@article{KuhnertBialonskiNoenningetal.2013,
  author    = {Kuhnert, Marie-Therese and Bialonski, Stephan and Noenning, Nina and Mai, Heinke and Hinrichs, Hermann and Helmstaedter, Christoph and Lehnertz, Klaus},
  title     = {Incidental and intentional learning of verbal episodic material differentially modifies functional brain networks},
  series = {Plos one},
  volume    = {8},
  journal   = {Plos one},
  number    = {11},
  publisher = {PLOS},
  address   = {San Francisco},
  doi       = {10.1371/journal.pone.0080273},
  pages     = {e80273},
  year      = {2013},
  abstract  = {Learning- and memory-related processes are thought to result from dynamic interactions in large-scale brain networks that include lateral and mesial structures of the temporal lobes. We investigate the impact of incidental and intentional learning of verbal episodic material on functional brain networks that we derive from scalp-EEG recorded continuously from 33 subjects during a neuropsychological test schedule. Analyzing the networks' global statistical properties we observe that intentional but not incidental learning leads to a significantly increased clustering coefficient, and the average shortest path length remains unaffected. Moreover, network modifications correlate with subsequent recall performance: the more pronounced the modifications of the clustering coefficient, the higher the recall performance. Our findings provide novel insights into the relationship between topological aspects of functional brain networks and higher cognitive functions.},
  language  = {en}
}
@article{BialonskiLehnertz2013,
  author    = {Bialonski, Stephan and Lehnertz, Klaus},
  title     = {Assortative mixing in functional brain networks during epileptic seizures},
  series = {Chaos: An Interdisciplinary Journal of Nonlinear Science},
  volume    = {23},
  journal   = {Chaos: An Interdisciplinary Journal of Nonlinear Science},
  number    = {3},
  doi       = {10.1063/1.4821915},
  pages     = {033139},
  year      = {2013},
  language  = {en}
}
@article{SchindlerBialonskiHorstmannetal.2008,
  author    = {Schindler, Kaspar A. and Bialonski, Stephan and Horstmann, Marie-Therese and Elger, Christian E. and Lehnertz, Klaus},
  title     = {Evolving functional network properties and synchronizability during human epileptic seizures},
  series = {Chaos: An Interdisciplinary Journal of Nonlinear Science},
  volume    = {18},
  journal   = {Chaos: An Interdisciplinary Journal of Nonlinear Science},
  number    = {3},
  issn      = {1089-7682},
  doi       = {10.1063/1.2966112},
  pages     = {033119},
  year      = {2008},
  language  = {en}
}
@article{BialonskiAllefeldWellmeretal.2008,
  author    = {Bialonski, Stephan and Allefeld, C. and Wellmer, J. and Elger, C. and Lehnertz, K.},
  title     = {An approach to identify synchronization clusters within the epileptic network},
  series = {Klinische Neurophysiologie},
  volume    = {39},
  journal   = {Klinische Neurophysiologie},
  number    = {1},
  doi       = {10.1055/s-2008-1072881},
  pages     = {A79},
  year      = {2008},
  language  = {en}
}
@article{BialonskiSchindlerElgeretal.2008,
  author    = {Bialonski, Stephan and Schindler, K. and Elger, C. E. and Lehnertz, Klaus},
  title     = {Lateralized characteristics of the evolution of EEG correlation during focal onset seizures: a mechanism to prevent secondary generalization?},
  series = {Epilepsia},
  volume    = {49},
  journal   = {Epilepsia},
  issn      = {0013-9580},
  pages     = {11 -- 11},
  year      = {2008},
  abstract  = {Rationale: Previous studies [Topolnik et al., Cereb Cortex 2003; 13: 883; Schindler et al., Brain 2007; 130: 65] indicate that the termination of focal onset seizures may be causally related to an increase of global neuronal correlation during the second half of the seizures. This increase was observed to occur earlier in complex partial seizures than in secondarily generalized seizures. We here address the question whether such an increase of neuronal correlation prior to seizure end is indeed a global phenomenon, involving both hemispheres or whether there are side-specific differences. Methods: We analyzed 20 focal onset seizures (10 complex partial, 10 secondarily generalized seizures) recorded in 13 patients who underwent presurgical evaluation of focal epilepsies of different origin. EEG was recorded intracranially from bilaterally implanted subdural strip and intrahippocampal depth electrodes. Utilizing a moving window approach, we investigated the evolution of the maximum cross correlation for all channel combinations during seizures. For each moving window the mean value of the maximum cross correlation (MCC) between all electrode contacts was computed separately for each hemisphere. After normalization of seizure durations, MCC values of the ipsi- and contralateral hemisphere for all seizures were determined. Results: We observed that the MCC of the contralateral hemisphere in complex partial seizures increased during the first half of the seizure, whereas, for the same time interval, the MCC of the ipsilateral hemisphere even declined below the level of the pre-seizure period. In contrast, no significant differences between both hemispheres could be observed for secondarily generalized seizures where both hemispheres showed a simultaneous increase of MCC during the second half of the seizures. The level of MCC for the contralateral hemisphere was higher for complex partial seizures than for secondarily generalized seizures during the first half of the seizure. Conclusions: Our findings indicate that there are indeed lateralized differences in the evolution of global neuronal correlation during complex partial and secondarily generalized seizures. The observed contralateral increase of neuronal correlation during complex partial seizures might indicate an emerging self-organizing mechanism for preventing the spread of seizure activity.},
  language  = {en}
}
@article{AllefeldBialonski2007,
  author    = {Allefeld, Carsten and Bialonski, Stephan},
  title     = {Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains},
  series = {Physical Review E},
  volume    = {76},
  journal   = {Physical Review E},
  number    = {6},
  issn      = {2470-0053},
  doi       = {10.1103/PhysRevE.76.066207},
  pages     = {066207},
  year      = {2007},
  language  = {en}
}
@article{LehnertzMormannOsterhageetal.2007,
  author    = {Lehnertz, Klaus and Mormann, Florian and Osterhage, Hannes and Andy, M{\"u}ller and Prusseit, Jens and Chernihovskyi, Anton and Staniek, Matth{\"a}us and Krug, Dieter and Bialonski, Stephan and Elger, Christian E.},
  title     = {State-of-the-art of seizure prediction},
  series = {Journal of Clinical Neurophysiology},
  volume    = {24},
  journal   = {Journal of Clinical Neurophysiology},
  number    = {2},
  issn      = {1537-1603},
  doi       = {10.1097/WNP.0b013e3180336f16},
  pages     = {147 -- 153},
  year      = {2007},
  language  = {en}
}
@article{BialonskiLehnertz2006,
  author    = {Bialonski, Stephan and Lehnertz, Klaus},
  title     = {Identifying phase synchronization clusters in spatially extended dynamical systems},
  series = {Physical Review E},
  volume    = {74},
  journal   = {Physical Review E},
  number    = {5},
  issn      = {2470-0053},
  doi       = {10.1103/PhysRevE.74.051909},
  pages     = {051909},
  year      = {2006},
  language  = {en}
}
@article{BialonskiWellmerElgeretal.2006,
  author    = {Bialonski, Stephan and Wellmer, J{\"o}rg and Elger, Christian E. and Lehnertz, Klaus},
  title     = {Interictal focus localization in neocortical lesional epilepsies with synchronization cluster analysis},
  series = {Epilepsia},
  volume    = {47},
  journal   = {Epilepsia},
  issn      = {0013-9580},
  pages     = {36},
  year      = {2006},
  language  = {en}
}
@article{RichterBraunsteinWinnardetal.2017,
  author    = {Richter, Charlotte and Braunstein, Bjoern and Winnard, Andrew and Nasser, Mona and Weber, T.},
  title     = {Human Biomechanical and Cardiopulmonary Responses to Partial Gravity - A Systematic Review},
  series = {Frontiers in physiology},
  journal   = {Frontiers in physiology},
  number    = {8, article 583},
  doi       = {10.3389/fphys.2017.00583},
  pages     = {22 Seiten},
  year      = {2017},
  language  = {en}
}
@article{JildehWagnerSchoening2021,
  author    = {Jildeh, Zaid B. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef},
  title     = {Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000732},
  pages     = {27 Seiten},
  year      = {2021},
  abstract  = {The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.},
  language  = {en}
}
@article{MolinnusDrinicIkenetal.2021,
  author    = {Molinnus, Denise and Drinic, Aleksander and Iken, Heiko and Kr{\"o}ger, Nadja and Zinser, Max and Smeets, Ralf and K{\"o}pf, Marius and Kopp, Alexander and Sch{\"o}ning, Michael Josef},
  title     = {Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk},
  series = {Biosensors and Bioelectronics},
  volume    = {183},
  journal   = {Biosensors and Bioelectronics},
  number    = {Art. 113204},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0956-5663},
  doi       = {10.1016/j.bios.2021.113204},
  year      = {2021},
  language  = {en}
}
@article{NguyenXuanRabczukNguyenThoietal.2011,
  author    = {Nguyen-Xuan, H. and Rabczuk, T. and Nguyen-Thoi, T. and Tran, Thanh Ngoc and Nguyen-Thanh, N.},
  title     = {Computation of limit and shakedown loads using a node-based smoothed finite element method},
  series = {International Journal for Numerical Methods in Engineering},
  volume    = {90},
  journal   = {International Journal for Numerical Methods in Engineering},
  number    = {3},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1097-0207},
  doi       = {10.1002/nme.3317},
  pages     = {287 -- 310},
  year      = {2011},
  abstract  = {This paper presents a novel numerical procedure for computing limit and shakedown loads of structures using a node-based smoothed FEM in combination with a primal-dual algorithm. An associated primal-dual form based on the von Mises yield criterion is adopted. The primal-dual algorithm together with a Newton-like iteration are then used to solve this associated primal-dual form to determine simultaneously both approximate upper and quasi-lower bounds of the plastic collapse limit and the shakedown limit. The present formulation uses only linear approximations and its implementation into finite element programs is quite simple. Several numerical examples are given to show the reliability, accuracy, and generality of the present formulation compared with other available methods.},
  language  = {en}
}
@article{YoshinobuSchoening2021,
  author    = {Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {Light-addressable potentiometric sensors (LAPS) for cell monitoring and biosensing},
  series = {Current Opinion in Electrochemistry},
  journal   = {Current Opinion in Electrochemistry},
  number    = {In Press, Journal Pre-proof},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2451-9103},
  doi       = {10.1016/j.coelec.2021.100727},
  year      = {2021},
  language  = {en}
}
@article{JablonskiMuenstermannNorketal.2021,
  author    = {Jablonski, Melanie and M{\"u}nstermann, Felix and Nork, Jasmina and Molinnus, Denise and Muschallik, Lukas and Bongaerts, Johannes and Wagner, Torsten and Keusgen, Michael and Siegert, Petra and Sch{\"o}ning, Michael Josef},
  title     = {Capacitive field-effect biosensor applied for the detection of acetoin in alcoholic beverages and fermentation broths},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000765},
  pages     = {7 Seiten},
  year      = {2021},
  abstract  = {An acetoin biosensor based on a capacitive electrolyte-insulator-semiconductor (EIS) structure modified with the enzyme acetoin reductase, also known as butane-2,3-diol dehydrogenase (Bacillus clausii DSM 8716ᵀ), is applied for acetoin detection in beer, red wine, and fermentation broth samples for the first time. The EIS sensor consists of an Al/p-Si/SiO₂/Ta₂O₅ layer structure with immobilized acetoin reductase on top of the Ta₂O₅ transducer layer by means of crosslinking via glutaraldehyde. The unmodified and enzyme-modified sensors are electrochemically characterized by means of leakage current, capacitance-voltage, and constant capacitance methods, respectively.},
  language  = {en}
}
@article{WertIkenSchoeningetal.2021,
  author    = {Wert, Stefan and Iken, Heiko and Sch{\"o}ning, Michael Josef and Matysik, Frank-Michael},
  title     = {Development of a temperature-pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy},
  series = {Electroanalysis},
  journal   = {Electroanalysis},
  number    = {Early View},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-4109},
  doi       = {10.1002/elan.202100089},
  year      = {2021},
  abstract  = {Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating.},
  language  = {en}
}
@article{WaldvogelRitzmannFreyleretal.2021,
  author    = {Waldvogel, Janice and Ritzmann, Ramona and Freyler, Kathrin and Helm, Michael and Monti, Elena and Albracht, Kirsten and St{\"a}udle, Benjamin and Gollhofer, Albert and Narici, Marco},
  title     = {The Anticipation of Gravity in Human Ballistic Movement},
  series = {Frontiers in Physiology},
  journal   = {Frontiers in Physiology},
  publisher = {Frontiers},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2021.614060},
  year      = {2021},
  abstract  = {Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation.},
  language  = {en}
}
@article{HugenrothNeidlinEngelmannetal.2021,
  author    = {Hugenroth, Kristin and Neidlin, Michael and Engelmann, Ulrich M. and Kaufmann, Tim A. S. and Steinseifer, Ulrich and Heilmann, Torsten},
  title     = {Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk-Reduced Placement: an In Silico Proof-of-Concept},
  series = {Artificial Organs},
  journal   = {Artificial Organs},
  number    = {Accepted Article},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1525-1594},
  doi       = {10.1111/aor.13964},
  year      = {2021},
  language  = {en}
}
@article{JablonskiPoghossianSeverinetal.2021,
  author    = {Jablonski, Melanie and Poghossian, Arshak and Severin, Robin and Keusgen, Michael and Wege, Christian and Sch{\"o}ning, Michael Josef},
  title     = {Capacitive Field-Effect Biosensor Studying Adsorption of Tobacco Mosaic Virus Particles},
  series = {Micromachines},
  volume    = {12},
  journal   = {Micromachines},
  number    = {1},
  publisher = {MDPI},
  address   = {Basel},
  doi       = {10.3390/mi12010057},
  pages     = {Artikel 57},
  year      = {2021},
  abstract  = {Plant virus-like particles, and in particular, tobacco mosaic virus (TMV) particles, are increasingly being used in nano- and biotechnology as well as for biochemical sensing purposes as nanoscaffolds for the high-density immobilization of receptor molecules. The sensitive parameters of TMV-assisted biosensors depend, among others, on the density of adsorbed TMV particles on the sensor surface, which is affected by both the adsorption conditions and surface properties of the sensor. In this work, Ta₂O₅-gate field-effect capacitive sensors have been applied for the label-free electrical detection of TMV adsorption. The impact of the TMV concentration on both the sensor signal and the density of TMV particles adsorbed onto the Ta₂O₅-gate surface has been studied systematically by means of field-effect and scanning electron microscopy methods. In addition, the surface density of TMV particles loaded under different incubation times has been investigated. Finally, the field-effect sensor also demonstrates the label-free detection of penicillinase immobilization as model bioreceptor on TMV particles.},
  language  = {en}
}
@article{PogorelovaRogachevDigeletal.2020,
  author    = {Pogorelova, Natalia and Rogachev, Evgeniy and Digel, Ilya and Chernigova, Svetlana and Nardin, Dmitry},
  title     = {Bacterial Cellulose Nanocomposites: Morphology and Mechanical Properties},
  series = {Materials},
  volume    = {13},
  journal   = {Materials},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  isbn      = {1996-1944},
  doi       = {10.3390/ma13122849},
  pages     = {1 -- 16},
  year      = {2020},
  abstract  = {Bacterial cellulose (BC) is a promising material for biomedical applications due to its unique properties such as high mechanical strength and biocompatibility. This article describes the microbiological synthesis, modification, and characterization of the obtained BC-nanocomposites originating from symbiotic consortium Medusomyces gisevii. Two BC-modifications have been obtained: BC-Ag and BC-calcium phosphate (BC-Ca3(PO4)2). Structure and physicochemical properties of the BC and its modifications were investigated by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM), and infrared Fourier spectroscopy as well as by measurements of mechanical and water holding/absorbing capacities. Topographic analysis of the surface revealed multicomponent thick fibrils (150-160 nm in diameter and about 15 µm in length) constituted by 50-60 nm nanofibrils weaved into a left-hand helix. Distinctive features of Ca-phosphate-modified BC samples were (a) the presence of 500-700 nm entanglements and (b) inclusions of Ca3(PO4)2 crystals. The samples impregnated with Ag nanoparticles exhibited numerous roundish inclusions, about 110 nm in diameter. The boundaries between the organic and inorganic phases were very distinct in both cases. The Ag-modified samples also showed a prominent waving pattern in the packing of nanofibrils. The obtained BC gel films possessed water-holding capacity of about 62.35 g/g. However, the dried (to a constant mass) BC-films later exhibited a low water absorption capacity (3.82 g/g). It was found that decellularized BC samples had 2.4 times larger Young's modulus and 2.2 times greater tensile strength as compared to dehydrated native BC films. We presume that this was caused by molecular compaction of the BC structure.},
  language  = {en}
}
@article{MoratFaudeHanssenetal.2020,
  author    = {Morat, Mareike and Faude, Oliver and Hanssen, Henner and Ludyga, Sebastian and Zacher, Jonas and Eibl, Angi and Albracht, Kirsten and Donath, Lars},
  title     = {Agility Training to Integratively Promote Neuromuscular, Cognitive, Cardiovascular and Psychosocial Function in Healthy Older Adults: A Study Protocol of a One-Year Randomized-Controlled Trial},
  series = {International Journal of Environmental Research and Public Health},
  volume    = {17},
  journal   = {International Journal of Environmental Research and Public Health},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1660-4601},
  doi       = {10.3390/ijerph17061853},
  pages     = {1 -- 14},
  year      = {2020},
  abstract  = {Exercise training effectively mitigates aging-induced health and fitness impairments. Traditional training recommendations for the elderly focus separately on relevant physiological fitness domains, such as balance, flexibility, strength and endurance. Thus, a more holistic and functional training framework is needed. The proposed agility training concept integratively tackles spatial orientation, stop and go, balance and strength. The presented protocol aims at introducing a two-armed, one-year randomized controlled trial, evaluating the effects of this concept on neuromuscular, cardiovascular, cognitive and psychosocial health outcomes in healthy older adults. Eighty-five participants were enrolled in this ongoing trial. Seventy-nine participants completed baseline testing and were block-randomized to the agility training group or the inactive control group. All participants undergo pre- and post-testing with interim assessment after six months. The intervention group currently receives supervised, group-based agility training twice a week over one year, with progressively demanding perceptual, cognitive and physical exercises. Knee extension strength, reactive balance, dual task gait speed and the Agility Challenge for the Elderly (ACE) serve as primary endpoints and neuromuscular, cognitive, cardiovascular, and psychosocial meassures serve as surrogate secondary outcomes. Our protocol promotes a comprehensive exercise training concept for older adults, that might facilitate stakeholders in health and exercise to stimulate relevant health outcomes without relying on excessively time-consuming physical activity recommendations.},
  language  = {en}
}
@article{GivanoudiCornelisRasschaertetal.2021,
  author    = {Givanoudi, Stella and Cornelis, Peter and Rasschaert, Geertrui and Wackers, Gideon and Iken, Heiko and Rolka, David and Yongabi, Derick and Robbens, Johan and Sch{\"o}ning, Michael Josef and Heyndrickx, Marc and Wagner, Patrick},
  title     = {Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source},
  series = {Sensors and Actuators B: Chemical},
  journal   = {Sensors and Actuators B: Chemical},
  number    = {In Press, Journal Pre-proof},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2021.129484},
  pages     = {Article 129484},
  year      = {2021},
  language  = {en}
}
@article{MalinowskiFournierHorbachetal.2022,
  author    = {Malinowski, Daniel and Fournier, Yvan and Horbach, Andreas and Frick, Michael and Magliani, Mirko and Kalverkamp, Sebastian and Hildinger, Martin and Spillner, Jan and Behbahani, Mehdi and Hima, Flutura},
  title     = {Computational fluid dynamics analysis of endoluminal aortic perfusion},
  series = {Perfusion},
  volume    = {0},
  journal   = {Perfusion},
  number    = {0},
  publisher = {Sage},
  address   = {London},
  issn      = {1477-111X},
  doi       = {10.1177/02676591221099809},
  pages     = {1 -- 8},
  year      = {2022},
  abstract  = {Introduction: In peripheral percutaneous (VA) extracorporeal membrane oxygenation (ECMO) procedures the femoral arteries perfusion route has inherent disadvantages regarding poor upper body perfusion due to watershed. With the advent of new long flexible cannulas an advancement of the tip up to the ascending aorta has become feasible. To investigate the impact of such long endoluminal cannulas on upper body perfusion, a Computational Fluid Dynamics (CFD) study was performed considering different support levels and three cannula positions. Methods: An idealized literature-based- and a real patient proximal aortic geometry including an endoluminal cannula were constructed. The blood flow was considered continuous. Oxygen saturation was set to 80\% for the blood coming from the heart and to 100\% for the blood leaving the cannula. 50\% and 90\% venoarterial support levels from the total blood flow rate of 6 l/min were investigated for three different positions of the cannula in the aortic arch. Results: For both geometries, the placement of the cannula in the ascending aorta led to a superior oxygenation of all aortic blood vessels except for the left coronary artery. Cannula placements at the aortic arch and descending aorta could support supra-aortic arteries, but not the coronary arteries. All positions were able to support all branches with saturated blood at 90\% flow volume. Conclusions: In accordance with clinical observations CFD analysis reveals, that retrograde advancement of a long endoluminal cannula can considerably improve the oxygenation of the upper body and lead to oxygen saturation distributions similar to those of a central cannulation.},
  language  = {en}
}
@article{LenzKahmannBehbahanietal.2022,
  author    = {Lenz, Maximilian and Kahmann, Stephanie Lucina and Behbahani, Mehdi and Pennig, Lenhard and Hackl, Michael and Leschinger, Tim and M{\"u}ller, Lars Peter and Wegmann, Kilian},
  title     = {Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation},
  series = {Archives of Orthopaedic and Trauma Surgery},
  journal   = {Archives of Orthopaedic and Trauma Surgery},
  publisher = {Springer},
  address   = {Berlin, Heidelberg},
  issn      = {1434-3916},
  doi       = {10.1007/s00402-022-04471-9},
  year      = {2022},
  abstract  = {Introduction In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration. Materials and methods Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer's classification was used to analyse the fractures. Results In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities. Conclusion A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education.},
  language  = {en}
}
@article{ChloeMalyaranCraveiroetal.2022,
  author    = {Chlo{\´e}, Radermacher and Malyaran, Hanna and Craveiro, Rogerio Bastos and Peglow, Sarah and Behbahani, Mehdi and Pufe, Thomas and Wolf, Michael and Neuss, Sabine},
  title     = {Mechanical loading on cementoblasts: a mini review},
  series = {Osteologie},
  volume    = {31},
  journal   = {Osteologie},
  number    = {2},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {1019-1291},
  doi       = {10.1055/a-1826-0777},
  pages     = {111 -- 118},
  year      = {2022},
  abstract  = {Orthodontic treatments are concomitant with mechanical forces and thereby cause teeth movements. The applied forces are transmitted to the tooth root and the periodontal ligaments which is compressed on one side and tensed up on the other side. Indeed, strong forces can lead to tooth root resorption and the crown-to-tooth ratio is reduced with the potential for significant clinical impact. The cementum, which covers the tooth root, is a thin mineralized tissue of the periodontium that connects the periodontal ligament with the tooth and is build up by cementoblasts. The impact of tension and compression on these cells is investigated in several in vivo and in vitro studies demonstrating differences in protein expression and signaling pathways. In summary, osteogenic marker changes indicate that cyclic tensile forces support whereas static tension inhibits cementogenesis. Furthermore, cementogenesis experiences the same protein expression changes in static conditions as static tension, but cyclic compression leads to the exact opposite of cyclic tension. Consistent with marker expression changes, the singaling pathways of Wnt/ß-catenin and RANKL/OPG show that tissue compression leads to cementum degradation and tension forces to cementogenesis. However, the cementum, and in particular its cementoblasts, remain a research area which should be explored in more detail to understand the underlying mechanism of bone resorption and remodeling after orthodontic treatments.},
  language  = {en}
}
@article{AngermannGuenthnerHanssenetal.2022,
  author    = {Angermann, Susanne and G{\"u}nthner, Roman and Hanssen, Henner and Lorenz, Georg and Braunisch, Matthias C. and Steubl, Dominik and Matschkal, Julia and Kemmner, Stephan and Hausinger, Renate and Block, Zenonas and Haller, Bernhard and Heemann, Uwe and Kotliar, Konstantin and Grimmer, Timo and Schmaderer, Christoph},
  title     = {Cognitive impairment and microvascular function in end-stage renal disease},
  series = {International Journal of Methods in Psychiatric Research (MPR)},
  volume    = {31},
  journal   = {International Journal of Methods in Psychiatric Research (MPR)},
  number    = {2},
  publisher = {Wiley},
  issn      = {1049-8931 (Print)},
  doi       = {10.1002/mpr.1909},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.},
  language  = {en}
}
@article{BaringhausGaigall2015,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {On an independence test approach to the goodness-of-fit problem},
  series = {Journal of Multivariate Analysis},
  volume    = {2015},
  journal   = {Journal of Multivariate Analysis},
  number    = {140},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0047-259X},
  doi       = {10.1016/j.jmva.2015.05.013},
  pages     = {193 -- 208},
  year      = {2015},
  abstract  = {Let X₁,…,Xₙ be independent and identically distributed random variables with distribution F. Assuming that there are measurable functions f:R²→R and g:R²→R characterizing a family F of distributions on the Borel sets of R in the way that the random variables f(X₁,X₂),g(X₁,X₂) are independent, if and only if F∈F, we propose to treat the testing problem H:F∈F,K:F∉F by applying a consistent nonparametric independence test to the bivariate sample variables (f(Xᵢ,Xⱼ),g(Xᵢ,Xⱼ)),1⩽i,j⩽n,i≠j. A parametric bootstrap procedure needed to get critical values is shown to work. The consistency of the test is discussed. The power performance of the procedure is compared with that of the classical tests of Kolmogorov-Smirnov and Cram{\´e}r-von Mises in the special cases where F is the family of gamma distributions or the family of inverse Gaussian distributions.},
  language  = {en}
}
@article{RuebbelkeVoegeleGrajewskietal.2023,
  author    = {R{\"u}bbelke, Dirk and V{\"o}gele, Stefan and Grajewski, Matthias and Zobel, Luzy},
  title     = {Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production},
  series = {Data in Brief},
  volume    = {47},
  journal   = {Data in Brief},
  number    = {Article 108907},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2352-3409},
  doi       = {10.1016/j.dib.2023.108907},
  pages     = {1 -- 5},
  year      = {2023},
  abstract  = {Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (R{\"u}bbelke, 2022).},
  language  = {en}
}
@article{AkimbekovDigelTastambeketal.2022,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Tastambek, Kuanysh T. and Marat, Adel K. and Turaliyeva, Moldir A. and Kaiyrmanova, Gulzhan K.},
  title     = {Biotechnology of Microorganisms from Coal Environments: From Environmental Remediation to Energy Production},
  series = {Biology},
  volume    = {11},
  journal   = {Biology},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-7737},
  doi       = {10.3390/biology11091306},
  pages     = {47 Seiten},
  year      = {2022},
  abstract  = {It was generally believed that coal sources are not favorable as live-in habitats for microorganisms due to their recalcitrant chemical nature and negligible decomposition. However, accumulating evidence has revealed the presence of diverse microbial groups in coal environments and their significant metabolic role in coal biogeochemical dynamics and ecosystem functioning. The high oxygen content, organic fractions, and lignin-like structures of lower-rank coals may provide effective means for microbial attack, still representing a greatly unexplored frontier in microbiology. Coal degradation/conversion technology by native bacterial and fungal species has great potential in agricultural development, chemical industry production, and environmental rehabilitation. Furthermore, native microalgal species can offer a sustainable energy source and an excellent bioremediation strategy applicable to coal spill/seam waters. Additionally, the measures of the fate of the microbial community would serve as an indicator of restoration progress on post-coal-mining sites. This review puts forward a comprehensive vision of coal biodegradation and bioprocessing by microorganisms native to coal environments for determining their biotechnological potential and possible applications.},
  language  = {en}
}
@article{DitzhausGaigall2022,
  author    = {Ditzhaus, Marc and Gaigall, Daniel},
  title     = {Testing marginal homogeneity in Hilbert spaces with applications to stock market returns},
  series = {Test},
  volume    = {2022},
  journal   = {Test},
  number    = {31},
  publisher = {Springer},
  issn      = {1863-8260},
  doi       = {10.1007/s11749-022-00802-5},
  pages     = {749 -- 770},
  year      = {2022},
  abstract  = {This paper considers a paired data framework and discusses the question of marginal homogeneity of bivariate high-dimensional or functional data. The related testing problem can be endowed into a more general setting for paired random variables taking values in a general Hilbert space. To address this problem, a Cram{\´e}r-von-Mises type test statistic is applied and a bootstrap procedure is suggested to obtain critical values and finally a consistent test. The desired properties of a bootstrap test can be derived that are asymptotic exactness under the null hypothesis and consistency under alternatives. Simulations show the quality of the test in the finite sample case. A possible application is the comparison of two possibly dependent stock market returns based on functional data. The approach is demonstrated based on historical data for different stock market indices.},
  language  = {en}
}
@article{GaigallGerstenbergTrinh2022,
  author    = {Gaigall, Daniel and Gerstenberg, Julian and Trinh, Thi Thu Ha},
  title     = {Empirical process of concomitants for partly categorial data and applications in statistics},
  series = {Bernoulli},
  volume    = {28},
  journal   = {Bernoulli},
  number    = {2},
  publisher = {International Statistical Institute},
  address   = {Den Haag, NL},
  issn      = {1573-9759},
  doi       = {10.3150/21-BEJ1367},
  pages     = {803 -- 829},
  year      = {2022},
  abstract  = {On the basis of independent and identically distributed bivariate random vectors, where the components are categorial and continuous variables, respectively, the related concomitants, also called induced order statistic, are considered. The main theoretical result is a functional central limit theorem for the empirical process of the concomitants in a triangular array setting. A natural application is hypothesis testing. An independence test and a two-sample test are investigated in detail. The fairly general setting enables limit results under local alternatives and bootstrap samples. For the comparison with existing tests from the literature simulation studies are conducted. The empirical results obtained confirm the theoretical findings.},
  language  = {en}
}
@article{Gaigall2021,
  author    = {Gaigall, Daniel},
  title     = {Test for Changes in the Modeled Solvency Capital Requirement of an Internal Risk Model},
  series = {ASTIN Bulletin},
  volume    = {51},
  journal   = {ASTIN Bulletin},
  number    = {3},
  publisher = {Cambridge Univ. Press},
  address   = {Cambridge},
  issn      = {1783-1350},
  doi       = {10.1017/asb.2021.20},
  pages     = {813 -- 837},
  year      = {2021},
  abstract  = {In the context of the Solvency II directive, the operation of an internal risk model is a possible way for risk assessment and for the determination of the solvency capital requirement of an insurance company in the European Union. A Monte Carlo procedure is customary to generate a model output. To be compliant with the directive, validation of the internal risk model is conducted on the basis of the model output. For this purpose, we suggest a new test for checking whether there is a significant change in the modeled solvency capital requirement. Asymptotic properties of the test statistic are investigated and a bootstrap approximation is justified. A simulation study investigates the performance of the test in the finite sample case and confirms the theoretical results. The internal risk model and the application of the test is illustrated in a simplified example. The method has more general usage for inference of a broad class of law-invariant and coherent risk measures on the basis of a paired sample.},
  language  = {en}
}
@article{Gaigall2020,
  author    = {Gaigall, Daniel},
  title     = {Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic on partly not identically distributed data},
  series = {Communications in Statistics - Theory and Methods},
  volume    = {51},
  journal   = {Communications in Statistics - Theory and Methods},
  number    = {12},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1532-415X},
  doi       = {10.1080/03610926.2020.1805767},
  pages     = {4006 -- 4028},
  year      = {2020},
  abstract  = {The established Hoeffding-Blum-Kiefer-Rosenblatt independence test statistic is investigated for partly not identically distributed data. Surprisingly, it turns out that the statistic has the well-known distribution-free limiting null distribution of the classical criterion under standard regularity conditions. An application is testing goodness-of-fit for the regression function in a non parametric random effects meta-regression model, where the consistency is obtained as well. Simulations investigate size and power of the approach for small and moderate sample sizes. A real data example based on clinical trials illustrates how the test can be used in applications.},
  language  = {en}
}
@article{SchoeningBronderWuetal.2017,
  author    = {Sch{\"o}ning, Michael Josef and Bronder, Thomas and Wu, Chunsheng and Scheja, Sabrina and Jessing, Max and Metzger-Boddien, Christoph and Keusgen, Michael and Poghossian, Arshak},
  title     = {Label-Free DNA Detection with Capacitive Field-Effect Devices—Challenges and Opportunities},
  series = {Proceedings},
  volume    = {1},
  journal   = {Proceedings},
  number    = {8},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2504-3900},
  doi       = {10.3390/proceedings1080719},
  pages     = {Artikel 719},
  year      = {2017},
  abstract  = {Field-effect EIS (electrolyte-insulator-semiconductor) sensors modified with a positively charged weak polyelectrolyte layer have been applied for the electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge. The EIS sensors are able to detect the existence of target DNA amplicons in PCR (polymerase chain reaction) samples and thus, can be used as tool for a quick verification of DNA amplification and the successful PCR process. Due to their miniaturized setup, compatibility with advanced micro- and nanotechnologies, and ability to detect biomolecules by their intrinsic molecular charge, those sensors can serve as possible platform for the development of label-free DNA chips. Possible application fields as well as challenges and limitations will be discussed.},
  language  = {en}
}
@article{Gaigall2020,
  author    = {Gaigall, Daniel},
  title     = {Testing marginal homogeneity of a continuous bivariate distribution with possibly incomplete paired data},
  series = {Metrika},
  volume    = {2020},
  journal   = {Metrika},
  number    = {83},
  publisher = {Springer},
  issn      = {1435-926X},
  doi       = {10.1007/s00184-019-00742-5},
  pages     = {437 -- 465},
  year      = {2020},
  abstract  = {We discuss the testing problem of homogeneity of the marginal distributions of a continuous bivariate distribution based on a paired sample with possibly missing components (missing completely at random). Applying the well-known two-sample Cr{\´a}mer-von-Mises distance to the remaining data, we determine the limiting null distribution of our test statistic in this situation. It is seen that a new resampling approach is appropriate for the approximation of the unknown null distribution. We prove that the resulting test asymptotically reaches the significance level and is consistent. Properties of the test under local alternatives are pointed out as well. Simulations investigate the quality of the approximation and the power of the new approach in the finite sample case. As an illustration we apply the test to real data sets.},
  language  = {en}
}
@article{Gaigall2020,
  author    = {Gaigall, Daniel},
  title     = {Rothman-Woodroofe symmetry test statistic revisited},
  series = {Computational Statistics \& Data Analysis},
  volume    = {2020},
  journal   = {Computational Statistics \& Data Analysis},
  number    = {142},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0167-9473},
  doi       = {10.1016/j.csda.2019.106837},
  pages     = {Artikel 106837},
  year      = {2020},
  abstract  = {The Rothman-Woodroofe symmetry test statistic is revisited on the basis of independent but not necessarily identically distributed random variables. The distribution-freeness if the underlying distributions are all symmetric and continuous is obtained. The results are applied for testing symmetry in a meta-analysis random effects model. The consistency of the procedure is discussed in this situation as well. A comparison with an alternative proposal from the literature is conducted via simulations. Real data are analyzed to demonstrate how the new approach works in practice.},
  language  = {en}
}
@article{BaringhausGaigall2019,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {On an asymptotic relative efficiency concept based on expected volumes of confidence regions},
  series = {Statistics - A Journal of Theoretical and Applied Statistic},
  volume    = {53},
  journal   = {Statistics - A Journal of Theoretical and Applied Statistic},
  number    = {6},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1029-4910},
  doi       = {10.1080/02331888.2019.1683560},
  pages     = {1396 -- 1436},
  year      = {2019},
  abstract  = {The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.},
  language  = {en}
}
@article{Gaigall2019,
  author    = {Gaigall, Daniel},
  title     = {On a new approach to the multi-sample goodness-of-fit problem},
  series = {Communications in Statistics - Simulation and Computation},
  volume    = {53},
  journal   = {Communications in Statistics - Simulation and Computation},
  number    = {10},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1532-4141},
  doi       = {10.1080/03610918.2019.1618472},
  pages     = {2971 -- 2989},
  year      = {2019},
  abstract  = {Suppose we have k samples X₁,₁,…,X₁,ₙ₁,…,Xₖ,₁,…,Xₖ,ₙₖ with different sample sizes ₙ₁,…,ₙₖ and unknown underlying distribution functions F₁,…,Fₖ as observations plus k families of distribution functions {G₁(⋅,ϑ);ϑ∈Θ},…,{Gₖ(⋅,ϑ);ϑ∈Θ}, each indexed by elements ϑ from the same parameter set Θ, we consider the new goodness-of-fit problem whether or not (F₁,…,Fₖ) belongs to the parametric family {(G₁(⋅,ϑ),…,Gₖ(⋅,ϑ));ϑ∈Θ}. New test statistics are presented and a parametric bootstrap procedure for the approximation of the unknown null distributions is discussed. Under regularity assumptions, it is proved that the approximation works asymptotically, and the limiting distributions of the test statistics in the null hypothesis case are determined. Simulation studies investigate the quality of the new approach for small and moderate sample sizes. Applications to real-data sets illustrate how the idea can be used for verifying model assumptions.},
  language  = {en}
}
@article{DitzhausGaigall2018,
  author    = {Ditzhaus, Marc and Gaigall, Daniel},
  title     = {A consistent goodness-of-fit test for huge dimensional and functional data},
  series = {Journal of Nonparametric Statistics},
  volume    = {30},
  journal   = {Journal of Nonparametric Statistics},
  number    = {4},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1029-0311},
  doi       = {10.1080/10485252.2018.1486402},
  pages     = {834 -- 859},
  year      = {2018},
  abstract  = {A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cram{\´e}r-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals.},
  language  = {en}
}
@article{BaringhausGaigallThiele2018,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel and Thiele, Jan Philipp},
  title     = {Statistical inference for L²-distances to uniformity},
  series = {Computational Statistics},
  volume    = {2018},
  journal   = {Computational Statistics},
  number    = {33},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1613-9658},
  doi       = {10.1007/s00180-018-0820-0},
  pages     = {1863 -- 1896},
  year      = {2018},
  abstract  = {The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study.},
  language  = {en}
}
@article{BaringhausGaigall2017,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {On Hotelling's T² test in a special paired sample case},
  series = {Communications in Statistics - Theory and Methods},
  volume    = {48},
  journal   = {Communications in Statistics - Theory and Methods},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1532-415X},
  doi       = {10.1080/03610926.2017.1408828},
  pages     = {257 -- 267},
  year      = {2017},
  abstract  = {In a special paired sample case, Hotelling's T² test based on the differences of the paired random vectors is the likelihood ratio test for testing the hypothesis that the paired random vectors have the same mean; with respect to a special group of affine linear transformations it is the uniformly most powerful invariant test for the general alternative of a difference in mean. We present an elementary straightforward proof of this result. The likelihood ratio test for testing the hypothesis that the covariance structure is of the assumed special form is derived and discussed. Applications to real data are given.},
  language  = {en}
}
@article{BaringhausGaigall2017,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {Hotelling's T² tests in paired and independent survey samples: An efficiency comparison},
  series = {Journal of Multivariate Analysis},
  volume    = {2017},
  journal   = {Journal of Multivariate Analysis},
  number    = {154},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0047-259X},
  doi       = {10.1016/j.jmva.2016.11.004},
  pages     = {177 -- 198},
  year      = {2017},
  abstract  = {Hotelling's T² tests in paired and independent survey samples are compared using the traditional asymptotic efficiency concepts of Hodges-Lehmann, Bahadur and Pitman, as well as through criteria based on the volumes of corresponding confidence regions. Conditions characterizing the superiority of a procedure are given in terms of population canonical correlation type coefficients. Statistical tests for checking these conditions are developed. Test statistics based on the eigenvalues of a symmetrized sample cross-covariance matrix are suggested, as well as test statistics based on sample canonical correlation type coefficients.},
  language  = {en}
}
@article{Gaigall2023,
  author    = {Gaigall, Daniel},
  title     = {Allocating and forecasting changes in risk},
  series = {Journal of risk},
  volume    = {25},
  journal   = {Journal of risk},
  number    = {3},
  editor    = {AitSahlia, Farid},
  publisher = {Infopro Digital Risk},
  address   = {London},
  issn      = {1755-2842},
  doi       = {10.21314/JOR.2022.048},
  pages     = {1 -- 24},
  year      = {2023},
  abstract  = {We consider time-dependent portfolios and discuss the allocation of changes in the risk of a portfolio to changes in the portfolio's components. For this purpose we adopt established allocation principles. We also use our approach to obtain forecasts for changes in the risk of the portfolio's components. To put the approach into practice we present an implementation based on the output of a simulation. Allocation is illustrated with an example portfolio in the context of Solvency II. The quality of the forecasts is investigated with an empirical study.},
  language  = {en}
}
@article{Gaigall2023,
  author    = {Gaigall, Daniel},
  title     = {On the applicability of several tests to models with not identically distributed random effects},
  series = {Statistics : A Journal of Theoretical and Applied Statistics},
  volume    = {57},
  journal   = {Statistics : A Journal of Theoretical and Applied Statistics},
  publisher = {Taylor \& Francis},
  address   = {London},
  isbn      = {0323-3944},
  issn      = {1029-4910},
  doi       = {10.1080/02331888.2023.2193748},
  pages     = {14 Seiten},
  year      = {2023},
  abstract  = {We consider Kolmogorov-Smirnov and Cram{\´e}r-von-Mises type tests for testing central symmetry, exchangeability, and independence. In the standard case, the tests are intended for the application to independent and identically distributed data with unknown distribution. The tests are available for multivariate data and bootstrap procedures are suitable to obtain critical values. We discuss the applicability of the tests to random effects models, where the random effects are independent but not necessarily identically distributed and with possibly unknown distributions. Theoretical results show the adequacy of the tests in this situation. The quality of the tests in models with random effects is investigated by simulations. Empirical results obtained confirm the theoretical findings. A real data example illustrates the application.},
  language  = {en}
}
@article{GaigallGerstenberg2023,
  author    = {Gaigall, Daniel and Gerstenberg, Julian},
  title     = {Cram{\´e}r-von-Mises tests for the distribution of the excess over a confidence level},
  series = {Journal of Nonparametric Statistics},
  journal   = {Journal of Nonparametric Statistics},
  publisher = {Taylor \& Francis},
  issn      = {1048-5252 (Print)},
  doi       = {10.1080/10485252.2023.2173958},
  year      = {2023},
  abstract  = {The Cram{\´e}r-von-Mises distance is applied to the distribution of the excess over a confidence level. Asymptotics of related statistics are investigated, and it is seen that the obtained limit distributions differ from the classical ones. For that reason, quantiles of the new limit distributions are given and new bootstrap techniques for approximation purposes are introduced and justified. The results motivate new one-sample goodness-of-fit tests for the distribution of the excess over a confidence level and a new confidence interval for the related fitting error. Simulation studies investigate size and power of the tests as well as coverage probabilities of the confidence interval in the finite sample case. A practice-oriented application of the Cram{\´e}r-von-Mises tests is the determination of an appropriate confidence level for the fitting approach. The adoption of the idea to the well-known problem of threshold detection in the context of peaks over threshold modelling is sketched and illustrated by data examples.},
  language  = {en}
}
@article{LiphardtFernandezGonzaloAlbrachtetal.2023,
  author    = {Liphardt, Anna-Maria and Fernandez-Gonzalo, Rodrigo and Albracht, Kirsten and Rittweger, J{\"o}rn and Vico, Laurence},
  title     = {Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration},
  series = {npj Microgravity},
  volume    = {9},
  journal   = {npj Microgravity},
  number    = {Article number: 9},
  publisher = {Springer Nature},
  issn      = {2373-8065},
  doi       = {10.1038/s41526-023-00258-3},
  pages     = {1 -- 9},
  year      = {2023},
  abstract  = {Based on the European Space Agency (ESA) Science in Space Environment (SciSpacE) community White Paper "Human Physiology - Musculoskeletal system", this perspective highlights unmet needs and suggests new avenues for future studies in musculoskeletal research to enable crewed exploration missions. The musculoskeletal system is essential for sustaining physical function and energy metabolism, and the maintenance of health during exploration missions, and consequently mission success, will be tightly linked to musculoskeletal function. Data collection from current space missions from pre-, during-, and post-flight periods would provide important information to understand and ultimately offset musculoskeletal alterations during long-term spaceflight. In addition, understanding the kinetics of the different components of the musculoskeletal system in parallel with a detailed description of the molecular mechanisms driving these alterations appears to be the best approach to address potential musculoskeletal problems that future exploratory-mission crew will face. These research efforts should be accompanied by technical advances in molecular and phenotypic monitoring tools to provide in-flight real-time feedback.},
  language  = {en}
}
@article{RingersBialonskiEgeetal.2023,
  author    = {Ringers, Christa and Bialonski, Stephan and Ege, Mert and Solovev, Anton and Hansen, Jan Niklas and Jeong, Inyoung and Friedrich, Benjamin M. and Jurisch-Yaksi, Nathalie},
  title     = {Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia},
  series = {eLife},
  volume    = {12},
  journal   = {eLife},
  publisher = {eLife Sciences Publications},
  issn      = {2050-084X},
  doi       = {10.7554/eLife.77701},
  pages     = {27 Seiten},
  year      = {2023},
  abstract  = {Motile cilia are hair-like cell extensions that beat periodically to generate fluid flow along various epithelial tissues within the body. In dense multiciliated carpets, cilia were shown to exhibit a remarkable coordination of their beat in the form of traveling metachronal waves, a phenomenon which supposedly enhances fluid transport. Yet, how cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine experiments, novel analysis tools, and theory to address this knowledge gap. To investigate collective dynamics of cilia, we studied zebrafish multiciliated epithelia in the nose and the brain. We focused mainly on the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Even though synchronization is local only, we observed global patterns of traveling metachronal waves across the zebrafish multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right noses, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions, i.e., cilia colliding with each other, and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment coincide and generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.},
  language  = {en}
}
@article{BertzMolinnusSchoeningetal.2023,
  author    = {Bertz, Morten and Molinnus, Denise and Sch{\"o}ning, Michael Josef and Homma, Takayuki},
  title     = {Real-time monitoring of H₂O₂ sterilization on individual bacillus atrophaeus spores by optical sensing with trapping Raman spectroscopy},
  series = {Chemosensors},
  volume    = {8},
  journal   = {Chemosensors},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors11080445},
  pages     = {Artikel 445},
  year      = {2023},
  abstract  = {Hydrogen peroxide (H₂O₂), a strong oxidizer, is a commonly used sterilization agent employed during aseptic food processing and medical applications. To assess the sterilization efficiency with H₂O₂, bacterial spores are common microbial systems due to their remarkable robustness against a wide variety of decontamination strategies. Despite their widespread use, there is, however, only little information about the detailed time-resolved mechanism underlying the oxidative spore death by H₂O₂. In this work, we investigate chemical and morphological changes of individual Bacillus atrophaeus spores undergoing oxidative damage using optical sensing with trapping Raman microscopy in real-time. The time-resolved experiments reveal that spore death involves two distinct phases: (i) an initial phase dominated by the fast release of dipicolinic acid (DPA), a major spore biomarker, which indicates the rupture of the spore's core; and (ii) the oxidation of the remaining spore material resulting in the subsequent fragmentation of the spores' coat. Simultaneous observation of the spore morphology by optical microscopy corroborates these mechanisms. The dependence of the onset of DPA release and the time constant of spore fragmentation on H₂O₂ shows that the formation of reactive oxygen species from H₂O₂ is the rate-limiting factor of oxidative spore death.},
  language  = {en}
}
@article{WendlandtKochBritzetal.2023,
  author    = {Wendlandt, Tim and Koch, Claudia and Britz, Beate and Liedek, Anke and Schmidt, Nora and Werner, Stefan and Gleba, Yuri and Vahidpour, Farnoosh and Welden, Melanie and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System},
  series = {Viruses},
  volume    = {9},
  journal   = {Viruses},
  number    = {15},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1999-4915},
  doi       = {doi.org/10.3390/v15091951},
  pages     = {Artikel 1951},
  year      = {2023},
  abstract  = {Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes.},
  language  = {en}
}
@article{HerssensCowburnAlbrachtetal.2022,
  author    = {Herssens, Nolan and Cowburn, James and Albracht, Kirsten and Braunstein, Bjoern and Cazzola, Dario and Colyer, Steffi and Minetti, Alberto E. and Pavei, Gaspare and Rittweger, J{\"o}rn and Weber, Tobias and Green, David A.},
  title     = {Movement in low gravity environments (MoLo) programme - the MoLo-L.O.O.P. study protocol},
  series = {PLOS ONE / Public Library of Science},
  volume    = {17},
  journal   = {PLOS ONE / Public Library of Science},
  number    = {11},
  editor    = {Cattaneo, Luigi},
  publisher = {Plos},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0278051},
  pages     = {e0278051},
  year      = {2022},
  abstract  = {Exposure to prolonged periods in microgravity is associated with deconditioning of the musculoskeletal system due to chronic changes in mechanical stimulation. Given astronauts will operate on the Lunar surface for extended periods of time, it is critical to quantify both external (e.g., ground reaction forces) and internal (e.g., joint reaction forces) loads of relevant movements performed during Lunar missions. Such knowledge is key to predict musculoskeletal deconditioning and determine appropriate exercise countermeasures associated with extended exposure to hypogravity.},
  language  = {en}
}