@article{StadlerGarveyEmbsetal.2014,
  author    = {Stadler, Alexander Maximilian and Garvey, Christopher J. and Embs, Jan Peter and Koza, Michael Marek and Unruh, Tobias and Artmann, Gerhard and Zaccai, Guiseppe},
  title     = {Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study},
  series = {Biochimica et biophysica acta (BBA): General Subjects},
  volume    = {1840},
  journal   = {Biochimica et biophysica acta (BBA): General Subjects},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-8006 (E-Journal); 0304-4165 (Print)},
  doi       = {10.1016/j.bbagen.2014.06.007},
  pages     = {2989 -- 2999},
  year      = {2014},
  language  = {en}
}
@article{MalechaKlubertHeinenFuchs2014,
  author    = {Malecha, Hartmut and Klubert, J. and Heinen-Fuchs, Sabine},
  title     = {Laserscanning passe? 3-D-Oberfl{\"a}chenmodelle aus Bilddaten und deren messtechnischer Nutzen},
  series = {Wasserwirtschaft},
  volume    = {Jg. 104},
  journal   = {Wasserwirtschaft},
  number    = {Nr. 9},
  publisher = {Springer Vieweg},
  address   = {Wiesbaden},
  issn      = {0043-0978},
  pages     = {32 -- 35},
  year      = {2014},
  language  = {de}
}
@article{KluczkaEcksteinAlexopoulosetal.2014,
  author    = {Kluczka, Sven and Eckstein, Julian and Alexopoulos, Spiros and Vaeßen, Christiane and Roeb, Martin},
  title     = {Process simulation for solar steam and dry reforming},
  series = {Energy procedia : Proceedings of the SolarPACES 2013 International Conference},
  volume    = {49},
  journal   = {Energy procedia : Proceedings of the SolarPACES 2013 International Conference},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1876-6102 (E-Journal)},
  doi       = {10.1016/j.egypro.2014.03.092},
  pages     = {850 -- 859},
  year      = {2014},
  abstract  = {In co-operation with the German Aerospace Center, the Solar-Institut J{\"u}lich has been analyzing the different technologies that are available for methanol production from CO2 using solar energy. The aim of the project is to extract CO2 from industrial exhaust gases or directly from the atmosphere to recycle it by use of solar energy. Part of the study was the modeling and simulating of a methane reformer for the production of synthesis gas, which can be operated by solar or hybrid heat sources. The reformer has been simplified in such a way that the model is accurate and enables fast calculations. The developed pseudo-homogeneous one- dimensional model can be regarded as a kind of counter-current heat exchanger and is able to incorporate a steam reforming reaction as well as a dry reforming reaction.},
  language  = {en}
}
@article{RatkeMilowLisinskietal.2014,
  author    = {Ratke, Lorenz and Milow, Barbara and Lisinski, Susanne and Hoepfner, Sandra},
  title     = {On an effect of fine ceramic particles on the structure of aerogels},
  series = {Microgravity science and technology},
  volume    = {26},
  journal   = {Microgravity science and technology},
  publisher = {Springer Nature},
  address   = {Heidelberg},
  issn      = {0938-0108 ; 1875-0494},
  doi       = {10.1007/s12217-014-9380-2},
  pages     = {103 -- 110},
  year      = {2014},
  language  = {en}
}
@article{LeandroBungCarvalho2014,
  author    = {Leandro, J. and Bung, Daniel Bernhard and Carvalho, R.},
  title     = {Measuring void fraction and velocity fields of a stepped spillway for skimming flow using non-intrusive methods},
  series = {Experiments in fluids},
  journal   = {Experiments in fluids},
  number    = {55},
  publisher = {Springer Nature},
  address   = {Heidelberg},
  issn      = {0723-4864 (Print) ; 1432-1114 (Online)},
  doi       = {10.1007/s00348-014-1732-6},
  pages     = {Art. 1732},
  year      = {2014},
  language  = {en}
}
@article{Laack2014,
  author    = {Laack, Walter van},
  title     = {Nahtoderfahrungen aus medizinischer Sicht},
  series = {Deutsche medizinische Wochenschrift : DMW},
  volume    = {Jg. 139},
  journal   = {Deutsche medizinische Wochenschrift : DMW},
  number    = {H. 51/52},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {1439-4413 (E-Journal); 0012-0472 (Print); 1437-5982 (Print)},
  doi       = {10.1055/s-0034-1387363},
  pages     = {2651 -- 2654},
  year      = {2014},
  abstract  = {Nah- versus Nachtoderfahrungen Nahtoderfahrungen (NTE) sind ein Ph{\"a}nomen aus der Kategorie „außergew{\"o}hnliche Bewusstseinserfahrungen". Sie treten in unmittelbarer N{\"a}he des eigenen Todes auf. Oft, aber nicht immer, handelt es sich dabei um Erfahrungen von Personen, die durch {\"a}rztliche Maßnahmen wiederbelebt wurden und sp{\"a}ter davon berichten (NTE-ler). Jedoch kommen solche Ph{\"a}nomene auch bei Menschen vor, die w{\"a}hrend einer schweren Erkrankung eine lebensbedrohliche Krise haben, hiervon aber spontan genesen. Den NTE {\"a}hnlich sind auch sogenannte Nachtod-erfahrungen sowie spontane Erlebnisse, die im Rahmen anderer außergew{\"o}hnlicher Stresssituationen auftreten. Von Nachtoderfahrungen spricht man, wenn die Betroffenen anl{\"a}sslich des Todes von geliebten Angeh{\"o}rigen oder Freunden Erlebnisse haben, die inhaltlich ebenfalls, zumindest aber teilweise, denen von NTE entsprechen. Nachtoderfahrungen sowie spontane NTE-{\"a}hnliche Erlebnisse unterscheiden sich jedoch von den echten NTE zumeist sowohl quantitativ als auch qualitativ. Unter einem quantitativen Unterschied versteht man in diesem Zusammenhang eine in der Regel geringer ausgepr{\"a}gte Komplexit{\"a}t, als sie sehr vielen NTE zu eigen ist. Da sich aber auch viele NTE selbst bez{\"u}glich ihrer Komplexit{\"a}t unterscheiden, ist der Hauptunterschied qualitativer Natur: Echte NTE besitzen gegen{\"u}ber den anderen hier erw{\"a}hnten Ph{\"a}nomenen eine gr{\"o}ßere inhaltliche und emotionale Tiefe. Sie begleiten die Betroffenen anschließend ein Leben lang - zumeist mit positiven, in Einzelf{\"a}llen aber auch mit negativen Folgen, die bis zu einem sp{\"a}teren Suizid reichen k{\"o}nnen. Die genannten außergew{\"o}hnlichen Bewusstseinsph{\"a}nomene lassen sich in ihrer Gesamtheit bei rund 5 \% der Bev{\"o}lkerung finden. NTE im Speziellen haben hiervon einen durchaus bedeutenden Anteil. Je nach Studie geben zwischen 18 \% und 40 \% aller Personen, die reanimiert wurden, an, w{\"a}hrenddessen eine NTE erlebt zu haben. Dass nicht alle eine solche Erfahrung machen, wird von Kritikern gern dahingehend interpretiert, NTE seien rein physiologischer und keineswegs spiritueller Natur. Jedoch sollte man bedenken, dass im Fall einer rein neurophysiologischen Grundlage von NTE dann bei jedem ein solches Ph{\"a}nomen zu erwarten w{\"a}re, so wie beispielsweise auch die Symptome einer Hypoglyk{\"a}mie im Wesentlichen immer dieselben sind.},
  language  = {de}
}
@article{Balzer2014,
  author    = {Balzer, Hermann},
  title     = {Ausgestaltung und Steuerung des Netzes von Bankbeziehungen - Update nach 25 Jahren mithilfe einer explorativen Unternehmensbefragung / Arbeitskreis Finanzierung der Schmalenbach-Gesellschaft e.V. unter Mitarb. von Prof. Dr. Hermann Balzer...},
  series = {Zfbf : Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung},
  journal   = {Zfbf : Schmalenbachs Zeitschrift f{\"u}r betriebswirtschaftliche Forschung},
  number    = {H. 8},
  publisher = {Springer Gabler},
  address   = {Wiesbaden},
  issn      = {0341-2687},
  pages     = {694 -- 723},
  year      = {2014},
  language  = {de}
}
@article{GuoSekiMiyamotoetal.2014,
  author    = {Guo, Yuanyuan and Seki, Kosuke and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo},
  title     = {Device simulation of the light-addressable potentiometric sensor with a novel photoexcitation method for a higher spatial resolution},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.369},
  pages     = {456 -- 459},
  year      = {2014},
  abstract  = {A novel photoexcitation method for the light-addressable potentiometric sensor (LAPS) realized a higher spatial resolution of chemical imaging. In this method, a modulated light probe, which generates the alternating photocurrent signal, is surrounded by a ring of constant light, which suppresses the lateral diffusion of photocarriers by enhancing recombination. A device simulation verified that a higher spatial resolution could be obtained by adjusting the gap between the modulated and constant light. It was also found that a higher intensity and a longer wavelength of constant light was more effective. However, there exists a tradeoff between the spatial resolution and the amplitude of the photocurrent, and thus, the signal-to-noise ratio. A tilted incidence of constant light was applied, which could achieve even higher resolution with a smaller loss of photocurrent.},
  language  = {en}
}
@article{MiyamotoSekiWagneretal.2014,
  author    = {Miyamoto, K. and Seki, K. and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, T.},
  title     = {Enhancement of the spatial resolution of the chemical imaging sensor by a hybrid fiber-optic illumination},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.563},
  pages     = {612 -- 615},
  year      = {2014},
  abstract  = {The chemical imaging sensor, which is based on the principle of the light-addressable potentiometric sensor (LAPS), is a powerful tool to visualize the spatial distribution of chemical species on the sensor surface. The spatial resolution of this sensor depends on the diffusion of photocarriers excited by a modulated light. In this study, a novel hybrid fiber-optic illumination was developed to enhance the spatial resolution. It consists of a modulated light probe to generate a photocurrent signal and a ring of constant light, which suppresses the lateral diffusion of minority carriers excited by the modulated light. It is demonstrated that the spatial resolution was improved from 92 μm to 68 μm.},
  language  = {en}
}
@article{BronderWuPoghossianetal.2014,
  author    = {Bronder, Thomas and Wu, Chunsheng and Poghossian, Arshak and Werner, Frederik and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Label-free detection of DNA hybridization with light-addressable potentiometric sensors: comparison of various DNA-immobilization strategies},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.647},
  pages     = {755 -- 758},
  year      = {2014},
  abstract  = {Light-addressable potentiometric sensors (LAPS) consisting of a p-Si-SiO2 and p-Si-SiO2-Au structure, respectively, have been tested for a label-free electrical detection of DNA (deoxyribonucleic acid) hybridization. Three different strategies for immobilizing single-stranded probe DNA (ssDNA) molecules on a LAPS surface have been studied and compared: (a) immobilization of thiol-modified ssDNA on the patterned Au surface via gold-thiol bond, (b) covalent immobilization of amino-modified ssDNA onto the SiO2 surface functionalized with 3-aminopropyltriethoxysilane and (c) layer-by-layer adsorption of negatively charged ssDNA on a positively charged weak polyelectrolyte layer of poly(allylamine hydrochloride).},
  language  = {en}
}
@article{HuckPoghossianBaeckeretal.2014,
  author    = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Reisert, Steffen and Schubert, J. and Zander, W. and Begoyan, V. K. and Buniatyan, V. V. and Sch{\"o}ning, Michael Josef},
  title     = {Chemical sensors based on a high-k perovskite oxide of barium strontium titanate},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.258},
  pages     = {28 -- 31},
  year      = {2014},
  abstract  = {High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor.},
  language  = {en}
}
@article{SchusserBaeckerKrischeretal.2014,
  author    = {Schusser, Sebastian and B{\"a}cker, Matthias and Krischer, M. and Wenzel, L. and Leinhos, Marcel and Poghossian, Arshak and Biselli, Manfred and Wagner, P. and Sch{\"o}ning, Michael Josef},
  title     = {Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.689},
  pages     = {1314 -- 1317},
  year      = {2014},
  abstract  = {A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.},
  language  = {en}
}
@article{FeichtingerEilmannBuchmannetal.2014,
  author    = {Feichtinger, Linda M. and Eilmann, Britta and Buchmann, Nina and Rigling, Andreas},
  title     = {Growth adjustments of conifers to drought and to century-long irrigation},
  series = {Forest Ecology and Management},
  volume    = {2014},
  journal   = {Forest Ecology and Management},
  number    = {334},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-7042 (Online)},
  doi       = {10.1016/j.foreco.2014.08.008},
  pages     = {96 -- 105},
  year      = {2014},
  abstract  = {Our knowledge on tree responses to drought is mainly based on short-term manipulation experiments which do not capture any possible long-term adjustments in this response. Therefore, historical water channels in inner-Alpine dry valleys were used as century-long irrigation experiments to investigate adjustments in tree growth to contrasting water supply. This involved quantifying the tree-ring growth of irrigated and non-irrigated (control) Scots pine (Pinus sylvestris L.) in Valais (Switzerland), as well as European larch (Larix decidua Mill.) and black pine (Pinus nigra Arnold) in Vinschgau (Italy). Furthermore, the adjustments in radial growth of Scots pine and European larch to an abrupt stop in irrigation were analyzed. Irrigation promoted the radial growth of all tree species investigated compared to the control: (1) directly through increased soil water availability, and (2) indirectly through increased soil nutrients and humus contents in the irrigated plots. Irrigation led to a full elimination of growth responses to climate for European larch and black pine, but not for Scots pine, which might become more sensitive to drought with increasing tree size in Valais. For the control trees, the response of the latewood increment to water availability in July/August has decreased in recent decades for all species, but increased in May for Scots pine only. The sudden irrigation stop caused a drop in radial growth to a lower level for Scots pine or similar level for larch compared to the control for up to ten years. However, both tree species were then able to adjust to the new conditions and subsequently grew with similar (Scots pine) or even higher growth rates (larch) than the control. To estimate the impact of climate change on future forest development, the duration of manipulation experiments should be on longer time scales in order to capture adjustment processes and feedback mechanisms of forest ecosystems.},
  language  = {en}
}
@article{EilmannSterckWegneretal.2014,
  author    = {Eilmann, Britta and Sterck, Frank J. and Wegner, L. and de Vries, Sven M. G. and von Arx, G. and Mohren, Godefridus M. J. and den Ouden, Jan and Sass-Klaassen, Ute G. W.},
  title     = {Wood structural differences between northern and southern beech provenances growing at a moderate site},
  series = {Tree Physiology},
  volume    = {34},
  journal   = {Tree Physiology},
  number    = {8},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1758-4469 (Online)},
  doi       = {10.1093/treephys/tpu069},
  pages     = {882 -- 893},
  year      = {2014},
  language  = {en}
}
@article{LevesqueSiegwolfEilmannetal.2014,
  author    = {L{\´e}vesque, Mathieu and Siegwolf, Rolf and Eilmann, Britta and Saurer, Matthias and Rigling, Andreas},
  title     = {Increased water-use efficiency does not lead to enhanced tree growth under xeric and mesic conditions},
  series = {New Phytologist},
  volume    = {203},
  journal   = {New Phytologist},
  number    = {1},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1469-8137 (Online)},
  doi       = {10.1111/nph.12772},
  pages     = {94 -- 109},
  year      = {2014},
  language  = {en}
}
@article{Stulpe2014,
  author    = {Stulpe, Werner},
  title     = {From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations},
  series = {Journal of Mathematical Physics},
  volume    = {55},
  journal   = {Journal of Mathematical Physics},
  number    = {1},
  publisher = {AIP Publishing},
  address   = {College Park, Md.},
  issn      = {222-488},
  doi       = {10.1063/1.4861939},
  pages     = {Artikel 012109},
  year      = {2014},
  abstract  = {The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered.},
  language  = {en}
}
@article{DachwaldMikuckiTulaczyketal.2014,
  author    = {Dachwald, Bernd and Mikucki, Jill and Tulaczyk, Slawek and Digel, Ilya and Espe, Clemens and Feldmann, Marco and Francke, Gero and Kowalski, Julia and Xu, Changsheng},
  title     = {IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems},
  series = {Annals of Glaciology},
  volume    = {55},
  journal   = {Annals of Glaciology},
  number    = {65},
  publisher = {Cambridge University Press},
  address   = {Cambridge},
  issn      = {1727-5644},
  doi       = {10.3189/2014AoG65A004},
  pages     = {14 -- 22},
  year      = {2014},
  abstract  = {There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample.},
  language  = {en}
}
@article{BaeckerSchusserPoghossianetal.2014,
  author    = {B{\"a}cker, Matthias and Schusser, Sebastian and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Multi-Parametererfassung mit siliziumbasiertem Sensorchip: Aus Drei mach Eins},
  series = {GIT Labor-Fachzeitschrift},
  journal   = {GIT Labor-Fachzeitschrift},
  number    = {2},
  publisher = {Wiley},
  issn      = {0016-3538},
  pages     = {28 -- 30},
  year      = {2014},
  language  = {de}
}
@article{AlmajhdiSengerAmeretal.2014,
  author    = {Almajhdi, Fahad N. and Senger, Tilo and Amer, Haitham M. and Gissmann, Lutz and {\"O}hlschl{\"a}ger, Peter},
  title     = {Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)},
  series = {PLOS one},
  volume    = {11},
  journal   = {PLOS one},
  number    = {9},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0113461},
  pages     = {e113461},
  year      = {2014},
  abstract  = {Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.},
  language  = {en}
}
@article{Wollert2014,
  author    = {Wollert, J{\"o}rg},
  title     = {Funkstandards f{\"u}r Sensornetzwerke},
  series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler},
  volume    = {Bd. 63},
  journal   = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler},
  number    = {H. 12},
  publisher = {WEKA-Fachmedien},
  address   = {Haar},
  issn      = {0013-5658},
  pages     = {36 -- 41},
  year      = {2014},
  language  = {de}
}
@article{Wollert2014,
  author    = {Wollert, J{\"o}rg},
  title     = {Echtzeit-Ethernet : Protokoll-Reigen},
  series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler},
  volume    = {Bd. 63},
  journal   = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler},
  number    = {H. 26},
  publisher = {WEKA-Fachmedien},
  address   = {Haar},
  issn      = {0013-5658},
  pages     = {24 -- 31},
  year      = {2014},
  language  = {de}
}
@article{Wollert2014,
  author    = {Wollert, J{\"o}rg},
  title     = {Der Embedded Wireless-Report},
  series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme},
  journal   = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme},
  publisher = {WEKA-Fachmedien},
  address   = {Haar},
  issn      = {0013-5658},
  pages     = {18 -- 25},
  year      = {2014},
  language  = {de}
}
@article{Wollert2014,
  author    = {Wollert, J{\"o}rg},
  title     = {Echtzeit-Ethernet mit Standardtechnik},
  series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Embedded : Fachmagazin f{\"u}r die Entwicklung von Embedded-Systemen},
  volume    = {Bd. 63},
  journal   = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Embedded : Fachmagazin f{\"u}r die Entwicklung von Embedded-Systemen},
  number    = {H. 12},
  publisher = {WEKA-Fachmedien},
  address   = {Haar},
  issn      = {0013-5658},
  pages     = {28 -- 32},
  year      = {2014},
  language  = {de}
}
@article{Wollert2014,
  author    = {Wollert, J{\"o}rg},
  title     = {Feldbustechnologie},
  series = {Factory : der Durchblick in der Technik},
  journal   = {Factory : der Durchblick in der Technik},
  publisher = {WEKA-Industriemedien},
  address   = {Wien},
  pages     = {Publ. online},
  year      = {2014},
  language  = {de}
}
@article{WallenbornRitz2014,
  author    = {Wallenborn, Ramona and Ritz, Thomas},
  title     = {Mobilit{\"a}t miteinander teilen : st{\"a}dtisches eCarsharing in einer vernetzten Gesellschaft ; [vernetztes Fahren von morgen]},
  series = {Neue Mobilit{\"a}t : das Magazin vom Bundesverband eMobilit{\"a}t},
  volume    = {5},
  journal   = {Neue Mobilit{\"a}t : das Magazin vom Bundesverband eMobilit{\"a}t},
  number    = {14 (Herbstausg.)},
  publisher = {Bundesverband eMobilit{\"a}t BEM},
  address   = {Berlin},
  issn      = {2191-5636},
  pages     = {92 -- 95},
  year      = {2014},
  language  = {de}
}
@article{DemnyHebel2014,
  author    = {Demny, Andreas and Hebel, Christoph},
  title     = {Rechnergest{\"u}tzte Ermittlung der Verbindungsfunktionsstufen und der verbindungsbezogenen Angebotsqualit{\"a}t nach den Richtlinien f{\"u}r integrierte Netzgestaltung nach RIN 2008},
  series = {Straßenverkehrstechnik : Organ der Forschungsgesellschaft f{\"u}r Straßen- und Verkehrswesen, der Bundesvereinigung der Straßenbau- und Verkehrsingenieure und der {\"O}sterreichischen Forschungsgesellschaft Straße und Verkehr ; Zeitschrift f{\"u}r Verkehrsplanung, Verkehrsmanagement, Verkehrssicherheit, Verkehrstechnik},
  volume    = {Jg. 58},
  journal   = {Straßenverkehrstechnik : Organ der Forschungsgesellschaft f{\"u}r Straßen- und Verkehrswesen, der Bundesvereinigung der Straßenbau- und Verkehrsingenieure und der {\"O}sterreichischen Forschungsgesellschaft Straße und Verkehr ; Zeitschrift f{\"u}r Verkehrsplanung, Verkehrsmanagement, Verkehrssicherheit, Verkehrstechnik},
  number    = {H. 12},
  publisher = {Kirschbaum Verlag},
  address   = {Bonn},
  issn      = {0039-2219},
  pages     = {811 -- 820},
  year      = {2014},
  language  = {de}
}
@article{Thomas2014,
  author    = {Thomas, Axel},
  title     = {Generation Y},
  series = {P.T. : Magazin f{\"u}r Wirtschaft und Gesellschaft},
  volume    = {10},
  journal   = {P.T. : Magazin f{\"u}r Wirtschaft und Gesellschaft},
  number    = {3},
  publisher = {OPS Netzwerk},
  address   = {Leipzig},
  issn      = {1860-501X},
  pages     = {6 -- 9},
  year      = {2014},
  language  = {de}
}
@article{ThomasWassenberg2014,
  author    = {Thomas, Axel and Wassenberg, Gerd},
  title     = {Erfolgreich sein im Kampf um die besten Talente : Employer Branding},
  series = {Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen},
  journal   = {Wirtschaftliche Nachrichten der Industrie- und Handelskammer Aachen},
  publisher = {IHK Aachen},
  address   = {Aachen},
  year      = {2014},
  language  = {de}
}
@article{RitzPisarczykSachtlebenetal.2014,
  author    = {Ritz, Thomas and Pisarczyk, Rafael and Sachtleben, Johanna and Leßenich, Nina},
  title     = {Usability Engineering maßgeschneidert : Modellbaukasten zur Entwicklung gebrauchstauglicher mobiler Software},
  series = {Wissenschaft trifft Praxis},
  volume    = {1},
  journal   = {Wissenschaft trifft Praxis},
  number    = {1},
  publisher = {Begleitforschung Mittelstand-Digital c/o WIK-Consult GmbH},
  address   = {Bad Honnef},
  issn      = {2198-8544 (Print)},
  pages     = {79 -- 88},
  year      = {2014},
  language  = {de}
}
@article{MartinGonzalezKotliarRiosMartinezetal.2014,
  author    = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir},
  title     = {Mediated-reality magnification for macular degeneration rehabilitation},
  series = {Journal of Modern Optics},
  volume    = {61},
  journal   = {Journal of Modern Optics},
  number    = {17},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1362-3044},
  doi       = {10.1080/09500340.2014.936110},
  pages     = {1400 -- 1408},
  year      = {2014},
  language  = {en}
}
@article{GellertButenweg2014,
  author    = {Gellert, Christoph and Butenweg, Christoph},
  title     = {Seismic analysis of masonry structures in German earthquake zones according to DIN EN 1998-1},
  series = {Mauerwerk : European journal of masonry},
  volume    = {18},
  journal   = {Mauerwerk : European journal of masonry},
  number    = {3-4},
  publisher = {Ernst \& Sohn},
  address   = {Berlin},
  issn      = {1437-1022 (E-Journal); 1432-3427 (Print)},
  doi       = {10.1002/dama.201400626},
  pages     = {188 -- 196},
  year      = {2014},
  abstract  = {Die Erdbeben in Albstadt 1978 (Magnitude 5,7), Roermond 1992 (Magnitude 5,9) oder in Waldkirch 2004 (Magnitude 5,1) haben verdeutlicht, dass die erdbebensichere Auslegung von Mauerwerksbauten auch in Deutschland von großer Bedeutung ist. Bereits im Jahr 1981 wurde die DIN 4149 (1981) "Bauten in deutschen Erdbebengebieten - Lastannahmen, Bemessung und Ausf{\"u}hrung {\"u}blicher Hochbauten" eingef{\"u}hrt, in der aber f{\"u}r Mauerwerksbauten nur wenige Anforderungen gestellt wurden. Diese Norm wurde durch den NABau-Arbeitsausschuss "Erdbeben; Sonderfragen" des Deutschen Instituts f{\"u}r Normung e.V. (DIN) auf Grundlage des Eurocode 8 (2004) vollst{\"a}ndig {\"u}berarbeitet und durch die DIN 4149 (2005) abgel{\"o}st, die umfangreiche Regelungen f{\"u}r die seismische Auslegung von Mauerwerksbauten enth{\"a}lt. Mittlerweile liegen die DIN EN 1998-1 (2010) und der Nationale Anhang DIN EN 1998-1/NA (2011) vor, die nach Einarbeitung der Ergebnisse der durchgef{\"u}hrten Anwendungserprobung bauaufsichtlich eingef{\"u}hrt und die DIN 4149 (2005) ersetzen werden. Der folgende Beitrag gibt einen {\"U}berblick {\"u}ber die seismische Berechnung und Bemessung von Mauerwerksbauten nach dem europ{\"a}ischen Regelwerk und illustriert deren Anwendung an einem baupraktischen Beispiel.},
  language  = {de}
}
@article{ButenwegMeyerFehling2014,
  author    = {Butenweg, Christoph and Meyer, Udo and Fehling, Ekkehard},
  title     = {EU-Projekt INSYSME: Innovative Techniken f{\"u}r erdbebensichere Ausfachungsw{\"a}nde aus Ziegelmauerwerk in Stahlbetonrahmentragwerken},
  series = {Mauerwerk : European journal of masonry},
  volume    = {18},
  journal   = {Mauerwerk : European journal of masonry},
  number    = {2},
  publisher = {Ernst \& Sohn},
  address   = {Berlin},
  issn      = {1437-1022 (E-Journal); 1432-3427 (Print)},
  doi       = {10.1002/dama.201400612},
  pages     = {78 -- 81},
  year      = {2014},
  abstract  = {Am 1. Oktober 2013 ist das auf drei Jahre angelegte EU-Forschungsprojekt INSYSME - Innovative Systeme f{\"u}r erdbebentaugliche Ausfachungsw{\"a}nde aus Ziegelmauerwerk in Stahlbetonrahmentragwerken - gestartet. Unter der Koordination der Universit{\"a}t Padua beteiligen sich 16 Partner aus sechs europ{\"a}ischen L{\"a}ndern (Deutschland, Griechenland, Italien, Portugal, Rum{\"a}nien, T{\"u}rkei). Als deutsche Partner nehmen die Arbeitsgemeinschaft Mauerziegel aus Bonn, die Universit{\"a}t Kassel sowie das Ingenieurb{\"u}ro SDA-engineering GmbH aus Herzogenrath, teil. Ziel der deutschen Partner ist die Entwicklung von innovativen Ausfachungssystemen aus monolithischem w{\"a}rmed{\"a}mmenden Ziegelmauerwerk, mit denen nicht nur eine erh{\"o}hte Erdbebensicherheit, sondern auch die sichere Erf{\"u}llung der steigenden Anforderungen aus Windbeanspruchungen gew{\"a}hrleistet werden k{\"o}nnen. Die Forschungsergebnisse sollen vom Partner SDA-engineering GmbH in die bereits seit einigen Jahren verf{\"u}gbare Softwarel{\"o}sung MINEA [1] integriert werden. Weitere Informationen stehen auf den Websites des Projektes [2] zur Verf{\"u}gung. Im vorliegenden Beitrag werden nach einer kurzen thematischen Einf{\"u}hrung die Ergebnisse von Tastversuchen an senkrecht zur Ebene belasteten Ausfachungsw{\"a}nden aus Planziegelmauerwerk vorgestellt. Im Anschluss wird das geplante Arbeitsprogramm der deutschen Partner im Projekt INSYSME beschrieben.},
  language  = {de}
}
@article{ButenwegSchmittRosen2014,
  author    = {Butenweg, Christoph and Schmitt, Timo and Rosen, Britta},
  title     = {Seismische Einwirkungen auf erdverlegte Rohrleitungssysteme},
  series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik},
  volume    = {89 (2014)},
  journal   = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik},
  number    = {Heft 7/8},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {0005-6650},
  pages     = {316 -- 324},
  year      = {2014},
  language  = {de}
}
@article{MeyerButenwegFehling2014,
  author    = {Meyer, Udo and Butenweg, Christoph and Fehling, Ekkehard},
  title     = {EU-Projekt INSYSME : innovative Systeme f{\"u}r erdbebentaugliche Ausfachungsw{\"a}nde aus Ziegelmauerwerk},
  series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt},
  volume    = {89 (2014)},
  journal   = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt},
  number    = {April},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {1436-4867 (E-Journal); 0005-6650 (Print)},
  pages     = {S14 -- S15},
  year      = {2014},
  language  = {de}
}
@article{ButenwegRenault2014,
  author    = {Butenweg, Christoph and Renault, Philippe},
  title     = {Workshop der Gesellschaften zum EU-Projekt SHARE},
  series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt},
  volume    = {89 (2014)},
  journal   = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik. Beilage: D-A-CH-Mitteilungsblatt},
  number    = {Oktober},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {1436-4867 (E-Journal); 0005-6650 (Print)},
  pages     = {S2 -- S3},
  year      = {2014},
  language  = {de}
}
@article{HaagZontarSchleupenetal.2014,
  author    = {Haag, S. and Zontar, D. and Schleupen, Josef and M{\"u}ller, T. and Brecher, C.},
  title     = {Chain of refined perception in self-optimizing assembly of micro-optical systems},
  series = {Journal of sensors and sensor systems},
  volume    = {3},
  journal   = {Journal of sensors and sensor systems},
  number    = {1},
  publisher = {Copernicus Publ.},
  address   = {G{\"o}ttingen},
  issn      = {2194-878X},
  doi       = {10.5194/jsss-3-87-2014},
  pages     = {87 -- 95},
  year      = {2014},
  abstract  = {Today, the assembly of laser systems requires a large share of manual operations due to its complexity regarding the optimal alignment of optics. Although the feasibility of automated alignment of laser optics has been shown in research labs, the development effort for the automation of assembly does not meet economic requirements - especially for low-volume laser production. This paper presents a model-based and sensor-integrated assembly execution approach for flexible assembly cells consisting of a macro-positioner covering a large workspace and a compact micromanipulator with camera attached to the positioner. In order to make full use of available models from computer-aided design (CAD) and optical simulation, sensor systems at different levels of accuracy are used for matching perceived information with model data. This approach is named "chain of refined perception", and it allows for automated planning of complex assembly tasks along all major phases of assembly such as collision-free path planning, part feeding, and active and passive alignment. The focus of the paper is put on the in-process image-based metrology and information extraction used for identifying and calibrating local coordinate systems as well as the exploitation of that information for a part feeding process for micro-optics. Results will be presented regarding the processes of automated calibration of the robot camera as well as the local coordinate systems of part feeding area and robot base.},
  language  = {en}
}
@article{ScheerMclaughlinRodeetal.2014,
  author    = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.},
  title     = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057885},
  pages     = {1022 -- 1030},
  year      = {2014},
  abstract  = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.},
  language  = {en}
}
@article{LuisierLempiaeinenScherbichleretal.2014,
  author    = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.},
  title     = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors},
  series = {Toxicological Sciences},
  volume    = {139},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {https://doi.org/10.1093/toxsci/kfu038},
  pages     = {501 -- 511},
  year      = {2014},
  abstract  = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.},
  language  = {en}
}
@article{SalpatiChuChenetal.2014,
  author    = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja},
  title     = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {8},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057976},
  pages     = {1301 -- 1313},
  year      = {2014},
  abstract  = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.},
  language  = {en}
}
@article{ScheerWolf2014,
  author    = {Scheer, Nico and Wolf, C. Roland},
  title     = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications},
  series = {Xenobiotica},
  volume    = {44},
  journal   = {Xenobiotica},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1366-5928},
  doi       = {10.3109/00498254.2013.815831},
  pages     = {96 -- 108},
  year      = {2014},
  abstract  = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.},
  language  = {en}
}
@article{AkimbekovDigelZhubanova2014,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Zhubanova, A. A.},
  title     = {Advantages of creation of e-books in training of specialists biologists and biotechnologists},
  series = {KazNU Bulletin. Biology series.},
  volume    = {60},
  journal   = {KazNU Bulletin. Biology series.},
  number    = {1},
  publisher = {Al-Farabi Kazakh National University},
  address   = {Almaty},
  issn      = {1563-0218},
  pages     = {249 -- 252},
  year      = {2014},
  abstract  = {The necessity of e-books as a primary of learning, its opportunities for realization of competence during training biologist and biotechnologist specialists are determined. Definitions and requirements to the e-books, its advantages in comparison with traditional textbooks, and the ways of creation of e-books in the SunRav BookEditor program are considered.},
  language  = {ru}
}
@article{AkimbekovDigelOHerasetal.2014,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and O´Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice husks obtained in the batch experiments},
  series = {Experimental Biology},
  volume    = {60},
  journal   = {Experimental Biology},
  number    = {1/2},
  publisher = {Al-Farabi Kazakh National University},
  address   = {Almaty},
  issn      = {1563-0218},
  pages     = {144 -- 148},
  year      = {2014},
  abstract  = {The scope of this study is the measurement of endotoxin adsorption rate for carbonized rice husk. It showed good adsorption properties for LPS. During the batch experiments, several techniques were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics.},
  language  = {en}
}
@article{ButenwegSchmittRosen2014,
  author    = {Butenweg, Christoph and Schmitt, T. and Rosen, B.},
  title     = {Seismische Einwirkungen auf erdverlegte Rohrleitungen},
  series = {Bauingenieur},
  volume    = {89},
  journal   = {Bauingenieur},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {0005-6650},
  pages     = {316 -- 324},
  year      = {2014},
  abstract  = {Die erdbebensichere Auslegung von erdverlegten Rohrleitungssystemen ist von wesentlicher Bedeutung zur Sicherstellung der Funktionalit{\"a}t der Versorgungsinfrastruktur nach einem Erdbebenereignis. Zur Vermeidung von Netzausf{\"a}llen ist es erforderlich, die r{\"a}umlich weit ausgedehnten Leitungssysteme mit geeigneten rechnerischen Modellen seismisch zu bemessen. Der vorliegende Beitrag behandelt die Beanspruchung von Rohrleitungssystemen durch seismische Welleneinwirkung und stellt geeignete N{\"a}herungsans{\"a}tze und ein detailliertes Rechenmodell f{\"u}r seismische Leitungsanalysen vor. Mit den Ans{\"a}tzen wird in Berechnungsbeispielen der Einfluss wesentlicher Parameter auf die seismisch induzierten Dehnungen in Rohrleitungssystemen untersucht.},
  language  = {de}
}
@article{PasteurTippkoetterKampeisetal.2014,
  author    = {Pasteur, Aline and Tippk{\"o}tter, Nils and Kampeis, Percy and Ulber, Roland},
  title     = {Optimization of high gradient magnetic separation filter units for the purification of fermentation products},
  series = {IEEE TRANSACTIONS ON MAGNETICS},
  volume    = {50},
  journal   = {IEEE TRANSACTIONS ON MAGNETICS},
  number    = {10},
  publisher = {IEEE},
  address   = {New York, NY},
  issn      = {0018-9464},
  doi       = {10.1109/TMAG.2014.2325535},
  pages     = {Artikel 5000607},
  year      = {2014},
  abstract  = {High gradient magnetic separation (HGMS) has been established since the early 1970s. A more recent application of these systems is the use in bioprocesses. To integrate the HGMS in a fermentation process, it is necessary to optimize the separation matrix with regard to the magnetic separation characteristics and permeability of the non-magnetizable components of the fermentation broth. As part of the work presented here, a combined fluidic and magnetic force finite element model simulation was created using the software COMSOL Multiphysics and compared with separation experiments. Finally, as optimal lattice orientation of the separation matrix, a transversal rhombohedral arrangement was defined. The high suitability of the new filter matrix has been verified by separation experiments.},
  language  = {en}
}
@article{TippkoetterWollnySucketal.2014,
  author    = {Tippk{\"o}tter, Nils and Wollny, Steffen and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland},
  title     = {Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense},
  series = {Engineering in Life Sciences},
  volume    = {14},
  journal   = {Engineering in Life Sciences},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1618-2863},
  doi       = {10.1002/elsc.201300113},
  pages     = {425 -- 432},
  year      = {2014},
  abstract  = {A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.},
  language  = {en}
}
@article{AlKaidyDuweHusteretal.2014,
  author    = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Sieker, Tim and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Biotechnologie und Bioverfahrenstechnik - Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {12},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201400083},
  pages     = {2215 -- 2225},
  year      = {2014},
  abstract  = {Biotechnologie und die mit ihr verbundenen technischen Prozesse pr{\"a}gen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und t{\"a}glichen Gebrauchsg{\"u}tern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verst{\"a}ndnis zellul{\"a}rer Vorg{\"a}nge k{\"o}nnen mittlerweile Produktionsst{\"a}mme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik k{\"o}nnen so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt.},
  language  = {de}
}
@article{WiesenTippkoetterMuffleretal.2014,
  author    = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Nils and Ulber, Roland},
  title     = {Adsorptive Vorbehandlung von Rohglycerin f{\"u}r die 1,3-Propandiol Fermentation mit Clostridium diolis},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {1-2},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  doi       = {10.1002/cite.201300080},
  pages     = {129 -- 135},
  year      = {2014},
  abstract  = {Bei der Gewinnung von Fetts{\"a}uren aus Pflanzen{\"o}len, z. B. zur Herstellung von Biopolymeren, oder bei der Biodiesel- und Seifenproduktion, f{\"a}llt Glycerin als Nebenprodukt an. Bei der Biokonversion dieses Rohstoffes zu 1,3-Propandiol wird der Produktionsorganismus Clostridium diolis durch Verunreinigungen im Rohglycerin gehemmt. Als inhibierende Substanzen konnten freie Fetts{\"a}uren identifiziert werden. Mithilfe eines adsorptiven Aufarbeitungsverfahrens ist es gelungen, die Fetts{\"a}uren zu entfernen und die Konversionseffizienz zu 1,3-Propandiol zu erh{\"o}hen.},
  language  = {de}
}
@article{JoerissenHeger2014,
  author    = {J{\"o}rissen, J{\"o}rg and Heger, Michael},
  title     = {Zur Wirkung hochschuldidaktisch fundierter und in den Fachbereichen verankerter Lehrveranstaltungsevaluation},
  series = {Qualit{\"a}t in der Wissenschaft (QiW)},
  volume    = {8},
  journal   = {Qualit{\"a}t in der Wissenschaft (QiW)},
  number    = {2+3},
  publisher = {Universit{\"a}tsverlag Webler},
  address   = {Bielefeld},
  issn      = {1860-3041},
  pages     = {70 -- 80},
  year      = {2014},
  language  = {de}
}
@article{HoehrPaulssenBenardetal.2014,
  author    = {Hoehr, Cornelia and Paulßen, Elisabeth and Benard, Francois and Lee, Chris Jaeil and Hou, Xinchi and Badesso, Brian and Ferguson, Simon and Miao, Qing and Yang, Hua and Buckley, Ken and Hanemaayer, Victoire and Zeisler, Stefan and Ruth, Thomas and Celler, Anna and Schaffer, Paul},
  title     = {⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron},
  series = {Nuclear medicine and biology},
  volume    = {41},
  journal   = {Nuclear medicine and biology},
  number    = {5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9614},
  doi       = {10.1016/j.nucmedbio.2013.12.016},
  pages     = {401 -- 406},
  year      = {2014},
  abstract  = {Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27\%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.},
  language  = {en}
}
@article{Wilke2014,
  author    = {Wilke, Thomas},
  title     = {Gebaute Geschichte in Turin},
  series = {Kunsttexte.de},
  volume    = {2014},
  journal   = {Kunsttexte.de},
  number    = {1},
  publisher = {Humboldt-Universit{\"a}t zu Berlin},
  address   = {Berlin},
  issn      = {1618-8101},
  doi       = {10.18452/7197},
  pages     = {13 Seiten},
  year      = {2014},
  abstract  = {St{\"a}dte sind Stein gewordene Geschichte. Ihre realisierte Form erm{\"o}glicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der f{\"u}hrenden Barockmetropolen Europas beeinflusste.},
  language  = {de}
}