@article{DemirciKurulganDemirciTrzewiketal.2009,
  author    = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l},
  title     = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {311 -- 312},
  year      = {2009},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1030 -- 1031},
  year      = {2004},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1046 -- 1047},
  year      = {2004},
  language  = {en}
}
@inproceedings{DachwaldXuFeldmannetal.2011,
  author    = {Dachwald, Bernd and Xu, Changsheng and Feldmann, Marco and Plescher, Engelbert and Digel, Ilya and Artmann, Gerhard},
  title     = {Development and testing of a subsurface probe for detection of life in deep ice : [abstract]},
  year      = {2011},
  abstract  = {We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).},
  subject      = {Eisschicht},
  language  = {en}
}
@article{BeckerWallangArtmannetal.2008,
  author    = {Becker, C. and Wallang, C. and Artmann, Gerhard and Jakse, G.},
  title     = {Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis},
  series = {International Journal of Artificial Organs, The},
  volume    = {31},
  journal   = {International Journal of Artificial Organs, The},
  number    = {7},
  issn      = {0391-3988},
  pages     = {583 -- 583},
  year      = {2008},
  language  = {en}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@inproceedings{BayerHeschelerArtmannetal.2019,
  author    = {Bayer, Robin and Hescheler, J{\"u}rgen and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Treating arterial hypertension in a cell culture well},
  series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  editor    = {Staat, Manfred and Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-22-6},
  doi       = {10.17185/duepublico/48750},
  pages     = {5 -- 6},
  year      = {2019},
  abstract  = {Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.},
  language  = {en}
}
@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  pages     = {Art. 16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}
@article{BassamDigelHescheleretal.2013,
  author    = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences},
  series = {BMC Biophysics},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  isbn      = {2046-1682},
  url       = {http://nbn-resolving.de/10.1186/2046-1682-6-1},
  pages     = {1 -- 14},
  year      = {2013},
  language  = {en}
}
@inproceedings{BassamDigelArtmann2009,
  author    = {Bassam, Rasha and Digel, Ilya and Artmann, Gerhard},
  title     = {Effect of nitric oxide on protein thermal stability : [abstract]},
  year      = {2009},
  abstract  = {As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.},
  subject      = {Stickstoffmonoxid},
  language  = {en}
}
@article{BassamArtmannHescheleretal.2011,
  author    = {Bassam, Rasha and Artmann, Gerhard and Hescheler, J{\"u}rgen and Graef, T. and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Arinkin, Vladimir and Gossmann, Matthias and Digel, Ilya},
  title     = {Alterations in human hemoglobin structure related to red blood cell storage},
  year      = {2011},
  abstract  = {The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@incollection{AzatKerimkulovaMansurovetal.2020,
  author    = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard},
  title     = {The Use of Fusicoccin as Anticancer Compound},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {New York},
  isbn      = {978-0-429-42864-7},
  doi       = {10.1201/9780429428647-8},
  pages     = {149 -- 172},
  year      = {2020},
  abstract  = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.},
  language  = {en}
}
@article{ArtmannZhouStacheBuettneretal.2002,
  author    = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]},
  title     = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.},
  series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  journal   = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  isbn      = {0140-0118},
  pages     = {698 -- 703},
  year      = {2002},
  language  = {en}
}
@article{ArtmannZerlinDigeletal.2007,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.},
  title     = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@article{ArtmannZerlinDigel2008,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya},
  title     = {Hemoglobin Senses Body Temperature},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {415 -- 447},
  year      = {2008},
  language  = {en}
}
@article{ArtmannZang1990,
  author    = {Artmann, Gerhard and Zang, Werner},
  title     = {Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen},
  series = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3},
  journal   = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3},
  isbn      = {0013-5585},
  pages     = {94 -- 96},
  year      = {1990},
  language  = {en}
}
@article{ArtmannTrzewikMallipattuetal.2001,
  author    = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Mallipattu, S. K. and Delano, F. A. [u.a.]},
  title     = {Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, J{\"u}rgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W},
  series = {The FASEB Journal. 15 (2001)},
  journal   = {The FASEB Journal. 15 (2001)},
  isbn      = {1530-6860},
  pages     = {1711 -- 1717},
  year      = {2001},
  language  = {en}
}
@article{ArtmannTrzewikAtes2002,
  author    = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Ates, M.},
  title     = {A novel method to quantify mechanical tension in cell monolayers. Trzewik, J{\"u}rgen; Ates, M., Artmann, Gerhard Michael},
  series = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1},
  journal   = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1},
  isbn      = {0013-5585},
  pages     = {379 -- 381},
  year      = {2002},
  language  = {en}
}
@article{ArtmannTrzewikSchmidSchoenbein2000,
  author    = {Artmann, Gerhard and Trzewik, J. and Schmid-Sch{\"o}nbein, G. W.},
  title     = {Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Sch{\"o}nbein, G. W.},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {521 -- 522},
  year      = {2000},
  language  = {en}
}
@book{ArtmannTemizArtmannZhubanovaetal.2018,
  author    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  title     = {Biological, physical and technical basics of cell engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7903-0},
  pages     = {xxiv, 481 Seiten ; Illustrationen, Diagramme},
  year      = {2018},
  language  = {en}
}
@article{ArtmannSungHornetal.1997,
  author    = {Artmann, Gerhard and Sung, K.-L. Paul and Horn, Thomas and Whittemore, Darren [u.a.]},
  title     = {Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu},
  series = {Biophysical journal. 72 (1997), H. 3},
  journal   = {Biophysical journal. 72 (1997), H. 3},
  isbn      = {1542-0086},
  pages     = {1434 -- 1441},
  year      = {1997},
  language  = {en}
}
@inproceedings{ArtmannStadlerEmbsetal.2010,
  author    = {Artmann, Gerhard and Stadler, Andreas M. and Embs, Jan P. and Zaccai, Giuseppe and B{\"u}ldt, Georg and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]},
  year      = {2010},
  abstract  = {The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@article{ArtmannShiAgostietal.1998,
  author    = {Artmann, Gerhard and Shi, Young de and Agosti, R. and Longhini, E.},
  title     = {A modified casson equation to characterize blood rheology for hypertension. Shi, Young de; Artmann, Gerhard Michael; Agosti, R.; Longhini, E.},
  series = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2},
  journal   = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2},
  isbn      = {1386-0291},
  pages     = {115 -- 127},
  year      = {1998},
  language  = {en}
}
@article{ArtmannSchmidSchoenbeinSchroederetal.1988,
  author    = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Schr{\"o}der, Susanne and Grebe, R. [u.a.]},
  title     = {Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Sch{\"o}nbein, H.; Schr{\"o}der, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.},
  series = {Arzneimittelforschung. 38 (1988), H. 5},
  journal   = {Arzneimittelforschung. 38 (1988), H. 5},
  isbn      = {0004-4172},
  pages     = {710 -- 716},
  year      = {1988},
  language  = {en}
}
@article{ArtmannSchmidSchoenbeinGrebeetal.1988,
  author    = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Grebe, R. and Teitel, P. [u.a.]},
  title     = {Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Sch{\"o}nbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schr{\"o}der, Susanne},
  series = {Drug Development Research. 14 (1988), H. 3-4},
  journal   = {Drug Development Research. 14 (1988), H. 3-4},
  isbn      = {1098-2299},
  pages     = {205 -- 211},
  year      = {1988},
  language  = {en}
}
@article{ArtmannSchmidSchoenbein1987,
  author    = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H.},
  title     = {The microscope-photometrical-monolayer-technique- a new principle for analyzing the distribution of rheological responses in pathological and experimentally modified red cell populations. Artmann, Gerhard Michael; Schmid-Sch{\"o}nbein, H.},
  series = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987},
  journal   = {Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987},
  publisher = {Excerpta Medica},
  address   = {Amsterdam [u.a.]},
  isbn      = {0444809511},
  pages     = {475 -- 477},
  year      = {1987},
  language  = {en}
}
@article{ArtmannSchikarsky1993,
  author    = {Artmann, Gerhard and Schikarsky, C.},
  title     = {Ginkgo Biloba extract (EGb 761) protects red blood cells from oxidative damage. Artmann, Gerhard Michael; Schikarsky, C.},
  series = {Clinical Hemorheology. 13 (1993), H. 4},
  journal   = {Clinical Hemorheology. 13 (1993), H. 4},
  isbn      = {0271-5198},
  pages     = {529 -- 539},
  year      = {1993},
  language  = {en}
}
@incollection{ArtmannMeruvuKizildagetal.2018,
  author    = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l},
  title     = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures},
  series = {Biological, Physical and Technical Basics of Cell Engineering},
  booktitle = {Biological, Physical and Technical Basics of Cell Engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7904-7},
  doi       = {10.1007/978-981-10-7904-7_7},
  pages     = {157 -- 192},
  year      = {2018},
  abstract  = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.},
  language  = {en}
}
@misc{ArtmannLinderBayeretal.2017,
  author    = {Artmann, Gerhard and Linder, Peter and Bayer, Robin and Gossmann, Matthias},
  title     = {Celldrum electrode arrangement for measuring mechanical stress [Patent of invention]},
  publisher = {WIPO},
  address   = {Geneva},
  pages     = {18 Seiten},
  year      = {2017},
  abstract  = {The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.},
  language  = {en}
}
@article{ArtmannLiZiemeretal.1996,
  author    = {Artmann, Gerhard and Li, Anlan and Ziemer, J. and Schneider, G. [u.a.]},
  title     = {A photometric method to analyze induced erythrocyte shape changes. Artmann, Gerhard Michael; Li, Anlan; Ziemer, J.; Schneider, G.; Sahm, U.: ; Ziemer, J.; Schneider, G.; Sahm, U.},
  series = {Biorheology. 33 (1996), H. 3},
  journal   = {Biorheology. 33 (1996), H. 3},
  isbn      = {0006-355x},
  pages     = {251 -- 265},
  year      = {1996},
  language  = {en}
}
@article{ArtmannLiSeipeltetal.1999,
  author    = {Artmann, Gerhard and Li, Anlan and Seipelt, H. and M{\"u}ller, C. [u.a.]},
  title     = {Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; M{\"u}ller, C.;Shi, Yong de; Artmann, Gerhard Michael},
  series = {Pharmacology and Toxicology. 85 (1999)},
  journal   = {Pharmacology and Toxicology. 85 (1999)},
  isbn      = {0902-9938},
  pages     = {206 -- 211},
  year      = {1999},
  language  = {en}
}
@article{ArtmannLi1994,
  author    = {Artmann, Gerhard and Li, Anlan},
  title     = {Dihydroergocryptine maintains erythrocyte fluidity in acidotic and hyperosmolar suspensions modelling hypoxic and ischemic microcirculation. Li, Anlan; Artmann, Gerhard Michael},
  series = {Clinical Hemorheology. 15 (1994), H. 2},
  journal   = {Clinical Hemorheology. 15 (1994), H. 2},
  isbn      = {0271-5198},
  pages     = {133 -- 146},
  year      = {1994},
  language  = {en}
}
@article{ArtmannKelemenPorstetal.1998,
  author    = {Artmann, Gerhard and Kelemen, Christina and Porst, Dariusz and B{\"u}ldt, G. [u.a.]},
  title     = {Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; B{\"u}ldt, G.; Chien, S.},
  series = {Biophysical Journal. 75 (1998), H. 6},
  journal   = {Biophysical Journal. 75 (1998), H. 6},
  isbn      = {1542-0086},
  pages     = {3179 -- 3183},
  year      = {1998},
  language  = {en}
}
@article{ArtmannKelemenPorstetal.1998,
  author    = {Artmann, Gerhard and Kelemen, C. and Porst, Dariusz and B{\"u}ldt, G.},
  title     = {Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß {\"u}ber versteckte Materialeigenschaften zellul{\"a}rer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; B{\"u}ldt, G. ; Chien, Shu},
  series = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1},
  journal   = {Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1},
  isbn      = {1862-278},
  pages     = {446 -- 447},
  year      = {1998},
  language  = {en}
}
@article{ArtmannKelemenChien2001,
  author    = {Artmann, Gerhard and Kelemen, C. and Chien, S.},
  title     = {Temperature transition of human hemoglobin at body temperature: effects of calcium. Kelemen, C.; Chien, S.; Artmann, Gerhard Michael},
  series = {Biophysical journal. 80 (2001), H. 6},
  journal   = {Biophysical journal. 80 (2001), H. 6},
  isbn      = {1542-0086},
  pages     = {2622 -- 2630},
  year      = {2001},
  language  = {en}
}
@article{ArtmannHueckRossiteretal.2008,
  author    = {Artmann, Gerhard and Hueck, Isgard S. and Rossiter, Katharine and Schmid-Sch{\"o}nbein, Geert W.},
  title     = {Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Sch{\"o}nbein, Geert W.},
  series = {Microcirculation. 15 (2008), H. 6},
  journal   = {Microcirculation. 15 (2008), H. 6},
  isbn      = {1549-8719},
  pages     = {531 -- 542},
  year      = {2008},
  language  = {en}
}
@article{ArtmannHueckHollwegetal.2000,
  author    = {Artmann, Gerhard and Hueck, I. S. and Hollweg, H. G. and Schmid-Sch{\"o}nbein, G. W.},
  title     = {Chlorpromazine modulates the Morphological Macro- and Microstructure of Endothelial Cells. Hueck, I. S.; Hollweg, H. G.; Schmid-Sch{\"o}nbein, G. W.; Artmann, Gerhard Michael},
  series = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5},
  journal   = {American Journal of Physiology. Cell Physiology. 278 (2000), H. 5},
  isbn      = {1522-1563},
  pages     = {873 -- 878},
  year      = {2000},
  language  = {en}
}
@article{ArtmannHovavGoldfarbetal.1999,
  author    = {Artmann, Gerhard and Hovav, T. and Goldfarb, A. and Yedgar, S. [u.a.]},
  title     = {Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G.},
  series = {British Journal of Haematology. 106 (1999), H. 1},
  journal   = {British Journal of Haematology. 106 (1999), H. 1},
  isbn      = {1365-2141},
  pages     = {178 -- 181},
  year      = {1999},
  language  = {en}
}
@article{ArtmannGrebeHomrighausenetal.1988,
  author    = {Artmann, Gerhard and Grebe, R. and Homrighausen, A. and Wolff, H. and [u.a.],},
  title     = {Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Sch{\"o}nbein, H.},
  series = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation},
  journal   = {12. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation},
  publisher = {Karger [u.a.]},
  address   = {Basel [u.a.]},
  pages     = {196 -- 200},
  year      = {1988},
  language  = {en}
}
@article{ArtmannGorbatenkovaPanasenko2000,
  author    = {Artmann, Gerhard and Gorbatenkova, E. A. and Panasenko, O. M.},
  title     = {Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M.},
  series = {Membrane and cell biology. 13 (2000), H. 4},
  journal   = {Membrane and cell biology. 13 (2000), H. 4},
  isbn      = {1023-6597},
  pages     = {537 -- 546},
  year      = {2000},
  language  = {en}
}
@article{ArtmannDigelZerlinetal.2009,
  author    = {Artmann, Gerhard and Digel, Ilya and Zerlin, Kay and Maggakis-Kelemen, Christina and Linder, Peter and Porst, Dariusz and Kayser, Peter and Stadler, David and Dikta, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Hemoglobin senses body temperature},
  series = {European Biophysics Journal},
  volume    = {38},
  journal   = {European Biophysics Journal},
  number    = {5},
  isbn      = {0175-7571},
  pages     = {589 -- 600},
  year      = {2009},
  language  = {en}
}
@inproceedings{ArtmannDigelLinderetal.2011,
  author    = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Temiz Artmann, Ayseg{\"u}l},
  title     = {Biophysical and Engineering Contributions to Plant Research},
  year      = {2011},
  abstract  = {Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in-situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.},
  subject      = {Pflanzenphysiologie},
  language  = {en}
}
@article{ArtmannDigelLinderetal.2008,
  author    = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz},
  title     = {Mechanism of haemoglobin sensing body temperature},
  series = {Tissue Engineering Part A. 14 (2008), H. 5},
  journal   = {Tissue Engineering Part A. 14 (2008), H. 5},
  isbn      = {1937-3341},
  pages     = {754 -- 754},
  year      = {2008},
  language  = {en}
}
@article{ArtmannBaeumlerVoigtetal.2000,
  author    = {Artmann, Gerhard and B{\"a}umler, H. and Voigt, A. and Mitl{\"o}hner, R. [u.a.]},
  title     = {Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. B{\"a}umler, H., Artmann, Gerhard Michael; Voigt, A., Mitl{\"o}hner, R., Neu, B., Kiesewetter, H.},
  series = {Journal of Microencapsulation. 17 (2000), H. 5},
  journal   = {Journal of Microencapsulation. 17 (2000), H. 5},
  isbn      = {1464-5246},
  pages     = {651 -- 655},
  year      = {2000},
  language  = {en}
}
@article{ArtmannBurnsCanavesetal.2004,
  author    = {Artmann, Gerhard and Burns, Laura and Canaves, Jaume M. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature},
  series = {European Biophysics Journal. 33 (2004), H. 6},
  journal   = {European Biophysics Journal. 33 (2004), H. 6},
  isbn      = {1432-1017},
  pages     = {490 -- 496},
  year      = {2004},
  language  = {en}
}
@article{Artmann1986,
  author    = {Artmann, Gerhard},
  title     = {A microscopic photometric method for measuring erythrocyte deformability. Artmann, Gerhard Michael},
  series = {Clinical Hemorheology. 6 (1986)},
  journal   = {Clinical Hemorheology. 6 (1986)},
  isbn      = {0271-5198},
  pages     = {617 -- 627},
  year      = {1986},
  language  = {en}
}
@article{Artmann1996,
  author    = {Artmann, Gerhard},
  title     = {2nd International Conference on Medical Biorheology (ICMB). Shanghai, China, September 13-15, 1995. Shi, Young de, Artmann, Gerhard Michael, Meiselman, Herbert J.},
  series = {Biorheology. 33 (1996), H. 6},
  journal   = {Biorheology. 33 (1996), H. 6},
  isbn      = {0006-355x},
  pages     = {505 -- 507},
  year      = {1996},
  language  = {en}
}
@article{Artmann1995,
  author    = {Artmann, Gerhard},
  title     = {Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael},
  series = {Biorheology. 32 (1995), H. 5},
  journal   = {Biorheology. 32 (1995), H. 5},
  isbn      = {0006-355x},
  pages     = {553 -- 570},
  year      = {1995},
  language  = {en}
}
@book{Artmann2008,
  author    = {Artmann, Gerhard},
  title     = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  year      = {2008},
  language  = {en}
}
@article{Artmann2000,
  author    = {Artmann, Gerhard},
  title     = {Cellular engineering - a challenge for engineers? / Artmann, G. M.},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {449},
  year      = {2000},
  language  = {en}
}