@article{Schnitzler2009,
  author    = {Schnitzler, Thomas},
  title     = {Kultivierung der Hybridomazelllinie CF-10H5 (DSMZ ACC477)},
  series = {Application notes / Sartorius stedim biotech},
  journal   = {Application notes / Sartorius stedim biotech},
  publisher = {Sartorius Stedim Biotec},
  address   = {Aubagne},
  year      = {2009},
  language  = {de}
}
@misc{WielandSiegertSpitzetal.2011,
  author    = {Wieland, Susanne and Siegert, Petra and Spitz, Astrid and Maurer, Karl-Heinz and O'Connell, Timothy and Pr{\"u}ser, Inken and Schiedel, Marc-Steffen and Eiting, Thomas and Sendor-M{\"u}ller, Dorota and Bastigkeit, Thorsten and Benda, Konstantin and M{\"u}ller, Sven},
  title     = {Lagerstabiles fl{\"u}ssiges Wasch- oder Reinigungsmittel enthaltend Proteasen [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO},
  address   = {M{\"u}nchen / Den Hague / Genf},
  pages     = {1 -- 25},
  year      = {2011},
  language  = {de}
}
@article{SchererKratzSchaedeletal.1988,
  author    = {Scherer, Ulrich W. and Kratz, J. V. and Sch{\"a}del, M. and Br{\"u}chle, W.},
  title     = {Lawrencium Chemistry: No Evidence for Oxidation States Lower than 3+ in Aqueous Solution / U.W. Scherer, J.V. Kratz, M. Sch{\"a}del, W. Br{\"u}chle, K.E. Gregorich, R.A. Henderson, D. Lee, M. Nurmia, D.C. Hoffman},
  series = {Inorganica Chimica Acta. 146 (1988)},
  journal   = {Inorganica Chimica Acta. 146 (1988)},
  isbn      = {0020-1693},
  pages     = {249 -- 254},
  year      = {1988},
  language  = {en}
}
@misc{BesslerEversMaureretal.2009,
  author    = {Bessler, Cornelius and Evers, Stefan and Maurer, Karl-Heinz and Merkel, Marion and Siegert, Petra and Weber, Angrit and Wieland, Susanne},
  title     = {Leistungsverbesserte Proteasen und Wasch- und Reinigungsmittel enthaltend diese Proteasen [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / WIPO},
  address   = {M{\"u}nchen / Genf},
  pages     = {1 -- 41},
  year      = {2009},
  language  = {de}
}
@misc{SiegertSchwanebergMartinezMoyaetal.2012,
  author    = {Siegert, Petra and Schwaneberg, Ulrich and Martinez Moya, Ronny and Merkel, Marion and Spitz, Astrid and Wieland, Susanne and Hellmuth, Hendrik and Maurer, Karl-Heinz},
  title     = {Leistungsverbesserte Proteasevariante [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO},
  address   = {M{\"u}nchen / Den Hague / Genf},
  pages     = {1 -- 29},
  year      = {2012},
  language  = {de}
}
@article{WeldenJablonskiWegeetal.2021,
  author    = {Welden, Rene and Jablonski, Melanie and Wege, Christina and Keusgen, Michael and Wagner, Patrick Hermann and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase},
  series = {Biosensors},
  volume    = {11},
  journal   = {Biosensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-6374},
  doi       = {10.3390/bios11060171},
  pages     = {Artikel 171},
  year      = {2021},
  abstract  = {The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte's pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS.},
  language  = {en}
}
@article{BreuerRaueKirschbaumetal.2015,
  author    = {Breuer, Lars and Raue, Markus and Kirschbaum, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten},
  title     = {Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431944},
  pages     = {1368 -- 1374},
  year      = {2015},
  abstract  = {Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.},
  language  = {en}
}
@inproceedings{BreuerRaueMangetal.2015,
  author    = {Breuer, Lars and Raue, Markus and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, Ronald and Wagner, Torsten},
  title     = {Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications},
  series = {12. Dresdner Sensor-Symposium 2015},
  booktitle = {12. Dresdner Sensor-Symposium 2015},
  doi       = {10.5162/12dss2015/P5.8},
  pages     = {206 -- 209},
  year      = {2015},
  language  = {en}
}
@article{BergsMonakhovaDiehletal.2021,
  author    = {Bergs, Michel and Monakhova, Yulia and Diehl, Bernd W. and Konow, Christopher and V{\"o}lkering, Georg and Pude, Ralf and Schulze, Margit},
  title     = {Lignins isolated via catalyst-free organosolv pulping from Miscanthus x giganteus, M. sinensis, M. robustus and M. nagara: a comparative study},
  series = {Molecules},
  volume    = {26},
  journal   = {Molecules},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1420-3049},
  doi       = {10.3390/molecules26040842},
  year      = {2021},
  abstract  = {As a low-input crop, Miscanthus offers numerous advantages that, in addition to agricultural applications, permits its exploitation for energy, fuel, and material production. Depending on the Miscanthus genotype, season, and harvest time as well as plant component (leaf versus stem), correlations between structure and properties of the corresponding isolated lignins differ. Here, a comparative study is presented between lignins isolated from M. x giganteus, M. sinensis, M. robustus and M. nagara using a catalyst-free organosolv pulping process. The lignins from different plant constituents are also compared regarding their similarities and differences regarding monolignol ratio and important linkages. Results showed that the plant genotype has the weakest influence on monolignol content and interunit linkages. In contrast, structural differences are more significant among lignins of different harvest time and/or season. Analyses were performed using fast and simple methods such as nuclear magnetic resonance (NMR) spectroscopy. Data was assigned to four different linkages (A: β-O-4 linkage, B: phenylcoumaran, C: resinol, D: β-unsaturated ester). In conclusion, A content is particularly high in leaf-derived lignins at just under 70\% and significantly lower in stem and mixture lignins at around 60\% and almost 65\%. The second most common linkage pattern is D in all isolated lignins, the proportion of which is also strongly dependent on the crop portion. Both stem and mixture lignins, have a relatively high share of approximately 20\% or more (maximum is M. sinensis Sin2 with over 30\%). In the leaf-derived lignins, the proportions are significantly lower on average. Stem samples should be chosen if the highest possible lignin content is desired, specifically from the M. x giganteus genotype, which revealed lignin contents up to 27\%. Due to the better frost resistance and higher stem stability, M. nagara offers some advantages compared to M. x giganteus. Miscanthus crops are shown to be very attractive lignocellulose feedstock (LCF) for second generation biorefineries and lignin generation in Europe.},
  language  = {en}
}
@misc{PothMonzonTippkoetteretal.2010,
  author    = {Poth, S. and Monzon, M. and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Lignocellulose-Bioraffinerie: Simultane Verzuckerung und Fermentation},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  doi       = {10.1002/cite.201050360},
  pages     = {1568},
  year      = {2010},
  abstract  = {Die am h{\"a}ufigsten genutzten Rohstoffe f{\"u}r die Produktion von Treibstoffen und Chemikalien sind fossilen Ursprungs. Da diese limitiert sind, werden im Hinblick auf die Nachhaltigkeit alternative, erneuerbare Rohstoffquellen intensiv untersucht. Vielversprechend in diesem Kontext sind die in Lignocellulose enthaltenen Zucker, die beispielsweise zur Produktion von Ethanol genutzt werden k{\"o}nnen. In der Regel sind f{\"u}r eine Lig-nocellulose-Bioraffinerie mehrere Prozessschritte notwendig: Vorbehandlung, Verzuckerung und Fermentation. Um diesen Prozess einfacher zu gestalten, ist es m{\"o}glich, die Verzuckerung und die Fermentation in einem Schritt durchzuf{\"u}hren (SSF). Als Substrat wird hier Cellulose-Faserstoff verwendet, der durch das Organosolv-Verfahren aufgeschlossen wurde. Die Hydrolyse erfolgt mit kommerziell erh{\"a}ltlichen Enzymen und f{\"u}r die Fermentation zu Ethanol werden zwei Hefen verwendet. Beim SSF-Verfahren konnte, im Vergleich zur entkoppelten Verfahrensweise, trotz bestehender Unterschiede in den Temperatur-Optima von Enzymen und Hefen eine Steigerung in der Ethanol-Ausbeute von 0,15 auf 0,2 gg⁻¹ beobachtet werden. Um wirtschaftliche Ausbeuten und Konzentrationen des Produkts erzielen zu k{\"o}nnen, ist es notwendig den Prozess weiter zu optimieren. Im Einzelfall muss {\"u}berpr{\"u}ft werden, ob diese Verfahrensweise auch f{\"u}r die Produktion anderer interessanter Stoffe (wie Itacons{\"a}ure, Bernsteins{\"a}ure) geeignet ist.},
  language  = {de}
}
@incollection{DuweTippkoetterUlber2018,
  author    = {Duwe, A. and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Lignocellulose-Biorefinery: Ethanol-Focused},
  series = {Biorefineries},
  booktitle = {Biorefineries},
  publisher = {Springer},
  address   = {Cham},
  doi       = {10.1007/10_2016_72},
  pages     = {177 -- 215},
  year      = {2018},
  abstract  = {The development prospects of the world markets for petroleum and other liquid fuels are diverse and partly contradictory. However, comprehensive changes for the energy supply of the future are essential. Notwithstanding the fact that there are still very large deposits of energy resources from a geological point of view, the finite nature of conventional oil reserves is indisputable. To reduce our dependence on oil, the EU, the USA, and other major economic zones rely on energy diversification. For this purpose, alternative materials and technologies are being sought, and is most obvious in the transport sector. The objective is to progressively replace fossil fuels with renewable and more sustainable fuels. In this respect, biofuels have a pre-eminent position in terms of their capability of blending with fossil fuels and being usable in existing cars without substantial modification. Ethanol can be considered as the primary renewable liquid fuel. In this chapter enzymes, micro-organisms, and processes for ethanol production based on renewable resources are described.},
  language  = {en}
}
@inproceedings{PothMonzonTippkoetteretal.2010,
  author    = {Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Lignocellulosic biorefinery : process integration of hydrolysis and fermentation},
  series = {Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany},
  booktitle = {Proceedings / 11th European Workshop on Lignocellulosics and Pulp : August 16 - 19, 2010, Hamburg, Germany},
  publisher = {vTi},
  address   = {Hamburg},
  pages     = {65 -- 68},
  year      = {2010},
  language  = {en}
}
@article{PothMonzonTippkoetteretal.2011,
  author    = {Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Lignocellulosic biorefinery: Process integration of hydrolysis and fermentation (SSF process)},
  series = {Holzforschung},
  volume    = {65},
  journal   = {Holzforschung},
  number    = {5},
  publisher = {De Gruyter},
  address   = {Berlin},
  pages     = {633 -- 637},
  year      = {2011},
  abstract  = {The aim of the present work is the process integration and the optimization of the enzymatic hydrolysis of wood and the following fermentation of the products to ethanol. The substrate is a fiber fraction obtained by organosolv pre-treatment of beech wood. For the ethanol production, a co-fermentation by two different yeasts (Saccharomyces cerevisiae and Pachysolen tannophilus) was carried out to convert glucose as well as xylose. Two approaches has been followed: 1. A two step process, in which the hydrolysis of the fiber fraction and the fermentation to product are separated from each other. 2. A process, in which the hydrolysis and the fermentation are carried out in one single process step as simultaneous saccharification and fermentation (SSF). Following the first approach, a yield of about 0.15 g ethanol per gram substrate can be reached. Based on the SSF, one process step can be saved, and additionally, the gained yield can be raised up to 0.3 g ethanol per gram substrate.},
  language  = {en}
}
@inproceedings{EngelThieringerTippkoetter2016,
  author    = {Engel, Mareike and Thieringer, Julia and Tippk{\"o}tter, Nils},
  title     = {Linking bioprocess engineering and electrochemistry for sustainable biofuel production},
  series = {Young Researchers Symposium, YRS 2016. Proceedings},
  booktitle = {Young Researchers Symposium, YRS 2016. Proceedings},
  publisher = {Fraunhofer Verlag},
  address   = {Karlsruhe},
  pages     = {49 -- 53},
  year      = {2016},
  abstract  = {Electromicrobial engineering is an emerging, highly interdisciplinary research area linking bioprocesses with electrochemistry. In this work, microbial electrosynthesis (MES) of biobutanol is carried out during acetone-butanol-ethanol (ABE) fermentations with Clostridium acetobutylicum. A constant electric potential of -600mV (vs. Ag/AgCl) with simultaneous addition of the soluble redox mediator neutral red is used in order to study the electron transfer between the working electrode and the bacterial cells. The results show an earlier initiation of solvent production for all fermentations with applied potential compared to the conventional ABE fermentation. The f inal butanol concentration can be more than doubled by the application of a negative potential combined with addition of neutral red. Moreover a higher biofilm formation on the working electrode compared to control cultivations has been observed. In contrast to previous studies, our results also indicate that direct electron transfer (DET) might be possible with C. acetobutylicum. The presented results make microbial butanol production economically attractive and therefore support the development of sustainable production processes in the chemical industry aspired by the "Centre for resource-efficient chemistry and raw material change" as well as the the project "NanoKat" working on nanostructured catalysts in Kaiserslautern.},
  language  = {en}
}
@misc{BanowskiWadleSiegertetal.2004,
  author    = {Banowski, Bernhard and Wadle, Armin and Siegert, Petra and S{\"a}ttler, Andrea},
  title     = {Lipase-Inhibitoren in Deodorantien und Antitranspirantien [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt},
  address   = {M{\"u}nchen / Den Hague},
  pages     = {1 -- 22},
  year      = {2004},
  language  = {de}
}
@article{PrielmeierHoerstermannGyngelletal.1992,
  author    = {Prielmeier, Franz and H{\"o}rstermann, D. and Gyngell, M. L. and Merboldt, K.-D.},
  title     = {Localized Proton MRS of Acute and Chronic Gyperglycemia in Rat Brain in vivo / D. H{\"o}rstermann, F. Prielmeier , M. L. Gyngell, K.-D. Merboldt, W. H{\"a}nicke, J. Frahm},
  series = {Book of Abstracts, SMRM, 11th Annual Meeting Berlin},
  journal   = {Book of Abstracts, SMRM, 11th Annual Meeting Berlin},
  pages     = {2740},
  year      = {1992},
  language  = {en}
}
@incollection{TippkoetterMoehringRothetal.2019,
  author    = {Tippk{\"o}tter, Nils and M{\"o}hring, Sophie and Roth, Jasmine and Wulfhorst, Helene},
  title     = {Logistics of lignocellulosic feedstocks: preprocessing as a preferable option},
  series = {Biorefineries},
  booktitle = {Biorefineries},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-97117-9},
  doi       = {10.1007/10_2017_58},
  pages     = {43 -- 68},
  year      = {2019},
  abstract  = {In comparison to crude oil, biorefinery raw materials are challenging in concerns of transport and storage. The plant raw materials are more voluminous, so that shredding and compacting usually are necessary before transport. These mechanical processes can have a negative influence on the subsequent biotechnological processing and shelf life of the raw materials. Various approaches and their effects on renewable raw materials are shown. In addition, aspects of decentralized pretreatment steps are discussed. Another important aspect of pretreatment is the varying composition of the raw materials depending on the growth conditions. This problem can be solved with advanced on-site spectrometric analysis of the material.},
  language  = {en}
}
@article{MeinersBaumann1997,
  author    = {Meiners, Klaus and Baumann, Marcus},
  title     = {Lokale Beitr{\"a}ge zum globalen Klimaschutz},
  series = {Wechselwirkung : Wissenschaft \& vernetztes Denken},
  volume    = {19},
  journal   = {Wechselwirkung : Wissenschaft \& vernetztes Denken},
  number    = {84},
  issn      = {0172-1623},
  pages     = {6 -- 12},
  year      = {1997},
  language  = {de}
}
@techreport{Tippkoetter2018,
  author    = {Tippk{\"o}tter, Nils},
  title     = {Lokale Vorbehandlung nachwachsender Rohstoffe f{\"u}r Bioraffinerien (BioSats) : Schlussbericht zum Vorhaben : Laufzeit: 01.03.2012 bis 30.04.2017},
  organization    = {Technische Universit{\"a}t Kaiserslautern},
  doi       = {10.2314/GBV:1024204243},
  pages     = {191 Seiten},
  year      = {2018},
  language  = {de}
}
@article{AdelsMonakhova2024,
  author    = {Adels, Klaudia and Monakhova, Yulia},
  title     = {Low-field NMR spectroscopic study of e-cigarettes: Is determination of only nicotine and organic carrier solvents possible?},
  series = {Microchemical Journal},
  volume    = {203},
  journal   = {Microchemical Journal},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1095-9149},
  doi       = {10.1016/j.microc.2024.110859},
  pages     = {9 Seiten},
  year      = {2024},
  abstract  = {Electronic cigarettes (e-cigarettes) have become popular worldwide with the market growing exponentially in some countries. The absence of product standards and safety regulations requires urgent development of analytical methodologies for the holistic control of the growing diversity of such products. An approach based on low-field nuclear magnetic resonance (LF-NMR) at 80 MHz is presented for the simultaneous determination of key parameters: carrier solvents (vegetable glycerine (VG), propylene glycol (PG) and water), total nicotine as well as free-base nicotine fraction. Moreover, qualitative and quantitative determination of fourteen weak organic acids deliberately added to enhance sensory characteristics of e-cigarettes was possible. In most cases these parameters can be rapidly and conveniently determined without using any sample manipulation such as dilution, extraction or derivatization steps. The method was applied for 37 authentic e-cigarettes samples. In particular, eight different organic acids with the content up to 56 mg/mL were detected. Due to its simplicity, the method can be used in routine regulatory control as well as to study release behaviour of nicotine and other e-cigarettes constituents in different products.},
  language  = {en}
}
@misc{TippkoetterPasteurUlber2012,
  author    = {Tippk{\"o}tter, Nils and Pasteur, A. and Ulber, Roland},
  title     = {Magnetisch abtrennbare Gold-Nanopartikel zur katalytischen Zuckeroxidation},
  series = {Chemie Ingenieur Technik},
  volume    = {84},
  journal   = {Chemie Ingenieur Technik},
  number    = {8},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201250393},
  pages     = {1328},
  year      = {2012},
  abstract  = {Glucose ist ein prim{\"a}res Zwischenprodukt der Verarbeitung nachwachsender Rohstoffe, wie z. B. Cellulose. Die wertsteigernde Weiterverarbeitung des Monosaccharids erfolgt h{\"a}ufig in Form vonFermentationsprozessen, jedoch kann der Rohstoff auch f{\"u}r zahlreiche chemische Verarbeitungsstufen genutzt werden. Ein großtechnisch relevanter Prozess ist die Herstellung von Glucons{\"a}ure (GS), die u. a. als Nahrungsmittelzusatz (E 574) eingesetzt wird. Die Darstellung der S{\"a}ure erfolgt durch Oxidation von Glucose mit magnetisierbarem Gold-Nano-Katalysator. Die R{\"u}ckgewinnung des Katalysators aus der Reaktionsl{\"o}sung wurde unter Einwirkung eines Magnetfeldgradienten verwirklicht. Die Synthese der magnetischen Goldkatalysatoren (sowohl Tr{\"a}gerpartikel als auch Gold-Nanopartikel) wurde durch nass-chemische F{\"a}llungsreaktionen durchgef{\"u}hrt. Die Charakteristiken der neuen Materialen konnte durch Messungen des PCD-Potenzials, Laserbeugung und REM/EDX untersucht werden. So wurden u. a. Partikeldurchmesser von 25 lm und ein Goldgehaltvon 1,03 \% ermittelt. Weiterhin wurden f{\"u}r die Goldkatalysatoren optimale Reaktionsbedingungen f{\"u}r die Glucoseoxidation im geregelten R{\"u}hrkesselreaktor etabliert. Hierdurch konnten eine Produktselektivit{\"a}t von 100 \% und eine Wiederverwendbarkeit der Partikel {\"u}ber mindestens zehn Zyklen erreicht werden.},
  language  = {de}
}
@article{Mang2005,
  author    = {Mang, Thomas},
  title     = {Magnetische Mikro- und Nanopartikel f{\"u}r Medizin und Biotechnik},
  series = {W{\"a}ssrige Kunststoffdispersionen und ihre Anwendung : Fachbereich Angewandte Naturwissenschaften und Technik / Fachhochschule Aachen. [Schriftleitung: Thomas Mang ...]},
  journal   = {W{\"a}ssrige Kunststoffdispersionen und ihre Anwendung : Fachbereich Angewandte Naturwissenschaften und Technik / Fachhochschule Aachen. [Schriftleitung: Thomas Mang ...]},
  publisher = {Fachhochschule Aachen},
  address   = {Aachen},
  pages     = {137 -- 150},
  year      = {2005},
  language  = {de}
}
@misc{HeringPasteurWollnyetal.2014,
  author    = {Hering, T. and Pasteur, A. and Wollny, S. and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Magnetische Separation von Gold-Nanopartikeln zur Glucons{\"a}ure-Produktion durch Hochgradient-Magnetseparation im Labormaßstab},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450265},
  pages     = {1501},
  year      = {2014},
  abstract  = {Bei der Verarbeitung nachwachsender Rohstoffe entsteht aus Cellulose oder St{\"a}rke u. a. das wichtige Produkt Glucose. Diese niedermolekulare Kohlenhydratquelle wird {\"u}blicherweise als Substrat f{\"u}r biotechnologische und chemische Synthesen verwendet. Ein wirtschaftlich interessantes Oxidationsprodukt der Glucose ist Glucons{\"a}ure, die beispielsweise als Lebensmittelzusatzstoff (E 574), in der Medizin und Metallindustrie Verwendung findet. Die Umsetzung des Monosaccharids zu Glucons{\"a}ure erfolgt entweder durch mikrobielle Fermentation oder der Oxidation an heterogenen Katalysatoren. Die Zielsetzung der Studie ist die Untersuchung der Glucoseoxidation an magnetisierbaren Gold-Nanopartikeln unter nachfolgender Bypass-Separation des Katalysators mittels einer neuen Mini-HGMS-Einheit (Hochgradient-Magnetseparation). Dieser Filtertyp erm{\"o}glicht die selektive Trennung magnetischer Partikel aus Suspensionen mit hohem Feststoffgehalt oder Viskosit{\"a}t. Erste Ergebnisse zeigen eine Beladungskapazit{\"a}t des selbstkonstruierten Mini-HGMS von 550 mg goldbeschichteter magnetisierbarer Nanopartikel. Die Oxidation erfolgt bei einem pH-Wertvon 9, bei 40 °C und mit 100 mM Glucose in einem begasten R{\"u}hrkesselreaktor. Das System soll zuk{\"u}nftig zum Katalysatorrecycling von hochviskosen und Feststoffbelasteten Produktstr{\"o}men aus Bioraffinerien eingesetzt werden.},
  language  = {de}
}
@article{TippkoetterWollnyKampeisetal.2011,
  author    = {Tippk{\"o}tter, Nils and Wollny, S. and Kampeis, P. and Oster, J. and Schneider, H. and Ulber, Roland},
  title     = {Magnetseparation von Proteinen : Separation von Zielmolek{\"u}len durch hochselektive Aptamere},
  series = {GIT Labor-Fachzeitschrift},
  volume    = {55},
  journal   = {GIT Labor-Fachzeitschrift},
  number    = {10},
  publisher = {Wiley},
  address   = {Weinheim},
  pages     = {666},
  year      = {2011},
  abstract  = {Durch die Kombination von Oligonukleotid-Liganden (Aptameren) hoher Bindungsaffinit{\"a}ten mit hochselektiv abtrennbaren magnetisierbaren Mikropartikeln wird eine einstufige Separation von Zielmolek{\"u}len aus mikrobiologischen Produktionsans{\"a}tzen m{\"o}glich. Die Aptamere werden hierf{\"u}r reversibel auf den Partikeloberfl{\"a}chen gebunden und f{\"u}r die spezifische Isolierung von Bioprodukten eingesetzt. Die Abtrennung der beladenen Partikel erfolgt durch einen neuen Rotor-Stator-Separator mit Hochgradient-Magnetfeld.},
  language  = {de}
}
@article{SchmidtTurgutLeetal.2020,
  author    = {Schmidt, Aaron C. and Turgut, Hatice and Le, Dao and Beloqui, Ana and Delaittre, Guillaume},
  title     = {Making the best of it: nitroxide-mediated polymerization of methacrylates via the copolymerization approach with functional styrenics},
  series = {Polymer Chemistry},
  volume    = {11},
  journal   = {Polymer Chemistry},
  number    = {2},
  publisher = {Royal Society of Chemistry (RSC)},
  address   = {Cambridge},
  doi       = {10.1039/C9PY01458F},
  pages     = {593 -- 604},
  year      = {2020},
  abstract  = {The SG1-mediated solution polymerization of methyl methacrylate (MMA) and oligo(ethylene glycol) methacrylate (OEGMA, Mₙ = 300 g mol⁻¹) in the presence of a small amount of functional/reactive styrenic comonomer is investigated. Moieties such as pentafluorophenyl ester, triphenylphosphine, azide, pentafluorophenyl, halide, and pyridine are considered. A comonomer fraction as low as 5 mol\% typically results in a controlled/living behavior, at least up to 50\% conversion. Chain extensions with styrene for both systems were successfully performed. Variation of physical properties such as refractive index (for MMA) and phase transition temperature (for OEGMA) were evaluated by comparing to 100\% pure homopolymers. The introduction of an activated ester styrene derivative in the polymerization of OEGMA allows for the synthesis of reactive and hydrophilic polymer brushes with defined thickness. Finally, using the example of pentafluorostyrene as controlling comonomer, it is demonstrated that functional PMMA-b-PS are able to maintain a phase separation ability, as evidenced by the formation of nanostructured thin films.},
  language  = {en}
}
@article{BaumannJahnke1986,
  author    = {Baumann, Marcus and Jahnke, J.},
  title     = {Marine Planktonalgen der Arktis I. Die Haptophycee Phaeocystis pouchetii / Baumann, M. ; Jahnke, J.},
  series = {Mikrokosmos. 75 (1986), H. 9},
  journal   = {Mikrokosmos. 75 (1986), H. 9},
  isbn      = {0026-3680},
  pages     = {262 -- 265},
  year      = {1986},
  language  = {de}
}
@article{BaumannKraemer1986,
  author    = {Baumann, Marcus and Kr{\"a}mer, M.},
  title     = {Marine Planktonalgen der Arktis II. Diatomeen / Baumann, M. ; Kr{\"a}mer, M.},
  series = {Mikrokosmos. 75 (1986), H. 10},
  journal   = {Mikrokosmos. 75 (1986), H. 10},
  isbn      = {0026-3680},
  pages     = {306 -- 310},
  year      = {1986},
  language  = {de}
}
@article{FeuerriegelKuenschStahlbergetal.1994,
  author    = {Feuerriegel, Uwe and K{\"u}nsch, M. and Stahlberg, R. and Steiger, F.},
  title     = {Massen- und Energiebilanz des Thermoselect-Verfahrens},
  series = {Thermoselect-Verfahren zur Ent- und Vergasung von Abf{\"a}llen / Franz J. Schweitzer [Hrsg.]},
  journal   = {Thermoselect-Verfahren zur Ent- und Vergasung von Abf{\"a}llen / Franz J. Schweitzer [Hrsg.]},
  publisher = {EF-Verl. f{\"u}r Energie- u. Umwelttechnik},
  address   = {Berlin},
  isbn      = {3-924511-47-0},
  pages     = {207 S. : graph. Darst.},
  year      = {1994},
  language  = {de}
}
@article{FeuerriegelStahlbergWeisenburgeretal.1995,
  author    = {Feuerriegel, Uwe and Stahlberg, R. and Weisenburger, P. and Steiger, F.},
  title     = {Massen- und Energiebilanzen unter Einbeziehung der Untersuchungen an der Thermoselect-Anlage Fondotoce (Italien). Stahlberg, R.; Feuerriegel, U.; Weisenburger, P.; Steiger, F.},
  series = {Thermoselect : der neue Weg, Restm{\"u}ll umweltgerecht zu behandeln ; [Tagungsband zur Fachtagung Thermoselect am 19. Januar 1995 in Rastatt/Baden] / G{\"u}nther H{\"a}ßler. 2. durchges. und erw. Aufl.},
  journal   = {Thermoselect : der neue Weg, Restm{\"u}ll umweltgerecht zu behandeln ; [Tagungsband zur Fachtagung Thermoselect am 19. Januar 1995 in Rastatt/Baden] / G{\"u}nther H{\"a}ßler. 2. durchges. und erw. Aufl.},
  publisher = {Goerner},
  address   = {Karlsruhe},
  isbn      = {3-9803665-4-5},
  pages     = {55 -- 84},
  year      = {1995},
  language  = {de}
}
@article{LiuSchaapBallemansetal.2017,
  author    = {Liu, Z. and Schaap, K. S. and Ballemans, L. and de Blois, E. and Rohde, M. and Paulßen, Elisabeth},
  title     = {Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system},
  series = {Dalton Transactions},
  volume    = {46},
  journal   = {Dalton Transactions},
  number    = {42},
  issn      = {1477-9234},
  doi       = {10.1039/C7DT01830D},
  pages     = {14669 -- 14676},
  year      = {2017},
  language  = {en}
}
@article{SeifarthGrosseGrossmannetal.2017,
  author    = {Seifarth, Volker and Grosse, Joachim O. and Grossmann, Matthias and Janke, Heinz Peter and Arndt, Patrick and Koch, Sabine and Epple, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation},
  series = {Journal of Biomaterials Applications},
  volume    = {32},
  journal   = {Journal of Biomaterials Applications},
  number    = {3},
  publisher = {Sage},
  address   = {London},
  issn      = {1530-8022},
  doi       = {10.1177/0885328217723178},
  pages     = {321 -- 330},
  year      = {2017},
  language  = {en}
}
@misc{RothkranzKrafftTippkoetter2022,
  author    = {Rothkranz, Berit and Krafft, Simone and Tippk{\"o}tter, Nils},
  title     = {Media optimization for sustainable fuel production: How to produce biohydrogen from renewable resources with Thermotoga neapolitana},
  series = {Chemie Ingenieur Technik},
  volume    = {94},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.202255305},
  pages     = {1298 -- 1299},
  year      = {2022},
  abstract  = {Hydrogen is playing an increasingly important role in research and politics as an energy carrier of the future. Since hydrogen has commonly been produced from methane by steam reforming, the need for climate-friendly, alternative production routes is emerging. In addition to electrolysis, fermentative routes for the production of so-called biohydrogen are "green" alternatives. The application of microorganisms offers the advantage of sustainable production from renewable resources using easily manageable technologies. In this project, the hyperthermophilic, anaerobic microorganism Thermotoga neapolitana is used for the productio nof biohydrogen from renewable resources. The enzymatically hydrolyzed resources were used in fermentation leading to yield coefficients of 1.8 mole H₂ per mole glucose when using hydrolyzed straw and ryegrass supplemented with medium, respectively. These results are similar to the hydrogen yields when using Thermotoga basal medium with glucose (TBGY) as control group. In order to minimize the supplementation of the hydrolysate and thus increase the economic efficiency of the process, the essential media components were identified. The experiments revealed NaCl, KCl, and glucose as essential components for cell growth as well as biohydrogen production. When excluding NaCl, a decrease of 96\% in hydrogen production occured.},
  language  = {en}
}
@article{InagakiSleddensLinkelsWassenaaretal.2011,
  author    = {Inagaki, Akiko and Sleddens-Linkels, Esther and Wassenaar, Evelyne and Ooms, Marja and Cappellen, Wiggert A. van and Hoeijmakers, Jan H. J. and Seibler, Jost and Vogt, Thomas F. and Shin, Myung K. and Grootegoed, J. Anton and Baarends, Willy M.},
  title     = {Meiotic functions of RAD18},
  series = {Journal of Cell Science},
  volume    = {124},
  journal   = {Journal of Cell Science},
  number    = {16},
  publisher = {Company of Biologists Limited},
  address   = {Cambridge},
  issn      = {1477-9137},
  doi       = {10.1242/jcs.081968},
  pages     = {2837 -- 2850},
  year      = {2011},
  language  = {en}
}
@article{TrappLammersEngudaretal.2023,
  author    = {Trapp, Svenja and Lammers, Tom and Engudar, Gokce and Hoehr, Cornelia and Denkova, Antonia G. and Paulßen, Elisabeth and de Kruijff, Robin M.},
  title     = {Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop},
  series = {EJNMMI Radiopharmacy and Chemistry},
  volume    = {2023},
  journal   = {EJNMMI Radiopharmacy and Chemistry},
  number    = {8, Article number: 9},
  publisher = {Springer Nature},
  issn      = {2365-421X},
  doi       = {10.1186/s41181-023-00195-2},
  pages     = {1 -- 14},
  year      = {2023},
  language  = {en}
}
@article{HarishWriggersJungketal.2016,
  author    = {Harish, Ajay B. and Wriggers, Peter and Jungk, Juliane and Hojdis, Nils and Recker, Carla},
  title     = {Mesoscale Constitutive Modeling of Non-Crystallizing Filled Elastomers},
  series = {Computational Mechanics},
  volume    = {57},
  journal   = {Computational Mechanics},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1432-0924},
  doi       = {10.1007/s00466-015-1251-1},
  pages     = {653 -- 677},
  year      = {2016},
  abstract  = {Elastomers are exceptional materials owing to their ability to undergo large deformations before failure. However, due to their very low stiffness, they are not always suitable for industrial applications. Addition of filler particles provides reinforcing effects and thus enhances the material properties that render them more versatile for applications like tyres etc. However, deformation behavior of filled polymers is accompanied by several nonlinear effects like Mullins and Payne effect. To this day, the physical and chemical changes resulting in such nonlinear effect remain an active area of research. In this work, we develop a heterogeneous (or multiphase) constitutive model at the mesoscale explicitly considering filler particle aggregates, elastomeric matrix and their mechanical interaction through an approximate interface layer. The developed constitutive model is used to demonstrate cluster breakage, also, as one of the possible sources for Mullins effect observed in non-crystallizing filled elastomers.},
  language  = {en}
}
@article{ElbersRichter1994,
  author    = {Elbers, Gereon and Richter, J.},
  title     = {Messung kraftfahrzeugbedingter Rußimmissionen},
  series = {Staub, Reinhaltung der Luft : air quality control. 54 (1994)},
  journal   = {Staub, Reinhaltung der Luft : air quality control. 54 (1994)},
  isbn      = {0039-0771},
  pages     = {19},
  year      = {1994},
  language  = {de}
}
@article{Elbers1993,
  author    = {Elbers, Gereon},
  title     = {Messung von Ruß in der Außenluft - Praktische Erfahrungen und Meßergebnisse aus NRW},
  series = {Aktuelle Aufgaben der Messtechnik in der Luftreinhaltung : Kolloquium Heidelberg, 2. bis 4. Juni 1993 / Kommission Reinhaltung der Luft im VDI und DIN},
  journal   = {Aktuelle Aufgaben der Messtechnik in der Luftreinhaltung : Kolloquium Heidelberg, 2. bis 4. Juni 1993 / Kommission Reinhaltung der Luft im VDI und DIN},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {3-18-091059-3},
  pages     = {337},
  year      = {1993},
  language  = {de}
}
@article{BongaertsKraemerMuelleretal.2001,
  author    = {Bongaerts, Johannes and Kr{\"a}mer, Marco and M{\"u}ller, Ulrike and Raeven, Leon and Wubbolts, Marcel},
  title     = {Metabolic engineering for microbial production of aromatic amino acids and derived compounds},
  series = {Metabolic engineering},
  volume    = {Vol. 3},
  journal   = {Metabolic engineering},
  number    = {Iss. 4},
  issn      = {1096-7184 (E-Journal); 1096-7176 (Print)},
  pages     = {289 -- 300},
  year      = {2001},
  language  = {en}
}
@article{KraemerBongaertsBovenbergetal.2003,
  author    = {Kr{\"a}mer, Marco and Bongaerts, Johannes and Bovenberg, Roel and Kremer, Susanne and M{\"u}ller, Ulrike and Orf, Sonja and Wubbolts, Marcel and Raeven, Leon},
  title     = {Metabolic engineering for microbial production of shikimic acid},
  series = {Metabolic engineering},
  volume    = {Vol. 5},
  journal   = {Metabolic engineering},
  number    = {Iss. 4},
  issn      = {1096-7184 (E-Journal); 1096-7176 (Print)},
  pages     = {277 -- 283},
  year      = {2003},
  language  = {en}
}
@article{MuellerBongaertsBovenbergetal.2001,
  author    = {M{\"u}ller, Ulrike and Bongaerts, Johannes and Bovenberg, Roel and Jossek, Ralf and Kr{\"a}mer, Marco and Linnemann, J. and M{\"u}schen, S. and Ritterbecks, S. and Sprenger, G. and Wubbolts, Marcel},
  title     = {Metabolic engineering to produce fine chemicals in Escherichia coli},
  series = {Mededelingen van de Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent},
  volume    = {66 (3a)},
  journal   = {Mededelingen van de Faculteit Landbouwwetenschappen, Rijksuniversiteit Gent},
  issn      = {0035-533x},
  pages     = {215 -- 217},
  year      = {2001},
  language  = {en}
}
@article{BongaertsBovenbergKraemeretal.2002,
  author    = {Bongaerts, Johannes and Bovenberg, Roel and Kr{\"a}mer, Marco and M{\"u}ller, Ulrike and Raeven, Leon and Wubbolts, Marcel},
  title     = {Metabolic engineering to produce fine chemicals in Escherichia coli},
  series = {Chemie - Ingenieur - Technik (CIT)},
  volume    = {Vol. 74},
  journal   = {Chemie - Ingenieur - Technik (CIT)},
  number    = {Iss. 5},
  issn      = {1522-2640 (E-Journal); 0009-286X (Print)},
  pages     = {694},
  year      = {2002},
  language  = {en}
}
@article{HuckSchiffelsHerreraetal.2013,
  author    = {Huck, Christina and Schiffels, Johannes and Herrera, Cony N. and Schelden, Maximilian and Selmer, Thorsten and Poghossian, Arshak and Baumann, Marcus and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor},
  series = {Physica Status Solidi (A)},
  volume    = {210},
  journal   = {Physica Status Solidi (A)},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0031-8965},
  doi       = {10.1002/pssa.201200900},
  pages     = {926 -- 931},
  year      = {2013},
  abstract  = {Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the "welfare" of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis-Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.},
  language  = {en}
}
@article{WilmingBegemannKuhneetal.2013,
  author    = {Wilming, Anja and Begemann, Jens and Kuhne, Stefan and Regestein, Lars and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and B{\"u}chs, Jochen},
  title     = {Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations},
  series = {Biochemical engineering journal},
  volume    = {Vol. 73},
  journal   = {Biochemical engineering journal},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-295X (E-Journal); 1369-703X (Print)},
  pages     = {29 -- 37},
  year      = {2013},
  language  = {en}
}
@misc{O'ConnellSiegertMaureretal.2010,
  author    = {O'Connell, Timothy and Siegert, Petra and Maurer, Karl-Heinz and Schiedel, Marc-Steffen and Vockenroth, Inga Kerstin},
  title     = {Method for improving the cleaning action of a detergent or cleaning agent [Internationale Patentanmeldung]},
  publisher = {WIPO},
  address   = {Genf},
  pages     = {1 -- 15},
  year      = {2010},
  language  = {en}
}
@misc{StadtmuellerTippkoetterUlber2015,
  author    = {Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Method for production of single-stranded macronucleotides},
  year      = {2015},
  abstract  = {The invention relates to a method for production of single-stranded macronucleotides by amplifying and ligating an extended monomeric single-stranded target nucleic acid sequence (targetss) into a repetitive cluster of double-stranded target nucleic acid sequences (targetds), and subsequently cloning the construct into a vector (aptagene vector). The aptagene vector is transformed into host cells for replication of the aptagene and isolated in order to optain single-stranded target sequences (targetss). The invention also relates to single-stranded nucleic acids, produced by a method of the invention.},
  language  = {en}
}
@article{SelmerPinkenburg2008,
  author    = {Selmer, Thorsten and Pinkenburg, Olaf},
  title     = {Method of cloning at least one nucleic acid molecule of interest using type IIS restriction endonucleases, and corresponding cloning vectors, kits and system using type IIS restriction endonucleases / Selmer, Thorsten ; Pinkenburg, Olaf},
  year      = {2008},
  language  = {en}
}
@inproceedings{EngelThieringerTippkoetter2016,
  author    = {Engel, M. and Thieringer, J. and Tippk{\"o}tter, Nils},
  title     = {Microbial electrosynthesis for sustainable biobutanol production},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {77 -- 78},
  year      = {2016},
  language  = {en}
}
@article{BaeckerRaueSchusseretal.2012,
  author    = {B{\"a}cker, Matthias and Raue, Markus and Schusser, Sebastian and Jeitner, C. and Breuer, L. and Wagner, P. and Poghossian, Arshak and F{\"o}rster, Arnold and Mang, Thomas and Sch{\"o}ning, Michael Josef},
  title     = {Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films},
  series = {Physica Status Solidi (a)},
  volume    = {209},
  journal   = {Physica Status Solidi (a)},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201100763},
  pages     = {839 -- 845},
  year      = {2012},
  abstract  = {Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3-12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.},
  language  = {en}
}
@misc{BergBesslerGerlachetal.2009,
  author    = {Berg, Gabriele and Bessler, Cornelius and Gerlach, Jochen and G{\"u}bitz, Georg and Heumann, Sonja and Karl, Wolfgang and Maurer, Karl-Heinz and Remler, Peter and Ribitsch, Doris and Schwab, Helmut and Siegert, Petra and Wieland, Susanne},
  title     = {Mittel enthaltend Proteasen aus Stenotrophomonas maltophilia [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / USPTO / WIPO},
  address   = {M{\"u}nchen / Den Hague / Washington / Genf},
  pages     = {1 -- 47},
  year      = {2009},
  language  = {de}
}
@article{ScheerKapelyukhMcEwanetal.2012,
  author    = {Scheer, Nico and Kapelyukh, Yury and McEwan, Jillian and Beuger, Vincent and Stanley, Lesley A. and Rode, Anja and Wolf, C. Roland},
  title     = {Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines},
  series = {Molecular Pharmacology},
  volume    = {81},
  journal   = {Molecular Pharmacology},
  number    = {1},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.111.075192},
  pages     = {63 -- 72},
  year      = {2012},
  abstract  = {The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25\% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.},
  language  = {en}
}