@article{StaeudleSeynnesLapsetal.2021,
  author    = {St{\"a}udle, Benjamin and Seynnes, Olivier and Laps, Guido and G{\"o}ll, Fabian and Br{\"u}ggemann, Gert-Peter and Albracht, Kirsten},
  title     = {Recovery from achilles tendon repair: a combination of Postsurgery Outcomes and Insufficient remodeling of muscle and tendon},
  series = {Medicine \& Science in Sports \& Exercise},
  volume    = {53},
  journal   = {Medicine \& Science in Sports \& Exercise},
  number    = {7},
  publisher = {American College of Sports Medicine},
  address   = {Philadelphia, Pa.},
  issn      = {1530-0315},
  doi       = {10.1249/MSS.0000000000002592},
  pages     = {1356 -- 1366},
  year      = {2021},
  abstract  = {Achilles tendon rupture (ATR) patients have persistent functional deficits in the triceps surae muscle-tendon unit (MTU). The complex remodeling of the MTU accompanying these deficits remains poorly understood. The purpose of the present study was to associate in vivo and in silico data to investigate the relations between changes inMTU properties and strength deficits inATR patients. Methods: Elevenmale subjects who had undergone surgical repair of complete unilateral ATR were examined 4.6 ± 2.0 (mean ± SD) yr after rupture. Gastrocnemius medialis (GM) tendon stiffness, morphology, and muscle architecture were determined using ultrasonography. The force-length relation of the plantar flexor muscles was assessed at five ankle joint angles. In addition, simulations (OpenSim) of the GM MTU force-length properties were performed with various iterations of MTU properties found between the unaffected and the affected side. Results: The affected side of the patients displayed a longer, larger, and stiffer GM tendon (13\% ± 10\%, 105\% ± 28\%, and 54\% ± 24\%, respectively) compared with the unaffected side. The GM muscle fascicles of the affected side were shorter (32\% ± 12\%) and with greater pennation angles (31\% ± 26\%). A mean deficit in plantarflexion moment of 31\% ± 10\% was measured. Simulations indicate that pairing an intact muscle with a longer tendon shifts the optimal angular range of peak force outside physiological angular ranges, whereas the shorter muscle fascicles and tendon stiffening seen in the affected side decrease this shift, albeit incompletely. Conclusions: These results suggest that the substantial changes in MTU properties found in ATR patients may partly result from compensatory remodeling, although this process appears insufficient to fully restore muscle function.},
  language  = {en}
}
@article{WerkhausenAlbrachtCroninetal.2018,
  author    = {Werkhausen, Amelie and Albracht, Kirsten and Cronin, Neil J and Paulsen, G{\o}ran and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R},
  title     = {Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing},
  series = {Frontiers in physiology},
  journal   = {Frontiers in physiology},
  number    = {9},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2018.00794},
  pages     = {11 Seiten},
  year      = {2018},
  abstract  = {During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18\%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8\%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21\%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation.},
  language  = {en}
}
@article{YangKriechbaumerAlbrachtetal.2014,
  author    = {Yang, Peng-Fei and Kriechbaumer, Andreas and Albracht, Kirsten and Sanno, Maximilian and Ganse, Bergita and Koy, Timmo and Shang, Peng and br{\"u}ggemann, Gert-Peter and M{\"u}ller, Lars Peter and Rittweger, J{\"o}rn},
  title     = {A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans},
  series = {Journal of Orthopaedic Translation},
  volume    = {2},
  journal   = {Journal of Orthopaedic Translation},
  number    = {4},
  publisher = {Elsevier},
  address   = {Singapore},
  issn      = {2214-0328},
  doi       = {10.1016/j.jot.2014.07.078},
  pages     = {238 -- 238},
  year      = {2014},
  language  = {en}
}
@article{AngermannGuenthnerHanssenetal.2022,
  author    = {Angermann, Susanne and G{\"u}nthner, Roman and Hanssen, Henner and Lorenz, Georg and Braunisch, Matthias C. and Steubl, Dominik and Matschkal, Julia and Kemmner, Stephan and Hausinger, Renate and Block, Zenonas and Haller, Bernhard and Heemann, Uwe and Kotliar, Konstantin and Grimmer, Timo and Schmaderer, Christoph},
  title     = {Cognitive impairment and microvascular function in end-stage renal disease},
  series = {International Journal of Methods in Psychiatric Research (MPR)},
  volume    = {31},
  journal   = {International Journal of Methods in Psychiatric Research (MPR)},
  number    = {2},
  publisher = {Wiley},
  issn      = {1049-8931 (Print)},
  doi       = {10.1002/mpr.1909},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.},
  language  = {en}
}
@article{KotliarOrtnerConradietal.2022,
  author    = {Kotliar, Konstantin and Ortner, Marion and Conradi, Anna and Hacker, Patricia and Hauser, Christine and G{\"u}nthner, Roman and Moser, Michaela and Muggenthaler, Claudia and Diehl-Schmid, Janine and Priller, Josef and Schmaderer, Christoph and Grimmer, Timo},
  title     = {Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance},
  series = {Neurobiology of Aging},
  volume    = {120},
  journal   = {Neurobiology of Aging},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0197-4580},
  doi       = {10.1016/j.neurobiolaging.2022.08.012},
  pages     = {117 -- 127},
  year      = {2022},
  abstract  = {Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis.},
  language  = {en}
}
@article{NeumaierWeissVeldemanetal.2021,
  author    = {Neumaier, Felix and Weiss, Miriam and Veldeman, Michael and Kotliar, Konstantin and Wiesmann, Martin and Schulze-Steinen, Henna and H{\"o}llig, Anke and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid},
  title     = {Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage - preliminary findings from an observational cohort study},
  series = {Clinical Neurology and Neurosurgery},
  volume    = {208},
  journal   = {Clinical Neurology and Neurosurgery},
  number    = {Article No.: 106870},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0303-8467},
  doi       = {10.1016/j.clineuro.2021.106870},
  year      = {2021},
  abstract  = {Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.},
  language  = {en}
}
@article{AlnemerKotliarNeuhausetal.2023,
  author    = {Alnemer, Momin Sami Mohammad and Kotliar, Konstantin and Neuhaus, Valentin and Pape, Hans-Christoph and Ciritsis, Bernhard D.},
  title     = {Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model},
  series = {Cost Effectiveness and Resource Allocation},
  journal   = {Cost Effectiveness and Resource Allocation},
  number    = {21, Article number: 77},
  publisher = {Springer Nature},
  issn      = {1478-7547},
  doi       = {10.1186/s12962-023-00482-4},
  pages     = {12 Seiten},
  year      = {2023},
  abstract  = {Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare \& Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10\% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10\% fracture risk reduction, model A costs between \$8,850 and \$46,940 per quality-adjusted life-year (\$/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8\% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side's prophylaxis, the patient's age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between \$11,000/QALY and \$74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.},
  language  = {en}
}
@article{KuchlerGuenthnerRibeiroetal.2023,
  author    = {Kuchler, Timon and G{\"u}nthner, Roman and Ribeiro, Andrea and Hausinger, Renate and Streese, Lukas and W{\"o}hnl, Anna and Kesseler, Veronika and Negele, Johanna and Assali, Tarek and Carbajo-Lozoya, Javier and Lech, Maciej and Adorjan, Kristina and Stubbe, Hans Christian and Hanssen, Henner and Kotliar, Konstantin and Haller, Berhard and Heemann, Uwe and Schmaderer, Christoph},
  title     = {Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation},
  volume    = {26},
  publisher = {Springer Nature},
  address   = {Dordrecht},
  doi       = {10.1007/s10456-023-09885-6},
  pages     = {547 -- 563},
  year      = {2023},
  abstract  = {Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42\% ± 1.77\% vs. 4.64\% ± 2.59\%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5-190.2] vs. 189.1 [179.4-197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8-0.9] vs. 0.88 [0.8-0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = - 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.},
  language  = {en}
}
@article{KuertenKotliarFuestetal.2021,
  author    = {Kuerten, David and Kotliar, Konstantin and Fuest, Matthias and Walter, Peter and Hollstein, Muriel and Plange, Niklas},
  title     = {Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study},
  series = {International Ophthalmology},
  volume    = {41},
  journal   = {International Ophthalmology},
  number    = {41},
  editor    = {Neri, Piergiorgio},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {1573-2630},
  doi       = {10.1007/s10792-021-01876-0},
  pages     = {3109 -- 3119},
  year      = {2021},
  abstract  = {Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.},
  language  = {en}
}
@article{AlbannaConzenWeissetal.2021,
  author    = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander},
  title     = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis},
  series = {Frontiers in Neurology},
  volume    = {12},
  journal   = {Frontiers in Neurology},
  number    = {12},
  issn      = {1664-2295},
  doi       = {10.3389/fneur.2021.690183},
  pages     = {1 -- 15},
  year      = {2021},
  abstract  = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.},
  language  = {en}
}
@article{WerfelGuenthnerHapfelmeieretal.2022,
  author    = {Werfel, Stanislas and G{\"u}nthner, Roman and Hapfelmeier, Alexander and Hanssen, Henner and Kotliar, Konstantin and Heemann, Uwe and Schmaderer, Christoph},
  title     = {Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning},
  series = {Cardiovascular Research},
  volume    = {118},
  journal   = {Cardiovascular Research},
  number    = {2},
  editor    = {Guzik, Tomasz J.},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {0008-6363},
  doi       = {10.1093/cvr/cvab040},
  pages     = {612 -- 621},
  year      = {2022},
  abstract  = {Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.},
  language  = {en}
}
@article{MalanHamerKaeneletal.2020,
  author    = {Malan, Leone and Hamer, Mark and K{\"a}nel, Roland von and Kotliar, Konstantin and Wyk, Roelof D. van and Lambert, Gavin W. and Vilser, Walthard and Ziemssen, Tjalf and Schlaich, Markus P. and Smith, Wayne and Magnusson, Martin and Wentzel, Annemarie and Myburgh, Carlien E. and Steyn, Hendrik S. and Malan, Nico T.},
  title     = {Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study},
  series = {Cardiovascular Journal of Africa},
  volume    = {26},
  journal   = {Cardiovascular Journal of Africa},
  number    = {31},
  publisher = {Clinics Cardive Publishing},
  address   = {Durbanville},
  issn      = {1680-0745},
  doi       = {10.5830/CVJA-2020-031},
  pages     = {1 -- 12},
  year      = {2020},
  language  = {en}
}
@article{StreeseKotliarDeiserothetal.2020,
  author    = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner},
  title     = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial},
  series = {Scandinavian Journal of Medicine and Science in Sports},
  volume    = {30},
  journal   = {Scandinavian Journal of Medicine and Science in Sports},
  number    = {2},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {1600-0838},
  doi       = {10.1111/sms.13560},
  pages     = {272 -- 280},
  year      = {2020},
  abstract  = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.},
  language  = {en}
}
@article{HamouKotliarTanetal.2020,
  author    = {Hamou, Hussam Aldin and Kotliar, Konstantin and Tan, Sonny Kian and Weiß, Christel and Blume, Christian and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid},
  title     = {Surgical nuances and placement of subgaleal drains for supratentorial procedures—a prospective analysis of efficacy and outcome in 150 craniotomies},
  series = {Acta Neurochirurgica},
  volume    = {2020},
  journal   = {Acta Neurochirurgica},
  number    = {162},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {0942-0940},
  doi       = {10.1007/s00701-019-04196-6},
  pages     = {729 -- 736},
  year      = {2020},
  abstract  = {Background For supratentorial craniotomy, surgical access, and closure technique, including placement of subgaleal drains, may vary considerably. The influence of surgical nuances on postoperative complications such as cerebrospinal fluid leakage or impaired wound healing overall remains largely unclear. With this study, we are reporting our experiences and the impact of our clinical routines on outcome in a prospectively collected data set. Method We prospectively observed 150 consecutive patients undergoing supratentorial craniotomy and recorded technical variables (type/length of incision, size of craniotomy, technique of dural and skin closure, type of dressing, and placement of subgaleal drains). Outcome variables (subgaleal hematoma/CSF collection, periorbital edema, impairment of wound healing, infection, and need for operative revision) were recorded at time of discharge and at late follow-up. Results Early subgaleal fluid collection was observed in 36.7\% (2.8\% at the late follow-up), and impaired wound healing was recorded in 3.3\% of all cases, with an overall need for operative revision of 6.7\%. Neither usage of dural sealants, lack of watertight dural closure, and presence of subgaleal drains, nor type of skin closure or dressing influenced outcome. Curved incisions, larger craniotomy, and tumor size, however, were associated with an increase in early CSF or hematoma collection (p < 0.0001, p = 0.001, p < 0.01 resp.), and larger craniotomy size was associated with longer persistence of subgaleal fluid collections (p < 0.05). Conclusions Based on our setting, individual surgical nuances such as the type of dural closure and the use of subgaleal drains resulted in a comparable complication rate and outcome. Subgaleal fluid collections were frequently observed after supratentorial procedures, irrespective of the closing technique employed, and resolve spontaneously in the majority of cases without significant sequelae. Our results are limited due to the observational nature in our single-center study and need to be validated by supportive prospective randomized design.},
  language  = {en}
}
@article{RamoshabaHuismanLammertynetal.2020,
  author    = {Ramoshaba, Nthai E. and Huisman, Hugo W. and Lammertyn, Leandi and Kotliar, Konstantin and Schutte, Aletta E. and Smith, Wayne},
  title     = {Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study},
  series = {Hypertension Research},
  journal   = {Hypertension Research},
  number    = {43},
  publisher = {Springer Nature},
  address   = {Osaka},
  issn      = {1348-4214},
  doi       = {10.1038/s41440-020-0487-0},
  pages     = {1231 -- 1238},
  year      = {2020},
  abstract  = {Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20-30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = -0.097 (95\% CI = -0.165; -0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95\% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.},
  language  = {en}
}
@article{SmithKotliarLammertynetal.2020,
  author    = {Smith, Wayne and Kotliar, Konstantin and Lammertyn, Leandi and Ramoshaba, Nthai E. and Vilser, Walthard and Huisman, Hugo W. and Schutte, Aletta E.},
  title     = {Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study},
  series = {Microvascular Research},
  volume    = {128},
  journal   = {Microvascular Research},
  number    = {Article 103937},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0026-2862},
  doi       = {10.1016/j.mvr.2019.103937},
  year      = {2020},
  abstract  = {Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults. Methods We included 112 black and 143 white healthy normotensive adults (20-30 years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected. Results The groups displayed similar 24 h BP profiles and anthropometry (all p > .24). Black participants demonstrated a smaller CRAE (158 ± 11 vs. 164 ± 11 MU, p < .001) compared to the white group, whereas CRVE was similar (p = .57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6 ± 2.1 vs. 3.3 ± 1.8\%; p < .001). Conclusions Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation.},
  language  = {en}
}
@article{NeumaierKotliarHaerenetal.2021,
  author    = {Neumaier, Felix and Kotliar, Konstantin and Haeren, Roel Hubert Louis and Temel, Yasin and L{\"u}ke, Jan Niklas and Seyam, Osama and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Schubert, Gerrit Alexander and Schneider, Toni and Albanna, Walid},
  title     = {Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA)},
  series = {Frontiers in Neurology},
  volume    = {12},
  journal   = {Frontiers in Neurology},
  publisher = {Frontiers},
  doi       = {10.3389/fneur.2021.659890},
  pages     = {1 -- 11},
  year      = {2021},
  language  = {en}
}
@article{DegeringEggertPulsetal.2010,
  author    = {Degering, Christian and Eggert, Thorsten and Puls, Michael and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and Jaeger, Karl-Erich},
  title     = {Optimization of protease secretion in Bacillus subtilis and Bacillus licheniformis by screening of homologous and herologous signal peptides},
  series = {Applied and environmental microbiology},
  volume    = {76},
  journal   = {Applied and environmental microbiology},
  number    = {19},
  publisher = {American Society for Microbiology},
  address   = {Washington, DC},
  issn      = {1098-5336 (E-Journal); 0003-6919 (Print); 0099-2240 (Print)},
  doi       = {10.1128/AEM.01146-10},
  pages     = {6370 -- 6378},
  year      = {2010},
  abstract  = {Bacillus subtilis and Bacillus licheniformis are widely used for the large-scale industrial production of proteins. These strains can efficiently secrete proteins into the culture medium using the general secretion (Sec) pathway. A characteristic feature of all secreted proteins is their N-terminal signal peptides, which are recognized by the secretion machinery. Here, we have studied the production of an industrially important secreted protease, namely, subtilisin BPN′ from Bacillus amyloliquefaciens. One hundred seventy-three signal peptides originating from B. subtilis and 220 signal peptides from the B. licheniformis type strain were fused to this secretion target and expressed in B. subtilis, and the resulting library was analyzed by high-throughput screening for extracellular proteolytic activity. We have identified a number of signal peptides originating from both organisms which produced significantly increased yield of the secreted protease. Interestingly, we observed that levels of extracellular protease were improved not only in B. subtilis, which was used as the screening host, but also in two different B. licheniformis strains. To date, it is impossible to predict which signal peptide will result in better secretion and thus an improved yield of a given extracellular target protein. Our data show that screening a library consisting of homologous and heterologous signal peptides fused to a target protein can identify more-effective signal peptides, resulting in improved protein export not only in the original screening host but also in different production strains.},
  language  = {en}
}
@article{DeppeBongaertsO'Connelletal.2011,
  author    = {Deppe, Veronika Maria and Bongaerts, Johannes and O'Connell, Timothy and Maurer, Karl-Heinz and Meinhardt, Friedhelm},
  title     = {Enzymatic deglycation of Amadori products in bacteria},
  series = {Applied microbiology and biotechnology},
  volume    = {Vol. 90},
  journal   = {Applied microbiology and biotechnology},
  number    = {Iss. 2},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)},
  pages     = {399 -- 406},
  year      = {2011},
  language  = {en}
}
@article{AlexopoulosHoffschmidt2017,
  author    = {Alexopoulos, Spiros and Hoffschmidt, Bernhard},
  title     = {Advances in solar tower technology},
  series = {Wiley interdisciplinary reviews : Energy and Environment : WIREs},
  volume    = {6},
  journal   = {Wiley interdisciplinary reviews : Energy and Environment : WIREs},
  number    = {1},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {2041-840X},
  doi       = {10.1002/wene.217},
  pages     = {1 -- 19},
  year      = {2017},
  language  = {en}
}
@article{FunkeBeckmannKeinzetal.2018,
  author    = {Funke, Harald and Beckmann, Nils and Keinz, Jan and Abanteriba, Sylvester},
  title     = {Comparison of Numerical Combustion Models for Hydrogen and Hydrogen-Rich Syngas Applied for Dry-Low-Nox-Micromix-Combustion},
  series = {Journal of Engineering for Gas Turbines and Power},
  volume    = {140},
  journal   = {Journal of Engineering for Gas Turbines and Power},
  number    = {8},
  publisher = {ASME},
  address   = {New York, NY},
  issn      = {0742-4795},
  doi       = {10.1115/1.4038882},
  pages     = {9 Seiten},
  year      = {2018},
  abstract  = {The Dry-Low-NOx (DLN) Micromix combustion technology has been developed as low emission combustion principle for industrial gas turbines fueled with hydrogen or syngas. The combustion process is based on the phenomenon of jet-in-crossflow-mixing (JICF). Fuel is injected perpendicular into the air-cross-flow and burned in a multitude of miniaturized, diffusion-like flames. The miniaturization of the flames leads to a significant reduction of NOx emissions due to the very short residence time of reactants in the flame. In the Micromix research approach, computational fluid dynamics (CFD) analyses are validated toward experimental results. The combination of numerical and experimental methods allows an efficient design and optimization of DLN Micromix combustors concerning combustion stability and low NOx emissions. The paper presents a comparison of several numerical combustion models for hydrogen and hydrogen-rich syngas. They differ in the complexity of the underlying reaction mechanism and the associated computational effort. The performance of a hybrid eddy-break-up (EBU) model with a one-step global reaction is compared to a complex chemistry model and a flamelet generated manifolds (FGM) model, both using detailed reaction schemes for hydrogen or syngas combustion. Validation of numerical results is based on exhaust gas compositions available from experimental investigation on DLN Micromix combustors. The conducted evaluation confirms that the applied detailed combustion mechanisms are able to predict the general physics of the DLN-Micromix combustion process accurately. The FGM method proved to be generally suitable to reduce the computational effort while maintaining the accuracy of detailed chemistry.},
  language  = {en}
}
@article{GoettenHavermannBraunetal.2020,
  author    = {G{\"o}tten, Falk and Havermann, Marc and Braun, Carsten and Marino, Matthew and Bil, Cees},
  title     = {Improved Form Factor for Drag Estimation of Fuselages with Various Cross Sections},
  series = {Journal of Aircraft},
  journal   = {Journal of Aircraft},
  publisher = {AIAA},
  address   = {Reston, Va.},
  issn      = {1533-3868},
  doi       = {10.2514/1.C036032},
  pages     = {1 -- 13},
  year      = {2020},
  abstract  = {The paper presents an aerodynamic investigation of 70 different streamlined bodies with fineness ratios ranging from 2 to 10. The bodies are chosen to idealize both unmanned and small manned aircraft fuselages and feature cross-sectional shapes that vary from circular to quadratic. The study focuses on friction and pressure drag in dependency of the individual body's fineness ratio and cross section. The drag forces are normalized with the respective body's wetted area to comply with an empirical drag estimation procedure. Although the friction drag coefficient then stays rather constant for all bodies, their pressure drag coefficients decrease with an increase in fineness ratio. Referring the pressure drag coefficient to the bodies' cross-sectional areas shows a distinct pressure drag minimum at a fineness ratio of about three. The pressure drag of bodies with a quadratic cross section is generally higher than for bodies of revolution. The results are used to derive an improved form factor that can be employed in a classic empirical drag estimation method. The improved formulation takes both the fineness ratio and cross-sectional shape into account. It shows superior accuracy in estimating streamlined body drag when compared with experimental data and other form factor formulations of the literature.},
  language  = {en}
}
@article{MuschallikMolinnusBongaertsetal.2017,
  author    = {Muschallik, Lukas and Molinnus, Denise and Bongaerts, Johannes and Pohl, Martina and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Siegert, Petra and Selmer, Thorsten},
  title     = {(R,R)-Butane-2,3-diol Dehydrogenase from Bacillus clausii DSM 8716T: Cloning and Expression of the bdhA-Gene, and Initial Characterization of Enzyme},
  series = {Journal of Biotechnology},
  volume    = {258},
  journal   = {Journal of Biotechnology},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0168-1656},
  doi       = {10.1016/j.jbiotec.2017.07.020},
  pages     = {41 -- 50},
  year      = {2017},
  abstract  = {The gene encoding a putative (R,R)-butane-2,3-diol dehydrogenase (bdhA) from Bacillus clausii DSM 8716T was isolated, sequenced and expressed in Escherichia coli. The amino acid sequence of the encoded protein is only distantly related to previously studied enzymes (identity 33-43\%) and exhibited some uncharted peculiarities. An N-terminally StrepII-tagged enzyme variant was purified and initially characterized. The isolated enzyme catalyzed the (R)-specific oxidation of (R,R)- and meso-butane-2,3-diol to (R)- and (S)-acetoin with specific activities of 12 U/mg and 23 U/mg, respectively. Likewise, racemic acetoin was reduced with a specific activity of up to 115 U/mg yielding a mixture of (R,R)- and meso-butane-2,3-diol, while the enzyme reduced butane-2,3-dione (Vmax 74 U/mg) solely to (R,R)-butane-2,3-diol via (R)-acetoin. For these reactions only activity with the co-substrates NADH/NAD+ was observed. The enzyme accepted a selection of vicinal diketones, α-hydroxy ketones and vicinal diols as alternative substrates. Although the physiological function of the enzyme in B. clausii remains elusive, the data presented herein clearly demonstrates that the encoded enzyme is a genuine (R,R)-butane-2,3-diol dehydrogenase with potential for applications in biocatalysis and sensor development.},
  language  = {en}
}
@article{JossekBongaertsSprenger2001,
  author    = {Jossek, Ralf and Bongaerts, Johannes and Sprenger, Georg A.},
  title     = {Characterization of a new feedback-resistant 3-deoxy-D-arabinoheptulosonate 7-phosphate synthase AroF of Escherichia coli},
  series = {FEMS microbiology letters},
  volume    = {Vol. 202},
  journal   = {FEMS microbiology letters},
  number    = {Iss. 1},
  issn      = {1574-6968},
  pages     = {145 -- 148},
  year      = {2001},
  language  = {en}
}
@article{GeierLehnertzBialonski2015,
  author    = {Geier, Christian and Lehnertz, Klaus and Bialonski, Stephan},
  title     = {Time-dependent degree-degree correlations in epileptic brain networks: from assortative to dissortative mixing},
  series = {Frontiers in Human Neuroscience},
  journal   = {Frontiers in Human Neuroscience},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1662-5161},
  doi       = {10.3389/fnhum.2015.00462},
  year      = {2015},
  language  = {en}
}
@article{LaarmannThomaMischetal.2023,
  author    = {Laarmann, Lukas and Thoma, Andreas and Misch, Philipp and R{\"o}th, Thilo and Braun, Carsten and Watkins, Simon and Fard, Mohammad},
  title     = {Automotive safety approach for future eVTOL vehicles},
  series = {CEAS Aeronautical Journal},
  journal   = {CEAS Aeronautical Journal},
  publisher = {Springer Nature},
  issn      = {1869-5590 (Online)},
  doi       = {10.1007/s13272-023-00655-0},
  pages     = {11 Seiten},
  year      = {2023},
  abstract  = {The eVTOL industry is a rapidly growing mass market expected to start in 2024. eVTOL compete, caused by their predicted missions, with ground-based transportation modes, including mainly passenger cars. Therefore, the automotive and classical aircraft design process is reviewed and compared to highlight advantages for eVTOL development. A special focus is on ergonomic comfort and safety. The need for further investigation of eVTOL's crashworthiness is outlined by, first, specifying the relevance of passive safety via accident statistics and customer perception analysis; second, comparing the current state of regulation and certification; and third, discussing the advantages of integral safety and applying the automotive safety approach for eVTOL development. Integral safety links active and passive safety, while the automotive safety approach means implementing standardized mandatory full-vehicle crash tests for future eVTOL. Subsequently, possible crash impact conditions are analyzed, and three full-vehicle crash load cases are presented.},
  language  = {en}
}
@article{WilmingBegemannKuhneetal.2013,
  author    = {Wilming, Anja and Begemann, Jens and Kuhne, Stefan and Regestein, Lars and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and B{\"u}chs, Jochen},
  title     = {Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations},
  series = {Biochemical engineering journal},
  volume    = {Vol. 73},
  journal   = {Biochemical engineering journal},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-295X (E-Journal); 1369-703X (Print)},
  pages     = {29 -- 37},
  year      = {2013},
  language  = {en}
}
@article{Alexopoulos2015,
  author    = {Alexopoulos, Spiros},
  title     = {Simulation model for the transient process behaviour of solar aluminium recycling in a rotary kiln},
  series = {Applied Thermal Engineering},
  volume    = {78},
  journal   = {Applied Thermal Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1359-4311},
  doi       = {10.1016/j.applthermaleng.2015.01.007},
  pages     = {387 -- 396},
  year      = {2015},
  language  = {en}
}
@article{BoehnischBraunMuscarelloetal.2024,
  author    = {B{\"o}hnisch, Nils and Braun, Carsten and Muscarello, Vincenzo and Marzocca, Pier},
  title     = {About the wing and whirl flutter of a slender wing-propeller system},
  series = {Journal of Aircraft},
  journal   = {Journal of Aircraft},
  publisher = {AIAA},
  address   = {Reston, Va.},
  issn      = {1533-3868},
  doi       = {10.2514/1.C037542},
  pages     = {1 -- 14},
  year      = {2024},
  abstract  = {Next-generation aircraft designs often incorporate multiple large propellers attached along the wingspan (distributed electric propulsion), leading to highly flexible dynamic systems that can exhibit aeroelastic instabilities. This paper introduces a validated methodology to investigate the aeroelastic instabilities of wing-propeller systems and to understand the dynamic mechanism leading to wing and whirl flutter and transition from one to the other. Factors such as nacelle positions along the wing span and chord and its propulsion system mounting stiffness are considered. Additionally, preliminary design guidelines are proposed for flutter-free wing-propeller systems applicable to novel aircraft designs. The study demonstrates how the critical speed of the wing-propeller systems is influenced by the mounting stiffness and propeller position. Weak mounting stiffnesses result in whirl flutter, while hard mounting stiffnesses lead to wing flutter. For the latter, the position of the propeller along the wing span may change the wing mode shapes and thus the flutter mechanism. Propeller positions closer to the wing tip enhance stability, but pusher configurations are more critical due to the mass distribution behind the elastic axis.},
  language  = {en}
}
@article{UlmerBraunChengetal.2023,
  author    = {Ulmer, Jessica and Braun, Sebastian and Cheng, Chi-Tsun and Dowey, Steve and Wollert, J{\"o}rg},
  title     = {A human factors-aware assistance system in manufacturing based on gamification and hardware modularisation},
  series = {International Journal of Production Research},
  journal   = {International Journal of Production Research},
  publisher = {Taylor \& Francis},
  issn      = {0020-7543 (Print)},
  doi       = {10.1080/00207543.2023.2166140},
  year      = {2023},
  abstract  = {Assistance systems have been widely adopted in the manufacturing sector to facilitate various processes and tasks in production environments. However, existing systems are mostly equipped with rigid functional logic and do not provide individual user experiences or adapt to their capabilities. This work integrates human factors in assistance systems by adjusting the hardware and instruction presented to the workers' cognitive and physical demands. A modular system architecture is designed accordingly, which allows a flexible component exchange according to the user and the work task. Gamification, the use of game elements in non-gaming contexts, has been further adopted in this work to provide level-based instructions and personalised feedback. The developed framework is validated by applying it to a manual workstation for industrial assembly routines.},
  language  = {en}
}
@article{FiedlerOrzadaFloeseretal.2021,
  author    = {Fiedler, Thomas M. and Orzada, Stephan and Fl{\"o}ser, Martina and Rietsch, Stefan H. G. and Quick, Harald H. and Ladd, Mark E. and Bitz, Andreas},
  title     = {Performance analysis of integrated RF microstrip transmit antenna arrays with high channel count for body imaging at 7 T},
  series = {NMR in Biomedicine},
  volume    = {34},
  journal   = {NMR in Biomedicine},
  number    = {7},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {0952-3480 (ISSN)},
  doi       = {10.1002/nbm.4515},
  pages     = {18 SeitenWiley},
  year      = {2021},
  abstract  = {The aim of the current study was to investigate the performance of integrated RF transmit arrays with high channel count consisting of meander microstrip antennas for body imaging at 7 T and to optimize the position and number of transmit ele- ments. RF simulations using multiring antenna arrays placed behind the bore liner were performed for realistic exposure conditions for body imaging. Simulations were performed for arrays with as few as eight elements and for arrays with high channel counts of up to 48 elements. The B1+ field was evaluated regarding the degrees of freedom for RF shimming in the abdomen. Worst-case specific absorption rate (SARwc ), SAR overestimation in the matrix compression, the number of virtual obser- vation points (VOPs) and SAR efficiency were evaluated. Constrained RF shimming was performed in differently oriented regions of interest in the body, and the devia- tion from a target B1+ field was evaluated. Results show that integrated multiring arrays are able to generate homogeneous B1+ field distributions for large FOVs, espe- cially for coronal/sagittal slices, and thus enable body imaging at 7 T with a clinical workflow; however, a low duty cycle or a high SAR is required to achieve homoge- neous B1+ distributions and to exploit the full potential. In conclusion, integrated arrays allow for high element counts that have high degrees of freedom for the pulse optimization but also produce high SARwc , which reduces the SAR accuracy in the VOP compression for low-SAR protocols, leading to a potential reduction in array performance. Smaller SAR overestimations can increase SAR accuracy, but lead to a high number of VOPs, which increases the computational cost for VOP evaluation and makes online SAR monitoring or pulse optimization challenging. Arrays with interleaved rings showed the best results in the study.},
  language  = {en}
}
@article{ChwallekNawrathKrastinaetal.2024,
  author    = {Chwallek, Constanze and Nawrath, Lara and Krastina, Anzelika and Bruksle, Ieva},
  title     = {Supportive research on sustainable entrepreneurship and business practices},
  series = {SECA Sustainable Entrepreneurship for Climate Action},
  journal   = {SECA Sustainable Entrepreneurship for Climate Action},
  number    = {3},
  publisher = {Lapland University of Applied Sciences Ltd},
  address   = {Rovaniemi},
  isbn      = {978-952-316-514-4 (pdf)},
  issn      = {2954-1654 (on-line publication)},
  pages     = {67 Seiten},
  year      = {2024},
  language  = {en}
}
@article{WildSchrezenmeierCzupallaetal.2020,
  author    = {Wild, Dominik and Schrezenmeier, Johannes and Czupalla, Markus and F{\"o}rstner, Roger},
  title     = {Thermal Characterization of additive manufactured Integral Structures for Phase Change Applications},
  series = {2020 International Conference on Environmental Systems},
  journal   = {2020 International Conference on Environmental Systems},
  publisher = {Texas Tech University},
  year      = {2020},
  abstract  = {"Infused Thermal Solutions" (ITS) introduces a method for passive thermal control to stabilize structural components thermally without active heating and cooling systems, by using phase change material (PCM) in combination with lattice - both embedded into an additive manufactured integral structure. The technology is currently under development. This paper presents the results of the thermal property measurements performed on additive manufactured ITS breadboards. Within the breadboard campaigns key characteristics of the additive manufactured specimens were derived: Mechanical parameters: specimen impermeability, minimum wall thickness, lattice structure, subsequent heat treatment. Thermal properties: thermo-optical surface properties of the additive manufactured raw material, thermal conductivity and specific heat capacity measurements. As a conclusion the paper introduces an overview of potential ITS hardware applications, expected to increase the thermal performance.},
  language  = {en}
}
@article{SchopenNarayanBeckmannetal.2024,
  author    = {Schopen, Oliver and Narayan, Sriram and Beckmann, Marvin and Najmi, Aezid-Ul-Hassan and Esch, Thomas and Shabani, Bahman},
  title     = {An EIS approach to quantify the effects of inlet air relative humidity on the performance of proton exchange membrane fuel cells: a pathway to developing a novel fault diagnostic method},
  series = {International Journal of Hydrogen Energy},
  volume    = {58},
  journal   = {International Journal of Hydrogen Energy},
  number    = {8},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0360-3199 (print)},
  issn      = {1879-3487 (online)},
  doi       = {10.1016/j.ijhydene.2024.01.218},
  pages     = {1302 -- 1315},
  year      = {2024},
  abstract  = {In this work, the effect of low air relative humidity on the operation of a polymer electrolyte membrane fuel cell is investigated. An innovative method through performing in situ electrochemical impedance spectroscopy is utilised to quantify the effect of inlet air relative humidity at the cathode side on internal ionic resistances and output voltage of the fuel cell. In addition, algorithms are developed to analyse the electrochemical characteristics of the fuel cell. For the specific fuel cell stack used in this study, the membrane resistance drops by over 39 \% and the cathode side charge transfer resistance decreases by 23 \% after increasing the humidity from 30 \% to 85 \%, while the results of static operation also show an increase of ∼2.2 \% in the voltage output after increasing the relative humidity from 30 \% to 85 \%. In dynamic operation, visible drying effects occur at < 50 \% relative humidity, whereby the increase of the air side stoichiometry increases the drying effects. Furthermore, other parameters, such as hydrogen humidification, internal stack structure, and operating parameters like stoichiometry, pressure, and temperature affect the overall water balance. Therefore, the optimal humidification range must be determined by considering all these parameters to maximise the fuel cell performance and durability. The results of this study are used to develop a health management system to ensure sufficient humidification by continuously monitoring the fuel cell polarisation data and electrochemical impedance spectroscopy indicators.},
  language  = {en}
}
@article{UysalCreutzFiratetal.2022,
  author    = {Uysal, Karya and Creutz, Till and Firat, Ipek Seda and Artmann, Gerhard and Teusch, Nicole and Temiz Artmann, Ayseg{\"u}l},
  title     = {Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments},
  series = {Polymers},
  volume    = {14},
  journal   = {Polymers},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2073-4360},
  pages     = {2213},
  year      = {2022},
  abstract  = {Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3-4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications.},
  language  = {en}
}
@article{TemizArtmannKurulgandemirciFıratetal.2021,
  author    = {Temiz Artmann, Ayseg{\"u}l and Kurulgan demirci, Eylem and F{\i}rat, Ipek Seda and Oflaz, Hakan and Artmann, Gerhard},
  title     = {Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers},
  series = {SHOCK},
  journal   = {SHOCK},
  publisher = {Wolters Kluwer},
  address   = {K{\"o}ln},
  issn      = {1540-0514},
  doi       = {10.1097/SHK.0000000000001845},
  year      = {2021},
  language  = {en}
}
@article{KowalewskiBragardHueningetal.2023,
  author    = {Kowalewski, Paul and Bragard, Michael and H{\"u}ning, Felix and De Doncker, Rik W.},
  title     = {An inexpensive Wiegand-sensor-based rotary encoder without rotating magnets for use in electrical drives},
  series = {IEEE Transactions on Instrumentation and Measurement},
  volume    = {72},
  journal   = {IEEE Transactions on Instrumentation and Measurement},
  publisher = {IEEE},
  address   = {New York},
  issn      = {0018-9456 (Print)},
  doi       = {10.1109/TIM.2023.3326166},
  pages     = {10 Seiten},
  year      = {2023},
  abstract  = {This paper introduces an inexpensive Wiegand-sensor-based rotary encoder that avoids rotating magnets and is suitable for electrical-drive applications. So far, Wiegand-sensor-based encoders usually include a magnetic pole wheel with rotating permanent magnets. These encoders combine the disadvantages of an increased magnet demand and a limited maximal speed due to the centripetal force acting on the rotating magnets. The proposed approach reduces the total demand of permanent magnets drastically. Moreover, the rotating part is manufacturable from a single piece of steel, which makes it very robust and cheap. This work presents the theoretical operating principle of the proposed approach and validates its benefits on a hardware prototype. The presented proof-of-concept prototype achieves a mechanical resolution of 4.5 ° by using only 4 permanent magnets, 2Wiegand sensors and a rotating steel gear wheel with 20 teeth.},
  language  = {en}
}
@article{SeifarthGrosseGrossmannetal.2017,
  author    = {Seifarth, Volker and Grosse, Joachim O. and Grossmann, Matthias and Janke, Heinz Peter and Arndt, Patrick and Koch, Sabine and Epple, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation},
  series = {Journal of Biomaterials Applications},
  volume    = {32},
  journal   = {Journal of Biomaterials Applications},
  number    = {3},
  publisher = {Sage},
  address   = {London},
  issn      = {1530-8022},
  doi       = {10.1177/0885328217723178},
  pages     = {321 -- 330},
  year      = {2017},
  language  = {en}
}
@article{SeifarthGossmannGrosseetal.2015,
  author    = {Seifarth, Volker and Goßmann, Matthias and Grosse, J. O. and Becker, C. and Heschel, I. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds},
  series = {Urologia Internationalis},
  volume    = {2015},
  journal   = {Urologia Internationalis},
  number    = {95},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0042-1138},
  doi       = {10.1159/000368419},
  pages     = {106 -- 113},
  year      = {2015},
  language  = {en}
}
@article{BergmannGoettenBraunetal.2022,
  author    = {Bergmann, Ole and G{\"o}tten, Falk and Braun, Carsten and Janser, Frank},
  title     = {Comparison and evaluation of blade element methods against RANS simulations and test data},
  series = {CEAS Aeronautical Journal},
  volume    = {13},
  journal   = {CEAS Aeronautical Journal},
  publisher = {Springer},
  address   = {Wien},
  issn      = {1869-5590 (Online)},
  doi       = {10.1007/s13272-022-00579-1},
  pages     = {535 -- 557},
  year      = {2022},
  abstract  = {This paper compares several blade element theory (BET) method-based propeller simulation tools, including an evaluation against static propeller ground tests and high-fidelity Reynolds-Average Navier Stokes (RANS) simulations. Two proprietary propeller geometries for paraglider applications are analysed in static and flight conditions. The RANS simulations are validated with the static test data and used as a reference for comparing the BET in flight conditions. The comparison includes the analysis of varying 2D aerodynamic airfoil parameters and different induced velocity calculation methods. The evaluation of the BET propeller simulation tools shows the strength of the BET tools compared to RANS simulations. The RANS simulations underpredict static experimental data within 10\% relative error, while appropriate BET tools overpredict the RANS results by 15-20\% relative error. A variation in 2D aerodynamic data depicts the need for highly accurate 2D data for accurate BET results. The nonlinear BET coupled with XFOIL for the 2D aerodynamic data matches best with RANS in static operation and flight conditions. The novel BET tool PropCODE combines both approaches and offers further correction models for highly accurate static and flight condition results.},
  language  = {en}
}
@article{Alexopoulos2012,
  author    = {Alexopoulos, Spiros},
  title     = {Biogas systems: basics, biogas multifunction, principle of fermentation and hybrid application with a solar tower for the treatment of waste animal manure},
  series = {Journal of Engineering Science and Technology Review},
  volume    = {5},
  journal   = {Journal of Engineering Science and Technology Review},
  number    = {4},
  issn      = {1791-2377},
  pages     = {48 -- 55},
  year      = {2012},
  abstract  = {Two of the main environmental problems of today's society are the continuously increasing production of organic wastes as well as the increase of carbon dioxide in the atmosphere and the related green house effect. A way to solve these problems is the production of biogas. Biogas is a combustible gas consisting of methane, carbon dioxide and small amounts of other gases and trace elements. Production of biogas through anaerobic digestion of animal manure and slurries as well as of a wide range of digestible organic wastes and agricultural residues, converts these substrates into electricity and heat and offers a natural fertiliser for agriculture. The microbiological process of decomposition of organic matter, in the absence of oxygen takes place in reactors, called digesters. Biogas can be used as a fuel in a gas turbine or burner and can be used in a hybrid solar tower system offering a solution for waste treatment of agricultural and animal residues. A solar tower system consists of a heliostat field, which concentrates direct solar irradiation on an open volumetric central receiver. The receiver heats up ambient air to temperatures of around 700°C. The hot air's heat energy is transferred to a steam Rankine cycle in a heat recovery steam generator (HRSG). The steam drives a steam turbine, which in turn drives a generator for producing electricity. In order to increase the operational hours of a solar tower power plant, a heat storage system and/ or hybridization may be considered. The advantage of solar-fossil hybrid power plants, compared to solar-only systems, lies in low additional investment costs due to an adaptable solar share and reduced technical and economical risks. On sunny days the hybrid system operates in a solar-only mode with the central receiver and on cloudy days and at night with the gas turbine only. As an alternative to methane gas, environmentally neutral biogas can be used for operating the gas turbine. Hence, the hybrid system is operated to 100\% from renewable energy sources},
  language  = {en}
}
@article{BialonskiCaronSchloenetal.2016,
  author    = {Bialonski, Stephan and Caron, David A. and Schloen, Julia and Feudel, Ulrike and Kantz, Holger and Moorthi, Stefanie D.},
  title     = {Phytoplankton dynamics in the Southern California Bight indicate a complex mixture of transport and biology},
  series = {Journal of Plankton Research},
  volume    = {38},
  journal   = {Journal of Plankton Research},
  number    = {4},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1464-3774},
  doi       = {10.1093/plankt/fbv122},
  pages     = {1077 -- 1091},
  year      = {2016},
  abstract  = {The stimulation and dominance of potentially harmful phytoplankton taxa at a given locale and time are determined by local environmental conditions as well as by transport to or from neighboring regions. The present study investigated the occurrence of common harmful algal bloom (HAB) taxa within the Southern California Bight, using cross-correlation functions to determine potential dependencies between HAB taxa and environmental factors, and potential links to algal transport via local hydrography and currents. A simulation study, in which Lagrangian particles were released, was used to assess travel times due to advection by prevailing ocean currents in the bight. Our results indicate that transport of some taxa may be an important mechanism for the expansion of their distributions into other regions, which was supported by mean travel times derived from our simulation study and other literature on ocean currents in the Southern California Bight. In other cases, however, phytoplankton dynamics were rather linked to local environmental conditions, including coastal upwelling events. Overall, our study shows that complex current patterns in the Southern California Bight may contribute significantly to the formation and expansion of HABs in addition to local environmental factors determining the spatiotemporal dynamics of phytoplankton blooms.},
  language  = {en}
}
@article{AlexopoulosBreitbachHoffschmidtetal.2008,
  author    = {Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Stobbe, P.},
  title     = {Computational fluid flow of porous resic ceramic filtering modules and optimization of the channel edge form geometry},
  series = {Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2},
  journal   = {Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2},
  publisher = {Filtech Exhibitions},
  address   = {Meerbusch},
  pages     = {300 -- 304},
  year      = {2008},
  language  = {en}
}
@article{RaffeisAdjeiKyeremehVroomenetal.2020,
  author    = {Raffeis, Iris and Adjei-Kyeremeh, Frank and Vroomen, Uwe and Westhoff, Elmar and Bremen, Sebastian and Hohoi, Alexandru and B{\"u}hrig-Polaczek, Andreas},
  title     = {Qualification of a Ni-Cu alloy for the laser powder bed fusion process (LPBF): Its microstructure and mechanical properties},
  series = {Applied Sciences},
  volume    = {10},
  journal   = {Applied Sciences},
  number    = {Art. 3401},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2076-3417},
  doi       = {10.3390/app10103401},
  pages     = {1 -- 15},
  year      = {2020},
  abstract  = {As researchers continue to seek the expansion of the material base for additive manufacturing, there is a need to focus attention on the Ni-Cu group of alloys which conventionally has wide industrial applications. In this work, the G-NiCu30Nb casting alloy, a variant of the Monel family of alloys with Nb and high Si content is, for the first time, processed via the laser powder bed fusion process (LPBF). Being novel to the LPBF processes, optimum LPBF parameters were determined, and hardness and tensile tests were performed in as-built conditions and after heat treatment at 1000 °C. Microstructures of the as-cast and the as-built condition were compared. Highly dense samples (99.8\% density) were achieved after varying hatch distance (80 µm and 140 µm) with scanning speed (550 mm/s-1500 mm/s). There was no significant difference in microhardness between varied hatch distance print sets. Microhardness of the as-built condition (247 HV0.2) exceeded the as-cast microhardness (179 HV0.2.). Tensile specimens built in vertical (V) and horizontal (H) orientations revealed degrees of anisotropy and were superior to conventionally reported figures. Post heat treatment increased ductility from 20\% to 31\% (V), as well as from 16\% to 25\% (H), while ultimate tensile strength (UTS) and yield strength (YS) were considerably reduced.},
  language  = {en}
}
@article{ElsenKraiss1999,
  author    = {Elsen, Ingo and Kraiss, Karl-Friedrich},
  title     = {System concept and realization of a scalable neurocomputing architecture},
  series = {Systems Analysis Modelling Simulation},
  volume    = {35},
  journal   = {Systems Analysis Modelling Simulation},
  number    = {4},
  publisher = {Gordon and Breach Science Publishers},
  address   = {Amsterdam},
  issn      = {0232-9298},
  pages     = {399 -- 419},
  year      = {1999},
  abstract  = {This paper describes the realization of a novel neurocomputer which is based on the concepts of a coprocessor. In contrast to existing neurocomputers the main interest was the realization of a scalable, flexible system, which is capable of computing neural networks of arbitrary topology and scale, with full independence of special hardware from the software's point of view. On the other hand, computational power should be added, whenever needed and flexibly adapted to the requirements of the application. Hardware independence is achieved by a run time system which is capable of using all available computing power, including multiple host CPUs and an arbitrary number of neural coprocessors autonomously. The realization of arbitrary neural topologies is provided through the implementation of the elementary operations which can be found in most neural topologies.},
  language  = {en}
}
@article{ElsenKraissKrumbiegeletal.1999,
  author    = {Elsen, Ingo and Kraiss, Karl-Friedrich and Krumbiegel, Dirk and Walter, Peter and Wickel, Jochen},
  title     = {Visual information retrieval for 3D product identification: a midterm report},
  series = {KI - K{\"u}nstliche Intelligenz},
  volume    = {13},
  journal   = {KI - K{\"u}nstliche Intelligenz},
  number    = {1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1610-1987},
  pages     = {64 -- 67},
  year      = {1999},
  language  = {en}
}
@article{DickhoffHorikawaFunke2021,
  author    = {Dickhoff, Jens and Horikawa, Atsushi and Funke, Harald},
  title     = {Hydrogen Combustion - new DLE Combustor Addresses NOx Emissions and Flashback},
  series = {Turbomachinery international : the global journal of energy equipment},
  volume    = {62},
  journal   = {Turbomachinery international : the global journal of energy equipment},
  number    = {4},
  publisher = {MJH Life Sciences},
  address   = {Cranbury},
  issn      = {2767-2328},
  pages     = {26 -- 27},
  year      = {2021},
  language  = {en}
}
@article{Gaigall2023,
  author    = {Gaigall, Daniel},
  title     = {Allocating and forecasting changes in risk},
  series = {Journal of risk},
  volume    = {25},
  journal   = {Journal of risk},
  number    = {3},
  editor    = {AitSahlia, Farid},
  publisher = {Infopro Digital Risk},
  address   = {London},
  issn      = {1755-2842},
  doi       = {10.21314/JOR.2022.048},
  pages     = {1 -- 24},
  year      = {2023},
  abstract  = {We consider time-dependent portfolios and discuss the allocation of changes in the risk of a portfolio to changes in the portfolio's components. For this purpose we adopt established allocation principles. We also use our approach to obtain forecasts for changes in the risk of the portfolio's components. To put the approach into practice we present an implementation based on the output of a simulation. Allocation is illustrated with an example portfolio in the context of Solvency II. The quality of the forecasts is investigated with an empirical study.},
  language  = {en}
}
@article{Gaigall2023,
  author    = {Gaigall, Daniel},
  title     = {On the applicability of several tests to models with not identically distributed random effects},
  series = {Statistics : A Journal of Theoretical and Applied Statistics},
  volume    = {57},
  journal   = {Statistics : A Journal of Theoretical and Applied Statistics},
  publisher = {Taylor \& Francis},
  address   = {London},
  isbn      = {0323-3944},
  issn      = {1029-4910},
  doi       = {10.1080/02331888.2023.2193748},
  pages     = {14 Seiten},
  year      = {2023},
  abstract  = {We consider Kolmogorov-Smirnov and Cram{\´e}r-von-Mises type tests for testing central symmetry, exchangeability, and independence. In the standard case, the tests are intended for the application to independent and identically distributed data with unknown distribution. The tests are available for multivariate data and bootstrap procedures are suitable to obtain critical values. We discuss the applicability of the tests to random effects models, where the random effects are independent but not necessarily identically distributed and with possibly unknown distributions. Theoretical results show the adequacy of the tests in this situation. The quality of the tests in models with random effects is investigated by simulations. Empirical results obtained confirm the theoretical findings. A real data example illustrates the application.},
  language  = {en}
}
@article{ElsenHartungHornetal.2001,
  author    = {Elsen, Ingo and Hartung, Frank and Horn, Uwe and Kampmann, Markus and Peters, Liliane},
  title     = {Streaming technology in 3G mobile communication systems},
  series = {Computer : innovative technology for computer professionals},
  volume    = {34},
  journal   = {Computer : innovative technology for computer professionals},
  number    = {9 Seiten},
  editor    = {Voas, Jeffrey},
  publisher = {IEEE},
  address   = {New York},
  issn      = {0018-9162},
  pages     = {46 -- 52},
  year      = {2001},
  abstract  = {Third-generation mobile communication systems will combine standardized streaming with a range of unique services to provide high-quality Internet content that meets the specific needs of the rapidly growing mobile market.},
  language  = {en}
}