@article{HentschkeHagerHojdis2014,
  author    = {Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils},
  title     = {Molecular Modeling Approach to the Prediction of Mechanical Properties of Silica-Reinforced Rubbers},
  series = {Journal of Applied Polymer Science},
  volume    = {131},
  journal   = {Journal of Applied Polymer Science},
  number    = {18},
  publisher = {Wiley},
  address   = {New York, NY},
  issn      = {1097-4628},
  doi       = {10.1002/app.40806},
  pages     = {1 -- 9},
  year      = {2014},
  abstract  = {Recently, we have suggested a nanomechanical model for dissipative loss in filled elastomer networks in the context of the Payne effect. The mechanism is based on a total interfiller particle force exhibiting an intermittent loop, due to the combination of short-range repulsion and dispersion forces with a long-range elastic attraction. The sum of these forces leads, under external strain, to a spontaneous instability of "bonds" between the aggregates in a filler network and attendant energy dissipation. Here, we use molecular dynamics simulations to obtain chemically realistic forces between surface modified silica particles. The latter are combined with the above model to estimate the loss modulus and the low strain storage modulus in elastomers containing the aforementioned filler-compatibilizer systems. The model is compared to experimental dynamic moduli of silica filled rubbers. We find good agreement between the model predictions and the experiments as function of the compatibilizer's molecular structure and its bulk concentration.},
  language  = {en}
}
@article{LauthHoelderichWagenblast1995,
  author    = {Lauth, Jakob and Hoelderich, W. and Wagenblast, G.},
  title     = {Molecular sieves containing azo dyes},
  series = {Zeolites. 15 (1995), H. 2},
  journal   = {Zeolites. 15 (1995), H. 2},
  isbn      = {0144-2449},
  pages     = {184},
  year      = {1995},
  language  = {en}
}
@misc{LauthHoelderichWagenblast1996,
  author    = {Lauth, Jakob and Hoelderich, Wolfgang and Wagenblast, Gerhard},
  title     = {Molecular sieves containing azo dyes : United States Patent ; patent number 5,573,585 ; date of patent: Nov. 12, 1996 / assignee: Wolfgang Hoelderich. Inventors: Guenter Lauth ; Wolfgang Hoelderich ; Gerhard Wagenblast ...},
  publisher = {[United States Trademark and Patent Office]},
  address   = {[Alexandria, VA]},
  pages     = {15 S. : graph. Darst.},
  year      = {1996},
  language  = {en}
}
@book{LauthHoelderichWagenblast1993,
  author    = {Lauth, Jakob and Hoelderich, Wolfgang and Wagenblast, Gerhard},
  title     = {Molecular sieves containing azo dyes ; Internationale [Pantent]anmeldung WO93/17965 ; Ver{\"o}ffentlichungsdatum: 16.09.1993 / Anmelder: BASF AG},
  publisher = {Weltorganisation f{\"u}r geistiges Eigentum, Internat. B{\"u}ro},
  address   = {[Genf]},
  pages     = {45 S.},
  year      = {1993},
  language  = {en}
}
@article{MeyerHentschkeHageretal.2017,
  author    = {Meyer, Jan and Hentschke, Reinhard and Hager, Jonathan and Hojdis, Nils and Karimi-Varzaneh, Hossein Ali},
  title     = {Molecular Simulation of Viscous Dissipation due to Cyclic Deformation of a Silica-Silica Contact in Filled Rubber},
  series = {Macromolecules},
  volume    = {50},
  journal   = {Macromolecules},
  number    = {17},
  issn      = {1520-5835},
  doi       = {10.1021/acs.macromol.7b00947},
  pages     = {6679 -- 6689},
  year      = {2017},
  language  = {en}
}
@misc{LauthHoelderichWagenblastetal.1993,
  author    = {Lauth, Jakob and H{\"o}lderich, Wolfgang and Wagenblast, Gerhard and Schefczik, Ernst},
  title     = {Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo : Offenlegungsschrift DE4207339A1 ; Ver{\"o}ffentlichungstag im Patentblatt: 16.09.1993 / Anmelder: BASF AG, 67063 Ludwigshafen},
  publisher = {Deutsches Patent- und Markenamt},
  address   = {M{\"u}nchen},
  pages     = {10 S. : Ill.},
  year      = {1993},
  language  = {de}
}
@book{LauthHoelderichWagenblast1994,
  author    = {Lauth, Jakob and Hoelderich, Wolfgang and Wagenblast, Gerhard},
  title     = {Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo = Molecular sieves containing indigo-based dyes ; Europ{\"a}ische Patenanmeldung EP0630353A1 ; Ver{\"o}ffentlichungsdatum 28.12.1994 / Anmelder: BASF AG},
  publisher = {Europ{\"a}isches Patentamt},
  address   = {[M{\"u}nchen u.a.]},
  year      = {1994},
  language  = {de}
}
@book{LauthHoelderichWagenblast1993,
  author    = {Lauth, Jakob and Hoelderich, Wolfgang and Wagenblast, Gerhard},
  title     = {Molekularsiebe, enthaltend Farbstoffe auf Basis von Indigo = Molecular sieves containing indigo-based dyes ; Internationale [Pantent]anmeldung WO 93/17966 ; Ver{\"o}ffentlichungsdatum 16.09.1993 / Anmelder: BASF AG},
  publisher = {Weltorganisation f{\"u}r geistiges Eigentum, Internat. B{\"u}ro},
  address   = {[Genf]},
  pages     = {29 S.},
  year      = {1993},
  language  = {de}
}
@article{MangHaulena1992,
  author    = {Mang, Thomas and Haulena, Friedhelm},
  title     = {Monodisperse latex particles with functional groups},
  series = {Modification of polymers : 4th Dresden Polymer Discussion ; September 22 to 25, 1992 at Gaussig / Dresden University of Technology, Department of Macromolecular Chemistry and Textile Chemistry; Institute of Polymer Technology Dresden. [Organizers: Claudia Kummerl{\"o}we ...]},
  journal   = {Modification of polymers : 4th Dresden Polymer Discussion ; September 22 to 25, 1992 at Gaussig / Dresden University of Technology, Department of Macromolecular Chemistry and Textile Chemistry; Institute of Polymer Technology Dresden. [Organizers: Claudia Kummerl{\"o}we ...]},
  publisher = {Univ.},
  address   = {Dresden},
  pages     = {68 -- 88},
  year      = {1992},
  language  = {en}
}
@misc{LauthTruebenbachHagemeyer1999,
  author    = {Lauth, Jakob and Tr{\"u}benbach, Peter and Hagemeyer, Alfred},
  title     = {Monomodal and polymodal catalyst supports and catalysts having narrow pore size distributions and their production : United States Patent ; patent number 5,935,898 ; date of patent: Aug. 10, 1999 / assignee: BASF Aktiengesellschaft. Inventors: Peter Trubenbach ; Alfred Hagemeyer ; Gunter Lauth ...},
  publisher = {[United States Patent and Trademark Office]},
  address   = {[Alexandria, VA]},
  pages     = {27 S. : graph. Darst.},
  year      = {1999},
  language  = {en}
}
@book{LauthTruebenbachHagemeyer2003,
  author    = {Lauth, Jakob and Tr{\"u}benbach, Peter and Hagemeyer, Alfred},
  title     = {Monomodale und polymodale Katalysatortr{\"a}ger und Katalysatoren mit engen Porengr{\"o}ssenverteilungen und deren Herstellverfahren : Europ{\"a}ische Patentschrift EP0764467B1 ; EP-Patenterteilungsdatum: 05.02.2003 / Anmelder: BASF AG, 67063 Ludwigshafen. Erfinder: Peter Tr{\"u}benbach ; Alfred Hagemeyer ; G{\"u}nter Lauth ...},
  publisher = {Europ{\"a}isches Patentamt},
  address   = {[M{\"u}nchen u.a.]},
  pages     = {33 S. : Ill.},
  year      = {2003},
  language  = {de}
}
@misc{LauthTruebenbachHagemeyeretal.1997,
  author    = {Lauth, Jakob and Tr{\"u}benbach, Peter and Hagemeyer, Alfred and Dingerdissen, Uwe [u.a.]},
  title     = {Monomodale und polymodale Katalysatortr{\"a}ger und Katalysatoren mit engen Porengr{\"o}ßenverteilungen und deren Herstellverfahren : Offenlegungschrift DE19533486A1 ; Ver{\"o}ffentlichungstag im Patentblatt: 13.03.1997 / Anmelder: BASF AG, 67063 Ludwigshafen. Erfinder: Peter Tr{\"u}benbach ; Alfred Hagemeyer ; G{\"u}nter Lauth ...},
  publisher = {Deutsches Patent- und Markenamt},
  address   = {M{\"u}nchen},
  pages     = {38 S. : graph. Darst.},
  year      = {1997},
  language  = {de}
}
@book{LauthTruebenbachHagemeyer2003,
  author    = {Lauth, Jakob and Tr{\"u}benbach, Peter and Hagemeyer, Alfred},
  title     = {Monomodale und polymodale Katalysatortr{\"a}ger und Katalysatoren mit engen Porengr{\"o}ßenverteilungen und deren Herstellverfahren = Monomodal and polymodal catalyst supports and catalysts with a narrow pore size distribution and method for producing the same ; Europ{\"a}ische Patentschrift EP0761307B1 ; Ver{\"o}ffentlichungsdatum 05.02.2003 / Anmelder: BASF Aktiengesellschaft. Erfinder: Peter Tr{\"u}benbach ; Alfred Hagemeyer ; G{\"u}nther Lauth ...},
  publisher = {Europ{\"a}isches Patentamt},
  address   = {[M{\"u}nchen u.a.]},
  pages     = {43 S.},
  year      = {2003},
  language  = {de}
}
@article{AdelsElbersDiehletal.2023,
  author    = {Adels, Klaudia and Elbers, Gereon and Diehl, Bernd and Monakhova, Yulia},
  title     = {Multicomponent analysis of dietary supplements containing glucosamine and chondroitin: comparative low- and high-field NMR spectroscopic study},
  series = {Analytical Sciences},
  volume    = {2023},
  journal   = {Analytical Sciences},
  publisher = {Springer Verlag},
  address   = {Cham},
  issn      = {1348-2246 (Online)},
  doi       = {10.1007/s44211-023-00433-2},
  pages     = {13 Seiten},
  year      = {2023},
  abstract  = {With the prevalence of glucosamine- and chondroitin-containing dietary supplements for people with osteoarthritis in the marketplace, it is important to have an accurate and reproducible analytical method for the quantitation of these compounds in finished products. NMR spectroscopic method based both on low- (80 MHz) and high- (500-600 MHz) field NMR instrumentation was established, compared and validated for the determination of chondroitin sulfate and glucosamine in dietary supplements. The proposed method was applied for analysis of 20 different dietary supplements. In the majority of cases, quantification results obtained on the low-field NMR spectrometer are similar to those obtained with high-field 500-600 MHz NMR devices. Validation results in terms of accuracy, precision, reproducibility, limit of detection and recovery demonstrated that the developed method is fit for purpose for the marketed products. The NMR method was extended to the analysis of methylsulfonylmethane, adulterant maltodextrin, acetate and inorganic ions. Low-field NMR can be a quicker and cheaper alternative to more expensive high-field NMR measurements for quality control of the investigated dietary supplements. High-field NMR instrumentation can be more favorable for samples with complex composition due to better resolution, simultaneously giving the possibility of analysis of inorganic species such as potassium and chloride.},
  language  = {en}
}
@article{MonakhovaDiehl2022,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Multinuclear NMR screening of pharmaceuticals using standardization by 2H integral of a deuterated solvent},
  series = {Journal of Pharmaceutical and Biomedical Analysis},
  volume    = {209},
  journal   = {Journal of Pharmaceutical and Biomedical Analysis},
  number    = {Article number: 114530},
  publisher = {Elsevier},
  isbn      = {0731-7085},
  doi       = {10.1016/j.jpba.2021.114530},
  year      = {2022},
  abstract  = {NMR standardization approach that uses the 2H integral of deuterated solvent for quantitative multinuclear analysis of pharmaceuticals is described. As a proof of principle, the existing NMR procedure for the analysis of heparin products according to US Pharmacopeia monograph is extended to the determination of Na+ and Cl- content in this matrix. Quantification is performed based on the ratio of a 23Na (35Cl) NMR integral and 2H NMR signal of deuterated solvent, D2O, acquired using the specific spectrometer hardware. As an alternative, the possibility of 133Cs standardization using the addition of Cs2CO3 stock solution is shown. Validation characteristics (linearity, repeatability, sensitivity) are evaluated. A holistic NMR profiling of heparin products can now also be used for the quantitative determination of inorganic compounds in a single analytical run using a single sample. In general, the new standardization methodology provides an appealing alternative for the NMR screening of inorganic and organic components in pharmaceutical products.},
  language  = {en}
}
@article{PrielmeierLang1988,
  author    = {Prielmeier, Franz and Lang, E. W.},
  title     = {Multinuclear Spin-Lattice Relaxation Time Studies of Supercooled Aqueous LiCl-Solutions / E .W. Lang, F. X. Prielmeier},
  series = {Berichte der Bunsen-Gesellschaft f{\"u}r Physikalische Chemie. 92 (1988)},
  journal   = {Berichte der Bunsen-Gesellschaft f{\"u}r Physikalische Chemie. 92 (1988)},
  isbn      = {0005-9021},
  pages     = {717},
  year      = {1988},
  language  = {en}
}
@article{SvaneborgKarimiVarzanehHojdisetal.2016,
  author    = {Svaneborg, Carsten and Karimi-Varzaneh, Hossein Ali and Hojdis, Nils and Fleck, Franz and Everaers, Ralf},
  title     = {Multiscale approach to equilibrating model polymer melts},
  series = {Physical Review E},
  volume    = {94},
  journal   = {Physical Review E},
  number    = {032502},
  publisher = {AIP Publishing},
  address   = {Melville, NY},
  issn      = {2470-0053},
  doi       = {10.1103/PhysRevE.94.032502},
  year      = {2016},
  abstract  = {We present an effective and simple multiscale method for equilibrating Kremer Grest model polymer melts of varying stiffness. In our approach, we progressively equilibrate the melt structure above the tube scale, inside the tube and finally at the monomeric scale. We make use of models designed to be computationally effective at each scale. Density fluctuations in the melt structure above the tube scale are minimized through a Monte Carlo simulated annealing of a lattice polymer model. Subsequently the melt structure below the tube scale is equilibrated via the Rouse dynamics of a force-capped Kremer-Grest model that allows chains to partially interpenetrate. Finally the Kremer-Grest force field is introduced to freeze the topological state and enforce correct monomer packing. We generate 15 melts of 500 chains of 10.000 beads for varying chain stiffness as well as a number of melts with 1.000 chains of 15.000 monomers. To validate the equilibration process we study the time evolution of bulk, collective, and single-chain observables at the monomeric, mesoscopic, and macroscopic length scales. Extension of the present method to longer, branched, or polydisperse chains, and/or larger system sizes is straightforward.},
  language  = {en}
}
@article{BaumannGronsfeldSchuetzLembach1997,
  author    = {Baumann, Marcus and Gronsfeld, A. and Sch{\"u}tz-Lembach, G.},
  title     = {Nachdenklichkeit {\"u}ber Nachhaltigkeit : wie uns ein neues Wort alte Probleme neu entdecken l{\"a}ßt},
  series = {Wechselwirkung : Wissenschaft \& vernetztes Denken},
  volume    = {19},
  journal   = {Wechselwirkung : Wissenschaft \& vernetztes Denken},
  number    = {87},
  issn      = {0172-1623},
  pages     = {6 -- 11},
  year      = {1997},
  language  = {de}
}
@book{Selmer1996,
  author    = {Selmer, Thorsten},
  title     = {Nachweis einer neuartigen posttranslationalen Modifikation in Sulfatasen und ihr Fehlen in Enzymen aus Patienten mit multipler Sulfatase-Defizienz},
  publisher = {Cuvillier},
  address   = {G{\"o}ttingen},
  pages     = {XIII, 143, IX S. : graph. Darst.},
  year      = {1996},
  language  = {de}
}
@article{DruckenmuellerGuentherElbers2018,
  author    = {Druckenm{\"u}ller, Katharina and G{\"u}nther, Klaus and Elbers, Gereon},
  title     = {Near-infrared spectroscopy (NIRS) as a tool to monitor exhaust air from poultry operations},
  series = {Science of the Total Environment},
  volume    = {630},
  journal   = {Science of the Total Environment},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0048-9697},
  doi       = {10.1016/j.scitotenv.2018.02.072},
  pages     = {536 -- 543},
  year      = {2018},
  abstract  = {Intensive poultry operation systems emit a considerable volume of inorganic and organic matter in the surrounding environment. Monitoring cleaning properties of exhaust air cleaning systems and to detect small but significant changes in emission characteristics during a fattening cycle is important for both emission and fattening process control. In the present study, we evaluated the potential of near-infrared spectroscopy (NIRS) combined with chemometric techniques as a monitoring tool of exhaust air from poultry operation systems. To generate a high-quality data set for evaluation, the exhaust air of two poultry houses was sampled by applying state-of-the-art filter sampling protocols. The two stables were identical except for one crucial difference, the presence or absence of an exhaust air cleaning system. In total, twenty-one exhaust air samples were collected at the two sites to monitor spectral differences caused by the cleaning device, and to follow changes in exhaust air characteristics during a fattening period. The total dust load was analyzed by gravimetric determination and included as a response variable in multivariate data analysis. The filter samples were directly measured with NIR spectroscopy. Principal component analysis (PCA), linear discriminant analysis (LDA), and factor analysis (FA) were effective in classifying the NIR exhaust air spectra according to fattening day and origin. The results indicate that the dust load and the composition of exhaust air (inorganic or organic matter) substantially influence the NIR spectral patterns. In conclusion, NIR spectroscopy as a tool is a promising and very rapid way to detect differences between exhaust air samples based on still not clearly defined circumstances triggered during a fattening period and the availability of an exhaust air cleaning system.},
  language  = {en}
}
@misc{SiegertWielandEngelskirchenetal.2008,
  author    = {Siegert, Petra and Wieland, Susanne and Engelskirchen, Julia and Merkel, Marion and Maurer, Karl-Heinz and Bessler, Cornelius},
  title     = {Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease [Offenlegungsschrift]},
  publisher = {Deutsches Patentamt / Europ{\"a}isches Patentamt / WIPO},
  address   = {M{\"u}nchen / Den Hague / Genf},
  pages     = {1 -- 51},
  year      = {2008},
  language  = {de}
}
@misc{MerkelWeberSiegertetal.2006,
  author    = {Merkel, Marion and Weber, Angrit and Siegert, Petra and Wieland, Susanne and Maurer, Karl-Heinz and Bessler, Cornelius},
  title     = {Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / WIPO},
  address   = {M{\"u}nchen / Genf},
  pages     = {1 -- 46},
  year      = {2006},
  language  = {de}
}
@article{BiselliJelinekSchmidtetal.2001,
  author    = {Biselli, Manfred and Jelinek, N. and Schmidt, S. and Hilbert, U.},
  title     = {Neue Bioreaktoren zur Kultivierung h{\"a}matopoetischer Zellen / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C.},
  series = {Chemie Ingenieur Technik. 73 (2001), H. 7},
  journal   = {Chemie Ingenieur Technik. 73 (2001), H. 7},
  isbn      = {0009-286X},
  pages     = {894 -- 898},
  year      = {2001},
  language  = {de}
}
@book{Berndt2014,
  author    = {Berndt, Heinz},
  title     = {Neue Kondensations-Methoden zur Synthese definierter Peptid-Derivate},
  address   = {Aachen},
  pages     = {XII, VI, 207 S. : graph. Darst.},
  year      = {2014},
  language  = {de}
}
@misc{SiegertMerkelKluinetal.2011,
  author    = {Siegert, Petra and Merkel, Marion and Kluin, Cornelia and Maurer, Karl-Heinz and O'Connell, Timothy and Wieland, Susanne and Hellmuth, Hendrik},
  title     = {Neue Proteasen und diese enthaltende Mittel [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO},
  address   = {M{\"u}nchen / Den Hague / Genf},
  pages     = {1 -- 21},
  year      = {2011},
  language  = {de}
}
@misc{SiegertMussmannO'Connelletal.2010,
  author    = {Siegert, Petra and Mussmann, Nina and O'Connell, Timothy and Maurer, Karl-Heinz},
  title     = {Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / WIPO},
  address   = {M{\"u}nchen / Genf},
  pages     = {1 -- 30},
  year      = {2010},
  language  = {de}
}
@misc{SiegertBaumstarkKluinetal.2010,
  author    = {Siegert, Petra and Baumstark, Rebecca and Kluin, Cornelia and O'Connell, Timothy and Maurer, Karl-Heinz and Hellmuth, Hendrik},
  title     = {Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt},
  address   = {M{\"u}nchen},
  pages     = {1 -- 30},
  year      = {2010},
  language  = {de}
}
@misc{SiegertSpitzMaurer2010,
  author    = {Siegert, Petra and Spitz, Astrid and Maurer, Karl-Heinz},
  title     = {Neue Proteasen und Mittel enthaltend diese Proteasen [Offenlegungsschrift]},
  publisher = {Deutsches Patentamt / WIPO},
  address   = {M{\"u}nchen / Genf},
  pages     = {1 -- 31},
  year      = {2010},
  language  = {de}
}
@misc{JerominMang2005,
  author    = {Jeromin, G{\"u}nter Erich and Mang, Thomas},
  title     = {Neue Technik mit magnetisierbaren Materialien : Offenlegungsschrift DE102004005201A1 ; Offenlegungstag: 11.08.2005},
  publisher = {Deutsches Patent- und Markenamt},
  address   = {M{\"u}nchen},
  pages     = {8 S.},
  year      = {2005},
  language  = {de}
}
@misc{JerominSchwarzer2008,
  author    = {Jeromin, G{\"u}nter Erich and Schwarzer, Klemens},
  title     = {Neuer W{\"a}rmetr{\"a}ger f{\"u}r Solaranlagen : Offenlegungsschrift : DE 102007016738 A1 ; Offenlegungstag: 09.10.2008},
  publisher = {Deutsches Patent- und Markenamt},
  address   = {M{\"u}nchen},
  pages     = {8 S.},
  year      = {2008},
  language  = {de}
}
@article{SelmerPierikHeider2005,
  author    = {Selmer, Thorsten and Pierik, Antonio J. and Heider, Johann},
  title     = {New glycyl radical enzymes catalysing key metabolic steps in anaerobic bacteria},
  series = {Biological Chemistry. 386 (2005), H. 10},
  journal   = {Biological Chemistry. 386 (2005), H. 10},
  isbn      = {1431-6730},
  pages     = {981 -- 988},
  year      = {2005},
  language  = {en}
}
@article{SchererKratzGoberetal.1992,
  author    = {Scherer, Ulrich W. and Kratz, J. V. and Gober, M. K. and Zimmermann, H. P.},
  title     = {New nuclide 263 105 / J.V. Kratz, M.K. Gober, H.P. Zimmermann, M. Sch{\"a}del, W. Br{\"u}chle, E. Schimpf, K.E. Gregorich, A. T{\"u}rler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M.J. Nurmia, D.C. Hoffman, H. G{\"a}ggeler, D. Jost, U.W. Scherer, A. Weber},
  series = {Physical Review C . 45 (1992)},
  journal   = {Physical Review C . 45 (1992)},
  pages     = {1064 -- 1069},
  year      = {1992},
  language  = {en}
}
@article{FalkenbergVossBottetal.2023,
  author    = {Falkenberg, Fabian and Voß, Leonie and Bott, Michael and Bongaerts, Johannes and Siegert, Petra},
  title     = {New robust subtilisins from halotolerant and halophilic Bacillaceae},
  series = {Applied Microbiology and Biotechnology},
  volume    = {107},
  journal   = {Applied Microbiology and Biotechnology},
  publisher = {Springer Nature},
  address   = {Berlin},
  issn      = {1432-0614},
  doi       = {10.1007/s00253-023-12553-w},
  pages     = {3939 -- 3954},
  year      = {2023},
  abstract  = {The aim of the present study was the characterisation of three true subtilisins and one phylogenetically intermediate subtilisin from halotolerant and halophilic microorganisms. Considering the currently growing enzyme market for efficient and novel biocatalysts, data mining is a promising source for novel, as yet uncharacterised enzymes, especially from halophilic or halotolerant Bacillaceae, which offer great potential to meet industrial needs. Both halophilic bacteria Pontibacillus marinus DSM 16465ᵀ and Alkalibacillus haloalkaliphilus DSM 5271ᵀ and both halotolerant bacteria Metabacillus indicus DSM 16189 and Litchfieldia alkalitelluris DSM 16976ᵀ served as a source for the four new subtilisins SPPM, SPAH, SPMI and SPLA. The protease genes were cloned and expressed in Bacillus subtilis DB104. Purification to apparent homogeneity was achieved by ethanol precipitation, desalting and ion-exchange chromatography. Enzyme activity could be observed between pH 5.0-12.0 with an optimum for SPPM, SPMI and SPLA around pH 9.0 and for SPAH at pH 10.0. The optimal temperature for SPMI and SPLA was 70 °C and for SPPM and SPAH 55 °C and 50 °C, respectively. All proteases showed high stability towards 5\% (w/v) SDS and were active even at NaCl concentrations of 5 M. The four proteases demonstrate potential for future biotechnological applications.},
  language  = {en}
}
@article{ThielTippkoetterSucketal.2013,
  author    = {Thiel, Alexander and Tippk{\"o}tter, Nils and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland},
  title     = {New zeolite adsorbents for downstream processing of polyphenols from renewable resources},
  series = {Engineering in Life Sciences},
  volume    = {13},
  journal   = {Engineering in Life Sciences},
  number    = {3},
  publisher = {Wiley},
  address   = {Weinheim},
  doi       = {10.1002/elsc.201200188},
  pages     = {239 -- 246},
  year      = {2013},
  abstract  = {Commercial materials with polyvinylpolypyrrolidone and polymeric amberlites (XAD7HP, XAD16) are commonly used for the adsorptive downstream processing of polyphenols from renewable resources. In this study, beta-zeolite-based adsorbent systems were examined, and their properties were compared to organic resins. Batch adsorption experiments were conducted with synthetic solutions of major polyphenols. Adsorption isotherms and desorption characteristics of individual adsorbent were determined based on these results. Maximum adsorption capacities were calculated using the Langmuir model. For example, the zeolites had capacities up to 203.2 mg/g for ferulic acid. To extend these results to a complex system, additional experiments were performed on rapeseed meal and wheat seed extracts as representative renewable resources. HPLC analysis showed that with 7.5\% w/v, which is regarded as the optimum amount of zeolites, zeolites A and B could bind 100\% of the major polyphenols as well as release polyphenols at high yields. Additionally, regeneration experiments were performed with isopropyl alcohol at 99°C to evaluate how zeolites regenerate under mild conditions. The results showed only a negligible loss of adsorption capacity and no loss of desorption capacity. In summary, it was concluded that beta-zeolites were promising adsorbents for developing new processes to isolate polyphenols from renewable resources.},
  language  = {en}
}
@misc{JerominSeubertBeilharzetal.1988,
  author    = {Jeromin, G{\"u}nter Erich and Seubert, Bernhard and Beilharz, Helmut and Fickert, Werner [u.a.]},
  title     = {Niedermolekulare Alkalihuminate : Verfahren zu ihrer Herstellung und Verwendung ; Offenlegungsschrift DE3707909A1 ; Offenlegungstag: 22.09.1988 / Anmelder: R{\"u}tgerswerke AG, 6000 Frankfurt. Erfinder: Bernhard Seubert ; Helmut Beilharz ; Werner Fickert ; G{\"u}nter Jeromin ...},
  publisher = {Deutsches Patent- und Markenamt},
  address   = {M{\"u}nchen},
  pages     = {4 S.},
  year      = {1988},
  language  = {de}
}
@misc{JerominSeubertBeilharzetal.1991,
  author    = {Jeromin, G{\"u}nter Erich and Seubert, Bernhard and Beilharz, Helmut and Fickert, Werner [u.a.]},
  title     = {Niedermolekulare Alkalihuminate : Verfahren zur ihrer Herstellung und Verwendung ; Europ{\"a}ische Patentschrift EP0281679B1 ; Ver{\"o}ffentlichungstag im Patentblatt: 01.08.1991 / Anmelder: R{\"u}tgerswerke AG, 6000 Frankfurt. Erfinder: Bernhard Seubert ; Helmut Beilharz ; G{\"u}nter Jeromin ; Werner Fickert ...},
  publisher = {Deutsches Patent- und Markenamt},
  address   = {M{\"u}nchen},
  pages     = {7 S.},
  year      = {1991},
  language  = {de}
}
@article{ElbersGaebHoffmannetal.2006,
  author    = {Elbers, Gereon and G{\"a}b, Martina and Hoffmann, Katharina and Lobe, Melanie},
  title     = {NIR-spectroscopic investigation of foliage of ozone-stressed Fagus sylvatica trees / G{\"a}b, Martina ; Hoffmann, Katharina ; Lobe, Melanie ; Metzger, Rut ; Ooyen, Sven van ; Elbers, Gereon ; K{\"o}llner, Barbara},
  series = {Journal of Forest Research. 11 (2006), H. 2},
  journal   = {Journal of Forest Research. 11 (2006), H. 2},
  isbn      = {1341-6979},
  pages     = {69 -- 75},
  year      = {2006},
  language  = {en}
}
@article{TippkoetterRoikaewUlber2008,
  author    = {Tippk{\"o}tter, Nils and Roikaew, W. and Ulber, R.},
  title     = {Nitrate removal from whey concentrate with biotechnological regeneration of the waste water},
  series = {European dairy magazine : EDM},
  journal   = {European dairy magazine : EDM},
  number    = {1},
  isbn      = {0936-6318},
  pages     = {30 -- 32},
  year      = {2008},
  language  = {en}
}
@article{TippkoetterRoikaewUlber2007,
  author    = {Tippk{\"o}tter, Nils and Roikaew, N. and Ulber, R.},
  title     = {Nitratentfernung aus Molkekonzentrat mit biotechnologischer Regeneration der Abw{\"a}sser},
  series = {Deutsche Milchwirtschaft},
  volume    = {58},
  journal   = {Deutsche Milchwirtschaft},
  number    = {15},
  issn      = {0012-0480},
  pages     = {540 -- 542},
  year      = {2007},
  language  = {de}
}
@article{UlberTippkoetter2009,
  author    = {Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Nitratfreie Molke},
  series = {Rundschau f{\"u}r Fleischhygiene und Lebensmittel{\"u}berwachung},
  journal   = {Rundschau f{\"u}r Fleischhygiene und Lebensmittel{\"u}berwachung},
  number    = {4},
  pages     = {150 -- 152},
  year      = {2009},
  language  = {de}
}
@article{BrabandPaulssenAbram2006,
  author    = {Braband, Henrik and Paulßen, Elisabeth and Abram, Ulrich},
  title     = {Nitridorhenium(V) Complexes with 1,3-Dialkyl-4,5-dimethylimidazole-2-ylidenes},
  series = {Zeitschrift f{\"u}r anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry},
  volume    = {632},
  journal   = {Zeitschrift f{\"u}r anorganische und allgemeine Chemie : ZAAC = Journal of inorganic and general chemistry},
  number    = {6},
  issn      = {1521-3749},
  doi       = {10.1002/zaac.200600002},
  pages     = {1051 -- 1056},
  year      = {2006},
  language  = {en}
}
@article{BaumannSemenehDehairsetal.1998,
  author    = {Baumann, Marcus and Semeneh, M. and Dehairs, F. and Elskens, M.},
  title     = {Nitrogen uptake regime and phytoplankton community structure in the Southern Ocean / Semeneh, M. ; Dehairs, F. ; Elskens, M. ; Baumann, M.E.M. ; Kopczynska, E.E. ; Lancelot, C. ; Goeyens, L.},
  series = {Journal of Marine Systems. 17 (1998), H. 1-4},
  journal   = {Journal of Marine Systems. 17 (1998), H. 1-4},
  isbn      = {0924-7963},
  pages     = {159 -- 177},
  year      = {1998},
  language  = {en}
}
@article{KotterGregerIhme1984,
  author    = {Kotter, Michael and Greger, M. and Ihme, B.},
  title     = {Nonequilibrium phase transitions with hysteresis in solid catalysts : the system copper-oxygen-propene / M. Greger ; B. Ihme ; M. Kotter ...},
  series = {Berichte der Bunsen-Gesellschaft f{\"u}r Physikalische Chemie. 88 (1984)},
  journal   = {Berichte der Bunsen-Gesellschaft f{\"u}r Physikalische Chemie. 88 (1984)},
  isbn      = {0005-9021},
  pages     = {427 -- 433},
  year      = {1984},
  language  = {en}
}
@article{LawsonScheerPhametal.2001,
  author    = {Lawson, Nathan D. and Scheer, Nico and Pham, Van N. and Kim, Ceol-Hee and Chitnis, Ajay B. and Campos-Ortega, Jos{\´e} A. and Weinstein, Brant M.},
  title     = {Notch signaling is required for arterial-venous differentiation during embryonic vascular development},
  series = {Development},
  volume    = {128},
  journal   = {Development},
  number    = {19},
  issn      = {1477-9129},
  pages     = {3675 -- 3683},
  year      = {2001},
  language  = {en}
}
@article{HaegerProbstJaegeretal.2023,
  author    = {Haeger, Gerrit and Probst, Johanna and Jaeger, Karl-Erich and Bongaerts, Johannes and Siegert, Petra},
  title     = {Novel aminoacylases from Streptomyces griseus DSM 40236 and their recombinant production in Streptomyces lividans},
  series = {FEBS Open Bio},
  volume    = {13},
  journal   = {FEBS Open Bio},
  number    = {12},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {2211-5463},
  doi       = {10.1002/2211-5463.13723},
  pages     = {2224 -- 2238},
  year      = {2023},
  abstract  = {Amino acid-based surfactants are valuable compounds for cosmetic formulations. The chemical synthesis of acyl-amino acids is conventionally performed by the Schotten-Baumann reaction using fatty acyl chlorides, but aminoacylases have also been investigated for use in biocatalytic synthesis with free fatty acids. Aminoacylases and their properties are diverse; they belong to different peptidase families and show differences in substrate specificity and biocatalytic potential. Bacterial aminoacylases capable of synthesis have been isolated from Burkholderia, Mycolicibacterium, and Streptomyces. Although several proteases and peptidases from S. griseus have been described, no aminoacylases from this species have been identified yet. In this study, we investigated two novel enzymes produced by S. griseus DSM 40236ᵀ . We identified and cloned the respective genes and recombinantly expressed an α-aminoacylase (EC 3.5.1.14), designated SgAA, and an ε-lysine acylase (EC 3.5.1.17), designated SgELA, in S. lividans TK23. The purified aminoacylase SgAA was biochemically characterized, focusing on its hydrolytic activity to determine temperature- and pH optima and stabilities. The aminoacylase could hydrolyze various acetyl-amino acids at the Nα -position with a broad specificity regarding the sidechain. Substrates with longer acyl chains, like lauroyl-amino acids, were hydrolyzed to a lesser extent. Purified aminoacylase SgELA specific for the hydrolysis of Nε -acetyl-L-lysine was unstable and lost its enzymatic activity upon storage for a longer period but could initially be characterized. The pH optimum of SgELA was pH 8.0. While synthesis of acyl-amino acids was not observed with SgELA, SgAA catalyzed the synthesis of lauroyl-methionine.},
  language  = {en}
}
@article{MonakhovaDiehl2021,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard},
  series = {Talanta},
  volume    = {222},
  journal   = {Talanta},
  number    = {Article number: 121504},
  publisher = {Elsevier},
  isbn      = {0039-9140},
  doi       = {10.1016/j.talanta.2020.121504},
  year      = {2021},
  abstract  = {Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated. In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).},
  language  = {en}
}
@article{BiselliJelinekSchmidtetal.2002,
  author    = {Biselli, Manfred and Jelinek, N. and Schmidt, S. and Hilbert, U.},
  title     = {Novel bioreactors for the ex vivo cultivation of hematopoietic cells / Jelinek, N. ; Schmidt, S. ; Hilbert, U. ; Thoma, S. ; Biselli, M. ; Wandrey, C.},
  series = {Engineering in Life Sciences. 2 (2002), H. 1},
  journal   = {Engineering in Life Sciences. 2 (2002), H. 1},
  isbn      = {1618-0240},
  pages     = {15 -- 18},
  year      = {2002},
  language  = {en}
}
@article{SelmerJennemannBaueretal.1999,
  author    = {Selmer, Thorsten and Jennemann, Richard and Bauer, Bernhard L. and Bertalanffy, Helmut},
  title     = {Novel glycoinositolphosphosphingolipids, basidiolipids, from Agaricus / Jennemann, Richard ; Bauer, Bernhard, L. ; Bertalanffy, Helmut ; Geyer, Rudolf ; Gschwind, Ruth, M. ; Selmer, Thorsten ; Wiegandt, Herbert},
  series = {European Journal of Biochemistry. 259 (1999), H. 1-2},
  journal   = {European Journal of Biochemistry. 259 (1999), H. 1-2},
  isbn      = {0014-2956},
  pages     = {331 -- 338},
  year      = {1999},
  language  = {en}
}
@article{MonakhovaDiehl2022,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Nuclear magnetic resonance spectroscopy as an elegant tool for a complete quality control of crude heparin material},
  series = {Journal of Pharmaceutical and Biomedical Analysis},
  volume    = {219},
  journal   = {Journal of Pharmaceutical and Biomedical Analysis},
  number    = {Article number: 114915},
  publisher = {Elsevier},
  address   = {New York, NY},
  issn      = {0731-7085},
  doi       = {10.1016/j.jpba.2022.114915},
  year      = {2022},
  abstract  = {Nuclear magnetic resonance (NMR) spectrometric methods for the quantitative analysis of pure heparin in crude heparin is proposed. For quantification, a two-step routine was developed using a USP heparin reference sample for calibration and benzoic acid as an internal standard. The method was successfully validated for its accuracy, reproducibility, and precision. The methodology was used to analyze 20 authentic porcine heparinoid samples having heparin content between 4.25 w/w \% and 64.4 w/w \%. The characterization of crude heparin products was further extended to a simultaneous analysis of these common ions: sodium, calcium, acetate and chloride. A significant, linear dependence was found between anticoagulant activity and assayed heparin content for thirteen heparinoids samples, for which reference data were available. A Diffused-ordered NMR experiment (DOSY) can be used for qualitative analysis of specific glycosaminoglycans (GAGs) in heparinoid matrices and, potentially, for quantitative prediction of molecular weight of GAGs. NMR spectrometry therefore represents a unique analytical method suitable for the simultaneous quantitative control of organic and inorganic composition of crude heparin samples (especially heparin content) as well as an estimation of other physical and quality parameters (molecular weight, animal origin and activity).},
  language  = {en}
}
@article{StanleyHorsburghRossetal.2006,
  author    = {Stanley, Lesley A. and Horsburgh, Brian C. and Ross, Jillian and Scheer, Nico and Wolf, C. Roland},
  title     = {Nuclear Receptors which play a pivotal role in drug disposition and chemical toxicity},
  series = {Drug Metabolism Reviews},
  volume    = {38},
  journal   = {Drug Metabolism Reviews},
  number    = {3},
  issn      = {1097-9883},
  doi       = {10.1080/03602530600786232},
  pages     = {515 -- 597},
  year      = {2006},
  language  = {en}
}