@article{BassamHeschelerTemizArtmannetal.2012, author = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya}, title = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin}, series = {BMC Biophysics}, volume = {5}, journal = {BMC Biophysics}, publisher = {BioMed Central}, address = {London}, issn = {2046-1682}, doi = {10.1186/2046-1682-5-16}, pages = {Art. 16}, year = {2012}, abstract = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.}, language = {en} } @article{Wolf2000, author = {Wolf, Martin R.}, title = {Groupware related task design}, series = {ACM SIGGROUP Bulletin}, volume = {21}, journal = {ACM SIGGROUP Bulletin}, number = {2}, issn = {2372-7403}, doi = {10.1145/605660.605662}, pages = {5 -- 8}, year = {2000}, abstract = {his report summarizes the results of a workshop on Groupware related task design which took place at the International Conference on Supporting Group Work Group'99, Arizona, from 14 th to 17 th November 1999. The workshop was addressed to people from different viewpoints, backgrounds, and domains: - Researchers dealing with questions of task analysis and task modeling for Groupware application from an academic point of view. They may contribute modelbased design approaches or theoretically oriented work - Practitioners with experience in the design and everyday use of groupware systems. They might refer to the practical side of the topic: "real" tasks, "real" problems, "real" users, etc.}, language = {en} } @article{MansurovDigelBiisenbaevetal.2012, author = {Mansurov, Z. and Digel, Ilya and Biisenbaev, M. and Savistkaya, I. and Kistaubaeva, A. and Akimbekov, Nuraly S. and Zhubanova, A.}, title = {Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications}, series = {Eurasian Chemico-Technological Journal}, volume = {14}, journal = {Eurasian Chemico-Technological Journal}, number = {2}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {2522-4867}, doi = {10.18321/ectj105}, pages = {115 -- 131}, year = {2012}, language = {en} } @article{ScholzRomagnoliDachwaldetal.2011, author = {Scholz, Christina and Romagnoli, Daniele and Dachwald, Bernd and Theil, Stephan}, title = {Performance analysis of an attitude control system for solar sails using sliding masses}, series = {Advances in Space Research}, volume = {48}, journal = {Advances in Space Research}, number = {11}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, pages = {1822 -- 1835}, year = {2011}, language = {en} } @article{LeipoldFichtnerHeberetal.2006, author = {Leipold, M. and Fichtner, H. and Heber, B. and Groepper, P. and Lascar, S. and Burger, F. and Eiden, M. and Niederstadt, T. and Sickinger, C. and Herbeck, L. and Dachwald, Bernd and Seboldt, Wolfgang}, title = {Heliopause Explorer - A Sailcraft Mission to the Outer Boundaries of the Solar System}, series = {Acta Astronautica. 59 (2006), H. 8-11}, journal = {Acta Astronautica. 59 (2006), H. 8-11}, isbn = {0094-5765}, pages = {786 -- 796}, year = {2006}, language = {en} } @article{DachwaldTuryshevDittusetal.2005, author = {Dachwald, Bernd and Turyshev, Slava G. and Dittus, H. and Shao, M. [u.a.]}, title = {Fundamental Physics with the Laser Astrometric Test Of Relativity / S.G. Turyshev ; H. Dittus ; M. Shao ... B.Dachwald ...}, series = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)}, journal = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)}, publisher = {ESA Publ. Div.}, address = {Noordwijk}, isbn = {9290928999}, pages = {8 -- 11}, year = {2005}, language = {en} } @article{DittusTuryshevDachwaldetal.2005, author = {Dittus, H. and Turyshev, S. G. and Dachwald, Bernd and Blome, Hans-Joachim}, title = {A Mission to Explore the Pioneer Anomaly}, series = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)}, journal = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)}, publisher = {ESA Publ. Div.}, address = {Noordwijk}, isbn = {9290928999}, pages = {3 -- 10}, year = {2005}, language = {en} } @article{DachwaldMacDonaldMcInnes2007, author = {Dachwald, Bernd and MacDonald, Malcolm and McInnes, Colin R.}, title = {Heliocentric Solar Sail Orbit Transfers with Locally Optimal Control Laws / Malcolm Macdonald ; Colin McInnes ; Bernd Dachwald}, series = {Journal of Spacecraft and Rockets. 44 (2007), H. 1}, journal = {Journal of Spacecraft and Rockets. 44 (2007), H. 1}, isbn = {0022-4650}, pages = {273 -- 276}, year = {2007}, language = {en} } @article{DachwaldSeboldt2005, author = {Dachwald, Bernd and Seboldt, Wolfgang}, title = {Solar Sails for Near- and Medium-Term Scientific Deep Space Missions / W. Sebolt ; B. Dachwald}, series = {In-space propulsion : edited book of proceedings of the 10-IWCP, the 10th International Workshop on Combustion and Propulsion held in Lerici, La Spezia, Italy, 21-25 September 2003 / [ed.: Luigi T. DeLuca]}, journal = {In-space propulsion : edited book of proceedings of the 10-IWCP, the 10th International Workshop on Combustion and Propulsion held in Lerici, La Spezia, Italy, 21-25 September 2003 / [ed.: Luigi T. DeLuca]}, publisher = {SP Lab, Politecnico di Milano}, address = {Milano}, pages = {getr. Z{\"a}hlung . Ill.}, year = {2005}, language = {en} } @article{DachwaldCarnelliVasile2006, author = {Dachwald, Bernd and Carnelli, I. and Vasile, M.}, title = {Evolutionary Neurocontrol as a Novel Method for Low-Thrust Gravity Assist Trajectory Optimization / I. Carnelli ; B. Dachwald ; M. Vasile}, series = {Proceedings of the Twenty-Fifth International Symposium on Space Technology and Science (Selected papers) : Kanazawa, [June 4 through June 11, 2006, at Kanazawa-shi Kanko Kaikan in Kanazawa city] / [Japan Society for Aeronautical and Space Sciences. Kohtaro Matsumoto [ed.-in-chief]}, journal = {Proceedings of the Twenty-Fifth International Symposium on Space Technology and Science (Selected papers) : Kanazawa, [June 4 through June 11, 2006, at Kanazawa-shi Kanko Kaikan in Kanazawa city] / [Japan Society for Aeronautical and Space Sciences. Kohtaro Matsumoto [ed.-in-chief]}, publisher = {JSASS}, address = {Tokyo}, isbn = {4-99005-002-9}, pages = {569 -- 574}, year = {2006}, language = {en} } @article{DachwaldCarnelliVasile2006, author = {Dachwald, Bernd and Carnelli, I. and Vasile, M.}, title = {Low-Thrust Gravity Assist Trajectory Optimization Using Evolutionary Neurocontrollers / I. Carnelli ; B. Dachwald ; M. Vasile ...}, series = {Astrodynamics 2005 : proceedings of the AAS/AIAA astrodynamics conference held August 7 - 11, 2005, South Lake Tahoe, California / ed. by Bobby G. Williams. - Pt. 3. - (Advances in the astronautical sciences ; 123,3)}, journal = {Astrodynamics 2005 : proceedings of the AAS/AIAA astrodynamics conference held August 7 - 11, 2005, South Lake Tahoe, California / ed. by Bobby G. Williams. - Pt. 3. - (Advances in the astronautical sciences ; 123,3)}, publisher = {Univelt}, address = {San Diego, Calif.}, isbn = {0-87703-527-X}, pages = {1911 -- 1928}, year = {2006}, language = {en} } @article{DachwaldLeipoldFichtner2003, author = {Dachwald, Bernd and Leipold, M. and Fichtner, H.}, title = {Heliopause Explorer - A Sailcraft Mission to the Outer Boundaries of the Solar System / M. Leipold ; H. Fichtner ; B. Heber ... B. Dachwald ...}, series = {Proceedings of the Fifth IAA International Conference on Low Cost Planetary Missions : 24 - 26 September 2003, ESTEC, Noordwijk, the Netherlands / [comp. by R. A. Harris]}, journal = {Proceedings of the Fifth IAA International Conference on Low Cost Planetary Missions : 24 - 26 September 2003, ESTEC, Noordwijk, the Netherlands / [comp. by R. A. Harris]}, publisher = {ESA}, address = {Noordwijk}, isbn = {92-9092-853-0}, pages = {367 -- 375}, year = {2003}, language = {en} } @article{ErpicumCrookstonBombardellietal.2021, author = {Erpicum, Sebastien and Crookston, Brian M. and Bombardelli, Fabian and Bung, Daniel Bernhard and Felder, Stefan and Mulligan, Sean and Oertel, Mario and Palermo, Michele}, title = {Hydraulic structures engineering: An evolving science in a changing world}, series = {Wires Water}, volume = {8}, journal = {Wires Water}, number = {2}, publisher = {Wiley}, address = {Weinheim}, issn = {2049-1948}, doi = {10.1002/wat2.1505}, year = {2021}, language = {en} } @article{Dachwald2004, author = {Dachwald, Bernd}, title = {Interplanetary Mission Analysis for Non-Perfectly Reflecting Solar Sailcraft Using Evolutionary Neurocontrol}, series = {Astrodynamics 2003 : proceedings of the AAS/AIAA Astrodynamics Conference held August 3 - 7, 2003, Big Sky, Montana / ed. by Jean de Lafontaine. - Pt. 2. - (Advances in the astronautical sciences ; 116,2)}, journal = {Astrodynamics 2003 : proceedings of the AAS/AIAA Astrodynamics Conference held August 3 - 7, 2003, Big Sky, Montana / ed. by Jean de Lafontaine. - Pt. 2. - (Advances in the astronautical sciences ; 116,2)}, publisher = {Univelt}, address = {San Diego, Calif.}, isbn = {0-87703-509-1}, pages = {1247 -- 1262}, year = {2004}, language = {en} } @article{DachwaldSeboldt2002, author = {Dachwald, Bernd and Seboldt, Wolfgang}, title = {Optimization of Interplanetary Rendezvous Trajectories for Solar Sailcraft Using a Neurocontroller}, series = {A collection of technical papers / AIAA Astrodynamics Specialist Conference : Monterey, California, 5 - 8 August 2002. - Vol. 2}, journal = {A collection of technical papers / AIAA Astrodynamics Specialist Conference : Monterey, California, 5 - 8 August 2002. - Vol. 2}, publisher = {American Institute of Aeronautics and Astronautics}, address = {Reston, Va.}, isbn = {1-56347-549-9}, pages = {1263 -- 1270}, year = {2002}, language = {en} } @article{StaatTranKreissig2008, author = {Staat, Manfred and Tran, Thanh Ngoc and Kreißig, R.}, title = {Load bearing capacity of thin shell structures made of elastoplastic material by direct methods}, series = {Technische Mechanik. 28 (2008), H. 3-4}, journal = {Technische Mechanik. 28 (2008), H. 3-4}, pages = {299 -- 309}, year = {2008}, language = {en} } @article{HeuermannStolleSchiek1995, author = {Heuermann, Holger and Stolle, Reinhard and Schiek, Burkhard}, title = {Novel Algorithms for FMCW Range Finding with Microwaves. Stolle, R.; Heuermann, H.; Schiek, B.}, pages = {129 -- 132}, year = {1995}, language = {en} } @article{HeuermannBaumannFauthetal.1994, author = {Heuermann, Holger and Baumann, F.-M. and Fauth, G. and Albert, M.}, title = {Results of Network Analyzer Measurements with Leakage Errors Corrected with the TMS-15-Term Procedure}, series = {On-Line Moisture Analysis of Raw Coal}, journal = {On-Line Moisture Analysis of Raw Coal}, pages = {1361 -- 1364}, year = {1994}, language = {en} } @article{StaatBallmann1988, author = {Staat, Manfred and Ballmann, J.}, title = {Wave Propagation and Focussing in Plates}, series = {Impact loading and dynamic behaviour of materials : Papers presented at the International Conference on Impact Loading and Dynamic Behaviour of Materials, Vol. 2 / Chiem, C. Y.; Kunze, L. (u.a.) [eds]}, journal = {Impact loading and dynamic behaviour of materials : Papers presented at the International Conference on Impact Loading and Dynamic Behaviour of Materials, Vol. 2 / Chiem, C. Y.; Kunze, L. (u.a.) [eds]}, publisher = {DGM Informationsges.}, address = {Oberursel}, year = {1988}, language = {en} } @article{TippkoetterStueckmannKrolletal.2009, author = {Tippk{\"o}tter, Nils and St{\"u}ckmann, Henning and Kroll, Stephen and Winkelmann, Gunda and Noack, Udo and Scheper, Thomas and Ulber, Roland}, title = {A semi-quantitative dipstick assay for microcystin}, series = {Analytical and Bioanalytical Chemistry}, volume = {394}, journal = {Analytical and Bioanalytical Chemistry}, number = {3}, publisher = {springer}, address = {Berlin}, issn = {1618-2650}, doi = {10.1007/s00216-009-2750-8}, pages = {863 -- 869}, year = {2009}, abstract = {An immunochromatographic lateral flow dipstick assay for the fast detection of microcystin-LR was developed. Colloid gold particles with diameters of 40 nm were used as red-colored antibody labels for the visual detection of the antigen. The new dipstick sensor is capable of detecting down to 5 µg·l-1 (ppb; total inversion of the color signal) or 1 ppb (observation of color grading) of microcystin-LR. The course of the labeling reaction was observed via spectrometric wave shifts caused by the change of particle size during the binding of antibodies. Different stabilizing reagents showed that especially bovine serum albumin (BSA) and casein increase the assays sensitivity and the conjugate stability. Performance of the dipsticks was quantified by pattern processing of capture zone CCD images. Storage stability of dipsticks and conjugate suspensions over 115 days under different conditions were monitored. The ready-to-use dipsticks were successfully tested with microcystin-LR-spiked samples of outdoor drinking- and salt water and applied to the tissue of microcystin-fed mussels.}, language = {en} } @article{TranPhamVuetal.2009, author = {Tran, Thanh Ngoc and Pham, Phu Tinh and Vu, D. K. and Staat, Manfred}, title = {Reliability Analysis of Inelastic Shell Structures Under Variable Loads}, series = {Limit States of Materials and Structures : Direct Methods / Hrsg. Dieter Weichert; Hrsg. Alan Ponter}, journal = {Limit States of Materials and Structures : Direct Methods / Hrsg. Dieter Weichert; Hrsg. Alan Ponter}, publisher = {Springer Netherland}, address = {Berlin}, isbn = {978-1-4020-9633-4}, pages = {135 -- 156}, year = {2009}, language = {en} } @article{NiemuellerLakemeyerFerreinetal.2013, author = {Niem{\"u}ller, Tim and Lakemeyer, Gerhard and Ferrein, Alexander and Reuter, S. and Ewert, D. and Jeschke, S. and Pensky, D. and Karras, Ulrich}, title = {Proposal for advancements to the LLSF in 2014 and beyond}, pages = {Publ. online}, year = {2013}, language = {en} } @article{Laack2013, author = {Laack, Walter van}, title = {The genetic code should be seen as a positioning code}, series = {British journal of arts and social sciences. Vol. 14 (2013), No. 1}, journal = {British journal of arts and social sciences. Vol. 14 (2013), No. 1}, issn = {2046-9578}, pages = {93 -- 97}, year = {2013}, language = {en} } @article{HeuermannSchiek1994, author = {Heuermann, Holger and Schiek, Burkhard}, title = {Results of Network Analyzer Measurements with Leakage Errors Corrected with the TMS-15-Term Procedure}, pages = {1361 -- 1364}, year = {1994}, language = {en} } @article{SchoppBritunVoracetal.2019, author = {Schopp, Christoph and Britun, Nikolay and Vorac, Jan and Synek, Petr and Snyders, Rony and Heuermann, Holger}, title = {Thermal and Optical Study on the Frequency Dependence of an Atmospheric Microwave Argon Plasma Jet}, series = {IEEE Transactions on Plasma Science}, volume = {47}, journal = {IEEE Transactions on Plasma Science}, number = {7}, publisher = {IEEE}, address = {New York}, issn = {1939-9375}, pages = {3176 -- 3181}, year = {2019}, language = {en} } @article{StaatHeitzer1999, author = {Staat, Manfred and Heitzer, M.}, title = {Structural Reliability Analysis of Elasto-Plastic Structures}, series = {Safety and reliability : proceedings of ESREL '99, the Tenth European Conference on Safety and Reliability, Munich-Garching, Germany, 13 - 17 September 1999 / Schu{\"e}ller, G. I.; Kafka, P. [eds]}, journal = {Safety and reliability : proceedings of ESREL '99, the Tenth European Conference on Safety and Reliability, Munich-Garching, Germany, 13 - 17 September 1999 / Schu{\"e}ller, G. I.; Kafka, P. [eds]}, publisher = {Balkema}, address = {Rotterdam}, isbn = {90-5809-109-0}, pages = {513 -- 518}, year = {1999}, language = {en} } @article{ButenwegBursiPaolaccietal.2021, author = {Butenweg, Christoph and Bursi, Oreste S. and Paolacci, Fabrizio and Marinković, Marko and Lanese, Igor and Nardin, Chiara and Quinci, Gianluca}, title = {Seismic performance of an industrial multi-storey frame structure with process equipment subjected to shake table testing}, series = {Engineering Structures}, volume = {243}, journal = {Engineering Structures}, number = {15}, editor = {Yang, J.}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0141-0296}, doi = {10.1016/j.engstruct.2021.112681}, year = {2021}, abstract = {Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of process equipment and multiple and simultaneous release of hazardous substances. Nonetheless, current standards for seismic design of industrial facilities are considered inadequate to guarantee proper safety conditions against exceptional events entailing loss of containment and related consequences. On these premises, the SPIF project -Seismic Performance of Multi-Component Systems in Special Risk Industrial Facilities- was proposed within the framework of the European H2020 SERA funding scheme. In detail, the objective of the SPIF project is the investigation of the seismic behaviour of a representative industrial multi-storey frame structure equipped with complex process components by means of shaking table tests. Along this main vein and in a performance-based design perspective, the issues investigated in depth are the interaction between a primary moment resisting frame (MRF) steel structure and secondary process components that influence the performance of the whole system; and a proper check of floor spectra predictions. The evaluation of experimental data clearly shows a favourable performance of the MRF structure, some weaknesses of local details due to the interaction between floor crossbeams and process components and, finally, the overconservatism of current design standards w.r.t. floor spectra predictions.}, language = {en} } @article{KleefeldReissel2011, author = {Kleefeld, Andreas and Reißel, Martin}, title = {The Levenberg-Marquardt method applied to a parameter estimation problem arising from electrical resistivity tomography}, series = {Applied Mathematics and Computation}, volume = {217}, journal = {Applied Mathematics and Computation}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0096-3003}, pages = {4490 -- 4501}, year = {2011}, language = {en} } @article{HacklNacovKammerlohretal.2021, author = {Hackl, Michael and Nacov, Julia and Kammerlohr, Sandra and Staat, Manfred and Buess, Eduard and Leschinger, Tim and M{\"u}ller, Lars P. and Wegmann, Kilian}, title = {Intratendinous Strain Variations of the Supraspinatus Tendon Depending on Repair Technique: A Biomechanical Analysis Regarding the Cause of Medial Cuff Failure}, series = {The American Journal of Sports Medicine}, volume = {49}, journal = {The American Journal of Sports Medicine}, number = {7}, publisher = {Sage}, address = {London}, issn = {1552-3365}, doi = {10.1177/03635465211006138}, pages = {1847 -- 1853}, year = {2021}, language = {en} } @article{StadlerEmbsDigeletal.2008, author = {Stadler, Andreas M. and Embs, Jan P. and Digel, Ilya and Artmann, Gerhard and Unruh, Tobias and B{\"u}ldt, Georg and Zaccai, Guiseppe}, title = {Cytoplasmic water and hydration layer dynamics in human red blood cells}, series = {Journal of the American Chemical Society. 50 (2008), H. 130}, journal = {Journal of the American Chemical Society. 50 (2008), H. 130}, isbn = {1520-5126}, pages = {16852 -- 16853}, year = {2008}, language = {en} } @article{MuschallikMolinnusJablonskietal.2020, author = {Muschallik, Lukas and Molinnus, Denise and Jablonski, Melanie and Kipp, Carina Ronja and Bongaerts, Johannes and Pohl, Martina and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Selmer, Thorsten and Siegert, Petra}, title = {Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase}, series = {RSC Advances}, volume = {10}, journal = {RSC Advances}, publisher = {Royal Society of Chemistry (RSC)}, address = {Cambridge}, issn = {2046-2069}, doi = {10.1039/D0RA02066D}, pages = {12206 -- 12216}, year = {2020}, abstract = {α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated.}, language = {en} } @article{HorbachStaatPerezVianaetal.2020, author = {Horbach, Andreas and Staat, Manfred and Perez-Viana, Daniel and Simmen, Hans-Peter and Neuhaus, Valentin and Pape, Hans-Christoph and Prescher, Andreas and Ciritsis, Bernhard}, title = {Biomechanical in vitro examination of a standardized low-volume tubular femoroplasty}, series = {Clinical Biomechanics}, volume = {80}, journal = {Clinical Biomechanics}, number = {Art. 105104}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.clinbiomech.2020.105104}, year = {2020}, abstract = {Background Osteoporosis is associated with the risk of fractures near the hip. Age and comorbidities increase the perioperative risk. Due to the ageing population, fracture of the proximal femur also proves to be a socio-economic problem. Preventive surgical measures have hardly been used so far. Methods 10 pairs of human femora from fresh cadavers were divided into control and low-volume femoroplasty groups and subjected to a Hayes fall-loading fracture test. The results of the respective localization and classification of the fracture site, the Singh index determined by computed tomography (CT) examination and the parameters in terms of fracture force, work to fracture and stiffness were evaluated statistically and with the finite element method. In addition, a finite element parametric study with different position angles and variants of the tubular geometry of the femoroplasty was performed. Findings Compared to the control group, the work to fracture could be increased by 33.2\%. The fracture force increased by 19.9\%. The used technique and instrumentation proved to be standardized and reproducible with an average poly(methyl methacrylate) volume of 10.5 ml. The parametric study showed the best results for the selected angle and geometry. Interpretation The cadaver studies demonstrated the biomechanical efficacy of the low-volume tubular femoroplasty. The numerical calculations confirmed the optimal choice of positioning as well as the inner and outer diameter of the tube in this setting. The standardized minimally invasive technique with the instruments developed for it could be used in further comparative studies to confirm the measured biomechanical results.}, language = {en} } @article{KramerValeroChansonetal.2019, author = {Kramer, Matthias and Valero, Daniel and Chanson, Hubert and Bung, Daniel Bernhard}, title = {Towards reliable turbulence estimations with phase-detection probes: an adaptive window cross-correlation technique}, series = {Experiments in Fluids}, volume = {60}, journal = {Experiments in Fluids}, publisher = {Springer}, address = {Berlin}, issn = {1432-1114}, doi = {10.1007/s00348-018-2650-9}, year = {2019}, language = {en} } @article{FerreinJacobsLakemeyer2005, author = {Ferrein, Alexander and Jacobs, Stefan and Lakemeyer, Gerhard}, title = {Controlling Unreal Tournament 2004 Bots with the logic-based action language Golog / Jacobs, Stefan ; Ferrein, Alexander ; Lakemeyer, Gerhard}, series = {Proceedings of the First AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment (AIIDE).}, journal = {Proceedings of the First AAAI Conference on Artificial Intelligence and Interactive Digital Entertainment (AIIDE).}, pages = {151 -- 152}, year = {2005}, language = {en} } @article{KueppersSteffenHellmuthetal.2014, author = {K{\"u}ppers, Tobias and Steffen, Victoria and Hellmuth, Hendrik and O'Connell, Timothy and Bongaerts, Johannes and Maurer, Karl-Heinz and Wiechert, Wolfgang}, title = {Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer}, series = {Microbial cell factories}, volume = {13}, journal = {Microbial cell factories}, publisher = {BioMed Central}, address = {London}, issn = {1475-2859 (E-Journal)}, doi = {10.1186/1475-2859-13-46}, pages = {Article No. 46}, year = {2014}, language = {en} } @article{KnoxBruggemannGossmannetal.2020, author = {Knox, Ronald and Bruggemann, Andrea and Gossmann, Matthias and Thomas, Ulrich and Horv{\´a}th, Andr{\´a}s and Dragicevic, Elena and Stoelzle-Feix, Sonja and Fertig, Niels and Jung, Alexander and Raman, Aravind Hariharan and Staat, Manfred and Linder, Peter}, title = {Combining physiological relevance and throughput for in vitro cardiac contractility measurement}, series = {Biophysical Journal}, volume = {118}, journal = {Biophysical Journal}, number = {Issue 3, Supplement 1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0006-3495}, doi = {10.1016/j.bpj.2019.11.3104}, pages = {570a}, year = {2020}, abstract = {Despite increasing acceptance of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) in safety pharmacology, controversy remains about the physiological relevance of existing in vitro models for their mechanical testing. We hypothesize that existing signs of immaturity of the cell models result from an improper mechanical environment. We cultured hiPSC-CMs in a 96-well format on hyperelastic silicone membranes imitating their native mechanical environment, resulting in physiological responses to compound stimuli.We validated cell responses on the FLEXcyte 96, with a set of reference compounds covering a broad range of cellular targets, including ion channel modulators, adrenergic receptor modulators and kinase inhibitors. Acute (10 - 30 min) and chronic (up to 7 days) effects were investigated. Furthermore, the measurements were complemented with electromechanical models based on electrophysiological recordings of the used cell types.hiPSC-CMs were cultured on freely-swinging, ultra-thin and hyperelastic silicone membranes. The weight of the cell culture medium deflects the membranes downwards. Rhythmic contraction of the hiPSC-CMs resulted in dynamic deflection changes which were quantified by capacitive distance sensing. The cells were cultured for 7 days prior to compound addition. Acute measurements were conducted 10-30 minutes after compound addition in standard culture medium. For chronic treatment, compound-containing medium was replaced daily for up to 7 days. Electrophysiological properties of the employed cell types were recorded by automated patch-clamp (Patchliner) and the results were integrated into the electromechanical model of the system.Calcium channel agonist S Bay K8644 and beta-adrenergic stimulator isoproterenol induced significant positive inotropic responses without additional external stimulation. Kinase inhibitors displayed cardiotoxic effects on a functional level at low concentrations. The system-integrated analysis detected alterations in beating shape as well as frequency and arrhythmic events and we provide a quantitative measure of these.}, language = {en} } @article{FerreinSteinbauer2016, author = {Ferrein, Alexander and Steinbauer, Gerald}, title = {Looking back on 20 Years of RoboCup}, series = {KI - K{\"u}nstliche Intelligenz}, volume = {30}, journal = {KI - K{\"u}nstliche Intelligenz}, number = {3-4}, publisher = {Springer}, address = {Berlin}, issn = {1610-1987}, doi = {10.1007/s13218-016-0443-y}, pages = {321 -- 323}, year = {2016}, language = {en} } @article{NguyenXuanRabczukNguyenThoietal.2011, author = {Nguyen-Xuan, H. and Rabczuk, T. and Nguyen-Thoi, T. and Tran, Thanh Ngoc and Nguyen-Thanh, N.}, title = {Computation of limit and shakedown loads using a node-based smoothed finite element method}, series = {International Journal for Numerical Methods in Engineering}, volume = {90}, journal = {International Journal for Numerical Methods in Engineering}, number = {3}, publisher = {Wiley}, address = {Weinheim}, issn = {1097-0207}, doi = {10.1002/nme.3317}, pages = {287 -- 310}, year = {2011}, abstract = {This paper presents a novel numerical procedure for computing limit and shakedown loads of structures using a node-based smoothed FEM in combination with a primal-dual algorithm. An associated primal-dual form based on the von Mises yield criterion is adopted. The primal-dual algorithm together with a Newton-like iteration are then used to solve this associated primal-dual form to determine simultaneously both approximate upper and quasi-lower bounds of the plastic collapse limit and the shakedown limit. The present formulation uses only linear approximations and its implementation into finite element programs is quite simple. Several numerical examples are given to show the reliability, accuracy, and generality of the present formulation compared with other available methods.}, language = {en} } @article{FerreinRensMeyeretal.2011, author = {Ferrein, Alexander and Rens, Gavin and Meyer, Thomas and Lakemeyer, Gerhard}, title = {A Logic for Specifying Partially Observable Stochastic Domains / Rens, Gavin ; Meyer, Thomas ; Ferrein, Alexander ; Lakemeyer, Gerhard}, series = {Proceedings of the Ninth International Workshop pn non-Monotonic Reasoning, Action and Change (NRAC`11)}, journal = {Proceedings of the Ninth International Workshop pn non-Monotonic Reasoning, Action and Change (NRAC`11)}, pages = {15 -- 22}, year = {2011}, language = {en} } @article{TranStaat2021, author = {Tran, Ngoc Trinh and Staat, Manfred}, title = {Direct plastic structural design under random strength and random load by chance constrained programming}, series = {European Journal of Mechanics - A/Solids}, volume = {85}, journal = {European Journal of Mechanics - A/Solids}, number = {Article 104106}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0997-7538}, doi = {10.1016/j.euromechsol.2020.104106}, year = {2021}, language = {en} } @article{HeuermannSchiek1994, author = {Heuermann, Holger and Schiek, Burkhard}, title = {Scattering Parameter Measurements of Microstrip Devices using the Double-LNN Calibration Technique}, series = {Conference proceedings : [Palais des Festivals et des Congr{\`e}s Cannes, France, 5 - 8 September 1994]}, journal = {Conference proceedings : [Palais des Festivals et des Congr{\`e}s Cannes, France, 5 - 8 September 1994]}, publisher = {Nexus Business Communications}, address = {Swanley}, isbn = {0-9518032-5-5}, year = {1994}, language = {en} } @article{SchwagerFleschSchwarzboezletal.2022, author = {Schwager, Christian and Flesch, Robert and Schwarzb{\"o}zl, Peter and Herrmann, Ulf and Teixeira Boura, Cristiano Jos{\´e}}, title = {Advanced two phase flow model for transient molten salt receiver system simulation}, series = {Solar Energy}, volume = {232}, journal = {Solar Energy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0038-092X (print)}, doi = {10.1016/j.solener.2021.12.065}, pages = {362 -- 375}, year = {2022}, abstract = {In order to realistically predict and optimize the actual performance of a concentrating solar power (CSP) plant sophisticated simulation models and methods are required. This paper presents a detailed dynamic simulation model for a Molten Salt Solar Tower (MST) system, which is capable of simulating transient operation including detailed startup and shutdown procedures including drainage and refill. For appropriate representation of the transient behavior of the receiver as well as replication of local bulk and surface temperatures a discretized receiver model based on a novel homogeneous two-phase (2P) flow modelling approach is implemented in Modelica Dymola®. This allows for reasonable representation of the very different hydraulic and thermal properties of molten salt versus air as well as the transition between both. This dynamic 2P receiver model is embedded in a comprehensive one-dimensional model of a commercial scale MST system and coupled with a transient receiver flux density distribution from raytracing based heliostat field simulation. This enables for detailed process prediction with reasonable computational effort, while providing data such as local salt film and wall temperatures, realistic control behavior as well as net performance of the overall system. Besides a model description, this paper presents some results of a validation as well as the simulation of a complete startup procedure. Finally, a study on numerical simulation performance and grid dependencies is presented and discussed.}, language = {en} } @article{YoshinobuMiyamotoWerneretal.2017, author = {Yoshinobu, Tatsuo and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species}, series = {Annual Review of Analytical Chemistry}, volume = {10}, journal = {Annual Review of Analytical Chemistry}, publisher = {Annual Reviews}, address = {Palo Alto, Calif.}, issn = {1936-1327}, doi = {10.1146/annurev-anchem-061516-045158}, pages = {225 -- 246}, year = {2017}, abstract = {A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.}, language = {en} } @article{BaeckerPouyeshmanSchnitzleretal.2011, author = {B{\"a}cker, Matthias and Pouyeshman, S. and Schnitzler, Thomas and Poghossian, Arshak and Wagner, Patrick and Biselli, Manfred and Sch{\"o}ning, Michael Josef}, title = {A silicon-based multi-sensor chip for monitoring of fermentation processes}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1364 -- 1369}, year = {2011}, language = {en} } @article{LehnertzMormannOsterhageetal.2007, author = {Lehnertz, Klaus and Mormann, Florian and Osterhage, Hannes and Andy, M{\"u}ller and Prusseit, Jens and Chernihovskyi, Anton and Staniek, Matth{\"a}us and Krug, Dieter and Bialonski, Stephan and Elger, Christian E.}, title = {State-of-the-art of seizure prediction}, series = {Journal of Clinical Neurophysiology}, volume = {24}, journal = {Journal of Clinical Neurophysiology}, number = {2}, issn = {1537-1603}, doi = {10.1097/WNP.0b013e3180336f16}, pages = {147 -- 153}, year = {2007}, language = {en} } @article{BhattaraiMayStaatetal.2022, author = {Bhattarai, Aroj and May, Charlotte Anabell and Staat, Manfred and Kowalczyk, Wojciech and Tran, Thanh Ngoc}, title = {Layer-specific damage modeling of porcine large intestine under biaxial tension}, series = {Bioengineering}, volume = {9}, journal = {Bioengineering}, number = {10, Early Access}, publisher = {MDPI}, address = {Basel}, issn = {2306-5354}, doi = {10.3390/bioengineering9100528}, pages = {1 -- 17}, year = {2022}, abstract = {The mechanical behavior of the large intestine beyond the ultimate stress has never been investigated. Stretching beyond the ultimate stress may drastically impair the tissue microstructure, which consequently weakens its healthy state functions of absorption, temporary storage, and transportation for defecation. Due to closely similar microstructure and function with humans, biaxial tensile experiments on the porcine large intestine have been performed in this study. In this paper, we report hyperelastic characterization of the large intestine based on experiments in 102 specimens. We also report the theoretical analysis of the experimental results, including an exponential damage evolution function. The fracture energies and the threshold stresses are set as damage material parameters for the longitudinal muscular, the circumferential muscular and the submucosal collagenous layers. A biaxial tensile simulation of a linear brick element has been performed to validate the applicability of the estimated material parameters. The model successfully simulates the biomechanical response of the large intestine under physiological and non-physiological loads.}, language = {en} } @article{WolfSchlickSpringer1997, author = {Wolf, Martin R. and Schlick, Christopher and Springer, J.}, title = {The use of implicit communication mechanisms in desktop-teleconferencing-systems}, series = {Proceedings of WWDU '97 Tokyo, Fifth International Scientific Conference on Work with Display Units : November 3 - 5, 1997, Tokyo}, journal = {Proceedings of WWDU '97 Tokyo, Fifth International Scientific Conference on Work with Display Units : November 3 - 5, 1997, Tokyo}, editor = {Miyamoto, Hiroyuki}, publisher = {-}, address = {Tokyo}, pages = {193 -- 194}, year = {1997}, language = {en} } @article{KnobeGiesenPlateetal.2016, author = {Knobe, M. and Giesen, M. and Plate, S. and Gradl-Dietsch, G. and Buecking, B. and Eschbach, D. and Laack, Walter van and Pape, H.-C.}, title = {The Aachen mobility and balance index to measure physiological falls risk: a comparison with the Tinetti POMA scale}, series = {European Journal Of Trauma And Emergency Surgery}, volume = {42}, journal = {European Journal Of Trauma And Emergency Surgery}, number = {5}, publisher = {Springer}, address = {Berlin}, issn = {1863-9941}, doi = {10.1007/s00068-016-0693-2}, pages = {537 -- 545}, year = {2016}, abstract = {Purpose The most commonly used mobility assessments for screening risk of falls among older adults are rating scales such as the Tinetti performance oriented mobility assessment (POMA). However, its correlation with falls is not always predictable and disadvantages of the scale include difficulty to assess many of the items on a 3-point scale and poor specificity. The purpose of this study was to describe the ability of the new Aachen Mobility and Balance Index (AMBI) to discriminate between subjects with a fall history and subjects without such events in comparison to the Tinetti POMA Scale. Methods For this prospective cohort study, 24 participants in the study group and 10 in the control group were selected from a population of patients in our hospital who had met the stringent inclusion criteria. Both groups completed the Tinetti POMA Scale (gait and balance component) and the AMBI (tandem stance, tandem walk, ten-meter-walk-test, sit-to-stand with five repetitions, 360° turns, timed-up-and-go-test and measurement of the dominant hand grip strength). A history of falls and hospitalization in the past year were evaluated retrospectively. The relationships among the mobility tests were examined with Bland-Altmananalysis. Receiver-operated characteristics curves, sensitivity and specificity were calculated. Results The study showed a strong negative correlation between the AMBI (17 points max., highest fall risk) and Tinetti POMA Scale (28 points max., lowest fall risk; r = -0.78, p < 0.001) with an excellent discrimination between community-dwelling older people and a younger control group. However, there were no differences in any of the mobility and balance measurements between participants with and without a fall history with equal characteristics in test comparison (AMBI vs. Tinetti POMA Scale: AUC 0.570 vs. 0.598; p = 0.762). The Tinetti POMA Scale (cut-off <20 points) showed a sensitivity of 0.45 and a specificity of 0.69, the AMBI a sensitivity of 0.64 and a specificity of 0.46 (cut-off >5 points). Conclusion The AMBI comprises mobility and balance tasks with increasing difficulty as well as a measurement of the dominant hand-grip strength. Its ability to identify fallers was comparable to the Tinetti POMA Scale. However, both measurement sets showed shortcomings in discrimination between fallers and non-fallers based on a self-reported retrospective falls-status.}, language = {en} } @article{AlKaidyKuthanHeringetal.2016, author = {Al-Kaidy, Huschyar and Kuthan, Kai and Hering, Thomas and Tippk{\"o}tter, Nils}, title = {Aqueous droplets used as enzymatic microreactors and their electromagnetic actuation}, series = {Journal of Visualized Experiments}, journal = {Journal of Visualized Experiments}, number = {Issue 126}, issn = {1940-087X}, doi = {10.3791/54643}, year = {2016}, abstract = {For the successful implementation of microfluidic reaction systems, such as PCR and electrophoresis, the movement of small liquid volumes is essential. In conventional lab-on-a-chip-platforms, solvents and samples are passed through defined microfluidic channels with complex flow control installations. The droplet actuation platform presented here is a promising alternative. With it, it is possible to move a liquid drop (microreactor) on a planar surface of a reaction platform (lab-in-a-drop). The actuation of microreactors on the hydrophobic surface of the platform is based on the use of magnetic forces acting on the outer shell of the liquid drops which is made of a thin layer of superhydrophobic magnetite particles. The hydrophobic surface of the platform is needed to avoid any contact between the liquid core and the surface to allow a smooth movement of the microreactor. On the platform, one or more microreactors with volumes of 10 µL can be positioned and moved simultaneously. The platform itself consists of a 3 x 3 matrix of electrical double coils which accommodate either neodymium or iron cores. The magnetic field gradients are automatically controlled. By variation of the magnetic field gradients, the microreactors' magnetic hydrophobic shell can be manipulated automatically to move the microreactor or open the shell reversibly. Reactions of substrates and corresponding enzymes can be initiated by merging the microreactors or bringing them into contact with surface immobilized catalysts.}, language = {en} } @article{AbouzarPoghossianPedrazaetal.2011, author = {Abouzar, Maryam H. and Poghossian, Arshak and Pedraza, A. M. and Gandhi, D. and Ingebrandt, S. and Moritz, W. and Sch{\"o}ning, Michael Josef}, title = {An array of field-effect nanoplate SOI capacitors for (bio-)chemical sensing}, series = {Biosensors and Bioelectronics. 26 (2011), H. 6}, journal = {Biosensors and Bioelectronics. 26 (2011), H. 6}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0956-5663}, pages = {3023 -- 3028}, year = {2011}, language = {en} }