@article{BhattaraiMayStaatetal.2022,
  author    = {Bhattarai, Aroj and May, Charlotte Anabell and Staat, Manfred and Kowalczyk, Wojciech and Tran, Thanh Ngoc},
  title     = {Layer-specific damage modeling of porcine large intestine under biaxial tension},
  series = {Bioengineering},
  volume    = {9},
  journal   = {Bioengineering},
  number    = {10, Early Access},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2306-5354},
  doi       = {10.3390/bioengineering9100528},
  pages     = {1 -- 17},
  year      = {2022},
  abstract  = {The mechanical behavior of the large intestine beyond the ultimate stress has never been investigated. Stretching beyond the ultimate stress may drastically impair the tissue microstructure, which consequently weakens its healthy state functions of absorption, temporary storage, and transportation for defecation. Due to closely similar microstructure and function with humans, biaxial tensile experiments on the porcine large intestine have been performed in this study. In this paper, we report hyperelastic characterization of the large intestine based on experiments in 102 specimens. We also report the theoretical analysis of the experimental results, including an exponential damage evolution function. The fracture energies and the threshold stresses are set as damage material parameters for the longitudinal muscular, the circumferential muscular and the submucosal collagenous layers. A biaxial tensile simulation of a linear brick element has been performed to validate the applicability of the estimated material parameters. The model successfully simulates the biomechanical response of the large intestine under physiological and non-physiological loads.},
  language  = {en}
}
@article{BhattaraiJabbariAndingetal.2018,
  author    = {Bhattarai, Aroj and Jabbari, Medisa and Anding, Ralf and Staat, Manfred},
  title     = {Surgical treatment of vaginal vault prolapse using different prosthetic mesh implants: a finite element analysis},
  series = {tm - Technisches Messen},
  volume    = {85},
  journal   = {tm - Technisches Messen},
  number    = {5},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2196-7113},
  doi       = {10.1515/teme-2017-0115},
  pages     = {331 -- 342},
  year      = {2018},
  abstract  = {Particularly multiparous elderly women may suffer from vaginal vault prolapse after hysterectomy due to weak support from lax apical ligaments. A decreased amount of estrogen and progesterone in older age is assumed to remodel the collagen thereby reducing tissue stiffness. Sacrocolpopexy is either performed as open or laparoscopic surgery using prosthetic mesh implants to substitute lax ligaments. Y-shaped mesh models (DynaMesh, Gynemesh, and Ultrapro) are implanted in a 3D female pelvic floor finite element model in the extraperitoneal space from the vaginal cuff to the first sacral (S1) bone below promontory. Numerical simulations are conducted during Valsalva maneuver with weakened tissues modeled by reduced tissue stiffness. Tissues are modeled as incompressible, isotropic hyperelastic materials whereas the meshes are modeled either as orthotropic linear elastic or as isotropic hyperlastic materials. The positions of the vaginal cuff and the bladder base are calculated from the pubococcygeal line for female pelvic floor at rest, for prolapse and after repair using the three meshes. Due to mesh mechanics and mesh pore deformation along the loaded direction, the DynaMesh with regular rectangular mesh pores is found to provide better mechanical support to the organs than the Gynemesh and the Ultrapro with irregular hexagonal mesh pores. Insbesondere {\"a}ltere, mehrgeb{\"a}hrende Frauen leiden h{\"a}ufiger an einem Scheidenvorfall nach einer Hysterektomie aufgrund der schwachen Unterst{\"u}tzung durch laxe apikale B{\"a}nder. Es wird angenommen, dass eine verringerte Menge an {\"O}strogen und Progesteron im h{\"o}heren Alter das Kollagen umformt, wodurch die Gewebesteifigkeit reduziert wird. Die Sakrokolpopexie ist eine offene oder laparoskopische Operation, die mit prothetischen Netzimplantaten durchgef{\"u}hrt wird, um laxe B{\"a}nder zu ersetzen. Y-f{\"o}rmige Netzmodelle (DynaMesh, Gynemesh und Ultrapro) werden in einem 3D-Modell des weiblichen Beckenbodens im extraperitonealen Raum vom Vaginalstumpf bis zum Promontorium implantiert. Numerische Simulationen werden w{\"a}hrend des Valsalva-Man{\"o}vers mit geschw{\"a}chtem Gewebe durchgef{\"u}hrt, das durch eine reduzierte Gewebesteifigkeit modelliert wird. Die Gewebe werden als inkompressible, isotrop hyperelastische Materialien modelliert, w{\"a}hrend die Netze entweder als orthotrope linear elastische oder als isotrope hyperlastische Materialien modelliert werden. Die Positionen des Vaginalstumpfs, der Blase und der Harnr{\"o}hrenachse werden anhand der Pubococcygeallinie aus der Ruhelage, f{\"u}r den Prolaps und nach der Reparatur unter Verwendung der drei Netze berechnet. Aufgrund der Netzmechanik und der Netzporenverformung bietet das DynaMesh mit regelm{\"a}ßigen rechteckigen Netzporen eine bessere mechanische Unterst{\"u}tzung und eine Neupositionierung des Scheidengew{\"o}lbes, der Blase und der Urethraachse als Gynemesh und Ultrapro mit unregelm{\"a}ßigen hexagonalen Netzporen.},
  language  = {en}
}
@article{BhattaraiHorbachStaatetal.2022,
  author    = {Bhattarai, Aroj and Horbach, Andreas and Staat, Manfred and Kowalczyk, Wojciech and Tran, Thanh Ngoc},
  title     = {Virgin passive colon biomechanics and a literature review of active contraction constitutive models},
  series = {Biomechanics},
  volume    = {2},
  journal   = {Biomechanics},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2673-7078},
  doi       = {10.3390/biomechanics2020013},
  pages     = {138 -- 157},
  year      = {2022},
  abstract  = {The objective of this paper is to present our findings on the biomechanical aspects of the virgin passive anisotropic hyperelasticity of the porcine colon based on equibiaxial tensile experiments. Firstly, the characterization of the intestine tissues is discussed for a nearly incompressible hyperelastic fiber-reinforced Holzapfel-Gasser-Ogden constitutive model in virgin passive loading conditions. The stability of the evaluated material parameters is checked for the polyconvexity of the adopted strain energy function using positive eigenvalue constraints of the Hessian matrix with MATLAB. The constitutive material description of the intestine with two collagen fibers in the submucosal and muscular layer each has been implemented in the FORTRAN platform of the commercial finite element software LS-DYNA, and two equibiaxial tensile simulations are presented to validate the results with the optical strain images obtained from the experiments. Furthermore, this paper also reviews the existing models of the active smooth muscle cells, but these models have not been computationally studied here. The review part shows that the constitutive models originally developed for the active contraction of skeletal muscle based on Hill's three-element model, Murphy's four-state cross-bridge chemical kinetic model and Huxley's sliding-filament hypothesis, which are mainly used for arteries, are appropriate for numerical contraction numerical analysis of the large intestine.},
  language  = {en}
}
@article{BertzSchoeningMolinnusetal.2024,
  author    = {Bertz, Morten and Sch{\"o}ning, Michael Josef and Molinnus, Denise and Homma, Takayuki},
  title     = {Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping},
  series = {Physica status solidi (a) applications and materials science},
  journal   = {Physica status solidi (a) applications and materials science},
  number    = {Early View},
  publisher = {Wiley-VCH},
  address   = {Berlin},
  issn      = {1862-6319 (Online)},
  doi       = {10.1002/pssa.202300866},
  pages     = {8 Seiten},
  year      = {2024},
  abstract  = {To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30\% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem.},
  language  = {en}
}
@article{BertzMolinnusSchoeningetal.2023,
  author    = {Bertz, Morten and Molinnus, Denise and Sch{\"o}ning, Michael Josef and Homma, Takayuki},
  title     = {Real-time monitoring of H₂O₂ sterilization on individual bacillus atrophaeus spores by optical sensing with trapping Raman spectroscopy},
  series = {Chemosensors},
  volume    = {8},
  journal   = {Chemosensors},
  number    = {11},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors11080445},
  pages     = {Artikel 445},
  year      = {2023},
  abstract  = {Hydrogen peroxide (H₂O₂), a strong oxidizer, is a commonly used sterilization agent employed during aseptic food processing and medical applications. To assess the sterilization efficiency with H₂O₂, bacterial spores are common microbial systems due to their remarkable robustness against a wide variety of decontamination strategies. Despite their widespread use, there is, however, only little information about the detailed time-resolved mechanism underlying the oxidative spore death by H₂O₂. In this work, we investigate chemical and morphological changes of individual Bacillus atrophaeus spores undergoing oxidative damage using optical sensing with trapping Raman microscopy in real-time. The time-resolved experiments reveal that spore death involves two distinct phases: (i) an initial phase dominated by the fast release of dipicolinic acid (DPA), a major spore biomarker, which indicates the rupture of the spore's core; and (ii) the oxidation of the remaining spore material resulting in the subsequent fragmentation of the spores' coat. Simultaneous observation of the spore morphology by optical microscopy corroborates these mechanisms. The dependence of the onset of DPA release and the time constant of spore fragmentation on H₂O₂ shows that the formation of reactive oxygen species from H₂O₂ is the rate-limiting factor of oxidative spore death.},
  language  = {en}
}
@article{BerretzSkorupaSanderetal.2011,
  author    = {Berretz, Frank and Skorupa, Sasche and Sander, Volker and Belloum, Adam and Bubak, Marian},
  title     = {Actor-Driven Workflow Execution in Distributed Environments},
  series = {Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.)},
  journal   = {Euro-Par 2010 Parallel Processing Workshops : HeteroPAR, HPCC, HiBB, CoreGrid, UCHPC, HPCF, PROPER, CCPI, VHPC ; Ischia, Italy, August 31 - September 3, 2010 ; revised selected papers / Mario R. Guarracino ... (eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-642-21877-4},
  pages     = {287 -- 294},
  year      = {2011},
  language  = {en}
}
@article{BerretzSkorupaSanderetal.2010,
  author    = {Berretz, F. and Skorupa, S. and Sander, Volker and Belloum, A.},
  title     = {Towards an actor-driven workflow management system for grids},
  series = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE},
  journal   = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE},
  publisher = {IEEE},
  address   = {Piscataway, NJ},
  isbn      = {978-1-4244-6619-1},
  pages     = {611 -- 616},
  year      = {2010},
  language  = {en}
}
@article{BergmannDemuthSander2011,
  author    = {Bergmann, Sandra and Demuth, Bastian and Sander, Volker},
  title     = {A Web Framework for Workflow Submission and Monitoring via UNICORE 6 based on Distributable Scientific Workflow Templates},
  series = {UNICORE Summit 2011 : proceedings, 7-8 July 2011, Torun, Poland / Mathilde Romberg ... (Eds.)},
  journal   = {UNICORE Summit 2011 : proceedings, 7-8 July 2011, Torun, Poland / Mathilde Romberg ... (Eds.)},
  publisher = {Forschungszentrum J{\"u}lich},
  address   = {J{\"u}lich},
  isbn      = {9783893367504},
  pages     = {45 -- 50},
  year      = {2011},
  language  = {en}
}
@article{BerghoffLanskeSchultzeetal.1988,
  author    = {Berghoff, G. and Lanske, D. and Schultze, K. and Ziemons, Karl},
  title     = {Jets and QCD-effects in muon-nuclean scattering},
  series = {Verhandlungen der Deutschen Physikalischen Gesellschaft},
  volume    = {23},
  journal   = {Verhandlungen der Deutschen Physikalischen Gesellschaft},
  number    = {5},
  isbn      = {0420-0195},
  year      = {1988},
  language  = {en}
}
@article{BelavyAlbrachtBruggemannetal.2016,
  author    = {Belavy, Daniel L. and Albracht, Kirsten and Bruggemann, Gert-Peter and Vergroesen, Pieter-Paul A. and Dieen, Jaap H. van},
  title     = {Can exercise positively influence the intervertebral disc?},
  series = {Sports Medicine},
  volume    = {46},
  journal   = {Sports Medicine},
  number    = {4},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1179-2035},
  doi       = {10.1007/s40279-015-0444-2},
  pages     = {473 -- 485},
  year      = {2016},
  abstract  = {To better understand what kinds of sports and exercise could be beneficial for the intervertebral disc (IVD), we performed a review to synthesise the literature on IVD adaptation with loading and exercise. The state of the literature did not permit a systematic review; therefore, we performed a narrative review. The majority of the available data come from cell or whole-disc loading models and animal exercise models. However, some studies have examined the impact of specific sports on IVD degeneration in humans and acute exercise on disc size. Based on the data available in the literature, loading types that are likely beneficial to the IVD are dynamic, axial, at slow to moderate movement speeds, and of a magnitude experienced in walking and jogging. Static loading, torsional loading, flexion with compression, rapid loading, high-impact loading and explosive tasks are likely detrimental for the IVD. Reduced physical activity and disuse appear to be detrimental for the IVD. We also consider the impact of genetics and the likelihood of a 'critical period' for the effect of exercise in IVD development. The current review summarises the literature to increase awareness amongst exercise, rehabilitation and ergonomic professionals regarding IVD health and provides recommendations on future directions in research.},
  language  = {en}
}
@article{BehnamBeckerWeber2011,
  author    = {Behnam, S. and Becker, A. and Weber, Hans-Joachim},
  title     = {Clinical benefit and cost-efficiency of minimized perfusion circuits for extracorporeal circulation during cardiac surgery},
  series = {Zeitschrift f{\"u}r Herz-, Thorax- und Gef{\"a}ßchirurgie},
  volume    = {25},
  journal   = {Zeitschrift f{\"u}r Herz-, Thorax- und Gef{\"a}ßchirurgie},
  number    = {5},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {0930-9225},
  pages     = {305 -- 306},
  year      = {2011},
  language  = {en}
}
@article{BehbahaniWalugaStocketal.2009,
  author    = {Behbahani, Mehdi and Waluga, C. and Stock, S. and Mai, A. and Bergmann, B. and Behr, M. and Tran, L. and Vonderstein, K. and Scheidt, H. and Oedekoven, B. and Mottaghy, K.},
  title     = {Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth},
  year      = {2009},
  language  = {en}
}
@article{BehbahaniWalugaArltetal.2008,
  author    = {Behbahani, Mehdi and Waluga, C. and Arlt, S. and Behr, M. and Mottaghy, K.},
  title     = {Computational Analysis of Platelet Aggregation in a Taylor-Couette System},
  series = {The International Journal of Artificial Organs. 31 (2008), H. 7},
  journal   = {The International Journal of Artificial Organs. 31 (2008), H. 7},
  isbn      = {0391-3988},
  pages     = {643},
  year      = {2008},
  language  = {en}
}
@article{BehbahaniTranWalugaetal.2009,
  author    = {Behbahani, Mehdi and Tran, L. and Waluga, C. and Behr, M. and Oedekoven, B. and Mottaghy, K.},
  title     = {Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices},
  series = {The International Journal of Artificial Organs. 32 (2009), H. 7},
  journal   = {The International Journal of Artificial Organs. 32 (2009), H. 7},
  isbn      = {0391-3988},
  pages     = {398 -- 398},
  year      = {2009},
  language  = {en}
}
@article{BehbahaniTranJockenhoeveletal.2011,
  author    = {Behbahani, Mehdi and Tran, L. and Jockenh{\"o}vel, S. and Behr, M. and Mottaghy, K.},
  title     = {Numerical prediction of thrombocyte reactions for application to a vascular flow model},
  series = {British Journal of Surgery},
  volume    = {98},
  journal   = {British Journal of Surgery},
  number    = {S5},
  publisher = {Oxford University Press},
  address   = {Oxford},
  isbn      = {1365-2168},
  pages     = {S17},
  year      = {2011},
  language  = {en}
}
@article{BehbahaniSpillnerKoppetal.2009,
  author    = {Behbahani, Mehdi and Spillner, Jan and Kopp, R{\"u}diger and Finocchiaro, Thomas},
  title     = {Assistierte Zirkulation : ein {\"U}berblick aus klinischer Sicht = Assisted circulation: an overview from a clinical perspective / Spillner, Jan ; Kopp, R{\"u}diger ; Finocchiaro, Thomas ; Behbahani, Mehdi ; Rossaint, Rolf ; Steinseifer, Ulrich ; Behr, Marek ; Au},
  series = {Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5},
  journal   = {Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5},
  publisher = {De Gruyter},
  address   = {Berlin},
  isbn      = {0013-5585},
  pages     = {255 -- 267},
  year      = {2009},
  language  = {de}
}
@article{BehbahaniProbstMaietal.2010,
  author    = {Behbahani, Mehdi and Probst, M. and Mai, A. and Tran, L. and Vonderstein, K. and Keschenau, P. and Linde, T. and Steinseifer, U. and Behr, M. and Mottaghy, K.},
  title     = {The influence of high shear on thrombosis and hemolysis in artificial organs},
  series = {Artificial Organs},
  volume    = {33},
  journal   = {Artificial Organs},
  number    = {7},
  isbn      = {0391-3988},
  pages     = {426 -- 426},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniProbstMaietal.2010,
  author    = {Behbahani, Mehdi and Probst, M. and Mai, A. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.},
  title     = {Numerical Prediction of Blood Damage in Biomedical Devices},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniNicolaiProbstetal.2007,
  author    = {Behbahani, Mehdi and Nicolai, M. and Probst, M. and Behr, M.},
  title     = {Simulation of Blood Flow in a Ventricular Assist Device},
  series = {inSIDE. 5 (2007), H. 1},
  journal   = {inSIDE. 5 (2007), H. 1},
  pages     = {28 -- 31},
  year      = {2007},
  language  = {en}
}
@article{BehbahaniNicolai2006,
  author    = {Behbahani, Mehdi and Nicolai, M.},
  title     = {Interaktive Exploration von Blutstr{\"o}mungsprozessen in Herzpumpen},
  series = {VRCA-Jahresbericht 2005/2006},
  journal   = {VRCA-Jahresbericht 2005/2006},
  publisher = {Virtual Reality Center},
  address   = {Aachen},
  pages     = {88 -- 90},
  year      = {2006},
  language  = {de}
}
@article{BehbahaniNamWalugaetal.2010,
  author    = {Behbahani, Mehdi and Nam, J. and Waluga, C. and Behr, M. and Pasquali, M. and Mottaghy, K.},
  title     = {Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs},
  doi       = {10.1097/01.mat.0000369377.65122.a3},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniMaiWalugaetal.2010,
  author    = {Behbahani, Mehdi and Mai, A. and Waluga, C. and Bergmann, B. and Tran, L. and Vonderstein, K. and Behr, M. and Mottaghy, K.},
  title     = {Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions},
  series = {Acta Physiologica},
  volume    = {198},
  journal   = {Acta Physiologica},
  number    = {Supplement 677},
  isbn      = {1748-1716},
  pages     = {185},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniMaiBergmannetal.2010,
  author    = {Behbahani, Mehdi and Mai, A. and Bergmann, B. and Waluga, C. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.},
  title     = {Modeling and Numerical Simulation of Blood Damage},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniFinocchiaroHeinkeetal.2009,
  author    = {Behbahani, Mehdi and Finocchiaro, Thomas and Heinke, Stefanie and Leßmann, Marc},
  title     = {Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung f{\"u}r die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma},
  series = {Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5},
  journal   = {Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5},
  isbn      = {0013-5585},
  pages     = {269 -- 281},
  year      = {2009},
  language  = {en}
}
@article{BehbahaniBehrNicolaietal.2008,
  author    = {Behbahani, Mehdi and Behr, Marek and Nicolai, Mike and Probst, Markus},
  title     = {Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM},
  series = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)},
  journal   = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)},
  publisher = {Forschungszentrum},
  address   = {J{\"u}lich},
  isbn      = {978-3-9810843-5-1},
  pages     = {325 -- 332},
  year      = {2008},
  language  = {en}
}
@article{BehbahaniBehrHormesetal.2009,
  author    = {Behbahani, Mehdi and Behr, M. and Hormes, M. and Steinseifer, U. and Arora, D. and Coronado, O. and Pasquali, M.},
  title     = {A Review of Computational Fluid Dynamics Analysis of Blood Pumps},
  series = {European Journal of Applied Mathematics. 20 (2009), H. 4},
  journal   = {European Journal of Applied Mathematics. 20 (2009), H. 4},
  publisher = {Cambridge Univ. Press},
  address   = {Cambridge},
  pages     = {363 -- 397},
  year      = {2009},
  language  = {en}
}
@article{BehbahaniBehrBischofetal.2007,
  author    = {Behbahani, Mehdi and Behr, M. and Bischof, F. and Wolf, G. E.},
  title     = {Kranken Herzen helfen - Ingenieure und Informatiker entwickeln gemeinsam eine Miniaturblutpumpe / Behbahani, M. ; Behr, M. ; Bischof, F. ; Wolf, G. E.},
  series = {RWTH-Themen (2007)},
  journal   = {RWTH-Themen (2007)},
  isbn      = {0179-079X},
  pages     = {44 -- 46},
  year      = {2007},
  language  = {de}
}
@article{BehbahaniBehrAroraetal.2006,
  author    = {Behbahani, Mehdi and Behr, M. and Arora, D. and Coronado, O. and Pasquali, M.},
  title     = {CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M.},
  series = {Artificial Organs. 30 (2006), H. 11},
  journal   = {Artificial Organs. 30 (2006), H. 11},
  isbn      = {1525-1594},
  pages     = {A45 -- A46},
  year      = {2006},
  language  = {en}
}
@article{BegingPoghossianSchoeningetal.2008,
  author    = {Beging, Stefan and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Hataihimakul, Sudkanung and Busch, H. and Baldsiefen, G. and Laube, N. and Kleinen, L. and Hosseiny, R.},
  title     = {Feldeffektbasierender Ca2+-sensitiver Sensor f{\"u}r den Einsatz im Nativurin zur Bestimmung des Harnsteinbildungsrisikos},
  series = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  journal   = {Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. M{\"a}rz 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-092011-5},
  pages     = {775 -- 782},
  year      = {2008},
  language  = {de}
}
@article{BegingMlynekHataihimakuletal.2010,
  author    = {Beging, Stefan and Mlynek, Daniela and Hataihimakul, Sudkanung and Poghossian, Arshak and Baldsiefen, Gerhard and Busch, Heinz and Laube, Norbert and Kleinen, Lisa and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect calcium sensor for the determination of the risk of urinary stone formation},
  series = {Sensors and Actuators B: Chemical. 144 (2010), H. 2},
  journal   = {Sensors and Actuators B: Chemical. 144 (2010), H. 2},
  pages     = {374 -- 379},
  year      = {2010},
  language  = {en}
}
@article{BegingLeinhosJablonskietal.2015,
  author    = {Beging, Stefan and Leinhos, Marcel and Jablonski, Melanie and Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Studying the spatially resolved immobilisation of enzymes on a capacitive field-effect structure by means of nano-spotting},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431891},
  pages     = {1353 -- 1358},
  year      = {2015},
  language  = {en}
}
@article{BeerStreunHombachetal.2010,
  author    = {Beer, S. and Streun, M. and Hombach, T. and Buehler, J. and Jahnke, S. and Khodaverdi, M. and Larue, H. and Minwuyelet, S. and Parl, C. and Roeb, G. and Schurr, U. and Ziemons, Karl},
  title     = {Design and initial performance of PlanTIS: a high-resolution positron emission tomograph for plants},
  series = {Physics in Medicine and Biology},
  volume    = {55},
  journal   = {Physics in Medicine and Biology},
  number    = {3},
  publisher = {IOP},
  address   = {Bristol},
  issn      = {1361-6560},
  doi       = {10.1088/0031-9155/55/3/006},
  pages     = {635 -- 646},
  year      = {2010},
  abstract  = {Positron emitters such as 11C, 13N and 18F and their labelled compounds are widely used in clinical diagnosis and animal studies, but can also be used to study metabolic and physiological functions in plants dynamically and in vivo. A very particular tracer molecule is 11CO2 since it can be applied to a leaf as a gas. We have developed a Plant Tomographic Imaging System (PlanTIS), a high-resolution PET scanner for plant studies. Detectors, front-end electronics and data acquisition architecture of the scanner are based on the ClearPET™ system. The detectors consist of LSO and LuYAP crystals in phoswich configuration which are coupled to position-sensitive photomultiplier tubes. Signals are continuously sampled by free running ADCs, and data are stored in a list mode format. The detectors are arranged in a horizontal plane to allow the plants to be measured in the natural upright position. Two groups of four detector modules stand face-to-face and rotate around the field-of-view. This special system geometry requires dedicated image reconstruction and normalization procedures. We present the initial performance of the detector system and first phantom and plant measurements.},
  language  = {en}
}
@article{BeckerWallangArtmannetal.2008,
  author    = {Becker, C. and Wallang, C. and Artmann, Gerhard and Jakse, G.},
  title     = {Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis},
  series = {International Journal of Artificial Organs, The},
  volume    = {31},
  journal   = {International Journal of Artificial Organs, The},
  number    = {7},
  issn      = {0391-3988},
  pages     = {583 -- 583},
  year      = {2008},
  language  = {en}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@article{BaumannSchwarzKotliaretal.2009,
  author    = {Baumann, Marcus and Schwarz, Sonja and Kotliar, Konstantin and Eynatten, Maximilian von and Trucksaess, Arno and Burckhardt, Klaus and Lutz, Jens and Heemann, Uwe and Lanzl, Ines},
  title     = {Non-diabetic chronic kidney disease influences retinal microvasculature},
  series = {Kidney and Blood Pressure Research},
  volume    = {32},
  journal   = {Kidney and Blood Pressure Research},
  number    = {6},
  publisher = {-},
  isbn      = {1423-0143},
  pages     = {428 -- 433},
  year      = {2009},
  language  = {en}
}
@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  pages     = {Art. 16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}
@article{BassamDigelHescheleretal.2013,
  author    = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences},
  series = {BMC Biophysics},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  isbn      = {2046-1682},
  url       = {http://nbn-resolving.de/10.1186/2046-1682-6-1},
  pages     = {1 -- 14},
  year      = {2013},
  language  = {en}
}
@article{BassamArtmannHescheleretal.2011,
  author    = {Bassam, Rasha and Artmann, Gerhard and Hescheler, J{\"u}rgen and Graef, T. and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Arinkin, Vladimir and Gossmann, Matthias and Digel, Ilya},
  title     = {Alterations in human hemoglobin structure related to red blood cell storage},
  year      = {2011},
  abstract  = {The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@article{BaroudWuBohneretal.2003,
  author    = {Baroud, G. and Wu, J.Z. and Bohner, M and Sponagel, Stefan and Steffen, T.},
  title     = {How to determine the permeability for cement infiltration into osteoporotic cancellous bone},
  series = {Medical Engineering \& Physics. 25 (2003), H. 4},
  journal   = {Medical Engineering \& Physics. 25 (2003), H. 4},
  issn      = {1350-4533},
  pages     = {283 -- 288},
  year      = {2003},
  abstract  = {Cement augmentation is an emerging surgical procedure in which bone cement is used to infiltrate and reinforce osteoporotic vertebrae. Although this infiltration procedure has been widely applied, it is performed empirically and little is known about the flow characteristics of cement during the injection process. We present a theoretical and experimental approach to investigate the intertrabecular bone permeability during the infiltration procedure. The cement permeability was considered to be dependent on time, bone porosity, and cement viscosity in our analysis. In order to determine the time-dependent permeability, ten cancellous bone cores were harvested from osteoporotic vertebrae, infiltrated with acrylic cement at a constant flow rate, and the pressure drop across the cores during the infiltration was measured. The viscosity dependence of the permeability was determined based on published experimental data. The theoretical model for the permeability as a function of bone porosity and time was then fit to the testing data. Our findings suggest that the intertrabecular bone permeability depends strongly on time. For instance, the initial permeability (60.89 mm4/N.s) reduced to approximately 63\% of its original value within 18 seconds. This study is the first to analyze cement flow through osteoporotic bone. The theoretical and experimental models provided in this paper are generic. Thus, they can be used to systematically study and optimize the infiltration process for clinical practice.},
  subject      = {Osteoporose},
  language  = {en}
}
@article{BaringhausGaigallThiele2018,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel and Thiele, Jan Philipp},
  title     = {Statistical inference for L²-distances to uniformity},
  series = {Computational Statistics},
  volume    = {2018},
  journal   = {Computational Statistics},
  number    = {33},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1613-9658},
  doi       = {10.1007/s00180-018-0820-0},
  pages     = {1863 -- 1896},
  year      = {2018},
  abstract  = {The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study.},
  language  = {en}
}
@article{BaringhausGaigall2022,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {A goodness-of-fit test for the compound Poisson exponential model},
  series = {Journal of Multivariate Analysis},
  volume    = {195},
  journal   = {Journal of Multivariate Analysis},
  number    = {Article 105154},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0047-259X},
  doi       = {10.1016/j.jmva.2022.105154},
  year      = {2022},
  abstract  = {On the basis of bivariate data, assumed to be observations of independent copies of a random vector (S,N), we consider testing the hypothesis that the distribution of (S,N) belongs to the parametric class of distributions that arise with the compound Poisson exponential model. Typically, this model is used in stochastic hydrology, with N as the number of raindays, and S as total rainfall amount during a certain time period, or in actuarial science, with N as the number of losses, and S as total loss expenditure during a certain time period. The compound Poisson exponential model is characterized in the way that a specific transform associated with the distribution of (S,N) satisfies a certain differential equation. Mimicking the function part of this equation by substituting the empirical counterparts of the transform we obtain an expression the weighted integral of the square of which is used as test statistic. We deal with two variants of the latter, one of which being invariant under scale transformations of the S-part by fixed positive constants. Critical values are obtained by using a parametric bootstrap procedure. The asymptotic behavior of the tests is discussed. A simulation study demonstrates the performance of the tests in the finite sample case. The procedure is applied to rainfall data and to an actuarial dataset. A multivariate extension is also discussed.},
  language  = {en}
}
@article{BaringhausGaigall2017,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {Hotelling's T² tests in paired and independent survey samples: An efficiency comparison},
  series = {Journal of Multivariate Analysis},
  volume    = {2017},
  journal   = {Journal of Multivariate Analysis},
  number    = {154},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0047-259X},
  doi       = {10.1016/j.jmva.2016.11.004},
  pages     = {177 -- 198},
  year      = {2017},
  abstract  = {Hotelling's T² tests in paired and independent survey samples are compared using the traditional asymptotic efficiency concepts of Hodges-Lehmann, Bahadur and Pitman, as well as through criteria based on the volumes of corresponding confidence regions. Conditions characterizing the superiority of a procedure are given in terms of population canonical correlation type coefficients. Statistical tests for checking these conditions are developed. Test statistics based on the eigenvalues of a symmetrized sample cross-covariance matrix are suggested, as well as test statistics based on sample canonical correlation type coefficients.},
  language  = {en}
}
@article{BaringhausGaigall2017,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {On Hotelling's T² test in a special paired sample case},
  series = {Communications in Statistics - Theory and Methods},
  volume    = {48},
  journal   = {Communications in Statistics - Theory and Methods},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1532-415X},
  doi       = {10.1080/03610926.2017.1408828},
  pages     = {257 -- 267},
  year      = {2017},
  abstract  = {In a special paired sample case, Hotelling's T² test based on the differences of the paired random vectors is the likelihood ratio test for testing the hypothesis that the paired random vectors have the same mean; with respect to a special group of affine linear transformations it is the uniformly most powerful invariant test for the general alternative of a difference in mean. We present an elementary straightforward proof of this result. The likelihood ratio test for testing the hypothesis that the covariance structure is of the assumed special form is derived and discussed. Applications to real data are given.},
  language  = {en}
}
@article{BaringhausGaigall2019,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {On an asymptotic relative efficiency concept based on expected volumes of confidence regions},
  series = {Statistics - A Journal of Theoretical and Applied Statistic},
  volume    = {53},
  journal   = {Statistics - A Journal of Theoretical and Applied Statistic},
  number    = {6},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1029-4910},
  doi       = {10.1080/02331888.2019.1683560},
  pages     = {1396 -- 1436},
  year      = {2019},
  abstract  = {The paper deals with an asymptotic relative efficiency concept for confidence regions of multidimensional parameters that is based on the expected volumes of the confidence regions. Under standard conditions the asymptotic relative efficiencies of confidence regions are seen to be certain powers of the ratio of the limits of the expected volumes. These limits are explicitly derived for confidence regions associated with certain plugin estimators, likelihood ratio tests and Wald tests. Under regularity conditions, the asymptotic relative efficiency of each of these procedures with respect to each one of its competitors is equal to 1. The results are applied to multivariate normal distributions and multinomial distributions in a fairly general setting.},
  language  = {en}
}
@article{BaringhausGaigall2015,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {On an independence test approach to the goodness-of-fit problem},
  series = {Journal of Multivariate Analysis},
  volume    = {2015},
  journal   = {Journal of Multivariate Analysis},
  number    = {140},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0047-259X},
  doi       = {10.1016/j.jmva.2015.05.013},
  pages     = {193 -- 208},
  year      = {2015},
  abstract  = {Let X₁,…,Xₙ be independent and identically distributed random variables with distribution F. Assuming that there are measurable functions f:R²→R and g:R²→R characterizing a family F of distributions on the Borel sets of R in the way that the random variables f(X₁,X₂),g(X₁,X₂) are independent, if and only if F∈F, we propose to treat the testing problem H:F∈F,K:F∉F by applying a consistent nonparametric independence test to the bivariate sample variables (f(Xᵢ,Xⱼ),g(Xᵢ,Xⱼ)),1⩽i,j⩽n,i≠j. A parametric bootstrap procedure needed to get critical values is shown to work. The consistency of the test is discussed. The power performance of the procedure is compared with that of the classical tests of Kolmogorov-Smirnov and Cram{\´e}r-von Mises in the special cases where F is the family of gamma distributions or the family of inverse Gaussian distributions.},
  language  = {en}
}
@article{BandodkarMolinnusMirzaetal.2014,
  author    = {Bandodkar, Amay J. and Molinnus, Denise and Mirza, Omar and Guinovart, Tomas and Windmiller, Joshua R. and Valdes-Ramirez, Gabriela and Andrade, Francisco J. and Sch{\"o}ning, Michael Josef and Wang, Joseph},
  title     = {Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring},
  series = {Biosensors and bioelectronics},
  volume    = {54},
  journal   = {Biosensors and bioelectronics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-4235 (E-Journal); 0956-5663 (Print)},
  doi       = {10.1016/j.bios.2013.11.039},
  pages     = {603 -- 609},
  year      = {2014},
  abstract  = {This article describes the fabrication, characterization and application of an epidermal temporary-transfer tattoo-based potentiometric sensor, coupled with a miniaturized wearable wireless transceiver, for real-time monitoring of sodium in the human perspiration. Sodium excreted during perspiration is an excellent marker for electrolyte imbalance and provides valuable information regarding an individual's physical and mental wellbeing. The realization of the new skin-worn non-invasive tattoo-like sensing device has been realized by amalgamating several state-of-the-art thick film, laser printing, solid-state potentiometry, fluidics and wireless technologies. The resulting tattoo-based potentiometric sodium sensor displays a rapid near-Nernstian response with negligible carryover effects, and good resiliency against various mechanical deformations experienced by the human epidermis. On-body testing of the tattoo sensor coupled to a wireless transceiver during exercise activity demonstrated its ability to continuously monitor sweat sodium dynamics. The real-time sweat sodium concentration was transmitted wirelessly via a body-worn transceiver from the sodium tattoo sensor to a notebook while the subjects perspired on a stationary cycle. The favorable analytical performance along with the wearable nature of the wireless transceiver makes the new epidermal potentiometric sensing system attractive for continuous monitoring the sodium dynamics in human perspiration during diverse activities relevant to the healthcare, fitness, military, healthcare and skin-care domains.},
  language  = {en}
}
@article{BallVoegeleGrajewskietal.2021,
  author    = {Ball, Christopher Stephen and V{\"o}gele, Stefan and Grajewski, Matthias and Kuckshinrichs, Wilhelm},
  title     = {E-mobility from a multi-actor point of view: Uncertainties and their impacts},
  series = {Technological Forecasting and Social Change},
  volume    = {170},
  journal   = {Technological Forecasting and Social Change},
  number    = {Art. 120925},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {0040-1625},
  doi       = {10.1016/j.techfore.2021.120925},
  year      = {2021},
  language  = {en}
}
@article{BalakirskiKotliarPaulyetal.2018,
  author    = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz},
  title     = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience},
  series = {Dermatologic Surgery},
  journal   = {Dermatologic Surgery},
  number    = {44 (12)},
  publisher = {Wolters Kluwer},
  doi       = {10.1097/DSS.0000000000001615},
  pages     = {1525 -- 1536},
  year      = {2018},
  abstract  = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.},
  language  = {en}
}
@article{AyalaHarrisKleefeldetal.2023,
  author    = {Ayala, Rafael Ceja and Harris, Isaac and Kleefeld, Andreas and Pallikarakis, Nikolaos},
  title     = {Analysis of the transmission eigenvalue problem with two conductivity parameters},
  series = {Applicable Analysis},
  journal   = {Applicable Analysis},
  publisher = {Taylor \& Francis},
  issn      = {0003-6811},
  doi       = {10.1080/00036811.2023.2181167},
  pages     = {37 Seiten},
  year      = {2023},
  abstract  = {In this paper, we provide an analytical study of the transmission eigenvalue problem with two conductivity parameters. We will assume that the underlying physical model is given by the scattering of a plane wave for an isotropic scatterer. In previous studies, this eigenvalue problem was analyzed with one conductive boundary parameter whereas we will consider the case of two parameters. We prove the existence and discreteness of the transmission eigenvalues as well as study the dependence on the physical parameters. We are able to prove monotonicity of the first transmission eigenvalue with respect to the parameters and consider the limiting procedure as the second boundary parameter vanishes. Lastly, we provide extensive numerical experiments to validate the theoretical work.},
  language  = {en}
}
@article{AyalaHarrisKleefeld2024,
  author    = {Ayala, Rafael Ceja and Harris, Isaac and Kleefeld, Andreas},
  title     = {Direct sampling method via Landweber iteration for an absorbing scatterer with a conductive boundary},
  series = {Inverse Problems and Imaging},
  volume    = {18},
  journal   = {Inverse Problems and Imaging},
  number    = {3},
  publisher = {AIMS},
  address   = {Springfield},
  issn      = {1930-8337},
  doi       = {10.3934/ipi.2023051},
  pages     = {708 -- 729},
  year      = {2024},
  abstract  = {In this paper, we consider the inverse shape problem of recovering isotropic scatterers with a conductive boundary condition. Here, we assume that the measured far-field data is known at a fixed wave number. Motivated by recent work, we study a new direct sampling indicator based on the Landweber iteration and the factorization method. Therefore, we prove the connection between these reconstruction methods. The method studied here falls under the category of qualitative reconstruction methods where an imaging function is used to recover the absorbing scatterer. We prove stability of our new imaging function as well as derive a discrepancy principle for recovering the regularization parameter. The theoretical results are verified with numerical examples to show how the reconstruction performs by the new Landweber direct sampling method.},
  language  = {en}
}