Boom Sail Deployment Units characteristic of DLR GOSSAMER solar sail technology, nanolanders like MASCOT, or microlanders like the JAXA-DLR Jupiter Trojan Asteroid Lander for the OKEANOS mission which can shuttle from the sail to the asteroids visited and enable multiple NEA sample-return missions. These are an ideal match for solar sails in micro-spacecraft format whose launch configurations are compatible with ESPA and ASAP secondary payload platforms.},
  language  = {en}
}
@inproceedings{GrundmannBauerBodenetal.2019,
  author    = {Grundmann, Jan Thimo and Bauer, Waldemar and Boden, Ralf Christian and Ceriotti, Matteo and Cordero, Federico and Dachwald, Bernd and Dumont, Etienne and Grimm, Christian D. and Hercik, D. and Herique, A. and Ho, Tra-Mi and Jahnke, Rico and Kofman, Wlodek and Lange, Caroline and Lichtenheldt, Roy and McInnes, Colin R. and Mikschl, Tobias and Mikulz, Eugen and Montenegro, Sergio and Moore, Iain and Pelivan, Ivanka and Peloni, Alessandro and Plettemeier, Dirk and Quantius, Dominik and Reershemius, Siebo and Renger, Thomas and Riemann, Johannes and Rogez, Yves and Ruffer, Michael and Sasaki, Kaname and Schmitz, Nicole and Seboldt, Wolfgang and Seefeldt, Patric and Spietz, Peter and Spr{\"o}witz, Tom and Sznajder, Maciej and Toth, Norbert and Viavattene, Giulia and Wejmo, Elisabet and Wolff, Friederike and Ziach, Christian},
  title     = {Responsive integrated small spacecraft solar sail and payload design concepts and missions},
  series = {Conference: 5th International Symposium on Solar Sailing (ISSS 2019)},
  booktitle = {Conference: 5th International Symposium on Solar Sailing (ISSS 2019)},
  year      = {2019},
  abstract  = {Asteroid mining has the potential to greatly reduce the cost of in-space manufacturing, production of propellant for space transportation and consumables for crewed spacecraft, compared to launching the required resources from Earth's deep gravity well. This paper discusses the top-level mission architecture and trajectory design for these resource-return missions, comparing high-thrust trajectories with continuous low-thrust solar-sail trajectories. This work focuses on maximizing the economic Net Present Value, which takes the time-cost of finance into account and therefore balances the returned resource mass and mission duration. The different propulsion methods will then be compared in terms of maximum economic return, sets of attainable target asteroids, and mission flexibility. This paper provides one more step towards making commercial asteroid mining an economically viable reality by integrating trajectory design, propulsion technology and economic modelling.},
  language  = {en}
}
@inproceedings{WolfBartonHerrmannetal.2019,
  author    = {Wolf, Martin and Barton, Thomas and Herrmann, Frank and Meister, Vera G. and M{\"u}ller, Christian and Seel, Christian},
  title     = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung vom 15.09.2019 bis 18.09.2019 an der Fachhochschule f{\"u}r Angewandte Wissenschaften Aachen / hrsg. von Martin R. Wolf, Thomas Barton, Frank Herrmann, Vera G. Meister, Christian M{\"u}ller, Christian Seel},
  publisher = {mana-Buch},
  address   = {Heide},
  isbn      = {978-3-944330-62-4},
  doi       = {10.15771/978-3-944330-62-4},
  url       = {http://nbn-resolving.de/urn:nbn:de:kobv:526-opus4-13026},
  pages     = {261 Seiten},
  year      = {2019},
  abstract  = {Tagungsbeitr{\"a}ge aus den Bereichen Projektmanagement, Didaktik in der Wirtschaftsinformatik, IT-Sicherheit, Anwendungsf{\"a}lle, Reifegradmodelle, Plattformen f{\"u}r Gesch{\"a}ftsprozesse und Prototypen.},
  language  = {de}
}
@inproceedings{MollKoehlerWolf2019,
  author    = {Moll, Florian and K{\"o}hler, Klemens and Wolf, Martin},
  title     = {Konzeption von IT-Sicherheitsl{\"o}sungen unter ethischen Gesichtspunkten am Beispiel einer Monitoring-App f{\"u}r mobile Endger{\"a}te},
  series = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung},
  booktitle = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung},
  publisher = {mana-Buch},
  address   = {Heide},
  isbn      = {978-3-944330-62-4},
  pages     = {61 -- 72},
  year      = {2019},
  abstract  = {Die steigende Popularit{\"a}t von mobilen Endger{\"a}ten im privaten und gesch{\"a}ftlichen Umfeld geht mit einem Anstieg an Sicherheitsl{\"u}cken und somit potentiellen Angriffsfl{\"a}chen einher. Als ein Element der technischen und organisatorischen Maßnahmen zum Schutz eines Netzwerkes k{\"o}nnen Monitoring-Apps dienen, die unerw{\"u}nschtes Verhalten und Angriffe erkennen. Die automatisierte {\"U}berwachung von Endger{\"a}ten ist jedoch rechtlich und ethisch komplex. Dies in Kombination mit einer hohen Sensibilit{\"a}t der Nutzer und Nutzerinnen dieser Ger{\"a}te in Bezug auf Privatsph{\"a}re, kann zu einer geringen Akzeptanz und Compliance f{\"u}hren. Eine datenschutzrechtlich und ethisch einwandfreie Konzeption solcher Apps bereits im Designprozess f{\"u}hrt zu h{\"o}herer Akzeptanz und verbessert so die Effizienz. Diese Analyse beschreibt M{\"o}glichkeiten zur Umsetzung.},
  language  = {de}
}
@inproceedings{BeckerWolf2019,
  author    = {Becker, Willi and Wolf, Martin},
  title     = {Entwicklung eines Einf{\"u}hrungskonzepts f{\"u}r IT-Service-Management in KMU},
  series = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung / hrsg. von Martin R. Wolf, Thomas Barton, Frank Herrmann, Vera G. Meister, Christian M{\"u}ller, Christian Seel},
  booktitle = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung / hrsg. von Martin R. Wolf, Thomas Barton, Frank Herrmann, Vera G. Meister, Christian M{\"u}ller, Christian Seel},
  publisher = {mana-Buch},
  address   = {Heide},
  isbn      = {978-3-944330-62-4},
  pages     = {129 -- 137},
  year      = {2019},
  abstract  = {Obwohl es eine Vielzahl von Einf{\"u}hrungskonzepten f{\"u}r ITSM gibt, hat sich bisher keines dieser Konzepte auf breiter Linie durchgesetzt. Das gilt in erh{\"o}htem Maße f{\"u}r ITSM-Einf{\"u}hrungskonzepte f{\"u}r KMU, wohl nicht zuletzt aufgrund der Tatsache, dass der Mehrwert von ITSM f{\"u}r KMU aufgrund der geringeren Gr{\"o}ße der IT-Organisationen nur entsprechend schwieriger generiert werden kann. Mit diesem Beitrag wird ein Einf{\"u}hrungskonzept f{\"u}r ITSM in KMU systematisch hergeleitet. Daf{\"u}r wurden zun{\"a}chst die Treiber und Barrieren von ITSM untersucht, um daraus ein umfassendes Wirkmodell zu entwickeln. Da mit diesem Wirkungsmodell die Einflussfaktoren auf den Erfolg von ITSM in KMU deutlich werden, konnte auf dieser Basis ein Einf{\"u}hrungskonzept abgeleitet werden, welches insbesondere die positiven Effekte unterst{\"u}tzt bzw. verst{\"a}rkt.},
  language  = {de}
}
@inproceedings{BertschMeineckeWolfetal.2019,
  author    = {Bertsch, Timo and Meinecke, Matthias and Wolf, Martin and Schmunk, Karina},
  title     = {Smart-Living-Services nur gegen Daten? Process-Mining als M{\"o}glichkeit zur Steigerung der Akzeptanz!},
  series = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung / hrsg. von Martin R. Wolf, Thomas Barton, Frank Herrmann, Vera G. Meister, Christian M{\"u}ller, Christian Seel},
  booktitle = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung / hrsg. von Martin R. Wolf, Thomas Barton, Frank Herrmann, Vera G. Meister, Christian M{\"u}ller, Christian Seel},
  publisher = {mana-Buch},
  address   = {Heide},
  isbn      = {978-3-944330-62-4},
  pages     = {216 -- 226},
  year      = {2019},
  abstract  = {Seit Jahren etablieren sich Technologien in unserem Alltag, die mit Hilfe von smarten Komponenten neue Services und Vernetzungsm{\"o}glichkeiten schaffen. Dieses Paper beschreibt die Ergebnisse einer Studie, die die Akzeptanz von IoT-gest{\"u}tzten, smarten Services im privaten Umfeld untersucht. Dabei wird eine zentrale Datenverarbeitung mit automatisierter Erstellung smarter Services der dezentralen Datenverarbeitung mit manueller Serviceerstellung in sieben Kategorien gegen{\"u}bergestellt. Die Auswertung der Studie legt die Forschungsfrage nahe, ob das Nutzerverhalten im Kontext Smart Living nicht auch mit einem dezentralen L{\"o}sungsansatz, und somit unabh{\"a}ngig von großen Unternehmen, analysiert werden kann. Hierf{\"u}r wird im zweiten Teil des Papers die Anwendbarkeit von Process-Mining im Bereich Smart Living untersucht und prototypisch getestet.},
  language  = {de}
}
@inproceedings{KoenigKaiserWolf2019,
  author    = {K{\"o}nig, Johannes Alexander and Kaiser, Steffen and Wolf, Martin},
  title     = {Entwicklung und Evaluierung eines Regeleditors f{\"u}r die grafische Erstellung von „Smart Living Environment"-Services},
  series = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung / hrsg. von Martin R. Wolf, Thomas Barton, Frank Herrmann, Vera G. Meister, Christian M{\"u}ller, Christian Seel},
  booktitle = {Angewandte Forschung in der Wirtschaftsinformatik 2019 : Tagungsband zur 32. AKWI-Jahrestagung / hrsg. von Martin R. Wolf, Thomas Barton, Frank Herrmann, Vera G. Meister, Christian M{\"u}ller, Christian Seel},
  publisher = {mana-Buch},
  address   = {Heide},
  isbn      = {978-3-944330-62-4},
  pages     = {234 -- 243},
  year      = {2019},
  abstract  = {In diesem Paper wird die Entwicklung und Evaluation eines grafischen Regeleditors f{\"u}r das Erstellen von „Smart Living Environments"-Services vorgestellt. Daf{\"u}r werden zun{\"a}chst die Deduktion und Implementierung des grafischen Regeleditors erl{\"a}utert. Anschließend wird eine Probandenstudie vorgestellt, in welcher der Mehrwert bezogen auf die Aspekte Zeit, Fehleranf{\"a}lligkeit und Gebrauchstauglichkeit festgestellt wird.},
  language  = {de}
}
@inproceedings{MarinkovićButenweg2019,
  author    = {Marinković, Marko and Butenweg, Christoph},
  title     = {Experimental and numerical analysis of RC frames with decoupled masonry infills},
  series = {7th ECCOMAS Thematic Conference on Computational Methods in Structural Dynamics and Earthquake Engineering},
  booktitle = {7th ECCOMAS Thematic Conference on Computational Methods in Structural Dynamics and Earthquake Engineering},
  editor    = {Papadrakakis, Manolis and Fragiadakis, Michalis},
  publisher = {National Technical University of Athens},
  address   = {Athen},
  isbn      = {978-618-82844-5-6},
  issn      = {2623-3347},
  doi       = {10.7712/120119.7088.18845},
  pages     = {2464 -- 2479},
  year      = {2019},
  abstract  = {Masonry infill walls are commonly used in reinforced concrete (RC) frame structures, also in seismically active areas, although they often experience serious damage during earthquakes. One of the main reasons for their poor behaviour is the connection to the frame, which is usually constructed using mortar. This paper describes the novel solution for infill/frame connection based on application of elastomeric material between them. The system called INODIS (Innovative Decoupled Infill System) has the aim to postpone the activation of infill in in-plane direction and at the same time to provide sufficient out-of-plane support. First, experimental tests on infilled frame specimens are presented and the comparison of the results between traditionally infilled frames and infilled frames with the INODIS system are given. The results are then used for calibration and validation of numerical model, which can be further employed for investigating the influence of some material parameters on the behaviour of infilled frames with the INODIS system.},
  language  = {en}
}
@inproceedings{MichelAlderButenwegetal.2019,
  author    = {Michel, Philipp and Alder, Philipp and Butenweg, Christoph and Klinkel, Sven},
  title     = {Berechnung der Fluid-Struktur-Interaktion f{\"u}r flexibel gelagerte Fl{\"u}ssigkeitstanks},
  series = {16. D-A-CH Tagung Erdbebeningenieurwesen \& Baudynamik: 26. und 27. September 2019, Universit{\"a}t Innsbruck},
  booktitle = {16. D-A-CH Tagung Erdbebeningenieurwesen \& Baudynamik: 26. und 27. September 2019, Universit{\"a}t Innsbruck},
  isbn      = {978-3-200-06454-6},
  year      = {2019},
  language  = {de}
}
@article{BaringhausGaigall2019,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {On an asymptotic relative efficiency concept based on expected volumes of confidence regions},
  series = {Statistics - A Journal of Theoretical and Applied Statistic},
  volume    = {53},
  journal   = {Statistics - A Journal of Theoretical and Applied Statistic},
  number    = {6},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1029-4910},
  doi       = {10.1080/02331888.2019.1683560},
  pages     = {1396 -- 1436},
  year      = {2019},
  abstract  = {The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.},
  language  = {en}
}
@article{Gaigall2019,
  author    = {Gaigall, Daniel},
  title     = {On a new approach to the multi-sample goodness-of-fit problem},
  series = {Communications in Statistics - Simulation and Computation},
  volume    = {53},
  journal   = {Communications in Statistics - Simulation and Computation},
  number    = {10},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1532-4141},
  doi       = {10.1080/03610918.2019.1618472},
  pages     = {2971 -- 2989},
  year      = {2019},
  abstract  = {Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.},
  language  = {en}
}
@misc{OPUS4-10808,
  title     = {Ordnung zur {\"A}nderung der Pr{\"u}fungsordnung f{\"u}r den Bachelorstudiengang Architektur im Fachbereich Architektur an der Fachhochschule Aachen},
  address   = {Aachen},
  organization    = {FH Aachen},
  pages     = {4 Seiten},
  year      = {2019},
  abstract  = {Aufgrund des \S 2 Absatz 4 Satz 1 in Verbindung mit \S 64 des Gesetzes {\"u}ber die Hochschulen des Landes Nordrhein-Westfalen (Hochschulgesetz - HG) vom 16. September 2014 (GV. NRW. S. 547), zuletzt ge{\"a}ndert durch Artikel 3 des Gesetzes vom 17. Oktober 2017 (GV. NRW. S. 806), und der Rahmenpr{\"u}fungsordnung (RPO) f{\"u}r die Bachelor- und Masterstudieng{\"a}nge an der Fachhochschule Aachen vom 1. Februar 2018 (FH-Mitteilung Nr. 3/2018) hat der Fachbereich Architektur folgende {\"A}nderung der Pr{\"u}fungsordnung vom 5. Juli 2018 (FH-Mitteilung Nr. 104/2018) erlassen.},
  language  = {de}
}
@misc{OPUS4-10823,
  title     = {Ordnung zur {\"A}nderung der Pr{\"u}fungsordnung f{\"u}r den Masterstudiengang Architektur im Fachbereich Architektur an der Fachhochschule Aachen},
  organization    = {FH Aachen},
  pages     = {4 Seiten},
  year      = {2019},
  abstract  = {Aufgrund des \S 2 Absatz 4 Satz 1 in Verbindung mit \S 64 des Gesetzes {\"u}ber die Hochschulen des Landes Nordrhein-Westfalen (Hochschulgesetz - HG) vom 16. September 2014 (GV. NRW. S. 547), zuletzt ge{\"a}ndert durch Artikel 3 des Gesetzes vom 17. Oktober 2017 (GV. NRW. S. 806), und der Rahmenpr{\"u}fungsordnung (RPO) f{\"u}r die Bachelor- und Masterstudieng{\"a}nge an der Fachhochschule Aachen vom 1. Februar 2018 (FH-Mitteilung Nr. 3/2018) hat der Fachbereich Architektur folgende {\"A}nderung der Pr{\"u}fungsordnung vom 5. Juli 2018 (FH-Mitteilung Nr. 105/2018) erlassen.},
  language  = {de}
}
@misc{OPUS4-10825,
  title     = {Pr{\"u}fungsordnung f{\"u}r den Bachelorstudiengang Architektur im Fachbereich Architektur an der Fachhochschule Aachen},
  organization    = {FH Aachen},
  pages     = {9 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10847,
  title     = {Fremdfirmenrichtlinie der FH Aachen},
  organization    = {FH Aachen},
  pages     = {17 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10848,
  title     = {Pr{\"u}fungsordnung f{\"u}r den Masterstudiengang Architektur im Fachbereich Architektur an der Fachhochschule Aachen},
  organization    = {FH Aachen},
  pages     = {5 Seiten},
  year      = {2019},
  language  = {de}
}
@article{AchtsnichtNeuendorfFassbenderetal.2019,
  author    = {Achtsnicht, Stefan and Neuendorf, Christian and Faßbender, Tobias and N{\"o}lke, Greta and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim and Schr{\"o}per, Florian},
  title     = {Sensitive and rapid detection of cholera toxin subunit B using magnetic frequency mixing detection},
  series = {Plos One},
  volume    = {14},
  journal   = {Plos One},
  number    = {7},
  publisher = {Plos},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0219356},
  pages     = {e0219356},
  year      = {2019},
  abstract  = {Cholera is a life-threatening disease caused by the cholera toxin (CT) as produced by some Vibrio cholerae serogroups. In this research we present a method which directly detects the toxin's B subunit (CTB) in drinking water. For this purpose we performed a magnetic sandwich immunoassay inside a 3D immunofiltration column. We used two different commercially available antibodies to capture CTB and for binding to superparamagnetic beads. ELISA experiments were performed to select the antibody combination. The beads act as labels for the magnetic frequency mixing detection technique. We show that the limit of detection depends on the type of magnetic beads. A nonlinear Hill curve was fitted to the calibration measurements by means of a custom-written python software. We achieved a sensitive and rapid detection of CTB within a broad concentration range from 0.2 ng/ml to more than 700 ng/ml.},
  language  = {en}
}
@article{AchtsnichtPourshahidiOffenhaeusseretal.2019,
  author    = {Achtsnicht, Stefan and Pourshahidi, Ali Mohammad and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim},
  title     = {Multiplex detection of different magnetic beads using frequency scanning in magnetic frequency mixing technique},
  series = {Sensors},
  volume    = {19},
  journal   = {Sensors},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s19112599},
  pages     = {13 Seiten},
  year      = {2019},
  abstract  = {In modern bioanalytical methods, it is often desired to detect several targets in one sample within one measurement. Immunological methods including those that use superparamagnetic beads are an important group of techniques for these applications. The goal of this work is to investigate the feasibility of simultaneously detecting different superparamagnetic beads acting as markers using the magnetic frequency mixing technique. The frequency of the magnetic excitation field is scanned while the lower driving frequency is kept constant. Due to the particles' nonlinear magnetization, mixing frequencies are generated. To record their amplitude and phase information, a direct digitization of the pickup-coil's signal with subsequent Fast Fourier Transformation is performed. By synchronizing both magnetic beads using frequency scanning in magnetic frequency mixing technique magnetic fields, a stable phase information is gained. In this research, it is shown that the amplitude of the dominant mixing component is proportional to the amount of superparamagnetic beads inside a sample. Additionally, it is shown that the phase does not show this behaviour. Excitation frequency scans of different bead types were performed, showing different phases, without correlation to their diverse amplitudes. Two commercially available beads were selected and a determination of their amount in a mixture is performed as a demonstration for multiplex measurements.},
  language  = {en}
}
@article{AchtsnichtToedterNiehuesetal.2019,
  author    = {Achtsnicht, Stefan and T{\"o}dter, Julia and Niehues, Julia and Tel{\"o}ken, Matthias and Offenh{\"a}usser, Andreas and Krause, Hans-Joachim and Schr{\"o}per, Florian},
  title     = {3D printed modular immunofiltration columns for frequency mixing-based multiplex magnetic immunodetection},
  series = {Sensors},
  volume    = {19},
  journal   = {Sensors},
  number    = {1},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s19010148},
  pages     = {15 Seiten},
  year      = {2019},
  abstract  = {For performing point-of-care molecular diagnostics, magnetic immunoassays constitute a promising alternative to established enzyme-linked immunosorbent assays (ELISA) because they are fast, robust and sensitive. Simultaneous detection of multiple biomolecular targets from one body fluid sample is desired. The aim of this work is to show that multiplex magnetic immunodetection based on magnetic frequency mixing by means of modular immunofiltration columns prepared for different targets is feasible. By calculations of the magnetic response signal, the required spacing between the modules was determined. Immunofiltration columns were manufactured by 3D printing and antibody immobilization was performed in a batch approach. It was shown experimentally that two different target molecules in a sample solution could be individually detected in a single assaying step with magnetic measurements of the corresponding immobilization filters. The arrangement order of the filters and of a negative control did not influence the results. Thus, a simple and reliable approach to multi-target magnetic immunodetection was demonstrated.},
  language  = {en}
}