@article{Hillen1980, author = {Hillen, Walter}, title = {RHO-RHO production by two photon scattering. TASSO Collaboration}, series = {Physics Letters B. 97 (1980), H. 3-4}, journal = {Physics Letters B. 97 (1980), H. 3-4}, isbn = {0370-2693}, pages = {448 -- 452}, year = {1980}, language = {en} } @article{Hillen1979, author = {Hillen, Walter}, title = {Energy scan for narrow states in e+e\&\#8722; annihilation at C.M. energies between 29.90 and 31.46 GeV. TASSO Collaboration}, series = {Physics Letters B. 88 (1979), H. 1-2}, journal = {Physics Letters B. 88 (1979), H. 1-2}, isbn = {0370-2693}, pages = {199 -- 202}, year = {1979}, language = {en} } @article{Hillen1979, author = {Hillen, Walter}, title = {Properties of hadron final states in e+e\&\#8722; annihilation at 13 GeV and 17 GeV center of mass energies. TASSO Collaboration}, series = {Physics Letters B. 83 (1979), H. 2}, journal = {Physics Letters B. 83 (1979), H. 2}, isbn = {0370-2693}, pages = {261 -- 266}, year = {1979}, language = {en} } @article{HillenAlperSelverFischeretal.2007, author = {Hillen, Walter and Alper Selver, M. and Fischer, Felix and Kuntalp, Mehmet}, title = {A software tool for interactive generation, representation, and systematical storage of transfer functions for 3D medical images / Alper Selver, M. ; Fischer, Felix ; Kuntalp, Mehmet ; Hillen, Walter}, series = {Computer Methods and Programs in Biomedicine. 86 (2007), H. 3}, journal = {Computer Methods and Programs in Biomedicine. 86 (2007), H. 3}, publisher = {-}, isbn = {0169-2607}, pages = {270 -- 280}, year = {2007}, language = {en} } @article{HillenBarryPongs1997, author = {Hillen, Walter and Barry, J. C. and Pongs, U. M.}, title = {Algorithm for Purkinje Image I and IV and Limbus Centre Location. Barry, J. C.; Pongs, U. M.; Hillen, W.}, series = {Computers in Biology and Medicine. 27 (1997), H. 6}, journal = {Computers in Biology and Medicine. 27 (1997), H. 6}, isbn = {0010-4825}, pages = {515 -- 531}, year = {1997}, language = {en} } @article{HillenEckenbachQuadfliegetal.1991, author = {Hillen, Walter and Eckenbach, W. and Quadflieg, Peter and Zaengel, Thomas T.}, title = {Signal-to-noise performance of a CsI fluorescent screen}, series = {Medical Imaging V: Image physics}, journal = {Medical Imaging V: Image physics}, isbn = {0-8194-0538-8}, pages = {120 -- 131}, year = {1991}, language = {en} } @article{HillenFischer2004, author = {Hillen, Walter and Fischer, Felix}, title = {Farbanalyse von gebackenen oder frittierten Nahrungsmitteln und Vorhersage des Acrylamid-Wertes}, series = {10. Workshop Farbbildverarbeitung : Elektronische Ressource : 7.-8. Oktober 2004, Koblenz = 10th Workshop Color Image Processing / Detlev Droege ... Hrsg.}, journal = {10. Workshop Farbbildverarbeitung : Elektronische Ressource : 7.-8. Oktober 2004, Koblenz = 10th Workshop Color Image Processing / Detlev Droege ... Hrsg.}, publisher = {Der Andere Verl.}, address = {T{\"o}nning [u.a.]}, isbn = {389959245X}, pages = {133 -- 148}, year = {2004}, language = {de} } @article{HillenFischerPaulus2007, author = {Hillen, Walter and Fischer, Felix and Paulus, Dietrich}, title = {3D Presentation States: Parametrisierung und Speicherung der 3D-Darstellung von segmentierten medizinischen Volumendaten / Fischer, Felix ; Hillen, Walter ; Paulus, Dietrich}, series = {Biomedizinische Technik. 52 (2007), H. Erg{\"a}nzungsband}, journal = {Biomedizinische Technik. 52 (2007), H. Erg{\"a}nzungsband}, isbn = {0939-4990}, pages = {1 -- 2}, year = {2007}, language = {de} } @article{HillenJansenUnglaubenetal.1998, author = {Hillen, Walter and Jansen, N. and Unglauben, F. and Indefrey, R.}, title = {Multimediale Darstellung und Verarbeitung medizinischer Bilddaten in Rechnernetzen.}, series = {Bildverarbeitung f{\"u}r die Medizin 1998 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops am 26. und 27. M{\"a}rz 1998 in Aachen / Thomas Lehmann ... (Hrsg.)}, journal = {Bildverarbeitung f{\"u}r die Medizin 1998 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops am 26. und 27. M{\"a}rz 1998 in Aachen / Thomas Lehmann ... (Hrsg.)}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3540638857}, pages = {373 -- 377}, year = {1998}, language = {de} } @article{HillenLehmannHornetal.1996, author = {Hillen, Walter and Lehmann, T. and Horn, H. and Schmitt, W.}, title = {IDEFIX - Identifizierung dentaler Fixturen mit morphologischen Filtern. Lehmann, T.; Horn, H.; Schmitt, W., Hillen, W.; Spitzer, K.}, series = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen ; proceedings des Aachener Workshops am 8. und 9. November 1996 / Institut f{\"u}r Medizinische Informatik und Biometrie der RWTH Aachen. Hrsg. von Thomas Lehmann ...}, journal = {Bildverarbeitung f{\"u}r die Medizin : Algorithmen - Systeme - Anwendungen ; proceedings des Aachener Workshops am 8. und 9. November 1996 / Institut f{\"u}r Medizinische Informatik und Biometrie der RWTH Aachen. Hrsg. von Thomas Lehmann ...}, publisher = {Verl. der Augustinus-Buchh.}, address = {Aachen}, isbn = {3-86073-519-5}, pages = {327 -- 332}, year = {1996}, language = {de} } @article{HillenLehmannHornetal.1996, author = {Hillen, Walter and Lehmann, T. and Horn, H. and Schmitt, W.}, title = {Identification of Dental Fixtures in Intraoral X-rays. Lehmann, T.; Hillen, W.; Horn, H.; Schmitt, W.}, series = {Medical imaging 1996 : image processing ; 12 - 15 February 1996, Newport Beach, California / Murray H. Loew ... chairs/ed.}, journal = {Medical imaging 1996 : image processing ; 12 - 15 February 1996, Newport Beach, California / Murray H. Loew ... chairs/ed.}, publisher = {SPIE - The International Society for Optical Engineering}, address = {Bellingham, Wash.}, isbn = {0-8194-2085-9}, pages = {584 -- 584}, year = {1996}, language = {en} } @article{HillenLehmannHornetal.1995, author = {Hillen, Walter and Lehmann, T. and Horn, H. and Schmitt, W.}, title = {IDEFIX - Identification of Dental Fixtures. Lehmann, T.; Hillen, W.; Horn, H.; Schmitt, W.}, series = {5th European Congress on Dental and Maxillo-Facial Radiology : 30th Annual meeting of Working Group for Dental Radiology in the German Scientific Society for Dentistry, November 8-11, 1995, Cologne : abstracts}, journal = {5th European Congress on Dental and Maxillo-Facial Radiology : 30th Annual meeting of Working Group for Dental Radiology in the German Scientific Society for Dentistry, November 8-11, 1995, Cologne : abstracts}, pages = {[120] B. : graph. Darst.}, year = {1995}, language = {en} } @article{HillenRuppSchiebeletal.1989, author = {Hillen, Walter and Rupp, S. and Schiebel, U. and Zaengel, Thomas T.}, title = {Imaging performance of a selenium-based detector for high-resolution radiography}, series = {Medical Imaging III: Image Formation}, journal = {Medical Imaging III: Image Formation}, isbn = {0-8194-0125-0}, pages = {296}, year = {1989}, language = {en} } @article{HillenSchiebelZaengel1988, author = {Hillen, Walter and Schiebel, U. and Zaengel, T.}, title = {A selenium-based detector for digital slot-radiography}, series = {Medical Imaging II}, journal = {Medical Imaging II}, pages = {253}, year = {1988}, language = {en} } @article{HillenSchiebelZaengel1986, author = {Hillen, Walter and Schiebel, U. and Zaengel, T.}, title = {Image quality in selenium-based digital radiography. Schiebel, U.; Hillen, W.; Zaengel, T.}, series = {Medical Imaging}, journal = {Medical Imaging}, pages = {176}, year = {1986}, language = {en} } @article{HillenSchiebelZaengel1987, author = {Hillen, Walter and Schiebel, U. and Zaengel, T.}, title = {Imaging performance of a digital storage phosphor system}, series = {Medical Physics. 14 (1987), H. 5}, journal = {Medical Physics. 14 (1987), H. 5}, isbn = {0094-2405}, pages = {744 -- 751}, year = {1987}, language = {en} } @article{HillenSchmittBockemuehl1995, author = {Hillen, Walter and Schmitt, W. and Bockem{\"u}hl, J.}, title = {Signal-to-Noise Performance of a digital dental X-ray Detector}, series = {Computer assisted radiology : proceedings of the International Symposium on Computer and Communication Systems for Image Guided Diagnosis and Therapy / CAR '95 Berlin, June 21 - 24, 1995. Ed. by H. U. Lemke}, journal = {Computer assisted radiology : proceedings of the International Symposium on Computer and Communication Systems for Image Guided Diagnosis and Therapy / CAR '95 Berlin, June 21 - 24, 1995. Ed. by H. U. Lemke}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3-540-59177-X}, pages = {LXXIV, 1442 S. : Ill., graph. Darst.}, year = {1995}, language = {en} } @article{HillenUnglaubenIndefrey2001, author = {Hillen, Walter and Unglauben, F. and Indefrey, F.}, title = {Java Image Viewer zur Darstellung und Verarbeitung medizinischer Bilddaten in Rechnernetzen}, series = {Intelligente, innovative Produktentwicklung f{\"u}r die industrielle Praxis. Stenzel, Horst [Hrsg.]}, journal = {Intelligente, innovative Produktentwicklung f{\"u}r die industrielle Praxis. Stenzel, Horst [Hrsg.]}, publisher = {Forschungverbund Multimedia an Fachhochschulen}, address = {K{\"o}ln}, pages = {23 -- 28}, year = {2001}, language = {de} } @article{HillenUnglaubenKondring2001, author = {Hillen, Walter and Unglauben, F. and Kondring, T.}, title = {Java DICOM Viewer f{\"u}r die Teleradiologie. Unglauben, F.; Hillen, W.; Kondring, T.}, series = {Bildverarbeitung f{\"u}r die Medizin 2001 : Algorithmen, Systeme, Anwendungen ; proceedings des Workshops [Bildverarbeitung f{\"u}r die Medizin] vom 4. - 6. M{\"a}rz 2001 in L{\"u}beck / Heinz Handels ... [Hrsg.]}, journal = {Bildverarbeitung f{\"u}r die Medizin 2001 : Algorithmen, Systeme, Anwendungen ; proceedings des Workshops [Bildverarbeitung f{\"u}r die Medizin] vom 4. - 6. M{\"a}rz 2001 in L{\"u}beck / Heinz Handels ... [Hrsg.]}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3-540-41690-0}, pages = {404 -- 408}, year = {2001}, language = {de} } @article{HillenUnglaubenMurdfield2001, author = {Hillen, Walter and Unglauben, F. and Murdfield, M.}, title = {Study of Database Connections for a Java Medical Image Viewer. Unglauben, F.; Hillen, W.; Murdfield, M.}, series = {Intelligente, innovative Produktentwicklung f{\"u}r die industrielle Praxis. Bl{\"u}mel, Bernd; Stenzel, Horst [Hrsg.]}, journal = {Intelligente, innovative Produktentwicklung f{\"u}r die industrielle Praxis. Bl{\"u}mel, Bernd; Stenzel, Horst [Hrsg.]}, publisher = {Forschungverbund Multimedia an Fachhochschulen}, address = {K{\"o}ln}, pages = {29 -- 33}, year = {2001}, language = {en} } @article{HillenUnglaubenMurdfield2000, author = {Hillen, Walter and Unglauben, F. and Murdfield, M.}, title = {Evaluation of two- and three-tier database connections for a java-based medical image viewer. Unglauben, F.; Hillen, W.; Murdfield, M.}, series = {Bildverarbeitung f{\"u}r die Medizin 2000 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops [Bildverarbeitung f{\"u}r die Medizin] vom 12. - 14. M{\"a}rz 2000 in M{\"u}nchen / Alexander Horsch ... [Hrsg.]}, journal = {Bildverarbeitung f{\"u}r die Medizin 2000 : Algorithmen - Systeme - Anwendungen ; proceedings des Workshops [Bildverarbeitung f{\"u}r die Medizin] vom 12. - 14. M{\"a}rz 2000 in M{\"u}nchen / Alexander Horsch ... [Hrsg.]}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3-540-67123-4}, pages = {203 -- 207}, year = {2000}, language = {de} } @article{HillenUnglaubenWirtz2002, author = {Hillen, Walter and Unglauben, F. and Wirtz, G.}, title = {Architectures and Modeling of Distributed Image Information Systems. Unglauben, F.; Hillen, W.; Wirtz, G.}, series = {Proceedings : July 14 - 18, 2002, Orlando, Florida, USA ; [jointly with the 8th International Conference on Information Systems Analysis and Synthesis (ISAS 2002)] / organized by IIIS, International Institute of Informatics and Systemics. Ed. by Nagib Callaos}, journal = {Proceedings : July 14 - 18, 2002, Orlando, Florida, USA ; [jointly with the 8th International Conference on Information Systems Analysis and Synthesis (ISAS 2002)] / organized by IIIS, International Institute of Informatics and Systemics. Ed. by Nagib Callaos}, publisher = {IIIS}, address = {Orlando, Fla.}, isbn = {9800781501}, year = {2002}, language = {en} } @article{HillenWinterschladeKrone1998, author = {Hillen, Walter and Winterschlade, T. and Krone, J.}, title = {Erkennung lokaler Bildfehler in R{\"o}ntgenbildverst{\"a}rkern durch parallel arbeitende Bildrechner}, series = {Parallele Datenverarbeitung : Entwurfsmethoden, Bildverarbeitung, Simulation ; Workshop der Arbeitsgemeinschaft "Parallelverarbeitung an Fachhochschulen in NRW" am 19.6.1998 in Bochum / J{\"o}rg Krone ... (Hrsg.)}, journal = {Parallele Datenverarbeitung : Entwurfsmethoden, Bildverarbeitung, Simulation ; Workshop der Arbeitsgemeinschaft "Parallelverarbeitung an Fachhochschulen in NRW" am 19.6.1998 in Bochum / J{\"o}rg Krone ... (Hrsg.)}, publisher = {VDI-Verl.}, address = {D{\"u}sseldorf}, isbn = {3-18-355310-4}, pages = {88 -- 94}, year = {1998}, language = {de} } @inproceedings{HingleyDikta2019, author = {Hingley, Peter and Dikta, Gerhard}, title = {Finding a well performing box-jenkins forecasting model for annualised patent filings counts}, series = {International Symposium on Forecasting, Thessaloniki, Greece, June 2019}, booktitle = {International Symposium on Forecasting, Thessaloniki, Greece, June 2019}, pages = {24 Folien}, year = {2019}, language = {en} } @article{HirschfeldLustfeldReisseletal.2010, author = {Hirschfeld, J. A. and Lustfeld, H. and Reißel, Martin and Steffen, B.}, title = {A novel scheme for precise diagnostics and effective stabilization of currents in a fuel cell stack}, series = {International Journal of Energy Research. 34 (2010), H. 3}, journal = {International Journal of Energy Research. 34 (2010), H. 3}, isbn = {0363-907X}, pages = {293 -- 301}, year = {2010}, language = {en} } @article{HirschfeldLustfeldReisseletal.2010, author = {Hirschfeld, J. A. and Lustfeld, H. and Reißel, Martin and Steffen, B.}, title = {Tomographic diagnostics of current distributions in a fuel cell stack}, series = {International Journal of Energy Research}, volume = {34}, journal = {International Journal of Energy Research}, number = {3}, isbn = {0363-907X}, pages = {284 -- 292}, year = {2010}, language = {en} } @misc{HofbauerHaertelLoesingetal.1989, author = {Hofbauer, Peter and H{\"a}rtel, G{\"u}nter and L{\"o}sing, Karl-Heinrich and Dorner, Robert and Simonis, Rainer and Schulte, Erasmus}, title = {Brennstoffeinspritzsystem f{\"u}r Brennkraftmaschinen : Offenlegungsschrift DE 3833215 A1 ; Offenlegungstag: 28.12.89}, publisher = {Deutsches Patent- und Markenamt}, address = {M{\"u}nchen}, pages = {12 S.}, year = {1989}, abstract = {Es wird ein Brennstoffeinspritzsystem f{\"u}r Brennkraftmaschinen vorgeschlagen, bei dem ein definiertes Teil eines fest vorgegebenen Brennstoffvolumens durch die Druckerh{\"o}hung innerhalb einer brennstoffeinschließenden Kammer eine definierte Brennstoffmenge {\"u}ber jeweils ein R{\"u}ckschlagventil abgespritzt wird. Ein elektronisches Steuerger{\"a}t berechnet die Dauer und/oder Intensit{\"a}t und gegebenenfalls die Impulsfolge eines zum Beispiel zur Verdampfung einer bestimmten Brennstoffmenge erforderlichen Laserimpulses. Das System kann f{\"u}r Ein- oder Mehrstelleinspritzung Verwendung finden.}, subject = {Brennkraftmaschine}, language = {de} } @article{HonarvarfardGamellaChannaveerappaetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Channaveerappa, Devika and Darie, Costel C. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {Electrochemically Stimulated Insulin Release from a Modified Graphene-functionalized Carbon Fiber Electrode}, series = {Electroanalysis}, volume = {29}, journal = {Electroanalysis}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109}, doi = {10.1002/elan.201700095}, pages = {1543 -- 1553}, year = {2017}, abstract = {A graphene-functionalized carbon fiber electrode was modified with adsorbed polyethylenimine to introduce amino functionalities and then with trigonelline and 4-carboxyphenylboronic acid covalently bound to the amino groups. The trigonelline species containing quarterized pyridine groups produced positive charge on the electrode surface regardless of the pH value, while the phenylboronic acid species were neutral below pH 8 and negatively charged above pH 9 (note that their pKa=8.4). The total charge on the monolayer-modified electrode was positive at the neutral pH and negative at pH > 9. Note that 4-carboxyphenylboronic acid was attached to the electrode surface in molar excess to trigonelline, thus allowing the negative charge to dominate on the electrode surface at basic pH. Negatively charged fluorescent dye-labeled insulin (insulin-FITC) was loaded on the modified electrode surface at pH 7.0 due to its electrostatic attraction to the positively charged interface. The local pH in close vicinity to the electrode surface was increased to ca. 9-10 due to consumption of H+ ions upon electrochemical reduction of oxygen proceeding at the potential of -1.0 V (vs. Ag/AgCl) applied on the modified electrode. The process resulted in recharging of the electrode surface to the negative value due to the formation of the negative charge on the phenylboronic acid groups, thus resulting in the electrostatic repulsion of insulin-FITC and stimulating its release from the electrode surface. The insulin release was characterized by fluorescence spectroscopy (using the FITC-labeled insulin), by electrochemical measurements on an iridium oxide, IrOx, electrode and by mass spectrometry. The graphene-functionalized carbon fiber electrode demonstrated significant advantages in the signal-stimulated insulin release comparing with the carbon fiber electrode without the graphene species.}, language = {en} } @article{HonarvarfardGamellaPoghossianetal.2017, author = {Honarvarfard, Elham and Gamella, Maria and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Katz, Evgeny}, title = {An enzyme-based reversible Controlled NOT (CNOT) logic gate operating on a semiconductor transducer}, series = {Applied Materials Today}, volume = {9}, journal = {Applied Materials Today}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-9407}, doi = {10.1016/j.apmt.2017.08.003}, pages = {266 -- 270}, year = {2017}, abstract = {An enzyme-based biocatalytic system mimicking operation of a logically reversible Controlled NOT (CNOT) gate has been interfaced with semiconductor electronic transducers. Electrolyte-insulator-semiconductor (EIS) structures have been used to transduce chemical changes produced by the enzyme system to an electronically readable capacitive output signal using field-effect features of the EIS device. Two enzymes, urease and esterase, were immobilized on the insulating interface of EIS structure producing local pH changes performing XOR logic operation controlled by various combinations of the input signals represented by urea and ethyl butyrate. Another EIS transducer was functionalized with esterase only, thus performing Identity (ID) logic operation for the ethyl butyrate input. Both semiconductor devices assembled in parallel operated as a logically reversible CNOT gate. The present system, despite its simplicity, demonstrated for the first time logically reversible function of the enzyme system transduced electronically with the semiconductor devices. The biomolecular realization of a CNOT gate interfaced with semiconductors is promising for integration into complex biomolecular networks and future biosensor/biomedical applications.}, language = {en} } @article{HorbachDuongStaat2017, author = {Horbach, Andreas and Duong, Minh Tuan and Staat, Manfred}, title = {Modelling of compressible and orthotropic surgical mesh implants based on optical deformation measurement}, series = {Journal of the mechanical behavior of biomedical materials}, volume = {74}, journal = {Journal of the mechanical behavior of biomedical materials}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1751-6161}, doi = {10.1016/j.jmbbm.2017.06.012}, pages = {400 -- 410}, year = {2017}, language = {en} } @article{HorbachStaat2018, author = {Horbach, Andreas and Staat, Manfred}, title = {Optical strain measurement for the modeling of surgical meshes and their porosity}, series = {Current Directions in Biomedical Engineering}, volume = {Band 4}, journal = {Current Directions in Biomedical Engineering}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {2364-5504}, doi = {10.1515/cdbme-2018-0045}, pages = {181 -- 184}, year = {2018}, abstract = {The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.}, language = {en} } @article{HorbachStaatPerezVianaetal.2020, author = {Horbach, Andreas and Staat, Manfred and Perez-Viana, Daniel and Simmen, Hans-Peter and Neuhaus, Valentin and Pape, Hans-Christoph and Prescher, Andreas and Ciritsis, Bernhard}, title = {Biomechanical in vitro examination of a standardized low-volume tubular femoroplasty}, series = {Clinical Biomechanics}, volume = {80}, journal = {Clinical Biomechanics}, number = {Art. 105104}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.clinbiomech.2020.105104}, year = {2020}, abstract = {Background Osteoporosis is associated with the risk of fractures near the hip. Age and comorbidities increase the perioperative risk. Due to the ageing population, fracture of the proximal femur also proves to be a socio-economic problem. Preventive surgical measures have hardly been used so far. Methods 10 pairs of human femora from fresh cadavers were divided into control and low-volume femoroplasty groups and subjected to a Hayes fall-loading fracture test. The results of the respective localization and classification of the fracture site, the Singh index determined by computed tomography (CT) examination and the parameters in terms of fracture force, work to fracture and stiffness were evaluated statistically and with the finite element method. In addition, a finite element parametric study with different position angles and variants of the tubular geometry of the femoroplasty was performed. Findings Compared to the control group, the work to fracture could be increased by 33.2\%. The fracture force increased by 19.9\%. The used technique and instrumentation proved to be standardized and reproducible with an average poly(methyl methacrylate) volume of 10.5 ml. The parametric study showed the best results for the selected angle and geometry. Interpretation The cadaver studies demonstrated the biomechanical efficacy of the low-volume tubular femoroplasty. The numerical calculations confirmed the optimal choice of positioning as well as the inner and outer diameter of the tube in this setting. The standardized minimally invasive technique with the instruments developed for it could be used in further comparative studies to confirm the measured biomechanical results.}, language = {en} } @article{HorstmannBialonskiNoenningetal.2010, author = {Horstmann, Marie-Therese and Bialonski, Stephan and Noenning, Nina and Mai, Heinke and Prusseit, Jens and Wellmer, J{\"o}rg and Hinrichs, Hermann and Lehnertz, Klaus}, title = {State dependent properties of epileptic brain networks: Comparative graph-theoretical analyses of simultaneously recorded EEG and MEG}, series = {Clinical Neurophysiology}, volume = {121}, journal = {Clinical Neurophysiology}, number = {2}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1388-2457}, doi = {10.1016/j.clinph.2009.10.013}, pages = {172 -- 185}, year = {2010}, abstract = {Objective To investigate whether functional brain networks of epilepsy patients treated with antiepileptic medication differ from networks of healthy controls even during the seizure-free interval. Methods We applied different rules to construct binary and weighted networks from EEG and MEG data recorded under a resting-state eyes-open and eyes-closed condition from 21 epilepsy patients and 23 healthy controls. The average shortest path length and the clustering coefficient served as global statistical network characteristics. Results Independent on the behavioral condition, epileptic brains exhibited a more regular functional network structure. Similarly, the eyes-closed condition was characterized by a more regular functional network structure in both groups. The amount of network reorganization due to behavioral state changes was similar in both groups. Consistent findings could be achieved for networks derived from EEG but hardly from MEG recordings, and network construction rules had a rather strong impact on our findings. Conclusions Despite the locality of the investigated processes epileptic brain networks differ in their global characteristics from non-epileptic brain networks. Further methodological developments are necessary to improve the characterization of disturbed and normal functional networks. Significance An increased regularity and a diminished modulation capability appear characteristic of epileptic brain networks.}, language = {en} } @inproceedings{HuckBaeckerPoghossianetal.2011, author = {Huck, Christina and B{\"a}cker, Matthias and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Bifunktionaler Sensorchip f{\"u}r den Nachweis von Gel{\"o}stwasserstoff}, isbn = {978-3942710-53-4}, doi = {10.5162/10dss2011/16.10}, pages = {325 -- 328}, year = {2011}, language = {de} } @article{HuckJollyWagneretal.2011, author = {Huck, Christina and Jolly, Christina and Wagner, Patrick and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen}, series = {Procedia Engineering. 25 (2011)}, journal = {Procedia Engineering. 25 (2011)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1877-7058}, pages = {1161 -- 1164}, year = {2011}, language = {en} } @inproceedings{HuckPoghossianBuniatyanetal.2014, author = {Huck, Christina and Poghossian, Arshak and Buniatyan, V. and Sch{\"o}ning, Michael Josef}, title = {Multi-parameter detection for supporting monitoring and control of biogas processes in agriculture}, series = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, booktitle = {Sensoren und Messsysteme 2014 ; Beitr{\"a}ge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in N{\"u}rnberg. (ITG-Fachbericht ; 250)}, publisher = {VDE-Verl.}, address = {Berlin}, organization = {VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik}, isbn = {978-3-8007-3622-5}, pages = {1 -- 5}, year = {2014}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Chaudhuri, S. and Zander, W. and Schubert, J. and Begoyan, V. K. and Buniatyan, V. V. and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {Capacitively coupled electrolyte-conductivity sensor based on high-k material of barium strontium titanate}, series = {Sensors and actuators. B: Chemical}, journal = {Sensors and actuators. B: Chemical}, number = {198}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3077 (E-Journal); 0925-4005 (Print)}, doi = {10.1016/j.snb.2014.02.103}, pages = {102 -- 109}, year = {2014}, language = {en} } @article{HuckPoghossianBaeckeretal.2015, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Reisert, Steffen and Kramer, Friederike and Begoyan, Vardges K. and Buniatyan, Vahe V. and Sch{\"o}ning, Michael Josef}, title = {Multi-parameter sensing using high-k oxide of barium strontium titanate}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431911}, pages = {1259}, year = {2015}, abstract = {High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors. In this work, a Si-based sensor chip containing Pt interdigitated electrodes covered with a thin BST layer (485 nm) has been developed for multi-parameter chemical sensing. The chip has been applied for the contactless measurement of the electrolyte conductivity, the detection of adsorbed charged macromolecules (positively charged polyelectrolytes of polyethylenimine) and the concentration of hydrogen peroxide (H2O2) vapor. The experimental results of functional testing of individual sensors are presented. The mechanism of the BST sensitivity to charged polyelectrolytes and H2O2 vapor has been proposed and discussed.}, language = {en} } @article{HuckPoghossianBaeckeretal.2014, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Reisert, Steffen and Schubert, J. and Zander, W. and Begoyan, V. K. and Buniatyan, V. V. and Sch{\"o}ning, Michael Josef}, title = {Chemical sensors based on a high-k perovskite oxide of barium strontium titanate}, series = {Procedia Engineering}, volume = {87}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2014.11.258}, pages = {28 -- 31}, year = {2014}, abstract = {High-k perovskite oxide of barium strontium titanate (BST) represents a very attractive multi-functional transducer material for the development of (bio-)chemical sensors for liquids. In this work, BST films have been applied as a sensitive transducer material for a label-free detection of adsorbed charged macromolecules (positively charged polyelectrolytes) and concentration of hydrogen peroxide vapor as well as protection insulator layer for a contactless electrolyte-conductivity sensor. The experimental results of characterization of individual sensors are presented. Special emphasis is devoted towards the development of a capacitively-coupled contactless electrolyte-conductivity sensor.}, language = {en} } @inproceedings{HuckPoghossianBaeckeretal.2013, author = {Huck, Christina and Poghossian, Arshak and B{\"a}cker, Matthias and Zander, W. and Schubert, J. and Sukoyan, L. H. and Begoyan, V. and Buniatyan, V. V. and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Chemische Sensoren mit Bariumstrontiumtitanat als funktionelle Schicht zur Multiparameterdetektion}, series = {11. Dresdner Sensor-Symposium : 9.-11.12.2013}, booktitle = {11. Dresdner Sensor-Symposium : 9.-11.12.2013}, organization = {Dresdner Sensor-Symposium <11, 2013>}, isbn = {978-3-9813484-5-3}, pages = {368 -- 372}, year = {2013}, language = {de} } @article{HuckPoghossianKerroumietal.2014, author = {Huck, Christina and Poghossian, Arshak and Kerroumi, Iman and Schusser, Sebastian and B{\"a}cker, Matthias and Zander, Willi and Schubert, J{\"u}rgen and Buniatyan, Vahe V. and Martirosyan, Norayr W. and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Multiparameter sensor chip with Barium Strontium Titanate as multipurpose material}, series = {Electroanalysis}, volume = {26}, journal = {Electroanalysis}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-4109 (E-Journal); 1040-0397 (Print)}, doi = {10.1002/elan.201400076}, pages = {980 -- 987}, year = {2014}, abstract = {It is well known that biochemical and biotechnological processes are strongly dependent and affected by a variety of physico-chemical parameters such as pH value, temperature, pressure and electrolyte conductivity. Therefore, these quantities have to be monitored or controlled in order to guarantee a stable process operation, optimization and high yield. In this work, a sensor chip for the multiparameter detection of three physico-chemical parameters such as electrolyte conductivity, pH and temperature is realized using barium strontium titanate (BST) as multipurpose material. The chip integrates a capacitively coupled four-electrode electrolyte-conductivity sensor, a capacitive field-effect pH sensor and a thin-film Pt-temperature sensor. Due to the multifunctional properties of BST, it is utilized as final outermost coating layer of the processed sensor chip and serves as passivation and protection layer as well as pH-sensitive transducer material at the same time. The results of testing of the individual sensors of the developed multiparameter sensor chip are presented. In addition, a quasi-simultaneous multiparameter characterization of the sensor chip in buffer solutions with different pH value and electrolyte conductivity is performed. To study the sensor behavior and the suitability of BST as multifunctional material under harsh environmental conditions, the sensor chip was exemplarily tested in a biogas digestate.}, language = {en} } @article{HuckPoghossianWagneretal.2012, author = {Huck, Christina and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Combined amperometric/field-effect sensor for the detection of dissolved hydrogen}, series = {Sensors and actuators B: Chemical}, volume = {187}, journal = {Sensors and actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2012.10.050}, pages = {168 -- 173}, year = {2012}, abstract = {Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3\% (v/v) with a slope of 198.4 ± 13.7 nA/\% (v/v) and 14.9 ± 0.5 mV/\% (v/v), respectively.}, language = {en} } @article{HuckSchiffelsHerreraetal.2013, author = {Huck, Christina and Schiffels, Johannes and Herrera, Cony N. and Schelden, Maximilian and Selmer, Thorsten and Poghossian, Arshak and Baumann, Marcus and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor}, series = {Physica Status Solidi (A)}, volume = {210}, journal = {Physica Status Solidi (A)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0031-8965}, doi = {10.1002/pssa.201200900}, pages = {926 -- 931}, year = {2013}, abstract = {Living cells are complex biological systems transforming metabolites taken up from the surrounding medium. Monitoring the responses of such cells to certain substrate concentrations is a challenging task and offers possibilities to gain insight into the vitality of a community influenced by the growth environment. Cell-based sensors represent a promising platform for monitoring the metabolic activity and thus, the "welfare" of relevant organisms. In the present study, metabolic responses of the model bacterium Escherichia coli in suspension, layered onto a capacitive field-effect structure, were examined to pulses of glucose in the concentration range between 0.05 and 2 mM. It was found that acidification of the surrounding medium takes place immediately after glucose addition and follows Michaelis-Menten kinetic behavior as a function of the glucose concentration. In future, the presented setup can, therefore, be used to study substrate specificities on the enzymatic level and may as well be used to perform investigations of more complex metabolic responses. Conclusions and perspectives highlighting this system are discussed.}, language = {en} } @article{HugenrothBorchardtRitteretal.2021, author = {Hugenroth, Kristin and Borchardt, Ralf and Ritter, Philine and Groß‑Hardt, Sascha and Meyns, Bart and Verbelen, Tom and Steinseifer, Ulrich and Kaufmann, Tim A. S. and Engelmann, Ulrich M.}, title = {Optimizing cerebral perfusion and hemodynamics during cardiopulmonary bypass through cannula design combining in silico, in vitro and in vivo input}, series = {Scientific Reports}, volume = {11}, journal = {Scientific Reports}, number = {Art. No. 16800}, publisher = {Springer}, address = {Berlin}, issn = {2045-2322}, doi = {10.1038/s41598-021-96397-2}, pages = {1 -- 12}, year = {2021}, abstract = {Cardiopulmonary bypass (CPB) is a standard technique for cardiac surgery, but comes with the risk of severe neurological complications (e.g. stroke) caused by embolisms and/or reduced cerebral perfusion. We report on an aortic cannula prototype design (optiCAN) with helical outflow and jet-splitting dispersion tip that could reduce the risk of embolic events and restores cerebral perfusion to 97.5\% of physiological flow during CPB in vivo, whereas a commercial curved-tip cannula yields 74.6\%. In further in vitro comparison, pressure loss and hemolysis parameters of optiCAN remain unaffected. Results are reproducibly confirmed in silico for an exemplary human aortic anatomy via computational fluid dynamics (CFD) simulations. Based on CFD simulations, we firstly show that optiCAN design improves aortic root washout, which reduces the risk of thromboembolism. Secondly, we identify regions of the aortic intima with increased risk of plaque release by correlating areas of enhanced plaque growth and high wall shear stresses (WSS). From this we propose another easy-to-manufacture cannula design (opti2CAN) that decreases areas burdened by high WSS, while preserving physiological cerebral flow and favorable hemodynamics. With this novel cannula design, we propose a cannulation option to reduce neurological complications and the prevalence of stroke in high-risk patients after CPB.}, language = {en} } @article{HugenrothNeidlinEngelmannetal.2021, author = {Hugenroth, Kristin and Neidlin, Michael and Engelmann, Ulrich M. and Kaufmann, Tim A. S. and Steinseifer, Ulrich and Heilmann, Torsten}, title = {Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk-Reduced Placement: an In Silico Proof-of-Concept}, series = {Artificial Organs}, journal = {Artificial Organs}, number = {Accepted Article}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.13964}, year = {2021}, language = {en} } @inproceedings{HunkerJungGossmannetal.2019, author = {Hunker, Jan and Jung, Alexander and Goßmann, Matthias and Linder, Peter and Staat, Manfred}, title = {Development of a tool to analyze the conduction speed in microelectrode array measurements of cardiac tissue}, series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen}, editor = {Staat, Manfred and Erni, Daniel}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-940402-22-6}, doi = {10.17185/duepublico/48750}, pages = {7 -- 8}, year = {2019}, abstract = {The discovery of human induced pluripotent stem cells reprogrammed from somatic cells [1] and their ability to differentiate into cardiomyocytes (hiPSC-CMs) has provided a robust platform for drug screening [2]. Drug screenings are essential in the development of new components, particularly for evaluating the potential of drugs to induce life-threatening pro-arrhythmias. Between 1988 and 2009, 14 drugs have been removed from the market for this reason [3]. The microelectrode array (MEA) technique is a robust tool for drug screening as it detects the field potentials (FPs) for the entire cell culture. Furthermore, the propagation of the field potential can be examined on an electrode basis. To analyze MEA measurements in detail, we have developed an open-source tool.}, language = {en} } @article{HunkerGossmannRamanetal.2021, author = {Hunker, Jan L. and Gossmann, Matthias and Raman, Aravind Hariharan and Linder, Peter}, title = {Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility}, series = {Journal of Pharmacological and Toxicological Methods}, volume = {111}, journal = {Journal of Pharmacological and Toxicological Methods}, number = {Article number 107044}, publisher = {Elsevier}, address = {New York}, issn = {1056-8719}, doi = {10.1016/j.vascn.2021.107044}, year = {2021}, language = {en} } @article{HuellenkremerGlueckEmonsetal.2000, author = {H{\"u}llenkremer, B. and Gl{\"u}ck, O. and Emons, H. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {Voltohmmetrie an polykristallinen Goldelektroden}, series = {Gesellschaft Mess- und Automatisierungstechnik: Sensoren und Meßsysteme 2000 : Tagung Ludwigsburg, 13. und 14. M{\"a}rz 2000 / VDI/VDE-Gesellschaft Meß- und Automatisierungstechnik}, journal = {Gesellschaft Mess- und Automatisierungstechnik: Sensoren und Meßsysteme 2000 : Tagung Ludwigsburg, 13. und 14. M{\"a}rz 2000 / VDI/VDE-Gesellschaft Meß- und Automatisierungstechnik}, publisher = {VDI-Verl.}, address = {D{\"u}sseldorf:}, isbn = {3-18-091530-7}, pages = {45 -- 54}, year = {2000}, language = {de} } @article{IkenAhlbornGerlachetal.2013, author = {Iken, Heiko and Ahlborn, K. and Gerlach, F. and Vonau, W. and Zander, W. and Schubert, J. and Sch{\"o}ning, Michael Josef}, title = {Development of redox glasses and subsequent processing by means of pulsed laser deposition for realizing silicon-based thin-film sensors}, series = {Electrochimica acta}, journal = {Electrochimica acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1873-3859 (E-Journal); 0013-4686 (Print)}, pages = {Available online 30.8.2013}, year = {2013}, language = {en} } @article{IkenBronderGoretzkietal.2019, author = {Iken, Heiko and Bronder, Thomas and Goretzki, Alexander and Kriesel, Jana and Ahlborn, Kristina and Gerlach, Frank and Vonau, Winfried and Zander, Willi and Schubert, J{\"u}rgen and Sch{\"o}ning, Michael Josef}, title = {Development of a Combined pH- and Redox-Sensitive Bi-Electrode Glass Thin-Film Sensor}, series = {physica status solidi a : applications and materials sciences}, volume = {216}, journal = {physica status solidi a : applications and materials sciences}, number = {12}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201900114}, pages = {1 -- 8}, year = {2019}, language = {en} }