@article{SeiblerKleinriddersKueterLuksetal.2007,
  author    = {Seibler, Jost and Kleinridders, Andre and K{\"u}ter-Luks, Birgit and Niehaves, Sandra and Br{\"u}ning, Jens C. and Schwenk, Frieder},
  title     = {Reversible gene knockdown in mice using a tight, inducible shRNA expression system},
  series = {Nucleic Acids Research},
  volume    = {35},
  journal   = {Nucleic Acids Research},
  number    = {7},
  issn      = {1362-4962},
  doi       = {10.1093/nar/gkm122},
  pages     = {e54},
  year      = {2007},
  language  = {en}
}
@article{SeiblerBode1997,
  author    = {Seibler, Jost and Bode, J{\"u}rgen},
  title     = {Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay},
  series = {Biochemistry},
  volume    = {36},
  journal   = {Biochemistry},
  number    = {7},
  issn      = {1520-4995},
  pages     = {1740 -- 1747},
  year      = {1997},
  language  = {en}
}
@article{SchwabHojdisLacayoetal.2016,
  author    = {Schwab, Lukas and Hojdis, Nils and Lacayo, Jorge and Wilhelm, Manfred},
  title     = {Fourier-Transform Rheology of Unvulcanized, Carbon Black Filled Styrene Butadiene Rubber},
  series = {Macromolecular Materials and Engineering},
  volume    = {301},
  journal   = {Macromolecular Materials and Engineering},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1439-2054},
  doi       = {10.1002/mame.201500356},
  pages     = {457 -- 468},
  year      = {2016},
  abstract  = {Rubber materials filled with reinforcing fillers display nonlinear rheological behavior at small strain amplitudes below γ0 < 0.1. Nevertheless, rheological data are analyzed mostly in terms of linear parameters, such as shear moduli (G′, G″), which loose their physical meaning in the nonlinear regime. In this work styrene butadiene rubber filled with carbon black (CB) under large amplitude oscillatory shear (LAOS) is analyzed in terms of the nonlinear parameter I3/1. Three different CB grades are used and the filler load is varied between 0 and 70 phr. It is found that I3/1(φ) is most sensitive to changes of the total accessible filler surface area at low strain amplitudes (γ0 = 0.32). The addition of up to 70 phr CB leads to an increase of I3/1(φ) by a factor of more than ten. The influence of the measurement temperature on I3/1 is pronounced for CB levels above the percolation threshold.},
  language  = {en}
}
@article{SchroeterHoffmannVoigtetal.2014,
  author    = {Schroeter, Rebecca and Hoffmann, Tamara and Voigt, Birgit and Meyer, Hanna and Bleisteiner, Monika and Muntel, Jan and J{\"u}rgen, Britta and Albrecht, Dirk and Becher, D{\"o}rte and Lalk, Michael and Evers, Stefan and Bongaerts, Johannes and Maurer, Karl-Heinz and Putzer, Harald and Hecker, Michael and Schweder, Thomas and Bremer, Erhard},
  title     = {Stress responses of the industrial workhorse Bacillus licheniformis to osmotic challenges},
  series = {PLoS ONE},
  volume    = {8},
  journal   = {PLoS ONE},
  number    = {11},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0080956},
  pages     = {e80956},
  year      = {2014},
  abstract  = {The Gram-positive endospore-forming bacterium Bacillus licheniformis can be found widely in nature and it is exploited in industrial processes for the manufacturing of antibiotics, specialty chemicals, and enzymes. Both in its varied natural habitats and in industrial settings, B. licheniformis cells will be exposed to increases in the external osmolarity, conditions that trigger water efflux, impair turgor, cause the cessation of growth, and negatively affect the productivity of cell factories in biotechnological processes. We have taken here both systems-wide and targeted physiological approaches to unravel the core of the osmostress responses of B. licheniformis. Cells were suddenly subjected to an osmotic upshift of considerable magnitude (with 1 M NaCl), and their transcriptional profile was then recorded in a time-resolved fashion on a genome-wide scale. A bioinformatics cluster analysis was used to group the osmotically up-regulated genes into categories that are functionally associated with the synthesis and import of osmostress-relieving compounds (compatible solutes), the SigB-controlled general stress response, and genes whose functional annotation suggests that salt stress triggers secondary oxidative stress responses in B. licheniformis. The data set focusing on the transcriptional profile of B. licheniformis was enriched by proteomics aimed at identifying those proteins that were accumulated by the cells through increased biosynthesis in response to osmotic stress. Furthermore, these global approaches were augmented by a set of experiments that addressed the synthesis of the compatible solutes proline and glycine betaine and assessed the growth-enhancing effects of various osmoprotectants. Combined, our data provide a blueprint of the cellular adjustment processes of B. licheniformis to both sudden and sustained osmotic stress.},
  language  = {en}
}
@article{Schnitzler2009,
  author    = {Schnitzler, Thomas},
  title     = {Cultivation of hybridoma cell line CF-10H5 (DSMZ ACC477)},
  series = {Application notes / Sartorius stedim biotech},
  journal   = {Application notes / Sartorius stedim biotech},
  pages     = {1 -- 4},
  year      = {2009},
  language  = {en}
}
@inproceedings{SchnabelBerndt1973,
  author    = {Schnabel, Eberhard and Berndt, Heinz},
  title     = {Zur selektive Abspaltbarkeit der t-Butyloxycarbonylgruppe},
  series = {Peptides 1971 : proceedings of the Eleventh European Peptide Symposium, Vienna, Austria, April 1971},
  booktitle = {Peptides 1971 : proceedings of the Eleventh European Peptide Symposium, Vienna, Austria, April 1971},
  editor    = {Nesvadba, H.},
  publisher = {North-Holland Publ. [u.a.]},
  address   = {Amsterdam [u.a.]},
  isbn      = {0-7204-4120-X},
  pages     = {69 -- 70},
  year      = {1973},
  language  = {en}
}
@article{SchmitzHirschBongaertsetal.2002,
  author    = {Schmitz, M. and Hirsch, E. and Bongaerts, Johannes and Takors, Ralf},
  title     = {Pulse experiments as a prerequisite for the quantification of in vivo enzyme kinetics in aromatic amino acid pathway of Eschericia coli},
  series = {Biotechnology progress},
  volume    = {Vol. 18},
  journal   = {Biotechnology progress},
  number    = {Iss. 5},
  issn      = {1520-6033 (E-Journal); 8756-7938 (Print)},
  pages     = {935 -- 941},
  year      = {2002},
  language  = {en}
}
@article{SchmidtTurgutLeetal.2020,
  author    = {Schmidt, Aaron C. and Turgut, Hatice and Le, Dao and Beloqui, Ana and Delaittre, Guillaume},
  title     = {Making the best of it: nitroxide-mediated polymerization of methacrylates via the copolymerization approach with functional styrenics},
  series = {Polymer Chemistry},
  volume    = {11},
  journal   = {Polymer Chemistry},
  number    = {2},
  publisher = {Royal Society of Chemistry (RSC)},
  address   = {Cambridge},
  doi       = {10.1039/C9PY01458F},
  pages     = {593 -- 604},
  year      = {2020},
  abstract  = {The SG1-mediated solution polymerization of methyl methacrylate (MMA) and oligo(ethylene glycol) methacrylate (OEGMA, Mₙ = 300 g mol⁻¹) in the presence of a small amount of functional/reactive styrenic comonomer is investigated. Moieties such as pentafluorophenyl ester, triphenylphosphine, azide, pentafluorophenyl, halide, and pyridine are considered. A comonomer fraction as low as 5 mol\% typically results in a controlled/living behavior, at least up to 50\% conversion. Chain extensions with styrene for both systems were successfully performed. Variation of physical properties such as refractive index (for MMA) and phase transition temperature (for OEGMA) were evaluated by comparing to 100\% pure homopolymers. The introduction of an activated ester styrene derivative in the polymerization of OEGMA allows for the synthesis of reactive and hydrophilic polymer brushes with defined thickness. Finally, using the example of pentafluorostyrene as controlling comonomer, it is demonstrated that functional PMMA-b-PS are able to maintain a phase separation ability, as evidenced by the formation of nanostructured thin films.},
  language  = {en}
}
@article{SchmichEdererEbert1992,
  author    = {Schmich, Peter and Ederer, Hanns J. and Ebert, Klaus H.},
  title     = {Detection and identification of free radicals in hydrocarbon pyrolysis by an iodine trapping method},
  series = {Industrial \& Engineering Chemistry Research. 31 (1992), H. 1},
  journal   = {Industrial \& Engineering Chemistry Research. 31 (1992), H. 1},
  isbn      = {1520-5045},
  pages     = {29 -- 37},
  year      = {1992},
  language  = {en}
}
@article{SchiffelsSelmer2015,
  author    = {Schiffels, Johannes and Selmer, Thorsten},
  title     = {A flexible toolbox to study protein-assisted metalloenzyme assembly in vitro},
  series = {Biotechnology and Bioengineering},
  volume    = {112},
  journal   = {Biotechnology and Bioengineering},
  number    = {11},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1097-0290},
  doi       = {10.1002/bit.25658},
  pages     = {2360 -- 2372},
  year      = {2015},
  language  = {en}
}
@article{SchiffelsSelmer2019,
  author    = {Schiffels, Johannes and Selmer, Thorsten},
  title     = {Combinatorial assembly of ferredoxin-linked modules in Escherichia coli yields a testing platform for Rnf-complexes},
  series = {Biotechnology and Bioengineering},
  journal   = {Biotechnology and Bioengineering},
  number    = {accepted article},
  publisher = {Wiley},
  address   = {Weinheim},
  doi       = {10.1002/bit.27079},
  pages     = {1 -- 36},
  year      = {2019},
  language  = {en}
}
@article{SchiffelsPinkenburgScheldenetal.2013,
  author    = {Schiffels, Johannes and Pinkenburg, Olaf and Schelden, Maximilian and Aboulnaga, El-Hussiny A. A. and Baumann, Marcus and Selmer, Thorsten},
  title     = {An innovative cloning platform enables large-scale production and maturation of an oxygen-tolerant [NiFe]-hydrogenase from cupriavidus necator in Escherichia coli},
  series = {PLOS one. 2013},
  journal   = {PLOS one. 2013},
  publisher = {Public Library of Science},
  address   = {San Francisco, California},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0068812},
  year      = {2013},
  language  = {en}
}
@article{SchiffelsBaumannSelmer2011,
  author    = {Schiffels, Johannes and Baumann, Marcus and Selmer, Thorsten},
  title     = {Facile analysis of short-chain fatty acids as 4-nitrophenyl esters in complex anaerobic fermentation samples by high performance liquid chromatography},
  series = {Journal of Chromatography A. 1218 (2011), H. 34},
  journal   = {Journal of Chromatography A. 1218 (2011), H. 34},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0021-9673},
  pages     = {5848 -- 5851},
  year      = {2011},
  language  = {en}
}
@article{SchiedermeierRettnerHeilmannetal.2019,
  author    = {Schiedermeier, Maximilian and Rettner, Cornelius and Heilmann, Marcel and Schneider, Felix and Marz, Martin},
  title     = {Interference of automotive HV-DC-systems by traction voltage-source-inverters (VSI)},
  series = {2019 IEEE Transportation Electrification Conference (ITEC-India)},
  journal   = {2019 IEEE Transportation Electrification Conference (ITEC-India)},
  publisher = {IEEE},
  address   = {New York},
  doi       = {10.1109/ITEC-India48457.2019.ITECINDIA2019-37},
  pages     = {1 -- 6},
  year      = {2019},
  language  = {en}
}
@article{SchererZimmermannGoberetal.1993,
  author    = {Scherer, Ulrich W. and Zimmermann, H. P. and Gober, M. K. and Kratz, J. V.},
  title     = {Chemical Properties of Element 105 in Aqueous Solution: Back Extraction from Triisooctyl Amine into 0.5M HCl / H.P. Zimmermann, M.K. Gober, J.V. Kratz, M. Sch{\"a}del, E. Schimpf, K.E. Gregorich, A. T{\"u}rler, K.R. Czerwinski, N.J. Hannink, B. Kadkhodayan, D.M.},
  series = {Radiochimica Acta. 60 (1993)},
  journal   = {Radiochimica Acta. 60 (1993)},
  isbn      = {0033-8230},
  pages     = {11},
  year      = {1993},
  language  = {en}
}
@article{SchererTuerlerGaeggeleretal.1988,
  author    = {Scherer, Ulrich W. and T{\"u}rler, A. and G{\"a}ggeler, H. W. and Jost, D. T.},
  title     = {Determination of the Partial Electron-Capture- and Spontaneous-Fission Half-Lives of 254No / A. T{\"u}rler, H.W. G{\"a}ggeler, D.T. Jost, P. Armbruster, W. Br{\"u}chle, H. Folger, F.P. Heßberger, S. Hofmann,},
  series = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 331 (1988), H. 3},
  journal   = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 331 (1988), H. 3},
  isbn      = {0939-7922},
  pages     = {363 -- 364},
  year      = {1988},
  language  = {en}
}
@article{SchererTuerlerGaeggeleretal.1992,
  author    = {Scherer, Ulrich W. and T{\"u}rler, A. and G{\"a}ggeler, H. W. and Gregorich, K. E.},
  title     = {Gas phase chromatography of halides of elements 104 and 105 / A. T{\"u}rler, H. W. G{\"a}ggeler, K. E. Gregorich, H. Barth, W. Br{\"u}chle, K. R. Czerwinski, M. K. Gober, N. J. Hannink, R. A. Henderson, D. C. Hoffman, D. T. Jost, C. D. Kacher, B. Kadkhodayan, J. Kova},
  series = {Journal of Radioanalytical and Nuclear Chemistry. 160 (1992), H. 2},
  journal   = {Journal of Radioanalytical and Nuclear Chemistry. 160 (1992), H. 2},
  isbn      = {0236-5731},
  pages     = {327 -- 339},
  year      = {1992},
  language  = {en}
}
@article{SchererTomasbergerVeltkampetal.2001,
  author    = {Scherer, Ulrich W. and Tomasberger, T. and Veltkamp, T. C. and Booij, A. S.},
  title     = {Radiocesium Removal from High Level Liquid Waste and Immobilisation in Sodium SilicoTitanate for Geological Disposal / T. Tomasberger, T.C. Veltkamp, A.S. Booij, U.W. Scherer},
  series = {Radiochimica Acta. 89 (2001), H. 3},
  journal   = {Radiochimica Acta. 89 (2001), H. 3},
  isbn      = {0033-8230},
  pages     = {145 -- 150},
  year      = {2001},
  language  = {en}
}
@article{SchererSrivastavaSinghetal.2006,
  author    = {Scherer, Ulrich W. and Srivastava, Alok and Singh, Vivendra and Chandra, Amita},
  title     = {Electrical conductivity studies of swift heavy ion modified PVC and PVC-PANI composite / Alok Srivastava ,Virendra Singh, Amita Chandra, K.Witte, U.W.Scherer and T.V.Singh},
  series = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 245 (2006), H. 1},
  journal   = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 245 (2006), H. 1},
  isbn      = {0168-583X},
  pages     = {277 -- 280},
  year      = {2006},
  language  = {en}
}
@article{SchererSchaedelBruechleetal.1992,
  author    = {Scherer, Ulrich W. and Sch{\"a}del, M. and Br{\"u}chle, W. and Schimpf, E.},
  title     = {Chemical Properties of Element 105 in Aqueous Solution: Cation Exchange Separations with \&\#945;-Hydroxyisobutyric Acid / M. Sch{\"a}del, W. Br{\"u}chle, E. Schimpf, H.P. Zimmermann, M.K. Gober, J.V. Kratz, N. Trautmann, H. G{\"a}ggeler, D. Jost, J. Kovacs, U.W. Sche},
  series = {Radiochimica Acta. 57 (1992)},
  journal   = {Radiochimica Acta. 57 (1992)},
  isbn      = {0033-8230},
  pages     = {85 -- 92},
  year      = {1992},
  language  = {en}
}
@article{SchererSchaedelBruechleetal.1989,
  author    = {Scherer, Ulrich W. and Sch{\"a}del, M. and Br{\"u}chle, W. and J{\"a}ger, E.},
  title     = {ARCA II - A New Apparatus for Fast Repetitive HPLC-Separations / M. Sch{\"a}del, W. Br{\"u}chle, E. J{\"a}ger, E. Schimpf, J.V. Kratz, U.W. Scherer, H.P. Zimmermann},
  series = {Radiochimica Acta. 48 (1989)},
  journal   = {Radiochimica Acta. 48 (1989)},
  isbn      = {0033-8230},
  pages     = {171},
  year      = {1989},
  language  = {en}
}
@article{SchererSantanaMaieretal.2009,
  author    = {Scherer, Ulrich W. and Santana, H. H. S. and Maier, G. and Rodenas, J.},
  title     = {Analysis of mechanical strength in ceramic pellets of nuclear fuel / Santana, H. H. S. ; Maier, G. ; Scherer, U. W. ; Rodenas, J.},
  series = {Radiation effects and defects in solids. 164 (2009), H. 5-6},
  journal   = {Radiation effects and defects in solids. 164 (2009), H. 5-6},
  publisher = {Taylor \& Francis},
  address   = {London},
  isbn      = {1042-0150},
  pages     = {313 -- 318},
  year      = {2009},
  language  = {en}
}
@article{SchererKratzZimmermannetal.1989,
  author    = {Scherer, Ulrich W. and Kratz, J. V. and Zimmermann, H. P. and Sch{\"a}del, M.},
  title     = {Chemical Properties of Element 105 in Aqueous Solutions: Halide Complex Formation and Anion Exchange into Triisooctylamine / J.V. Kratz, H.P. Zimmermann, U.W. Scherer, M. Sch{\"a}del, W. Br{\"u}chle, K.E. Gregorich, C.M. Gannett, H.L. Hall, R.A. Henderson, D.M. L},
  series = {Radiochimica Acta. 48 (1989)},
  journal   = {Radiochimica Acta. 48 (1989)},
  isbn      = {0033-8230},
  pages     = {121},
  year      = {1989},
  language  = {en}
}
@article{SchererKratzSchaedeletal.1988,
  author    = {Scherer, Ulrich W. and Kratz, J. V. and Sch{\"a}del, M. and Br{\"u}chle, W.},
  title     = {Lawrencium Chemistry: No Evidence for Oxidation States Lower than 3+ in Aqueous Solution / U.W. Scherer, J.V. Kratz, M. Sch{\"a}del, W. Br{\"u}chle, K.E. Gregorich, R.A. Henderson, D. Lee, M. Nurmia, D.C. Hoffman},
  series = {Inorganica Chimica Acta. 146 (1988)},
  journal   = {Inorganica Chimica Acta. 146 (1988)},
  isbn      = {0020-1693},
  pages     = {249 -- 254},
  year      = {1988},
  language  = {en}
}
@article{SchererKratzGoberetal.1992,
  author    = {Scherer, Ulrich W. and Kratz, J. V. and Gober, M. K. and Zimmermann, H. P.},
  title     = {New nuclide 263 105 / J.V. Kratz, M.K. Gober, H.P. Zimmermann, M. Sch{\"a}del, W. Br{\"u}chle, E. Schimpf, K.E. Gregorich, A. T{\"u}rler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M.J. Nurmia, D.C. Hoffman, H. G{\"a}ggeler, D. Jost, U.W. Scherer, A. Weber},
  series = {Physical Review C . 45 (1992)},
  journal   = {Physical Review C . 45 (1992)},
  pages     = {1064 -- 1069},
  year      = {1992},
  language  = {en}
}
@article{SchererJacobiCastilloetal.2009,
  author    = {Scherer, Ulrich W. and Jacobi, M. and Castillo, J. and Foerstel, D. H.},
  title     = {Ultra-low-level measurements of 3H and 14C in wines and champagne / Scherer, U. W. ; Jacobi, M. ; Castillo, J. ; Foerstel, D. H.},
  series = {Radiation effects and defects in solids. 164 (2009), H. 5-6},
  journal   = {Radiation effects and defects in solids. 164 (2009), H. 5-6},
  isbn      = {1042-0150},
  pages     = {382 -- 385},
  year      = {2009},
  language  = {en}
}
@article{SchererHoerKranertetal.1998,
  author    = {Scherer, Ulrich W. and H{\"o}r, G. and Kranert, W. T. and Maul, F. D.},
  title     = {Gated Metabolic Positron Emission Tomography (GAPET) of Myocardium: 18F-FDG/PET to optimize Recognition of Myocardial Hibernation / G. H{\"o}r, W.T. Kranert, F.D. Maul, O. Schr{\"o}der, A. Karimian-Tatriz, O. Geb, R.P. Baum, U.W. Scherer},
  series = {Nuclear Medicine Communications. 19 (1998)},
  journal   = {Nuclear Medicine Communications. 19 (1998)},
  isbn      = {0143-3636},
  pages     = {535 -- 545},
  year      = {1998},
  language  = {en}
}
@article{SchererHoer1997,
  author    = {Scherer, Ulrich W. and H{\"o}r, G.},
  title     = {Artifacts and Pitfalls in FDG-PET Whole-Body Scans / U.W. Scherer, G. H{\"o}r},
  series = {Radionuclides for Mammary Gland - Current Status and Future Aspects / G. S. Limouris [Hrsg.]},
  journal   = {Radionuclides for Mammary Gland - Current Status and Future Aspects / G. S. Limouris [Hrsg.]},
  publisher = {Mediterra Publishers},
  address   = {Athen},
  isbn      = {960-85227-6-5},
  pages     = {37 -- 42},
  year      = {1997},
  language  = {en}
}
@article{SchererHessbergerGaeggeleretal.1989,
  author    = {Scherer, Ulrich W. and Heßberger, F. P. and G{\"a}ggeler, H. W. and Armbruster, P.},
  title     = {The New Nuclide 225U / F.P. Heßberger, H. G{\"a}ggeler, P. Armbruster, W. Br{\"u}chle, H. Folger, S. Hofmann, D. Jost, J.V. Kratz, M.E. Leino, G. M{\"u}nzenberg, V. Ninov, M. Sch{\"a}del, U.W. Scherer, K. S{\"u}mmerer, A. T{\"u}rler, D. Ackerman},
  series = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 333 (1989), H. 1},
  journal   = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 333 (1989), H. 1},
  isbn      = {0939-7922},
  pages     = {111 -- 112},
  year      = {1989},
  language  = {en}
}
@article{SchererGaeggelerJostetal.1989,
  author    = {Scherer, Ulrich W. and G{\"a}ggeler, H. W. and Jost, D. T. and T{\"u}rler, A.},
  title     = {Cold Fusion Reactions with 48Ca / H.W. G{\"a}ggeler, D.T. Jost, A. T{\"u}rler, P. Armbruster, W. Br{\"u}chle, H. Folger, F.P. Heßberger, S. Hofmann, G. M{\"u}nzenberg, V. Ninov, W. Reisdorf, M. Sch{\"a}del, K. S{\"u}mmerer, J.V. Kratz, U. Scherer, M.E. Leino},
  series = {Nuclear Physics A . 502 (1989), H. 1},
  journal   = {Nuclear Physics A . 502 (1989), H. 1},
  isbn      = {0375-9474},
  pages     = {561 -- 570},
  year      = {1989},
  language  = {en}
}
@article{SchererGaeggelerJostetal.1992,
  author    = {Scherer, Ulrich W. and G{\"a}ggeler, H. W. and Jost, D. T. and Kovacs, J.},
  title     = {Gas Phase Chromatography Experiments with Bromides of Tantalum and Element 105 / H.W. G{\"a}ggeler, D.T. Jost, J. Kovacs, U.W. Scherer, A. Weber, D. Vermeulen, A. T{\"u}rler, K.E. Gregorich, R.A. Henderson, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee, M. Nurmia, D.},
  series = {Radiochimica Acta. 57 (1992)},
  journal   = {Radiochimica Acta. 57 (1992)},
  isbn      = {0033-8230},
  pages     = {93 -- 100},
  year      = {1992},
  language  = {en}
}
@article{SchererGoberKratzetal.1992,
  author    = {Scherer, Ulrich W. and Gober, M. K. and Kratz, J. V. and Zimmermann, H. P.},
  title     = {Chemical Properties of Element 105 in Aqueous Solution: Extractions into Diisobutylcarbinol / M.K. Gober, J.V. Kratz, H.P. Zimmermann, M. Sch{\"a}del, W. Br{\"u}chle, E. Schimpf, K.E. Gregorich, A. T{\"u}rler, N.J. Hannink, K.R. Czerwinski, B. Kadkhodayan, D.M. Lee,},
  series = {Radiochimica Acta. 57 (1992)},
  journal   = {Radiochimica Acta. 57 (1992)},
  isbn      = {0033-8230},
  pages     = {77 -- 84},
  year      = {1992},
  language  = {en}
}
@article{SchererBruechleSchaedeletal.1988,
  author    = {Scherer, Ulrich W. and Br{\"u}chle, W. and Sch{\"a}del, M. and Kratz, J. V.},
  title     = {The Hydration Enthalpies of Md3+ and Lr3+ / W. Br{\"u}chle, M. Sch{\"a}del, U.W. Scherer, J.V. Kratz, K.E. Gregorich, D. Lee, M. Nurmia, R.M. Chasteler, H.L. Hall, R.A. Henderson, D.C. Hoffman},
  series = {Inorganica Chimica Acta. 146 (1988), H. 2},
  journal   = {Inorganica Chimica Acta. 146 (1988), H. 2},
  isbn      = {0020-1693},
  pages     = {267 -- 276},
  year      = {1988},
  language  = {en}
}
@article{SchererBruechleBrueggeretal.1990,
  author    = {Scherer, Ulrich W. and Br{\"u}chle, W. and Br{\"u}gger, M. and Frink, C.},
  title     = {Reactions of 40Ar with 233U,,235U, and 238U at the Barrier / U.W. Scherer, W. Br{\"u}chle, M. Br{\"u}gger, C. Frink, H. G{\"a}ggeler, G. Herrmann, J.V. Kratz, K.J. Moody, M. Sch{\"a}del, K. S{\"u}mmerer, N. Trautmann, G. Wirth},
  series = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 335 (1990), H. 4},
  journal   = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 335 (1990), H. 4},
  isbn      = {0939-7922},
  pages     = {421 -- 430},
  year      = {1990},
  language  = {en}
}
@article{SchererBaltenspergerAmmannetal.1993,
  author    = {Scherer, Ulrich W. and Baltensperger, Urs and Ammann, Markus and Bochert, Ulrich K.},
  title     = {Use of 13N for Studies of the Selective Reduction of NO by NH3 over Vanadia/Titania Catalyst at Very Low Reactant Concentrations / Urs Baltensperger, Markus Ammann, Ulrich K. Bochert, Bernd Eichler, Heinz W. G{\"a}ggeler, Dieter T. Jost, Joseph A. Kovacs, An},
  series = {Journal of Physical Chemistry. 97 (1993)},
  journal   = {Journal of Physical Chemistry. 97 (1993)},
  isbn      = {0022-3654},
  pages     = {12325 -- 12330},
  year      = {1993},
  language  = {en}
}
@article{Scherer2006,
  author    = {Scherer, Ulrich W.},
  title     = {Controlled ion track etching / J. George; M. Irkens ; S. Neumann ; U. W. Scherer ; A. Srivastava ; D. Sinha ; D. Fink},
  series = {Radiation Effects and Defects in Solids. 161 (2006), H. 3},
  journal   = {Radiation Effects and Defects in Solids. 161 (2006), H. 3},
  pages     = {161 -- 175},
  year      = {2006},
  language  = {en}
}
@article{ScheerWolf2014,
  author    = {Scheer, Nico and Wolf, C. Roland},
  title     = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications},
  series = {Xenobiotica},
  volume    = {44},
  journal   = {Xenobiotica},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1366-5928},
  doi       = {10.3109/00498254.2013.815831},
  pages     = {96 -- 108},
  year      = {2014},
  abstract  = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.},
  language  = {en}
}
@article{ScheerWolf2013,
  author    = {Scheer, Nico and Wolf, C. Roland},
  title     = {Xenobiotic receptor humanized mice and their utility},
  series = {Drug Metabolism Reviews},
  journal   = {Drug Metabolism Reviews},
  number    = {1},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1097-9883},
  doi       = {10.3109/03602532.2012.738687},
  pages     = {110 -- 121},
  year      = {2013},
  language  = {en}
}
@article{ScheerWilson2016,
  author    = {Scheer, Nico and Wilson, Ian D.},
  title     = {A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity},
  series = {Drug Discovery Today},
  volume    = {21},
  journal   = {Drug Discovery Today},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1359-6446},
  doi       = {10.1016/j.drudis.2015.09.002},
  pages     = {250 -- 263},
  year      = {2016},
  abstract  = {Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug-drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.},
  language  = {en}
}
@article{ScheerSnaithWolfetal.2013,
  author    = {Scheer, Nico and Snaith, Mike and Wolf, C. Roland and Seibler, Jost},
  title     = {Generation and utility of genetically humanized mouse models},
  series = {Drug Discovery Today},
  volume    = {Vol 18},
  journal   = {Drug Discovery Today},
  number    = {23-24},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1359-6446},
  doi       = {10.1016/j.drudis.2013.07.007},
  pages     = {1200 -- 1211},
  year      = {2013},
  language  = {en}
}
@article{ScheerRossRodeetal.2008,
  author    = {Scheer, Nico and Ross, Jillian and Rode, Anja and Zevnik, Branko and Niehaves, Sandra and Faust, Nicole and Wolf, C. Roland},
  title     = {A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response},
  series = {Journal of Clinical Investigation},
  volume    = {118},
  journal   = {Journal of Clinical Investigation},
  number    = {9},
  issn      = {1558-8238},
  doi       = {https://doi.org/10.1172/JCI35483},
  pages     = {3228 -- 3239},
  year      = {2008},
  language  = {en}
}
@article{ScheerRossKapelyukhetal.2010,
  author    = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland},
  title     = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice},
  series = {Drug Metabolism and Disposition},
  volume    = {38},
  journal   = {Drug Metabolism and Disposition},
  number    = {7},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.109.031872},
  pages     = {1046 -- 1053},
  year      = {2010},
  abstract  = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.},
  language  = {en}
}
@article{ScheerRiedlWarrenetal.2002,
  author    = {Scheer, Nico and Riedl, Iris and Warren, J.T. and Kuwada, John Y. and Campos-Ortega, Jos{\´e} A.},
  title     = {A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish},
  series = {Mechanism of Development},
  volume    = {112},
  journal   = {Mechanism of Development},
  number    = {1-2},
  issn      = {0925-4773},
  doi       = {10.1016/S0925-4773(01)00621-9},
  pages     = {9 -- 14},
  year      = {2002},
  language  = {en}
}
@article{ScheerMclaughlinRodeetal.2014,
  author    = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.},
  title     = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057885},
  pages     = {1022 -- 1030},
  year      = {2014},
  abstract  = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.},
  language  = {en}
}
@article{ScheerKapelyukhRodeetal.2015,
  author    = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Oswald, Stefan and Busch, Diana and Mclaughlin, Lesley A. and Lin, De and Henderson, Colin J. and Wolf, C. Roland},
  title     = {Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model},
  series = {Drug Metabolism and Disposition},
  volume    = {43},
  journal   = {Drug Metabolism and Disposition},
  number    = {11},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-009x},
  doi       = {10.1124/dmd.115.065656},
  pages     = {1679 -- 1690},
  year      = {2015},
  language  = {en}
}
@article{ScheerKapelyukhRodeetal.2012,
  author    = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Buechel, Sandra and Wolf, C. Roland},
  title     = {Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines},
  series = {Molecular Pharmacology},
  volume    = {82},
  journal   = {Molecular Pharmacology},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.112.080036},
  pages     = {1022 -- 1029},
  year      = {2012},
  abstract  = {Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction.},
  language  = {en}
}
@article{ScheerKapelyukhMcEwanetal.2012,
  author    = {Scheer, Nico and Kapelyukh, Yury and McEwan, Jillian and Beuger, Vincent and Stanley, Lesley A. and Rode, Anja and Wolf, C. Roland},
  title     = {Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines},
  series = {Molecular Pharmacology},
  volume    = {81},
  journal   = {Molecular Pharmacology},
  number    = {1},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.111.075192},
  pages     = {63 -- 72},
  year      = {2012},
  abstract  = {The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25\% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.},
  language  = {en}
}
@article{ScheerHendersonKapelyukhetal.2019,
  author    = {Scheer, Nico and Henderson, Colin James and Kapelyukh, Yury and Rode, Anja and Mclaren, Aileen W. and MacLeod, Alastair Kenneth and Lin, De and Wright, Jayne and Stanley, Lesley and Wolf, C. Roland},
  title     = {An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials},
  series = {Drug Metabolism and Disposition},
  journal   = {Drug Metabolism and Disposition},
  number    = {Early view},
  doi       = {10.1124/dmd.119.086397},
  pages     = {69 Seiten},
  year      = {2019},
  language  = {en}
}
@article{ScheerGrothHansetal.2001,
  author    = {Scheer, Nico and Groth, Anne and Hans, Stefan and Campos-Ortega, Jos{\´e} A.},
  title     = {An instructive function for Notch in promoting gliogenesis in the zebrafish retina},
  series = {Development},
  volume    = {128},
  journal   = {Development},
  number    = {7},
  issn      = {0950-1991},
  pages     = {1099 -- 1107},
  year      = {2001},
  language  = {en}
}
@incollection{ScheerChuSalphatietal.2016,
  author    = {Scheer, Nico and Chu, Xiaoyan and Salphati, Laurent and Zamek-Gliszczynski, Maciej J.},
  title     = {Knockout and humanized animal models to study membrane transporters in drug development},
  series = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development},
  booktitle = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development},
  editor    = {Nicholls, Glynis},
  publisher = {Royal Society of Chemistry},
  address   = {Cambridge},
  isbn      = {978-1-78262-379-3},
  doi       = {10.1039/9781782623793-00298},
  pages     = {298 -- 332},
  year      = {2016},
  language  = {en}
}