@article{WiesenTippkoetterMuffleretal.2015,
  author    = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland},
  title     = {Adsorption of fatty acids to layered double hydroxides in aqueous systems},
  series = {Adsorption},
  volume    = {21},
  journal   = {Adsorption},
  number    = {6-7},
  publisher = {Springer},
  address   = {Berlin},
  pages     = {459 -- 466},
  year      = {2015},
  abstract  = {Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L-1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32-.},
  language  = {en}
}
@misc{WiesenTippkoetterMuffleretal.2012,
  author    = {Wiesen, S. and Tippk{\"o}tter, Nils and Muffler, K. and Sohling, U. and Ruf, F. and Ulber, Roland},
  title     = {Nutzung von Rohglycerin: Rohglycerin-Aufarbeitung, Herstellung von 1, 3-Propandiol und R{\"u}ckgewinnung von Fetts{\"a}uren},
  series = {Chemie Ingenieur Technik},
  volume    = {84},
  journal   = {Chemie Ingenieur Technik},
  number    = {8},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201250265},
  pages     = {1296},
  year      = {2012},
  abstract  = {Die fermentative Verwertung von Rohglycerin setzt je nach Herstellungsmethode und Produktionsorganismus eine Vorbehandlung des Glycerins zur Entfernung von Produktinhibitoren voraus. Durch den Einsatz von Hydrotalcit-Adsorbern k{\"o}nnen die im Rohglycerin enthaltenen Fetts{\"a}uren entfernt werden. Durch diese einfache Aufarbeitungsmethode ist ein mit reinem Glycerin vergleichbarer Umsatz von stark mit Fetts{\"a}uren verunreinigtem Rohglycerin zu 1,3-Propandiol (PDO) m{\"o}glich. Die durch den Hydrotalcit gebundenen Fetts{\"a}uren lassen sich mit einem Ethanol-Wasser-Gemisch eluieren. Somit kann der Adsorber regeneriert und die Fetts{\"a}uren wieder der Wertsch{\"o}pfungskette zugef{\"u}hrt werden. Im Fed-Batch-Experiment kann mit C. diolis eine PDO-Konzentration von {\"u}ber 50 g L⁻¹ unter Verwendung des aufgereinigten Rohglycerins erzielt werden. In der industriellen Produktion wird PDO momentan destillativ aufgearbeitet. Ein adsorptives Aufarbeitungsverfahren kann den Energiebedarf des Herstellungsprozesses drastisch senken. Auf der Suche nach einem geeigneten Material wurde ein Adsorberscreening in Bezug auf die Bindungseigenschaften durchgef{\"u}hrt. Mit einem b-Zeolith der Firma S{\"u}d ChemieAG konnte bisher die h{\"o}chste Beladung im Modellsystem von 120 mg PDO/gAdsorber erreicht werden.},
  language  = {de}
}
@misc{WiesenTippkoetterDuweetal.2012,
  author    = {Wiesen, S. and Tippk{\"o}tter, Nils and Duwe, A. and Ulber, Roland},
  title     = {Aceton-Butanol-Ethanol (ABE)-Fermentation von Organosolv-Holzhydrolysaten},
  series = {Chemie Ingenieur Technik},
  volume    = {84},
  journal   = {Chemie Ingenieur Technik},
  number    = {8},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201250262},
  pages     = {1308},
  year      = {2012},
  abstract  = {Die L{\"o}sungsmittelherstellung durch Clostridien konnte wirtschaftlich nicht mit der chemischen Synthese von L{\"o}sungsmitteln auf Erd{\"o}lbasis konkurrieren und wurde in den fr{\"u}hen 1960er Jahren nahezu vollst{\"a}ndig eingestellt. Das Interesse an nachwachsenden Rohstoffen hat in den letzten Jahren zu einem Wiederaufleben der ABE-Fermentation gef{\"u}hrt. Aufgrund seiner h{\"o}heren Energiedichte im Vergleich zu Ethanol ist Biobutanol als Energietr{\"a}gerbesonders interessant und bietet sich z. B. als Produkt einer Bioraffinerie der 2. Generation an. F{\"u}r die beschriebenen Experimente wird durch das Organosolv-Verfahren aufgeschlossenes Buchenholz verwendet. Der Faserstoff wird mithilfe von CTec2-Enzymen hydrolysiert, wobei der erhaltene {\"U}berstand eine Glucosekonzentration von 66 g L⁻¹ aufweist. Auf der Basis dieses Materials k{\"o}nnen mit Clostridium acetobutylicum Butanol-Ausbeuten erzielt werden, die mit denen unter Verwendung von reinen Zuckern vergleichbar sind. Dem Problem der hohen Produktinhibierung wird mit einer In-situ-Produktaufarbeitung begegnet. Mithilfe von L{\"o}sungsmittelimpr{\"a}gnierten Partikeln (SIPs) kann die Produktausbeute drastisch gesteigert werden, indem die gebildeten L{\"o}sungsmittel durch das auf dem Partikel impr{\"a}gnierte L{\"o}sungsmittel w{\"a}hrend der Fermentation extrahiert werden. Zudem wird hierdurch die weitere Produktaufarbeitungstark vereinfacht.},
  language  = {de}
}
@misc{WielandSiegertSpitzetal.2011,
  author    = {Wieland, Susanne and Siegert, Petra and Spitz, Astrid and Maurer, Karl-Heinz and O'Connell, Timothy and Pr{\"u}ser, Inken and Schiedel, Marc-Steffen and Eiting, Thomas and Sendor-M{\"u}ller, Dorota and Bastigkeit, Thorsten and Benda, Konstantin and M{\"u}ller, Sven},
  title     = {Lagerstabiles fl{\"u}ssiges Wasch- oder Reinigungsmittel enthaltend Proteasen [Offenlegungsschrift]},
  publisher = {Deutsches Patent- und Markenamt / Europ{\"a}isches Patentamt / WIPO},
  address   = {M{\"u}nchen / Den Hague / Genf},
  pages     = {1 -- 25},
  year      = {2011},
  language  = {de}
}
@article{WiegandVoigtAlbrechtetal.2013,
  author    = {Wiegand, Sandra and Voigt, Birgit and Albrecht, Dirk and Bongaerts, Johannes and Evers, Stefan and Hecker, Michael and Daniel, Rolf and Liesegang, Heiko},
  title     = {Fermentation stage-dependent adaptations of Bacillus licheniformis during enzyme production},
  series = {Microbial Cell Factories},
  volume    = {12},
  journal   = {Microbial Cell Factories},
  publisher = {Biomed Central},
  address   = {London},
  issn      = {1475-2859},
  doi       = {10.1186/1475-2859-12-120},
  pages     = {120},
  year      = {2013},
  language  = {en}
}
@article{WiegandDietrichHerteletal.2013,
  author    = {Wiegand, Sandra and Dietrich, Sascha and Hertel, Robert and Bongaerts, Johannes and Evers, Stefan and Volland, Sonja and Daniel, Rolf and Liesegang, Heiko},
  title     = {RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation},
  series = {BMC genomics},
  volume    = {Vol. 14},
  journal   = {BMC genomics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1471-2164},
  pages     = {667},
  year      = {2013},
  language  = {en}
}
@article{WhiteheadOehlschlaegerAlmajhdietal.2014,
  author    = {Whitehead, Mark and {\"O}hlschl{\"a}ger, Peter and Almajhdi, Fahad N. and Alloza, Leonor and Marz{\´a}bal, Pablo and Meyers, Ann E. and Hitzeroth, Inga I. and Rybicki, Edward P.},
  title     = {Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice},
  series = {BMC cancer},
  journal   = {BMC cancer},
  number    = {14:367},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1471-2407},
  doi       = {10.1186/1471-2407-14-367},
  pages     = {1 -- 15},
  year      = {2014},
  language  = {en}
}
@article{WernerKrumbeSchumacheretal.2011,
  author    = {Werner, Frederik and Krumbe, Christoph and Schumacher, Katharina and Groebel, Simone and Spelthahn, Heiko and Stellberg, Michael and Wagner, Torsten and Yoshinobu, Tatsuo and Selmer, Thorsten and Keusgen, Michael and Baumann, Marcus and Sch{\"o}ning, Michael Josef},
  title     = {Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor},
  series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6},
  journal   = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6},
  publisher = {Wiley},
  address   = {Weinheim},
  isbn      = {1862-6319},
  pages     = {1340 -- 1344},
  year      = {2011},
  language  = {en}
}
@article{WernerGroebelWagneretal.2011,
  author    = {Werner, Frederik and Groebel, Simone and Wagner, Torsten and Yoshinobu, Tatsuo and Selmer, Thorsten and Baumann, Marcus and Sch{\"o}ning, Michael Josef},
  title     = {{\"U}berwachung der metabolischen Aktivit{\"a}t von Mikroorganismen zur Kontrolle des biologischen Prozesses im Biogasfermenter},
  series = {Biogas 2011 : Energietr{\"a}ger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt},
  journal   = {Biogas 2011 : Energietr{\"a}ger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt},
  publisher = {VDI-Verl.},
  address   = {D{\"u}sseldorf},
  isbn      = {978-3-18-092121-1},
  pages     = {285 -- 286},
  year      = {2011},
  language  = {de}
}
@article{WernerGroebelSchuhmacheretal.2009,
  author    = {Werner, Frederik and Groebel, Simone and Schuhmacher, K. and Spelthahn, Heiko and Wagner, Torsten and Selmer, Thorsten and Baumann, Marcus and Sch{\"o}ning, Michael Josef},
  title     = {Bestimmung der metabolischen Aktivit{\"a}t von Mikroorganismen w{\"a}hrend des Biogasbildungsprozesses},
  series = {9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.]},
  journal   = {9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.]},
  publisher = {TUDpress},
  address   = {Dresden},
  isbn      = {978-3-941298-44-6},
  pages     = {201 -- 204},
  year      = {2009},
  language  = {de}
}
@article{WernerGroebelKrumbeetal.2012,
  author    = {Werner, Frederik and Groebel, Simone and Krumbe, Christoph and Wagner, Torsten and Selmer, Thorsten and Yoshinobu, Tatsuo and Baumann, Marcus and Sch{\"o}ning, Michael Josef},
  title     = {Nutrient concentration-sensitive microorganism-based biosensor},
  series = {Physica Status Solidi (a)},
  volume    = {209},
  journal   = {Physica Status Solidi (a)},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201100801},
  pages     = {900 -- 904},
  year      = {2012},
  language  = {en}
}
@article{WerkhausenAlbrachtCroninetal.2017,
  author    = {Werkhausen, Amelie and Albracht, Kirsten and Cronin, Neil J. and Meier, Rahel and Mojsen-Moeller, Jens and Seynnes, Olivier R.},
  title     = {Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task},
  series = {Journal of Experimental Biology},
  volume    = {220},
  journal   = {Journal of Experimental Biology},
  number    = {22},
  issn      = {0022-0949},
  doi       = {10.1242/jeb.164111},
  pages     = {4141 -- 4149},
  year      = {2017},
  language  = {en}
}
@incollection{WendorffEggertPohletal.2007,
  author    = {Wendorff, Marion and Eggert, Thorsten and Pohl, Martina and Dresen, Carola and M{\"u}ller, Michael and Jaeger, Karl-Erich and Sprenger, Georg A. and Sch{\"u}rmann, Melanie and Sch{\"u}rmann, Martin and Johnen, Sandra and Sprenger, Gerda and Sahm, Hermann and Inoue, Tomoyuki and Sch{\"o}rken, Ulrich and Breittaupt, Holger and Fr{\"o}lich, Bettina and Heim, Petra and Iding, Hans and Juchem, Bettina and Siegert, Petra and Kula, Maria-Regina and Weckbecker, Andrea and Hummel, Werner and Fessner, Wolf-Dieter and Elling, Lothar and Wolberg, Michael and Bode, Silke and Feldmann, Ralf and Geilenkirchen, Petra and Schubert, Thomas and Walter, Lydia and D{\"u}nnwald, Thomas and Demir, Ayhan S. and Kolter-Jung, Doris and Nitsche, Adam and D{\"u}nkelmann, Pascal and Cosp, Annabel and Lingen, Bettina},
  title     = {Catalytic asymmetric synthesis : section 2.2},
  series = {Asymmetric synthesis with chemical and biological methods / ed. by Dieter Enders ...},
  booktitle = {Asymmetric synthesis with chemical and biological methods / ed. by Dieter Enders ...},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  isbn      = {978-3-527-31473-7},
  pages     = {298 -- 413},
  year      = {2007},
  language  = {en}
}
@article{WeldenJablonskiWegeetal.2021,
  author    = {Welden, Rene and Jablonski, Melanie and Wege, Christina and Keusgen, Michael and Wagner, Patrick Hermann and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase},
  series = {Biosensors},
  volume    = {11},
  journal   = {Biosensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-6374},
  doi       = {10.3390/bios11060171},
  pages     = {Artikel 171},
  year      = {2021},
  abstract  = {The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte's pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS.},
  language  = {en}
}
@article{WeldenSeverinsPoghossianetal.2022,
  author    = {Welden, Melanie and Severins, Robin and Poghossian, Arshak and Wege, Christina and Bongaerts, Johannes and Siegert, Petra and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor},
  series = {Chemosensors},
  volume    = {10},
  journal   = {Chemosensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2227-9040},
  doi       = {10.3390/chemosensors10060218},
  pages     = {Artikel 218},
  year      = {2022},
  abstract  = {Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte-insulator-semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin-streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage-current, capacitance-voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution.},
  language  = {en}
}
@article{WeldenPoghossianVahidpouretal.2022,
  author    = {Welden, Melanie and Poghossian, Arshak and Vahidpour, Farnoosh and Wendlandt, Tim and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers},
  series = {Biosensors},
  volume    = {12},
  journal   = {Biosensors},
  number    = {1},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-6374},
  doi       = {10.3390/bios12010043},
  pages     = {Artikel 43},
  year      = {2022},
  abstract  = {Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1-3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.},
  language  = {en}
}
@article{WardoyoNoorElbersetal.2020,
  author    = {Wardoyo, Arinto Y.P. and Noor, Johan A.E. and Elbers, Gereon and Schmitz, Sandra and Flaig, Sascha T. and Budianto, Arif},
  title     = {Characterizing volcanic ash elements from the 2015 eruptions of bromo and raung volcanoes, Indonesia},
  series = {Polish Journal of Environmental Studies},
  volume    = {29},
  journal   = {Polish Journal of Environmental Studies},
  number    = {2},
  publisher = {HARD},
  address   = {Olsztyn},
  issn      = {2083-5906},
  doi       = {10.15244/pjoes/99101},
  pages     = {1899 -- 1907},
  year      = {2020},
  abstract  = {The volcanic eruptions of Mt. Bromo and Mt. Raung in East Java, Indonesia, in 2015 perturbed volcanic materials and affected surface-layer air quality at surrounding locations. During the episodes, the volcanic ash from the eruptions influenced visibility, traffic accidents, flight schedules, and human health. In this research, the volcanic ash particles were collected and characterized by relying on the detail of physical observation. We performed an assessment of the volcanic ash elements to characterize the volcanic ash using two different methods which are aqua regia extracts followed by MP-AES and XRF laboratory test of bulk samples. The analysis results showed that the volcanic ash was mixed of many materials, such as Al, Si, P, K, Ca, Ti, V, Cr, Mn, Fe, Ni, and others. Fe, Si, Ca, and Al were found as the major elements, while the others were the trace elements Ba, Cr, Cu, Mn, P, Mn, Ni, Zn, Sb, Sr, and V with the minor concentrations. XRF analyses showed that Fe dominated the elements of the volcanic ash. The XRF analysis showed that Fe was at 35.40\% in Bromo and 43.00\% in Raung of the detected elements in bulk material. The results of aqua regia extracts analyzed by MP-AES were 1.80\% and 1.70\% of Fe element for Bromo and Raung volcanoes, respectively.},
  language  = {en}
}
@article{WangDruckenmuellerElbersetal.2014,
  author    = {Wang, Ren-Qi and Druckenm{\"u}ller, Katharina and Elbers, Gereon and Guenther, Klaus and Crou{\´e}, Jean-Philippe},
  title     = {Analysis of aquatic-phase natural organic matter by optimized LDI-MS method},
  series = {Journal of mass spectrometry},
  volume    = {49},
  journal   = {Journal of mass spectrometry},
  number    = {2},
  publisher = {Wiley},
  address   = {Bognor Regis},
  issn      = {1096-9888},
  doi       = {10.1002/jms.3321},
  pages     = {154 -- 160},
  year      = {2014},
  abstract  = {The composition and physiochemical properties of aquatic-phase natural organic matter (NOM) are most important problems for both environmental studies and water industry. Laser desorption/ionization (LDI) mass spectrometry facilitated successful examinations of NOM, as humic and fulvic acids in NOM are readily ionized by the nitrogen laser. In this study, hydrophobic NOMs (HPO NOMs) from river, reservoir and waste water were characterized by this technique. The effect of analytical variables like concentration, solvent composition and laser energy was investigated. The exact masses of small molecular NOM moieties in the range of 200-1200 m/z were determined in reflectron mode. In addition, spectra of post-source-decay experiments in this range showed that some compounds from different natural NOMs had the same fragmental ions. In the large mass range of 1200-15 000 Da, macromolecules and their aggregates were found in HPO NOMs from natural waters. Highly humic HPO exhibited mass peaks larger than 8000 Da. On the other hand, the waste water and reservoir water mainly had relatively smaller molecules of about 2000 Da. The LDI-MS measurements indicated that highly humic river waters were able to form large aggregates and membrane foulants, while the HPO NOMs from waste water and reservoir water were unlikely to form large aggregates. Copyright © 2014 John Wiley \& Sons, Ltd.},
  language  = {en}
}
@article{WallerBraunHojdisetal.2007,
  author    = {Waller, Mark P. and Braun, Heiko and Hojdis, Nils and B{\"u}hl, Michael},
  title     = {Geometries of Second-Row Transition-Metal Complexes from Density-Functional Theory},
  series = {Journal of Chemical Theory and Computation},
  volume    = {3},
  journal   = {Journal of Chemical Theory and Computation},
  number    = {6},
  issn      = {1549-9626},
  doi       = {10.1021/ct700178y},
  pages     = {2234 -- 2242},
  year      = {2007},
  language  = {en}
}
@article{WagnerMolinaYoshinobuetal.2007,
  author    = {Wagner, Torsten and Molina, Roberto and Yoshinobu, Tatsuo and Kloock, Joachim P. and Biselli, Manfred and Canzoneri, Michele and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef},
  title     = {Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications},
  series = {Electrochimica Acta. 53 (2007), H. 2},
  journal   = {Electrochimica Acta. 53 (2007), H. 2},
  isbn      = {0013-4686},
  pages     = {305 -- 311},
  year      = {2007},
  language  = {en}
}
@article{WagnerMolinaBisellietal.2007,
  author    = {Wagner, Torsten and Molina, R. and Biselli, Manfred and Canzoneri, Michele and Schnitzler, Thomas and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells},
  series = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)},
  journal   = {Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.)},
  publisher = {IEEE},
  address   = {Piscataway},
  isbn      = {1-4244-0841-5},
  pages     = {1107 -- 1110},
  year      = {2007},
  language  = {en}
}
@article{WagnerBegingRotteretal.2007,
  author    = {Wagner, Torsten and Beging, Stefan and Rotter, L. and Poghossian, Arshak and Biselli, Manfred and Zang, Werner and Sch{\"o}ning, Michael Josef},
  title     = {Online-Messsysteme f{\"u}r die automatisierte Charakterisierung von feldeffektbasierten Biosensoren},
  series = {8. Dresdner Sensor-Symposium : Sensoren f{\"u}r Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme f{\"u}r die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung f{\"u}r die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)},
  journal   = {8. Dresdner Sensor-Symposium : Sensoren f{\"u}r Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme f{\"u}r die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung f{\"u}r die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.)},
  publisher = {TUDpress, Verl. der Wissenschaften},
  address   = {Dresden},
  isbn      = {978-3-940046-45-1},
  pages     = {257 -- 260},
  year      = {2007},
  language  = {de}
}
@book{WagemannTippkoetter2019,
  author    = {Wagemann, Kurt and Tippk{\"o}tter, Nils},
  title     = {Biorefineries / Kurt Wagemann, Nils Tippk{\"o}tter (editors)},
  series = {Advances in biochemical engineering/biotechnology book series (ABE)},
  journal   = {Advances in biochemical engineering/biotechnology book series (ABE)},
  publisher = {Springer},
  address   = {Cham (Switzerland)},
  isbn      = {978-3-319-97117-9},
  doi       = {10.1007/978-3-319-97119-3},
  pages     = {VI, 549 Seiten},
  year      = {2019},
  language  = {en}
}
@incollection{WagemannTippkoetter2018,
  author    = {Wagemann, Kurt and Tippk{\"o}tter, Nils},
  title     = {Biorefineries: a short introduction},
  series = {Biorefineries},
  booktitle = {Biorefineries},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-97117-9},
  doi       = {10.1007/10_2017_4},
  pages     = {1 -- 11},
  year      = {2018},
  abstract  = {The terms bioeconomy and biorefineries are used for a variety of processes and developments. This short introduction is intended to provide a delimitation and clarification of the terminology as well as a classification of current biorefinery concepts. The basic process diagrams of the most important biorefinery types are shown.},
  language  = {en}
}
@article{WackwitzBongaertsGoodmanetal.1999,
  author    = {Wackwitz, B. and Bongaerts, Johannes and Goodman, S. D. and Unden, Gottfried},
  title     = {Growth phase-dependent regulation of nuoA-N expression in Escherichia coli K-12 by the Fis protein: upstream binding sites and bioenergetic significance},
  series = {Molecular and general genetics : MGG},
  volume    = {Vol. 262},
  journal   = {Molecular and general genetics : MGG},
  number    = {Iss. 4 - 5},
  issn      = {1617-4623 (E-Journal); 1617-4615 (Print)},
  pages     = {876 -- 883},
  year      = {1999},
  language  = {en}
}
@article{VoigtSchroeterJuergenetal.2013,
  author    = {Voigt, Birgit and Schroeter, Rebecca and J{\"u}rgen, Britta and Albrecht, Dirk and Evers, Stefan and Bongaerts, Johannes and Maurer, Karl-Heinz and Schweder, Thomas and Hecker, Michael},
  title     = {The response of Bacillus licheniformis to heat and ethanol stress and the role of the SigB regulon},
  series = {Proteomics},
  volume    = {Vol. 13},
  journal   = {Proteomics},
  number    = {Iss. 14},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1615-9861 (E-Journal); 1615-9853 (Print)},
  pages     = {2140 -- 2146},
  year      = {2013},
  language  = {en}
}
@article{VoigtAlbrechtSieversetal.2015,
  author    = {Voigt, Birgit and Albrecht, Dirk and Sievers, Susanne and Becher, D{\"o}rte and Bongaerts, Johannes and Evers, Stefan and Schweder, Thomas and Maurer, Karl-Heinz and Hecker, Michael},
  title     = {High-resolution proteome maps of Bacillus licheniformis cells growing in minimal medium},
  series = {Proteomics},
  volume    = {15},
  journal   = {Proteomics},
  number    = {15},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1615-9861},
  doi       = {10.1002/pmic.201400504},
  pages     = {2629 -- 2633},
  year      = {2015},
  language  = {en}
}
@misc{VarrialeKukaTippkoetteretal.2022,
  author    = {Varriale, Ludovica and Kuka, Katrin and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Use of a green biomass in a biorefinery platform},
  series = {Chemie Ingenieur Technik},
  volume    = {94},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.202255095},
  pages     = {1299},
  year      = {2022},
  abstract  = {The emerging environmental issues due to the use of fossil resources are encouraging the exploration of new renewable resources. Biomasses are attracting more interest due to the low environmental impacts, low costs, and high availability on earth. In this scenario, green biorefineries are a promising platform in which green biomasses are used as feedstock. Grasses are mainly composed of cellulose and hemicellulose, and lignin is available in a small amount. In this work, a perennial ryegrass was used as feedstock to develop a green bio-refinery platform. Firstly, the grass was mechanically pretreated, thus obtaining a press juice and a press cake fraction. The press juice has high nutritional values and can be employed as part of fermentation media. The press cake can be employed as a substrate either in enzymatic hydrolysis or in solid-state fermentation. The overall aim of this work was to demonstrate different applications of both the liquid and the solid fractions. For this purpose, the filamentous fungus A. niger and the yeast Y. lipolythica were selected for their ability to produce citric acid. Finally, the possibility was assessed to use the press juice as part of fermentation media to cultivate S. cerevisiae and lactic acid bacteria for ethanol and lactic acid fermentation.},
  language  = {en}
}
@techreport{VaessenOhmeManderscheid2012,
  author    = {Vaeßen, Christiane and Ohme, H. and Manderscheid, D.},
  title     = {Endbericht Projekt Immotherm : Vorhabensbezeichnung: KMU-innovativ-Verbundvorhaben "Einsatz immobilisierter Mikroorganismen zur Ent{\"o}lung und Entsalzung von Kondensatwasser bei hohen Prozesstemperaturen" : Laufzeit des Vorhabens: 01.03.2009-31.08.2011 : F{\"o}rderkennzeichen: 01LY0816A, 01LY0816B, 01LY0816C},
  pages     = {71 S. : zahlr. Ill. u. graph. Darst.},
  year      = {2012},
  language  = {de}
}
@article{UndenBongaerts1997,
  author    = {Unden, Gottfried and Bongaerts, Johannes},
  title     = {Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors},
  series = {Biochimica et biophysica acta (BBA) - Bioenergetics},
  volume    = {Vol. 1320},
  journal   = {Biochimica et biophysica acta (BBA) - Bioenergetics},
  number    = {Iss. 3},
  issn      = {1879-2650 (E-Journal); 0005-2728 (Print)},
  pages     = {217 -- 234},
  year      = {1997},
  language  = {en}
}
@article{UndenBeckerBongaertsetal.1994,
  author    = {Unden, G. and Becker, S. and Bongaerts, Johannes and Schirawski, J. and Six, S.},
  title     = {Oxygen regulated gene expression in facultatively anaerobic bacteria},
  series = {Antonie van Leeuwenhoek},
  volume    = {Vol. 66},
  journal   = {Antonie van Leeuwenhoek},
  number    = {Iss. 1-3},
  issn      = {0003-6072 (Print) ; 1572-9699 (online)},
  pages     = {3 -- 22},
  year      = {1994},
  language  = {en}
}
@article{UndenBeckerBongaertsetal.1995,
  author    = {Unden, G. and Becker, S. and Bongaerts, Johannes and Holighaus, G. and Schirawski, J. and Six, S.},
  title     = {O2-sensing and O2-dependent gene regulation in facultatively anaerobic bacteria},
  series = {Archives of microbiology},
  volume    = {Vol. 164},
  journal   = {Archives of microbiology},
  number    = {Iss. 2},
  issn      = {1432-072X (E-Journal); 0003-9276 (Print); 0302-8933 (Print)},
  pages     = {81 -- 90},
  year      = {1995},
  language  = {en}
}
@article{UlberTippkoetterBuchholzetal.2008,
  author    = {Ulber, Roland and Tippk{\"o}tter, Nils and Buchholz, H. and Demmer, W. and Scheper, T.},
  title     = {Innovative Verfahren in der Molkeaufarbeitung zur Gewinnung neuer Produkte},
  series = {Deutsche Milchwirtschaft},
  volume    = {59},
  journal   = {Deutsche Milchwirtschaft},
  number    = {19},
  issn      = {0012-0480},
  pages     = {704 -- 706},
  year      = {2008},
  language  = {de}
}
@article{UlberTippkoetter2009,
  author    = {Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Nitratfreie Molke},
  series = {Rundschau f{\"u}r Fleischhygiene und Lebensmittel{\"u}berwachung},
  journal   = {Rundschau f{\"u}r Fleischhygiene und Lebensmittel{\"u}berwachung},
  number    = {4},
  pages     = {150 -- 152},
  year      = {2009},
  language  = {de}
}
@article{UlberPothMonzonetal.2010,
  author    = {Ulber, Roland and Poth, Sebastian and Monzon, Magaly and Tippk{\"o}tter, Nils},
  title     = {Prozessintegration von Hydrolyse und Fermentation von Cellulose- Faserstoff},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {1-2},
  issn      = {1522-2640},
  doi       = {10.1002/cite.200900103},
  pages     = {135 -- 139},
  year      = {2010},
  abstract  = {Ein viel versprechender erneuerbarer Rohstoff f{\"u}r die Produktion von Chemikalien und Treibstoffen ist Lignocellulose aus pflanzlicher Biomasse. Die darin enthaltenen Zucker k{\"o}nnen mittels enzymatischer Hydrolyse freigesetzt und fermentativ zu Ethanol umgesetzt werden. Ein interessanter Ansatz ist dabei die simultane Verzuckerung und Fermentation. Hefen und Enzyme haben mit 30 °C bzw. 50 °C zwar unterschiedliche Temperaturoptima, es konnte aber gezeigt werden, dass auch bei den niedrigeren Temperaturen eine Umsetzung der Cellulose zu Glucose erfolgt, wenn auch langsamer als bei optimalen Bedingungen. Außerdem konnte in Vorversuchen gezeigt werden, dass Ethanol in den zu erwartenden Konzentrationen keinen Einfluss auf die enzymatische Umsetzung hat.},
  language  = {de}
}
@incollection{UlberMufflerTippkoetteretal.2011,
  author    = {Ulber, Roland and Muffler, Kai and Tippk{\"o}tter, Nils and Hirth, Thomas and Sell, Dieter},
  title     = {Introduction to Renewable Resources in the Chemical Industry},
  series = {Renewable raw materials : new feedstocks for the chemical industry},
  booktitle = {Renewable raw materials : new feedstocks for the chemical industry},
  editor    = {Ulber, Roland and Sell, Dieter and Hirth, Thomas},
  edition   = {1. Auflage},
  publisher = {Wiley-VCH-Verlag},
  address   = {Weinheim},
  isbn      = {978-3-527-32548-1},
  pages     = {1 -- 6},
  year      = {2011},
  language  = {de}
}
@article{TuegBaumann1994,
  author    = {T{\"u}g, Helmut and Baumann, Marcus},
  title     = {Problems of UV-B radiation measurements in biological research : critical remarks on current techniques and suggestions for improvements},
  series = {Geophysical research letters},
  volume    = {Vol. 21},
  journal   = {Geophysical research letters},
  number    = {Iss. 8},
  issn      = {1944-8007 (E-Journal); 0094-8276 (Print)},
  pages     = {689 -- 692},
  year      = {1994},
  language  = {en}
}
@article{TuegBaumann1995,
  author    = {T{\"u}g, Helmut and Baumann, Marcus},
  title     = {Reply to the comments by R.L. McKenzie and P.V. Johnston on our paper "Problems of UV-B radiation measurements in biological research: Critical Remarks on current techniques and suggestions for improvements"},
  series = {Geophysical research letters},
  volume    = {Vol. 22},
  journal   = {Geophysical research letters},
  number    = {Iss. 9},
  issn      = {1944-8007 (E-Journal); 0094-8276 (Print)},
  pages     = {1159 -- 1160},
  year      = {1995},
  language  = {en}
}
@article{TurekKettererClassenetal.2007,
  author    = {Turek, Monika and Ketterer, Lothar and Claßen, Melanie and Berndt, Heinz and Elbers, Gereon and Kr{\"u}ger, Peter and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Development and Electrochemical Investigations of an EIS-(Electrolyte-Insulator-Semiconductor) based Biosensor for Cyanide Detection},
  series = {Sensors},
  volume    = {7},
  journal   = {Sensors},
  number    = {8},
  isbn      = {1424-8220},
  pages     = {1415 -- 1426},
  year      = {2007},
  language  = {en}
}
@article{TurckBerndt1981,
  author    = {Turck, Christoph W. and Berndt, Heinz},
  title     = {Synthese definierter Peptid-Derivate durch Aminolyse von 3-(Nα-Acyl-peptidyloxy)-2-hydroxy-N-alkylbenzamiden bei erh{\"o}hten Temperaturen, I : Synthese des Modellpeptid-Derivates Z-Ala-Phe-Gly-N(Et)2},
  series = {Hoppe-Seyler´s Zeitschrift f{\"u}r physiologische Chemie},
  volume    = {362},
  journal   = {Hoppe-Seyler´s Zeitschrift f{\"u}r physiologische Chemie},
  number    = {1},
  issn      = {1437-4315},
  doi       = {10.1515/bchm2.1981.362.1.821},
  pages     = {821 -- 828},
  year      = {1981},
  language  = {de}
}
@article{TrappLammersEngudaretal.2023,
  author    = {Trapp, Svenja and Lammers, Tom and Engudar, Gokce and Hoehr, Cornelia and Denkova, Antonia G. and Paulßen, Elisabeth and de Kruijff, Robin M.},
  title     = {Membrane-based microfluidic solvent extraction of Ga-68 from aqueous Zn solutions: towards an automated cyclotron production loop},
  series = {EJNMMI Radiopharmacy and Chemistry},
  volume    = {2023},
  journal   = {EJNMMI Radiopharmacy and Chemistry},
  number    = {8, Article number: 9},
  publisher = {Springer Nature},
  issn      = {2365-421X},
  doi       = {10.1186/s41181-023-00195-2},
  pages     = {1 -- 14},
  year      = {2023},
  language  = {en}
}
@article{TranBongaertsVladetal.1997,
  author    = {Tran, Quang Hon and Bongaerts, Johannes and Vlad, Dorina and Unden, Gottfried},
  title     = {Requirement for the proton-pumping NADH dehydrogenase I of Escherichia coli in respiration of NADH to fumarate and its bioenergetic implications},
  series = {European journal of biochemistry},
  volume    = {Vol. 244},
  journal   = {European journal of biochemistry},
  number    = {Iss. 1},
  issn      = {0014-2956},
  pages     = {155 -- 160},
  year      = {1997},
  language  = {en}
}
@article{TixMollKrafftetal.2024,
  author    = {Tix, Julian and Moll, Fabian and Krafft, Simone and Betsch, Matthias and Tippk{\"o}tter, Nils},
  title     = {Hydrogen production from enzymatic pretreated organic waste with thermotoga neapolitana},
  series = {Energies},
  volume    = {17},
  journal   = {Energies},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1996-1073},
  doi       = {10.3390/en17122938},
  pages     = {20 Seiten},
  year      = {2024},
  abstract  = {Biomass from various types of organic waste was tested for possible use in hydrogen production. The composition consisted of lignified samples, green waste, and kitchen scraps such as fruit and vegetable peels and leftover food. For this purpose, the enzymatic pretreatment of organic waste with a combination of five different hydrolytic enzymes (cellulase, amylase, glucoamylase, pectinase and xylase) was investigated to determine its ability to produce hydrogen (H2) with the hydrolyzate produced here. In course, the anaerobic rod-shaped bacterium T. neapolitana was used for H2 production. First, the enzymes were investigated using different substrates in preliminary experiments. Subsequently, hydrolyses were carried out using different types of organic waste. In the hydrolysis carried out here for 48 h, an increase in glucose concentration of 481\% was measured for waste loads containing starch, corresponding to a glucose concentration at the end of hydrolysis of 7.5 g·L-1. In the subsequent set fermentation in serum bottles, a H2 yield of 1.26 mmol H2 was obtained in the overhead space when Terrific Broth Medium with glucose and yeast extract (TBGY medium) was used. When hydrolyzed organic waste was used, even a H2 yield of 1.37 mmol could be achieved in the overhead space. In addition, a dedicated reactor system for the anaerobic fermentation of T. neapolitana to produce H2 was developed. The bioreactor developed here can ferment anaerobically with a very low loss of produced gas. Here, after 24 h, a hydrogen concentration of 83\% could be measured in the overhead space.},
  language  = {en}
}
@misc{TippkoetterZhangPothetal.2010,
  author    = {Tippk{\"o}tter, Nils and Zhang, M. and Poth, S. and Ulber, Roland},
  title     = {Enzymatische Lignindegradierung unter Einsatz eines Optimierungsalgorithmus},
  series = {Chemie Ingenieur Technik},
  volume    = {82},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201050707},
  pages     = {1601 -- 1602},
  year      = {2010},
  abstract  = {Lignine bestehen aus einem hochgradig vernetzten Polymer phenolischer Grundeinheiten. Diese Verbindungen sind eine Quelle vielversprechender chemischer Grundbausteine. Auch die enzymatische Modifikation der Materialeigenschaften des Lignins ist f{\"u}r dessen Anwendung von Interesse. Aufgrund der verschiedenen Bindungstypen im Lignin ist eine Auftrennung mit nur einem Enzym unwahrscheinlich. Vielmehr sind verschiedene mediatorgest{\"u}tzte Reaktionen notwendig. Pilze, wie z.B. T. versicolor, nutzen Enzymkombinationen zum Aufschluss des Lignins. Hierbei kommen Laccase, Ligninperoxidase und Manganperoxidase zum Einsatz. Die optimale Kombination der Enzyme und ihrer Mediatoren bzw. Stabilisatoren ist Ziel der Untersuchungen. Aufgrund der großen Parameteranzahl wurde ein genetischer Algorithmus eingesetzt. Als Versuchsparameter wurden gew{\"a}hlt: die Verh{\"a}ltnisse der Enzyme, Ligninmasse, Konzentrationen an Eisen-, Mangan-, Oxalat-Ionen, ABTS, Violurs{\"a}ure und H₂O₂. Somit werden elf Parameter simultan optimiert. Als Algorithmus wurde ein Programm mit variabler Genkodierung entwickelt. Die Umsetzung des Lignins wird dabei {\"u}ber den verfolgt. Zurzeit ist ein enzymatischer Umsatz von 12\% m{\"o}glich. Als Referenz wurde eine chemische Lignindegradierung mit einem Umsatzvon 37\% etabliert. Die sechs Generationen des Algorithmus zeigen eine Kongruenz der Enzymkonzentrationen von LiP, MnP und VeP, w{\"a}hrend Laccase keinen Einfluss hat. Des Weiteren beeinflussen die Konzentrationen von Mangan und Oxalat die Umsetzung, w{\"a}hrend die Variation von ABTS- und H₂O₂ nur eine geringe Auswirkung hat.},
  language  = {de}
}
@misc{TippkoetterWulfhorstMogueetal.2014,
  author    = {Tippk{\"o}tter, Nils and Wulfhorst, H. and Mogue, N. and M{\"o}hring, S. and Roth, J. and Ulber, Roland},
  title     = {Spektrometrische Messung und Modellierung der enzymatischen Hydrolyse von Biomasse nach Organosolv- und Liquid Hot Water-Aufschl{\"u}ssen (LHW)},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450269},
  pages     = {1584},
  year      = {2014},
  abstract  = {In diesem Beitrag wird die NIR- und MIR-Spektrometrie in Kombination mit multivariaten Kalibrationsmodellen zur Analyse von Monosacchariden und Cellulose aus Biomasse etabliert. Spektrengemischter Standardl{\"o}sungen mit definierten Glucose- und Xylosekonzentrationen in Wasser werden im NIR-(Lambda 750, Perkin Elmer, USA) und MIR-Bereich (Spektrum 100, PerkinElmer) in Gegenwart von entweder Carboxymethylcellulose oder Grasfasern aufgenommen. Darauf basierend werden Kalibrationsmodelle (Unscrambler®, CAMO-Software AS, Norwegen) entwickelt und zur Vorhersage der Zuckerkonzentration in den Hydrolyseproben und der Celluloseanteile angewendet. Dar{\"u}ber hinaus wird die Partikelgr{\"o}ße der Rohstoffe bestimmt. Die Messergebnisse bilden die experimentelle Basis f{\"u}r die numerische Modellierung der Reaktionskinetik der enzymatischen Hydrolyse von Lignocellulose. Das Modell kombiniert die Bilanzierung der Partikelgr{\"o}ßenverteilungen mit der Multienzymkinetik. Dabei werden neben der Partikelgr{\"o}ßenverteilung und der Substratkonzentration die Zusammensetzung der Rohstoffe nach Vorbehandlung sowie die Produktinhibierung und mehrere enzymatische Aktivit{\"a}ten ber{\"u}cksichtigt. Das Modell erm{\"o}glicht es, die Partikelgr{\"o}ßenverteilungen und die Konzentrationen der Substrate und Produkte w{\"a}hrend der Hydrolyse vorherzusagen und die kinetischen Parameter im Batch- sowie im Fed-Batch-Reaktor zu bestimmen.},
  language  = {de}
}
@article{TippkoetterWollnySucketal.2014,
  author    = {Tippk{\"o}tter, Nils and Wollny, Steffen and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland},
  title     = {Recycling of spent oil bleaching earth as source of glycerol for the anaerobic production of acetone, butanol, and ethanol with Clostridium diolis and lipolytic Clostridium lundense},
  series = {Engineering in Life Sciences},
  volume    = {14},
  journal   = {Engineering in Life Sciences},
  number    = {4},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1618-2863},
  doi       = {10.1002/elsc.201300113},
  pages     = {425 -- 432},
  year      = {2014},
  abstract  = {A major part of edible oil is subjected to bleaching procedures, primarily with minerals applied as adsorbers. Their recycling is currently done either by regaining the oil via organic solvent extraction or by using the spent bleaching earth (SBE) as additive for animal feed, etc. As a new method, the reutilization of the by-product SBE for the microbiologic formation of acetone, butanol, and ethanol (ABE) is presented as proof-of-concept. The SBE was taken from a palm oil cleaning process. The recycling concept is based on the application of lipolytic clostridia strains. Due to considerably long fermentation times, co-fermentation with Candida rugosa and enzymatic hydrolyses of the bound oil with a subsequent clostridia fermentation are shown as alternative routes. Anaerobic fermentations under comparison of different clostridia strains were performed with glycerol media, enzymatically hydrolyzed palm oil and SBE. Solutes, side product compositions and productivities were quantified via HPLC. A successful production of ABE solutes from SBE has been done with a yield of 0.15 g butanol per gram of bound glycerol. Thus, the biotechnological recycling of the waste stream is possible in principle. Inhibition of the substrate suspension has been observed. A chromatographic ion-exchange of substrates increased the biomass concentration.},
  language  = {en}
}
@article{TippkoetterWollnyKampeisetal.2011,
  author    = {Tippk{\"o}tter, Nils and Wollny, S. and Kampeis, P. and Oster, J. and Schneider, H. and Ulber, Roland},
  title     = {Magnetseparation von Proteinen : Separation von Zielmolek{\"u}len durch hochselektive Aptamere},
  series = {GIT Labor-Fachzeitschrift},
  volume    = {55},
  journal   = {GIT Labor-Fachzeitschrift},
  number    = {10},
  publisher = {Wiley},
  address   = {Weinheim},
  pages     = {666},
  year      = {2011},
  abstract  = {Durch die Kombination von Oligonukleotid-Liganden (Aptameren) hoher Bindungsaffinit{\"a}ten mit hochselektiv abtrennbaren magnetisierbaren Mikropartikeln wird eine einstufige Separation von Zielmolek{\"u}len aus mikrobiologischen Produktionsans{\"a}tzen m{\"o}glich. Die Aptamere werden hierf{\"u}r reversibel auf den Partikeloberfl{\"a}chen gebunden und f{\"u}r die spezifische Isolierung von Bioprodukten eingesetzt. Die Abtrennung der beladenen Partikel erfolgt durch einen neuen Rotor-Stator-Separator mit Hochgradient-Magnetfeld.},
  language  = {de}
}
@misc{TippkoetterWiesenThieletal.2014,
  author    = {Tippk{\"o}tter, Nils and Wiesen, S. and Thiel, A. and Muffler, K. and Ulber, Roland},
  title     = {Biotechnologische Wertstoffgewinnung entlang der Prozessketten Gr{\"u}ner und Pflanzen{\"o}l-Bioraffinerien},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450283},
  pages     = {1605},
  year      = {2014},
  abstract  = {Der nachwachsende Rohstoff Raps ist in großen Mengen verf{\"u}gbar und eine Quelle f{\"u}r Biomolek{\"u}le mit hohem Wertsch{\"o}pfungspotenzial. Entwicklungen zur biotechnologischen Wertstoffgewinnung werden dabei schwerpunktm{\"a}ßig in den Bereichen Aufarbeitung und Funktionalisierung von Polyphenolen und Fetten betrieben. Bei der Verarbeitung der Pflanzenmaterialien werden dabei insbesondere Verfahren zur adsorptiven Aufreinigung und Auftrennung mittels Materialien mit modifizierten Bleicherden und anderen organischen oder anorganischen Adsorbentien untersucht. Ferner wurden f{\"u}r die Aufreinigung von Polyphenolen adsorptive sowie extraktive Prozesse entwickelt. Bei den Entwicklungen wird ber{\"u}cksichtigt, dass Bioraffinerien auf eine fortw{\"a}hrende Gew{\"a}hrleistung eines hohen Produktions- bzw. Lieferbedarfs nachwachsender Rohstoffe angewiesen sind. Somit werden Optionen dezentraler regionaler Vorbehandlungs- und Wertsch{\"o}pfungsketten in der N{\"a}he landwirtschaftlicher Betriebe einbezogen. Neben neuen Aufreinigungsverfahren werden mikrobielle und enzymatische Prozesse zur wertsteigernden Umsetzung von Glycerin, Polyphenolen und Zuckermonomeren vorgestellt sowie Limitierungen nachwachsender Rohstoffe der 2. Generation diskutiert.},
  language  = {de}
}
@misc{TippkoetterWasserscheid2014,
  author    = {Tippk{\"o}tter, Nils and Wasserscheid, P.},
  title     = {Rapid-Prototyping-Strukturen f{\"u}r ressourceneffiziente Prozesse in Chemie und Biotechnologie},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450451},
  pages     = {1369 -- 1370},
  year      = {2014},
  abstract  = {Die Teilefertigung durch Rapid Prototyping (RP) verk{\"u}rzt den Weg von der Idee bis zum Produkt, wobei unter anderem Optimierungszyklen in geringer Zeit durchlaufen werden k{\"o}nnen. Ferner er{\"o}ffnen neue Entwicklungen in diesem Bereich die M{\"o}glichkeit individueller Produktionsverfahren. Im Unterschied zur klassischen Fertigung von Prototypen wird beim RP mit additiver Schichtfertigung (Additive Layer Manufacturing, ALM) gearbeitet. Je nach Methode werden Fl{\"u}ssigkeiten oder Pulver nach Vorgaben eines 3D-Computermodells sequentiell aufgetragen. Diese Verfahren existieren seit ca. 25 Jahren, jedoch sind seit kurzem ausgesprochen g{\"u}nstige Ger{\"a}te verf{\"u}gbar, die Objekte mit Genauigkeiten bis 20 lm fertigen k{\"o}nnen. Das RP hat in klinischen Anwendungsgebieten bzw. im Bereich des Tissue Engineering bereits vielfach Einzug gefunden. Aber auch chemisch-biotechnologische Entwicklungen k{\"o}nnen von den Verfahren profitieren. So wurden Mikrofluidiksysteme und Bioreaktoren bereits erfolgreich durch RP gefertigt. Durch ALM ist ebenso die Herstellung von Reaktionseinheiten aus biokompatiblen Materialien wie ionotropen Gelen m{\"o}glich. Ferner sind sehr komplexe Strukturierungen von Oberfl{\"a}chen im Nanometerbereich realisierbar, die f{\"u}r die Auftragung heterogener Katalysatoren oder auch Mikroorganismen eingesetzt werden k{\"o}nnen. Auch der Bereich Reaktoren- und Apparatebau kann von den Fortschritten in der additiven Fertigung profitieren. Verfahren wie selektives Laser- oder Elektronenstrahlschmelzen erlauben es, metallische Komponenten in nahezu beliebigen Geometrien zu fertigen. Somit k{\"o}nnen Strukturen verwirklicht werden, die mit konventionellen Fertigungstechniken nur sehr schwer oder {\"u}berhauptnicht herstellbar w{\"a}ren. Durch Anwendung von rechnergest{\"u}tzter Modellierung k{\"o}nnen optimale Strukturen identifiziert und additiv gefertigt werden. Eine anschließende katalytische Funktionalisierung der Oberfl{\"a}che erm{\"o}glicht die Herstellung strukturierter Reaktoren mit maßgeschneiderten Eigenschaften.},
  language  = {de}
}
@techreport{TippkoetterWagner2019,
  author    = {Tippk{\"o}tter, Nils and Wagner, Sebastian},
  title     = {Biomimetischer Klebstoff aus ligninhaltigen Pflanzenresten (Teilvorhaben 1 und 2) : Schlussbericht zum Vorhaben : Laufzeit: 01.01.2016 bis 31.03.2019},
  publisher = {FH Aachen},
  address   = {J{\"u}lich},
  doi       = {10.2314/KXP:169732777X},
  pages     = {109 S.},
  year      = {2019},
  language  = {de}
}