@article{Wilke2017, author = {Wilke, Thomas}, title = {Newly found plans for the chapel of the Holy Shroud}, series = {Studi Piemontesi}, volume = {XLVI}, journal = {Studi Piemontesi}, number = {1}, issn = {0392-7261}, pages = {75 -- 85}, year = {2017}, language = {en} } @article{WilsonWilsonScheeretal.2017, author = {Wilson, Ian D. and Wilson, Claire E. and Scheer, Nico and Dickie, A.P. and Schreiter, K. and Wilson, E. M. and Riley, R. J. and Wehr, R. and Bial, J.}, title = {The Pharmacokinetics and Metabolism of Lumiracoxib in Chimeric Humanized and Murinized FRG Mice}, series = {Biochemical pharmacology}, volume = {Volume 135}, journal = {Biochemical pharmacology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-2968}, doi = {10.1016/j.bcp.2017.03.015}, pages = {139 -- 150}, year = {2017}, language = {en} } @misc{ArtmannLinderBayeretal.2017, author = {Artmann, Gerhard and Linder, Peter and Bayer, Robin and Gossmann, Matthias}, title = {Celldrum electrode arrangement for measuring mechanical stress [Patent of invention]}, publisher = {WIPO}, address = {Geneva}, pages = {18 Seiten}, year = {2017}, abstract = {The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.}, language = {en} } @incollection{SamuelssonScheerWilsonetal.2017, author = {Samuelsson, K. and Scheer, Nico and Wilson, I. and Wolf, C.R. and Henderson, C.J.}, title = {Genetically Humanized Animal Models}, series = {Comprehensive Medicinal Chemistry III. 3rd Edition}, booktitle = {Comprehensive Medicinal Chemistry III. 3rd Edition}, editor = {Chackalamannil, Samuel}, publisher = {Elsevier}, address = {Saint Louis}, isbn = {978-0-12-803201-5}, doi = {10.1016/B978-0-12-409547-2.12376-5}, pages = {130 -- 149}, year = {2017}, abstract = {Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug-drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.}, language = {en} } @article{EngelmannBuhlBaumannetal.2017, author = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Baumann, Martin and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Agglomeration of magnetic nanoparticles and its effects on magnetic hyperthermia}, series = {Current Directions in Biomedical Engineering}, volume = {3}, journal = {Current Directions in Biomedical Engineering}, number = {2}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2017-0096}, pages = {457 -- 460}, year = {2017}, language = {en} } @article{ChenJostVolkeretal.2017, author = {Chen, Chao and Jost, Peter and Volker, Hanno and Kaminski, Marvin and Wirtssohn, Matti R. and Engelmann, Ulrich M. and Kr{\"u}ger, K. and Schlich, Franziska F. and Schlockermann, Carl and Lobo, Ricardo P.S.M. and Wuttig, Matthias}, title = {Dielectric properties of amorphous phase-change materials}, series = {Physical Review B}, volume = {95}, journal = {Physical Review B}, number = {9}, issn = {2469-9950}, doi = {10.1103/PhysRevB.95.094111}, pages = {Article number 094111}, year = {2017}, language = {en} } @inproceedings{SchreiberKraftZuendorf2017, author = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert}, title = {Metrics Driven Research Collaboration: Focusing on Common Project Goals Continuously}, series = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina}, booktitle = {39th International Conference on Software Engineering, May 20-28, 2017 - Buenos Aires, Argentina}, pages = {8 Seiten}, year = {2017}, abstract = {Research collaborations provide opportunities for both practitioners and researchers: practitioners need solutions for difficult business challenges and researchers are looking for hard problems to solve and publish. Nevertheless, research collaborations carry the risk that practitioners focus on quick solutions too much and that researchers tackle theoretical problems, resulting in products which do not fulfill the project requirements. In this paper we introduce an approach extending the ideas of agile and lean software development. It helps practitioners and researchers keep track of their common research collaboration goal: a scientifically enriched software product which fulfills the needs of the practitioner's business model. This approach gives first-class status to application-oriented metrics that measure progress and success of a research collaboration continuously. Those metrics are derived from the collaboration requirements and help to focus on a commonly defined goal. An appropriate tool set evaluates and visualizes those metrics with minimal effort, and all participants will be pushed to focus on their tasks with appropriate effort. Thus project status, challenges and progress are transparent to all research collaboration members at any time.}, language = {en} } @article{GamellaZakharchenkoGuzetal.2017, author = {Gamella, Maria and Zakharchenko, Andrey and Guz, Nataliia and Masi, Madeline and Minko, Sergiy and Kolpashchikov, Dmitry M. and Iken, Heiko and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {DNA computing system activated by electrochemically triggered DNA realease from a polymer-brush-modified electrode array}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {2}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201600389}, pages = {398 -- 408}, year = {2017}, abstract = {An array of four independently wired indium tin oxide (ITO) electrodes was used for electrochemically stimulated DNA release and activation of DNA-based Identity, AND and XOR logic gates. Single-stranded DNA molecules were loaded on the mixed poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA)/poly(methacrylic acid) (PMAA) brush covalently attached to the ITO electrodes. The DNA deposition was performed at pH 5.0 when the polymer brush is positively charged due to protonation of tertiary amino groups in PDMAEMA, thus resulting in electrostatic attraction of the negatively charged DNA. By applying electrolysis at -1.0 V(vs. Ag/AgCl reference) electrochemical oxygen reduction resulted in the consumption of hydrogen ions and local pH increase near the electrode surface. The process resulted in recharging the polymer brush to the negative state due to dissociation of carboxylic groups of PMAA, thus repulsing the negatively charged DNA and releasing it from the electrode surface. The DNA release was performed in various combinations from different electrodes in the array assembly. The released DNA operated as input signals for activation of the Boolean logic gates. The developed system represents a step forward in DNA computing, combining for the first time DNA chemical processes with electronic input signals.}, language = {en} } @article{SousaSiqueiraVerciketal.2017, author = {Sousa, Marcos A. M. and Siqueira, Jose R. Jr. and Vercik, Andres and Sch{\"o}ning, Michael Josef and Oliveira, Osvaldo N. Jr.}, title = {Determining the optimized layer-by-layer film architecture with dendrimer/carbon nanotubes for field-effect sensors}, series = {IEEE Sensors Journal}, volume = {17}, journal = {IEEE Sensors Journal}, number = {6}, publisher = {IEEE}, address = {New York}, issn = {1558-1748}, doi = {10.1109/JSEN.2017.2653238}, pages = {1735 -- 1740}, year = {2017}, abstract = {The capacitive electrolyte-insulator-semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte-insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors.}, language = {en} } @article{YoshinobuMiyamotoWerneretal.2017, author = {Yoshinobu, Tatsuo and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species}, series = {Annual Review of Analytical Chemistry}, volume = {10}, journal = {Annual Review of Analytical Chemistry}, publisher = {Annual Reviews}, address = {Palo Alto, Calif.}, issn = {1936-1327}, doi = {10.1146/annurev-anchem-061516-045158}, pages = {225 -- 246}, year = {2017}, abstract = {A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.}, language = {en} } @incollection{DuongNguyenStaat2017, author = {Duong, Minh Tuan and Nguyen, Nhu Huynh and Staat, Manfred}, title = {Physical response of hyperelastic models for composite materials and soft tissues}, series = {Advances in Composite Material}, booktitle = {Advances in Composite Material}, publisher = {Scientific Research Publishing}, address = {Wuhan}, isbn = {978-1-61896-300-0 (Hardcover), 978-1-61896-299-7 (Paperback)}, pages = {316}, year = {2017}, language = {en} } @inproceedings{SchreiberKraftZuendorf2017, author = {Schreiber, Marc and Kraft, Bodo and Z{\"u}ndorf, Albert}, title = {Metrics driven research collaboration: focusing on common project goals continuously}, series = {Proceedings : 2017 IEEE/ACM 4th International Workshop on Software Engineering Research and Industrial Practice : SER\&IP 2017 : 21 May 2017 Buenos Aires, Argentina}, booktitle = {Proceedings : 2017 IEEE/ACM 4th International Workshop on Software Engineering Research and Industrial Practice : SER\&IP 2017 : 21 May 2017 Buenos Aires, Argentina}, editor = {Bilof, Randall}, publisher = {IEEE Press}, address = {Piscataway, NJ}, isbn = {978-1-5386-2797-6}, doi = {10.1109/SER-IP.2017..6}, pages = {41 -- 47}, year = {2017}, language = {en} } @inproceedings{SchwankeHoefkenSchuba2017, author = {Schwanke, Peter and H{\"o}fken, Hans-Wilhelm and Schuba, Marko}, title = {Security Analysis of the ADS Protocol of a Beckhoff CX2020 PLC}, pages = {1 -- 5}, year = {2017}, abstract = {ICSs (Industrial Control Systems) and its subset SCADA systems (Supervisory Control and Data Acquisition) are getting exposed to a constant stream of new threats. The increasing importance of IT security in ICS requires viable methods to assess the security of ICS, its individual components, and its protocols. This paper presents a security analysis with focus on the communication protocols of a single PLC (Programmable Logic Controller). The PLC, a Beckhoff CX2020, is examined and new vulnerabilities of the system are revealed. Based on these findings recommendations are made to improve security of the Beckhoff system and its protocols.}, language = {en} } @inproceedings{GranatHoefkenSchuba2017, author = {Granat, Andreas and H{\"o}fken, Hans-Wilhelm and Schuba, Marko}, title = {Intrusion Detection of the ICS Protocol EtherCAT}, pages = {1 -- 5}, year = {2017}, abstract = {Control mechanisms like Industrial Controls Systems (ICS) and its subgroup SCADA (Supervisory Control and Data Acquisition) are a prerequisite to automate industrial processes. While protection of ICS on process management level is relatively straightforward - well known office IT security mechanisms can be used - protection on field bus level is harder to achieve as there are real-time and production requirements like 24x7 to consider. One option to improve security on field bus level is to introduce controls that help to detect and to react on attacks. This paper introduces an initial set of intrusion detection mechanisms for the field bus protocol EtherCAT. To this end existing Ethernet attack vectors including packet injection and man-in-the-middle attacks are tested in an EtherCAT environment, where they could interrupt the EtherCAT network and may even cause physical damage. Based on the signatures of such attacks, a preprocessor and new rule options are defined for the open source intrusion detection system Snort demonstrating the general feasibility of intrusion detection on field bus level.}, language = {en} } @misc{NobisrathZuendorfGeorgeetal.2017, author = {Nobisrath, Ulrich and Z{\"u}ndorf, Albert and George, Tobias and Ruben, Jubeh and Kraft, Bodo}, title = {Software Stories Guide}, pages = {21}, year = {2017}, abstract = {Software Stories are a simple graphical notation for requirements analysis and design in agile software projects. Software Stories are based on example scenarios. Example scenarios facilitate the communication between lay people or domain experts and software experts.}, language = {en} } @article{ArreolaOberlaenderMaetzkowetal.2017, author = {Arreola, Julio and Oberl{\"a}nder, Jan and M{\"a}tzkow, M. and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Surface functionalization for spore-based biosensors with organosilanes}, series = {Electrochimica Acta}, volume = {241}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2017.04.157}, pages = {237 -- 243}, year = {2017}, abstract = {In the present work, surface functionalization of different sensor materials was studied. Organosilanes are well known to serve as coupling agent for biomolecules or cells on inorganic materials. 3-aminopropyltriethoxysilane (APTES) was used to attach microbiological spores time to an interdigitated sensor surface. The functionality and physical properties of APTES were studied on isolated sensor materials, namely silicon dioxide (SiO2) and platinum (Pt) as well as the combined material on sensor level. A predominant immobilization of spores could be demonstrated on SiO2 surfaces. Additionally, the impedance signal of APTES-functionalized biosensor chips has been investigated.}, language = {en} } @inproceedings{AbelPerezVianaCiritsisetal.2017, author = {Abel, Alexander and P{\´e}rez-Viana, Daniel and Ciritsis, Bernard and Staat, Manfred}, title = {Prevention of femur neck fractures through femoroplasty}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {114 -- 115}, year = {2017}, language = {en} } @inproceedings{SuryoputriGhaderiLinderetal.2017, author = {Suryoputri, Nathania and Ghaderi, Aydin and Linder, Peter and Kotliar, Konstantin and G{\"o}ttler, Jens and Sorg, Christian and Grimmer, Timo}, title = {Does hemodynamic response function change in Alzheimer disease?}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {92}, year = {2017}, language = {en} } @inproceedings{SchneiderAlHakimKayseretal.2017, author = {Schneider, Oliver and Al Hakim, Taher and Kayser, Peter and Digel, Ilya}, title = {Development and trials of a test chamber for ultrasound-assisted sampling of living cells from solid surfaces}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {96 -- 97}, year = {2017}, language = {en} } @inproceedings{KuhlenDigel2017, author = {Kuhlen, Max and Digel, Ilya}, title = {Fluorescence signatures and detection limits of ubiquitous terrestrial bio-compounds}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Erni, Daniel and Fischerauer, Alice and Himmel, J{\"o}rg and Seeger, Thomas and Thelen, Klaus}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {102 -- 103}, year = {2017}, language = {en} } @incollection{BarnatBosseTight2017, author = {Barnat, Miriam and Bosse, Elke and Tight, Malcolm}, title = {The Guiding Role of Theory in Mixed-Methods Research: Combining Individual and Institutional Perspectives on the Transition to Higher Education}, series = {Theory and Method in Higher Education Research. Vol 3}, booktitle = {Theory and Method in Higher Education Research. Vol 3}, publisher = {Emerald Publishing Limited}, isbn = {978-1-78743-222-2}, doi = {10.1108/S2056-375220170000003001}, pages = {1 -- 19}, year = {2017}, abstract = {The methodological discourse of mixed-methods research offers general procedures to combine quantitative and qualitative methods for investigating complex fields of research such as higher education. However, integrating different methods still poses considerable challenges. To move beyond general recommendations for mixed-methods research, this chapter proposes to discuss methodological issues with respect to a particular research domain. Taking current studies on the transition to higher education as an example, the authors first provide an overview of the potentials and limitations of quantitative and qualitative methods in the research domain. Second, they show the need for a conceptual framework grounded in the theory of the research object to guide the integration of different methods and findings. Finally, an example study that investigates transition with regard to the interplay of the individual student and the institutional context serves to illustrate the guiding role of theory. The framework integrates different theoretical perspectives on transition, informs the selection of the research methods, and defines the nexus of the two strands that constitute the mixed-methods design. As the interplay of individual and context is of concern for teaching and learning in general, the example presented may be fruitful for the wider field of higher education research.}, language = {en} } @inproceedings{SchmidtsBoltesKraftetal.2017, author = {Schmidts, Oliver and Boltes, Maik and Kraft, Bodo and Schreiber, Marc}, title = {Multi-pedestrian tracking by moving Bluetooth-LE beacons and stationary receivers}, series = {2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan}, booktitle = {2017 International Conference on Indoor Positioning and Indoor Navigation (IPIN), 18-21 September 2017, Sapporo, Japan}, pages = {1 -- 4}, year = {2017}, language = {en} } @article{LiuSchaapBallemansetal.2017, author = {Liu, Z. and Schaap, K. S. and Ballemans, L. and de Blois, E. and Rohde, M. and Paulßen, Elisabeth}, title = {Measurement of reaction kinetics of [177Lu]Lu-DOTA-TATE using a microfluidic system}, series = {Dalton Transactions}, volume = {46}, journal = {Dalton Transactions}, number = {42}, issn = {1477-9234}, doi = {10.1039/C7DT01830D}, pages = {14669 -- 14676}, year = {2017}, language = {en} } @inproceedings{ThurnBalcGebhardtetal.2017, author = {Thurn, Laura and Balc, Nicolae and Gebhardt, Andreas and Kessler, Julia}, title = {Education packed in technology to promote innovations: Teaching Additive Manufacturing based on a rolling Lab}, series = {Modern Technologies in Manufacturing (MTeM 2017 - AMaTUC)}, booktitle = {Modern Technologies in Manufacturing (MTeM 2017 - AMaTUC)}, issn = {2261-236X}, doi = {10.1051/matecconf/201713702013}, pages = {6 Seiten}, year = {2017}, language = {en} } @inproceedings{FunkeKeinzHendrick2017, author = {Funke, Harald and Keinz, Jan and Hendrick, P.}, title = {Experimental Evaluation of the Pollutant and Noise Emissions of the GTCP 36-300 Gas Turbine Operated with Kerosene and a Low NOX Micromix Hydrogen Combustor}, series = {7th European Conference for Aeronautics and Space Sciences, EUCASS 2017}, booktitle = {7th European Conference for Aeronautics and Space Sciences, EUCASS 2017}, organization = {7th European Conference for Aeronautics and Space Sciences, EUCASS 2017-125, Milan, Italy, July 2017}, doi = {10.13009/EUCASS2017-125}, pages = {10 Seiten}, year = {2017}, language = {en} } @inproceedings{SauerbornLiebenstundRaueetal.2017, author = {Sauerborn, Markus and Liebenstund, Lena and Raue, Markus and Mang, Thomas and Herrmann, Ulf and Dueing, Andreas}, title = {Analytic method for material aging and quality analyzing to forecast long time stability of plastic micro heliostat components}, series = {AIP Conference Proceedings}, volume = {1850}, booktitle = {AIP Conference Proceedings}, number = {1}, doi = {10.1063/1.4984388}, pages = {030045-1 -- 030045-8}, year = {2017}, language = {en} } @incollection{HerrmannKearneyRoegeretal.2017, author = {Herrmann, Ulf and Kearney, D. and R{\"o}ger, M. and Prahl, C.}, title = {System performance measurements}, series = {The Performance of Concentrated Solar Power (CSP) Systems : Modelling, Measurement and Assessment}, booktitle = {The Performance of Concentrated Solar Power (CSP) Systems : Modelling, Measurement and Assessment}, publisher = {Woodhead Publishing}, address = {Duxford}, isbn = {978-0-08-100448-7}, doi = {https://doi.org/10.1016/B978-0-08-100447-0.00005-5}, pages = {115 -- 165}, year = {2017}, abstract = {This chapter introduces performance and acceptance testing and describes state-of-the-art tools, methods, and instruments to assess the plant performance or realize plant acceptance testing. The status of the development of standards for performance assessment is given.}, language = {en} } @incollection{KrollLudwigs2017, author = {Kroll-Ludwigs, Kathrin}, title = {Names of individuals}, series = {European Encyclopedia of Private International Law}, booktitle = {European Encyclopedia of Private International Law}, publisher = {Edward Elgar Publishing}, address = {Cheltenham, UK}, isbn = {9781782547228}, year = {2017}, language = {en} } @incollection{KrollLudwigs2017, author = {Kroll-Ludwigs, Kathrin}, title = {Small Claims Regulation}, series = {European Encyclopedia of Private International Law}, booktitle = {European Encyclopedia of Private International Law}, publisher = {Edward Elgar Publishing}, address = {Cheltenham, UK}, isbn = {9781782547228}, year = {2017}, language = {en} } @incollection{AltherrDoerigEdereretal.2017, author = {Altherr, Lena and D{\"o}rig, Bastian and Ederer, Thorsten and Pelz, Peter Franz and Pfetsch, Marc and Wolf, Jan}, title = {A mixed-integer nonlinear program for the design of gearboxes}, series = {Operations Research Proceedings 2016}, booktitle = {Operations Research Proceedings 2016}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-55701-4}, doi = {10.1007/978-3-319-55702-1_31}, pages = {227 -- 233}, year = {2017}, abstract = {Gearboxes are mechanical transmission systems that provide speed and torque conversions from a rotating power source. Being a central element of the drive train, they are relevant for the efficiency and durability of motor vehicles. In this work, we present a new approach for gearbox design: Modeling the design problem as a mixed-integer nonlinear program (MINLP) allows us to create gearbox designs from scratch for arbitrary requirements and—given enough time—to compute provably globally optimal designs for a given objective. We show how different degrees of freedom influence the runtime and present an exemplary solution.}, language = {en} } @inproceedings{AltherrEdererSchaenzleetal.2017, author = {Altherr, Lena and Ederer, Thorsten and Sch{\"a}nzle, Christian and Lorenz, Ulf and Pelz, Peter F.}, title = {Algorithmic system design using scaling and affinity laws}, series = {Operations Research Proceedings 2015}, booktitle = {Operations Research Proceedings 2015}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-42901-4}, doi = {10.1007/978-3-319-42902-1}, pages = {605 -- 611}, year = {2017}, abstract = {Energy-efficient components do not automatically lead to energy-efficient systems. Technical Operations Research (TOR) shifts the focus from the single component to the system as a whole and finds its optimal topology and operating strategy simultaneously. In previous works, we provided a preselected construction kit of suitable components for the algorithm. This approach may give rise to a combinatorial explosion if the preselection cannot be cut down to a reasonable number by human intuition. To reduce the number of discrete decisions, we integrate laws derived from similarity theory into the optimization model. Since the physical characteristics of a production series are similar, it can be described by affinity and scaling laws. Making use of these laws, our construction kit can be modeled more efficiently: Instead of a preselection of components, it now encompasses whole model ranges. This allows us to significantly increase the number of possible set-ups in our model. In this paper, we present how to embed this new formulation into a mixed-integer program and assess the run time via benchmarks. We present our approach on the example of a ventilation system design problem.}, language = {en} } @inproceedings{AltherrEdererFarnetaneetal.2017, author = {Altherr, Lena and Ederer, Thorsten and Farnetane, Lucas S. and P{\"o}ttgen, Philipp and Verg{\´e}, Angela and Pelz, Peter F.}, title = {Multicriterial design of a hydrostatic transmission system via mixed-integer programming}, series = {Operations Research Proceedings 2015}, booktitle = {Operations Research Proceedings 2015}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-42901-4}, doi = {10.1007/978-3-319-42902-1_41}, pages = {301 -- 307}, year = {2017}, abstract = {In times of planned obsolescence the demand for sustainability keeps growing. Ideally, a technical system is highly reliable, without failures and down times due to fast wear of single components. At the same time, maintenance should preferably be limited to pre-defined time intervals. Dispersion of load between multiple components can increase a system's reliability and thus its availability inbetween maintenance points. However, this also results in higher investment costs and additional efforts due to higher complexity. Given a specific load profile and resulting wear of components, it is often unclear which system structure is the optimal one. Technical Operations Research (TOR) finds an optimal structure balancing availability and effort. We present our approach by designing a hydrostatic transmission system.}, language = {en} } @incollection{SteuerDankertBouffierGaedickeetal.2017, author = {Steuer-Dankert, Linda and Bouffier, Anna and Gaedicke, Sonja and Leicht-Scholten, Carmen}, title = {Diversifying engineering education: a transdisciplinary approach from RWTH Aachen University}, series = {Strategies for increasing diversity in engineering majors and careers}, booktitle = {Strategies for increasing diversity in engineering majors and careers}, publisher = {IGI Global}, address = {Hershey, USA}, isbn = {9781522522126}, doi = {10.4018/978-1-5225-2212-6.ch010}, pages = {201 -- 235}, year = {2017}, abstract = {Engineers and therefore engineering education are challenged by the increasing complexity of questions to be answered globally. The education of future engineers therefore has to answer with curriculums that build up relevant skills. This chapter will give an example how to bring engineering and social responsibility successful together to build engineers of tomorrow. Through the integration of gender and diversity perspectives, engineering research and teaching is expanded with new perspectives and contents providing an important potential for innovation. Aiming on the enhancement of engineering education with distinctive competencies beyond technical expertise, the teaching approach introduced in the chapter represents key factors to ensure that coming generations of engineers will be able to meet the requirements and challenges a changing globalized world holds for them. The chapter will describe how this approach successfully has been implemented in the curriculum in engineering of a leading technical university in Germany.}, language = {en} } @inproceedings{CzarneckiDietze2017, author = {Czarnecki, Christian and Dietze, Christian}, title = {Domain-Specific reference modeling in the telecommunications industry}, series = {DESRIST 2017: Designing the Digital Transformation}, booktitle = {DESRIST 2017: Designing the Digital Transformation}, editor = {Maedche, Alexander and vom Brocke, Jan and Hevner, Alan}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-59144-5}, doi = {10.1007/978-3-319-59144-5_19}, pages = {313 -- 329}, year = {2017}, abstract = {The telecommunications industry is currently going through a major transformation. In this context, the enhanced Telecom Operations Map (eTOM) is a domain-specific process reference model that is offered by the industry organization TM Forum. In practice, eTOM is well accepted and confirmed as de facto standard. It provides process definitions and process flows on different levels of detail. This article discusses the reference modeling of eTOM, i.e., the design, the resulting artifact, and its evaluation based on three project cases. The application of eTOM in three projects illustrates the design approach and concrete models on strategic and operational levels. The article follows the Design Science Research (DSR) paradigm. It contributes with concrete design artifacts to the transformational needs of the telecommunications industry and offers lessons-learned from a general DSR perspective.}, language = {en} } @book{CzarneckiDietze2017, author = {Czarnecki, Christian and Dietze, Christian}, title = {Reference architecture for the telecommunications industry: Transformation of strategy, organization, processes, data, and applications}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-46755-9 (Print)}, doi = {10.1007/978-3-319-46757-3}, pages = {XXII, 253 Seiten}, year = {2017}, abstract = {This book reflects the tremendous changes in the telecommunications industry in the course of the past few decades - shorter innovation cycles, stiffer competition and new communication products. It analyzes the transformation of processes, applications and network technologies that are now expected to take place under enormous time pressure. The International Telecommunication Union (ITU) and the TM Forum have provided reference solutions that are broadly recognized and used throughout the value chain of the telecommunications industry, and which can be considered the de facto standard. The book describes how these reference solutions can be used in a practical context: it presents the latest insights into their development, highlights lessons learned from numerous international projects and combines them with well-founded research results in enterprise architecture management and reference modeling. The complete architectural transformation is explained, from the planning and set-up stage to the implementation. Featuring a wealth of examples and illustrations, the book offers a valuable resource for telecommunication professionals, enterprise architects and project managers alike.}, language = {en} } @article{KilicRaatschenKoerfgenetal.2017, author = {Kilic, S. A. and Raatschen, Hans-J{\"u}rgen and K{\"o}rfgen, B. and Apaydin, N. M. and Astaneh-Asl, A.}, title = {FE Model of the Fatih Sultan Mehmet Suspension Bridge Using Thin Shell Finite Elements}, series = {Arabian Journal for Science and Engineering}, volume = {42}, journal = {Arabian Journal for Science and Engineering}, number = {3}, publisher = {Springer Nature}, issn = {2191-4281}, doi = {10.1007/s13369-016-2316-y}, pages = {1103 -- 1116}, year = {2017}, abstract = {This paper presents the results of an eigenvalue analysis of the Fatih Sultan Mehmet Bridge. A high-resolution finite element model was created directly from the available design documents. All physical properties of the structural components were included in detail, so no calibration to the measured data was necessary. The deck and towers were modeled with shell elements. A nonlinear static analysis was performed before the eigenvalue calculation. The calculated natural frequencies and corresponding mode shapes showed good agreement with the available measured ambient vibration data. The calculation of the effective modal mass showed that nine modes had single contributions higher than 5 \% of the total mass. They were in a frequency range up to 1.2 Hz. The comparison of the results for the torsional modes especially demonstrated the advantage of using thin shell finite elements over the beam modeling approach.}, language = {en} } @article{DantismTakenagaWagneretal.2017, author = {Dantism, Shahriar and Takenaga, Shoko and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Differential imaging of the metabolism of bacteria and eukaryotic cells based on light-addressable potentiometric sensors}, series = {Electrochimica Acta}, volume = {246}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2017.05.196}, pages = {234 -- 241}, year = {2017}, abstract = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric sensor with an electrolyte/insulator/semiconductor (EIS) structure, which is able to monitor analyte concentrations of (bio-)chemical species in aqueous solutions in a spatially resolved way. Therefore, it is also an appropriate tool to record 2D-chemical images of concentration variations on the sensor surface. In the present work, two differential, LAPS-based measurement principles are introduced to determine the metabolic activity of Escherichia coli (E. coli) K12 and Chinese hamster ovary (CHO) cells as test microorganisms. Hereby, we focus on i) the determination of the extracellular acidification rate (ΔpH/min) after adding glucose solutions to the cell suspensions; and ii) recording the amplitude increase of the photocurrent (Iph) related to the produced acids from E. coli K12 bacteria and CHO cells on the sensor surface by 2D-chemical imaging. For this purpose, 3D-printed multi-chamber structures were developed and mounted on the planar sensor-chip surface to define four independent compartments, enabling differential measurements with varying cell concentrations. The differential concept allows eliminating unwanted drift effects and, with the four-chamber structures, measurements on the different cell concentrations were performed simultaneously, thus reducing also the overall measuring time.}, language = {en} } @article{JildehKirchnerOberlaenderetal.2017, author = {Jildeh, Zaid B. and Kirchner, Patrick and Oberl{\"a}nder, Jan and Kremers, Alexander and Wagner, Torsten and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef}, title = {FEM-based modeling of a calorimetric gas sensor for hydrogen peroxide monitoring}, series = {physica status solidi a : applications and materials sciences}, journal = {physica status solidi a : applications and materials sciences}, number = {Early View}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201600912}, year = {2017}, abstract = {A physically coupled finite element method (FEM) model is developed to study the response behavior of a calorimetric gas sensor. The modeled sensor serves as a monitoring device of the concentration of gaseous hydrogen peroxide (H2 O2) in a high temperature mixture stream in aseptic sterilization processes. The principle of operation of a calorimetric H2 O2 sensor is analyzed and the results of the numerical model have been validated by using previously published sensor experiments. The deviation in the results between the FEM model and experimental data are presented and discussed.}, language = {en} } @article{MolinnusPoghossianKeusgenetal.2017, author = {Molinnus, Denise and Poghossian, Arshak and Keusgen, Michael and Katz, Evgeny and Sch{\"o}ning, Michael Josef}, title = {Coupling of Biomolecular Logic Gates with Electronic Transducers: From Single Enzyme Logic Gates to Sense/Act/Treat Chips}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {8}, publisher = {Wiley}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201700208}, pages = {1840 -- 1849}, year = {2017}, abstract = {The integration of biomolecular logic principles with electronic transducers allows designing novel digital biosensors with direct electrical output, logically triggered drug-release, and closed-loop sense/act/treat systems. This opens new opportunities for advanced personalized medicine in the context of theranostics. In the present work, we will discuss selected examples of recent developments in the field of interfacing enzyme logic gates with electrodes and semiconductor field-effect devices. Special attention is given to an enzyme OR/Reset logic gate based on a capacitive field-effect electrolyte-insulator-semiconductor sensor modified with a multi-enzyme membrane. Further examples are a digital adrenaline biosensor based on an AND logic gate with binary YES/NO output and an integrated closed-loop sense/act/treat system comprising an amperometric glucose sensor, a hydrogel actuator, and an insulin (drug) sensor.}, language = {en} } @incollection{PoghossianSchoening2017, author = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Nanomaterial-Modified Capacitive Field-Effect Biosensors}, series = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)}, booktitle = {Springer Series on Chemical Sensors and Biosensors (Methods and Applications)}, publisher = {Springer}, address = {Berlin, Heidelberg}, doi = {10.1007/5346_2017_2}, pages = {1 -- 25}, year = {2017}, abstract = {The coupling of charged molecules, nanoparticles, and more generally, inorganic/organic nanohybrids with semiconductor field-effect devices based on an electrolyte-insulator-semiconductor (EIS) system represents a very promising strategy for the active tuning of electrochemical properties of these devices and, thus, opening new opportunities for label-free biosensing by the intrinsic charge of molecules. The simplest field-effect sensor is a capacitive EIS sensor, which represents a (bio-)chemically sensitive capacitor. In this chapter, selected examples of recent developments in the field of label-free biosensing using nanomaterial-modified capacitive EIS sensors are summarized. In the first part, we present applications of EIS sensors modified with negatively charged gold nanoparticles for the label-free electrostatic detection of positively charged small proteins and macromolecules, for monitoring the layer-by-layer formation of oppositely charged polyelectrolyte (PE) multilayers as well as for the development of an enzyme-based biomolecular logic gate. In the second part, examples of a label-free detection by means of EIS sensors modified with a positively charged weak PE layer are demonstrated. These include electrical detection of on-chip and in-solution hybridized DNA (deoxyribonucleic acid) as well as an EIS sensor with pH-responsive weak PE/enzyme multilayers for enhanced field-effect biosensing.}, language = {en} } @article{ArreolaKeusgenSchoening2017, author = {Arreola, Julio and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Effect of O2 plasma on properties of electrolyte-insulator-semiconductor structures}, series = {physica status solidi a : applications and materials sciences}, volume = {214}, journal = {physica status solidi a : applications and materials sciences}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201700025}, pages = {Artikel 1700025}, year = {2017}, abstract = {Prior to immobilization of biomolecules or cells onto biosensor surfaces, the surface must be physically or chemically activated for further functionalization. Organosilanes are a versatile option as they facilitate the immobilization through their terminal groups and also display self-assembly. Incorporating hydroxyl groups is one of the important methods for primary immobilization. This can be done, for example, with oxygen plasma treatment. However, this treatment can affect the performance of the biosensors and this effect is not quite well understood for surface functionalization. In this work, the effect of O2 plasma treatment on EIS sensors was investigated by means of electrochemical characterizations: capacitance-voltage (C-V) and constant capacitance (ConCap) measurements. After O2 plasma treatment, the potential of the EIS sensor dramatically shifts to a more negative value. This was successfully reset by using an annealing process.}, language = {en} } @article{MiyamotoHayashiSakamotoetal.2017, author = {Miyamoto, Ko-ichiro and Hayashi, Kosuke and Sakamoto, Azuma and Werner, Frederik and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {A high-Q resonance-mode measurement of EIS capacitive sensor by elimination of series resistance}, series = {Sensor and Actuators B: Chemical}, volume = {248}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.03.002}, pages = {1006 -- 1010}, year = {2017}, abstract = {An EIS capacitive sensor is a semiconductor-based potentiometric sensor, which is sensitive to the ion concentration or pH value of the solution in contact with the sensing surface. To detect a small change in the ion concentration or pH, a small capacitance change must be detected. Recently, a resonance-mode measurement was proposed, in which an inductor was connected to the EIS capacitive sensor and the resonant frequency was correlated with the pH value. In this study, the Q factor of the resonant circuit was enhanced by canceling the internal resistance of the reference electrode and the internal resistance of the inductor coil with the help of a bypass capacitor and a negative impedance converter, respectively. 1\% variation of the signal in the developed system corresponded to a pH change of 3.93 mpH, which was about 1/12 of the conventional method, suggesting a better performance in detection of a small pH change.}, language = {en} } @article{WernerMiyamotoWagneretal.2017, author = {Werner, Frederik and Miyamoto, Ko-ichiro and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor}, series = {Sensor and Actuators B: Chemical}, volume = {248}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.02.057}, pages = {961 -- 965}, year = {2017}, abstract = {To study chemical and biological processes, spatially resolved determination of the concentrations of one or more analyte species is of distinct interest. With a light-addressable potentiometric sensor (LAPS), chemical images can be created, which visualize the concentration distribution above the sensor plate. One important challenge is to achieve a good lateral resolution in order to detect events that take place in a small and limited region. LAPS utilizes a focused light spot to address the measurement region. By moving this light spot along the semiconductor sensor plate, the concentration distribution can be observed. In this study, we show that utilizing a pulse as light excitation instead of a traditionally used continuously modulated light excitation, the lateral resolution can be improved by a factor of 6 or more.}, language = {en} } @article{SchollMoraisGabrieletal.2017, author = {Scholl, Fabio and Morais, Paulo and Gabriel, Rayla and Sch{\"o}ning, Michael Josef and Siqueira, Jose Roberto, Jr. and Caseli, Luciano}, title = {Carbon nanotubes arranged as smart interfaces in lipid Langmuir-Blodgett films enhancing the enzymatic properties of penicillinase for biosensing applications}, series = {Applied Materials \& Interfaces}, volume = {9}, journal = {Applied Materials \& Interfaces}, number = {36}, publisher = {ACS}, address = {Washington}, issn = {1944-8252}, doi = {10.1021/acsami.7b08095}, pages = {31054 -- 31066}, year = {2017}, abstract = {In this paper, carbon nanotubes (CNTs) were incorporated in penicillinase-phospholipid Langmuir and Langmuir-Blodgett (LB) films to enhance the enzyme catalytic properties. Adsorption of the penicillinase and CNTs at dimyristoylphosphatidic acid (DMPA) monolayers at the air-water interface was investigated by surface pressure-area isotherms, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to solid supports through the LB technique, forming mixed DMPA-CNTs-PEN films, which were investigated by quartz crystal microbalance, vibrational spectroscopy, and atomic force microscopy. Enzyme activity was studied with UV-vis spectroscopy and the feasibility of the supramolecular device nanostructured as ultrathin films were essayed in a capacitive electrolyte-insulator-semiconductor (EIS) sensor device. The presence of CNTs in the enzyme-lipid LB film not only tuned the catalytic activity of penicillinase but also helped conserve its enzyme activity after weeks, showing increased values of activity. Viability as penicillin sensor was demonstrated with capacitance/voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results may be related not only to the nanostructured system provided by the film, but also to the synergism between the compounds on the active layer, leading to a surface morphology that allowed a fast analyte diffusion because of an adequate molecular accommodation, which also preserved the penicillinase activity. This work therefore demonstrates the feasibility of employing LB films composed of lipids, CNTs, and enzymes as EIS devices for biosensing applications.}, language = {en} } @article{TranMottaghyArltKoerferetal.2017, author = {Tran, Linda and Mottaghy, K. and Arlt-K{\"o}rfer, Sabine and Waluga, Christian and Behbahani, Mehdi}, title = {An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system}, series = {Biomedizinische Technik}, volume = {62}, journal = {Biomedizinische Technik}, number = {4}, publisher = {De Gruyter}, address = {Berlin}, issn = {0013-5585}, doi = {10.1515/bmt-2015-0034}, pages = {383 -- 392}, year = {2017}, language = {en} } @inproceedings{MiyamotoSutoWerneretal.2017, author = {Miyamoto, Ko-ichiro and Suto, Takeyuki and Werner, Frederik and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Restraining the Diffusion of Photocarriers to Improve the Spatial Resolution of the Chemical Imaging Sensor}, series = {MDPI Proceedings}, volume = {1}, booktitle = {MDPI Proceedings}, number = {4}, doi = {10.3390/proceedings1040477}, pages = {4 Seiten}, year = {2017}, language = {en} } @inproceedings{OberlaenderArreolaHansenetal.2017, author = {Oberl{\"a}nder, Jan and Arreola, Julio and Hansen, Christina and Greeff, Anton and Mayer, Marlena and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Impedimetric Biosensor to Enable Fast Evaluation of Gaseous Sterilization Processes}, series = {MDPI Proceedings}, volume = {1}, booktitle = {MDPI Proceedings}, number = {4}, doi = {10.3390/proceedings1040435}, pages = {4 Seiten}, year = {2017}, language = {en} } @inproceedings{MolinnusHardtKaeveretal.2017, author = {Molinnus, Denise and Hardt, Gabriel and K{\"a}ver, Larissa and Willenberg, Holger S. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Detection of Adrenaline Based on Bioelectrocatalytical System to Support Tumor Diagnostic Technology}, series = {MDPI Proceedings}, booktitle = {MDPI Proceedings}, doi = {10.3390/proceedings1040506}, pages = {4 Seiten}, year = {2017}, language = {en} } @article{MoraisGomesSilvaetal.2017, author = {Morais, Paulo V. and Gomes, Vanderley F., Jr. and Silva, Anielle C. A. and Dantas, Noelio O. and Sch{\"o}ning, Michael Josef and Siqueira, Jos{\´e} R., Jr.}, title = {Nanofilm of ZnO nanocrystals/carbon nanotubes as biocompatible layer for enzymatic biosensors in capacitive field-effect devices}, series = {Journal of Materials Science}, volume = {52}, journal = {Journal of Materials Science}, number = {20}, publisher = {Springer}, address = {Berlin}, issn = {1573-4803}, doi = {10.1007/s10853-017-1369-y}, pages = {12314 -- 12325}, year = {2017}, abstract = {The incorporation of nanomaterials that are biocompatible with different types of biological compounds has allowed the development of a new generation of biosensors applied especially in the biomedical field. In particular, the integration of film-based nanomaterials employed in field-effect devices can be interesting to develop biosensors with enhanced properties. In this paper, we studied the fabrication of sensitive nanofilms combining ZnO nanocrystals and carbon nanotubes (CNTs), prepared by means of the layer-by-layer (LbL) technique, in a capacitive electrolyte-insulator-semiconductor (EIS) structure for detecting glucose and urea. The ZnO nanocrystals were incorporated in a polymeric matrix of poly(allylamine) hydrochloride (PAH), and arranged with multi-walled CNTs in a LbL PAH-ZnO/CNTs film architecture onto EIS chips. The electrochemical characterizations were performed by capacitance-voltage and constant capacitance measurements, while the morphology of the films was characterized by atomic force microscopy. The enzymes glucose oxidase and urease were immobilized on film's surface for detection of glucose and urea, respectively. In order to obtain glucose and urea biosensors with optimized amount of sensitive films, we investigated the ideal number of bilayers for each detection system. The glucose biosensor showed better sensitivity and output signal for an LbL PAH-ZnO/CNTs nanofilm with 10 bilayers. On the other hand, the urea biosensor presented enhanced properties even for the first bilayer, exhibiting high sensitivity and output signal. The presence of the LbL PAH-ZnO/CNTs films led to biosensors with better sensitivity and enhanced response signal, demonstrating that the adequate use of nanostructured films is feasible for proof-of-concept biosensors with improved properties that may be employed for biomedical applications.}, language = {en} } @article{HonarvarfardGamellaPoghossianetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer}, series = {Applied Materials Today}, volume = {9}, journal = {Applied Materials Today}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-9407}, doi = {10.1016/j.apmt.2017.08.003}, pages = {266 -- 270}, year = {2017}, abstract = {An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte-insulator-semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} }