@article{WagnerWernerMiyamotoetal.2009, author = {Wagner, Torsten and Werner, Frederik and Miyamoto, K. and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {A high-density multi-point LAPS set-up using a VCSEL array and FPGA control}, series = {Procedia Chemistry. 1 (2009), H. 1}, journal = {Procedia Chemistry. 1 (2009), H. 1}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1876-6196}, pages = {1483 -- 1486}, year = {2009}, language = {en} } @article{WagnerVornholtWerneretal.2016, author = {Wagner, Torsten and Vornholt, Wolfgang and Werner, Frederik and Yoshinobu, Tatsuo and Miyamoto, Ko-Ichiro and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening}, series = {Physics in medicine}, volume = {2016}, journal = {Physics in medicine}, number = {1}, issn = {2352-4510}, doi = {10.1016/j.phmed.2016.03.001}, pages = {2 -- 7}, year = {2016}, abstract = {The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution.}, language = {en} } @article{WagnerShigiaharaMiyamotoetal.2012, author = {Wagner, Torsten and Shigiahara, N. and Miyamoto, K. and Suzurikawa, J. and Finger, F. and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Light-addressable Potentiometric Sensors and Light-addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility}, series = {Procedia Engineering}, journal = {Procedia Engineering}, number = {47}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2012.09.290}, pages = {890 -- 893}, year = {2012}, abstract = {This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented.}, language = {en} } @article{WagnerSchoeningOttoetal.2004, author = {Wagner, Torsten and Sch{\"o}ning, Michael Josef and Otto, R. and Yoshinobu, T.}, title = {A handheld 16 channel pen-type LAPS as a platform for (bio-)electrochemical sensing}, series = {Biomedizinische Technik. 49 (2004), H. 2}, journal = {Biomedizinische Technik. 49 (2004), H. 2}, isbn = {0932-4666}, pages = {996 -- 997}, year = {2004}, language = {en} } @article{WagnerSchoening2007, author = {Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Light-addressable potentiometric sensors (LAPS): recent trends and applications}, series = {Electrochemical sensor analysis / edited by S. Alegret ...}, journal = {Electrochemical sensor analysis / edited by S. Alegret ...}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-444-53053-0}, pages = {87 -- 128}, year = {2007}, language = {en} } @article{WagnerRaoKloocketal.2006, author = {Wagner, Torsten and Rao, C. and Kloock, Joachim P. and Yoshinobu, T. and Otto, R. and Keusgen, M. and Sch{\"o}ning, Michael Josef}, title = {"LAPS Card"—A novel chip card-based light-addressable potentiometric sensor (LAPS)}, series = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, journal = {Sensors and Actuators B: Chemical. 118 (2006), H. 1-2}, isbn = {0925-4005}, pages = {33 -- 40}, year = {2006}, language = {en} } @article{WagnerMolinaYoshinobuetal.2007, author = {Wagner, Torsten and Molina, Roberto and Yoshinobu, Tatsuo and Kloock, Joachim P. and Biselli, Manfred and Canzoneri, Michele and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef}, title = {Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications}, series = {Electrochimica Acta. 53 (2007), H. 2}, journal = {Electrochimica Acta. 53 (2007), H. 2}, isbn = {0013-4686}, pages = {305 -- 311}, year = {2007}, language = {en} } @article{WagnerMolinaBisellietal.2007, author = {Wagner, Torsten and Molina, R. and Biselli, Manfred and Canzoneri, Michele and Schnitzler, Thomas and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef}, title = {A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells}, series = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)}, journal = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)}, publisher = {IEEE}, address = {Piscataway}, isbn = {1-4244-0841-5}, pages = {1107 -- 1110}, year = {2007}, language = {en} } @article{WagnerMiyamotoShigiharaetal.2011, author = {Wagner, Torsten and Miyamoto, Ko-ichiro and Shigihara, Noriko and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor}, series = {Procedia Engineering. 25 (2011)}, journal = {Procedia Engineering. 25 (2011)}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1877-7058}, pages = {791 -- 794}, year = {2011}, language = {en} } @article{WagnerMiyamotoSchoeningetal.2010, author = {Wagner, Torsten and Miyamoto, Ko-ichiro and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging}, series = {Procedia Engineering. 5 (2010)}, journal = {Procedia Engineering. 5 (2010)}, isbn = {1877-7058}, pages = {520 -- 523}, year = {2010}, language = {en} } @article{WagnerMiyamotoWerneretal.2011, author = {Wagner, Torsten and Miyamoto, K. and Werner, Frederik and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Flexible electrochemical imaging with "zoom-in" functionality by using a new type of light-addressable potentiometric sensor}, publisher = {IEEE}, address = {New York}, pages = {2133 -- 2135}, year = {2011}, language = {en} } @article{WagnerMiyamotoWerneretal.2011, author = {Wagner, Torsten and Miyamoto, K. and Werner, Frederik and Sch{\"o}ning, Michael Josef and Yoshinobu, T.}, title = {Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS)}, volume = {9}, number = {2}, publisher = {American Scientific Publishers}, address = {Stevenson Ranch, Calif.}, doi = {10.1166/sl.2011.1620}, pages = {812 -- 815}, year = {2011}, language = {en} } @article{WagnerMarisAckermannetal.2007, author = {Wagner, Torsten and Maris, Rob J. and Ackermann, Hans-Josef and Otto, Ralph and Beging, Stefan and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations}, series = {Sensors and Actuators B: Chemical . 127 (2007), H. 1}, journal = {Sensors and Actuators B: Chemical . 127 (2007), H. 1}, isbn = {0925-4005}, pages = {217 -- 223}, year = {2007}, language = {en} } @article{WagnerKloockSchoening2007, author = {Wagner, Torsten and Kloock, Joachim P. and Sch{\"o}ning, Michael Josef}, title = {Determination of cadmium concentration and pH value in aqueous solutions by means of a handheld light-addressable potentiometric sensor (LAPS) device}, series = {Electrochemical sensor analysis / edited by S. Alegret ...}, journal = {Electrochemical sensor analysis / edited by S. Alegret ...}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-0-444-53133-9}, pages = {e35 -- e44}, year = {2007}, language = {en} } @article{WagnerDollSchoening2014, author = {Wagner, Patrick and Doll, Theodor and Sch{\"o}ning, Michael Josef}, title = {Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Sch{\"o}ning (eds.)}, series = {Physica status solidi (A) : Applications and materials science}, volume = {211}, journal = {Physica status solidi (A) : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E-Book); 1862-6319 (E-Book); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201470241}, pages = {1339 -- 1339}, year = {2014}, language = {en} } @article{VlasovMourzinaLeginetal.2002, author = {Vlasov, Y. G. and Mourzina, Y. G. and Legin, A. V. and Ermelenko, Y. E. and Schubert, J. and Sch{\"o}ning, Michael Josef and L{\"u}th, H.}, title = {Solid-state thin film sensors based on chalcogenide materials prepared by planar technology and pulsed laser deposition}, series = {Russian Journal of Applied Chemistry. 75 (2002), H. 3}, journal = {Russian Journal of Applied Chemistry. 75 (2002), H. 3}, isbn = {1070-4272}, pages = {351 -- 356}, year = {2002}, language = {en} } @article{VahidpourOberlaenderSchoening2018, author = {Vahidpour, Farnoosh and Oberl{\"a}nder, Jan and Sch{\"o}ning, Michael Josef}, title = {Flexible Calorimetric Gas Sensors for Detection of a Broad Concentration Range of Gaseous Hydrogen Peroxide: A Step Forward to Online Monitoring of Food-Package Sterilization Processes}, series = {Phys. Status Solidi A}, volume = {215}, journal = {Phys. Status Solidi A}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, doi = {10.1002/pssa.201800044}, pages = {Artikel 1800044}, year = {2018}, abstract = {In this study, flexible calorimetric gas sensors are developed for specificdetection of gaseous hydrogen peroxide (H₂O₂) over a wide concentrationrange, which is used in sterilization processes for aseptic packaging industry.The flexibility of these sensors is an advantage for identifying the chemical components of the sterilant on the corners of the food boxes, so-called "coldspots", as critical locations in aseptic packaging, which are of great importance. These sensors are fabricated on flexible polyimide films by means of thin-film technique. Thin layers of titanium and platinum have been deposited on polyimide to define the conductive structures of the sensors. To detect the high-temperature evaporated H₂O₂, a differential temperature set-up is proposed. The sensors are evaluated in a laboratory-scaled sterilizationsystem to simulate the sterilization process. The concentration range of the evaporated H₂O₂ from 0 to 7.7\% v/v was defined and the sensors have successfully detected high as well as low H₂O₂ concentrations with a sensitivity of 5.04 °C/\% v/v. The characterizations of the sensors confirm their precise fabrication, high sensitivity and the novelty of low H₂O₂ concentration detections for future inline monitoring of food-package sterilization.}, language = {en} } @article{VahidpourGuthmanArreolaetal.2022, author = {Vahidpour, Farnoosh and Guthman, Eric and Arreola, Julia and Alghazali, Yousef H. M. and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Assessment of Various Process Parameters for Optimized Sterilization Conditions Using a Multi-Sensing Platform}, series = {Foods}, volume = {11}, journal = {Foods}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2304-8158}, doi = {10.3390/foods11050660}, pages = {Artikel 660}, year = {2022}, abstract = {In this study, an online multi-sensing platform was engineered to simultaneously evaluate various process parameters of food package sterilization using gaseous hydrogen peroxide (H₂O₂). The platform enabled the validation of critical aseptic parameters. In parallel, one series of microbiological count reduction tests was performed using highly resistant spores of B. atrophaeus DSM 675 to act as the reference method for sterility validation. By means of the multi-sensing platform together with microbiological tests, we examined sterilization process parameters to define the most effective conditions with regards to the highest spore kill rate necessary for aseptic packaging. As these parameters are mutually associated, a correlation between different factors was elaborated. The resulting correlation indicated the need for specific conditions regarding the applied H₂O₂ gas temperature, the gas flow and concentration, the relative humidity and the exposure time. Finally, the novel multi-sensing platform together with the mobile electronic readout setup allowed for the online and on-site monitoring of the sterilization process, selecting the best conditions for sterility and, at the same time, reducing the use of the time-consuming and costly microbiological tests that are currently used in the food package industry.}, language = {en} } @article{VahidpourAlghazaliAkcaetal.2022, author = {Vahidpour, Farnoosh and Alghazali, Yousef and Akca, Sevilay and Hommes, Gregor and Sch{\"o}ning, Michael Josef}, title = {An Enzyme-Based Interdigitated Electrode-Type Biosensor for Detecting Low Concentrations of H₂O₂ Vapor/Aerosol}, series = {Chemosensors}, volume = {10}, journal = {Chemosensors}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2227-9040}, doi = {10.3390/chemosensors10060202}, pages = {Arikel 202}, year = {2022}, abstract = {This work introduces a novel method for the detection of H₂O₂ vapor/aerosol of low concentrations, which is mainly applied in the sterilization of equipment in medical industry. Interdigitated electrode (IDE) structures have been fabricated by means of microfabrication techniques. A differential setup of IDEs was prepared, containing an active sensor element (active IDE) and a passive sensor element (passive IDE), where the former was immobilized with an enzymatic membrane of horseradish peroxidase that is selective towards H₂O₂. Changes in the IDEs' capacitance values (active sensor element versus passive sensor element) under H₂O₂ vapor/aerosol atmosphere proved the detection in the concentration range up to 630 ppm with a fast response time (<60 s). The influence of relative humidity was also tested with regard to the sensor signal, showing no cross-sensitivity. The repeatability assessment of the IDE biosensors confirmed their stable capacitive signal in eight subsequent cycles of exposure to H₂O₂ vapor/aerosol. Room-temperature detection of H₂O₂ vapor/aerosol with such miniaturized biosensors will allow a future three-dimensional, flexible mapping of aseptic chambers and help to evaluate sterilization assurance in medical industry.}, language = {en} } @article{TurekKettererClassenetal.2007, author = {Turek, Monika and Ketterer, Lothar and Claßen, Melanie and Berndt, Heinz and Elbers, Gereon and Kr{\"u}ger, Peter and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Development and Electrochemical Investigations of an EIS-(Electrolyte-Insulator-Semiconductor) based Biosensor for Cyanide Detection}, series = {Sensors}, volume = {7}, journal = {Sensors}, number = {8}, isbn = {1424-8220}, pages = {1415 -- 1426}, year = {2007}, language = {en} } @article{TurekHeidenGuoetal.2010, author = {Turek, Monik and Heiden, Wolfgang and Guo, Sharon and Riesen, Alfred and Schubert, J{\"u}rgen and Zander, Willi and Kr{\"u}ger, Peter and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs}, series = {Physica Status Solidi (A). 207 (2010), H. 4}, journal = {Physica Status Solidi (A). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {817 -- 823}, year = {2010}, language = {en} } @article{TurekKeusgenPoghossianetal.2008, author = {Turek, M. and Keusgen, M. and Poghossian, Arshak and Mulchandani, A. and Wang, J. and Sch{\"o}ning, Michael Josef}, title = {Enzyme-modified electrolyte-insulator-semiconductor sensors}, series = {Journal of Contemporary Physics. 43 (2008), H. 2}, journal = {Journal of Contemporary Physics. 43 (2008), H. 2}, isbn = {1934-9378}, pages = {82 -- 85}, year = {2008}, language = {en} } @article{ThustSchoeningFrohnhoffetal.1996, author = {Thust, Marion and Sch{\"o}ning, Michael Josef and Frohnhoff, S. and Arens-Fischer, R. and Kordos, P. and L{\"u}th, H.}, title = {Porous silicon as a substrate material for potentiometric biosensors}, series = {Measurement Science and Technology}, volume = {7}, journal = {Measurement Science and Technology}, number = {1}, doi = {10.1088/0957-0233/7/1/003}, pages = {26 -- 29}, year = {1996}, language = {en} } @article{ThustSchoeningSchrothetal.1999, author = {Thust, M. and Sch{\"o}ning, Michael Josef and Schroth, P. and Malkoc, {\"U}. and Dicker, C. I. and Steffen, A. and Kordos, P. and L{\"u}th, H.}, title = {Enzyme immobilisation on planar and porous silicon substrates for biosensor applications}, series = {Journal of Molecular Catalysis B: Enzymatic. 7 (1999), H. 1-4}, journal = {Journal of Molecular Catalysis B: Enzymatic. 7 (1999), H. 1-4}, isbn = {1381-1177}, pages = {77 -- 83}, year = {1999}, language = {en} } @article{ThustSchrothToepleretal.1998, author = {Thust, M. and Schroth, P. and T{\"o}pler, A. and Sch{\"o}ning, Michael Josef and M{\"u}ller-Veggian, Mattea and Kordos, P. and L{\"u}th, H.}, title = {Improving the detection limit of a capacitive sensor by means of a diffusion barrier}, series = {Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1}, journal = {Eurosensors XII : proceedings of the 12th European Conference on Solid-State Transducers and the 9th UK Conference on Sensors and their Applications, Southampton, UK, 13 - 16 September 1998 / ed. by N. M. White ; Vol. 1}, publisher = {Inst. of Physics Publ.}, address = {Bristol [u.a.]}, isbn = {0-7503-0595-9}, pages = {507 -- 510}, year = {1998}, language = {en} } @article{ThustPoghossianSchoeningetal.1999, author = {Thust, M. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Naser, S. and M{\"u}ller-Veggian, Mattea and Kordos, P. and L{\"u}th, H.}, title = {Crosssensitivity of a capacitive penicillin sensor combined with a diffusion barrier}, series = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.}, journal = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. Vol 1.}, address = {The Hague, The Netherlands}, isbn = {90-76699-02-X}, pages = {573 -- 576}, year = {1999}, language = {en} } @article{ThustPoghossianSchoeningetal.1999, author = {Thust, M. and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Naser, S. and M{\"u}ller-Veggian, Mattea and Kordos, P. and L{\"u}th, H.}, title = {Cross-sensitivity of a capacitive penicillin sensor combined with a diffusion barrier}, series = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1.}, journal = {Proceedings : The Hague, The Netherlands, September 12 - 15, 1999 / [ed. by M. Bartek]. - Vol 1.}, address = {The Hague, The Netherlands}, isbn = {90-76699-02-X}, pages = {573 -- 576}, year = {1999}, language = {en} } @article{TakenagaSchneiderErbayetal.2015, author = {Takenaga, Shoko and Schneider, Benno and Erbay, E. and Biselli, Manfred and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201532053}, pages = {1347 -- 1352}, year = {2015}, abstract = {A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.}, language = {en} } @article{TakenagaBiselliSchnitzleretal.2014, author = {Takenaga, Shoko and Biselli, Manfred and Schnitzler, Thomas and {\"O}hlschl{\"a}ger, Peter and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis-Menten-like kinetics for cell culturing}, series = {Physica status solidi A : Applications and materials science}, volume = {211}, journal = {Physica status solidi A : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330464}, pages = {1410 -- 1415}, year = {2014}, abstract = {The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17-200 mM) follows a Michaelis-Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.}, language = {en} } @article{SpelthahnSchubertSchoening2012, author = {Spelthahn, Heiko and Schubert, J{\"u}rgen and Sch{\"o}ning, Michael Josef}, title = {D{\"u}nnschichtsensoren f{\"u}r die Schwermetallanalytik}, series = {GIT : Labor-Fachzeitschrift}, volume = {56}, journal = {GIT : Labor-Fachzeitschrift}, number = {4}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0016-3538}, pages = {285 -- 287}, year = {2012}, abstract = {Die Detektion von Schadstoffen repr{\"a}sentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte D{\"u}nnschichtsensoren bieten eine kosteng{\"u}nstige M{\"o}glichkeit, „online"-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuf{\"u}hren. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgl{\"a}sern zur Detektion von Schwermetallen in w{\"a}ssrigen Medien vorgestellt.}, language = {en} } @article{SpelthahnSchaffrathCoppeetal.2010, author = {Spelthahn, Heiko and Schaffrath, Sophie and Coppe, Thomas and Rufi, Frederic and Sch{\"o}ning, Michael Josef}, title = {Development of an electrolyte-insulator-semiconductor (EIS) based capacitive heavy metal sensor for the detection of Pb2+ und Cd2+ ions}, series = {Physica status solidi (a) : applications and material science. 207 (2010), H. 4}, journal = {Physica status solidi (a) : applications and material science. 207 (2010), H. 4}, isbn = {1862-6300}, pages = {930 -- 934}, year = {2010}, language = {en} } @article{SpelthahnPoghossianSchoening2009, author = {Spelthahn, Heiko and Poghossian, Arshak and Sch{\"o}ning, Michael Josef}, title = {Self-aligned nanogaps and nanochannels via conventional photolithography and pattern-size reduction technique}, series = {Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI}, journal = {Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI}, isbn = {0013-4686}, pages = {6010 -- 6014}, year = {2009}, language = {en} } @article{SpelthahnKirsanovLeginetal.2012, author = {Spelthahn, Heiko and Kirsanov, Dmitry and Legin, Andrey and Osterrath, Thomas and Schubert, J{\"u}rgen and Zander, Willi and Sch{\"o}ning, Michael Josef}, title = {Development of a thin-film sensor array for analytical monitoring of heavy metals in aqueous solutions}, series = {Physica Status Solidi (a)}, volume = {209}, journal = {Physica Status Solidi (a)}, number = {5}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {1862-6319}, doi = {10.1002/pssa.201100733}, pages = {885 -- 891}, year = {2012}, abstract = {In industrial processes there is a variety of heavy metals (e.g., copper, zinc, cadmium, and lead) in use for wires, coatings, paints, alloys, batteries, etc. Since the application of these transition metals for industry is inevitable, it is a vital task to develop proper analytical techniques for their monitoring at low activity levels, especially because most of these elements are acutely toxic for biological organisms. The determination of ions in solution by means of a simple and inexpensive sensor array is, therefore, a promising task. In this work, a sensor array with heavy metal-sensitive chalcogenide glass membranes for the simultaneous detection of the four ions Ag⁺, Cu2⁺, Cd2⁺, and Pb2⁺ in solution is realized. The results of the physical characterization by means of microscopy, profilometry, Rutherford backscattering spectroscopy (RBS), and scanning electron microscopy (SEM) as well as the electrochemical characterization by means of potentiometric measurements are presented. Additionally, the possibility to expand the sensor array by polymeric sensor membranes is discussed.}, language = {en} } @article{SousaSiqueiraVerciketal.2017, author = {Sousa, Marcos A. M. and Siqueira, Jose R. Jr. and Vercik, Andres and Sch{\"o}ning, Michael Josef and Oliveira, Osvaldo N. Jr.}, title = {Determining the optimized layer-by-layer film architecture with dendrimer/carbon nanotubes for field-effect sensors}, series = {IEEE Sensors Journal}, volume = {17}, journal = {IEEE Sensors Journal}, number = {6}, publisher = {IEEE}, address = {New York}, issn = {1558-1748}, doi = {10.1109/JSEN.2017.2653238}, pages = {1735 -- 1740}, year = {2017}, abstract = {The capacitive electrolyte-insulator-semiconductor (EIS) structure is a typical device based on a field-effect sensor platform. With a simple silicon-based structure, EIS have been useful for several sensing applications, especially with incorporation of nanostructured films to modulate the ionic transport and the flat-band potential. In this paper, we report on ion transport and changes in flat-band potential in EIS sensors made with layer-by-layer films containing poly(amidoamine) (PAMAM) dendrimer and single-walled carbon nanotubes (SWNTs) adsorbed on p-Si/SiO 2 /Ta 2 O 5 chips with an Al ohmic contact. The impedance spectra were fitted using an equivalent circuit model, from which we could determine parameters such as the double-layer capacitance. This capacitance decreased with the number of bilayers owing to space charge accumulated at the electrolyte-insulator interface, up to three PAMAM/SWNTs bilayers, after which it stabilized. The charge-transfer resistance was also minimum for three bilayers, thus indicating that this is the ideal architecture for an optimized EIS performance. The understanding of the influence of nanostructures and the fine control of operation parameters pave the way for optimizing the design and performance of new EIS sensors.}, language = {en} } @article{SiqueiraBaeckerPoghossianetal.2010, author = {Siqueira, Jos{\´e} R. Jr. and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Associating biosensing properties with the morphological structure of multilayers containing carbon nanotubes on field-effect devices}, series = {Physica status solidi (a). 207 (2010), H. 4}, journal = {Physica status solidi (a). 207 (2010), H. 4}, isbn = {1862-6300}, pages = {781 -- 786}, year = {2010}, language = {en} } @article{SiqueiraAbouzarPoghossianetal.2009, author = {Siqueira, Jos{\´e} R. Jr. and Abouzar, Maryam H. and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Penicillin biosensor based on a capacitive field-effect structure functionalized with a dendrimer/carbon nanotube multilayer}, series = {Biosensors and Bioelectronics. 25 (2009), H. 2}, journal = {Biosensors and Bioelectronics. 25 (2009), H. 2}, isbn = {0956-5663}, pages = {497 -- 501}, year = {2009}, language = {en} } @article{SiqueiraAbouzarBaeckeretal.2009, author = {Siqueira, Jos{\´e} R. Jr. and Abouzar, Maryam H. and B{\"a}cker, Matthias and Zucolotto, Valtencir and Poghossian, Arshak and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Carbon nanotubes in nanostructured films: Potential application as amperometric and potentiometric field-effect (bio-)chemical sensors}, series = {physica status solidi (a) . 206 (2009), H. 3}, journal = {physica status solidi (a) . 206 (2009), H. 3}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {462 -- 467}, year = {2009}, language = {en} } @article{SiqueiraWernerBaeckeretal.2009, author = {Siqueira, Jose R. and Werner, Frederik and B{\"a}cker, Matthias and Poghossian, Arshak and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Layer-by-Layer Assembly of Carbon Nanotubes Incorporated in Light-Addressable Potentiometric Sensors}, series = {Journal of Physical Chemistry C. 113 (2009), H. 33}, journal = {Journal of Physical Chemistry C. 113 (2009), H. 33}, publisher = {American Chemical Society}, address = {Washington, DC}, isbn = {1932-7455}, pages = {14765 -- 14770}, year = {2009}, language = {en} } @article{SiqueiraMolinnusBegingetal.2014, author = {Siqueira, Jose R. and Molinnus, Denise and Beging, Stefan and Sch{\"o}ning, Michael Josef}, title = {Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection}, series = {Analytical chemistry}, volume = {86}, journal = {Analytical chemistry}, number = {11}, publisher = {ACS Publications}, address = {Columbus}, issn = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)}, doi = {10.1021/ac500458s}, pages = {5370 -- 5375}, year = {2014}, abstract = {The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor's surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance-voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.}, language = {en} } @article{SiqueiraMakiPaulovichetal.2010, author = {Siqueira, Jose R. and Maki, Rafael M. and Paulovich, Fernando V. and Werner, Frederik and Poghossian, Arshak and Oliveira, Maria C. F. de and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef}, title = {Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor}, series = {Analytical Chemistry (2010)}, journal = {Analytical Chemistry (2010)}, isbn = {0003-2700}, pages = {61 -- 65}, year = {2010}, language = {en} } @article{SimonisRugeMuellerVeggianetal.2003, author = {Simonis, A. and Ruge, C. and M{\"u}ller-Veggian, Mattea and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {A long-term stable macroporoustype EIS structure for electrochemical sensor applications}, series = {Sensors and Actuators B. 91 (2003), H. 1-3}, journal = {Sensors and Actuators B. 91 (2003), H. 1-3}, isbn = {0925-4005}, pages = {21 -- 25}, year = {2003}, language = {en} } @article{SimonisLuethWangetal.2004, author = {Simonis, A. and L{\"u}th, H. and Wang, J. and Sch{\"o}ning, Michael Josef}, title = {New concepts of miniaturised reference electrodes in silicon technology for potentiometric sensor systems}, series = {Sensors and Actuators B. 103 (2004), H. 1-2}, journal = {Sensors and Actuators B. 103 (2004), H. 1-2}, isbn = {0925-4005}, pages = {429 -- 435}, year = {2004}, language = {en} } @article{SimonisLuethWangetal.2003, author = {Simonis, A. and L{\"u}th, H. and Wang, J. and Sch{\"o}ning, Michael Josef}, title = {Strategies of miniaturised reference electrodes integrated in a silicon-based „one chip" pH sensor}, series = {Sensors. 3 (2003), H. 9}, journal = {Sensors. 3 (2003), H. 9}, isbn = {1424-8220}, pages = {330 -- 339}, year = {2003}, language = {en} } @article{SimonisKringsLuethetal.2001, author = {Simonis, A. and Krings, T. and L{\"u}th, H. and Wang, J. and Sch{\"o}ning, Michael Josef}, title = {A „hybrid" thin-film pH sensor with integrated thick-film reference}, series = {Sensors. 1 (2001), H. 6}, journal = {Sensors. 1 (2001), H. 6}, isbn = {1424-8220}, pages = {183 -- 192}, year = {2001}, language = {en} } @article{SimonisDawgulLuethetal.2005, author = {Simonis, A. and Dawgul, M. and L{\"u}th, H. and Sch{\"o}ning, Michael Josef}, title = {Miniaturised reference electrodes for field-effect sensors compatible to silicon chip technology}, series = {Electrochimica Acta. 51 (2005), H. 5}, journal = {Electrochimica Acta. 51 (2005), H. 5}, isbn = {0013-4686}, doi = {10.1016/j.electacta.2005.04.063}, pages = {930 -- 937}, year = {2005}, language = {en} } @article{SchuetzWeissbeckerSchrothetal.2001, author = {Sch{\"u}tz, S. and Weißbecker, G. and Schroth, P. and Sch{\"o}ning, Michael Josef}, title = {Linkage of inanimate structures to biological systems - smart materials in biological micro- nanosystems}, series = {Smart materials : proceedings of the 1st Caesarium, Bonn, November 17 - 19, 1999 / Karl-Heinz Hoffmann ed.}, journal = {Smart materials : proceedings of the 1st Caesarium, Bonn, November 17 - 19, 1999 / Karl-Heinz Hoffmann ed.}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {3-540-67957-X}, pages = {149 -- 157}, year = {2001}, language = {en} } @article{SchuetzWeissbeckerHummeletal.1997, author = {Sch{\"u}tz, S. and Weißbecker, B. and Hummel, Hans E. and Sch{\"o}ning, Michael Josef and Riemer, A. and Kordos, P. and L{\"u}th, H.}, title = {Field effect transistor-insect antenna junction}, series = {Naturwissenschaften}, volume = {84}, journal = {Naturwissenschaften}, issn = {1432-1904}, pages = {86 -- 88}, year = {1997}, language = {en} } @article{SchuetzSchoeningSchrothetal.2000, author = {Sch{\"u}tz, S. and Sch{\"o}ning, Michael Josef and Schroth, P. and Weißbecker, B. and Kordos, P. and L{\"u}th, H. and Hummel, Hans E.}, title = {An insectbased BioFET as a bioelectronic nose}, series = {Sensors and Actuators B. 65 (2000), H. 1-3}, journal = {Sensors and Actuators B. 65 (2000), H. 1-3}, isbn = {0925-4005}, pages = {291 -- 295}, year = {2000}, language = {en} } @article{SchuetzSchoeningSchrothetal.1998, author = {Sch{\"u}tz, S. and Sch{\"o}ning, Michael Josef and Schroth, P. and Weißbecker, B. and Kordos, P. and L{\"u}th, H. and Hummel, Hans E.}, title = {An insectbased BioFET as a bioelectronic nose}, series = {Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou}, journal = {Proceedings of the Seventh International Meeting on Chemical Sensors : 27 - 30 July, 1998, Beijing, P. R. China / ed. Zhi-Gang Zhou}, publisher = {Elsevier}, address = {Amsterdam [u.a.]}, pages = {314 -- 316}, year = {1998}, language = {en} } @article{SchuetzHummelSchoeningetal.1999, author = {Sch{\"u}tz, S. and Hummel, Hans E. and Sch{\"o}ning, Michael Josef and Schroth, P. and Kordos, P. and L{\"u}th, H. and Zimmermann, S. and Schwarz, A. and Kohl, C.-D. and Koczan, D.}, title = {Applications and perspectives of biosensors based on insect olfaction}, series = {Sensor 99 : proceedings / 9th International Fair and Conference for Sensors, Transducers \& Systems, May 18 - 20, 1999, Exhibition Centre N{\"u}rnberg/Germany}, journal = {Sensor 99 : proceedings / 9th International Fair and Conference for Sensors, Transducers \& Systems, May 18 - 20, 1999, Exhibition Centre N{\"u}rnberg/Germany}, publisher = {AMA Service}, address = {Wunstorf}, pages = {99 -- 104}, year = {1999}, language = {en} }