@article{OezsoyluKizildagSchoeningetal.2020, author = {{\"O}zsoylu, Dua and Kizildag, Sefa and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS)}, series = {Physics in Medicine}, volume = {10}, journal = {Physics in Medicine}, number = {100030}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-4510}, doi = {10.1016/j.phmed.2020.100030}, pages = {8}, year = {2020}, abstract = {Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images.}, language = {en} } @misc{OPUS4-10313, title = {Dimensionen 1-2020: Magazin der FH Aachen University of Applied Sciences - Bibliotheken im 21. Jahrhundert}, address = {Aachen}, organization = {Fachhochschule Aachen}, pages = {47 Seiten}, year = {2020}, abstract = {04| Wissen stirbt nicht aus 12| Mathe ist sexy! 15| „Bei Gr{\"u}n bitte mit Abstand eintreten" 16| Maschinenbau — mehr als nur Metall 17| Brasilianischer Doktorand der zweiten Generation 18| Aus Alt mach Neu 20| Virtuelle Verleihung 21| Ehrenvolle Auszeichnung 22| Mit Regenjacke und Gummistiefeln 24| Ein Herz aus Beton 27| Wissenstransfer f{\"u}r die Automobilindustrie 28| Mission zum Mond 30| Eine Br{\"u}cke, die sich selbst {\"u}berwacht 32| Licht an — Kanal frei 34| Ein Tropfen auf den heißen Stein 36| Ist ein Studium das Richtige f{\"u}r mich? 38| Himmelblau und Feuerrot 41| Kopfnuss 41| Impressum 42| Mit Leichtigkeit und Transparenz 46| Dialektik des Stillstands}, language = {de} } @misc{OPUS4-10964, title = {Ordnung zur Aufhebung der Pr{\"u}fungsordnung f{\"u}r die Masterstudieng{\"a}nge „Energiewirtschaft \& Informatik" (3 Semester) und „Energiewirtschaft \& Informatik" (4 Semester) vom 4. Mai 2016 (FH-Mitteilung Nr. 59/2016) Fachbereich Energietechnik Fachbereich Medizintechnik und Technomathematik an der Fachhochschule Aachen : vom 16. Januar 2020}, organization = {FH Aachen}, pages = {3 Seiten}, year = {2020}, language = {de} } @misc{OPUS4-10965, title = {Verwaltungs- und Benutzungsordnung des Solar-Instituts J{\"u}lich (SIJ) : vom 27. Januar 2020}, organization = {FH Aachen}, pages = {5 Seiten}, year = {2020}, language = {de} } @misc{OPUS4-10966, title = {Verwaltungs- und Benutzungsordnung des Solar-Instituts J{\"u}lich (SIJ) vom 27. Januar 2020 : berichtigt durch Bekanntmachung vom 18. M{\"a}rz 2020 (FH-Mitteilung Nr. 27/2020)}, organization = {FH Aachen}, pages = {5 Seiten}, year = {2020}, language = {de} }