@article{ScheerMclaughlinRodeetal.2014, author = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.}, title = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057885}, pages = {1022 -- 1030}, year = {2014}, abstract = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.}, language = {en} } @article{ScheerKapelyukhRodeetal.2015, author = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Oswald, Stefan and Busch, Diana and Mclaughlin, Lesley A. and Lin, De and Henderson, Colin J. and Wolf, C. Roland}, title = {Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model}, series = {Drug Metabolism and Disposition}, volume = {43}, journal = {Drug Metabolism and Disposition}, number = {11}, publisher = {ASPET}, address = {Bethesda}, issn = {1521-009x}, doi = {10.1124/dmd.115.065656}, pages = {1679 -- 1690}, year = {2015}, language = {en} } @article{ScheerKapelyukhRodeetal.2012, author = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Buechel, Sandra and Wolf, C. Roland}, title = {Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines}, series = {Molecular Pharmacology}, volume = {82}, journal = {Molecular Pharmacology}, number = {6}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.112.080036}, pages = {1022 -- 1029}, year = {2012}, abstract = {Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction.}, language = {en} } @article{ScheerKapelyukhMcEwanetal.2012, author = {Scheer, Nico and Kapelyukh, Yury and McEwan, Jillian and Beuger, Vincent and Stanley, Lesley A. and Rode, Anja and Wolf, C. Roland}, title = {Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines}, series = {Molecular Pharmacology}, volume = {81}, journal = {Molecular Pharmacology}, number = {1}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.111.075192}, pages = {63 -- 72}, year = {2012}, abstract = {The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25\% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.}, language = {en} } @article{ScheerHendersonKapelyukhetal.2019, author = {Scheer, Nico and Henderson, Colin James and Kapelyukh, Yury and Rode, Anja and Mclaren, Aileen W. and MacLeod, Alastair Kenneth and Lin, De and Wright, Jayne and Stanley, Lesley and Wolf, C. Roland}, title = {An extensively humanised mouse model to predict pathways of drug disposition, drug/drug interactions, and to facilitate the design of clinical trials}, series = {Drug Metabolism and Disposition}, journal = {Drug Metabolism and Disposition}, number = {Early view}, doi = {10.1124/dmd.119.086397}, pages = {69 Seiten}, year = {2019}, language = {en} } @article{ScheerGrothHansetal.2001, author = {Scheer, Nico and Groth, Anne and Hans, Stefan and Campos-Ortega, Jos{\´e} A.}, title = {An instructive function for Notch in promoting gliogenesis in the zebrafish retina}, series = {Development}, volume = {128}, journal = {Development}, number = {7}, issn = {0950-1991}, pages = {1099 -- 1107}, year = {2001}, language = {en} } @incollection{ScheerChuSalphatietal.2016, author = {Scheer, Nico and Chu, Xiaoyan and Salphati, Laurent and Zamek-Gliszczynski, Maciej J.}, title = {Knockout and humanized animal models to study membrane transporters in drug development}, series = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, booktitle = {Drug Transporters: Volume 1: Role and Importance in ADME and Drug Development}, editor = {Nicholls, Glynis}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, isbn = {978-1-78262-379-3}, doi = {10.1039/9781782623793-00298}, pages = {298 -- 332}, year = {2016}, language = {en} } @article{ScheerCamposOrtega1999, author = {Scheer, Nico and Campos-Ortega, Jos{\´e} A.}, title = {Use of the Gal4-UAS technique for targeted gene expression in the zebrafish}, series = {Mechanism of Development}, volume = {80}, journal = {Mechanism of Development}, number = {2}, issn = {0925-4773}, doi = {10.1016/S0925-4773(98)00209-3}, pages = {153 -- 158}, year = {1999}, language = {en} } @article{ScheerBalimaneHaywardetal.2012, author = {Scheer, Nico and Balimane, Praveen and Hayward, Michael D. and Buechel, Sandra and Kauselmann, Gunther and Wolf, C. Roland}, title = {Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line}, series = {Drug Metabolism and Disposition}, volume = {40}, journal = {Drug Metabolism and Disposition}, number = {11}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/dmd.112.047605}, pages = {2212 -- 2218}, year = {2012}, abstract = {The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(-/-)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(-/-) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.}, language = {en} } @article{ScheeleOertelBongaertsetal.2013, author = {Scheele, Sandra and Oertel, Dan and Bongaerts, Johannes and Evers, Stefan and Hellmuth, Hendrik and Maurer, Karl-Heinz and Bott, Michael and Freudl, Roland}, title = {Secretory production of an FAD cofactor-containing cytosolic enzyme (sorbitol-xylitol oxidase from Streptomyces coelicolor) using the twin-arginine translocation (Tat) pathway of Corynebacterium glutamicum}, series = {Microbial biotechnology}, journal = {Microbial biotechnology}, publisher = {Wiley-Blackwell}, address = {Oxford}, issn = {1751-7915}, pages = {202 -- 206}, year = {2013}, language = {en} } @inproceedings{SchartnerLoebDachwaldetal.2009, author = {Schartner, Karl-Heinz and Loeb, H. W. and Dachwald, Bernd and Ohndorf, Andreas}, title = {Perspectives of electric propulsion for outer planetary and deep space missions}, series = {European Planetary Science Congress 2009}, booktitle = {European Planetary Science Congress 2009}, pages = {416 -- 416}, year = {2009}, abstract = {Solar-electric propulsion (SEP) is superior with respect to payload capacity, flight time and flexible launch window to the conventional interplanetary transfer method using chemical propulsion combined with gravity assists. This fact results from the large exhaust velocities of electric low-thrust propulsion and is favourable also for missions to the giant planets, Kuiper-belt objects and even for a heliopause probe (IHP) as shown in three studies by the authors funded by DLR. They dealt with a lander for Europa and a sample return mission from a mainbelt asteroid [1], with the TANDEM mission [2]; the third recent one investigates electric propulsion for the transfer to the edge of the solar system. All studies are based on triple-junction solar arrays, on rf-ion thrusters of the qualified RIT-22 type and they use the intelligent trajectory optimization program InTrance [3].}, language = {en} } @article{SchaelAtanasyanBerdugoetal.2019, author = {Schael, S. and Atanasyan, A. and Berdugo, J. and Bretz, T. and Czupalla, Markus and Dachwald, Bernd and Doetinchem, P. von and Duranti, M. and Gast, H. and Karpinski, W. and Kirn, T. and L{\"u}belsmeyer, K. and Ma{\~n}a, C. and Marrocchesi, P.S. and Mertsch, P. and Moskalenko, I.V. and Schervan, T. and Schluse, M. and Schr{\"o}der, K.-U. and Schultz von Dratzig, A. and Senatore, C. and Spies, L. and Wakely, S.P. and Wlochal, M. and Uglietti, D. and Zimmermann, J.}, title = {AMS-100: The next generation magnetic spectrometer in space - An international science platform for physics and astrophysics at Lagrange point 2}, series = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment}, volume = {944}, journal = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment}, number = {162561}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0168-9002}, doi = {10.1016/j.nima.2019.162561}, year = {2019}, language = {en} } @article{SchaeferHoefkenSchuba2011, author = {Schaefer, Thomas and H{\"o}fken, Hans-Wilhelm and Schuba, Marko}, title = {Windows Phone 7 from a Digital Forensics' Perspective}, publisher = {Springer}, address = {Berlin}, year = {2011}, language = {en} } @article{SawadaNakazawaTakenagaetal.2014, author = {Sawada, Kazuaki and Nakazawa, Hirokazu and Takenaga, Shoko and Hizawa, Takeshi and Futagawa, Masato and Dasai, Fumihiro and Sakurai, Takashi and Okumura, Koichi and Hattori, Toshiaki and Ishida, Makoto}, title = {Multimodal bioimage sensor}, series = {IEICE transactions on fundamentals of electronics, communidations and computer sciences}, volume = {E97-A (2014)}, journal = {IEICE transactions on fundamentals of electronics, communidations and computer sciences}, number = {3}, publisher = {IEICE}, address = {Tokyo}, issn = {0916-8508 (Print) ; 1745-1337 (Online)}, doi = {10.1587/transfun.E97.A.726}, pages = {726 -- 733}, year = {2014}, abstract = {To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.}, language = {en} } @article{SavitskayaZhantlessovaKistaubayevaetal.2023, author = {Savitskaya, Irina and Zhantlessova, Sirina and Kistaubayeva, Aida and Ignatova, Ludmila and Shokatayeva, Dina and Sinyavsky, Yuriy and Kushugulova, Almagul and Digel, Ilya}, title = {Prebiotic cellulose-pullulan matrix as a "vehicle" for probiotic biofilm delivery to the host large intestine}, series = {Polymers}, journal = {Polymers}, number = {16(1)}, publisher = {MDPI}, address = {Basel}, doi = {10.3390/polym16010030}, pages = {Artikel 30}, year = {2023}, abstract = {This study describes the development of a new combined polysaccharide-matrix-based technology for the immobilization of Lactobacillus rhamnosus GG (LGG) bacteria in biofilm form. The new composition allows for delivering the bacteria to the digestive tract in a manner that improves their robustness compared with planktonic cells and released biofilm cells. Granules consisting of a polysaccharide matrix with probiotic biofilms (PMPB) with high cell density (>9 log CFU/g) were obtained by immobilization in the optimized nutrient medium. Successful probiotic loading was confirmed by fluorescence microscopy and scanning electron microscopy. The developed prebiotic polysaccharide matrix significantly enhanced LGG viability under acidic (pH 2.0) and bile salt (0.3\%) stress conditions. Enzymatic extract of feces, mimicking colon fluid in terms of cellulase activity, was used to evaluate the intestinal release of probiotics. PMPB granules showed the ability to gradually release a large number of viable LGG cells in the model colon fluid. In vivo, the oral administration of PMPB granules in rats resulted in the successful release of probiotics in the colon environment. The biofilm-forming incubation method of immobilization on a complex polysaccharide matrix tested in this study has shown high efficacy and promising potential for the development of innovative biotechnologies.}, language = {en} } @inproceedings{SavitskayaKistaubayevaAkimbekovetal.2013, author = {Savitskaya, Irina S. and Kistaubayeva, Aida S. and Akimbekov, Nuraly S. and Digel, Ilya and Zhubanova, Azhar A.}, title = {Performance of Bio-Composite Carbonized Materials in Probiotic Applications}, series = {World Academy of Science, Engineering and Technology International Journal of Biotechnology and Bioengineering}, volume = {7}, booktitle = {World Academy of Science, Engineering and Technology International Journal of Biotechnology and Bioengineering}, number = {7}, pages = {685 -- 689}, year = {2013}, language = {en} } @incollection{SavitskayaKistaubayevaAkimbekovetal.2020, author = {Savitskaya, Irina S. and Kistaubayeva, Aida S. and Akimbekov, Nuraly S. and Digel, Ilya and Shokatayeva, Dina and Zhubanova, Azhar Achmet}, title = {Prospective Use of Probiotics Immobilized on Sorbents with Nanostructured Surfaces}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {Singapore}, isbn = {978-981-4800-27-3}, doi = {10.1201/9780429428647-12}, pages = {229 -- 267}, year = {2020}, abstract = {Activated carbons are known as excellent adsorbents. Their applications include the adsorptive removal of color, odor, taste, undesirable organic and inorganic pollutants from drinking and waste water; air purification in inhabited spaces; purification of many chemicals, pharmaceutical products and many others. This chapter elucidates the role of normal microflora in the maintenance of human health and presents materials on possible clinical displays of microecological infringements and ways of their correction. It presents new developments concerning new probiotics with immobilized Lactobacillus and Bacillus. The chapter considers the mechanisms of the intestine disbacteriosis correction by sorbed probiotics. It demonstrates the advantages and creation prospects of immobilized probiotics developed on the basis of carbonized rice husk. There are great prospects for the development of medical biotechnology due to use of carbon sorbents with a nanostructured surface. Microbial communities form a biocenosis of the biotope and together with the host organism create permanent or temporary ecosystems.}, language = {en} } @article{SavitskayaKistaubayevaIgnatovaetal.2019, author = {Savitskaya, I.S. and Kistaubayeva, A.S. and Ignatova, L.V. and Digel, Ilya}, title = {Antimicrobial and wound healing properties of a bacterial cellulose based material containing B. subtilis cells}, series = {Heliyon}, volume = {5}, journal = {Heliyon}, number = {10}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2405-8440}, doi = {10.1016/j.heliyon.2019.e02592}, pages = {Artikelnummer e02592}, year = {2019}, language = {en} } @article{SavitskayaKistaubayevaDigeletal.2017, author = {Savitskaya, I. S. and Kistaubayeva, A. S. and Digel, Ilya and Shokatayeva, D. H.}, title = {Physicochemical and Antibacterial Properties of Composite Films Based on Bacterial Cellulose and Chitosan for Wound Dressing Materials}, series = {Eurasian Chemico-Technological Journal}, volume = {19}, journal = {Eurasian Chemico-Technological Journal}, number = {3}, issn = {2522-4867}, doi = {10.18321/ectj670}, pages = {255 -- 264}, year = {2017}, language = {en} } @inproceedings{SauerbornLiebenstundRaueetal.2017, author = {Sauerborn, Markus and Liebenstund, Lena and Raue, Markus and Mang, Thomas and Herrmann, Ulf and Dueing, Andreas}, title = {Analytic method for material aging and quality analyzing to forecast long time stability of plastic micro heliostat components}, series = {AIP Conference Proceedings}, volume = {1850}, booktitle = {AIP Conference Proceedings}, number = {1}, doi = {10.1063/1.4984388}, pages = {030045-1 -- 030045-8}, year = {2017}, language = {en} } @inproceedings{SauerbornKlimekHoffschmidtetal.2012, author = {Sauerborn, Markus and Klimek, J. and Hoffschmidt, Bernhard and Essen, H. and Sieger, S. and Biegel, G. and G{\"o}ttsche, Joachim and Hilger, Patrick}, title = {Eurosun 2012 : radar technology for heliostat posititon control}, series = {Eurosun 2012 : Solar energy for a brighter future : conference proceedings : Rijeka, 18.-22.09.2012}, booktitle = {Eurosun 2012 : Solar energy for a brighter future : conference proceedings : Rijeka, 18.-22.09.2012}, address = {Rijeka}, pages = {ID 80}, year = {2012}, language = {en} } @inproceedings{SauerbornHoffschmidtTelleetal.2012, author = {Sauerborn, Markus and Hoffschmidt, Bernhard and Telle, R. and Wagner, M.}, title = {Heatable optical analyse system for high temperature absorbers}, series = {30th ISES Biennial Solar World Congress 2011 : : Kassel, Germany, 28 August - 2 September 2011. Vol. 5}, booktitle = {30th ISES Biennial Solar World Congress 2011 : : Kassel, Germany, 28 August - 2 September 2011. Vol. 5}, publisher = {Curran}, address = {Red Hook, NY}, organization = {International Solar Energy Society}, isbn = {978-1-61839-364-7}, pages = {3852 -- 3860}, year = {2012}, language = {en} } @inproceedings{SauerbornArshadiRohrmoser2012, author = {Sauerborn, Markus and Arshadi, S. and Rohrmoser, R.}, title = {Influence of clouds and aerosols to the haze of the sunshape}, series = {30th ISES Biennial Solar World Congress 2011 : Kassel, Germany, 28 August - 2 September 2011. Vol. 5}, booktitle = {30th ISES Biennial Solar World Congress 2011 : Kassel, Germany, 28 August - 2 September 2011. Vol. 5}, publisher = {Curran}, address = {Red Hook, NY}, organization = {International Solar Energy Society}, pages = {3887 -- 3894}, year = {2012}, language = {en} } @inproceedings{Sauerborn2011, author = {Sauerborn, Markus}, title = {Investigations to the influence of clouds and aerosols to the haze of the sunshape}, series = {SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain}, booktitle = {SolarPACES 2011 : concentrating solar power and chemical energy systems : 20 - 23 September, 2011, Granada, Spain}, address = {Granada}, pages = {1 CD-ROM}, year = {2011}, language = {en} } @inproceedings{SattlerSchneiderAngeleetal.2022, author = {Sattler, Johannes Christoph and Schneider, Iesse Peer and Angele, Florian and Atti, Vikrama and Teixeira Boura, Cristiano Jos{\´e} and Herrmann, Ulf}, title = {Development of heliostat field calibration methods: Theory and experimental test results}, series = {SolarPACES 2022 conference proceedings}, booktitle = {SolarPACES 2022 conference proceedings}, number = {1}, publisher = {TIB Open Publishing}, address = {Hannover}, issn = {2751-9899 (online)}, doi = {10.52825/solarpaces.v1i.678}, pages = {9 Seiten}, year = {2022}, abstract = {In this work, three patent pending calibration methods for heliostat fields of central receiver systems (CRS) developed by the Solar-Institut J{\"u}lich (SIJ) of the FH Aachen University of Applied Sciences are presented. The calibration methods can either operate in a combined mode or in stand-alone mode. The first calibration method, method A, foresees that a camera matrix is placed into the receiver plane where it is subjected to concentrated solar irradiance during a measurement process. The second calibration method, method B, uses an unmanned aerial vehicle (UAV) such as a quadrocopter to automatically fly into the reflected solar irradiance cross-section of one or more heliostats (two variants of method B were tested). The third calibration method, method C, foresees a stereo central camera or multiple stereo cameras installed e.g. on the solar tower whereby the orientations of the heliostats are calculated from the location detection of spherical red markers attached to the heliostats. The most accurate method is method A which has a mean accuracy of 0.17 mrad. The mean accuracy of method B variant 1 is 1.36 mrad and of variant 2 is 1.73 mrad. Method C has a mean accuracy of 15.07 mrad. For method B there is great potential regarding improving the measurement accuracy. For method C the collected data was not sufficient for determining whether or not there is potential for improving the accuracy.}, language = {en} } @article{SattlerRoegerSchwarzboezletal.2020, author = {Sattler, Johannes Christoph and R{\"o}ger, Marc and Schwarzb{\"o}zl, Peter and Buck, Reiner and Macke, Ansgar and Raeder, Christian and G{\"o}ttsche, Joachim}, title = {Review of heliostat calibration and tracking control methods}, series = {Solar Energy}, volume = {207}, journal = {Solar Energy}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.solener.2020.06.030}, pages = {110 -- 132}, year = {2020}, abstract = {Large scale central receiver systems typically deploy between thousands to more than a hundred thousand heliostats. During solar operation, each heliostat is aligned individually in such a way that the overall surface normal bisects the angle between the sun's position and the aim point coordinate on the receiver. Due to various tracking error sources, achieving accurate alignment ≤1 mrad for all the heliostats with respect to the aim points on the receiver without a calibration system can be regarded as unrealistic. Therefore, a calibration system is necessary not only to improve the aiming accuracy for achieving desired flux distributions but also to reduce or eliminate spillage. An overview of current larger-scale central receiver systems (CRS), tracking error sources and the basic requirements of an ideal calibration system is presented. Leading up to the main topic, a description of general and specific terms on the topics heliostat calibration and tracking control clarifies the terminology used in this work. Various figures illustrate the signal flows along various typical components as well as the corresponding monitoring or measuring devices that indicate or measure along the signal (or effect) chain. The numerous calibration systems are described in detail and classified in groups. Two tables allow the juxtaposition of the calibration methods for a better comparison. In an assessment, the advantages and disadvantages of individual calibration methods are presented.}, language = {en} } @inproceedings{SattlerChicoCaminosUerlingsetal.2020, author = {Sattler, Johannes Christoph and Chico Caminos, Ricardo Alexander and {\"U}rlings, Nicolas and Dutta, Siddharth and Ruiz, Victor and Kalogirou, Soteris and Ktistis, Panayiotis and Agathokleous, Rafaela and Jung, Christian and Alexopoulos, Spiros and Atti, Vikrama Nagababu and Teixeira Boura, Cristiano Jos{\´e} and Herrmann, Ulf}, title = {Operational experience and behaviour of a parabolic trough collector system with concrete thermal energy storage for process steam generation in Cyprus}, series = {AIP Conference Proceedings}, booktitle = {AIP Conference Proceedings}, number = {2303}, doi = {10.1063/5.0029278}, pages = {140004-1 -- 140004-10}, year = {2020}, abstract = {As part of the transnational research project EDITOR, a parabolic trough collector system (PTC) with concrete thermal energy storage (C-TES) was installed and commissioned in Limassol, Cyprus. The system is located on the premises of the beverage manufacturer KEAN Soft Drinks Ltd. and its function is to supply process steam for the factory's pasteurisation process [1]. Depending on the factory's seasonally varying capacity for beverage production, the solar system delivers between 5 and 25 \% of the total steam demand. In combination with the C-TES, the solar plant can supply process steam on demand before sunrise or after sunset. Furthermore, the C-TES compensates the PTC during the day in fluctuating weather conditions. The parabolic trough collector as well as the control and oil handling unit is designed and manufactured by Protarget AG, Germany. The C-TES is designed and produced by CADE Soluciones de Ingenier{\´i}a, S.L., Spain. In the focus of this paper is the description of the operational experience with the PTC, C-TES and boiler during the commissioning and operation phase. Additionally, innovative optimisation measures are presented.}, language = {en} } @inproceedings{SattlerAttiAlexopoulosetal.2022, author = {Sattler, Johannes Christoph and Atti, Vikrama and Alexopoulos, Spiros and Teixeira Boura, Cristiano Jos{\´e} and Herrmann, Ulf and Dutta, Siddharth and Kioutsioukis, Ioannis}, title = {DNI forecast tool for the smart operation of a parabolic trough collector system with concrete thermal energy storage: Theory, results and outlook}, series = {SolarPACES 2022 conference proceedings}, booktitle = {SolarPACES 2022 conference proceedings}, number = {1}, publisher = {TIB Open Publishing}, address = {Hannover}, issn = {2751-9899 (online)}, doi = {10.52825/solarpaces.v1i.731}, pages = {9 Seiten}, year = {2022}, abstract = {This work presents a basic forecast tool for predicting direct normal irradiance (DNI) in hourly resolution, which the Solar-Institut J{\"u}lich (SIJ) is developing within a research project. The DNI forecast data shall be used for a parabolic trough collector (PTC) system with a concrete thermal energy storage (C-TES) located at the company KEAN Soft Drinks Ltd in Limassol, Cyprus. On a daily basis, 24-hour DNI prediction data in hourly resolution shall be automatically produced using free or very low-cost weather forecast data as input. The purpose of the DNI forecast tool is to automatically transfer the DNI forecast data on a daily basis to a main control unit (MCU). The MCU automatically makes a smart decision on the operation mode of the PTC system such as steam production mode and/or C-TES charging mode. The DNI forecast tool was evaluated using historical data of measured DNI from an on-site weather station, which was compared to the DNI forecast data. The DNI forecast tool was tested using data from 56 days between January and March 2022, which included days with a strong variation in DNI due to cloud passages. For the evaluation of the DNI forecast reliability, three categories were created and the forecast data was sorted accordingly. The result was that the DNI forecast tool has a reliability of 71.4 \% based on the tested days. The result fulfils SIJ's aim to achieve a reliability of around 70 \%, but SIJ aims to still improve the DNI forecast quality.}, language = {en} } @inproceedings{SattlerAlexopoulosChicoCaminosetal.2019, author = {Sattler, Johannes Christoph and Alexopoulos, Spiros and Chico Caminos, Ricardo Alexander and Mitchell, John C. and Ruiz, Victor C. and Kalogirou, Soteris and Ktistis, Panayiotis K. and Teixeira Boura, Cristiano Jos{\´e} and Herrmann, Ulf}, title = {Dynamic simulation model of a parabolic trough collector system with concrete thermal energy storage for process steam generation}, series = {AIP Conference Proceedings}, volume = {2126}, booktitle = {AIP Conference Proceedings}, issn = {0094243X}, doi = {10.1063/1.5117663}, pages = {150007-1 -- 150007-8}, year = {2019}, language = {en} } @article{SaretzkiBergmannDahmannetal.2021, author = {Saretzki, Charlotte and Bergmann, Ole and Dahmann, Peter and Janser, Frank and Keimer, Jona and Machado, Patricia and Morrison, Audry and Page, Henry and Pluta, Emil and St{\"u}bing, Felix and K{\"u}pper, Thomas}, title = {Are small airplanes safe with regards to COVID-19 transmission?}, series = {Journal of Travel Medicine}, volume = {28}, journal = {Journal of Travel Medicine}, number = {7}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1708-8305}, doi = {10.1093/jtm/taab105}, year = {2021}, language = {en} } @techreport{SansomLawsonTuchoetal.2016, author = {Sansom, M. and Lawson, R.M. and Tucho, R. and Kendrick, C. and Ogden, R. and Resalati, S. and Garay, R. and D{\"o}ring, Bernd and Reger, V. and Gilbert, J. and Heikkinen, J. and Hemmila, K.}, title = {Building in active thermal mass into steel structures (BATIMASS) - EUR 28166EN}, publisher = {Publications Office of the European Union}, address = {Luxembourg}, organization = {European Commission}, isbn = {978-92-79-63176-4}, issn = {1831-9424}, doi = {10.2777/25999}, pages = {147 Seiten}, year = {2016}, abstract = {The main objective of the BATIMASS project was to address how the energy balance in relatively lightweight steel buildings can be improved by building in 'active thermal mass' (ATM) into the building fabric. This was achieved through concept design, dynamic thermal modelling and testing of a number of potentially viable systems and concepts. A significant programme of thermal simulation modelling was undertaken utilising the thermally equivalent slab (TES) concept to model the passive thermal capacity effect of profiled, composite metal floor decks. It is apparent from the modelling results that thermal mass is a highly complex phenomenon which is highly dependent upon building type, occupancy patterns, climate and many other aspects of the building design and servicing strategy. The ATM systems developed, both conceptually and for prototype testing, focussed on water-cooled composite slabs, the Cofradal floor system and the phase change material (PCM) Energain. In addition to laboratory testing of prototypes, whole building monitoring was undertaken at the Kubik building in Spain and the RWTH test building in Germany. Advanced thermal modelling was also undertaken to estimate the likely benefits of the ATM concept designs developed and for comparison with the test results. In addition to thermal testing, structural tests were conducted on composite floor specimens incorporating embedded water pipes. This Final Report presents the results of the activities carried out under this RFCS contract RFSR CT 2012 00033. The work carried out is reported in six major sections corresponding to the technical Work Packages of the project. Only summaries of the work carried out are provided in this report; all work undertaken is fully reported in the formal project deliverables.}, language = {en} } @article{SanderRoy2004, author = {Sander, Volker and Roy, Alain}, title = {GARA: A Uniform Quality of Service Architecture / Roy, Alain ; Sander, Volker}, series = {Grid resource management : state of the art and future trends / ed. by Jarek Nabrzyski; Jennifer M. Schopf; Jan W\&\#796;eglarz}, journal = {Grid resource management : state of the art and future trends / ed. by Jarek Nabrzyski; Jennifer M. Schopf; Jan W\&\#796;eglarz}, publisher = {Kluwer Academic Publ.}, address = {Boston}, isbn = {1-4020-7575-8}, pages = {377 -- 394}, year = {2004}, language = {en} } @book{SanderRoy2002, author = {Sander, Volker and Roy, Alain}, title = {Advance Reservation API / Roy, Alain ; Sander, Volker}, publisher = {Global Grid Forum}, pages = {26 S.}, year = {2002}, language = {en} } @article{SanderFosterFidleretal.2004, author = {Sander, Volker and Foster, Ian T. and Fidler, Markus and Roy, Alain}, title = {End-to-end quality of service for high-end applications / Foster, Ian T. ; Fidler, Markus ; Roy, Alain ; Sander, Volker ; Winkler, Linda}, series = {Computer Communications. 27 (2004), H. 14}, journal = {Computer Communications. 27 (2004), H. 14}, isbn = {0140-3664}, pages = {1375 -- 1388}, year = {2004}, language = {en} } @article{SanderFosterRoyetal.2000, author = {Sander, Volker and Foster, Ian and Roy, Alain and Winkler, Linda}, title = {A differentiated services implementation for high-performance TCP flows}, series = {Computer Networks. 34 (2000), H. 6}, journal = {Computer Networks. 34 (2000), H. 6}, isbn = {1389-1286}, pages = {915 -- 929}, year = {2000}, language = {en} } @article{SanderFidlerKlimala2005, author = {Sander, Volker and Fidler, Markus and Klimala, Wojciech}, title = {Traffic shaping in aggregate-based networks: implementation and analysis / Fidler, Markus ; Sander, Volker ; Klimala, Wojciech}, series = {Computer Communications. 28 (2005), H. 3}, journal = {Computer Communications. 28 (2005), H. 3}, isbn = {0140-3664}, pages = {274 -- 286}, year = {2005}, language = {en} } @article{SanderFidler2004, author = {Sander, Volker and Fidler, Markus}, title = {A parameter based admission control for differentiated services networks / Fidler, Markus ; Sander, Volker}, series = {Computer Networks. 44 (2004), H. 4}, journal = {Computer Networks. 44 (2004), H. 4}, isbn = {1389-1286}, pages = {463 -- 479}, year = {2004}, language = {en} } @article{SanderErwinHuber1999, author = {Sander, Volker and Erwin, Dietmar and Huber, Valentina}, title = {High-performance computer management based on Java}, series = {Future Generation Computer Systems. 15 (1999), H. 3}, journal = {Future Generation Computer Systems. 15 (1999), H. 3}, isbn = {0167-739X}, pages = {425 -- 432}, year = {1999}, language = {en} } @article{SanderCzajkowskiFosteretal.2002, author = {Sander, Volker and Czajkowski, K. and Foster, I. and Kesselman, C.}, title = {SNAP: A Protocol for Negotiating Service Level Agreements and Coordinating Resource Management in Distributed Systems / Czajkowski, K. ; Foster, I. ; Kesselman, C. ; Sander, V. ; Tuecke, S.}, series = {Job Scheduling Strategies for Parallel Processing : 8th InternationalWorkshop, JSSPP 2002 Edinburgh, Scotland, UK, July 24, 2002. Revised Papers}, journal = {Job Scheduling Strategies for Parallel Processing : 8th InternationalWorkshop, JSSPP 2002 Edinburgh, Scotland, UK, July 24, 2002. Revised Papers}, publisher = {Springer}, address = {Berlin}, isbn = {3-540-00172-7}, pages = {153 -- 183}, year = {2002}, language = {en} } @book{Sander2003, author = {Sander, Volker}, title = {Design and evaluation of a bandwidth broker that provides network quality of service for grid applications}, publisher = {John von Neumann Institute for Computing (NIC)}, address = {J{\"u}lich}, isbn = {3-00-010002-4}, pages = {VIII, 184 S. : Ill., graph. Darst.}, year = {2003}, language = {en} } @book{Sander2004, author = {Sander, Volker}, title = {Optical Network Infrastructure for Grid / Simeonidou, Dimitra ... (ed.)}, publisher = {Global Grid Forum}, pages = {56 S.}, year = {2004}, language = {en} } @book{Sander2004, author = {Sander, Volker}, title = {Networking Issues for Grid Infrastructure / Sander, Volker (ed.)}, publisher = {Global Grid Forum}, pages = {52 S.}, year = {2004}, language = {en} } @incollection{SamuelssonScheerWilsonetal.2017, author = {Samuelsson, K. and Scheer, Nico and Wilson, I. and Wolf, C.R. and Henderson, C.J.}, title = {Genetically Humanized Animal Models}, series = {Comprehensive Medicinal Chemistry III. 3rd Edition}, booktitle = {Comprehensive Medicinal Chemistry III. 3rd Edition}, editor = {Chackalamannil, Samuel}, publisher = {Elsevier}, address = {Saint Louis}, isbn = {978-0-12-803201-5}, doi = {10.1016/B978-0-12-409547-2.12376-5}, pages = {130 -- 149}, year = {2017}, abstract = {Genetically humanized mice for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging as promising in vivo models for improved prediction of the pharmacokinetic, drug-drug interaction, and safety characteristics of compounds in humans. This is an overview on the genetically humanized and chimeric liver-humanized mouse models, which are illustrated with examples of their utility in drug metabolism and toxicity studies. The models are compared to give guidance for selection of the most appropriate model by highlighting advantages and disadvantages to be carefully considered when used for studies in drug discovery and development.}, language = {en} } @article{SammFaissnerMoersetal.1993, author = {Samm, Doris and Faissner, H. and Moers, T. and Priem, R.}, title = {Modular wall-less drift chamber for muon detection at the LHC / H. Faissner, Th. Moers, R. Priem, ... , D. Samm [u.a.]}, series = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 330 (1993), H. 1-2}, journal = {Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 330 (1993), H. 1-2}, pages = {76 -- 82}, year = {1993}, language = {en} } @book{SammFaissnerHenrigsetal.1982, author = {Samm, Doris and Faissner, H. and Henrigs, W. and Preussger, A.}, title = {Further evidence for the radiative decay of a light, penetrating particle / Faissner, H. ; Heinrigs, W. ; Preussger, A. ; Samm, D.}, publisher = {Technische Hochschule}, address = {Aachen}, pages = {16}, year = {1982}, language = {en} } @article{SammFaissnerHeinrigsetal.1989, author = {Samm, Doris and Faissner, H. and Heinrigs, W. and Preussger, A.}, title = {Search for the two-photon decay of a light penetrating particle from a 590 MeV proton beam dump / Faissner, H.; Heinrigs, W.; Preussger, A.; Reitz, J.; Samm, D. [u.a.]}, series = {Zeitschrift f{\"u}r Physik, C Particles and Fields. 44 (1989), H. 4}, journal = {Zeitschrift f{\"u}r Physik, C Particles and Fields. 44 (1989), H. 4}, pages = {557 -- 566}, year = {1989}, language = {en} } @article{SammFaissnerGoettlicheretal.1992, author = {Samm, Doris and Faissner, H. and G{\"o}ttlicher, P. and Matela, H.}, title = {Search for scalar and pseudoscalar bosons emitted in nuclear decays via their interactions / Faissner, H.; Goettlicher, P. ; Matela, H. ; Samm, D.}, series = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 341 (1992), H. 3}, journal = {Zeitschrift f{\"u}r Physik A Hadrons and Nuclei. 341 (1992), H. 3}, pages = {359 -- 364}, year = {1992}, language = {en} } @article{SammFaissnerFrenzeletal.1980, author = {Samm, Doris and Faissner, H. and Frenzel, E. and Heinrigs, W.}, title = {Limit on axion decay into an electron pair / H. Faissner, E. Frenzel, W. Heinrigs, A. Preussger, D. Samm und U. Samm}, series = {Physics Letters B. Vol. 96 (1980), H. Issues 1-2}, journal = {Physics Letters B. Vol. 96 (1980), H. Issues 1-2}, pages = {201 -- 205}, year = {1980}, language = {en} } @article{SammFaissnerFrenzeletal.1980, author = {Samm, Doris and Faissner, H. and Frenzel, E. and Heinrigs, W.}, title = {Observation of the two-photon decay of a light penetrating particle / H. Faissner, E. Frenzel, W. Heinrigs, A. Preussger, D. Samm und U. Samm}, series = {Physics Letters B. Vol. 103 (1980), H. Issues 3}, journal = {Physics Letters B. Vol. 103 (1980), H. Issues 3}, pages = {234 -- 240}, year = {1980}, language = {en} } @article{SammBosetti1990, author = {Samm, Doris and Bosetti, P.-C.}, title = {Testmessungen an einem grossflaechigen (Durchmesser 35 cm) Photomultiplier Test measurements of a large-area (diameter 35 cm) photomultiplier / Bosetti, P.-C.; ... Samm, D. [u.a.]}, series = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1}, journal = {Verhandlungen der Deutschen Physikalischen Gesellschaft. 25 (1990), H. 1}, pages = {33 -- 33}, year = {1990}, language = {en} }