@inproceedings{MuellerHueben2008, author = {M{\"u}ller, Karsten and H{\"u}ben, Susanne}, title = {From rehabilitation strategy up to formation of lots : implementation of a computer-aided decision support system}, series = {11th International Conference on Urban Drainage, Edinburgh, Scotland, UK, 31st August to 5th September 2008}, booktitle = {11th International Conference on Urban Drainage, Edinburgh, Scotland, UK, 31st August to 5th September 2008}, pages = {12 S. : graph. Darst.}, year = {2008}, language = {en} } @inproceedings{MuellerFischer2009, author = {M{\"u}ller, Karsten and Fischer, B.}, title = {Objective condition assessment of sewer systems}, series = {Strategic asset management of water supply and wastewater infrastructures : invited papers from the 2nd IWA Leading Edge Conference on Strategic Asset Management (LESAM), Lisbon, October [17 - 19] 2007 / ed. by Helene Alegre and Maria do C{\´e}u Almeida}, booktitle = {Strategic asset management of water supply and wastewater infrastructures : invited papers from the 2nd IWA Leading Edge Conference on Strategic Asset Management (LESAM), Lisbon, October [17 - 19] 2007 / ed. by Helene Alegre and Maria do C{\´e}u Almeida}, publisher = {IWA Publ.}, address = {London}, isbn = {9781843391869}, pages = {521 -- 534}, year = {2009}, language = {en} } @article{MuellerBeckersMussmannetal.2018, author = {M{\"u}ller, Janina and Beckers, Mario and Mußmann, Nina and Bongaerts, Johannes and B{\"u}chs, Jochen}, title = {Elucidation of auxotrophic deficiencies of Bacillus pumilus DSM 18097 to develop a defined minimal medium}, series = {Microbial Cell Factories}, volume = {17}, journal = {Microbial Cell Factories}, number = {1}, publisher = {BioMed Central}, issn = {1475-2859}, doi = {10.1186/s12934-018-0956-1}, pages = {Article No. 106}, year = {2018}, abstract = {Background Culture media containing complex compounds like yeast extract or peptone show numerous disadvantages. The chemical composition of the complex compounds is prone to significant variations from batch to batch and quality control is difficult. Therefore, the use of chemically defined media receives more and more attention in commercial fermentations. This concept results in better reproducibility, it simplifies downstream processing of secreted products and enable rapid scale-up. Culturing bacteria with unknown auxotrophies in chemically defined media is challenging and often not possible without an extensive trial-and-error approach. In this study, a respiration activity monitoring system for shake flasks and its recent version for microtiter plates were used to clarify unknown auxotrophic deficiencies in the model organism Bacillus pumilus DSM 18097. Results Bacillus pumilus DSM 18097 was unable to grow in a mineral medium without the addition of complex compounds. Therefore, a rich chemically defined minimal medium was tested containing basically all vitamins, amino acids and nucleobases, which are essential ingredients of complex components. The strain was successfully cultivated in this medium. By monitoring of the respiration activity, nutrients were supplemented to and omitted from the rich chemically defined medium in a rational way, thus enabling a systematic and fast determination of the auxotrophic deficiencies. Experiments have shown that the investigated strain requires amino acids, especially cysteine or histidine and the vitamin biotin for growth. Conclusions The introduced method allows an efficient and rapid identification of unknown auxotrophic deficiencies and can be used to develop a simple chemically defined tailor-made medium. B. pumilus DSM 18097 was chosen as a model organism to demonstrate the method. However, the method is generally suitable for a wide range of microorganisms. By combining a systematic combinatorial approach based on monitoring the respiration activity with cultivation in microtiter plates, high throughput experiments with high information content can be conducted. This approach facilitates media development, strain characterization and cultivation of fastidious microorganisms in chemically defined minimal media while simultaneously reducing the experimental effort.}, language = {en} } @article{MuehlBinneboeselKlingeetal.2008, author = {M{\"u}hl, Thomas and Binneb{\"o}sel, Marcel and Klinge, Uwe and Goedderz, Thomas}, title = {New objective measurement to characterize the porosity of textile implants}, series = {Journal of Biomedical Materials Research Part B: Applied Biomaterials. 84B (2008), H. 1}, journal = {Journal of Biomedical Materials Research Part B: Applied Biomaterials. 84B (2008), H. 1}, isbn = {1552-4981}, pages = {176 -- 183}, year = {2008}, language = {en} } @misc{MoehringWulfhorstCapitainetal.2016, author = {M{\"o}hring, S. and Wulfhorst, Helene and Capitain, Charlotte and Roth, J. and Tippk{\"o}tter, Nils}, title = {Fractioning of lignocellulosic biomass: Scale-down and automation of thermal pretreatment for parameter optimization}, series = {Chemie Ingenieur Technik}, volume = {88}, journal = {Chemie Ingenieur Technik}, number = {9}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0009-286X}, doi = {10.1002/cite.201650288}, pages = {1229}, year = {2016}, abstract = {In order to efficiently convert lignocellulose, it is often necessary to conduct a pretreatment. The biomass considered in this study typically comprises of agricultural and horticultural residues, as well as beechwood. A very environmentally friendly method, namely, fungal pretreatment using white-rot fungi, leads to an enhanced enzymatic hydrolysis. In contrast to other processes presented, the energy input is extremely low. However, the fungal growth on the lignocellulosic substrates takes several weeks at least in order to be effective. Thus, the reduction of chemicals and energy for thermal processing is a target of our current research. Liquid hot water (LHW) and solvent-based pretreatment (OrganoSolv) require more complex equipment, as they depend on high temperatures (160 - 180 °C) and enhanced pressure (up to 20 bar). However, they prove to be promising processes in regard to the fractioning of lignocellulose. For optimal lignin recovery the parameters differ from those established in cellulose extraction. A novel screening system scaled down to a reaction volume of 100 mL has been developed and successfully tested for this purpose.}, language = {en} } @inproceedings{MoehringWulfhorstRothetal.2016, author = {M{\"o}hring, S. and Wulfhorst, H. and Roth, J. and Tippk{\"o}tter, Nils}, title = {Pretreatment strategies for lignocellulosic biomass}, series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany}, booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany}, publisher = {DECHEMA}, address = {Frankfurt am Main}, pages = {131}, year = {2016}, language = {en} } @inproceedings{MoehrenBergmannJanseretal.2023, author = {M{\"o}hren, Felix and Bergmann, Ole and Janser, Frank and Braun, Carsten}, title = {On the determination of harmonic propeller loads}, series = {AIAA SCITECH 2023 Forum}, booktitle = {AIAA SCITECH 2023 Forum}, publisher = {AIAA}, doi = {10.2514/6.2023-2404}, pages = {12 Seiten}, year = {2023}, abstract = {Dynamic loads significantly impact the structural design of propeller blades due to fatigue and static strength. Since propellers are elastic structures, deformations and aerodynamic loads are coupled. In the past, propeller manufacturers established procedures to determine unsteady aerodynamic loads and the structural response with analytical steady-state calculations. According to the approach, aeroelastic coupling primarily consists of torsional deformations. They neglect bending deformations, deformation velocities, and inertia terms. This paper validates the assumptions above for a General Aviation propeller and a lift propeller for urban air mobility or large cargo drones. Fully coupled reduced-order simulations determine the dynamic loads in the time domain. A quasi-steady blade element momentum approach transfers loads to one-dimensional finite beam elements. The simulation results are in relatively good agreement with the analytical method for the General Aviation propeller but show increasing errors for the slender lift propeller. The analytical approach is modified to consider the induced velocities. Still, inertia and velocity proportional terms play a significant role for the lift propeller due to increased elasticity. The assumption that only torsional deformations significantly impact the dynamic loads of propellers is not valid. Adequate determination of dynamic loads of such designs requires coupled aeroelastic simulations or advanced analytical procedures.}, language = {en} } @article{MykoniouButenwegHoltschoppenetal.2016, author = {Mykoniou, Konstantin and Butenweg, Christoph and Holtschoppen, Britta and Klinkel, Sven}, title = {Seismic response analysis of adjacent liquid-storage tanks}, series = {Earthquake engineering and structural dynamics}, volume = {45}, journal = {Earthquake engineering and structural dynamics}, number = {11}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1096-9845 (E-Journal); 0098-8847 (Print)}, doi = {10.1002/eqe.2726}, pages = {1779 -- 1796}, year = {2016}, abstract = {A refined substructure technique in the frequency domain is developed, which permits consideration of the interaction effects among adjacent containers through the supporting deformable soil medium. The tank-liquid systems are represented by means of mechanical models, whereas discrete springs and dashpots stand for the soil beneath the foundations. The proposed model is employed to assess the responses of adjacent circular, cylindrical tanks for harmonic and seismic excitations over wide range of tank proportions and soil conditions. The influence of the number, spatial arrangement of the containers and their distance on the overall system's behavior is addressed. The results indicate that the cross-interaction effects can substantially alter the impulsive components of response of each individual element in a tank farm. The degree of this impact is primarily controlled by the tank proportions and the proximity of the predominant natural frequencies of the shell-liquid-soil systems and the input seismic motion. The group effects should be not a priori disregarded, unless the tanks are founded on shallow soil deposit overlying very stiff material or bedrock.}, language = {en} } @article{MyburghJacobszBothaLeRouxKotliaretal.2024, author = {Myburgh-Jacobsz, Catharina Elizabeth and Botha-Le Roux, Shani and Kotliar, Konstantin and Wentzel, Annemarie and Jacobs, Adriaan and De Boever, Patrick and Goswami, Nandu and Strijdom, Hans and Smith, Wayne}, title = {Retinal vessel functional responses in South Africans living with and without HIV: the EndoAfrica-NWU study}, series = {Microcirculation}, journal = {Microcirculation}, number = {Early View}, publisher = {Wiley}, address = {Malden, MA}, issn = {1073-9688 (Print)}, doi = {10.1111/micc.12878}, pages = {11 Seiten}, year = {2024}, language = {en} } @article{MusholtSchoendorfPfuetzneretal.2009, author = {Musholt, Petra B. and Sch{\"o}ndorf, Thomas and Pf{\"u}tzner, Andreas and Hohberg, Cloth and Kleine, Iris and Fuchs, Winfried and Hehenwarter, Silvia and Dikta, Gerhard and Kerschgens, Benedikt and Forst, Thomas}, title = {Combined Pioglitazone and Metformin Treatment Maintains the Beneficial Effect of Short-Term Insulin Infusion in Patients with Type 2 Diabetes: Results from a Pilot Study}, series = {Journal of Diabetes Science and Technology. 3 (2009), H. 6}, journal = {Journal of Diabetes Science and Technology. 3 (2009), H. 6}, publisher = {Sage Publishing}, address = {London}, isbn = {1932-2968}, pages = {1442 -- 1450}, year = {2009}, language = {en} } @article{MuschallikMolinnusJablonskietal.2020, author = {Muschallik, Lukas and Molinnus, Denise and Jablonski, Melanie and Kipp, Carina Ronja and Bongaerts, Johannes and Pohl, Martina and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Selmer, Thorsten and Siegert, Petra}, title = {Synthesis of α-hydroxy ketones and vicinal (R, R)-diols by Bacillus clausii DSM 8716ᵀ butanediol dehydrogenase}, series = {RSC Advances}, volume = {10}, journal = {RSC Advances}, publisher = {Royal Society of Chemistry (RSC)}, address = {Cambridge}, issn = {2046-2069}, doi = {10.1039/D0RA02066D}, pages = {12206 -- 12216}, year = {2020}, abstract = {α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716ᵀ (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn²⁺ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated.}, language = {en} } @article{MuschallikMolinnusBongaertsetal.2017, author = {Muschallik, Lukas and Molinnus, Denise and Bongaerts, Johannes and Pohl, Martina and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Siegert, Petra and Selmer, Thorsten}, title = {(R,R)-Butane-2,3-diol Dehydrogenase from Bacillus clausii DSM 8716T: Cloning and Expression of the bdhA-Gene, and Initial Characterization of Enzyme}, series = {Journal of Biotechnology}, volume = {258}, journal = {Journal of Biotechnology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-1656}, doi = {10.1016/j.jbiotec.2017.07.020}, pages = {41 -- 50}, year = {2017}, abstract = {The gene encoding a putative (R,R)-butane-2,3-diol dehydrogenase (bdhA) from Bacillus clausii DSM 8716T was isolated, sequenced and expressed in Escherichia coli. The amino acid sequence of the encoded protein is only distantly related to previously studied enzymes (identity 33-43\%) and exhibited some uncharted peculiarities. An N-terminally StrepII-tagged enzyme variant was purified and initially characterized. The isolated enzyme catalyzed the (R)-specific oxidation of (R,R)- and meso-butane-2,3-diol to (R)- and (S)-acetoin with specific activities of 12 U/mg and 23 U/mg, respectively. Likewise, racemic acetoin was reduced with a specific activity of up to 115 U/mg yielding a mixture of (R,R)- and meso-butane-2,3-diol, while the enzyme reduced butane-2,3-dione (Vmax 74 U/mg) solely to (R,R)-butane-2,3-diol via (R)-acetoin. For these reactions only activity with the co-substrates NADH/NAD+ was observed. The enzyme accepted a selection of vicinal diketones, α-hydroxy ketones and vicinal diols as alternative substrates. Although the physiological function of the enzyme in B. clausii remains elusive, the data presented herein clearly demonstrates that the encoded enzyme is a genuine (R,R)-butane-2,3-diol dehydrogenase with potential for applications in biocatalysis and sensor development.}, language = {en} } @article{MuschallikKippReckeretal.2020, author = {Muschallik, Lukas and Kipp, Carina Ronja and Recker, Inga and Bongaerts, Johannes and Pohl, Martina and Gelissen, Melanie and Sch{\"o}ning, Michael Josef and Selmer, Thorsten and Siegert, Petra}, title = {Synthesis of α-hydroxy ketones and vicinal diols with the Bacillus licheniformis DSM 13T butane-2, 3-diol dehydrogenase}, series = {Journal of Biotechnology}, volume = {202}, journal = {Journal of Biotechnology}, number = {Vol. 324}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {2590-1559}, doi = {10.1016/j.jbiotec.2020.09.016}, pages = {61 -- 70}, year = {2020}, abstract = {The enantioselective synthesis of α-hydroxy ketones and vicinal diols is an intriguing field because of the broad applicability of these molecules. Although, butandiol dehydrogenases are known to play a key role in the production of 2,3-butandiol, their potential as biocatalysts is still not well studied. Here, we investigate the biocatalytic properties of the meso-butanediol dehydrogenase from Bacillus licheniformis DSM 13T (BlBDH). The encoding gene was cloned with an N-terminal StrepII-tag and recombinantly overexpressed in E. coli. BlBDH is highly active towards several non-physiological diketones and α-hydroxyketones with varying aliphatic chain lengths or even containing phenyl moieties. By adjusting the reaction parameters in biotransformations the formation of either the α-hydroxyketone intermediate or the diol can be controlled.}, language = {en} } @article{MuribYeapMartensetal.2014, author = {Murib, Mohammed Sharif and Yeap, Weng-Siang and Martens, Daan and Bienstman, Peter and Ceuninck, Ward de and Grinsven, Bart van and Sch{\"o}ning, Michael Josef and Michiels, Luc and Haenen, Ken and Ameloot, Marcel and Serpeng{\"u}zel, Ali and Wagner, Patrick}, title = {Photonic detection and characterization of DNA using sapphire microspheres}, series = {Journal of biomedical optics}, volume = {19}, journal = {Journal of biomedical optics}, number = {9}, publisher = {SPIE}, address = {Bellingham}, issn = {1560-2281 (E-Journal); 1083-3668 (Print)}, doi = {10.1117/1.JBO.19.9.097006}, pages = {097006}, year = {2014}, abstract = {A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants.}, language = {en} } @article{MuribYeapMartensetal.2015, author = {Murib, Mohammed Sharif and Yeap, Weng Siang and Martens, Daan and Liu, Xianjie and Bienstman, Peter and Fahlman, M. and Sch{\"o}ning, Michael Josef and Michiels, Luc and Haenen, Ken and Serpeng{\"u}zel, Ali and Wagner, Patrick}, title = {Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands}, series = {Sensors and actuators A: Physical}, volume = {222}, journal = {Sensors and actuators A: Physical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3069 (E-Journal); 0924-4247 (Print)}, doi = {10.1016/j.sna.2014.11.024}, pages = {212 -- 219}, year = {2015}, abstract = {In this study we show an optical biosensor concept, based on elastic light scattering from sapphire microspheres. Transmitted and elastic scattering intensity of the microspheres (radius 500 μm, refractive index 1.77) on an optical fiber half coupler is analyzed at 1510 nm. The 0.43 nm angular mode spacing of the resonances is comparable to the angular mode spacing value estimated using the optical size of the microsphere. The spectral linewidths of the resonances are in the order of 0.01 nm, which corresponds to quality factors of approximately 105. A polydopamine layer is used as a functionalizing agent on sapphire microspherical resonators in view of biosensor implementation. The varying layer thickness on the microsphere is determined as a function of the resonance wavelength shift. It is shown that polymer functionalization has a minor effect on the quality factor. This is a promising step toward the development of an optical biosensor.}, language = {en} } @article{MuribYeapEurlingsetal.2016, author = {Murib, Mohammed Sharif and Yeap, Weng Siang and Eurlings, Y. and Grinsven, Bart van and Boyen, Hans-Gerd and Conings, Bert and Michiels, Luc and Ameloot, Marcel and Carleer, R. and Warmer, Johannes and Kaul, Peter Michael and Haenen, Ken and Sch{\"o}ning, Michael Josef and de Ceuninck, Ward A. and Wagner, Patrick Hermann}, title = {Heat-transfer based characterization of DNA on synthetic sapphire chips}, series = {Sensors and Actuators B: Chemical}, volume = {230}, journal = {Sensors and Actuators B: Chemical}, number = {230}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.02.027}, pages = {260 -- 271}, year = {2016}, abstract = {In this study, we show that synthetic sapphire (Al₂O₃), an established implant material, can also serve as a platform material for biosensors comparable to nanocrystalline diamond. Sapphire chips, beads, and powder were first modified with (3-aminopropyl) triethoxysilane (APTES), followed by succinic anhydride (SA), and finally single-stranded probe DNA was EDC coupled to the functionalized layer. The presence of the APTES-SA layer on sapphire powders was confirmed by thermogravimetric analyis and Fourier-transform infrared spectroscopy. Using planar sapphire chips as substrates and X-ray photoelectron spectroscopy (XPS) as surface-sensitive tool, the sequence of individual layers was analyzed with respect to their chemical state, enabling the quantification of areal densities of the involved molecular units. Fluorescence microscopy was used to demonstrate the hybridization of fluorescently tagged target DNA to the probe DNA, including denaturation- and re-hybridization experiments. Due to its high thermal conductivity, synthetic sapphire is especially suitable as a chip material for the heat-transfer method, which was employed to distinguish complementary- and non-complementary DNA duplexes containing single-nucleotide polymorphisms. These results indicate that it is possible to detect mutations electronically with a chemically resilient and electrically insulating chip material.}, language = {en} } @article{MuribTranCeunincketal.2012, author = {Murib, Mohammed S. and Tran, Anh Quang and Ceuninck, Ward de and Sch{\"o}ning, Michael Josef and Nesladek, Milos and Serpeng{\"u}zel, Ali and Wagner, Patrick}, title = {Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres}, series = {Physica Status Solidi A}, volume = {209}, journal = {Physica Status Solidi A}, number = {9}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201100795}, pages = {1804 -- 1810}, year = {2012}, abstract = {Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection.}, language = {en} } @article{MuribGrinsvenGrietenetal.2013, author = {Murib, M. S. and Grinsven, B. van and Grieten, L. and Janssens, S. D. and Vermeeren, V. and Eersels, K. and Broeders, J. and Ameloot, Marcel and Michiels, L. and Ceuninck, W. De and Haenen, K. and Sch{\"o}ning, Michael Josef and Wagner, Patrick}, title = {Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates}, series = {Physica Status Solidi (A). Vol. 210 (2013), iss. 5}, journal = {Physica Status Solidi (A). Vol. 210 (2013), iss. 5}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {0031-8965}, pages = {911 -- 917}, year = {2013}, language = {en} } @inproceedings{MulsowHuelsenGuetzlaffetal.2023, author = {Mulsow, Niklas A. and H{\"u}lsen, Benjamin and G{\"u}tzlaff, Joel and Spies, Leon and Bresser, Andreas and Dabrowski, Adam and Czupalla, Markus and Kirchner, Frank}, title = {Concept and design of an autonomous micro rover for long term lunar exploration}, series = {Proceedings of the 74th International Astronautical Congress}, booktitle = {Proceedings of the 74th International Astronautical Congress}, publisher = {dfki}, address = {Saarbr{\"u}cken}, pages = {13 Seiten}, year = {2023}, abstract = {Research on robotic lunar exploration has seen a broad revival, especially since the Google Lunar X-Prize increasingly brought private endeavors into play. This development is supported by national agencies with the aim of enabling long-term lunar infrastructure for in-situ operations and the establishment of a moon village. One challenge for effective exploration missions is developing a compact and lightweight robotic rover to reduce launch costs and open the possibility for secondary payload options. Existing micro rovers for exploration missions are clearly limited by their design for one day of sunlight and their low level of autonomy. For expanding the potential mission applications and range of use, an extension of lifetime could be reached by surviving the lunar night and providing a higher level of autonomy. To address this objective, the paper presents a system design concept for a lightweight micro rover with long-term mission duration capabilities, derived from a multi-day lunar mission scenario at equatorial regions. Technical solution approaches are described, analyzed, and evaluated, with emphasis put on the harmonization of hardware selection due to a strictly limited budget in dimensions and power.}, language = {en} } @article{MulhernBialonskiKantz2015, author = {Mulhern, Colm and Bialonski, Stephan and Kantz, Holger}, title = {Extreme events due to localization of energy}, series = {Physical Review E}, volume = {91}, journal = {Physical Review E}, number = {1}, issn = {2470-0053}, doi = {10.1103/PhysRevE.91.012918}, pages = {012918}, year = {2015}, language = {en} } @article{MukherjeeRamazaniYangetal.2011, author = {Mukherjee, Krishnendu and Ramazani, Ali and Yang, Li and Prahl, Ulrich and Bleck, Wolfgang and Reisgen, Uwe and Schleser, Markus and Abdurakhmanov, Aydemir}, title = {Characterization of gas metal arc welded hot rolled DP600 steel}, series = {Steel research international}, volume = {Vol. 82}, journal = {Steel research international}, number = {Iss. 12}, publisher = {Wiley}, address = {Weinheim}, issn = {1869-344X (E-Book); 1611-3683 (Print)}, pages = {1408 -- 1416}, year = {2011}, language = {en} } @article{MukherjeePrahlBlecketal.2010, author = {Mukherjee, Krishnendu and Prahl, Ulrich and Bleck, Wolfgang and Reisgen, Uwe and Schleser, Markus and Abdurakhmanov, Aydemir}, title = {Characterization and modelling techniques for gas metal arc welding of DP 600 sheet steels}, series = {Materialwissenschaft und Werkstofftechnik}, volume = {41}, journal = {Materialwissenschaft und Werkstofftechnik}, number = {11}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4052}, doi = {10.1002/mawe.201000692}, pages = {972 -- 983}, year = {2010}, abstract = {The objectives of the present work are to characterize the Gas Metal Arc Welding process of DP 600 sheet steel and to summarize the modelling techniques. The time-temperature evolution during the welding cycle was measured experimentally and modelled with the softwaretool SimWeld. To model the phase transformations during the welding cycle dilatometer tests were done to quantify the parameters for phase field modelling by MICRESS®. The important input parameters are interface mobility, nucleation density, etc. A contribution was made to include austenite to bainite transformation in MICRESS®. This is useful to predict the microstructure in the fast cooling segments. The phase transformation model is capable to predict the microstructure along the heating and cooling cycles of welding. Tensile tests have shown the evidence of failure at the heat affected zone, which has the ferrite-tempered martensite microstructure.}, language = {en} } @incollection{MufflerTippkoetterUlber2010, author = {Muffler, Kai and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Chemical feedstocks and fine chemicals from other substrates}, series = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)}, booktitle = {Handbook of hydrocarbon and lipid microbiology. Volume 4: Consequences of microbial interactions with hydrocarbons, oils and lipids. - (Springer reference)}, editor = {Timmis, Kenneth N.}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-540-77588-1}, doi = {10.1007\%2F978-3-540-77587-4_214}, pages = {2891 -- 2902}, year = {2010}, language = {en} } @incollection{MufflerPothSiekeretal.2011, author = {Muffler, Kai and Poth, Sabastian and Sieker, Tim and Tippk{\"o}tter, Nils and Ulber, Roland and Sell, Dieter}, title = {Bio-feedstocks}, series = {Comprehensive biotechnology : principles and practices in industry, agcriculture, medicine and the environment. Volume 2: Engineering fundamentals of biotechnology}, booktitle = {Comprehensive biotechnology : principles and practices in industry, agcriculture, medicine and the environment. Volume 2: Engineering fundamentals of biotechnology}, editor = {Moo-Young, Murray}, edition = {2. edition}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-444-53352-4}, doi = {10.1016/B978-0-08-088504-9.00088-X}, pages = {93 -- 101}, year = {2011}, language = {en} } @article{MuesgenanntKoersPrevostPaulssenetal.2023, author = {Mues genannt Koers, Lucas and Prevost, David and Paulßen, Elisabeth and Hoehr, Cornelia}, title = {Density reduction effects on the production of [11C]CO2 in Nb-body targets on a medical cyclotron}, volume = {199}, number = {Art. 110911}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.apradiso.2023.110911}, year = {2023}, abstract = {Medical isotope production of 11C is commonly performed in gaseous targets. The power deposition of the proton beam during the irradiation decreases the target density due to thermodynamic mixing and can cause an increase of penetration depth and divergence of the proton beam. In order to investigate the difference how the target-body length influences the operation conditions and the production yield, a 12 cm and a 22 cm Nb-target body containing N2/O2 gas were irradiated using a 13 MeV proton cyclotron. It was found that the density reduction has a large influence on the pressure rise during irradiation and the achievable radioactive yield. The saturation activity of [11C]CO2 for the long target (0.083 Ci/μA) is about 10\% higher than in the short target geometry (0.075 Ci/μA).}, language = {en} } @article{MuesgenanntKoersMcNeilRadchenkoetal.2023, author = {Mues genannt Koers, Lucas and McNeil, S. W. and Radchenko, V. and Paulßen, Elisabeth and Hoehr, Cornelia}, title = {Production of Co-58m in a siphon-style liquid target on a medical cyclotron}, volume = {195}, number = {Art. 110734}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0969-8043}, doi = {10.1016/j.apradiso.2023.110734}, year = {2023}, abstract = {We present the production of 58mCo on a small, 13 MeV medical cyclotron utilizing a siphon style liquid target system. Different concentrated iron(III)-nitrate solutions of natural isotopic distribution were irradiated at varying initial pressures and subsequently separated by solid phase extraction chromatography. The radio cobalt (58m/gCo and 56Co) was successfully produced with saturation activities of (0.35 ± 0.03) MBq μA-1 for 58mCo with a separation recovery of (75 ± 2) \% of cobalt after one separation step utilizing LN-resin.}, language = {en} } @article{MuellerSeginWeigandetal.2022, author = {Mueller, Tobias and Segin, Alexander and Weigand, Christoph and Schmitt, Robert H.}, title = {Feature selection for measurement models}, series = {International journal of quality \& reliability management}, journal = {International journal of quality \& reliability management}, number = {Vol. ahead-of-print, No. ahead-of-print.}, publisher = {Emerald Group Publishing Limited}, address = {Bingley}, issn = {0265-671X}, doi = {10.1108/IJQRM-07-2021-0245}, year = {2022}, abstract = {Purpose In the determination of the measurement uncertainty, the GUM procedure requires the building of a measurement model that establishes a functional relationship between the measurand and all influencing quantities. Since the effort of modelling as well as quantifying the measurement uncertainties depend on the number of influencing quantities considered, the aim of this study is to determine relevant influencing quantities and to remove irrelevant ones from the dataset. Design/methodology/approach In this work, it was investigated whether the effort of modelling for the determination of measurement uncertainty can be reduced by the use of feature selection (FS) methods. For this purpose, 9 different FS methods were tested on 16 artificial test datasets, whose properties (number of data points, number of features, complexity, features with low influence and redundant features) were varied via a design of experiments. Findings Based on a success metric, the stability, universality and complexity of the method, two FS methods could be identified that reliably identify relevant and irrelevant influencing quantities for a measurement model. Originality/value For the first time, FS methods were applied to datasets with properties of classical measurement processes. The simulation-based results serve as a basis for further research in the field of FS for measurement models. The identified algorithms will be applied to real measurement processes in the future.}, language = {en} } @article{MuckWangJacobsetal.2004, author = {Muck, A. and Wang, J. and Jacobs, M. and Chen, G. and Chatrathi, M. P. and Jurka, V. and Vyborny, Z. and Spillmann, S. D. and Sridharan, G. and Sch{\"o}ning, Michael Josef}, title = {Fabrication of poly(methyl methacrylate) microfluidic chips by atmospheric molding}, series = {Analytical Chemistry. 76 (2004), H. 8}, journal = {Analytical Chemistry. 76 (2004), H. 8}, isbn = {0003-2700}, pages = {2290 -- 2297}, year = {2004}, language = {en} } @article{MourzinaSchoeningSchubertetal.2000, author = {Mourzina, Yu.G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H.}, title = {Thin film microsensors for fast heavy metal analysis}, series = {Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]}, journal = {Proceedings : Copenhagen, Denmark, 27 - 30 August 2000 / [ed.: R. de Reus ...]}, publisher = {MIC, Mikroelektronik Centret}, address = {Lyngby, Denmark}, isbn = {87-89935-50-0}, pages = {839 -- 840}, year = {2000}, language = {en} } @article{MourzinaSchubertZanderetal.2001, author = {Mourzina, Yu. G. and Schubert, J and Zander, W. and Legin, A. and Vlasov, Y. G. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {Development of multisensor systems based on chalcogenide thin film chemical sensors for the simultaneous multicomponent analysis of metal ions in complex solutions}, series = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz}, journal = {Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz}, publisher = {Elsevier [u.a.]}, address = {Amsterdam [u.a.]}, isbn = {0-08-044014-2}, pages = {251 -- 263}, year = {2001}, language = {en} } @article{MourzinaSchoeningSchubertetal.2000, author = {Mourzina, Y.G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and Legin, A. V. and Vlasov, Y. G. and Kordos, P. and L{\"u}th, H.}, title = {A new thin film Pb microsensor based on chalcogenide glasses}, series = {Sensors and Actuators B. 71 (2000), H. 1-2}, journal = {Sensors and Actuators B. 71 (2000), H. 1-2}, isbn = {0925-4005}, pages = {13 -- 18}, year = {2000}, language = {en} } @article{MourzinaYoshinobuErmelenkoetal.2002, author = {Mourzina, Y. and Yoshinobu, T. and Ermelenko, Y. and Furuichi, K. and Vlasov, Y. and Sch{\"o}ning, Michael Josef and Iwasaki, H.}, title = {Technology of photocurable membranes for ion sensors based on laser scanned semiconductor transducer (LSST)}, series = {Book of abstracts / ed. by J. Saneistr.}, journal = {Book of abstracts / ed. by J. Saneistr.}, publisher = {Czech Technical University, Faculty of Electrical Engineering, Department of Measurement}, address = {Prague}, isbn = {80-01-02576-4}, pages = {254 -- 257}, year = {2002}, language = {en} } @article{MourzinaMaiPoghossianetal.2003, author = {Mourzina, Y. and Mai, T. and Poghossian, Arshak and Ermolenko, Y. and Yoshinobu, T. and Vlasov, Y. and Iwasaki, H. and Sch{\"o}ning, Michael Josef}, title = {K+-selective field-effect sensors as transducers for bioelectronic applications}, series = {Electrochimica Acta. 48 (2003), H. 20-22}, journal = {Electrochimica Acta. 48 (2003), H. 20-22}, isbn = {0013-4686}, pages = {3333 -- 3339}, year = {2003}, language = {en} } @article{MourzinaYoshinobuSchubertetal.2001, author = {Mourzina, Y. G. and Yoshinobu, T. and Schubert, J. and L{\"u}th, H. and Iwasaki, H. and Sch{\"o}ning, Michael Josef}, title = {Ion-selective lightaddressable potentiometric sensor (LAPS) with chalcogenide thin film by pulsed laser deposition}, series = {Sensors and Actuators B. 80 (2001), H. 2}, journal = {Sensors and Actuators B. 80 (2001), H. 2}, isbn = {0925-4005}, pages = {136 -- 140}, year = {2001}, language = {en} } @article{MourzinaSchoeningSchubertetal.2001, author = {Mourzina, Y. G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and Legin, A. V. and Vlasov, Y. G. and L{\"u}th, H.}, title = {Copper, cadmium and thallium thin film sensors based on chalcogenide glasses}, series = {Analytica Chimica Acta. 433 (2001)}, journal = {Analytica Chimica Acta. 433 (2001)}, isbn = {0378-4304}, pages = {103 -- 110}, year = {2001}, language = {en} } @article{MourzinaLeginVlasovetal.2001, author = {Mourzina, Y. G. and Legin, A. and Vlasov, Y. G. and Sch{\"o}ning, Michael Josef and Schubert, J. and Zander, W. and L{\"u}th, H.}, title = {Thin film chemical sensors based on chalcogenide glasses for „electronic tongue" applications}, series = {Sensor 2001 : 10th international conference, May 8 - 10, 2001, Exhibition Centre Nuremberg, Germany ; proceedings}, journal = {Sensor 2001 : 10th international conference, May 8 - 10, 2001, Exhibition Centre Nuremberg, Germany ; proceedings}, publisher = {AMA Service}, address = {Wunstorf}, pages = {137 -- 141}, year = {2001}, language = {en} } @article{MourzinaErmelenkoYoshinobuetal.2003, author = {Mourzina, Y. G. and Ermelenko, Y. E. and Yoshinobu, T. and Vlasov, Y. and Iwasaki, H. and Sch{\"o}ning, Michael Josef}, title = {Anionselective light-addressable potentiometric sensors (LAPS) for the determination of nitrate and suphate ions}, series = {Sensors and Actuators B. 91 (2003), H. 1-3}, journal = {Sensors and Actuators B. 91 (2003), H. 1-3}, isbn = {0925-4005}, pages = {32 -- 38}, year = {2003}, language = {en} } @article{MourzinaYoshinobuErmolenkoetal.2004, author = {Mourzina, Ioulia G. and Yoshinobu, Tatsuo and Ermolenko, Yuri E. and Vlasov, Yuri G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.}, title = {Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of lightaddressable potentiometric sensors}, series = {Microchimica Acta. 144 (2004), H. 1-3}, journal = {Microchimica Acta. 144 (2004), H. 1-3}, isbn = {0026-3672}, pages = {41 -- 50}, year = {2004}, language = {en} } @article{MourzinaYoshinobuErmolenkoetal.2004, author = {Mourzina, I.G. and Yoshinobu, T. and Ermolenko, Y.E. and Vlasov, Y. G. and Sch{\"o}ning, Michael Josef and Iwasaki, H.}, title = {Immobilization of urease and cholinesterase on the surface of semiconductor transducer for the development of light-addressable potentiometric sensors}, series = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors}, journal = {Technical digest of the 10th International Meeting on Chemical Sensors, July 11 - 14, 2004, Tsukuba, Japan / Japan Association of Chemical Sensors}, publisher = {Japan Association of Chemical Sensors}, address = {Fukuoka}, pages = {788 -- 789}, year = {2004}, language = {en} } @article{MottaghyVosteenSchellschmidt2008, author = {Mottaghy, Darius and Vosteen, Hans-Dieter and Schellschmidt, R{\"u}diger}, title = {Temperature dependence of the relationship of thermal diffusivity versus thermal conductivity for crystalline rocks}, series = {International Journal of Earth Sciences}, volume = {97}, journal = {International Journal of Earth Sciences}, number = {2}, issn = {1437-3262}, doi = {10.1007/s00531-007-0238-3}, pages = {435 -- 442}, year = {2008}, language = {en} } @article{MottaghySchwambornRath2013, author = {Mottaghy, Darius and Schwamborn, G. and Rath, V.}, title = {Past climate changes and permafrost depth at the Lake El'gygytgyn site: implications from data and thermal modeling}, series = {Climate of the Past}, volume = {9}, journal = {Climate of the Past}, number = {1}, publisher = {Copernicus}, address = {Katlenburg-Lindau}, issn = {1814-9332}, doi = {10.5194/cp-9-119-2013}, pages = {119 -- 133}, year = {2013}, language = {en} } @article{MottaghySchellschmidtPopovetal.2005, author = {Mottaghy, Darius and Schellschmidt, R. and Popov, Y. A. and Clauser, C. and Kukkonen, I. T. and Nover, G. and Milanovsky, S. and Romushkevich, R. A.}, title = {New heat flow data from the immediate vicinity of the Kola super-deep borehole: Vertical variation in heat flow density confirmed and attributed to advection}, series = {Tectonophysics}, volume = {401}, journal = {Tectonophysics}, number = {1-2}, issn = {1879-3266}, doi = {10.1016/j.tecto.2005.03.005}, pages = {119 -- 142}, year = {2005}, language = {en} } @article{MottaghyRath2006, author = {Mottaghy, Darius and Rath, Volker}, title = {Latent heat effects in subsurface heat transport modelling and their impact on palaeotemperature reconstructions}, series = {Geophysical Journal International}, volume = {164}, journal = {Geophysical Journal International}, number = {1}, issn = {1365-246X}, doi = {10.1111/j.1365-246X.2005.02843.x}, pages = {236 -- 245}, year = {2006}, language = {en} } @article{MottaghyPechnigVogt2011, author = {Mottaghy, Darius and Pechnig, Renate and Vogt, Christian}, title = {The geothermal project Den Haag: 3D numerical models for temperature prediction and reservoir simulation}, series = {Geothermics}, volume = {40}, journal = {Geothermics}, number = {3}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0375-6505}, doi = {10.1016/j.geothermics.2011.07.001}, pages = {199 -- 210}, year = {2011}, abstract = {The proposed Den Haag Zuidwest district heating system of the city of The Hague consists of a deep doublet in a Jurassic sandstone layer that is designed for a production temperature of 75 °C and a reinjection temperature of 40 °C at a flow rate of 150 m3 h-1. The prediction of reservoir temperature and production behavior is crucial for success of the proposed geothermal doublet. This work presents the results of a study of the important geothermal and geohydrological issues for the doublet design. In the first phase of the study, the influences of the three-dimensional (3D) structures of anticlines and synclines on the temperature field were examined. A comprehensive petrophysical investigation was performed to build a large scale 3D-model of the reservoir. Several bottomhole temperatures (BHTs), as well as petrophysical logs were used to calibrate the model using thermal conductivity measurements on 50 samples from boreholes in different lithological units in the study area. Profiles and cross sections extracted from the calculated temperature field were used to study the temperature in the surrounding areas of the planned doublet. In the second phase of the project, a detailed 3D numerical reservoir model was set up, with the aim of predicting the evolution of the producer and injector temperatures, and the extent of the cooled area around the injector. The temperature model from the first phase provided the boundary conditions for the reservoir model. Hydraulic parameters for the target horizons, such as porosity and permeability, were taken from data available from the nearby exploration wells. The simulation results are encouraging as no significant thermal breakthrough is predicted. For the originally planned location of the producer, the extracted water temperature is predicted to be around 79 °C, with an almost negligible cooling in the first 50 years of production. When the producer is located shallower parts of the reservoir, the yield water temperatures is lower, starting at ≈76 °C and decreasing to ≈74 °C after 50 years of operation. This comparatively larger decrease in temperature with time is caused by the structural feature of the reservoir, namely a higher dip causes the cooler water to easily move downward. In view of the poor reservoir data, the reservoir simulation model is constructed to allow iterative updates using data assimilation during planned drilling, testing, and production phases. Measurements during an 8 h pumping test carried out in late 2010 suggest that a flow rate of 150 m3 h-1 is achievable. Fluid temperatures of 76.5 °C were measured, which is very close to the predicted value.}, language = {en} } @incollection{MottaghyMajorowiczRath2009, author = {Mottaghy, Darius and Majorowicz, Jacek and Rath, Volker}, title = {Ground Surface Temperature Histories Reconstructed from Boreholes in Poland: Implications for Spatial Variability}, series = {The Polish Climate in the European Context: An Historical Overview}, booktitle = {The Polish Climate in the European Context: An Historical Overview}, publisher = {Springer Science+Business Media}, address = {Dordrecht}, isbn = {978-90-481-3167-9}, doi = {10.1007/978-90-481-3167-9_17}, pages = {375 -- 387}, year = {2009}, language = {en} } @article{MottaghyDijkshoorn2012, author = {Mottaghy, Darius and Dijkshoorn, Lydia}, title = {Implementing an effective finite difference formulation for borehole heat exchangers into a heat and mass transport code}, series = {Renewable Energy}, volume = {45}, journal = {Renewable Energy}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0960-1481}, doi = {10.1016/j.renene.2012.02.013}, pages = {59 -- 71}, year = {2012}, abstract = {We present an effective finite difference formulation for implementing and modeling multiple borehole heat exchangers (BHE) in the general 3-D coupled heat and flow transport code SHEMAT. The BHE with arbitrary length can be either coaxial or double U-shaped. It is particularly suitable for modeling deep BHEs which contain varying pipe diameters and materials. Usually, in numerical simulations, a fine discretization of the BHE assemblage is required, due to the large geometric aspect ratios involved. This yields large models and long simulation times. The approach avoids this problem by considering heat transport between fluid and the soil through pipes and grout via thermal resistances. Therefore, the simulation time can be significantly reduced. The coupling with SHEMAT is realized by introducing an effective heat generation. Due to this connection, it is possible to consider heterogeneous geological models, as well as the influence of groundwater flow. This is particularly interesting when studying the long term behavior of a single BHE or a BHE field. Heating and cooling loads can enter the model with an arbitrary interval, e.g. from hourly to monthly values. When dealing with large BHE fields, computing times can be further significantly reduced by focusing on the temperature field around the BHEs, without explicitly modeling inlet and outlet temperatures. This allows to determine the possible migration of cold and warm plumes due to groundwater flow, which is of particular importance in urban areas with a high BHE installation density. The model is validated against the existing BHE modeling codes EWS and EED. A comparison with monitoring data from a deep BHE in Switzerland shows a good agreement. Synthetic examples demonstrate the field of application of this model.}, language = {en} } @article{MossetDevroedeKriegueretal.2006, author = {Mosset, Jean-Baptiste and Devroede, Olivier and Krieguer, Magalie and Rey, M. and Vieira, J.-M. and Jung, J. H. and Kuntner, Claudia and Streun, Matthias and Ziemons, Karl and Auffray, Etiennette and Sempere-Roldan, P. and Lecoq, Paul and Bruyndonckx, Peter and Loude, Jean-Fran{\c{c}}ois and Tavernier, Stefaan and Morel, Christian}, title = {Development of an optimized LSO/LuYAP phoswich detector head for the Lausanne ClearPET demonstrator}, series = {IEEE Transactions on Nuclear Science}, volume = {53}, journal = {IEEE Transactions on Nuclear Science}, number = {1}, isbn = {0018-9499}, pages = {25 -- 29}, year = {2006}, abstract = {This paper describes the LSO/LuYAP phoswich detector head developed for the ClearPET small animal PET scanner demonstrator that is under construction in Lausanne within the Crystal Clear Collaboration. The detector head consists of a dual layer of 8×8 LSO and LuYAP crystal arrays coupled to a multi-anode photomultiplier tube (Hamamatsu R7600-M64). Equalistion of the LSO/LuYAP light collection is obtained through partial attenuation of the LSO scintillation light using a thin aluminum deposit of 20-35 nm on LSO and appropriate temperature regulation of the phoswich head between 30°C to 60°C. At 511keV, typical FWHM energy resolutions of the pixels of a phoswich head amounts to (28±2)\% for LSO and (25±2)\% for LuYAP. The LSO versus LuYAP crystal identification efficiency is better than 98\%. Six detector modules have been mounted on a rotating gantry. Axial and tangential spatial resolutions were measured up to 4 cm from the scanner axis and compared to Monte Carlo simulations using GATE. FWHM spatial resolution ranges from 1.3 mm on axis to 2.6 mm at 4 cm from the axis.}, language = {en} } @article{MoseleyHalamekKrameretal.2014, author = {Moseley, Fiona and Halamek, Jan and Kramer, Friederike and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible CNOT logic gate realized in a flow system}, series = {Analyst}, volume = {139}, journal = {Analyst}, number = {8}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1364-5528 (E-Journal) ; 0003-2654 (Print)}, doi = {10.1039/C4AN00133H}, pages = {1839 -- 1842}, year = {2014}, abstract = {An enzyme system organized in a flow device was used to mimic a reversible Controlled NOT (CNOT) gate with two input and two output signals. Reversible conversion of NAD⁺ and NADH cofactors was used to perform a XOR logic operation, while biocatalytic hydrolysis of p-nitrophenyl phosphate resulted in an Identity operation working in parallel. The first biomolecular realization of a CNOT gate is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} } @inproceedings{MoritzYoshinobuFingeretal.2003, author = {Moritz, Werner and Yoshinobu, Tatsuo and Finger, Friedhelm and Krause, Steffi and Sch{\"o}ning, Michael Josef}, title = {Amorphous silicon as semiconductor material for high resolution LAPS}, series = {Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimar{\~a}es, Portugal, September 21 - 24, 2003}, booktitle = {Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimar{\~a}es, Portugal, September 21 - 24, 2003}, pages = {48 -- 49}, year = {2003}, language = {en} } @article{MoritzYoshinobuFingeretal.2004, author = {Moritz, W. and Yoshinobu, T. and Finger, F. and Krause, S. and Xu, M. and Sch{\"o}ning, Michael Josef}, title = {Microscopy of impedance and surface ion concentrations}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {1000 -- 1001}, year = {2004}, language = {en} }