@article{StadlerGarveyEmbsetal.2014,
  author    = {Stadler, Alexander Maximilian and Garvey, Christopher J. and Embs, Jan Peter and Koza, Michael Marek and Unruh, Tobias and Artmann, Gerhard and Zaccai, Guiseppe},
  title     = {Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study},
  series = {Biochimica et biophysica acta (BBA): General Subjects},
  volume    = {1840},
  journal   = {Biochimica et biophysica acta (BBA): General Subjects},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-8006 (E-Journal); 0304-4165 (Print)},
  doi       = {10.1016/j.bbagen.2014.06.007},
  pages     = {2989 -- 2999},
  year      = {2014},
  language  = {en}
}
@article{PfaffBurnham2009,
  author    = {Pfaff, Raphael and Burnham, Keith J.},
  title     = {On abstraction and interpretability: a behavioural perspective},
  series = {Systems Science},
  volume    = {Vol. 35},
  journal   = {Systems Science},
  number    = {Iss. 2},
  issn      = {0137-1223},
  pages     = {19 -- 26},
  year      = {2009},
  language  = {en}
}
@article{SeilerPichlerPfaffetal.2009,
  author    = {Seiler, Friedrich and Pichler, Alexander and Pfaff, Raphael and Srulijes, Julio},
  title     = {Novel processing tools for automated doppler picture velocimetry (DPV) evaluation},
  series = {Journal of visualization},
  volume    = {Vol. 12},
  journal   = {Journal of visualization},
  number    = {Iss. 4},
  issn      = {1343-8875},
  pages     = {323 -- 337},
  year      = {2009},
  language  = {en}
}
@article{YoshinobuMiyamotoWagneretal.2015,
  author    = {Yoshinobu, Tatsuo and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor},
  series = {Sensors and actuators B: Chemical},
  volume    = {207, Part B},
  journal   = {Sensors and actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3077 (E-Journal); 0925-4005 (Print)},
  doi       = {10.1016/j.snb.2014.09.002},
  pages     = {926 -- 932},
  year      = {2015},
  abstract  = {The light-addressable potentiometric sensor (LAPS) is an electrochemical sensor with a field-effect structure to detect the variation of the Nernst potential at its sensor surface, the measured area on which is defined by illumination. Thanks to this light-addressability, the LAPS can be applied to chemical imaging sensor systems, which can visualize the two-dimensional distribution of a particular target ion on the sensor surface. Chemical imaging sensor systems are expected to be useful for analysis of reaction and diffusion in various electrochemical and biological samples. Recent developments of LAPS-based chemical imaging sensor systems, in terms of the spatial resolution, measurement speed, image quality, miniaturization and integration with microfluidic devices, are summarized and discussed.},
  language  = {en}
}
@article{RatkeMilowLisinskietal.2014,
  author    = {Ratke, Lorenz and Milow, Barbara and Lisinski, Susanne and Hoepfner, Sandra},
  title     = {On an effect of fine ceramic particles on the structure of aerogels},
  series = {Microgravity science and technology},
  volume    = {26},
  journal   = {Microgravity science and technology},
  publisher = {Springer Nature},
  address   = {Heidelberg},
  issn      = {0938-0108 ; 1875-0494},
  doi       = {10.1007/s12217-014-9380-2},
  pages     = {103 -- 110},
  year      = {2014},
  language  = {en}
}
@article{MuribYeapMartensetal.2015,
  author    = {Murib, M. S. and Yeap, W. S. and Martens, D. and Liu, X. and Bienstman, P. and Fahlman, M. and Sch{\"o}ning, Michael Josef and Michiels, L. and Haenen, K. and Serpeng{\"u}zel, A. and Wagner, Patrick},
  title     = {Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands},
  series = {Sensors and actuators A: Physical},
  volume    = {222},
  journal   = {Sensors and actuators A: Physical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-3069 (E-Journal); 0924-4247 (Print)},
  doi       = {10.1016/j.sna.2014.11.024},
  pages     = {212 -- 219},
  year      = {2015},
  abstract  = {In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.},
  language  = {en}
}
@article{GuoSekiMiyamotoetal.2014,
  author    = {Guo, Yuanyuan and Seki, Kosuke and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Device simulation of the light-addressable potentiometric sensor with a novel photoexcitation method for a higher spatial resolution},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.369},
  pages     = {456 -- 459},
  year      = {2014},
  abstract  = {A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) realized a higher spatial resolution of chemical imaging. In this method, a modulated light probe, which generates the alternating photocurrent signal, is surrounded by a ring of constant light, which suppresses the lateral diffusion of photocarriers by enhancing recombination. A device simulation verified that a higher spatial resolution could be obtained by adjusting the gap between the modulated and constant light. It was also found that a higher intensity and a longer wavelength of constant light was more effective. However, there exists a tradeoff between the spatial resolution and the amplitude of the photocurrent, and thus, the signal-to-noise ratio. A tilted incidence of constant light was applied, which could achieve even higher resolution with a smaller loss of photocurrent.},
  language  = {en}
}
@article{MiyamotoSekiWagneretal.2014,
  author    = {Miyamoto, K. and Seki, K. and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, T.},
  title     = {Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.563},
  pages     = {612 -- 615},
  year      = {2014},
  abstract  = {The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm.},
  language  = {en}
}
@article{AlmajhdiSengerAmeretal.2014,
  author    = {Almajhdi, Fahad N. and Senger, Tilo and Amer, Haitham M. and Gissmann, Lutz and {\"O}hlschl{\"a}ger, Peter},
  title     = {Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)},
  series = {PLOS one},
  volume    = {11},
  journal   = {PLOS one},
  number    = {9},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0113461},
  pages     = {e113461},
  year      = {2014},
  abstract  = {Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.},
  language  = {en}
}
@article{MathiakPlescherWillnecker2005,
  author    = {Mathiak, Gerhard and Plescher, Engelbert and Willnecker, Rainer},
  title     = {Liquid metal diffusion experiments in microgravity - Vibrational effects},
  series = {Measurement science and technology},
  volume    = {Vol. 16},
  journal   = {Measurement science and technology},
  number    = {No. 2},
  issn      = {0957-0233},
  doi       = {10.1088/0957-0233/16/2/003},
  pages     = {336},
  year      = {2005},
  language  = {en}
}
@article{MathiakWillneckerPlescher2005,
  author    = {Mathiak, Gerhard and Willnecker, Rainer and Plescher, Engelbert},
  title     = {Vibrational effects on diffusion experiments},
  series = {Microgravity science and technology : international journal for microgravity research and applications},
  volume    = {Vol. 15},
  journal   = {Microgravity science and technology : international journal for microgravity research and applications},
  number    = {No. 1},
  issn      = {0938-0108},
  pages     = {295 -- 300},
  year      = {2005},
  language  = {en}
}
@article{FateriGebhardt2015,
  author    = {Fateri, Miranda and Gebhardt, Andreas},
  title     = {Selective Laser Melting of Soda-Lime Glass Powder},
  series = {International Journal of Applied Ceramic Technology},
  volume    = {12},
  journal   = {International Journal of Applied Ceramic Technology},
  number    = {1},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1744-7402},
  doi       = {10.1111/ijac.12338},
  pages     = {53 -- 61},
  year      = {2015},
  language  = {en}
}
@article{FateriGebhardt2015,
  author    = {Fateri, Miranda and Gebhardt, Andreas},
  title     = {Process Parameters Development of Selective Laser Melting of Lunar Regolith for On-Site Manufacturing Applications},
  series = {International Journal of Applied Ceramic Technology},
  volume    = {12},
  journal   = {International Journal of Applied Ceramic Technology},
  number    = {1},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  isbn      = {1744-7402},
  doi       = {10.1111/ijac.12326},
  pages     = {46 -- 52},
  year      = {2015},
  language  = {en}
}
@article{SchuetzWeissbeckerHummeletal.1997,
  author    = {Sch{\"u}tz, S. and Weißbecker, B. and Hummel, Hans E. and Sch{\"o}ning, Michael Josef and Riemer, A. and Kordos, P. and L{\"u}th, H.},
  title     = {Field effect transistor-insect antenna junction},
  series = {Naturwissenschaften},
  volume    = {84},
  journal   = {Naturwissenschaften},
  issn      = {1432-1904},
  pages     = {86 -- 88},
  year      = {1997},
  language  = {en}
}
@article{ThustSchoeningFrohnhoffetal.1996,
  author    = {Thust, Marion and Sch{\"o}ning, Michael Josef and Frohnhoff, S. and Arens-Fischer, R. and Kordos, P. and L{\"u}th, H.},
  title     = {Porous silicon as a substrate material for potentiometric biosensors},
  series = {Measurement Science and Technology},
  volume    = {7},
  journal   = {Measurement Science and Technology},
  number    = {1},
  doi       = {10.1088/0957-0233/7/1/003},
  pages     = {26 -- 29},
  year      = {1996},
  language  = {en}
}
@article{WagnerMiyamotoWerneretal.2011,
  author    = {Wagner, Torsten and Miyamoto, K. and Werner, Frederik and Sch{\"o}ning, Michael Josef and Yoshinobu, T.},
  title     = {Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS)},
  volume    = {9},
  number    = {2},
  publisher = {American Scientific Publishers},
  address   = {Stevenson Ranch, Calif.},
  doi       = {10.1166/sl.2011.1620},
  pages     = {812 -- 815},
  year      = {2011},
  language  = {en}
}
@article{MartinGonzalezKotliarRiosMartinezetal.2014,
  author    = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir},
  title     = {Mediated-reality magnification for macular degeneration rehabilitation},
  series = {Journal of Modern Optics},
  volume    = {61},
  journal   = {Journal of Modern Optics},
  number    = {17},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1362-3044},
  doi       = {10.1080/09500340.2014.936110},
  pages     = {1400 -- 1408},
  year      = {2014},
  language  = {en}
}
@article{KotliarKharoubiSchmidtTrucksaessetal.2009,
  author    = {Kotliar, Konstantin and Kharoubi, A. and Schmidt-Trucks{\"a}ß, A. and Halle, M. and Lanzl, I.},
  title     = {Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?},
  series = {Acta Ophthalmologica},
  volume    = {Vol. 87},
  journal   = {Acta Ophthalmologica},
  number    = {Suppl. S244},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)},
  pages     = {0},
  year      = {2009},
  language  = {en}
}
@article{WarmerWagnerSchoeningetal.2015,
  author    = {Warmer, Johannes and Wagner, Patrick and Sch{\"o}ning, Michael Josef and Kaul, Peter},
  title     = {Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431882},
  pages     = {1289 -- 1298},
  year      = {2015},
  language  = {en}
}
@article{DelleHuckBaeckeretal.2015,
  author    = {Delle, Lotta E. and Huck, Christina and B{\"a}cker, Matthias and M{\"u}ller, Frank and Grandthyll, Samuel and Jacobs, Karin and Lilischkis, Rainer and Vu, Xuan T. and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Thoelen, Roland and Weil, Maryam and Ingebrandt, Sven},
  title     = {Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431863},
  pages     = {1327 -- 1334},
  year      = {2015},
  language  = {en}
}
@article{SeiblerKleinriddersKueterLuksetal.2007,
  author    = {Seibler, Jost and Kleinridders, Andre and K{\"u}ter-Luks, Birgit and Niehaves, Sandra and Br{\"u}ning, Jens C. and Schwenk, Frieder},
  title     = {Reversible gene knockdown in mice using a tight, inducible shRNA expression system},
  series = {Nucleic Acids Research},
  volume    = {35},
  journal   = {Nucleic Acids Research},
  number    = {7},
  issn      = {1362-4962},
  doi       = {10.1093/nar/gkm122},
  pages     = {e54},
  year      = {2007},
  language  = {en}
}
@article{PlumMaHampeletal.2006,
  author    = {Plum, Leona and Ma, Xiaosong and Hampel, Brigitte and Balthasar, Nina and Coppari, Roberto and M{\"u}nzberg, Heike and Shanabrough, Marya and Burdakov, Denis and Rother, Eva and Janoschek, Ruth and Alber, Jens and Belgardt, Bengt F. and Koch, Linda and Seibler, Jost and Schenk, Frieder and Fekete, Csaba and Suzuki, Akira and Mak, Tak W. and Krone, Wilhelm and Horvath, Tamas L. and Ashcroft, Frances M. and Br{\"u}ning, Jens C.},
  title     = {Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity},
  series = {The Journal of Clinical Investigation (JCI)},
  volume    = {116},
  journal   = {The Journal of Clinical Investigation (JCI)},
  number    = {7},
  issn      = {1558-8238},
  doi       = {10.1172/JCI27123},
  pages     = {1886 -- 1901},
  year      = {2006},
  language  = {en}
}
@article{SeiblerKueterLuksKernetal.2005,
  author    = {Seibler, Jost and K{\"u}ter-Luks, Birgit and Kern, Heidrun and Streu, Sandra and Plum, Leona and Maurer, Jan and K{\"u}hn, Ralf and Br{\"u}ning, Jens C. and Schwenk, Frieder},
  title     = {Single copy shRNA configuration for ubiquitous gene knockdown in mice},
  series = {Nucleic Acids Research},
  volume    = {33},
  journal   = {Nucleic Acids Research},
  number    = {7},
  issn      = {1362-4962},
  doi       = {10.1093/nar/gni065},
  pages     = {e67},
  year      = {2005},
  language  = {en}
}
@article{SeiblerZevnikKueterLuksetal.2003,
  author    = {Seibler, Jost and Zevnik, Branko and K{\"u}ter-Luks, Birgit and Andreas, Susanne and Kern, Heidrun and Hennek, Thomas and Rode, Anja and Heimann, Cornelia and Faust, Nicole and Kauselmann, Gunther and Schoor, Michael and Jaenisch, Rudolf and Rajewsky, Klaus and K{\"u}hn, Ralf and Schwenk, Frieder},
  title     = {Rapid generation of inducible mouse mutants},
  series = {Nucleic Acids Research},
  volume    = {33},
  journal   = {Nucleic Acids Research},
  number    = {4},
  issn      = {1362-4962},
  doi       = {10.1093/nar/gng012},
  pages     = {e12},
  year      = {2003},
  language  = {en}
}
@article{GoetzeBaerWinkelmannetal.2005,
  author    = {Goetze, Sandra and Baer, Alexandra and Winkelmann, Silke and Nehlsen, Kristina and Seibler, Jost and Maass, Karin and Bode, J{\"u}rgen},
  title     = {Performance of genomic bordering elements at predefined genomic loci},
  series = {Molecular and Cellular Biology},
  volume    = {25},
  journal   = {Molecular and Cellular Biology},
  number    = {6},
  issn      = {1098-5549},
  doi       = {10.1128/MCB.25.6.2260-2272.2005},
  pages     = {2260 -- 2272},
  year      = {2005},
  language  = {en}
}
@article{YoshinobuMoritzFingeretal.2006,
  author    = {Yoshinobu, Tatsuo and Moritz, Werner and Finger, Friedhelm and Sch{\"o}ning, Michael Josef},
  title     = {Application of thin-film amorphous silicon to chemical imaging},
  series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.},
  journal   = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.},
  number    = {Paper 0910-A-20-01},
  editor    = {Comini, Elisabetta},
  isbn      = {9781558998711},
  pages     = {1 -- 10},
  year      = {2006},
  language  = {en}
}
@article{TakenagaSchneiderErbayetal.2015,
  author    = {Takenaga, Shoko and Schneider, Benno and Erbay, E. and Biselli, Manfred and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201532053},
  pages     = {1347 -- 1352},
  year      = {2015},
  abstract  = {A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.},
  language  = {en}
}
@article{InagakiSleddensLinkelsWassenaaretal.2011,
  author    = {Inagaki, Akiko and Sleddens-Linkels, Esther and Wassenaar, Evelyne and Ooms, Marja and Cappellen, Wiggert A. van and Hoeijmakers, Jan H. J. and Seibler, Jost and Vogt, Thomas F. and Shin, Myung K. and Grootegoed, J. Anton and Baarends, Willy M.},
  title     = {Meiotic functions of RAD18},
  series = {Journal of Cell Science},
  volume    = {124},
  journal   = {Journal of Cell Science},
  number    = {16},
  publisher = {Company of Biologists Limited},
  address   = {Cambridge},
  issn      = {1477-9137},
  doi       = {10.1242/jcs.081968},
  pages     = {2837 -- 2850},
  year      = {2011},
  language  = {en}
}
@article{RaabKappelKraemeretal.2011,
  author    = {Raab, Monika and Kappel, Sven and Kr{\"a}mer, Andrea and Sanhaji, Mourad and Matthess, Yves and Kurunci-Csacsko, Elisabeth and Calzada-Wack, Julia and Rathkolb, Birgit and Rosman, Jan and Adler, Thure and Busch, Dirk H. and Esposito, Irene and Fuchs, Helmut and Gailus-Durner, Val{\´e}rie and Klingenspor, Martin and Wolf, Eckhard and S{\"a}nger, Nicole and Prinz, Florian and Hrabe de Angelis, Martin and Seibler, Jost and Yuan, Juping and Bergmann, Martin and Knecht, Rainald and Kreft, Bertolt and Strebhardt, Klaus},
  title     = {Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells},
  series = {Nature Communications},
  volume    = {2},
  journal   = {Nature Communications},
  number    = {395},
  publisher = {Nature},
  address   = {London},
  issn      = {2041-1723},
  doi       = {10.1038/ncomms1395},
  pages     = {1 -- 11},
  year      = {2011},
  language  = {en}
}
@article{HasegawaKapelyukhTaharaetal.2011,
  author    = {Hasegawa, Maki and Kapelyukh, Yury and Tahara, Harunobu and Seibler, Jost and Rode, Anja and Krueger, Sylvia and Lee, Dongtao N. and Wolf, C. Roland and Scheer, Nico},
  title     = {Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line},
  series = {Molecular Pharmacology},
  volume    = {80},
  journal   = {Molecular Pharmacology},
  number    = {33},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.111.071845},
  pages     = {518 -- 528},
  year      = {2011},
  language  = {en}
}
@article{JordanKruegerWillmesetal.2011,
  author    = {Jordan, Sabine D. and Kr{\"u}ger, Markus and Willmes, Diana M. and Redemann, Nora and Wunderlich, F. Thomas and Br{\"o}nneke, Hella S. and Merkwirth, Carsten and Kashkar, Hamid and Olkkonen, Vesa M. and B{\"o}ttger, Thomas and Braun, Thomas and Seibler, Jost and Br{\"u}ning, Jens C.},
  title     = {Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism},
  series = {Nature Cell Biology},
  volume    = {13},
  journal   = {Nature Cell Biology},
  number    = {4},
  publisher = {Nature},
  address   = {New York},
  issn      = {1465-7392},
  doi       = {10.1038/ncb2211},
  pages     = {434 -- 446},
  year      = {2011},
  abstract  = {The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143-145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143-ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.},
  language  = {en}
}
@article{GlaserLubitzLovelandetal.2009,
  author    = {Glaser, Stefan and Lubitz, Sandra and Loveland, Kate L. and Ohbo, Kazu and Robb, Lorraine and Schwenk, Frieder and Seibler, Jost and Roellig, Daniela and Kranz, Andrea and Anastassiadis, Konstantinos and Stewart, A. Francis},
  title     = {The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis},
  series = {Epigenetics \& Chromatin},
  volume    = {2},
  journal   = {Epigenetics \& Chromatin},
  number    = {5},
  issn      = {1756-8935},
  doi       = {10.1186/1756-8935-2-5},
  pages     = {1 -- 16},
  year      = {2009},
  language  = {en}
}
@article{KotnikPopovaTodirasetal.2009,
  author    = {Kotnik, Katarina and Popova, Elena and Todiras, Mihail and Mori, Marcelo A. and Alenina, Natalia and Seibler, Jost and Bader, Michael},
  title     = {Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown},
  series = {Plos One},
  volume    = {4},
  journal   = {Plos One},
  number    = {4},
  publisher = {Plos},
  address   = {San Francisco, California, US},
  doi       = {10.1371/journal.pone.0005124},
  pages     = {e5124},
  year      = {2009},
  language  = {en}
}
@article{HeroldBrandtSeibleretal.2008,
  author    = {Herold, Marco J. and Brandt, Jens van den and Seibler, Jost and Reichardt, Holger M.},
  title     = {Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats},
  series = {Proceedings of the National Academy of Sciences of the United States of America},
  volume    = {105},
  journal   = {Proceedings of the National Academy of Sciences of the United States of America},
  number    = {47},
  issn      = {1091-6490},
  doi       = {10.1073/pnas.0806213105},
  pages     = {18507 -- 18512},
  year      = {2008},
  language  = {en}
}
@article{KochWunderlichSeibleretal.2008,
  author    = {Koch, Linda and Wunderlich, F. Thomas and Seibler, Jost and K{\"o}nner, A. Christine and Hampel, Brigitte and Irlenbusch, Sigrid and Brabant, Georg and Kahn, C. Ronald and Schwenk, Frieder and Br{\"u}ning, Jens C.},
  title     = {Central insulin action regulates peripheral glucose and fat metabolism in mice},
  series = {The Journal of Clinical Investigation (JCI)},
  volume    = {118},
  journal   = {The Journal of Clinical Investigation (JCI)},
  number    = {6},
  issn      = {1558-8238},
  doi       = {10.1172/JCI31073},
  pages     = {2132 -- 2147},
  year      = {2008},
  language  = {en}
}
@article{ChristophBahrenbergVryetal.2008,
  author    = {Christoph, Thomas and Bahrenberg, Gregor and Vry, Jean de and Englberger, Werner and Erdmann, Volker A. and Frech, Moritz and K{\"o}gel, Babette and R{\"o}hl, Thomas and Schiene, Klaus and Schr{\"o}der, Wolfgang and Seibler, Jost and Kurreck, Jens},
  title     = {Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice},
  series = {Molecular and Cellular Neuroscience},
  volume    = {37},
  journal   = {Molecular and Cellular Neuroscience},
  number    = {3},
  issn      = {1044-7431},
  doi       = {10.1016/j.mcn.2007.12.006},
  pages     = {579 -- 589},
  year      = {2008},
  language  = {en}
}
@article{CesariRennekampffVinterstenetal.2004,
  author    = {Cesari, Francesca and Rennekampff, Verena and Vintersten, Kristina and Vuong, Lam Giang and Seibler, Jost and Bode, J{\"u}rgen and Wiebel, Franziska F. and Nordheim, Alfred},
  title     = {Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange},
  series = {Genesis : The Journal of Genetics and Development},
  volume    = {38},
  journal   = {Genesis : The Journal of Genetics and Development},
  number    = {2},
  issn      = {1526-968X},
  doi       = {10.1002/gene.20003},
  pages     = {87 -- 92},
  year      = {2004},
  language  = {en}
}
@article{BodeSchlakeIberetal.2000,
  author    = {Bode, J{\"u}rgen and Schlake, Thomas and Iber, Michaela and Sch{\"u}beler, Dirk and Seibler, Jost and Snezhkov, Evgeney and Nikolaev, Lev},
  title     = {The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes},
  series = {Biological Chemistry},
  volume    = {381},
  journal   = {Biological Chemistry},
  number    = {9-10},
  issn      = {1431-6730},
  doi       = {10.1515/BC.2000.103},
  pages     = {801 -- 813},
  year      = {2000},
  language  = {en}
}
@article{FengSeiblerAlamietal.1999,
  author    = {Feng, Yong-Qing and Seibler, Jost and Alami, Raouf and Eisen, Andrew and Westerman, Karen A. and Leboulch, Philippe and Fiering, Steven and Bouhassira, Eric E.},
  title     = {Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange},
  series = {Journal of Molecular Biology},
  volume    = {292},
  journal   = {Journal of Molecular Biology},
  number    = {4},
  issn      = {0022-2836},
  doi       = {10.1006/jmbi.1999.3113},
  pages     = {779 -- 785},
  year      = {1999},
  language  = {en}
}
@article{SeiblerSchuebelerFieringetal.1998,
  author    = {Seibler, Jost and Sch{\"u}beler, Dirk and Fiering, Steven and Groudine, Mark and Bode, J{\"u}rgen},
  title     = {DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs},
  series = {Biochemistry},
  volume    = {37},
  journal   = {Biochemistry},
  number    = {18},
  issn      = {1520-4995},
  doi       = {10.1021/bi980288t},
  pages     = {6229 -- 6234},
  year      = {1998},
  language  = {en}
}
@article{SeiblerBode1997,
  author    = {Seibler, Jost and Bode, J{\"u}rgen},
  title     = {Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay},
  series = {Biochemistry},
  volume    = {36},
  journal   = {Biochemistry},
  number    = {7},
  issn      = {1520-4995},
  pages     = {1740 -- 1747},
  year      = {1997},
  language  = {en}
}
@article{BodeBartschBoulikasetal.1998,
  author    = {Bode, J. and Bartsch, J. and Boulikas, T. and Iber, M. and Mielke, C. and Sch{\"u}beler, D. and Seibler, Jost and Benham, C.},
  title     = {Transcription-promoting genomic sites in mammalia: their elucidation and architectural principles},
  series = {Gene therapy \& molecular biology},
  volume    = {1},
  journal   = {Gene therapy \& molecular biology},
  number    = {1},
  issn      = {1529-9120},
  pages     = {1 -- 29},
  year      = {1998},
  language  = {en}
}
@article{IberSchuebelerSeibleretal.1998,
  author    = {Iber, Michaela and Sch{\"u}beler, Dirk and Seibler, Jost and H{\"o}xter, Maria and Bode, J{\"u}rgen},
  title     = {Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions},
  series = {Technical Tips Online},
  volume    = {4},
  journal   = {Technical Tips Online},
  number    = {1},
  doi       = {10.1016/S1366-2120(08)70132-6},
  pages     = {25 -- 29},
  year      = {1998},
  language  = {en}
}
@article{HenkenOosterhuisOehlschlaegeretal.2012,
  author    = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.},
  title     = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7},
  series = {Vaccine},
  volume    = {30},
  journal   = {Vaccine},
  number    = {28},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0264-410X},
  doi       = {10.1016/j.vaccine.2012.04.013},
  pages     = {4259 -- 4266},
  year      = {2012},
  abstract  = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.},
  language  = {en}
}
@article{ImmelGruetzkeSpaeteetal.2012,
  author    = {Immel, Timo and Gr{\"u}tzke, Martin and Sp{\"a}te, Anne-Katrin and Groth, Ulrich and {\"O}hlschl{\"a}ger, Peter and Huhn, Thomas},
  title     = {Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy},
  series = {Chemical Communications},
  volume    = {48},
  journal   = {Chemical Communications},
  number    = {46},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  issn      = {1364-548X},
  doi       = {10.1039/C2CC31624B},
  pages     = {5790 -- 5792},
  year      = {2012},
  abstract  = {Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.},
  language  = {en}
}
@article{FellinKingKirschetal.2010,
  author    = {Fellin, Wolfgang and King, Julian and Kirsch, Ansgar and Oberguggenberger, Michael},
  title     = {Uncertainty modelling and sensitivity analysis of tunnel face stability},
  series = {Structural safety},
  volume    = {32},
  journal   = {Structural safety},
  number    = {6},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0167-4730},
  doi       = {10.1016/j.strusafe.2010.06.001},
  pages     = {402 -- 410},
  year      = {2010},
  abstract  = {This paper proposes an approach to the choice and evaluation of engineering models with the aid of a typical application in geotechnics. An important issue in the construction of shallow tunnels, especially in weak ground conditions, is the tunnel face stability. Various theoretical and numerical models for predicting the necessary support pressure have been put forth in the literature. In this paper, we combine laboratory experiments performed at the University of Innsbruck with current methods of uncertainty and sensitivity analysis for assessing adequacy, predictive power and robustness of the models. The major issues are the handling of the twofold uncertainty of test results and of model predictions as well as the decision about what are the influential input parameters.},
  language  = {en}
}
@article{Kirsch2010,
  author    = {Kirsch, Ansgar},
  title     = {Experimental investigation of the face stability of shallow tunnels in sand},
  series = {Acta Geotechnica},
  volume    = {5},
  journal   = {Acta Geotechnica},
  number    = {1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1861-1125},
  doi       = {10.1007/s11440-010-0110-7},
  pages     = {43 -- 62},
  year      = {2010},
  abstract  = {Various models have been proposed for the prediction of the necessary support pressure at the face of a shallow tunnel. To assess their quality, the collapse of a tunnel face was modelled with small-scale model tests at single gravity. The development of the failure mechanism and the support force at the face in dry sand were investigated. The observed displacement patterns show a negligible influence of overburden on the extent and evolution of the failure zone. The latter is significantly influenced, though, by the initial density of the sand: in dense sand a chimney-wedge-type collapse mechanism developed, which propagated towards the soil surface. Initially, loose sand did not show any discrete collapse mechanism. The necessary support force was neither influenced by the overburden nor the initial density. A comparison with quantitative predictions by several theoretical models showed that the measured necessary support pressure is overestimated by most of the models. Those by Vermeer/Ruse and L{\´e}ca/Dormieux showed the best agreement to the measurements.},
  language  = {en}
}
@article{KolymbasFellinKirsch2006,
  author    = {Kolymbas, Dimitrios and Fellin, W. and Kirsch, Ansgar},
  title     = {Squeezing due to stress relaxation in foliated rock},
  series = {International journal for numerical and analytical methods in geomechanics},
  volume    = {Vol. 30},
  journal   = {International journal for numerical and analytical methods in geomechanics},
  number    = {Iss. 13},
  issn      = {1096-9853 (E-Journal); 0363-9061 (Print)},
  doi       = {10.1002/nag.530},
  pages     = {1357 -- 1367},
  year      = {2006},
  language  = {en}
}
@article{ScheerSnaithWolfetal.2013,
  author    = {Scheer, Nico and Snaith, Mike and Wolf, C. Roland and Seibler, Jost},
  title     = {Generation and utility of genetically humanized mouse models},
  series = {Drug Discovery Today},
  volume    = {Vol 18},
  journal   = {Drug Discovery Today},
  number    = {23-24},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1359-6446},
  doi       = {10.1016/j.drudis.2013.07.007},
  pages     = {1200 -- 1211},
  year      = {2013},
  language  = {en}
}
@article{BouwmanGuldenHeijdenetal.2013,
  author    = {Bouwman, Peter and Gulden, Hanneke van der and Heijden, Ingrid van der and Drost, Rinske and Klijn, Christiaan N. and Prasetyanti, Pramudita and Pieterse, Mark and Wientjens, Ellen and Seibler, Jost and Hogervorst, Frank B. L. and Jonkers, Jos},
  title     = {A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants},
  series = {Cancer Discovery},
  journal   = {Cancer Discovery},
  number    = {3},
  issn      = {2159-8290},
  doi       = {10.1158/2159-8290.CD-13-0094},
  pages     = {1142 -- 1152},
  year      = {2013},
  language  = {en}
}