@article{Alt1985, author = {Alt, Helmut}, title = {Multiplikativ oder additiv? Diskussionsbeitrag zu Preisanpassungsklauseln in der Gaswirtschaft}, series = {Energiewirtschaftliche Tagesfragen : et ; Zeitschrift f{\"u}r Energiewirtschaft, Recht, Technik und Umwelt}, volume = {Jg. 35}, journal = {Energiewirtschaftliche Tagesfragen : et ; Zeitschrift f{\"u}r Energiewirtschaft, Recht, Technik und Umwelt}, issn = {0013-743X}, pages = {609 -- 611}, year = {1985}, language = {de} } @article{Alt1986, author = {Alt, Helmut}, title = {Steuersenkungsgesetz-Auswirkungen und Berechnung}, series = {Elektrizit{\"a}tswirtschaft}, volume = {Jg. 85}, journal = {Elektrizit{\"a}tswirtschaft}, issn = {0013-5496}, pages = {238 -- 242}, year = {1986}, language = {de} } @article{Alt1986, author = {Alt, Helmut}, title = {Dialoggesteuerte harmonische Analyse mit dem HP 41}, series = {Elektrizit{\"a}tswirtschaft}, volume = {Bd. 85}, journal = {Elektrizit{\"a}tswirtschaft}, number = {H. 4}, issn = {0013-5496}, pages = {139 -- 142}, year = {1986}, language = {de} } @article{Alt1986, author = {Alt, Helmut}, title = {Dialoggesteuerte harmonische Analyse mit dem HP 41}, series = {Elektrow{\"a}rme international Edition B : Industrielle Elektrow{\"a}rme : IEW = Industrial applications of electro-heat : EWI ; Zeitschr. f{\"u}r das gesamte Gebiet der Elektrow{\"a}rme in Industrie, Gewerbe und Haushalt}, volume = {Jg. 44}, journal = {Elektrow{\"a}rme international Edition B : Industrielle Elektrow{\"a}rme : IEW = Industrial applications of electro-heat : EWI ; Zeitschr. f{\"u}r das gesamte Gebiet der Elektrow{\"a}rme in Industrie, Gewerbe und Haushalt}, number = {H. 6}, issn = {0340-3521}, pages = {283 -- 287}, year = {1986}, language = {de} } @article{Alt1986, author = {Alt, Helmut}, title = {Dialoggesteuerte Spannungs- und Belastungsberechnung im Netz eines Elektrizit{\"a}tsversorgungsunternehmens}, series = {Elektrizit{\"a}tswirtschaft}, volume = {Bd. 85}, journal = {Elektrizit{\"a}tswirtschaft}, number = {H. 23}, issn = {0013-5496}, pages = {906 -- 910}, year = {1986}, language = {de} } @article{Alt1987, author = {Alt, Helmut}, title = {Effektivzinsberechnung bei industriellen oder gewerblichen Tilgungsdarlehen}, series = {Elektrizit{\"a}tswirtschaft}, volume = {Bd. 86}, journal = {Elektrizit{\"a}tswirtschaft}, issn = {0013-5496}, pages = {592 -- 595}, year = {1987}, language = {de} } @article{Alt1989, author = {Alt, Helmut}, title = {Steuerreformgesetz 1990}, series = {Elektrizit{\"a}tswirtschaft}, volume = {Bd. 88}, journal = {Elektrizit{\"a}tswirtschaft}, number = {H. 1/2}, issn = {0013-5496}, pages = {78 -- 83}, year = {1989}, language = {de} } @article{Alt1987, author = {Alt, Helmut}, title = {Steuersenkungs-Erweiterungsgesetz 1988 zur Gesamtentlastung der Einkommensteuer}, series = {Betriebs-Berater : BB ; Zeitschrift f{\"u}r Recht und Wirtschaft}, volume = {Vol. 42}, journal = {Betriebs-Berater : BB ; Zeitschrift f{\"u}r Recht und Wirtschaft}, number = {H. 32}, issn = {0340-7918}, pages = {2207 -- 2208}, year = {1987}, language = {de} } @article{Alt1989, author = {Alt, Helmut}, title = {Steuerreformgesetz 1990}, series = {Elektrizit{\"a}tswirtschaft}, volume = {Jg. 88}, journal = {Elektrizit{\"a}tswirtschaft}, number = {H. 2}, issn = {0947-0581 (E-Journal); 0340-7918 (Print)}, pages = {120 -- 121}, year = {1989}, language = {de} } @article{Alt1990, author = {Alt, Helmut}, title = {Energietarifstruktur in Ostdeutschland}, series = {Energiewirtschaftliche Tagesfragen : et ; Zeitschrift f{\"u}r Energiewirtschaft, Recht, Technik und Umwelt}, volume = {Bd. 40}, journal = {Energiewirtschaftliche Tagesfragen : et ; Zeitschrift f{\"u}r Energiewirtschaft, Recht, Technik und Umwelt}, number = {H. 11}, issn = {0013-743X}, pages = {782 -- 788}, year = {1990}, language = {de} } @article{Alt1991, author = {Alt, Helmut}, title = {Effektivzins und APR}, series = {Die Bank : Zeitschrift f{\"u}r Bankpolitik und Bankpraxis}, volume = {Jg. 31}, journal = {Die Bank : Zeitschrift f{\"u}r Bankpolitik und Bankpraxis}, number = {H. 4}, issn = {0342-3182}, pages = {230 -- 231}, year = {1991}, language = {de} } @article{Alt1992, author = {Alt, Helmut}, title = {M{\"o}glichkeiten der CO2-Minderung "alternativ" betrachtet}, series = {Etz : Elektrotechnik \& Automation}, volume = {Bd. 113}, journal = {Etz : Elektrotechnik \& Automation}, number = {H. 6-7}, issn = {0170-1711}, pages = {400}, year = {1992}, language = {de} } @article{Alt1995, author = {Alt, Helmut}, title = {Netzimpedanz- und Oberschwingungsberechnung in Netzen der {\"o}ffentlichen Stromversorgung}, series = {Elektrizit{\"a}tswirtschaft}, volume = {Bd. 94}, journal = {Elektrizit{\"a}tswirtschaft}, number = {H. 4}, issn = {0013-5496}, pages = {166 -- 174}, year = {1995}, language = {de} } @article{Alt1974, author = {Alt, Helmut}, title = {1,45 Mrd. DM f{\"u}r die Kohlevergasung}, series = {Energiewirtschaftliche Tagesfragen}, volume = {24}, journal = {Energiewirtschaftliche Tagesfragen}, number = {5}, publisher = {VDE-Verlag}, address = {Berlin}, issn = {0720-6240}, pages = {243 -- 244}, year = {1974}, language = {de} } @article{Alt1992, author = {Alt, Helmut}, title = {Renditevergleich zwischen Immobilien und Festverzinslichen}, series = {Die Bank}, journal = {Die Bank}, number = {H. 2}, issn = {0342-3182}, pages = {91 -- 92}, year = {1992}, language = {de} } @article{Alt1975, author = {Alt, Helmut}, title = {Elektro-Brikett-Zentralspeicherheizung soll die Spitzenlast der EVU schonen}, series = {Energiewirtschaftliche Tagesfragen}, volume = {25}, journal = {Energiewirtschaftliche Tagesfragen}, number = {4}, publisher = {VDE-Verlag}, address = {Berlin}, issn = {0720-6240}, pages = {148 -- 149}, year = {1975}, language = {de} } @article{Alt1974, author = {Alt, Helmut}, title = {Ab 1975 Uranerz aus Rabbit-Lake}, series = {Energiewirtschaftliche Tagesfragen}, volume = {24}, journal = {Energiewirtschaftliche Tagesfragen}, number = {1/2}, publisher = {VDE-Verlag}, address = {Berlin}, issn = {0720-6240}, pages = {34}, year = {1974}, language = {de} } @article{AlnemerKotliarNeuhausetal.2023, author = {Alnemer, Momin Sami Mohammad and Kotliar, Konstantin and Neuhaus, Valentin and Pape, Hans-Christoph and Ciritsis, Bernhard D.}, title = {Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model}, series = {Cost Effectiveness and Resource Allocation}, journal = {Cost Effectiveness and Resource Allocation}, number = {21, Article number: 77}, publisher = {Springer Nature}, issn = {1478-7547}, doi = {10.1186/s12962-023-00482-4}, pages = {12 Seiten}, year = {2023}, abstract = {Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare \& Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10\% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10\% fracture risk reduction, model A costs between \$8,850 and \$46,940 per quality-adjusted life-year (\$/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8\% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side's prophylaxis, the patient's age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between \$11,000/QALY and \$74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.}, language = {en} } @article{AlmajhdiSengerAmeretal.2014, author = {Almajhdi, Fahad N. and Senger, Tilo and Amer, Haitham M. and Gissmann, Lutz and {\"O}hlschl{\"a}ger, Peter}, title = {Design of a highly effective therapeutic HPV16 E6/E7-specific DNA vaccine: optimization by different ways of sequence rearrangements (Shuffling)}, series = {PLOS one}, volume = {11}, journal = {PLOS one}, number = {9}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0113461}, pages = {e113461}, year = {2014}, abstract = {Persistent infection with the high-risk Human Papillomavirus type 16 (HPV 16) is the causative event for the development of cervical cancer and other malignant tumors of the anogenital tract and of the head and neck. Despite many attempts to develop therapeutic vaccines no candidate has entered late clinical trials. An interesting approach is a DNA based vaccine encompassing the nucleotide sequence of the E6 and E7 viral oncoproteins. Because both proteins are consistently expressed in HPV infected cells they represent excellent targets for immune therapy. Here we report the development of 8 DNA vaccine candidates consisting of differently rearranged HPV-16 E6 and E7 sequences within one molecule providing all naturally occurring epitopes but supposedly lacking transforming activity. The HPV sequences were fused to the J-domain and the SV40 enhancer in order to increase immune responses. We demonstrate that one out of the 8 vaccine candidates induces very strong cellular E6- and E7- specific cellular immune responses in mice and, as shown in regression experiments, efficiently controls growth of HPV 16 positive syngeneic tumors. This data demonstrates the potential of this vaccine candidate to control persistent HPV 16 infection that may lead to malignant disease. It also suggests that different sequence rearrangements influence the immunogenecity by an as yet unknown mechanism.}, language = {en} } @article{AllefeldBialonski2007, author = {Allefeld, Carsten and Bialonski, Stephan}, title = {Detecting synchronization clusters in multivariate time series via coarse-graining of Markov chains}, series = {Physical Review E}, volume = {76}, journal = {Physical Review E}, number = {6}, issn = {2470-0053}, doi = {10.1103/PhysRevE.76.066207}, pages = {066207}, year = {2007}, language = {en} } @article{AliaziziOezsoyluBakhshiSichanietal.2024, author = {Aliazizi, Fereshteh and {\"O}zsoylu, Dua and Bakhshi Sichani, Soroush and Khorshid, Mehran and Glorieux, Christ and Robbens, Johan and Sch{\"o}ning, Michael J. and Wagner, Patrick}, title = {Development and Calibration of a Microfluidic, Chip-Based Sensor System for Monitoring the Physical Properties of Water Samples in Aquacultures}, series = {Micromachines}, volume = {15}, journal = {Micromachines}, number = {6}, publisher = {MDPI}, address = {Basel}, issn = {2072-666X}, doi = {10.3390/mi15060755}, year = {2024}, abstract = {In this work, we present a compact, bifunctional chip-based sensor setup that measures the temperature and electrical conductivity of water samples, including specimens from rivers and channels, aquaculture, and the Atlantic Ocean. For conductivity measurements, we utilize the impedance amplitude recorded via interdigitated electrode structures at a single triggering frequency. The results are well in line with data obtained using a calibrated reference instrument. The new setup holds for conductivity values spanning almost two orders of magnitude (river versus ocean water) without the need for equivalent circuit modelling. Temperature measurements were performed in four-point geometry with an on-chip platinum RTD (resistance temperature detector) in the temperature range between 2 °C and 40 °C, showing no hysteresis effects between warming and cooling cycles. Although the meander was not shielded against the liquid, the temperature calibration provided equivalent results to low conductive Milli-Q and highly conductive ocean water. The sensor is therefore suitable for inline and online monitoring purposes in recirculating aquaculture systems.}, language = {en} } @article{AlhwarinFerreinScholl2014, author = {Alhwarin, Faraj and Ferrein, Alexander and Scholl, Ingrid}, title = {IR stereo kinect: improving depth images by combining structured light with IR stereo}, pages = {1 -- 9}, year = {2014}, language = {en} } @article{AlexyukBogoyavlenskiyAlexyuketal.2021, author = {Alexyuk, Madina and Bogoyavlenskiy, Andrey and Alexyuk, Pavel and Moldakhanov, Yergali and Berezin, Vladimir and Digel, Ilya}, title = {Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity}, series = {MicrobiologyOpen}, volume = {10}, journal = {MicrobiologyOpen}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2045-8827}, doi = {10.1002/mbo3.1142}, pages = {1 -- 10}, year = {2021}, abstract = {Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40\% and 37\% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.}, language = {en} } @article{AlexopoulosHoffschmidt2010, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard}, title = {Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus}, series = {Renewable Energy . 35 (2010), H. 7}, journal = {Renewable Energy . 35 (2010), H. 7}, isbn = {0960-1481}, pages = {1352 -- 1356}, year = {2010}, language = {en} } @article{AlexopoulosHoffschmidt2010, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard}, title = {Solarthermische Kraftwerke mit thermischen Speichern}, series = {Chemie Ingenieur Technik. 82 (2010), H. 9}, journal = {Chemie Ingenieur Technik. 82 (2010), H. 9}, isbn = {1522-2640}, pages = {1606 -- 1606}, year = {2010}, language = {de} } @article{AlexopoulosHoffschmidt2017, author = {Alexopoulos, Spiros and Hoffschmidt, Bernhard}, title = {Advances in solar tower technology}, series = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, volume = {6}, journal = {Wiley interdisciplinary reviews : Energy and Environment : WIREs}, number = {1}, publisher = {Wiley}, address = {Weinheim}, issn = {2041-840X}, doi = {10.1002/wene.217}, pages = {1 -- 19}, year = {2017}, language = {en} } @article{AlexopoulosBreitbachHoffschmidtetal.2008, author = {Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Stobbe, P.}, title = {Optimization of the geometry of porous SiC ceramic filtering modules using numerical methods}, series = {Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society}, journal = {Developments in porous, biological and geopolymer ceramics : a collection of papers presented at the 31st International Conference on Advanced Ceramics and Composites, January 21 - 26, 2007, Daytona Beach, Florida ; [papers presented at the Symposium on Porous Ceramics: Novel Developments and Applications] / ed.: Manuel Brito ... Vol. ed.: Jonathan Salem ... The American Ceramics Society}, publisher = {Wiley}, address = {Hoboken, NJ}, isbn = {9780470196403}, pages = {95 -- 104}, year = {2008}, language = {en} } @article{AlexopoulosBreitbachHoffschmidtetal.2008, author = {Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Stobbe, P.}, title = {Computational fluid flow of porous resic ceramic filtering modules and optimization of the channel edge form geometry}, series = {Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2}, journal = {Proceedings : April 14 - 18, 2008, Leipzig, Germany / hosted by VDI, Society for Chemical and Process Engineering . Vol 2}, publisher = {Filtech Exhibitions}, address = {Meerbusch}, pages = {300 -- 304}, year = {2008}, language = {en} } @article{Alexopoulos2012, author = {Alexopoulos, Spiros}, title = {Biogas systems: basics, biogas multifunction, principle of fermentation and hybrid application with a solar tower for the treatment of waste animal manure}, series = {Journal of Engineering Science and Technology Review}, volume = {5}, journal = {Journal of Engineering Science and Technology Review}, number = {4}, issn = {1791-2377}, pages = {48 -- 55}, year = {2012}, abstract = {Two of the main environmental problems of today's society are the continuously increasing production of organic wastes as well as the increase of carbon dioxide in the atmosphere and the related green house effect. A way to solve these problems is the production of biogas. Biogas is a combustible gas consisting of methane, carbon dioxide and small amounts of other gases and trace elements. Production of biogas through anaerobic digestion of animal manure and slurries as well as of a wide range of digestible organic wastes and agricultural residues, converts these substrates into electricity and heat and offers a natural fertiliser for agriculture. The microbiological process of decomposition of organic matter, in the absence of oxygen takes place in reactors, called digesters. Biogas can be used as a fuel in a gas turbine or burner and can be used in a hybrid solar tower system offering a solution for waste treatment of agricultural and animal residues. A solar tower system consists of a heliostat field, which concentrates direct solar irradiation on an open volumetric central receiver. The receiver heats up ambient air to temperatures of around 700°C. The hot air's heat energy is transferred to a steam Rankine cycle in a heat recovery steam generator (HRSG). The steam drives a steam turbine, which in turn drives a generator for producing electricity. In order to increase the operational hours of a solar tower power plant, a heat storage system and/ or hybridization may be considered. The advantage of solar-fossil hybrid power plants, compared to solar-only systems, lies in low additional investment costs due to an adaptable solar share and reduced technical and economical risks. On sunny days the hybrid system operates in a solar-only mode with the central receiver and on cloudy days and at night with the gas turbine only. As an alternative to methane gas, environmentally neutral biogas can be used for operating the gas turbine. Hence, the hybrid system is operated to 100\% from renewable energy sources}, language = {en} } @article{Alexopoulos2015, author = {Alexopoulos, Spiros}, title = {Simulation model for the transient process behaviour of solar aluminium recycling in a rotary kiln}, series = {Applied Thermal Engineering}, volume = {78}, journal = {Applied Thermal Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-4311}, doi = {10.1016/j.applthermaleng.2015.01.007}, pages = {387 -- 396}, year = {2015}, language = {en} } @article{AletseeBaumann1991, author = {Aletsee, Ludwig and Baumann, Marcus}, title = {A laboratory incubator equipped with facilities to automatically simulate natural irradiance}, series = {Boletim do Instituto Oceanogr{\´a}fico / Universidade de S{\~a}o Paulo}, volume = {Vol. 39}, journal = {Boletim do Instituto Oceanogr{\´a}fico / Universidade de S{\~a}o Paulo}, number = {No. 2}, issn = {1982-436X; 0080-6331}, pages = {155 -- 159}, year = {1991}, language = {en} } @article{AlebouyehSamamiPieperBreitbachetal.2014, author = {Alebouyeh Samami, Behzad and Pieper, Martin and Breitbach, Gerd and Hodapp, Josef}, title = {Heat production in the windings of the stators of electric machines under stationary condition}, series = {Heat and mass transfer}, volume = {50}, journal = {Heat and mass transfer}, publisher = {Springer}, address = {Heidelberg}, issn = {0947-7411 (Print) ; 1432-1181 (E-Journal)}, doi = {10.1007/s00231-014-1371-8}, pages = {1707 -- 1716}, year = {2014}, abstract = {In electric machines due to high currents and resistive losses (joule heating) heat is produced. To avoid damages by overheating the design of effective cooling systems is required. Therefore the knowledge of heat sources and heat transfer processes is necessary. The purpose of this paper is to illustrate a good and effective calculation method for the temperature analysis based on homogenization techniques. These methods have been applied for the stator windings in a slot of an electric machine consisting of copper wires and resin. The key quantity here is an effective thermal conductivity, which characterizes the heterogeneous wire resin-arrangement inside the stator slot. To illustrate the applicability of the method, the analysis of a simplified, homogenized model is compared with the detailed analysis of temperature behavior inside a slot of an electric machine according to the heat generation. We considered here only the stationary situation. The achieved numerical results are accurate and show that the applied homogenization technique works in practice. Finally the results of simulations for the two cases, the original model of the slot and the homogenized model chosen for the slot (unit cell), are compared to experimental results.}, language = {en} } @article{AlbrachtArampatzis2013, author = {Albracht, Kirsten and Arampatzis, Adamantios}, title = {Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans}, series = {European Journal of Applied Physiology}, volume = {113}, journal = {European Journal of Applied Physiology}, number = {6}, publisher = {Springer}, address = {Berlin}, issn = {1439-6327}, doi = {10.1007/s00421-012-2585-4}, pages = {1605 -- 1615}, year = {2013}, language = {en} } @article{AlbrachtArampatzis2006, author = {Albracht, Kirsten and Arampatzis, Adamantios}, title = {Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy}, series = {Biological Cybernetics}, volume = {95}, journal = {Biological Cybernetics}, number = {1}, issn = {1432-0770}, doi = {10.1007/s00422-006-0070-z}, pages = {87 -- 96}, year = {2006}, language = {en} } @article{AlbrachtArampatzisBaltzopoulos2008, author = {Albracht, Kirsten and Arampatzis, A. and Baltzopoulos, V.}, title = {Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo}, series = {Journal of Biomechanics}, volume = {41}, journal = {Journal of Biomechanics}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2008.04.020}, pages = {2211 -- 2218}, year = {2008}, language = {en} } @article{AlbannaLuekeSchubertetal.2019, author = {Albanna, Walid and L{\"u}ke, Jan Niklas and Schubert, Gerrit Alexander and Dibu{\´e}-Adjei, Maxine and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Steiger, Hans-Jakob and H{\"a}nggi, Daniel and Kamp, Marcel A. and Schneider, Toni and Neumaier, Felix}, title = {Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity}, series = {Molecular and Cellular Neuroscience}, volume = {96}, journal = {Molecular and Cellular Neuroscience}, number = {4}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1044-7431}, doi = {10.1016/j.mcn.2019.03.003}, pages = {35 -- 46}, year = {2019}, language = {en} } @article{AlbannaLuekeSjapicetal.2017, author = {Albanna, Walid and Lueke, Jan Niklas and Sjapic, Volha and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Sjapic, Sergej and Alpdogan, Serdan and Schneider, Toni and Schubert, Gerrit Alexander and Neumaier, Felix}, title = {Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina}, series = {Current Eye Research}, journal = {Current Eye Research}, number = {Article in press}, publisher = {Taylor \& Francis}, address = {London}, issn = {1460-2202}, doi = {10.1080/02713683.2017.1339807}, pages = {1 -- 9}, year = {2017}, language = {en} } @article{AlbannaKotliarLuekeetal.2018, author = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander}, title = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis}, series = {Plos one}, volume = {13}, journal = {Plos one}, number = {10}, publisher = {PLOS}, address = {San Francisco}, doi = {10.1371/journal.pone.0204689}, pages = {e0204689}, year = {2018}, abstract = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.}, language = {en} } @article{AlbannaConzenWeissetal.2021, author = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander}, title = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis}, series = {Frontiers in Neurology}, volume = {12}, journal = {Frontiers in Neurology}, number = {12}, issn = {1664-2295}, doi = {10.3389/fneur.2021.690183}, pages = {1 -- 15}, year = {2021}, abstract = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.}, language = {en} } @article{AlbannaConzenWeissetal.2016, author = {Albanna, W. and Conzen, C. and Weiss, M. and Clusmann, H. and Fuest, M. and Mueller, M. and Brockmann, M.A. and Vilser, W. and Schmidt-Trucks{\"a}ss, A. and Hoellig, A. and Seiz, M. and Thom{\´e}, C. and Kotliar, Konstantin and Schubert, G.A.}, title = {Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study}, series = {PLoS ONE}, volume = {11}, journal = {PLoS ONE}, number = {7}, publisher = {PLOS}, address = {San Francisco}, issn = {1932-6203}, doi = {10.1371/journal.pone.0158781}, pages = {13 Seiten}, year = {2016}, abstract = {Background Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2-14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results Image quality was satisfactory in the majority of cases (93.3\%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion. Conclusion RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.}, language = {en} } @article{AlKaidyTippkoetter2016, author = {Al-Kaidy, Huschyar and Tippk{\"o}tter, Nils}, title = {Superparamagnetic hydrophobic particles as shell material for digital microfluidic droplets and proof-of-principle reaction assessments with immobilized laccase}, series = {Engineering in Life Sciences}, volume = {16}, journal = {Engineering in Life Sciences}, number = {3}, publisher = {Wiley-VCH}, address = {Weinheim}, doi = {10.1002/elsc.201400124}, pages = {222 -- 230}, year = {2016}, abstract = {In the field of biotechnology and molecular biology, the use of small liquid volumes has significant advantages. In particular, screening and optimization runs with acceptable amounts of expensive and hardly available catalysts, reagents, or biomolecules are feasible with microfluidic technologies. The presented new microfluidic system is based on the inclusion of small liquid volumes by a protective shell of magnetizable microparticles. Hereby, discrete aqueous microreactor drops with volumes of 1-30 μL can be formed on a simple planar surface. A digital movement and manipulation of the microreactor is performed by overlapping magnetic forces. The magnetic forces are generated by an electrical coil matrix positioned below a glass plate. With the new platform technology, several discrete reaction compartments can be moved simultaneously on one surface. Due to the magnetic fields, the reactors can even be merged to initiate reactions by mixing or positioned above surface-immobilized catalysts and then opened by magnetic force. Comparative synthesis routes of the magnetizable shell particles and superhydrophobic glass slides including their performance and stability with the reaction platform are described. The influence of diffusive mass transport during the catalyzed reaction is discussed by evaluation finite element model of the microreactor. Furthermore, a first model dye reaction of the enzyme laccase has been established.}, language = {en} } @article{AlKaidyKuthanHeringetal.2016, author = {Al-Kaidy, Huschyar and Kuthan, Kai and Hering, Thomas and Tippk{\"o}tter, Nils}, title = {Aqueous droplets used as enzymatic microreactors and their electromagnetic actuation}, series = {Journal of Visualized Experiments}, journal = {Journal of Visualized Experiments}, number = {Issue 126}, issn = {1940-087X}, doi = {10.3791/54643}, year = {2016}, abstract = {For the successful implementation of microfluidic reaction systems, such as PCR and electrophoresis, the movement of small liquid volumes is essential. In conventional lab-on-a-chip-platforms, solvents and samples are passed through defined microfluidic channels with complex flow control installations. The droplet actuation platform presented here is a promising alternative. With it, it is possible to move a liquid drop (microreactor) on a planar surface of a reaction platform (lab-in-a-drop). The actuation of microreactors on the hydrophobic surface of the platform is based on the use of magnetic forces acting on the outer shell of the liquid drops which is made of a thin layer of superhydrophobic magnetite particles. The hydrophobic surface of the platform is needed to avoid any contact between the liquid core and the surface to allow a smooth movement of the microreactor. On the platform, one or more microreactors with volumes of 10 µL can be positioned and moved simultaneously. The platform itself consists of a 3 x 3 matrix of electrical double coils which accommodate either neodymium or iron cores. The magnetic field gradients are automatically controlled. By variation of the magnetic field gradients, the microreactors' magnetic hydrophobic shell can be manipulated automatically to move the microreactor or open the shell reversibly. Reactions of substrates and corresponding enzymes can be initiated by merging the microreactors or bringing them into contact with surface immobilized catalysts.}, language = {en} } @article{AlKaidyDuweHusteretal.2015, author = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Tim, Sieker and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Biotechnology and bioprocess engineering - from the first ullmann's article to recent trends}, series = {ChemBioEng Reviews}, volume = {2}, journal = {ChemBioEng Reviews}, number = {3}, publisher = {Wiley}, address = {Weinheim}, doi = {10.1002/cben.201500008}, pages = {175 -- 184}, year = {2015}, abstract = {For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.}, language = {en} } @article{AlKaidyDuweHusteretal.2014, author = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Sieker, Tim and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland}, title = {Biotechnologie und Bioverfahrenstechnik - Vom ersten Ullmanns Artikel bis hin zu aktuellen Forschungsthemen}, series = {Chemie Ingenieur Technik}, volume = {86}, journal = {Chemie Ingenieur Technik}, number = {12}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0009-286X}, doi = {10.1002/cite.201400083}, pages = {2215 -- 2225}, year = {2014}, abstract = {Biotechnologie und die mit ihr verbundenen technischen Prozesse pr{\"a}gen seit Jahrtausenden die Entwicklung der Menschheit. Ausgehend von empirischen Verfahren, insbesondere zur Herstellung von Lebensmitteln und t{\"a}glichen Gebrauchsg{\"u}tern, haben sich diese Disziplinen zu einem der innovativsten Zukunftsfelder entwickelt. Durch das immer detailliertere Verst{\"a}ndnis zellul{\"a}rer Vorg{\"a}nge k{\"o}nnen mittlerweile Produktionsst{\"a}mme gezielt optimiert werden. Im Zusammenspiel mit moderner Prozesstechnik k{\"o}nnen so eine Vielzahl von Bulk- und Feinchemikalien sowie Pharmazeutika effizient hergestellt werden. In diesem Artikel werden exemplarisch einige der aktuellen Trends vorgestellt.}, language = {de} } @article{AkimbekovZhubanovaMansurovetal.2010, author = {Akimbekov, Nuraly S. and Zhubanova, A. A. and Mansurov, Z. A. and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Use of Carbonized Rise Shell for the local treatment of wounds}, series = {Eurasian ChemTech Journal}, volume = {12}, journal = {Eurasian ChemTech Journal}, number = {2}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {2522-4867}, doi = {10.18321/ectj35}, pages = {133 -- 138}, year = {2010}, abstract = {On the model of musculocutaneous wound in rats, the effect of applicative sorption by carbonized rise shell (CRS) on the healing of festering wound was studied. It has been shown, that cytological changes end with rapid scar formation. The use of CRS at the period of severe purulent wound contributes to its favorable course, prevents the development of complications of the animals from sepsis.}, language = {en} } @article{AkimbekovQiaoDigeletal.2020, author = {Akimbekov, Nuraly S. and Qiao, Xiaohui and Digel, Ilya and Abdieva, Gulzhamal and Ualieva, Perizat and Zhubanova, Azhar}, title = {The effect of leonardite-derived amendments on soil microbiome structure and potato yield}, series = {Agriculture}, volume = {10}, journal = {Agriculture}, number = {Art. 147}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/agriculture10050147}, pages = {1 -- 17}, year = {2020}, abstract = {Humic substances originating from various organic matters can ameliorate soil properties, stimulate plant growth, and improve nutrient uptake. Due to the low calorific heating value, leonardite is rather unsuitable as fuel. However, it may serve as a potential source of humic substances. This study was aimed at characterizing the leonardite-based soil amendments and examining the effect of their application on the soil microbial community, as well as on potato growth and tuber yield. A high yield (71.1\%) of humic acid (LHA) from leonardite has been demonstrated. Parental leonardite (PL) and LHA were applied to soil prior to potato cultivation. The 16S rRNA sequencing of soil samples revealed distinct relationships between microbial community composition and the application of leonardite-based soil amendments. Potato tubers were planted in pots in greenhouse conditions. The tubers were harvested at the mature stage for the determination of growth and yield parameters. The results demonstrated that the LHA treatments had a significant effect on increasing potato growth (54.9\%) and tuber yield (66.4\%) when compared to the control. The findings highlight the importance of amending leonardite-based humic products for maintaining the biogeochemical stability of soils, for keeping their healthy microbial community structure, and for increasing the agronomic productivity of potato plants.}, language = {en} } @article{AkimbekovMansurovJandosovetal.2013, author = {Akimbekov, Nuraly S. and Mansurov, Zulkhair and Jandosov, J. and Digel, Ilya and Gossmann, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A.}, title = {Wound healing activity of carbonized rice husk}, publisher = {Trans Tech Publications, Switzerland}, address = {B{\"a}ch}, year = {2013}, abstract = {The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.}, subject = {Wundheilung}, language = {en} } @article{AkimbekovDigelZhubanova2014, author = {Akimbekov, Nuraly S. and Digel, Ilya and Zhubanova, A. A.}, title = {Advantages of creation of e-books in training of specialists biologists and biotechnologists}, series = {KazNU Bulletin. Biology series.}, volume = {60}, journal = {KazNU Bulletin. Biology series.}, number = {1}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {249 -- 252}, year = {2014}, abstract = {The necessity of e-books as a primary of learning, its opportunities for realization of competence during training biologist and biotechnologist specialists are determined. Definitions and requirements to the e-books, its advantages in comparison with traditional textbooks, and the ways of creation of e-books in the SunRav BookEditor program are considered.}, language = {ru} } @article{AkimbekovDigelZhubanova2013, author = {Akimbekov, Nuraly S. and Digel, Ilya and Zhubanova, A. A.}, title = {Investigation the Influence of Carbonized Material Based On Rice Husk on Viability and Migration of Fibroblasts in T3B3 Cell Culture}, series = {KazNU Bulletin. Biology series}, volume = {59}, journal = {KazNU Bulletin. Biology series}, number = {3/1}, issn = {1563-0218}, pages = {20 -- 23}, year = {2013}, language = {en} } @article{AkimbekovDigelTastambeketal.2021, author = {Akimbekov, Nuraly S. and Digel, Ilya and Tastambek, Kuanysh T. and Sherelkhan, Dinara K. and Jussupova, Dariya B. and Altynbay, Nazym P.}, title = {Low-rank coal as a source of humic substances for soil amendment and fertility management}, series = {Agriculture}, volume = {11}, journal = {Agriculture}, number = {12}, publisher = {MDPI}, address = {Basel}, issn = {2077-0472}, doi = {10.3390/agriculture11121261}, pages = {25 Seiten}, year = {2021}, abstract = {Humic substances (HS), as important environmental components, are essential to soil health and agricultural sustainability. The usage of low-rank coal (LRC) for energy generation has declined considerably due to the growing popularity of renewable energy sources and gas. However, their potential as soil amendment aimed to maintain soil quality and productivity deserves more recognition. LRC, a highly heterogeneous material in nature, contains large quantities of HS and may effectively help to restore the physicochemical, biological, and ecological functionality of soil. Multiple emerging studies support the view that LRC and its derivatives can positively impact the soil microclimate, nutrient status, and organic matter turnover. Moreover, the phytotoxic effects of some pollutants can be reduced by subsequent LRC application. Broad geographical availability, relatively low cost, and good technical applicability of LRC offer the advantage of easy fulfilling soil amendment and conditioner requirements worldwide. This review analyzes and emphasizes the potential of LRC and its numerous forms/combinations for soil amelioration and crop production. A great benefit would be a systematic investment strategy implicating safe utilization and long-term application of LRC for sustainable agricultural production.}, language = {en} }