@article{KurulganDemirciLinderDemircietal.2009,
  author    = {Kurulgan Demirci, Eylem and Linder, Peter and Demirci, Taylan and Trzewik, J{\"u}rgen and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension of endothelial cells: An LPS based in-vitro sepsis model},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {307 -- 308},
  year      = {2009},
  language  = {en}
}
@article{KurulganDemirciDemirciLinderetal.2012,
  author    = {Kurulgan Demirci, Eylem and Demirci, Taylan and Linder, Peter and Trzewik, J{\"u}rgen and Gierkowski, Jessica Ricarda and Gossmann, Matthias and Kayser, Peter and Porst, Dariusz and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells},
  series = {Journal of Bioscience and Bioengineering},
  volume    = {113},
  journal   = {Journal of Bioscience and Bioengineering},
  number    = {2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1347-4421},
  doi       = {10.1016/j.jbiosc.2012.03.019},
  pages     = {212 -- 219},
  year      = {2012},
  abstract  = {All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models.},
  language  = {en}
}
@article{KurulganDemirciDemirciTrzewiketal.2011,
  author    = {Kurulgan Demirci, Eylem and Demirci, T. and Trzewik, J{\"u}rgen and Linder, Peter and Karakulah, G. and Artmann, Gerhard and Sakizli, M. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation},
  series = {Cellular and molecular bioengineering. 4 (2011), H. 1},
  journal   = {Cellular and molecular bioengineering. 4 (2011), H. 1},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {1865-5025},
  pages     = {46 -- 55},
  year      = {2011},
  language  = {en}
}
@article{KozhalakovaZhubanovaMansurovetal.2010,
  author    = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell},
  series = {Science of Central Asia (2010)},
  journal   = {Science of Central Asia (2010)},
  pages     = {50 -- 54},
  year      = {2010},
  language  = {en}
}
@article{KowalskiLinderZierkeetal.2016,
  author    = {Kowalski, Julia and Linder, Peter and Zierke, S. and Wulfen, B. van and Clemens, J. and Konstantinidis, K. and Ameres, G. and Hoffmann, R. and Mikucki, J. and Tulaczyk, S. and Funke, O. and Blandfort, D. and Espe, Clemens and Feldmann, Marco and Francke, Gero and Hiecker, S. and Plescher, Engelbert and Sch{\"o}ngarth, Sarah and Dachwald, Bernd and Digel, Ilya and Artmann, Gerhard and Eliseev, D. and Heinen, D. and Scholz, F. and Wiebusch, C. and Macht, S. and Bestmann, U. and Reineking, T. and Zetzsche, C. and Schill, K. and F{\"o}rstner, R. and Niedermeier, H. and Szumski, A. and Eissfeller, B. and Naumann, U. and Helbing, K.},
  title     = {Navigation technology for exploration of glacier ice with maneuverable melting probes},
  series = {Cold Regions Science and Technology},
  journal   = {Cold Regions Science and Technology},
  number    = {123},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0165-232X},
  doi       = {10.1016/j.coldregions.2015.11.006},
  pages     = {53 -- 70},
  year      = {2016},
  abstract  = {The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept.},
  language  = {en}
}
@article{KaulKoshkaryevArtmannetal.2008,
  author    = {Kaul, D. K. and Koshkaryev, A. and Artmann, Gerhard and Barshtein, G. and Yedgar, S.},
  title     = {Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance},
  series = {American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4},
  volume    = {295},
  journal   = {American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4},
  number    = {4},
  issn      = {1522-1539},
  pages     = {H1788 -- H1793},
  year      = {2008},
  language  = {en}
}
@article{GossmannFrotscherLinderetal.2016,
  author    = {Goßmann, Matthias and Frotscher, Ralf and Linder, Peter and Bayer, Robin and Epple, U. and Staat, Manfred and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells},
  series = {Cellular physiology and biochemistry},
  volume    = {38},
  journal   = {Cellular physiology and biochemistry},
  number    = {3},
  publisher = {Karger},
  address   = {Basel},
  issn      = {1421-9778 (Online)},
  doi       = {10.1159/000443124},
  pages     = {1182 -- 1198},
  year      = {2016},
  abstract  = {Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential.},
  language  = {en}
}
@article{EijckDemmelArtmannetal.2011,
  author    = {Eijck, Lambert van and Demmel, Franz and Artmann, Gerhard and Stadtler, Andreas Maximilian},
  title     = {Macromolecular dynamics in red blood cells investigated using neutron spectroscopy},
  series = {Journal of the Royal Society Interface},
  volume    = {8},
  journal   = {Journal of the Royal Society Interface},
  number    = {57},
  publisher = {The Royal Society},
  address   = {London},
  isbn      = {1742-5689},
  pages     = {590 -- 600},
  year      = {2011},
  language  = {en}
}
@incollection{DuongSeifarthTemizArtmannetal.2018,
  author    = {Duong, Minh Tuan and Seifarth, Volker and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Staat, Manfred},
  title     = {Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold},
  series = {Biological, Physical and Technical Basics of Cell Engineering},
  booktitle = {Biological, Physical and Technical Basics of Cell Engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7904-7},
  doi       = {10.1007/978-981-10-7904-7_9},
  pages     = {209 -- 232},
  year      = {2018},
  abstract  = {Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries.},
  language  = {en}
}
@article{DigelZhubanovaNojimaetal.2004,
  author    = {Digel, Ilya and Zhubanova, Azhar A. and Nojima, H. and Artmann, Gerhard},
  title     = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology},
  series = {Biotechnologija : teorija i praktika (2004)},
  journal   = {Biotechnologija : teorija i praktika (2004)},
  isbn      = {1028-9399},
  pages     = {46 -- 52},
  year      = {2004},
  language  = {en}
}
@inproceedings{DigelTemizArtmannNojimaetal.2003,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard},
  title     = {Effects of plasma generated ions on bacteria : [poster]},
  year      = {2003},
  abstract  = {Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death.},
  subject      = {Clusterion},
  language  = {en}
}
@inproceedings{DigelTemizArtmannNojimaetal.2003,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard},
  title     = {Some peculiarities of application of cluster ions generated by plasma in respect of indoor air purification :[abstract]},
  year      = {2003},
  abstract  = {Recently, the SHARP Corporation, Japan, has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances.},
  subject      = {Clusterion},
  language  = {en}
}
@inproceedings{DigelTemizArtmannNojimaetal.2003,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nojima, H. and Artmann, Gerhard},
  title     = {Plasma-generated cluster ions' effects on indoor microflora : [abstract]},
  year      = {2003},
  abstract  = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered.},
  subject      = {Clusterion},
  language  = {en}
}
@article{DigelTemizArtmannNishikawaetal.2004,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Nishikawa, K. and Artmann, Gerhard},
  title     = {Cluster air-ion effects on bacteria and moulds},
  series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1040 -- 1041},
  year      = {2004},
  language  = {en}
}
@inproceedings{DigelTemizArtmannArtmannetal.2003,
  author    = {Digel, Ilya and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Nojima, H.},
  title     = {Plasma cluster ions (PCI) influence on microbial cells viability : [abstract]},
  year      = {2003},
  abstract  = {Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp.},
  subject      = {Clusterion},
  language  = {en}
}
@incollection{DigelSadykovTemizArtmannetal.2015,
  author    = {Digel, Ilya and Sadykov, R. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations},
  series = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies},
  booktitle = {Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies},
  publisher = {Nova Science Publ.},
  isbn      = {9781634826990},
  pages     = {75 -- 99},
  year      = {2015},
  language  = {en}
}
@inproceedings{DigelLeimenaDachwaldetal.2010,
  author    = {Digel, Ilya and Leimena, W. and Dachwald, Bernd and Linder, Peter and Porst, Dariusz and Kayser, Peter and Funke, O. and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {In-situ biological decontamination of an ice melting probe : [abstract]},
  year      = {2010},
  abstract  = {The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting.},
  subject      = {Sonde},
  language  = {en}
}
@article{DigelKayserArtmann2008,
  author    = {Digel, Ilya and Kayser, Peter and Artmann, Gerhard},
  title     = {Molecular processes in biological thermosensation},
  series = {Journal of Biophysics. 2008 (2008)},
  journal   = {Journal of Biophysics. 2008 (2008)},
  isbn      = {1687-8000},
  pages     = {1 -- 9},
  year      = {2008},
  language  = {en}
}
@inproceedings{DigelDachwaldArtmannetal.2009,
  author    = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.},
  title     = {A concept of a probe for particle analysis and life detection in icy environments},
  year      = {2009},
  abstract  = {A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa's ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live.},
  subject      = {Sonde},
  language  = {en}
}
@article{DigelDachwaldArtmannetal.2009,
  author    = {Digel, Ilya and Dachwald, Bernd and Artmann, Gerhard and Linder, Peter and Funke, O.},
  title     = {A concept of a probe for particle analysis and life detection in icy environments},
  pages     = {1 -- 24},
  year      = {2009},
  language  = {en}
}
@article{DemirciKurulganDemirciTrzewiketal.2009,
  author    = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l},
  title     = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress},
  series = {IUBMB Life. 61 (2009), H. 3},
  journal   = {IUBMB Life. 61 (2009), H. 3},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  isbn      = {1521-6543},
  pages     = {311 -- 312},
  year      = {2009},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1030 -- 1031},
  year      = {2004},
  language  = {en}
}
@article{DemirciTrzewikLinderetal.2004,
  author    = {Demirci, T. and Trzewik, J. and Linder, Peter and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison},
  series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  journal   = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2},
  isbn      = {0932-4666},
  pages     = {1046 -- 1047},
  year      = {2004},
  language  = {en}
}
@inproceedings{DachwaldXuFeldmannetal.2011,
  author    = {Dachwald, Bernd and Xu, Changsheng and Feldmann, Marco and Plescher, Engelbert and Digel, Ilya and Artmann, Gerhard},
  title     = {Development and testing of a subsurface probe for detection of life in deep ice : [abstract]},
  year      = {2011},
  abstract  = {We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).},
  subject      = {Eisschicht},
  language  = {en}
}
@article{BorkKelemenBisellietal.2000,
  author    = {Bork, M. and Kelemen, C. and Biselli, Manfred and Artmann, Gerhard},
  title     = {Biophysikalische Charakterisierung ex vivo kultivierter menschlicher Erythrozythen},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {471 -- 472},
  year      = {2000},
  language  = {de}
}
@article{BeckerWallangArtmannetal.2008,
  author    = {Becker, C. and Wallang, C. and Artmann, Gerhard and Jakse, G.},
  title     = {Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis},
  series = {International Journal of Artificial Organs, The},
  volume    = {31},
  journal   = {International Journal of Artificial Organs, The},
  number    = {7},
  issn      = {0391-3988},
  pages     = {583 -- 583},
  year      = {2008},
  language  = {en}
}
@article{BayerTemizArtmannDigeletal.2020,
  author    = {Bayer, Robin and Temiz Artmann, Ayseg{\"u}l and Digel, Ilya and Falkenstein, Julia and Artmann, Gerhard and Creutz, Till and Hescheler, J{\"u}rgen},
  title     = {Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model},
  series = {Cellular Physiology and Biochemistry},
  volume    = {54},
  journal   = {Cellular Physiology and Biochemistry},
  publisher = {Cell Physiol Biochem Press},
  address   = {D{\"u}sseldorf},
  issn      = {1421-9778},
  doi       = {10.33594/000000225},
  pages     = {371 -- 383},
  year      = {2020},
  abstract  = {Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6\% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5\% and 50nM verapamil by 2,8\%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis.},
  language  = {en}
}
@inproceedings{BayerHeschelerArtmannetal.2019,
  author    = {Bayer, Robin and Hescheler, J{\"u}rgen and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Treating arterial hypertension in a cell culture well},
  series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW},
  editor    = {Staat, Manfred and Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-22-6},
  doi       = {10.17185/duepublico/48750},
  pages     = {5 -- 6},
  year      = {2019},
  abstract  = {Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching.},
  language  = {en}
}
@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  pages     = {Art. 16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}
@article{BassamDigelHescheleretal.2013,
  author    = {Bassam, Rasha and Digel, Ilya and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences},
  series = {BMC Biophysics},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  isbn      = {2046-1682},
  url       = {http://nbn-resolving.de/10.1186/2046-1682-6-1},
  pages     = {1 -- 14},
  year      = {2013},
  language  = {en}
}
@inproceedings{BassamDigelArtmann2009,
  author    = {Bassam, Rasha and Digel, Ilya and Artmann, Gerhard},
  title     = {Effect of nitric oxide on protein thermal stability : [abstract]},
  year      = {2009},
  abstract  = {As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not.},
  subject      = {Stickstoffmonoxid},
  language  = {en}
}
@article{BassamArtmannHescheleretal.2011,
  author    = {Bassam, Rasha and Artmann, Gerhard and Hescheler, J{\"u}rgen and Graef, T. and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Linder, Peter and Kayser, Peter and Arinkin, Vladimir and Gossmann, Matthias and Digel, Ilya},
  title     = {Alterations in human hemoglobin structure related to red blood cell storage},
  year      = {2011},
  abstract  = {The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing.},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@incollection{AzatKerimkulovaMansurovetal.2020,
  author    = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard},
  title     = {The Use of Fusicoccin as Anticancer Compound},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {New York},
  isbn      = {978-0-429-42864-7},
  doi       = {10.1201/9780429428647-8},
  pages     = {149 -- 172},
  year      = {2020},
  abstract  = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.},
  language  = {en}
}
@article{ArtmannZhouStacheBuettneretal.2002,
  author    = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]},
  title     = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.},
  series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  journal   = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  isbn      = {0140-0118},
  pages     = {698 -- 703},
  year      = {2002},
  language  = {en}
}
@article{ArtmannZerlinDigeletal.2007,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.},
  title     = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@article{ArtmannZerlinDigel2008,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya},
  title     = {Hemoglobin Senses Body Temperature},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {415 -- 447},
  year      = {2008},
  language  = {en}
}
@article{ArtmannZang1990,
  author    = {Artmann, Gerhard and Zang, Werner},
  title     = {Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen},
  series = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3},
  journal   = {Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3},
  isbn      = {0013-5585},
  pages     = {94 -- 96},
  year      = {1990},
  language  = {en}
}
@article{ArtmannZang1990,
  author    = {Artmann, Gerhard and Zang, Werner},
  title     = {Vollautomatische Messung rheologischer Parameter roter Blutzellen},
  series = {Biomedizinische Technik / Biomedical Engineering},
  volume    = {35},
  journal   = {Biomedizinische Technik / Biomedical Engineering},
  number    = {S3},
  issn      = {0013-5585},
  pages     = {94 -- 96},
  year      = {1990},
  language  = {de}
}
@article{ArtmannWitte1991,
  author    = {Artmann, Gerhard and Witte, Ch.},
  title     = {Expertensystem f{\"u}r Personal Computer zur Strukturbestimmung des Circulus Arteriosus Willisii mittels transkranieller Dopplersonografie. Witte, Ch.; Artmann, Gerhard Michael},
  series = {Biomedizinische Technik = Biomedical engineering. 36 (1991)},
  journal   = {Biomedizinische Technik = Biomedical engineering. 36 (1991)},
  isbn      = {0013-5585},
  pages     = {228 -- 230},
  year      = {1991},
  language  = {de}
}
@article{ArtmannVogelZinketal.2000,
  author    = {Artmann, Gerhard and Vogel, A. and Zink, S. and Stache, O.},
  title     = {Entwicklung eines automatisierten, computergesteuerten Permeabilit{\"a}tsanalysators zur Messung an Endothelzellen / Vogel, A. ; Zinke, S. ; Stache, O. ; K{\"o}nigsfeld, J. ; Artmann, G.},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {479 -- 480},
  year      = {2000},
  language  = {de}
}
@article{ArtmannTrzewikMallipattuetal.2001,
  author    = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Mallipattu, S. K. and Delano, F. A. [u.a.]},
  title     = {Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, J{\"u}rgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W},
  series = {The FASEB Journal. 15 (2001)},
  journal   = {The FASEB Journal. 15 (2001)},
  isbn      = {1530-6860},
  pages     = {1711 -- 1717},
  year      = {2001},
  language  = {en}
}
@article{ArtmannTrzewikAtes2002,
  author    = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Ates, M.},
  title     = {A novel method to quantify mechanical tension in cell monolayers. Trzewik, J{\"u}rgen; Ates, M., Artmann, Gerhard Michael},
  series = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1},
  journal   = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1},
  isbn      = {0013-5585},
  pages     = {379 -- 381},
  year      = {2002},
  language  = {en}
}
@article{ArtmannTrzewikSchmidSchoenbein2000,
  author    = {Artmann, Gerhard and Trzewik, J. and Schmid-Sch{\"o}nbein, G. W.},
  title     = {Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Sch{\"o}nbein, G. W.},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {521 -- 522},
  year      = {2000},
  language  = {en}
}
@book{ArtmannTemizArtmannZhubanovaetal.2018,
  author    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  title     = {Biological, physical and technical basics of cell engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7903-0},
  pages     = {xxiv, 481 Seiten ; Illustrationen, Diagramme},
  year      = {2018},
  language  = {en}
}
@article{ArtmannTeitelSchmidSchoenbein1987,
  author    = {Artmann, Gerhard and Teitel, P. and Schmid-Sch{\"o}nbein, H.},
  title     = {Variable rheologische Antwort der Erythrozyten auf den Einfluß von Xantinderivaten (Coffein): Experimentelle Differenzierung von "Responders" und "Nonresponders"},
  series = {11. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation},
  journal   = {11. Jahrestagung der Gesellschaft f{\"u}r Mikrozirkulation},
  publisher = {Karger [u.a.]},
  address   = {Basel [u.a.]},
  pages     = {100 -- 105},
  year      = {1987},
  language  = {de}
}
@article{ArtmannSungHornetal.1997,
  author    = {Artmann, Gerhard and Sung, K.-L. Paul and Horn, Thomas and Whittemore, Darren [u.a.]},
  title     = {Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu},
  series = {Biophysical journal. 72 (1997), H. 3},
  journal   = {Biophysical journal. 72 (1997), H. 3},
  isbn      = {1542-0086},
  pages     = {1434 -- 1441},
  year      = {1997},
  language  = {en}
}
@inproceedings{ArtmannStadlerEmbsetal.2010,
  author    = {Artmann, Gerhard and Stadler, Andreas M. and Embs, Jan P. and Zaccai, Giuseppe and B{\"u}ldt, Georg and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]},
  year      = {2010},
  abstract  = {The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@article{ArtmannStacheKoenigsfeld2000,
  author    = {Artmann, Gerhard and Stache, O. and K{\"o}nigsfeld, J.},
  title     = {Temperaturabh{\"a}ngigkeit der Pseudopodienbildung und R{\"u}ckbildung von Granulozyten / Stache, O. ; K{\"o}nigsfeld, J. ; Artmann, G. M.},
  series = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  journal   = {Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1},
  isbn      = {1862-278X},
  pages     = {450 -- 451},
  year      = {2000},
  language  = {de}
}
@article{ArtmannShiAgostietal.1998,
  author    = {Artmann, Gerhard and Shi, Young de and Agosti, R. and Longhini, E.},
  title     = {A modified casson equation to characterize blood rheology for hypertension. Shi, Young de; Artmann, Gerhard Michael; Agosti, R.; Longhini, E.},
  series = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2},
  journal   = {Clinical Hemorheology Microcirculation. 19 (1998), H. 2},
  isbn      = {1386-0291},
  pages     = {115 -- 127},
  year      = {1998},
  language  = {en}
}
@article{ArtmannSchmidSchoenbeinSchroederetal.1988,
  author    = {Artmann, Gerhard and Schmid-Sch{\"o}nbein, H. and Schr{\"o}der, Susanne and Grebe, R. [u.a.]},
  title     = {Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Sch{\"o}nbein, H.; Schr{\"o}der, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P.},
  series = {Arzneimittelforschung. 38 (1988), H. 5},
  journal   = {Arzneimittelforschung. 38 (1988), H. 5},
  isbn      = {0004-4172},
  pages     = {710 -- 716},
  year      = {1988},
  language  = {en}
}