@article{BaeckerKochEibenetal.2017, author = {B{\"a}cker, Matthias and Koch, Claudia and Eiben, Sabine and Geiger, Fania and Eber, Fabian and Gliemann, Hartmut and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors}, series = {Sensors and Actuators B: Chemical}, volume = {238}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.07.096}, pages = {716 -- 722}, year = {2017}, abstract = {The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.}, language = {en} } @article{KochPoghossianSchoeningetal.2018, author = {Koch, Claudia and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Wege, Christian}, title = {Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors}, series = {Nanotheranostics}, volume = {2}, journal = {Nanotheranostics}, number = {2}, publisher = {Ivyspring}, address = {Sydney}, issn = {2206-7418}, doi = {10.7150/ntno.22114}, pages = {184 -- 196}, year = {2018}, abstract = {The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.}, language = {en} } @article{EschWoltersSalberetal.2001, author = {Esch, Thomas and Wolters, Peter and Salber, Wolfgang and Geiger, Jos{\´e}}, title = {Variable Ventilsteuerung und Direkteinspritzung - vom Wettbewerb zur Synergie}, series = {Motor und Umwelt 2001, Internal Combustion Engine Versus Fuel Cell - Potential and Limitations as Automotive Power Sources, Verbrennungsmotor versus Brennstoffzelle - Potenziale und Grenzen f{\"u}r den Automobilantrieb, Proc., Graz, AT, 6.-7. Sep, 2001}, journal = {Motor und Umwelt 2001, Internal Combustion Engine Versus Fuel Cell - Potential and Limitations as Automotive Power Sources, Verbrennungsmotor versus Brennstoffzelle - Potenziale und Grenzen f{\"u}r den Automobilantrieb, Proc., Graz, AT, 6.-7. Sep, 2001}, pages = {183 -- 206}, year = {2001}, language = {de} } @article{SpietzSproewitzSeefeldtetal.2021, author = {Spietz, Peter and Spr{\"o}witz, Tom and Seefeldt, Patric and Grundmann, Jan Thimo and Jahnke, Rico and Mikschl, Tobias and Mikulz, Eugen and Montenegro, Sergio and Reershemius, Siebo and Renger, Thomas and Ruffer, Michael and Sasaki, Kaname and Sznajder, Maciej and T{\´o}th, Norbert and Ceriotti, Matteo and Dachwald, Bernd and Macdonald, Malcolm and McInnes, Colin and Seboldt, Wolfgang and Quantius, Dominik and Bauer, Waldemar and Wiedemann, Carsten and Grimm, Christian D. and Hercik, David and Ho, Tra-Mi and Lange, Caroline and Schmitz, Nicole}, title = {Paths not taken - The Gossamer roadmap's other options}, series = {Advances in Space Research}, volume = {67}, journal = {Advances in Space Research}, number = {9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, doi = {10.1016/j.asr.2021.01.044}, pages = {2912 -- 2956}, year = {2021}, language = {en} } @article{SchmitzPischinger1997, author = {Schmitz, G{\"u}nter and Pischinger, Martin}, title = {Mechatronische Simulation eines EMV- Aktuators}, series = {TransMechatronik : Entwicklung und Transfer von Entwicklungssystemen der Mechatronik / Paderborner Workshop TransMechatronik, 24. Juni 1997, Heinz-Nixdorf-MuseumsForum. [Hrsg. J{\"u}rgen Gausemeier]}, journal = {TransMechatronik : Entwicklung und Transfer von Entwicklungssystemen der Mechatronik / Paderborner Workshop TransMechatronik, 24. Juni 1997, Heinz-Nixdorf-MuseumsForum. [Hrsg. J{\"u}rgen Gausemeier]}, publisher = {Heinz-Nixdorf-Inst., Univ.-GH Paderborn}, address = {Paderborn}, isbn = {3-931466-22-1}, pages = {69 -- 83}, year = {1997}, language = {de} } @article{EschGoebelPischinger1995, author = {Esch, Thomas and G{\"o}bel, T. and Pischinger, Martin}, title = {Variable Ventilsteuerung - Luft- und Kraftstoffzumessung bei Ottomotoren mit variabler Ventilsteuerung}, series = {Forschungsberichte Verbrennungskraftmaschinen. 578 (1995)}, journal = {Forschungsberichte Verbrennungskraftmaschinen. 578 (1995)}, pages = {1 -- 42}, year = {1995}, language = {de} } @article{BegingMlynekHataihimakuletal.2010, author = {Beging, Stefan and Mlynek, Daniela and Hataihimakul, Sudkanung and Poghossian, Arshak and Baldsiefen, Gerhard and Busch, Heinz and Laube, Norbert and Kleinen, Lisa and Sch{\"o}ning, Michael Josef}, title = {Field-effect calcium sensor for the determination of the risk of urinary stone formation}, series = {Sensors and Actuators B: Chemical}, volume = {144}, journal = {Sensors and Actuators B: Chemical}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2008.12.012}, pages = {374 -- 379}, year = {2010}, abstract = {Urinary stone formation has been evolved to a widespread disease during the last years. The reason for the formation of urinary stones are little crystals, mostly composed of calcium oxalate, which are formed in human kidneys. The early diagnosis of the risk for urinary stone formation of patients can be determined by the "Bonn-Risk-Index" method based on the potentiometric detection of the Ca2+-ion concentration and an optical determination of the triggered crystallisation of calcium oxalate in unprocessed urine. In this work, miniaturised capacitive field-effect EMIS (electrolyte-membrane-insulator-semiconductor) sensors have been developed for the determination of the Ca2+-ion concentration in human native urine. The Ca2+-sensitive EMIS sensors have been systematically characterised by impedance spectroscopy, capacitance-voltage and constant-capacitance method in terms of sensitivity, signal stability and response time in both CaCl2 solutions and in native urine. The obtained results demonstrate the suitability of EMIS sensors for the measurement of the Ca2+-ion concentration in native urine of patients.}, language = {en} } @article{ReisertHenkelSchneideretal.2010, author = {Reisert, Steffen and Henkel, Hartmut and Schneider, Andreas and Sch{\"a}fer, Daniel and Friedrich, Peter and Berger, J{\"o}rg and Sch{\"o}ning, Michael Josef}, title = {Development of a handheld sensor system for the online measurement of hydrogen peroxide in aseptic filling systems}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6300}, doi = {10.1002/pssa.200983304}, pages = {913 -- 918}, year = {2010}, abstract = {A handheld sensor system for the online measurement of hydrogen peroxide (H2O2) in aseptic sterilisation processes has been developed. It is based on a calorimetric-type gas sensor that consists of a differential set-up of two temperature sensors, of which one is catalytically activated and the second one is passivated and used as reference. The sensor principle relies in detecting a rise in temperature on the active sensor due to the exothermic reaction of H2O2 on the catalytic surface. To characterise the sensor system towards H2O2 sensitivity and other influencing factors, measurements have been carried out both at an experimental set-up and a manufacturer's sterilisation machine. Physical sensor characterisation was done by means of the optical microscopy.}, language = {en} } @article{MiyamotoSugawaraKanohetal.2010, author = {Miyamoto, Ko-ichiro and Sugawara, Yuri and Kanoh, Shin´ichiro and Yoshinobu, Tatsuo and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Image correction method for the chemical imaging sensor}, series = {Sensors and Actuators B: Chemical}, volume = {144}, journal = {Sensors and Actuators B: Chemical}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2008.10.069}, pages = {344 -- 348}, year = {2010}, abstract = {The chemical imaging sensor is a semiconductor-based chemical sensor that can visualize the spatial distribution of chemical species. For the practical application of this sensor, artifacts in the chemical images due to defects of the semiconductor substrate and contamination of the sensing surface etc. have been a major problem. An image correction method was developed to eliminate the influence of nonuniformity of individual sensor plate.}, language = {en} } @article{UndenBeckerBongaertsetal.1995, author = {Unden, Gottfried and Becker, S. and Bongaerts, Johannes and Holighaus, G. and Schirawski, Jan and Six, Simon}, title = {O2-sensing and O2-dependent gene regulation in facultatively anaerobic bacteria}, series = {Archives of microbiology}, volume = {Vol. 164}, journal = {Archives of microbiology}, number = {Iss. 2}, issn = {1432-072X (E-Journal); 0003-9276 (Print); 0302-8933 (Print)}, pages = {81 -- 90}, year = {1995}, language = {en} } @article{HoffschmidtBeckerFend2006, author = {Hoffschmidt, Bernhard and Becker, Manfred and Fend, Thomas}, title = {Theoretical and numerical investigation of flow stability in porous materials applied as volumetric solar receivers / M. Becker ; T. Fend ; B. Hoffschmidt ...}, series = {Solar energy. 80 (2006), H. 10}, journal = {Solar energy. 80 (2006), H. 10}, isbn = {0038-092X}, pages = {1241 -- 1248}, year = {2006}, language = {en} } @article{UndenBeckerBongaertsetal.1994, author = {Unden, Gottfried and Becker, S. and Bongaerts, Johannes and Schirawski, Jan and Six, Simon}, title = {Oxygen regulated gene expression in facultatively anaerobic bacteria}, series = {Antonie van Leeuwenhoek}, volume = {Vol. 66}, journal = {Antonie van Leeuwenhoek}, number = {Iss. 1-3}, issn = {0003-6072 (Print) ; 1572-9699 (online)}, pages = {3 -- 22}, year = {1994}, language = {en} } @article{AbouzarPoghossianSiqueiraetal.2010, author = {Abouzar, Maryam H. and Poghossian, Arshak and Siqueira, Jos{\´e} R. Jr. and Oliveira, Osvaldo N. Jr. and Moritz, Werner and Sch{\"o}ning, Michael Josef}, title = {Capacitive electrolyte-insulator-semiconductor structures functionalised with a polyelectrolyte/enzyme multilayer: New strategy for enhanced field-effect biosensing}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6300}, doi = {10.1002/pssa.200983317}, pages = {884 -- 890}, year = {2010}, abstract = {A novel strategy for enhanced field-effect biosensing using capacitive electrolyte-insulator-semiconductor (EIS) structures functionalised with pH-responsive weak polyelectrolyte/enzyme or dendrimer/enzyme multilayers is presented. The feasibility of the proposed approach is exemplarily demonstrated by realising a penicillin biosensor based on a capacitive p-Si-SiO2 EIS structure functionalised with a poly(allylamine hydrochloride) (PAH)/penicillinase and a poly(amidoamine) dendrimer/penicillinase multilayer. The developed sensors response to changes in both the local pH value near the gate surface and the charge of macromolecules induced via enzymatic reaction, resulting in a higher sensitivity. For comparison, an EIS penicillin biosensor with adsorptively immobilised penicillinase has been also studied. The highest penicillin sensitivity of 100 mV/dec has been observed for the EIS sensor functionalised with the PAH/penicillinase multilayer. The lower and upper detection limit was around 20 µM and 10 mM, respectively. In addition, an incorporation of enzymes in a multilayer prepared by layer-by-layer technique provides a larger amount of immobilised enzymes per sensor area, reduces enzyme leaching effects and thus, enhances the biosensor lifetime (the loss of penicillin sensitivity after 2 months was 10-12\%).}, language = {en} } @article{SchoeningTsarouchasBeckersetal.1996, author = {Sch{\"o}ning, Michael Josef and Tsarouchas, D. and Beckers, Leah and Schubert, J. and Zander, W. and Kordoš, P. and L{\"u}th, Hans}, title = {A highly long-term stable silicon-based pH sensor using pulsed laser deposition technique}, series = {Sensors and Actuators B. 35 (1996), H. 1-3}, journal = {Sensors and Actuators B. 35 (1996), H. 1-3}, isbn = {0925-4005}, pages = {228 -- 233}, year = {1996}, language = {en} } @article{SchoeningPraemassingBeckersetal.1998, author = {Sch{\"o}ning, Michael Josef and Pr{\"a}massing, T. and Beckers, Leah and Zander, W.}, title = {Ein langzeitstabiler pH-Sensor auf Siliziumbasis hergestellt in D{\"u}nnschichttechnik mittels Laserablation}, series = {Chemie- und Biosensoren : aktuelle Anwendungen und Entwicklungstrends / 3. Dresdner Sensor-Symposium, 8. - 10. Dezember 1997, Dresden-Radebeul. J. P. Baselt ... (Hg.)}, journal = {Chemie- und Biosensoren : aktuelle Anwendungen und Entwicklungstrends / 3. Dresdner Sensor-Symposium, 8. - 10. Dezember 1997, Dresden-Radebeul. J. P. Baselt ... (Hg.)}, publisher = {Dresden Univ. Press}, address = {Dresden ; M{\"u}nchen}, isbn = {3-933168-03-1}, pages = {99 -- 102}, year = {1998}, language = {de} } @article{SchmitzRoetertPischinger1988, author = {Schmitz, G{\"u}nter and Roetert, J. and Pischinger, Martin}, title = {A Fast Intelligent VMEbus System for Combustion Analysis in Engines}, series = {19th [nineteenth] International Symposium on Automotive Technology \& [and] Automation : with particular reference to cell control and quality management systems for the manufacturing industries; Monte Carlo, 24. - 28. October 1988.}, journal = {19th [nineteenth] International Symposium on Automotive Technology \& [and] Automation : with particular reference to cell control and quality management systems for the manufacturing industries; Monte Carlo, 24. - 28. October 1988.}, publisher = {Automotive Automation Ltd}, address = {Croydon}, isbn = {0947719229}, pages = {381 -- 391}, year = {1988}, language = {en} } @article{PoghossianJablonskiKochetal.2018, author = {Poghossian, Arshak and Jablonski, Melanie and Koch, Claudia and Bronder, Thomas and Rolka, David and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Field-effect biosensor using virus particles as scaffolds for enzyme immobilization}, series = {Biosensors and Bioelectronics}, volume = {110}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2018.03.036}, pages = {168 -- 174}, year = {2018}, abstract = {A field-effect biosensor employing tobacco mosaic virus (TMV) particles as scaffolds for enzyme immobilization is presented. Nanotubular TMV scaffolds allow a dense immobilization of precisely positioned enzymes with retained activity. To demonstrate feasibility of this new strategy, a penicillin sensor has been developed by coupling a penicillinase with virus particles as a model system. The developed field-effect penicillin biosensor consists of an Al-p-Si-SiO₂-Ta₂O₅-TMV structure and has been electrochemically characterized in buffer solutions containing different concentrations of penicillin G. In addition, the morphology of the biosensor surface with virus particles was characterized by scanning electron microscopy and atomic force microscopy methods. The sensors possessed a high penicillin sensitivity of ~ 92 mV/dec in a nearly-linear range from 0.1 mM to 10 mM, and a low detection limit of about 50 µM. The long-term stability of the penicillin biosensor was periodically tested over a time period of about one year without any significant loss of sensitivity. The biosensor has also been successfully applied for penicillin detection in bovine milk samples.}, language = {en} } @article{SchoeningKirchnerNgetal.2010, author = {Sch{\"o}ning, Michael Josef and Kirchner, Patrick and Ng, Yue Ann and Spelthahn, Heiko and Schneider, Andreas and Henkel, Hartmut and Friedrich, Peter and Kolstad, Jens and Berger, J{\"o}rg and Keusgen, Michael}, title = {Gas sensor investigation based on a catalytically activated thin-film thermopile for H2O2 detection}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6300}, doi = {10.1002/pssa.200983309}, pages = {787 -- 792}, year = {2010}, abstract = {In aseptic filling systems, hydrogen peroxide vapour is commonly used for the reduction of microbial contaminations in carton packages. In this process, the germicidal efficiency of the vapour depends especially on the H₂O₂ concentration. To monitor the H₂O₂ concentration, a calorimetric H₂O₂ gas sensor based on a catalytically activated thin-film thermopile is investigated. Two different sensor layouts, namely a circular and a linear form, as well as two various material pairs such as tungsten/nickel and gold/nickel, have been examined for the realization of a thin-film thermopile. Additionally, manganese oxide and palladium particles have been compared as responsive catalysts towards H₂O₂. The thin-film sensors have been investigated at various H₂O₂ concentrations, gas temperatures and flow rates.}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Chaudhuri, S. and Zander, W. and Schubert, J. and Begoyan, Vardges K. and Buniatyan, V. V. and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate}, series = {Sensors and actuators. B: Chemical}, journal = {Sensors and actuators. B: Chemical}, number = {198}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.02.103}, pages = {102 -- 109}, year = {2014}, language = {en} } @article{GrundmannDachwaldGrimmetal.2015, author = {Grundmann, Jan Thimo and Dachwald, Bernd and Grimm, Christian D. and Kahle, Ralph and Koch, Aaron Dexter and Krause, Christian and Lange, Caroline and Quantius, Dominik and Ulamec, Stephan}, title = {Spacecraft for Hypervelocity Impact Research - An Overview of Capabilities, Constraints and the Challenges of Getting There}, series = {Procedia Engineering}, volume = {Vol. 103}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.04.021}, pages = {151 -- 158}, year = {2015}, language = {en} } @article{BuniatyanAbouzarMartirosyanetal.2010, author = {Buniatyan, Vahe V. and Abouzar, Maryam H. and Martirosyan, Norayr W. and Schubert, J{\"u}rgen and Gevorgian, Spartak and Sch{\"o}ning, Michael Josef and Poghossian, Arshak}, title = {pH-sensitive properties of barium strontium titanate (BST) thin films prepared by pulsed laser deposition technique}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6300}, doi = {10.1002/pssa.200983310}, pages = {824 -- 830}, year = {2010}, abstract = {pH-sensitive properties of barium strontium titanate (BST) high-k thin films as alternative gate material for field-effect capacitive (bio-)chemical sensors based on an electrolyte-insulator-semiconductor system have been investigated. The BST films of different compositions (Ba0.31Sr0.69TiO3, Ba0.25Sr0.75TiO3 and Mg-doped Ba0.8Sr0.2Mg0.1Ti0.9O3) were deposited by pulsed laser deposition technique from targets fabricated by self-propagating high-temperature synthesis. The realised sensors have been electrochemically characterised by means of impedance-spectroscopy, capacitance-voltage and constant-capacitance method. The sensors possess a Nernstian-like pH sensitivity in the concentration range between pH 3 and 11 with a response time of 5-10 s. An equivalent circuit model for the BST-based capacitive field-effect sensor is discussed.}, language = {en} } @article{TurekHeidenGuoetal.2010, author = {Turek, Monik and Heiden, Wolfgang and Guo, Sharon and Riesen, Alfred and Schubert, J{\"u}rgen and Zander, Willi and Kr{\"u}ger, Peter and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6300}, doi = {10.1002/pssa.200983303}, pages = {817 -- 823}, year = {2010}, abstract = {In environmental analysis, cyanide and heavy metals play an important role, because these substances are highly toxic for biological systems. They can lead to chronic and acute diseases. Due to the chemical properties of cyanide it is frequently used for industrial processes such as extraction of silver and gold. Heavy metals can be found as trace elements in nature and are often applied in industries e.g., galvanization processes. Up to now, cyanide and heavy metals can be detected by several sensors separately and their detection is often limited to laboratory investigations. In this publication, with regard to an in situ analysis, a new miniaturized silicon-based sensor system for the simultaneous detection of cyanide and heavy metals in aqueous solutions is presented that is based on chalcogenide glass-based micro ion-selective electrodes (µISEs). The µISEs are incorporated into a specially designed measuring system for the simultaneous detection of heavy metals and cyanide in solutions and validated by simultaneous measurements of Cu2+- and CN--ions, Cd2+- and CN-- ions and Pb2+- and CN--ions. The particular sensor system has shown good sensor properties in the µ-molar ion-concentration range. For simultaneous measurements in complex heavy metal and cyanide solutions an intelligent software using fuzzy logic is discussed.}, language = {en} } @article{JansenBehbahaniLaumenetal.2010, author = {Jansen, S. V. and Behbahani, Mehdi and Laumen, M. and Kaufmann, T. and Hormes, M. and Behr, Marek and Schmitz-Rode, T. and Steinseifer, U.}, title = {Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation}, series = {ASAIO Journal}, volume = {56}, journal = {ASAIO Journal}, number = {2}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, doi = {10.1097/01.mat.0000369377.65122.a3}, pages = {98}, year = {2010}, language = {en} } @article{BehbahaniProbstMaietal.2010, author = {Behbahani, Mehdi and Probst, M. and Mai, A. and Tran, L. and Vonderstein, K. and Keschenau, P. and Linde, T. and Steinseifer, U. and Behr, Marek and Mottaghy, K.}, title = {The influence of high shear on thrombosis and hemolysis in artificial organs}, series = {The International Journal of Artificial Organs}, volume = {33}, journal = {The International Journal of Artificial Organs}, number = {7}, publisher = {Sage}, address = {Thousand Oaks}, issn = {0391-3988}, pages = {426 -- 426}, year = {2010}, language = {en} } @article{BehbahaniNamWalugaetal.2010, author = {Behbahani, Mehdi and Nam, J. and Waluga, C. and Behr, Marek and Pasquali, M. and Mottaghy, K.}, title = {Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs}, volume = {56}, number = {2}, publisher = {Lippincott Williams \& Wilkins}, address = {Philadelphia}, doi = {10.1097/01.mat.0000369377.65122.a3}, pages = {85}, year = {2010}, language = {en} } @article{BehbahaniBehrBischofetal.2007, author = {Behbahani, Mehdi and Behr, Marek and Bischof, F. and Wolf, G. E.}, title = {Kranken Herzen helfen - Ingenieure und Informatiker entwickeln gemeinsam eine Miniaturblutpumpe / Behbahani, M. ; Behr, M. ; Bischof, F. ; Wolf, G. E.}, series = {RWTH-Themen (2007)}, journal = {RWTH-Themen (2007)}, isbn = {0179-079X}, pages = {44 -- 46}, year = {2007}, language = {de} } @article{SchoeningBeckersSchaubetal.1996, author = {Sch{\"o}ning, Michael Josef and Beckers, Leah and Schaub, A. and Zander, W. and Schubert, J. and Mesters, S. and Kordos, P. and L{\"u}th, H.}, title = {A novel silicon-based pH sensor prepared by pulsed laser deposition technique}, series = {Proceedings of Eurosensors X, the 10th European Conference on Solid-State Transducers, September 8-11, 1996, Leuven, Belgium / [KU Leuven]. Puers, Robert. Vol. 3.}, journal = {Proceedings of Eurosensors X, the 10th European Conference on Solid-State Transducers, September 8-11, 1996, Leuven, Belgium / [KU Leuven]. Puers, Robert. Vol. 3.}, publisher = {Catholic University Leuven}, address = {Heverlee, Belgium}, isbn = {90-803282-1-9}, pages = {781 -- 784}, year = {1996}, language = {en} } @article{ElbersPfefferFrieseletal.1993, author = {Elbers, Gereon and Pfeffer, H.-U. and Friesel, J. and Beier, Reinhold}, title = {Pilotuntersuchungen gem{\"a}ß dem Verordnungsentwurf nach \S 40, Abs. 2 des Bundesimmissionsschutzgesetzes / H.-U. Pfeffer, J. Friesel, G. Elbers, R. Beier, K. Ellermann}, series = {Drei Jahrzehnte Luftqualit{\"a}ts{\"u}berwachung : Vortr{\"a}ge und Berichte zum Kolloquium "Drei Jahrzehnte Luftqualit{\"a}ts{\"u}berwachung - Bilanz und Perspektiven" am 11. November 1993 in Essen / [Hrsg.: Landesanstalt f{\"u}r Immissionsschutz Nordrhein-Westfalen. Red. Bearb.: Robert Niesenhaus]}, journal = {Drei Jahrzehnte Luftqualit{\"a}ts{\"u}berwachung : Vortr{\"a}ge und Berichte zum Kolloquium "Drei Jahrzehnte Luftqualit{\"a}ts{\"u}berwachung - Bilanz und Perspektiven" am 11. November 1993 in Essen / [Hrsg.: Landesanstalt f{\"u}r Immissionsschutz Nordrhein-Westfalen. Red. Bearb.: Robert Niesenhaus]}, address = {Essen}, pages = {117}, year = {1993}, language = {de} } @article{BehbahaniMaiWalugaetal.2010, author = {Behbahani, Mehdi and Mai, A. and Waluga, C. and Bergmann, B. and Tran, L. and Vonderstein, K. and Behr, Marek and Mottaghy, K.}, title = {Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions}, series = {Acta Physiologica}, volume = {198}, journal = {Acta Physiologica}, number = {Supplement 677}, isbn = {1748-1716}, pages = {185}, year = {2010}, language = {en} } @article{SiqueiraBaeckerPoghossianetal.2010, author = {Siqueira, Jos{\´e} R. Jr. and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices}, series = {Physica Status Solidi (A)}, volume = {207}, journal = {Physica Status Solidi (A)}, number = {4}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6300}, doi = {10.1002/pssa.200983301}, pages = {781 -- 786}, year = {2010}, abstract = {The control of molecular architecture provided by the layer-by-layer (LbL) technique has led to enhanced biosensors, in which advantageous features of distinct materials can be combined. Full optimization of biosensing performance, however, is only reached if the film morphology is suitable for the principle of detection of a specific biosensor. In this paper, we report a detailed morphology analysis of LbL films made with alternating layers of single-walled carbon nanotubes (SWNTs) and polyamidoamine (PAMAM) dendrimers, which were then covered with a layer of penicillinase (PEN). An optimized performance to detect penicillin G was obtained with 6-bilayer SWNT/PAMAM LbL films deposited on p-Si-SiO2-Ta2O5 chips, used in biosensors based on a capacitive electrolyte-insulator-semiconductor (EIS) and a light-addressable potentiometric sensor (LAPS) structure, respectively. Field-emission scanning electron microscopy (FESEM) and atomic force microscopy (AFM) images indicated that the LbL films were porous, with a large surface area due to interconnection of SWNT into PAMAM layers. This morphology was instrumental for the adsorption of a larger quantity of PEN, with the resulting LbL film being highly stable. The experiments to detect penicillin were performed with constant-capacitance (ConCap) and constant-current (CC) measurements for EIS and LAPS sensors, respectively, which revealed an enhanced detection signal and sensitivity of ca. 100 mV/decade for the field-effect sensors modified with the PAMAM/SWNT LbL film. It is concluded that controlling film morphology is essential for an enhanced performance of biosensors, not only in terms of sensitivity but also stability and response time.}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Reisert, Steffen and Schubert, J. and Zander, W. and Begoyan, Vardges K. and Buniatyan, V. V. and Sch{\"o}ning, Michael Josef}, title = {Chemical sensors based on a high-k perovskite oxide of barium strontium titanate}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.258}, pages = {28 -- 31}, year = {2014}, abstract = {High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor.}, language = {en} } @article{GosslaButtelWahrmundetal.2010, author = {Gossla, Ulrich and Buttel, Luc and Wahrmund, Holger and Mehlig, Bernd}, title = {Bemessung, Anwendung und Qualit{\"a}tssicherung von Stahlfaserspritzbeton im Tunnelbau}, series = {Beton- und Stahlbetonbau}, volume = {105}, journal = {Beton- und Stahlbetonbau}, number = {2}, publisher = {Ernst \& Sohn}, address = {Berlin}, issn = {0005-9900}, doi = {10.1002/best.200900688}, pages = {92 -- 101}, year = {2010}, abstract = {Die Spritzbetonbauweise hat sich im Tunnelbau seit Jahren bew{\"a}hrt. Spritzbeton wird als unbewehrter Beton, in Verbindung mit Bewehrung sowie als Stahlfaserspritzbeton eingesetzt. Bei den meisten Tunnelschalen aus Stahlfaserspritzbeton werden Stahlfasern derzeit nur als konstruktive Bewehrung verwendet. Die Faserzugabe f{\"u}hrt zu einer nennenswerten Erh{\"o}hung der Bruchenergie und somit zu einer h{\"o}heren Z{\"a}higkeit des sonst spr{\"o}den Materials und damit zu einer h{\"o}heren Sicherheit. Stahlfaserspritzbeton kann auch anstelle von Spritzbeton mit statisch erforderlicher Mattenbewehrung eingesetzt werden. Die Bemessung erfolgt dann unter Ber{\"u}cksichtigung der Nachrisszugfestigkeit. Diese kann wie bei Stahlfaserbeton an Biegebalken ermittelt werden, die aus gr{\"o}ßeren Proben herausges{\"a}gt werden. Anhand von verschiedenen Beispielen werden die unterschiedlichen Anwendungen aufgezeigt und die daf{\"u}r erforderlichen Pr{\"u}fungen vorgestellt.}, language = {de} } @article{BehbahaniTranWalugaetal.2009, author = {Behbahani, Mehdi and Tran, L. and Waluga, C. and Behr, Marek and Oedekoven, B. and Mottaghy, K.}, title = {Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices}, series = {The International Journal of Artificial Organs. 32 (2009), H. 7}, journal = {The International Journal of Artificial Organs. 32 (2009), H. 7}, isbn = {0391-3988}, pages = {398 -- 398}, year = {2009}, language = {en} } @article{SchoeningSchaubZundeletal.1995, author = {Sch{\"o}ning, Michael Josef and Schaub, A. and Zundel, A. and Beckers, Leah and Schubert, J. and Zander, W. and Kordos, P. and L{\"u}th, H.}, title = {Pulsed laser deposition as a novel thin film preparation method for silicon-based field effect sensors}, series = {Proceedings of the 25th European Solid State Device Research Conference : the Netherlands Congress Centre, The Hague, the Netherlands, 25th - 27th September 1995 / ESSDERC '95. Ed. by H. C. de Graaff}, journal = {Proceedings of the 25th European Solid State Device Research Conference : the Netherlands Congress Centre, The Hague, the Netherlands, 25th - 27th September 1995 / ESSDERC '95. Ed. by H. C. de Graaff}, publisher = {Ed. Fronti{\`e}res}, address = {Gif-sur-Yvette}, isbn = {2-86332-182-X}, pages = {601 -- 604}, year = {1995}, language = {en} } @article{BehbahaniBehrAroraetal.2006, author = {Behbahani, Mehdi and Behr, Marek and Arora, D. and Coronado, O. and Pasquali, M.}, title = {CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M.}, series = {Artificial Organs. 30 (2006), H. 11}, journal = {Artificial Organs. 30 (2006), H. 11}, isbn = {1525-1594}, pages = {A45 -- A46}, year = {2006}, language = {en} } @article{BehbahaniBehrHormesetal.2009, author = {Behbahani, Mehdi and Behr, Marek and Hormes, M. and Steinseifer, U. and Arora, D. and Coronado, O. and Pasquali, M.}, title = {A Review of Computational Fluid Dynamics Analysis of Blood Pumps}, series = {European Journal of Applied Mathematics. 20 (2009), H. 4}, journal = {European Journal of Applied Mathematics. 20 (2009), H. 4}, publisher = {Cambridge Univ. Press}, address = {Cambridge}, pages = {363 -- 397}, year = {2009}, language = {en} } @article{BehbahaniTranJockenhoeveletal.2011, author = {Behbahani, Mehdi and Tran, L. and Jockenh{\"o}vel, S. and Behr, Marek and Mottaghy, K.}, title = {Numerical prediction of thrombocyte reactions for application to a vascular flow model}, series = {British Journal of Surgery}, volume = {98}, journal = {British Journal of Surgery}, number = {S5}, publisher = {Oxford University Press}, address = {Oxford}, isbn = {1365-2168}, pages = {S17}, year = {2011}, language = {en} } @article{RibitschHeumannKarletal.2012, author = {Ribitsch, Doris and Heumann, Sonja and Karl, Wolfgang and Gerlach, Jochen and Leber, R. and Birner-Gruenberger, R. and Gruber, K. and Eiteljoerg, I. and Remler, Peter and Siegert, Petra and Lange, J. and Maurer, Karl-Heinz and Berg, G. and Guebitz, G. M. and Schwab, H.}, title = {Extracellular serine proteases from Stenotrophomonas maltophilia: Screening, isolation and heterologous expression in E. coli}, series = {Journal of biotechnology}, volume = {157}, journal = {Journal of biotechnology}, number = {1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4863 (E-Journal); 0168-1656 (Print)}, doi = {10.1016/j.jbiotec.2011.09.025}, pages = {140 -- 147}, year = {2012}, abstract = {A large strain collection comprising antagonistic bacteria was screened for novel detergent proteases. Several strains displayed protease activity on agar plates containing skim milk but were inactive in liquid media. Encapsulation of cells in alginate beads induced protease production. Stenotrophomonas maltophilia emerged as best performer under washing conditions. For identification of wash-active proteases, four extracellular serine proteases called StmPr1, StmPr2, StmPr3 and StmPr4 were cloned. StmPr2 and StmPr4 were sufficiently overexpressed in E. coli. Expression of StmPr1 and StmPr3 resulted in unprocessed, insoluble protein. Truncation of most of the C-terminal domain which has been identified by enzyme modeling succeeded in expression of soluble, active StmPr1 but failed in case of StmPr3. From laundry application tests StmPr2 turned out to be a highly wash-active protease at 45 °C. Specific activity of StmPr2 determined with suc-l-Ala-l-Ala-l-Pro-l-Phe-p-nitroanilide as the substrate was 17 ± 2 U/mg. In addition we determined the kinetic parameters and cleavage preferences of protease StmPr2.}, language = {en} } @article{GrundmannBauerBieleetal.2019, author = {Grundmann, Jan Thimo and Bauer, Waldemar and Biele, Jens and Boden, Ralf and Ceriotti, Matteo and Cordero, Federico and Dachwald, Bernd and Dumont, Etienne and Grimm, Christian D. and Hercik, David}, title = {Capabilities of Gossamer-1 derived small spacecraft solar sails carrying Mascot-derived nanolanders for in-situ surveying of NEAs}, series = {Acta Astronautica}, volume = {156}, journal = {Acta Astronautica}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0094-5765}, doi = {10.1016/j.actaastro.2018.03.019}, pages = {330 -- 362}, year = {2019}, language = {en} } @article{NamAroraBehbahanietal.2010, author = {Nam, J. and Arora, D. and Behbahani, Mehdi and Probst, M. and Benkowski, R. and Behr, Marek and Pasquali, M.}, title = {New computational method in hemolysis analysis for artificial heart pump}, year = {2010}, language = {en} } @article{UllrichGrottkeRossaintetal.2010, author = {Ullrich, Sebastian and Grottke, Oliver and Rossaint, Rolf and Staat, Manfred and Deserno, Thomas M. and Kuhlen, Torsten}, title = {Virtual Needle Simulation with Haptics for Regional Anaesthesia}, pages = {3 Seiten}, year = {2010}, language = {en} } @article{KaemperBergBegemannetal.1998, author = {K{\"a}mper, Klaus-Peter and Berg, U. and Begemann, M. and Hagemann, B.}, title = {Series production and testing of a micro motor. Serienfertigung und Pr{\"u}fung eines Mikromotors}, series = {Actuator 98 : 6th International Conference on New Actuators ; 17 - 19 June, 1998, Bremen, Germany ; conference proceedings / ed.: Hubert Borgmann ...}, journal = {Actuator 98 : 6th International Conference on New Actuators ; 17 - 19 June, 1998, Bremen, Germany ; conference proceedings / ed.: Hubert Borgmann ...}, publisher = {Messe Bremen}, address = {Bremen}, isbn = {3-933339-00-6}, pages = {552 -- 555}, year = {1998}, language = {en} } @article{BehbahaniWalugaArltetal.2008, author = {Behbahani, Mehdi and Waluga, C. and Arlt, S. and Behr, Marek and Mottaghy, K.}, title = {Computational Analysis of Platelet Aggregation in a Taylor-Couette System}, series = {The International Journal of Artificial Organs. 31 (2008), H. 7}, journal = {The International Journal of Artificial Organs. 31 (2008), H. 7}, isbn = {0391-3988}, pages = {643}, year = {2008}, language = {en} } @article{RibitschKarlBirnerGruenbergeretal.2010, author = {Ribitsch, Doris and Karl, Wolfgang and Birner-Gruenberger, R. and Gruber, K. and Eiteljoerg, I. and Remler, Peter and Wieland, S. and Siegert, Petra and Maurer, Karl-Heinz and Schwab, H.}, title = {C-terminal truncation of a metagenome-derived detergent protease for effective expression in E. coli}, series = {Journal of biotechnology}, volume = {150}, journal = {Journal of biotechnology}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-4863 (E-Journal); 0168-1656 (Print)}, doi = {10.1016/j.jbiotec.2010.09.947}, pages = {408 -- 416}, year = {2010}, abstract = {Recently, a new alkaline protease named HP70 showing highest homology to extracellular serine proteases of Stenotrophomonas maltophilia and Xanthomonas campestris was found in the course of a metagenome screening for detergent proteases (Niehaus et al., submitted for publication). Attempts to efficiently express the enzyme in common expression hosts had failed. This study reports on the realization of overexpression in Escherichia coli after structural modification of HP70. Modelling of HP70 resulted in a two-domain structure, comprising the catalytic domain and a C-terminal domain which includes about 100 amino acids. On the basis of the modelled structure the enzyme was truncated by deletion of most of the C-terminal domain yielding HP70-C477. This structural modification allowed effective expression of active enzyme using E. coli BL21-Gold as the host. Specific activity of HP70-C477 determined with suc-l-Ala-l-Ala-l-Pro-l-Phe-p-nitroanilide as the substrate was 30 ± 5 U/mg compared to 8 ± 1 U/mg of the native enzyme. HP70-C477 was most active at 40 °C and pH 7-11; these conditions are prerequisite for a potential application as detergent enzyme. Determination of kinetic parameters at 40 °C and pH = 9.5 resulted in KM = 0.23 ± 0.01 mM and kcat = 167.5 ± 3.6 s⁻¹. MS-analysis of peptide fragments obtained from incubation of HP70 and HP70-C477 with insulin B indicated that the C-terminal domain influences the cleavage preferences of the enzyme. Washing experiments confirmed the high potential of HP70-C477 as detergent protease.}, language = {en} } @article{RibitschHeumannTrotschaetal.2011, author = {Ribitsch, Doris and Heumann, Sonja and Trotscha, E. and Herrero Acero, E. and Greimel, K. and Leber, R. and Birner-Gruenberger, R. and Deller, S. and Eiteljoerg, I. and Remler, Peter and Weber, Th. and Siegert, Petra and Maurer, Karl-Heinz and Donelli, I. and Freddi, G. and Schwab, H. and Guebitz, G. M.}, title = {Hydrolysis of polyethyleneterephthalate by p-nitrobenzylesterase from Bacillus subtilis}, series = {Biotechnology progress}, volume = {Vol. 27}, journal = {Biotechnology progress}, number = {Iss. 4}, publisher = {Wiley}, address = {Hoboken}, issn = {1520-6033 (E-Journal); 8756-7938 (Print)}, pages = {951 -- 960}, year = {2011}, language = {en} } @article{Timme2010, author = {Timme, Michael}, title = {Mietschuldenfreiheitsbescheinigung durch den bisherigen Vermieter?}, series = {MDR Monatsschrift f{\"u}r Deutsches Recht}, volume = {64}, journal = {MDR Monatsschrift f{\"u}r Deutsches Recht}, number = {2}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, issn = {0340-1812}, doi = {10.9785/ovs-mdtr-2010-60}, pages = {60 -- 61}, year = {2010}, abstract = {Der VIII. Zivilsenat des BGH hat entschieden, dass ein Mieter von seinem ehemaligen Vermieter keine „Mietschuldenfreiheitsbescheinigung'' verlangen kann, die {\"u}ber eine Quittung f{\"u}r die erhaltenen Mietzahlungen hinausgeht. Der folgende Beitrag untersucht die Konsequenzen der aktuellen Entscheidung.}, language = {de} } @article{ProbstBehbahaniBorrmannetal.2010, author = {Probst, M. and Behbahani, Mehdi and Borrmann, E. and Elgeti, S. and Nicolai, M. and Behr, Marek}, title = {Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices}, year = {2010}, language = {en} } @article{TimmeHuelk2010, author = {Timme, Michael and H{\"u}lk, Fabian}, title = {Schriftform bei Mietvertrag mit einer Aktiengesellschaft}, series = {Neue Zeitschrift f{\"u}r Gesellschaftsrecht (NZG)}, volume = {13}, journal = {Neue Zeitschrift f{\"u}r Gesellschaftsrecht (NZG)}, number = {5}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {1434-9272}, pages = {177 -- 178}, year = {2010}, language = {de} } @article{EschSalberKemperetal.2001, author = {Esch, Thomas and Salber, Wolfgang and Kemper, Hans and Staay, F. van der}, title = {Der elektromechanische Ventiltrieb - Systembaustein f{\"u}r zuk{\"u}nftige Antriebskonzepte, Teil 2.}, series = {Motortechnische Zeitschrift (MTZ).}, volume = {62}, journal = {Motortechnische Zeitschrift (MTZ).}, number = {1}, publisher = {Springer Nature}, address = {Basel}, issn = {0024-8525}, doi = {10.1007/bf03227081}, pages = {44 -- 55}, year = {2001}, language = {de} } @article{EschSalberWoltersetal.2002, author = {Esch, Thomas and Salber, Wolfgang and Wolters, Peter and Geiger, Jos{\´e} and Dilthey, Jochen}, title = {Synergies of variable valve actuation and direct injection}, series = {Direct injection SI engine technology 2002 : [SAE 2002 world congress, Detroit, Michigan, USA, March 4 - 7, 2002].}, journal = {Direct injection SI engine technology 2002 : [SAE 2002 world congress, Detroit, Michigan, USA, March 4 - 7, 2002].}, publisher = {Society of Automotive Engineers}, address = {Warrendale, Pa}, isbn = {0-7680-0961-8}, pages = {45 -- 53}, year = {2002}, language = {en} }