@inproceedings{KohlSchmidtsKloeseretal.2021,
  author    = {Kohl, Philipp and Schmidts, Oliver and Kl{\"o}ser, Lars and Werth, Henri and Kraft, Bodo and Z{\"u}ndorf, Albert},
  title     = {STAMP 4 NLP - an agile framework for rapid quality-driven NLP applications development},
  series = {Quality of Information and Communications Technology. QUATIC 2021},
  booktitle = {Quality of Information and Communications Technology. QUATIC 2021},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-85346-4},
  doi       = {10.1007/978-3-030-85347-1_12},
  pages     = {156 -- 166},
  year      = {2021},
  abstract  = {The progress in natural language processing (NLP) research over the last years, offers novel business opportunities for companies, as automated user interaction or improved data analysis. Building sophisticated NLP applications requires dealing with modern machine learning (ML) technologies, which impedes enterprises from establishing successful NLP projects. Our experience in applied NLP research projects shows that the continuous integration of research prototypes in production-like environments with quality assurance builds trust in the software and shows convenience and usefulness regarding the business goal. We introduce STAMP 4 NLP as an iterative and incremental process model for developing NLP applications. With STAMP 4 NLP, we merge software engineering principles with best practices from data science. Instantiating our process model allows efficiently creating prototypes by utilizing templates, conventions, and implementations, enabling developers and data scientists to focus on the business goals. Due to our iterative-incremental approach, businesses can deploy an enhanced version of the prototype to their software environment after every iteration, maximizing potential business value and trust early and avoiding the cost of successful yet never deployed experiments.},
  language  = {en}
}
@inproceedings{SchmidtsKraftWinkensetal.2021,
  author    = {Schmidts, Oliver and Kraft, Bodo and Winkens, Marvin and Z{\"u}ndorf, Albert},
  title     = {Catalog integration of heterogeneous and volatile product data},
  series = {DATA 2020: Data Management Technologies and Applications},
  booktitle = {DATA 2020: Data Management Technologies and Applications},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-83013-7},
  doi       = {10.1007/978-3-030-83014-4_7},
  pages     = {134 -- 153},
  year      = {2021},
  abstract  = {The integration of frequently changing, volatile product data from different manufacturers into a single catalog is a significant challenge for small and medium-sized e-commerce companies. They rely on timely integrating product data to present them aggregated in an online shop without knowing format specifications, concept understanding of manufacturers, and data quality. Furthermore, format, concepts, and data quality may change at any time. Consequently, integrating product catalogs into a single standardized catalog is often a laborious manual task. Current strategies to streamline or automate catalog integration use techniques based on machine learning, word vectorization, or semantic similarity. However, most approaches struggle with low-quality or real-world data. We propose Attribute Label Ranking (ALR) as a recommendation engine to simplify the integration process of previously unknown, proprietary tabular format into a standardized catalog for practitioners. We evaluate ALR by focusing on the impact of different neural network architectures, language features, and semantic similarity. Additionally, we consider metrics for industrial application and present the impact of ALR in production and its limitations.},
  language  = {en}
}
@inproceedings{GrundmannBorellaCeriottietal.2021,
  author    = {Grundmann, Jan Thimo and Borella, Laura and Ceriotti, Matteo and Chand, Suditi and Cordero, Federico and Dachwald, Bernd and Fexer, Sebastian and Grimm, Christian D. and Hendrikse, Jeffrey and Herč{\´i}k, David and Herique, Alain and Hillebrandt, Martin and Ho, Tra-Mi and Kesseler, Lars and Laabs, Martin and Lange, Caroline and Lange, Michael and Lichtenheldt, Roy and McInnes, Colin R. and Moore, Iain and Peloni, Alessandro and Plettenmeier, Dirk and Quantius, Dominik and Seefeldt, Patric and Venditti, Flaviane c. F. and Vergaaij, Merel and Viavattene, Giulia and Virkki, Anne K. and Zander, Martin},
  title     = {More bucks for the bang: new space solutions, impact tourism and one unique science \& engineering opportunity at T-6 months and counting},
  series = {7th IAA Planetary Defense Conference},
  booktitle = {7th IAA Planetary Defense Conference},
  year      = {2021},
  abstract  = {For now, the Planetary Defense Conference Exercise 2021's incoming fictitious(!), asteroid, 2021 PDC, seems headed for impact on October 20th, 2021, exactly 6 months after its discovery. Today (April 26th, 2021), the impact probability is 5\%, in a steep rise from 1 in 2500 upon discovery six days ago. We all know how these things end. Or do we? Unless somebody kicked off another headline-grabbing media scare or wants to keep civil defense very idle very soon, chances are that it will hit (note: this is an exercise!). Taking stock, it is barely 6 months to impact, a steadily rising likelihood that it will actually happen, and a huge uncertainty of possible impact energies: First estimates range from 1.2 MtTNT to 13 GtTNT, and this is not even the worst-worst case: a 700 m diameter massive NiFe asteroid (covered by a thin veneer of Ryugu-black rubble to match size and brightness), would come in at 70 GtTNT. In down to Earth terms, this could be all between smashing fireworks over some remote area of the globe and a 7.5 km crater downtown somewhere. Considering the deliberate and sedate ways of development of interplanetary missions it seems we can only stand and stare until we know well enough where to tell people to pack up all that can be moved at all and save themselves. But then, it could just as well be a smaller bright rock. The best estimate is 120 m diameter from optical observation alone, by 13\% standard albedo. NASA's upcoming DART mission to binary asteroid (65803) Didymos is designed to hit such a small target, its moonlet Dimorphos. The Deep Impact mission's impactor in 2005 successfully guided itself to the brightest spot on comet 9P/Tempel 1, a relatively small feature on the 6 km nucleus. And 'space' has changed: By the end of this decade, one satellite communication network plans to have launched over 11000 satellites at a pace of 60 per launch every other week. This level of series production is comparable in numbers to the most prolific commercial airliners. Launch vehicle production has not simply increased correspondingly - they can be reused, although in a trade for performance. Optical and radio astronomy as well as planetary radar have made great strides in the past decade, and so has the design and production capability for everyday 'high-tech' products. 60 years ago, spaceflight was invented from scratch within two years, and there are recent examples of fast-paced space projects as well as a drive towards 'responsive space'. It seems it is not quite yet time to abandon all hope. We present what could be done and what is too close to call once thinking is shoved out of the box by a clear and present danger, to show where a little more preparedness or routine would come in handy - or become decisive. And if we fail, let's stand and stare safely and well instrumented anywhere on Earth together in the greatest adventure of science.},
  language  = {en}
}
@inproceedings{MertensPuetzBrauneretal.2021,
  author    = {Mertens, Alexander and P{\"u}tz, Sebastian and Brauner, Philipp and Brillowski, Florian Sascha and Buczak, Nadine and Dammers, Hannah and van Dyck, Marc and Kong, Iris and K{\"o}nigs, Peter and Kortomeikel, Frauke Carole and Rodemann, Niklas and Schaar, Anne Kathrin and Steuer-Dankert, Linda and Wlecke, Shari and Gries, Thomas and Leicht-Scholten, Carmen and Nagel, Saskia K. and Piller, Frank Thomas and Schuh, G{\"u}nther and Ziefle, Martina and Nitsch, Verena},
  title     = {Human digital shadow: Data-based modeling of users and usage in the internet of production},
  series = {14th International Conference on Human System Interaction : 8-10 July 2021. Gdańsk, Poland},
  booktitle = {14th International Conference on Human System Interaction : 8-10 July 2021. Gdańsk, Poland},
  publisher = {IEEE},
  doi       = {10.1109/HSI52170.2021.9538729},
  pages     = {1 -- 8},
  year      = {2021},
  abstract  = {Digital Shadows as the aggregation, linkage and abstraction of data relating to physical objects are a central vision for the future of production. However, the majority of current research takes a technocentric approach, in which the human actors in production play a minor role. Here, the authors present an alternative anthropocentric perspective that highlights the potential and main challenges of extending the concept of Digital Shadows to humans. Following future research methodology, three prospections that illustrate use cases for Human Digital Shadows across organizational and hierarchical levels are developed: human-robot collaboration for manual work, decision support and work organization, as well as human resource management. Potentials and challenges are identified using separate SWOT analyses for the three prospections and common themes are emphasized in a concluding discussion.},
  language  = {en}
}
@article{DickhoffHorikawaFunke2021,
  author    = {Dickhoff, Jens and Horikawa, Atsushi and Funke, Harald},
  title     = {Hydrogen Combustion - new DLE Combustor Addresses NOx Emissions and Flashback},
  series = {Turbomachinery international : the global journal of energy equipment},
  volume    = {62},
  journal   = {Turbomachinery international : the global journal of energy equipment},
  number    = {4},
  publisher = {MJH Life Sciences},
  address   = {Cranbury},
  issn      = {2767-2328},
  pages     = {26 -- 27},
  year      = {2021},
  language  = {en}
}
@article{WeldenJablonskiWegeetal.2021,
  author    = {Welden, Rene and Jablonski, Melanie and Wege, Christina and Keusgen, Michael and Wagner, Patrick Hermann and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase},
  series = {Biosensors},
  volume    = {11},
  journal   = {Biosensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-6374},
  doi       = {10.3390/bios11060171},
  pages     = {Artikel 171},
  year      = {2021},
  abstract  = {The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte's pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS.},
  language  = {en}
}
@inproceedings{ButenwegMarinkovićPaveseetal.2021,
  author    = {Butenweg, Christoph and Marinković, Marko and Pavese, Alberto and Lanese, Igor and Hoffmeister, Benno and Pinkawa, Marius and Vulcu, Mihai-Cristian and Bursi, Oreste and Nardin, Chiara and Paolacci, Fabrizio and Quinci, Gianluca and Fragiadakis, Michalis and Weber, Felix and Huber, Peter and Renault, Philippe and G{\"u}ndel, Max and Dyke, Shirley and Ciucci, M. and Marino, A.},
  title     = {Seismic performance of multi-component systems in special risk industrial facilities},
  series = {17. World Conference on Earthquake Engineering , Sendai , Japan , 17WCEE , 2021-09-27 - 2021-10-02},
  booktitle = {17. World Conference on Earthquake Engineering , Sendai , Japan , 17WCEE , 2021-09-27 - 2021-10-02},
  year      = {2021},
  abstract  = {Past earthquakes demonstrated the high vulnerability of industrial facilities equipped with complex process technologies leading to serious damage of the process equipment and multiple and simultaneous release of hazardous substances in industrial facilities. Nevertheless, the design of industrial plants is inadequately described in recent codes and guidelines, as they do not consider the dynamic interaction between the structure and the installations and thus the effect of seismic response of the installations on the response of the structure and vice versa. The current code-based approach for the seismic design of industrial facilities is considered not enough for ensure proper safety conditions against exceptional event entailing loss of content and related consequences. Accordingly, SPIF project (Seismic Performance of Multi- Component Systems in Special Risk Industrial Facilities) was proposed within the framework of the European H2020 - SERA funding scheme (Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe). The objective of the SPIF project is the investigation of the seismic behavior of a representative industrial structure equipped with complex process technology by means of shaking table tests. The test structure is a three-story moment resisting steel frame with vertical and horizontal vessels and cabinets, arranged on the three levels and connected by pipes. The dynamic behavior of the test structure and installations is investigated with and without base isolation. Furthermore, both firmly anchored and isolated components are taken into account to compare their dynamic behavior and interactions with each other. Artificial and synthetic ground motions are applied to study the seismic response at different PGA levels. After each test, dynamic identification measurements are carried out to characterize the system condition. The contribution presents the numerical simulations to calibrate the tests on the prototype, the experimental setup of the investigated structure and installations, selected measurement data and finally describes preliminary experimental results.},
  language  = {en}
}
@inproceedings{NeumannAdamBackesetal.2021,
  author    = {Neumann, Hannah and Adam, Mario and Backes, Klaus and B{\"o}rner, Martin and Clees, Tanja and Doetsch, Christian and Glaeser, Susanne and Herrmann, Ulf and May, Johanna and Rosenthal, Florian and Sauer, Dirk Uwe and Stadler, Ingo},
  title     = {Development of open educational resources for renewable energy and the energy transition process},
  series = {ISES SWC 2021},
  booktitle = {ISES SWC 2021},
  publisher = {International Solar Energy Society},
  address   = {Freiburg},
  doi       = {10.18086/swc.2021.47.03},
  pages     = {6 Seiten},
  year      = {2021},
  abstract  = {The dissemination of knowledge about renewable energies is understood as a social task with the highest topicality. The transfer of teaching content on renewable energies into digital open educational resources offers the opportunity to significantly accelerate the implementation of the energy transition. Thus, in the here presented project six German universities create open educational resources for the energy transition. These materials are available to the public on the internet under a free license. So far there has been no publicly accessible, editable media that cover entire learning units about renewable energies extensively and in high technical quality. Thus, in this project, the content that remains up-to-date for a longer period is appropriately prepared in terms of media didactics. The materials enable lecturers to provide students with in-depth training about technologies for the energy transition. In a particular way, the created material is also suitable for making the general public knowledgeable about the energy transition with scientifically based material.},
  language  = {en}
}
@article{CapitainWagnerHummeletal.2021,
  author    = {Capitain, Charlotte and Wagner, Sebastian and Hummel, Joana and Tippk{\"o}tter, Nils},
  title     = {Investigation of C-N Formation Between Catechols and Chitosan for the Formation of a Strong, Novel Adhesive Mimicking Mussel Adhesion},
  series = {Waste and Biomass Valorization},
  volume    = {12},
  journal   = {Waste and Biomass Valorization},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1877-265X},
  doi       = {10.1007/s12649-020-01110-5},
  pages     = {1761 -- 1779},
  year      = {2021},
  language  = {en}
}
@article{FaganBitzBjoerkmanBurtscheretal.2021,
  author    = {Fagan, Andrew J. and Bitz, Andreas and Bj{\"o}rkman-Burtscher, Isabella M. and Collins, Christopher M. and Kimbrell, Vera and Raaijmakers, Alexander J. E.},
  title     = {7T MR Safety},
  series = {Journal of Magnetic Resonance Imaging (JMRI)},
  volume    = {53},
  journal   = {Journal of Magnetic Resonance Imaging (JMRI)},
  number    = {2},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1522-2586},
  doi       = {10.1002/jmri.27319},
  pages     = {333 -- 346},
  year      = {2021},
  language  = {en}
}
@article{BlankeHagenkampDoeringetal.2021,
  author    = {Blanke, Tobias and Hagenkamp, Markus and D{\"o}ring, Bernd and G{\"o}ttsche, Joachim and Reger, Vitali and Kuhnhenne, Markus},
  title     = {Net-exergetic, hydraulic and thermal optimization of coaxial heat exchangers using fixed flow conditions instead of fixed flow rates},
  series = {Geothermal Energy},
  volume    = {9},
  journal   = {Geothermal Energy},
  number    = {Article number: 19},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2195-9706},
  doi       = {10.1186/s40517-021-00201-3},
  pages     = {23 Seiten},
  year      = {2021},
  abstract  = {Previous studies optimized the dimensions of coaxial heat exchangers using constant mass fow rates as a boundary condition. They show a thermal optimal circular ring width of nearly zero. Hydraulically optimal is an inner to outer pipe radius ratio of 0.65 for turbulent and 0.68 for laminar fow types. In contrast, in this study, fow conditions in the circular ring are kept constant (a set of fxed Reynolds numbers) during optimization. This approach ensures fxed fow conditions and prevents inappropriately high or low mass fow rates. The optimization is carried out for three objectives: Maximum energy gain, minimum hydraulic efort and eventually optimum net-exergy balance. The optimization changes the inner pipe radius and mass fow rate but not the Reynolds number of the circular ring. The thermal calculations base on Hellstr{\"o}m's borehole resistance and the hydraulic optimization on individually calculated linear loss of head coefcients. Increasing the inner pipe radius results in decreased hydraulic losses in the inner pipe but increased losses in the circular ring. The net-exergy diference is a key performance indicator and combines thermal and hydraulic calculations. It is the difference between thermal exergy fux and hydraulic efort. The Reynolds number in the circular ring is instead of the mass fow rate constant during all optimizations. The result from a thermal perspective is an optimal width of the circular ring of nearly zero. The hydraulically optimal inner pipe radius is 54\% of the outer pipe radius for laminar fow and 60\% for turbulent fow scenarios. Net-exergetic optimization shows a predominant infuence of hydraulic losses, especially for small temperature gains. The exact result depends on the earth's thermal properties and the fow type. Conclusively, coaxial geothermal probes' design should focus on the hydraulic optimum and take the thermal optimum as a secondary criterion due to the dominating hydraulics.},
  language  = {en}
}
@article{PoghossianSchoening2021,
  author    = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Recent progress in silicon-based biologically sensitive field-effect devices},
  series = {Current Opinion in Electrochemistry},
  journal   = {Current Opinion in Electrochemistry},
  number    = {Article number: 100811},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {2451-9103},
  doi       = {10.1016/j.coelec.2021.100811},
  year      = {2021},
  abstract  = {Biologically sensitive field-effect devices (BioFEDs) advantageously combine the electronic field-effect functionality with the (bio)chemical receptor's recognition ability for (bio)chemical sensing. In this review, basic and widely applied device concepts of silicon-based BioFEDs (ion-sensitive field-effect transistor, silicon nanowire transistor, electrolyte-insulator-semiconductor capacitor, light-addressable potentiometric sensor) are presented and recent progress (from 2019 to early 2021) is discussed. One of the main advantages of BioFEDs is the label-free sensing principle enabling to detect a large variety of biomolecules and bioparticles by their intrinsic charge. The review encompasses applications of BioFEDs for the label-free electrical detection of clinically relevant protein biomarkers, deoxyribonucleic acid molecules and viruses, enzyme-substrate reactions as well as recording of the cell acidification rate (as an indicator of cellular metabolism) and the extracellular potential.},
  language  = {en}
}
@article{HugenrothBorchardtRitteretal.2021,
  author    = {Hugenroth, Kristin and Borchardt, Ralf and Ritter, Philine and Groß‑Hardt, Sascha and Meyns, Bart and Verbelen, Tom and Steinseifer, Ulrich and Kaufmann, Tim A. S. and Engelmann, Ulrich M.},
  title     = {Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input},
  series = {Scientific Reports},
  volume    = {11},
  journal   = {Scientific Reports},
  number    = {Art. No. 16800},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-96397-2},
  pages     = {1 -- 12},
  year      = {2021},
  abstract  = {Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5\% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6\%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.},
  language  = {en}
}
@article{NeumaierWeissVeldemanetal.2021,
  author    = {Neumaier, Felix and Weiss, Miriam and Veldeman, Michael and Kotliar, Konstantin and Wiesmann, Martin and Schulze-Steinen, Henna and H{\"o}llig, Anke and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid},
  title     = {Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage - preliminary findings from an observational cohort study},
  series = {Clinical Neurology and Neurosurgery},
  volume    = {208},
  journal   = {Clinical Neurology and Neurosurgery},
  number    = {Article No.: 106870},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0303-8467},
  doi       = {10.1016/j.clineuro.2021.106870},
  year      = {2021},
  abstract  = {Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.},
  language  = {en}
}
@inproceedings{MerkensHebel2021,
  author    = {Merkens, Torsten and Hebel, Christoph},
  title     = {Sharing mobility concepts - flexible, sustainable, smart},
  series = {Proceedings of the 1st UNITED - Southeast Asia Automotive Interest Group (SAIG)},
  booktitle = {Proceedings of the 1st UNITED - Southeast Asia Automotive Interest Group (SAIG)},
  isbn      = {978-3-902103-94-9},
  pages     = {43 -- 44},
  year      = {2021},
  language  = {en}
}
@article{BrockhausBehbahaniMurisetal.2021,
  author    = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz- Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.},
  title     = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept},
  series = {Artificial Organs},
  volume    = {45},
  journal   = {Artificial Organs},
  number    = {12},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1525-1594},
  doi       = {10.1111/aor.14046},
  pages     = {1513 -- 1521},
  year      = {2021},
  abstract  = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.},
  language  = {en}
}
@inproceedings{TranStaat2021,
  author    = {Tran, Ngoc Trinh and Staat, Manfred},
  title     = {FEM shakedown analysis of Kirchhoff-Love plates under uncertainty of strength},
  series = {Proceedings of UNCECOMP 2021},
  booktitle = {Proceedings of UNCECOMP 2021},
  isbn      = {978-618-85072-6-5},
  doi       = {10.7712/120221.8041.19047},
  pages     = {323 -- 338},
  year      = {2021},
  abstract  = {A new formulation to calculate the shakedown limit load of Kirchhoff plates under stochastic conditions of strength is developed. Direct structural reliability design by chance con-strained programming is based on the prescribed failure probabilities, which is an effective approach of stochastic programming if it can be formulated as an equivalent deterministic optimization problem. We restrict uncertainty to strength, the loading is still deterministic. A new formulation is derived in case of random strength with lognormal distribution. Upper bound and lower bound shakedown load factors are calculated simultaneously by a dual algorithm.},
  language  = {en}
}
@phdthesis{Jung2021,
  author    = {Jung, Alexander},
  title     = {Electromechanical modelling and simulation of hiPSC-derived cardiac cell cultures},
  publisher = {Universit{\"a}t Duisburg-Essen},
  isbn      = {978-3-9821811-1-0},
  url       = {http://nbn-resolving.de/https://nbn-resolving.org/urn:nbn:de:hbz:464-20210624-134942-7},
  pages     = {III, 135 Seiten},
  year      = {2021},
  language  = {en}
}
@inproceedings{HoegenDonckerBragardetal.2021,
  author    = {Hoegen, Anne von and Doncker, Rik W. De and Bragard, Michael and Hoegen, Svenja von},
  title     = {Problem-Based Learning in Automation Engineering: Performing a Remote Laboratory Session Serving Various Educational Attainments},
  series = {2021 IEEE Global Engineering Education Conference (EDUCON)},
  booktitle = {2021 IEEE Global Engineering Education Conference (EDUCON)},
  doi       = {10.1109/EDUCON46332.2021.9453925},
  pages     = {1605 -- 1614},
  year      = {2021},
  language  = {en}
}
@inproceedings{HueningStuettgen2021,
  author    = {H{\"u}ning, Felix and St{\"u}ttgen, Marcel},
  title     = {Work in Progress: Interdisciplinary projects in times of COVID-19 crisis - challenges, risks and chances},
  series = {2021 IEEE Global Engineering Education Conference (EDUCON)},
  booktitle = {2021 IEEE Global Engineering Education Conference (EDUCON)},
  doi       = {10.1109/EDUCON46332.2021.9454006},
  pages     = {1175 -- 1179},
  year      = {2021},
  language  = {en}
}
@article{GoettenFingerHavermannetal.2021,
  author    = {G{\"o}tten, Falk and Finger, Felix and Havermann, Marc and Braun, Carsten and Marino, M. and Bil, C.},
  title     = {Full configuration drag estimation of short-to-medium range fixed-wing UAVs and its impact on initial sizing optimization},
  series = {CEAS Aeronautical Journal},
  volume    = {12},
  journal   = {CEAS Aeronautical Journal},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1869-5590 (Online)},
  doi       = {10.1007/s13272-021-00522-w},
  pages     = {589 -- 603},
  year      = {2021},
  abstract  = {The paper presents the derivation of a new equivalent skin friction coefficient for estimating the parasitic drag of short-to-medium range fixed-wing unmanned aircraft. The new coefficient is derived from an aerodynamic analysis of ten different unmanned aircraft used for surveillance, reconnaissance, and search and rescue missions. The aircraft is simulated using a validated unsteady Reynolds-averaged Navier Stokes approach. The UAV's parasitic drag is significantly influenced by the presence of miscellaneous components like fixed landing gears or electro-optical sensor turrets. These components are responsible for almost half of an unmanned aircraft's total parasitic drag. The new equivalent skin friction coefficient accounts for these effects and is significantly higher compared to other aircraft categories. It is used to initially size an unmanned aircraft for a typical reconnaissance mission. The improved parasitic drag estimation yields a much heavier unmanned aircraft when compared to the sizing results using available drag data of manned aircraft.},
  language  = {en}
}
@inproceedings{OlderogMohrBegingetal.2021,
  author    = {Olderog, M. and Mohr, P. and Beging, Stefan and Tsoumpas, C. and Ziemons, Karl},
  title     = {Simulation study on the role of tissue-scattered events in improving sensitivity for a compact time of flight compton positron emission tomograph},
  series = {2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)},
  booktitle = {2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)},
  publisher = {IEEE},
  isbn      = {978-1-7281-7693-2},
  doi       = {10.1109/NSS/MIC42677.2020.9507901},
  pages     = {4 Seiten},
  year      = {2021},
  abstract  = {In positron emission tomography improving time, energy and spatial detector resolutions and using Compton kinematics introduces the possibility to reconstruct a radioactivity distribution image from scatter coincidences, thereby enhancing image quality. The number of single scattered coincidences alone is in the same order of magnitude as true coincidences. In this work, a compact Compton camera module based on monolithic scintillation material is investigated as a detector ring module. The detector interactions are simulated with Monte Carlo package GATE. The scattering angle inside the tissue is derived from the energy of the scattered photon, which results in a set of possible scattering trajectories or broken line of response. The Compton kinematics collimation reduces the number of solutions. Additionally, the time of flight information helps localize the position of the annihilation. One of the questions of this investigation is related to how the energy, spatial and temporal resolutions help confine the possible annihilation volume. A comparison of currently technically feasible detector resolutions (under laboratory conditions) demonstrates the influence on this annihilation volume and shows that energy and coincidence time resolution have a significant impact. An enhancement of the latter from 400 ps to 100 ps leads to a smaller annihilation volume of around 50\%, while a change of the energy resolution in the absorber layer from 12\% to 4.5\% results in a reduction of 60\%. The inclusion of single tissue-scattered data has the potential to increase the sensitivity of a scanner by a factor of 2 to 3 times. The concept can be further optimized and extended for multiple scatter coincidences and subsequently validated by a reconstruction algorithm.},
  language  = {en}
}
@article{HacklBuessKammerlohretal.2021,
  author    = {Hackl, Michael and Buess, Eduard and Kammerlohr, Sandra and Nacov, Julia and Staat, Manfred and Leschinger, Tim and M{\"u}ller, Lars P. and Wegmann, Kilian},
  title     = {A "comma sign"-directed subscapularis repair in anterosuperior rotator cuff tears yields biomechanical advantages in a cadaveric model},
  series = {The american journal of sports medicine},
  volume    = {49},
  journal   = {The american journal of sports medicine},
  number    = {12},
  publisher = {Sage},
  address   = {London},
  issn      = {1552-3365},
  doi       = {10.1177/03635465211031506},
  pages     = {3212 -- 3217},
  year      = {2021},
  abstract  = {Background: Additional stabilization of the "comma sign" in anterosuperior rotator cuff repair has been proposed to provide biomechanical benefits regarding stability of the repair. Purpose: This in vitro investigation aimed to investigate the influence of a comma sign-directed reconstruction technique for anterosuperior rotator cuff tears on the primary stability of the subscapularis tendon repair. Study Design: Controlled laboratory study. Methods: A total of 18 fresh-frozen cadaveric shoulders were used in this study. Anterosuperior rotator cuff tears (complete full-thickness tear of the supraspinatus and subscapularis tendons) were created, and supraspinatus repair was performed with a standard suture bridge technique. The subscapularis was repaired with either a (1) single-row or (2) comma sign technique. A high-resolution 3D camera system was used to analyze 3-mm and 5-mm gap formation at the subscapularis tendon-bone interface upon incremental cyclic loading. Moreover, the ultimate failure load of the repair was recorded. A Mann-Whitney test was used to assess significant differences between the 2 groups. Results: The comma sign repair withstood significantly more loading cycles than the single-row repair until 3-mm and 5-mm gap formation occurred (P≤ .047). The ultimate failure load did not reveal any significant differences when the 2 techniques were compared (P = .596). Conclusion: The results of this study show that additional stabilization of the comma sign enhanced the primary stability of subscapularis tendon repair in anterosuperior rotator cuff tears. Although this stabilization did not seem to influence the ultimate failure load, it effectively decreased the micromotion at the tendon-bone interface during cyclic loading. Clinical Relevance: The proposed technique for stabilization of the comma sign has shown superior biomechanical properties in comparison with a single-row repair and might thus improve tendon healing. Further clinical research will be necessary to determine its influence on the functional outcome.},
  language  = {en}
}
@article{Staat2021,
  author    = {Staat, Manfred},
  title     = {An extension strain type Mohr-Coulomb criterion},
  series = {Rock mechanics and rock engineering},
  volume    = {54},
  journal   = {Rock mechanics and rock engineering},
  number    = {12},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1434-453X},
  doi       = {10.1007/s00603-021-02608-7},
  pages     = {6207 -- 6233},
  year      = {2021},
  abstract  = {Extension fractures are typical for the deformation under low or no confining pressure. They can be explained by a phenomenological extension strain failure criterion. In the past, a simple empirical criterion for fracture initiation in brittle rock has been developed. In this article, it is shown that the simple extension strain criterion makes unrealistic strength predictions in biaxial compression and tension. To overcome this major limitation, a new extension strain criterion is proposed by adding a weighted principal shear component to the simple criterion. The shear weight is chosen, such that the enriched extension strain criterion represents the same failure surface as the Mohr-Coulomb (MC) criterion. Thus, the MC criterion has been derived as an extension strain criterion predicting extension failure modes, which are unexpected in the classical understanding of the failure of cohesive-frictional materials. In progressive damage of rock, the most likely fracture direction is orthogonal to the maximum extension strain leading to dilatancy. The enriched extension strain criterion is proposed as a threshold surface for crack initiation CI and crack damage CD and as a failure surface at peak stress CP. Different from compressive loading, tensile loading requires only a limited number of critical cracks to cause failure. Therefore, for tensile stresses, the failure criteria must be modified somehow, possibly by a cut-off corresponding to the CI stress. Examples show that the enriched extension strain criterion predicts much lower volumes of damaged rock mass compared to the simple extension strain criterion.},
  language  = {en}
}
@article{GriegerSchwabedalWendeletal.2021,
  author    = {Grieger, Niklas and Schwabedal, Justus T. C. and Wendel, Stefanie and Ritze, Yvonne and Bialonski, Stephan},
  title     = {Automated scoring of pre-REM sleep in mice with deep learning},
  series = {Scientific Reports},
  volume    = {11},
  journal   = {Scientific Reports},
  number    = {Art. 12245},
  publisher = {Springer Nature},
  address   = {London},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-021-91286-0},
  year      = {2021},
  abstract  = {Reliable automation of the labor-intensive manual task of scoring animal sleep can facilitate the analysis of long-term sleep studies. In recent years, deep-learning-based systems, which learn optimal features from the data, increased scoring accuracies for the classical sleep stages of Wake, REM, and Non-REM. Meanwhile, it has been recognized that the statistics of transitional stages such as pre-REM, found between Non-REM and REM, may hold additional insight into the physiology of sleep and are now under vivid investigation. We propose a classification system based on a simple neural network architecture that scores the classical stages as well as pre-REM sleep in mice. When restricted to the classical stages, the optimized network showed state-of-the-art classification performance with an out-of-sample F1 score of 0.95 in male C57BL/6J mice. When unrestricted, the network showed lower F1 scores on pre-REM (0.5) compared to the classical stages. The result is comparable to previous attempts to score transitional stages in other species such as transition sleep in rats or N1 sleep in humans. Nevertheless, we observed that the sequence of predictions including pre-REM typically transitioned from Non-REM to REM reflecting sleep dynamics observed by human scorers. Our findings provide further evidence for the difficulty of scoring transitional sleep stages, likely because such stages of sleep are under-represented in typical data sets or show large inter-scorer variability. We further provide our source code and an online platform to run predictions with our trained network.},
  language  = {en}
}
@article{BallVoegeleGrajewskietal.2021,
  author    = {Ball, Christopher Stephen and V{\"o}gele, Stefan and Grajewski, Matthias and Kuckshinrichs, Wilhelm},
  title     = {E-mobility from a multi-actor point of view: Uncertainties and their impacts},
  series = {Technological Forecasting and Social Change},
  volume    = {170},
  journal   = {Technological Forecasting and Social Change},
  number    = {Art. 120925},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0040-1625},
  doi       = {10.1016/j.techfore.2021.120925},
  year      = {2021},
  language  = {en}
}
@incollection{EngelmannShashaSlabu2021,
  author    = {Engelmann, Ulrich M. and Shasha, Carolyn and Slabu, Ioana},
  title     = {Magnetic nanoparticle relaxation in biomedical application: focus on simulating nanoparticle heating},
  series = {Magnetic nanoparticles in human health and medicine},
  booktitle = {Magnetic nanoparticles in human health and medicine},
  publisher = {Wiley-Blackwell},
  address   = {Hoboken, New Jeersey},
  isbn      = {978-1-119-75467-1},
  pages     = {327 -- 354},
  year      = {2021},
  language  = {en}
}
@inproceedings{BornheimGriegerBialonski2021,
  author    = {Bornheim, Tobias and Grieger, Niklas and Bialonski, Stephan},
  title     = {FHAC at GermEval 2021: Identifying German toxic, engaging, and fact-claiming comments with ensemble learning},
  series = {Proceedings of the GermEval 2021 Workshop on the Identification of Toxic, Engaging, and Fact-Claiming Comments : 17th Conference on Natural Language Processing KONVENS 2021},
  booktitle = {Proceedings of the GermEval 2021 Workshop on the Identification of Toxic, Engaging, and Fact-Claiming Comments : 17th Conference on Natural Language Processing KONVENS 2021},
  publisher = {Heinrich Heine University},
  address   = {D{\"u}sseldorf},
  doi       = {10.48415/2021/fhw5-x128},
  pages     = {105 -- 111},
  year      = {2021},
  language  = {en}
}
@article{HagenkampBlankeDoering2021,
  author    = {Hagenkamp, Markus and Blanke, Tobias and D{\"o}ring, Bernd},
  title     = {Thermoelectric building temperature control: a potential assessment},
  series = {International Journal of Energy and Environmental Engineering},
  volume    = {13},
  journal   = {International Journal of Energy and Environmental Engineering},
  publisher = {Springer},
  address   = {Berlin},
  doi       = {10.1007/s40095-021-00424-x},
  pages     = {241 -- 254},
  year      = {2021},
  abstract  = {This study focuses on thermoelectric elements (TEE) as an alternative for room temperature control. TEE are semi-conductor devices that can provide heating and cooling via a heat pump effect without direct noise emissions and no refrigerant use. An efficiency evaluation of the optimal operating mode is carried out for different numbers of TEE, ambient temperatures, and heating loads. The influence of an additional heat recovery unit on system efficiency and an unevenly distributed heating demand are examined. The results show that TEE can provide heat at a coefficient of performance (COP) greater than one especially for small heating demands and high ambient temperatures. The efficiency increases with the number of elements in the system and is subject to economies of scale. The best COP exceeds six at optimal operating conditions. An additional heat recovery unit proves beneficial for low ambient temperatures and systems with few TEE. It makes COPs above one possible at ambient temperatures below 0 ∘C. The effect increases efficiency by maximal 0.81 (from 1.90 to 2.71) at ambient temperature 5 K below room temperature and heating demand Q˙h=100W but is subject to diseconomies of scale. Thermoelectric technology is a valuable option for electricity-based heat supply and can provide cooling and ventilation functions. A careful system design as well as an additional heat recovery unit significantly benefits the performance. This makes TEE superior to direct current heating systems and competitive to heat pumps for small scale applications with focus on avoiding noise and harmful refrigerants.},
  language  = {en}
}
@inproceedings{KernImaniVashianiTimmermanns2021,
  author    = {Kern, Alexander and Imani Vashiani, Anahita and Timmermanns, Tobias},
  title     = {Threat for human beings due to touch voltages and body currents caused by direct lightning strikes in case of non-isolated lightning protection systems using natural components},
  series = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)},
  booktitle = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)},
  publisher = {IEEE},
  isbn      = {978-1-6654-2346-5},
  doi       = {10.1109/ICLPandSIPDA54065.2021.9627465},
  pages     = {8 Seiten},
  year      = {2021},
  abstract  = {For typical cases of non-isolated lightning protection systems (LPS) the impulse currents are investigated which may flow through a human body directly touching a structural part of the LPS. Based on a basic LPS model with conventional down-conductors especially the cases of external and internal steel columns and metal fa{\c{c}}ades are considered and compared. Numerical simulations of the line quantities voltages and currents in the time domain are performed with an equivalent circuit of the entire LPS. As a result it can be stated that by increasing the number of conventional down-conductors and external steel columns the threat for a human being can indeed be reduced, but not down to an acceptable limit. In case of internal steel columns used as natural down-conductors the threat can be reduced sufficiently, depending on the low-resistive connection of the steel columns to the lightning equipotential bonding or the earth termination system, resp. If a metal fa{\c{c}}ade is used the threat for human beings touching is usually very low, if the fa{\c{c}}ade is sufficiently interconnected and multiply connected to the lightning equipotential bonding or the earth termination system, resp.},
  language  = {en}
}
@book{Pieper2021,
  author    = {Pieper, Martin},
  title     = {Quantum mechanics: Introduction to mathematical formulation},
  publisher = {Springer},
  address   = {Wiesbaden},
  isbn      = {978-3-658-32644-9},
  doi       = {10.1007/978-3-658-32645-6},
  pages     = {XIII, 33},
  year      = {2021},
  abstract  = {Anyone who has always wanted to understand the hieroglyphs on Sheldon's blackboard in the TV series The Big Bang Theory or who wanted to know exactly what the fate of Schr{\"o}dinger's cat is all about will find a short, descriptive introduction to the world of quantum mechanics in this essential. The text particularly focuses on the mathematical description in the Hilbert space. The content goes beyond popular scientific presentations, but is nevertheless suitable for readers without special prior knowledge thanks to the clear examples.},
  language  = {en}
}
@inproceedings{EnglhardWeberArent2021,
  author    = {Englhard, Markus and Weber, Tobias and Arent, Jan-Christoph},
  title     = {Efficiency enhancement for CFRP-Prepregautoclave manufacturing by means of simulation-assisted loading optimization},
  series = {Proceedings of SAMPE Europe Conference 2021},
  booktitle = {Proceedings of SAMPE Europe Conference 2021},
  pages     = {8 Seiten},
  year      = {2021},
  abstract  = {A new method for improved autoclave loading within the restrictive framework of helicopter manufacturing is proposed. It is derived from experimental and numerical studies of the curing process and aims at optimizing tooling positions in the autoclave for fast and homogeneous heat-up. The mold positioning is based on two sets of information. The thermal properties of the molds, which can be determined via semi-empirical thermal simulation. The second information is a previously determined distribution of heat transfer coefficients inside the autoclave. Finally, an experimental proof of concept is performed to show a cycle time reduction of up to 31\% using the proposed methodology.},
  language  = {en}
}
@inproceedings{NikolovskiRekeElsenetal.2021,
  author    = {Nikolovski, Gjorgji and Reke, Michael and Elsen, Ingo and Schiffer, Stefan},
  title     = {Machine learning based 3D object detection for navigation in unstructured environments},
  series = {2021 IEEE Intelligent Vehicles Symposium Workshops (IV Workshops)},
  booktitle = {2021 IEEE Intelligent Vehicles Symposium Workshops (IV Workshops)},
  publisher = {IEEE},
  isbn      = {978-1-6654-7921-9},
  doi       = {10.1109/IVWorkshops54471.2021.9669218},
  pages     = {236 -- 242},
  year      = {2021},
  abstract  = {In this paper we investigate the use of deep neural networks for 3D object detection in uncommon, unstructured environments such as in an open-pit mine. While neural nets are frequently used for object detection in regular autonomous driving applications, more unusual driving scenarios aside street traffic pose additional challenges. For one, the collection of appropriate data sets to train the networks is an issue. For another, testing the performance of trained networks often requires tailored integration with the particular domain as well. While there exist different solutions for these problems in regular autonomous driving, there are only very few approaches that work for special domains just as well. We address both the challenges above in this work. First, we discuss two possible ways of acquiring data for training and evaluation. That is, we evaluate a semi-automated annotation of recorded LIDAR data and we examine synthetic data generation. Using these datasets we train and test different deep neural network for the task of object detection. Second, we propose a possible integration of a ROS2 detector module for an autonomous driving platform. Finally, we present the performance of three state-of-the-art deep neural networks in the domain of 3D object detection on a synthetic dataset and a smaller one containing a characteristic object from an open-pit mine.},
  language  = {en}
}
@article{EngemannCoenenDawaretal.2021,
  author    = {Engemann, Heiko and C{\"o}nen, Patrick and Dawar, Harshal and Du, Shengzhi and Kallweit, Stephan},
  title     = {A robot-assisted large-scale inspection of wind turbine blades in manufacturing using an autonomous mobile manipulator},
  series = {Applied Sciences},
  volume    = {11},
  journal   = {Applied Sciences},
  number    = {19},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2076-3417},
  doi       = {10.3390/app11199271},
  pages     = {1 -- 22},
  year      = {2021},
  abstract  = {Wind energy represents the dominant share of renewable energies. The rotor blades of a wind turbine are typically made from composite material, which withstands high forces during rotation. The huge dimensions of the rotor blades complicate the inspection processes in manufacturing. The automation of inspection processes has a great potential to increase the overall productivity and to create a consistent reliable database for each individual rotor blade. The focus of this paper is set on the process of rotor blade inspection automation by utilizing an autonomous mobile manipulator. The main innovations include a novel path planning strategy for zone-based navigation, which enables an intuitive right-hand or left-hand driving behavior in a shared human-robot workspace. In addition, we introduce a new method for surface orthogonal motion planning in connection with large-scale structures. An overall execution strategy controls the navigation and manipulation processes of the long-running inspection task. The implemented concepts are evaluated in simulation and applied in a real-use case including the tip of a rotor blade form.},
  language  = {en}
}
@incollection{AltherrLeise2021,
  author    = {Altherr, Lena and Leise, Philipp},
  title     = {Resilience as a concept for mastering uncertainty},
  series = {Mastering Uncertainty in Mechanical Engineering},
  booktitle = {Mastering Uncertainty in Mechanical Engineering},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-78353-2},
  doi       = {10.1007/978-3-030-78354-9},
  pages     = {412 -- 417},
  year      = {2021},
  language  = {en}
}
@incollection{AltherrLeisePfetschetal.2021,
  author    = {Altherr, Lena and Leise, Philipp and Pfetsch, Marc E. and Schmitt, Andreas},
  title     = {Optimal design of resilient technical systems on the example of water supply systems},
  series = {Mastering Uncertainty in Mechanical Engineering},
  booktitle = {Mastering Uncertainty in Mechanical Engineering},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-78356-3},
  pages     = {429 -- 433},
  year      = {2021},
  language  = {en}
}
@incollection{LeiseAltherr2021,
  author    = {Leise, Philipp and Altherr, Lena},
  title     = {Experimental evaluation of resilience metrics in a fluid system},
  series = {Mastering Uncertainty in Mechanical Engineering},
  booktitle = {Mastering Uncertainty in Mechanical Engineering},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-78356-3},
  pages     = {442 -- 447},
  year      = {2021},
  language  = {en}
}
@article{MonakhovaDiehl2021,
  author    = {Monakhova, Yulia and Diehl, Bernd W.K.},
  title     = {Novel approach of qNMR workflow by standardization using 2H integral: Application to any intrinsic calibration standard},
  series = {Talanta},
  volume    = {222},
  journal   = {Talanta},
  number    = {Article number: 121504},
  publisher = {Elsevier},
  isbn      = {0039-9140},
  doi       = {10.1016/j.talanta.2020.121504},
  year      = {2021},
  abstract  = {Quantitative nuclear magnetic resonance (qNMR) is routinely performed by the internal or external standardization. The manuscript describes a simple alternative to these common workflows by using NMR signal of another active nuclei of calibration compound. For example, for any arbitrary compound quantification by NMR can be based on the use of an indirect concentration referencing that relies on a solvent having both 1H and 2H signals. To perform high-quality quantification, the deuteration level of the utilized deuterated solvent has to be estimated. In this contribution the new method was applied to the determination of deuteration levels in different deuterated solvents (MeOD, ACN, CDCl3, acetone, benzene, DMSO-d6). Isopropanol-d6, which contains a defined number of deuterons and protons, was used for standardization. Validation characteristics (precision, accuracy, robustness) were calculated and the results showed that the method can be used in routine practice. Uncertainty budget was also evaluated. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and can be applied in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).},
  language  = {en}
}
@article{BurmistrovaSobolevaMonakhova2021,
  author    = {Burmistrova, Natalia A. and Soboleva, Polina M. and Monakhova, Yulia},
  title     = {Is infrared spectroscopy combined with multivariate analysis a promising tool for heparin authentication?},
  series = {Journal of Pharmaceutical and Biomedical Analysis},
  volume    = {194},
  journal   = {Journal of Pharmaceutical and Biomedical Analysis},
  number    = {Article number: 113811},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0731-7085},
  doi       = {10.1016/j.jpba.2020.113811},
  year      = {2021},
  abstract  = {The investigation of the possibility to determine various characteristics of powder heparin (n = 115) was carried out with infrared spectroscopy. The evaluation of heparin samples included several parameters such as purity grade, distributing company, animal source as well as heparin species (i.e. Na-heparin, Ca-heparin, and heparinoids). Multivariate analysis using principal component analysis (PCA), soft independent modelling of class analogy (SIMCA), and partial least squares - discriminant analysis (PLS-DA) were applied for the modelling of spectral data. Different pre-processing methods were applied to IR spectral data; multiplicative scatter correction (MSC) was chosen as the most relevant. Obtained results were confirmed by nuclear magnetic resonance (NMR) spectroscopy. Good predictive ability of this approach demonstrates the potential of IR spectroscopy and chemometrics for screening of heparin quality. This approach, however, is designed as a screening tool and is not considered as a replacement for either of the methods required by USP and FDA.},
  language  = {en}
}
@article{MonakhovaDiehl2021,
  author    = {Monakhova, Yulia and Diehl, Bernd W. K.},
  title     = {Simplification of NMR Workflows by Standardization Using 2H Integral of Deuterated Solvent as Applied to Aloe vera Preparations},
  series = {Applied Magnetic Resonance},
  volume    = {52},
  journal   = {Applied Magnetic Resonance},
  number    = {11},
  publisher = {Springer},
  address   = {Cham},
  issn      = {1613-7507},
  doi       = {10.1007/s00723-021-01393-4},
  pages     = {1591 -- 1600},
  year      = {2021},
  abstract  = {In this study, a recently proposed NMR standardization approach by 2H integral of deuterated solvent for quantitative multicomponent analysis of complex mixtures is presented. As a proof of principle, the existing NMR routine for the analysis of Aloe vera products was modified. Instead of using absolute integrals of targeted compounds and internal standard (nicotinamide) from 1H-NMR spectra, quantification was performed based on the ratio of a particular 1H-NMR compound integral and 2H-NMR signal of deuterated solvent D2O. Validation characteristics (linearity, repeatability, accuracy) were evaluated and the results showed that the method has the same precision as internal standardization in case of multicomponent screening. Moreover, a dehydration process by freeze drying is not necessary for the new routine. Now, our NMR profiling of A. vera products needs only limited sample preparation and data processing. The new standardization methodology provides an appealing alternative for multicomponent NMR screening. In general, this novel approach, using standardization by 2H integral, benefits from reduced sample preparation steps and uncertainties, and is recommended in different application areas (purity determination, forensics, pharmaceutical analysis, etc.).},
  language  = {en}
}
@article{BurgerRumpfDoetal.2021,
  author    = {Burger, Ren{\´e} and Rumpf, Jessica and Do, Xuan Tung and Monakhova, Yulia and Diehl, Bernd W. K. and Rehahn, Matthias and Schulze, Margit},
  title     = {Is NMR combined with multivariate regression applicable for the molecular weight determination of randomly cross-linked polymers such as lignin?},
  series = {ACS Omega},
  volume    = {6},
  journal   = {ACS Omega},
  number    = {44},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {2470-1343},
  doi       = {10.1021/acsomega.1c03574},
  pages     = {29516 -- 29524},
  year      = {2021},
  abstract  = {The molecular weight properties of lignins are one of the key elements that need to be analyzed for a successful industrial application of these promising biopolymers. In this study, the use of 1H NMR as well as diffusion-ordered spectroscopy (DOSY NMR), combined with multivariate regression methods, was investigated for the determination of the molecular weight (Mw and Mn) and the polydispersity of organosolv lignins (n = 53, Miscanthus x giganteus, Paulownia tomentosa, and Silphium perfoliatum). The suitability of the models was demonstrated by cross validation (CV) as well as by an independent validation set of samples from different biomass origins (beech wood and wheat straw). CV errors of ca. 7-9 and 14-16\% were achieved for all parameters with the models from the 1H NMR spectra and the DOSY NMR data, respectively. The prediction errors for the validation samples were in a similar range for the partial least squares model from the 1H NMR data and for a multiple linear regression using the DOSY NMR data. The results indicate the usefulness of NMR measurements combined with multivariate regression methods as a potential alternative to more time-consuming methods such as gel permeation chromatography.},
  language  = {en}
}
@incollection{CzarneckiHongSchmitzetal.2021,
  author    = {Czarnecki, Christian and Hong, Chin-Gi and Schmitz, Manfred and Dietze, Christian},
  title     = {Enabling digital transformation through cognitive robotic process automation at Deutsche Telekom Services Europe},
  series = {Digitalization Cases Vol. 2 : Mastering digital transformation for global business},
  booktitle = {Digitalization Cases Vol. 2 : Mastering digital transformation for global business},
  editor    = {Urbach, Nils and R{\"o}glinger, Maximilian and Kautz, Karlheinz and Alias, Rose Alinda and Saunders, Carol and Wiener, Martin},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-80002-4 (Print)},
  doi       = {10.1007/978-3-030-80003-1},
  pages     = {123 -- 138},
  year      = {2021},
  abstract  = {Subject of this case is Deutsche Telekom Services Europe (DTSE), a service center for administrative processes. Due to the high volume of repetitive tasks (e.g., 100k manual uploads of offer documents into SAP per year), automation was identified as an important strategic target with a high management attention and commitment. DTSE has to work with various backend application systems without any possibility to change those systems. Furthermore, the complexity of administrative processes differed. When it comes to the transfer of unstructured data (e.g., offer documents) to structured data (e.g., MS Excel files), further cognitive technologies were needed.},
  language  = {en}
}
@incollection{CzarneckiFettke2021,
  author    = {Czarnecki, Christian and Fettke, Peter},
  title     = {Robotic process automation : Positioning, structuring, and framing the work},
  series = {Robotic process automation : Management, technology, applications},
  booktitle = {Robotic process automation : Management, technology, applications},
  editor    = {Czarnecki, Christian and Fettke, Peter},
  publisher = {De Gruyter},
  address   = {Oldenbourg},
  isbn      = {978-3-11-067668-6 (Print)},
  doi       = {10.1515/9783110676693-202},
  pages     = {3 -- 24},
  year      = {2021},
  abstract  = {Robotic process automation (RPA) has attracted increasing attention in research and practice. This chapter positions, structures, and frames the topic as an introduction to this book. RPA is understood as a broad concept that comprises a variety of concrete solutions. From a management perspective RPA offers an innovative approach for realizing automation potentials, whereas from a technical perspective the implementation based on software products and the impact of artificial intelligence (AI) and machine learning (ML) are relevant. RPA is industry-independent and can be used, for example, in finance, telecommunications, and the public sector. With respect to RPA this chapter discusses definitions, related approaches, a structuring framework, a research framework, and an inside as well as outside architectural view. Furthermore, it provides an overview of the book combined with short summaries of each chapter.},
  language  = {en}
}
@incollection{BensbergAuthCzarnecki2021,
  author    = {Bensberg, Frank and Auth, Gunnar and Czarnecki, Christian},
  title     = {Finding the perfect RPA match : a criteria-based selection method for RPA solutions},
  series = {Robotic process automation : Management, technology, applications},
  booktitle = {Robotic process automation : Management, technology, applications},
  editor    = {Czarnecki, Christian and Fettke, Peter},
  publisher = {De Gruyter},
  address   = {Oldenbourg},
  isbn      = {978-3-11-067677-8},
  doi       = {10.1515/9783110676693-201},
  pages     = {47 -- 75},
  year      = {2021},
  abstract  = {The benefits of robotic process automation (RPA) are highly related to the usage of commercial off-the-shelf (COTS) software products that can be easily implemented and customized by business units. But, how to find the best fitting RPA product for a specific situation that creates the expected benefits? This question is related to the general area of software evaluation and selection. In the face of more than 75 RPA products currently on the market, guidance considering those specifics is required. Therefore, this chapter proposes a criteria-based selection method specifically for RPA. The method includes a quantitative evaluation of costs and benefits as well as a qualitative utility analysis based on functional criteria. By using the visualization of financial implications (VOFI) method, an application-oriented structure is provided that opposes the total cost of ownership to the time savings times salary (TSTS). For the utility analysis a detailed list of functional criteria for RPA is offered. The whole method is based on a multi-vocal review of scientific and non-scholarly literature including publications by business practitioners, consultants, and vendors. The application of the method is illustrated by a concrete RPA example. The illustrated structures, templates, and criteria can be directly utilized by practitioners in their real-life RPA implementations. In addition, a normative decision process for selecting RPA alternatives is proposed before the chapter closes with a discussion and outlook.},
  language  = {en}
}
@incollection{CroonCzarnecki2021,
  author    = {Croon, Philipp and Czarnecki, Christian},
  title     = {Liability for loss or damages caused by RPA},
  series = {Robotic process automation : Management, technology, applications},
  booktitle = {Robotic process automation : Management, technology, applications},
  editor    = {Czarnecki, Christian and Fettke, Peter},
  publisher = {De Gruyter},
  address   = {Oldenbourg},
  isbn      = {9783110676778},
  doi       = {10.1515/9783110676693-202},
  pages     = {135 -- 151},
  year      = {2021},
  abstract  = {Intelligent autonomous software robots replacing human activities and performing administrative processes are reality in today's corporate world. This includes, for example, decisions about invoice payments, identification of customers for a marketing campaign, and answering customer complaints. What happens if such a software robot causes a damage? Due to the complete absence of human activities, the question is not trivial. It could even happen that no one is liable for a damage towards a third party, which could create an uncalculatable legal risk for business partners. Furthermore, the implementation and operation of those software robots involves various stakeholders, which result in the unsolvable endeavor of identifying the originator of a damage. Overall it is advisable to all involved parties to carefully consider the legal situation. This chapter discusses the liability of software robots from an interdisciplinary perspective. Based on different technical scenarios the legal aspects of liability are discussed.},
  language  = {en}
}
@inproceedings{RitschelStenzelCzarneckietal.2021,
  author    = {Ritschel, Konstantin and Stenzel, Adina and Czarnecki, Christian and Hong, Chin-Gi},
  title     = {Realizing robotic process automation potentials: an architectural perspective on a real-life implementation case},
  series = {GI Edition Proceedings Band 314 "INFORMATIK 2021" Computer Science \& Sustainability},
  booktitle = {GI Edition Proceedings Band 314 "INFORMATIK 2021" Computer Science \& Sustainability},
  editor    = {Gesellschaft f{\"u}r Informatik e.V. (GI),},
  publisher = {K{\"o}llen},
  address   = {Bonn},
  isbn      = {9783885797081},
  issn      = {1617-5468},
  pages     = {1303 -- 1311},
  year      = {2021},
  abstract  = {The initial idea of Robotic Process Automation (RPA) is the automation of business processes through a simple emulation of user input and output by software robots. Hence, it can be assumed that no changes of the used software systems and existing Enterprise Architecture (EA) is required. In this short, practical paper we discuss this assumption based on a real-life implementation project. We show that a successful RPA implementation might require architectural work during analysis, implementation, and migration. As practical paper we focus on exemplary lessons-learned and new questions related to RPA and EA.},
  language  = {en}
}
@article{AkimbekovDigelAbdievaetal.2021,
  author    = {Akimbekov, Nuraly and Digel, Ilya and Abdieva, Gulzhamal and Ualieva, Perizat and Tastambek, Kuanysh},
  title     = {Lignite biosolubilization and bioconversion by Bacillus sp.: the collation of analytical data},
  series = {Biofuels},
  volume    = {12},
  journal   = {Biofuels},
  number    = {3},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1759-7277},
  pages     = {247 -- 258},
  year      = {2021},
  abstract  = {The vast metabolic potential of microbes in brown coal (lignite) processing and utilization can greatly contribute to innovative approaches to sustainable production of high-value products from coal. In this study, the multi-faceted and complex coal biosolubilization process by Bacillus sp. RKB 7 isolate from the Kazakhstan coal-mining soil is reported, and the derived products are characterized. Lignite solubilization tests performed for surface and suspension cultures testify to the formation of numerous soluble lignite-derived substances. Almost 24\% of crude lignite (5\% w/v) was solubilized within 14 days under slightly alkaline conditions (pH 8.2). FTIR analysis revealed various functional groups in the obtained biosolubilization products. Analyses of the lignite-derived humic products by UV-Vis and fluorescence spectrometry as well as elemental analysis yielded compatible results indicating the emerging products had a lower molecular weight and degree of aromaticity. Furthermore, XRD and SEM analyses were used to evaluate the biosolubilization processes from mineralogical and microscopic points of view. The findings not only contribute to a deeper understanding of microbe-mineral interactions in coal environments, but also contribute to knowledge of coal biosolubilization and bioconversion with regard to sustainable production of humic substances. The detailed and comprehensive analyses demonstrate the huge biotechnological potential of Bacillus sp. for agricultural productivity and environmental health.},
  language  = {en}
}
@article{KoehlerRoepkeWolf2021,
  author    = {K{\"o}hler, Klemens and R{\"o}pke, Ren{\´e} and Wolf, Martin},
  title     = {Through a mirror darkly - On the obscurity of teaching goals in game-based learning in IT security},
  series = {ISAGA 2019: Simulation Gaming Through Times and Disciplines},
  journal   = {ISAGA 2019: Simulation Gaming Through Times and Disciplines},
  publisher = {Springer},
  address   = {Cham},
  doi       = {10.1007/978-3-030-72132-9_6},
  pages     = {61 -- 73},
  year      = {2021},
  abstract  = {Teachers and instructors use very specific language communicating teaching goals. The most widely used frameworks of common reference are the Bloom's Taxonomy and the Revised Bloom's Taxonomy. The latter provides distinction of 209 different teaching goals which are connected to methods. In Competence Developing Games (CDGs - serious games to convey knowledge) and in IT security education, a two- or three level typology exists, reducing possible learning outcomes to awareness, training, and education. This study explores whether this much simpler framework succeeds in achieving the same range of learning outcomes. Method wise a keyword analysis was conducted. The results were threefold: 1. The words used to describe teaching goals in CDGs on IT security education do not reflect the whole range of learning outcomes. 2. The word choice is nevertheless different from common language, indicating an intentional use of language. 3. IT security CDGs use different sets of terms to describe learning outcomes, depending on whether they are awareness, training, or education games. The interpretation of the findings is that the reduction to just three types of CDGs reduces the capacity to communicate and think about learning outcomes and consequently reduces the outcomes that are intentionally achieved.},
  language  = {en}
}
@article{JildehWagnerSchoening2021,
  author    = {Jildeh, Zaid B. and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef},
  title     = {Sterilization of Objects, Products, and Packaging Surfaces and Their Characterization in Different Fields of Industry: The Status in 2020},
  series = {physica status solidi (a) applications and materials science},
  volume    = {218},
  journal   = {physica status solidi (a) applications and materials science},
  number    = {13},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.202000732},
  pages     = {27 Seiten},
  year      = {2021},
  abstract  = {The treatment method to deactivate viable microorganisms from objects or products is termed sterilization. There are multiple forms of sterilization, each intended to be applied for a specific target, which depends on—but not limited to—the thermal, physical, and chemical stability of that target. Herein, an overview on the currently used sterilization processes in the global market is provided. Different sterilization techniques are grouped under a category that describes the method of treatment: radiation (gamma, electron beam, X-ray, and ultraviolet), thermal (dry and moist heat), and chemical (ethylene oxide, ozone, chlorine dioxide, and hydrogen peroxide). For each sterilization process, the typical process parameters as defined by regulations and the mode of antimicrobial activity are summarized. Finally, the recommended microorganisms that are used as biological indicators to validate sterilization processes in accordance with the rules that are established by various regulatory agencies are summarized.},
  language  = {en}
}
@phdthesis{Bayer2021,
  author    = {Bayer, Robin},
  title     = {Development of a novel in-vitro vascular model for determination of physiological and pathophysiological mechanobiology},
  publisher = {Universit{\"a}t zu K{\"o}ln},
  address   = {K{\"o}ln},
  url       = {http://nbn-resolving.de/urn:nbn:de:hbz:38-362212},
  pages     = {IV, 115 Seiten},
  year      = {2021},
  language  = {en}
}