@inproceedings{BaaderReiswichBartschetal.2018,
  author    = {Baader, Fabian and Reiswich, M. and Bartsch, M. and Keller, D. and Tiede, E. and Keck, G. and Demircian, A. and Friedrich, M. and Dachwald, Bernd and Sch{\"u}ller, K. and Lehmann, R. and Chojetzki, R. and Durand, C. and Rapp, L. and Kowalski, Julia and F{\"o}rstner, R.},
  title     = {VIPER - Student research on extraterrestrical ice penetration technology},
  series = {Proceedings of the 2nd Symposium on Space Educational Activities},
  booktitle = {Proceedings of the 2nd Symposium on Space Educational Activities},
  pages     = {1 -- 6},
  year      = {2018},
  abstract  = {Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process.},
  language  = {en}
}
@inproceedings{BaaderKellerLehmannetal.2019,
  author    = {Baader, Fabian and Keller, Denis and Lehmann, Raphael and Gerber, Lukas and Reiswich, Martin and Dachwald, Bernd and F{\"o}rstner, Roger},
  title     = {Operating melting probes for ice penetration under sublimation conditions and in reduced gravity on a sounding rocket},
  series = {Proceedings of the 24th ESA Symposium on European Rocket and Balloon Programmes and related Research},
  booktitle = {Proceedings of the 24th ESA Symposium on European Rocket and Balloon Programmes and related Research},
  issn      = {0379-6566},
  pages     = {8 Seiten},
  year      = {2019},
  language  = {en}
}
@incollection{AzatKerimkulovaMansurovetal.2020,
  author    = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard},
  title     = {The Use of Fusicoccin as Anticancer Compound},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {New York},
  isbn      = {978-0-429-42864-7},
  doi       = {10.1201/9780429428647-8},
  pages     = {149 -- 172},
  year      = {2020},
  abstract  = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.},
  language  = {en}
}
@inproceedings{AzarDigel2019,
  author    = {Azar, Fouad and Digel, Ilya},
  title     = {Utilization of fluorescence spectroscopy and neural networks in clinical analysis},
  series = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen},
  booktitle = {3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen},
  editor    = {Staat, Manfred and Erni, Daniel},
  publisher = {Universit{\"a}t Duisburg-Essen},
  address   = {Duisburg},
  organization    = {MedTech Symposium},
  isbn      = {978-3-940402-22-6},
  doi       = {10.17185/duepublico/48750},
  pages     = {40 -- 41},
  year      = {2019},
  abstract  = {Fluorescence topography of human urine in combination with learning algorithms can provide a variant pattern recognition method in analytical clinical chemistry and, eventually, diagnosis.},
  language  = {en}
}
@article{AttarMerkKotliaretal.2019,
  author    = {Attar, Mandana Hossein Zadeh and Merk, Hans F. and Kotliar, Konstantin and Wurpts, Gerda and R{\"o}seler, Stefani and Moll-Slodowy, Silke and Plange, Johann and Baron, Jens Malte and Balakirski, Galina},
  title     = {The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria},
  series = {European Journal of Dermatology},
  volume    = {29},
  journal   = {European Journal of Dermatology},
  number    = {6},
  doi       = {10.1684/ejd.2019.3680},
  pages     = {614 -- 618},
  year      = {2019},
  language  = {en}
}
@article{ArtmannZhouStacheBuettneretal.2002,
  author    = {Artmann, Gerhard and Zhou-Stache, J. and Buettner, R. and Mittermayer, C. [u.a.]},
  title     = {Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K.},
  series = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  journal   = {Medical and Biological Engineering and Computing. 40 (2002), H. 6},
  isbn      = {0140-0118},
  pages     = {698 -- 703},
  year      = {2002},
  language  = {en}
}
@article{ArtmannZerlinDigeletal.2007,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya and Stadler, Andreas M.},
  title     = {Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA},
  series = {Tissue Engineering. 13 (2007), H. 7},
  journal   = {Tissue Engineering. 13 (2007), H. 7},
  isbn      = {1076-3279},
  pages     = {1778 -- 1778},
  year      = {2007},
  language  = {en}
}
@article{ArtmannZerlinDigel2008,
  author    = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya},
  title     = {Hemoglobin Senses Body Temperature},
  series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  journal   = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  pages     = {415 -- 447},
  year      = {2008},
  language  = {en}
}
@article{ArtmannTrzewikAtes2002,
  author    = {Artmann, Gerhard and Trzewik, J{\"u}rgen and Ates, M.},
  title     = {A novel method to quantify mechanical tension in cell monolayers. Trzewik, J{\"u}rgen; Ates, M., Artmann, Gerhard Michael},
  series = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1},
  journal   = {Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1},
  isbn      = {0013-5585},
  pages     = {379 -- 381},
  year      = {2002},
  language  = {en}
}
@book{ArtmannTemizArtmannZhubanovaetal.2018,
  author    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  title     = {Biological, physical and technical basics of cell engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7903-0},
  pages     = {xxiv, 481 Seiten ; Illustrationen, Diagramme},
  year      = {2018},
  language  = {en}
}
@inproceedings{ArtmannStadlerEmbsetal.2010,
  author    = {Artmann, Gerhard and Stadler, Andreas M. and Embs, Jan P. and Zaccai, Giuseppe and B{\"u}ldt, Georg and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l},
  title     = {The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]},
  year      = {2010},
  abstract  = {The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature},
  subject      = {H{\"a}moglobin},
  language  = {en}
}
@incollection{ArtmannMeruvuKizildagetal.2018,
  author    = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l},
  title     = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures},
  series = {Biological, Physical and Technical Basics of Cell Engineering},
  booktitle = {Biological, Physical and Technical Basics of Cell Engineering},
  editor    = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya},
  publisher = {Springer},
  address   = {Singapore},
  isbn      = {978-981-10-7904-7},
  doi       = {10.1007/978-981-10-7904-7_7},
  pages     = {157 -- 192},
  year      = {2018},
  abstract  = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.},
  language  = {en}
}
@misc{ArtmannLinderBayeretal.2017,
  author    = {Artmann, Gerhard and Linder, Peter and Bayer, Robin and Gossmann, Matthias},
  title     = {Celldrum electrode arrangement for measuring mechanical stress [Patent of invention]},
  publisher = {WIPO},
  address   = {Geneva},
  pages     = {18 Seiten},
  year      = {2017},
  abstract  = {The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance.},
  language  = {en}
}
@article{ArtmannHueckRossiteretal.2008,
  author    = {Artmann, Gerhard and Hueck, Isgard S. and Rossiter, Katharine and Schmid-Sch{\"o}nbein, Geert W.},
  title     = {Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Sch{\"o}nbein, Geert W.},
  series = {Microcirculation. 15 (2008), H. 6},
  journal   = {Microcirculation. 15 (2008), H. 6},
  isbn      = {1549-8719},
  pages     = {531 -- 542},
  year      = {2008},
  language  = {en}
}
@article{ArtmannDigelZerlinetal.2009,
  author    = {Artmann, Gerhard and Digel, Ilya and Zerlin, Kay and Maggakis-Kelemen, Christina and Linder, Peter and Porst, Dariusz and Kayser, Peter and Stadler, David and Dikta, Gerhard and Temiz Artmann, Ayseg{\"u}l},
  title     = {Hemoglobin senses body temperature},
  series = {European Biophysics Journal},
  volume    = {38},
  journal   = {European Biophysics Journal},
  number    = {5},
  isbn      = {0175-7571},
  pages     = {589 -- 600},
  year      = {2009},
  language  = {en}
}
@inproceedings{ArtmannDigelLinderetal.2011,
  author    = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Temiz Artmann, Ayseg{\"u}l},
  title     = {Biophysical and Engineering Contributions to Plant Research},
  year      = {2011},
  abstract  = {Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in-situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves.},
  subject      = {Pflanzenphysiologie},
  language  = {en}
}
@article{ArtmannDigelLinderetal.2008,
  author    = {Artmann, Gerhard and Digel, Ilya and Linder, Peter and Porst, Dariusz},
  title     = {Mechanism of haemoglobin sensing body temperature},
  series = {Tissue Engineering Part A. 14 (2008), H. 5},
  journal   = {Tissue Engineering Part A. 14 (2008), H. 5},
  isbn      = {1937-3341},
  pages     = {754 -- 754},
  year      = {2008},
  language  = {en}
}
@techreport{ArtmannBaeumler2002,
  author    = {Artmann, Gerhard and B{\"a}umler, H.},
  title     = {Pharmamikrocontainer mit designgesteuerter Permeabilit{\"a}t als Transporter f{\"u}r ausgew{\"a}hlte Pharmaka. Ein Gemeinschaftsprojekt im Forschungsschwerpunkt "Celluar Engineering" [Laufzeit: 01.09.2000 - 28.02.2002]},
  publisher = {FH Aachen},
  address   = {J{\"u}lich},
  year      = {2002},
  language  = {de}
}
@article{ArtmannBurnsCanavesetal.2004,
  author    = {Artmann, Gerhard and Burns, Laura and Canaves, Jaume M. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature},
  series = {European Biophysics Journal. 33 (2004), H. 6},
  journal   = {European Biophysics Journal. 33 (2004), H. 6},
  isbn      = {1432-1017},
  pages     = {490 -- 496},
  year      = {2004},
  language  = {en}
}
@book{Artmann2008,
  author    = {Artmann, Gerhard},
  title     = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-540-75408-4},
  year      = {2008},
  language  = {en}
}
@book{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds.},
  publisher = {Springer},
  address   = {Berlin [u.a.]},
  isbn      = {978-3-642-11864-7},
  pages     = {XLI, 541 S. : Ill., graph. Darst.},
  year      = {2011},
  language  = {en}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "F{\"o}rderung von innovativen Netzwerken" (InnoNet) des Bundesministerium f{\"u}r Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen [u.a.]},
  doi       = {10.2314/GBV:68757076X},
  year      = {2011},
  language  = {de}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:782964621},
  year      = {2011},
  language  = {de}
}
@techreport{Artmann2004,
  author    = {Artmann, Gerhard},
  title     = {Escherichia Coli Infektion und Zellsch{\"a}digung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {J{\"u}lich},
  doi       = {10.2314/GBV:482527137},
  year      = {2004},
  language  = {de}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten. Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:747569150},
  year      = {2011},
  language  = {de}
}
@article{ArinkinDigelPorstetal.2014,
  author    = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application},
  series = {BMC bioinformatics},
  volume    = {15},
  journal   = {BMC bioinformatics},
  number    = {55},
  issn      = {1471-2105},
  doi       = {10.1186/1471-2105-15-55},
  pages     = {1 -- 8},
  year      = {2014},
  abstract  = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.},
  language  = {en}
}
@inproceedings{ArinkinDigel2009,
  author    = {Arinkin, Vladimir and Digel, Ilya},
  title     = {Water bridge phenomenon : [abstract]},
  year      = {2009},
  abstract  = {One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge"},
  subject      = {Hydrodynamik},
  language  = {en}
}
@article{ArampatzisPeperBierbaumetal.2010,
  author    = {Arampatzis, Adamantios and Peper, Andreas and Bierbaum, Stefanie and Albracht, Kirsten},
  title     = {Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain},
  series = {Journal of Biomechanics},
  volume    = {43},
  journal   = {Journal of Biomechanics},
  number    = {16},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2010.08.014},
  pages     = {3073 -- 3079},
  year      = {2010},
  abstract  = {The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47\%), and the other leg at high tendon strain magnitude (4.72±1.08\%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon-aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon-aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.},
  language  = {en}
}
@article{ArampatzisKaramanidisMademlietal.2009,
  author    = {Arampatzis, Adamantios and Karamanidis, Kiros and Mademli, Lida and Albracht, Kirsten},
  title     = {Plasticity of the human tendon to short and long-term mechanical loading},
  series = {Exercise and Sport Sciences Reviews},
  volume    = {37},
  journal   = {Exercise and Sport Sciences Reviews},
  number    = {2},
  issn      = {1538-3008},
  doi       = {10.1097/JES.0b013e31819c2e1d},
  pages     = {66 -- 72},
  year      = {2009},
  language  = {en}
}
@article{ArampatzisKaramanidisAlbracht2007,
  author    = {Arampatzis, Adamantios and Karamanidis, Kiros and Albracht, Kirsten},
  title     = {Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude},
  series = {Journal of Experimental Biology},
  volume    = {210},
  journal   = {Journal of Experimental Biology},
  number    = {15},
  issn      = {0022-0949},
  doi       = {10.1242/jeb.003814},
  pages     = {2743 -- 2753},
  year      = {2007},
  language  = {en}
}
@article{AngermannGuenthnerHanssenetal.2022,
  author    = {Angermann, Susanne and G{\"u}nthner, Roman and Hanssen, Henner and Lorenz, Georg and Braunisch, Matthias C. and Steubl, Dominik and Matschkal, Julia and Kemmner, Stephan and Hausinger, Renate and Block, Zenonas and Haller, Bernhard and Heemann, Uwe and Kotliar, Konstantin and Grimmer, Timo and Schmaderer, Christoph},
  title     = {Cognitive impairment and microvascular function in end-stage renal disease},
  series = {International Journal of Methods in Psychiatric Research (MPR)},
  volume    = {31},
  journal   = {International Journal of Methods in Psychiatric Research (MPR)},
  number    = {2},
  publisher = {Wiley},
  issn      = {1049-8931 (Print)},
  doi       = {10.1002/mpr.1909},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.},
  language  = {en}
}
@article{AndingTabazaStaatetal.2013,
  author    = {Anding, Ralf and Tabaza, Ruth and Staat, Manfred and Trenz, Eva and Lohmann, Philipp and Klinge, Uwe and Kirschner-Hermanns, Ruth},
  title     = {Introducing a method of in vitro testing of different anchoring systems used for female incontinence and prolapse surgery},
  series = {BioMed research international},
  volume    = {Vol. 2013},
  journal   = {BioMed research international},
  issn      = {1110-7251 (E-Journal); 2314-6141 (E-Journal); 1110-7243 (Print); 2314-6133 (Print)},
  pages     = {Article ID 401417},
  year      = {2013},
  language  = {en}
}
@article{AminTemizArtmannArtmannetal.2009,
  author    = {Amin, Rashid and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Lazarovici, Philip and Lelkes, Peter I.},
  title     = {Permeability of an In Vitro Model of Blood Brain Barrier (BBB)},
  series = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]},
  journal   = {13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.]},
  isbn      = {978-3-540-92841-6},
  pages     = {81 -- 84},
  year      = {2009},
  language  = {en}
}
@article{AlnemerKotliarNeuhausetal.2023,
  author    = {Alnemer, Momin Sami Mohammad and Kotliar, Konstantin and Neuhaus, Valentin and Pape, Hans-Christoph and Ciritsis, Bernhard D.},
  title     = {Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model},
  series = {Cost Effectiveness and Resource Allocation},
  journal   = {Cost Effectiveness and Resource Allocation},
  number    = {21, Article number: 77},
  publisher = {Springer Nature},
  issn      = {1478-7547},
  doi       = {10.1186/s12962-023-00482-4},
  pages     = {12 Seiten},
  year      = {2023},
  abstract  = {Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare \& Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10\% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10\% fracture risk reduction, model A costs between \$8,850 and \$46,940 per quality-adjusted life-year (\$/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8\% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side's prophylaxis, the patient's age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between \$11,000/QALY and \$74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.},
  language  = {en}
}
@article{AlexyukBogoyavlenskiyAlexyuketal.2021,
  author    = {Alexyuk, Madina and Bogoyavlenskiy, Andrey and Alexyuk, Pavel and Moldakhanov, Yergali and Berezin, Vladimir and Digel, Ilya},
  title     = {Epipelagic microbiome of the Small Aral Sea: Metagenomic structure and ecological diversity},
  series = {MicrobiologyOpen},
  volume    = {10},
  journal   = {MicrobiologyOpen},
  number    = {1},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {2045-8827},
  doi       = {10.1002/mbo3.1142},
  pages     = {1 -- 10},
  year      = {2021},
  abstract  = {Microbial diversity studies regarding the aquatic communities that experienced or are experiencing environmental problems are essential for the comprehension of the remediation dynamics. In this pilot study, we present data on the phylogenetic and ecological structure of microorganisms from epipelagic water samples collected in the Small Aral Sea (SAS). The raw data were generated by massive parallel sequencing using the shotgun approach. As expected, most of the identified DNA sequences belonged to Terrabacteria and Actinobacteria (40\% and 37\% of the total reads, respectively). The occurrence of Deinococcus-Thermus, Armatimonadetes, Chloroflexi in the epipelagic SAS waters was less anticipated. Surprising was also the detection of sequences, which are characteristic for strict anaerobes—Ignavibacteria, hydrogen-oxidizing bacteria, and archaeal methanogenic species. We suppose that the observed very broad range of phylogenetic and ecological features displayed by the SAS reads demonstrates a more intensive mixing of water masses originating from diverse ecological niches of the Aral-Syr Darya River basin than presumed before.},
  language  = {en}
}
@article{AlbrachtArampatzis2013,
  author    = {Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans},
  series = {European Journal of Applied Physiology},
  volume    = {113},
  journal   = {European Journal of Applied Physiology},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1439-6327},
  doi       = {10.1007/s00421-012-2585-4},
  pages     = {1605 -- 1615},
  year      = {2013},
  language  = {en}
}
@article{AlbrachtArampatzis2006,
  author    = {Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy},
  series = {Biological Cybernetics},
  volume    = {95},
  journal   = {Biological Cybernetics},
  number    = {1},
  issn      = {1432-0770},
  doi       = {10.1007/s00422-006-0070-z},
  pages     = {87 -- 96},
  year      = {2006},
  language  = {en}
}
@article{AlbrachtArampatzisBaltzopoulos2008,
  author    = {Albracht, Kirsten and Arampatzis, A. and Baltzopoulos, V.},
  title     = {Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo},
  series = {Journal of Biomechanics},
  volume    = {41},
  journal   = {Journal of Biomechanics},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2008.04.020},
  pages     = {2211 -- 2218},
  year      = {2008},
  language  = {en}
}
@phdthesis{Albracht2010,
  author    = {Albracht, Kirsten},
  title     = {Influence of mechanical properties of the leg extensor muscletendon units on running economy},
  publisher = {Deutsche Sporthochschule K{\"o}ln},
  address   = {K{\"o}ln},
  pages     = {X, 1221 Bl. : graph. Darst.},
  year      = {2010},
  language  = {en}
}
@article{AlbannaLuekeSchubertetal.2019,
  author    = {Albanna, Walid and L{\"u}ke, Jan Niklas and Schubert, Gerrit Alexander and Dibu{\´e}-Adjei, Maxine and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Steiger, Hans-Jakob and H{\"a}nggi, Daniel and Kamp, Marcel A. and Schneider, Toni and Neumaier, Felix},
  title     = {Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity},
  series = {Molecular and Cellular Neuroscience},
  volume    = {96},
  journal   = {Molecular and Cellular Neuroscience},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1044-7431},
  doi       = {10.1016/j.mcn.2019.03.003},
  pages     = {35 -- 46},
  year      = {2019},
  language  = {en}
}
@article{AlbannaLuekeSjapicetal.2017,
  author    = {Albanna, Walid and Lueke, Jan Niklas and Sjapic, Volha and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Sjapic, Sergej and Alpdogan, Serdan and Schneider, Toni and Schubert, Gerrit Alexander and Neumaier, Felix},
  title     = {Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina},
  series = {Current Eye Research},
  journal   = {Current Eye Research},
  number    = {Article in press},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1460-2202},
  doi       = {10.1080/02713683.2017.1339807},
  pages     = {1 -- 9},
  year      = {2017},
  language  = {en}
}
@article{AlbannaKotliarLuekeetal.2018,
  author    = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander},
  title     = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis},
  series = {Plos one},
  volume    = {13},
  journal   = {Plos one},
  number    = {10},
  publisher = {PLOS},
  address   = {San Francisco},
  doi       = {10.1371/journal.pone.0204689},
  pages     = {e0204689},
  year      = {2018},
  abstract  = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.},
  language  = {en}
}
@article{AlbannaConzenWeissetal.2021,
  author    = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander},
  title     = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis},
  series = {Frontiers in Neurology},
  volume    = {12},
  journal   = {Frontiers in Neurology},
  number    = {12},
  issn      = {1664-2295},
  doi       = {10.3389/fneur.2021.690183},
  pages     = {1 -- 15},
  year      = {2021},
  abstract  = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.},
  language  = {en}
}
@article{AlbannaConzenWeissetal.2016,
  author    = {Albanna, W. and Conzen, C. and Weiss, M. and Clusmann, H. and Fuest, M. and Mueller, M. and Brockmann, M.A. and Vilser, W. and Schmidt-Trucks{\"a}ss, A. and Hoellig, A. and Seiz, M. and Thom{\´e}, C. and Kotliar, Konstantin and Schubert, G.A.},
  title     = {Retinal Vessel Analysis (RVA) in the context of subarachnoid hemorrhage: A proof of concept study},
  series = {PLoS ONE},
  volume    = {11},
  journal   = {PLoS ONE},
  number    = {7},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0158781},
  pages     = {13 Seiten},
  year      = {2016},
  abstract  = {Background Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2-14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results Image quality was satisfactory in the majority of cases (93.3\%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p<0.01), a difference that persisted to a lesser extent in the later stage of the disease (122.7±17.2MU, p<0.05). Testing for neurovascular coupling showed a trend towards impaired primary vasodilation and secondary vasoconstriction (p = 0.08, p = 0.09 resp.) initially and partial recovery at the time of follow-up, indicating a relative improvement in a time-dependent fashion. Conclusion RVA is technically feasible in patients with SAH and can detect fluctuations in vessel diameter and autoregulation even in less severely affected patients. Preliminary data suggests potential for RVA as a new and non-invasive tool for advanced SAH monitoring, but clinical relevance and prognostic value will have to be determined in a larger cohort.},
  language  = {en}
}
@incollection{AkimbekovZhanadilovnaUalievaetal.2020,
  author    = {Akimbekov, Nuraly and Zhanadilovna, Abdieva G. and Ualieva, Perizat S. and Abaihanovna, Zhusipova D. and Digel, Ilya and Savitskaya, Irina S. and Zhubanova, Azhar Achmet},
  title     = {Functionalization of Carbon Based Wound Dressings with Antimicrobial Phytoextracts for Bioactive Treatment of Septic Wounds},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {Singapore},
  isbn      = {978-981-4800-27-3},
  doi       = {10.1201/9780429428647-11},
  pages     = {211 -- 228},
  year      = {2020},
  abstract  = {The treatment of septic wounds with curative dressings based on biocomposites containing sage and marigold phytoextracts was effective in in vitro and in vivo experiments. These dressings caused the purification of the wound surface from purulent-necrotic masses three days earlier than in the other experimental groups. The consequence of an increase in incidents of severe course of the wound and the observed tendency to increase the number of adverse effects is the development of long-term recurrent wound processes. To treat purulent wounds, the following tactics were used: The purulent wounds of animals were covered with the examined wound dressing, and then the next day samples were taken, the procedure was performed once in 2 days. To obtain the active nanostructured sorbents such as carbonized rice husks, they are functionalized with biologically active components possessing antimicrobial, anti-inflammatory, antitoxic, immunomodulating, antiallergic and other types of properties.},
  language  = {en}
}
@article{AkimbekovMansurovJandosovetal.2013,
  author    = {Akimbekov, Nuraly Shardarbekovich and Mansurov, Zulkhair and Jandosov, J. and Digel, Ilya and Gossmann, Matthias and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A.},
  title     = {Wound healing activity of carbonized rice husk},
  publisher = {Trans Tech Publications, Switzerland},
  address   = {B{\"a}ch},
  year      = {2013},
  abstract  = {The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls.},
  subject      = {Wundheilung},
  language  = {en}
}
@article{AkimbekovDigelTastambeketal.2021,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Tastambek, Kuanysh T. and Sherelkhan, Dinara K. and Jussupova, Dariya B. and Altynbay, Nazym P.},
  title     = {Low-rank coal as a source of humic substances for soil amendment and fertility management},
  series = {Agriculture},
  volume    = {11},
  journal   = {Agriculture},
  number    = {12},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2077-0472},
  doi       = {10.3390/agriculture11121261},
  pages     = {25 Seiten},
  year      = {2021},
  abstract  = {Humic substances (HS), as important environmental components, are essential to soil health and agricultural sustainability. The usage of low-rank coal (LRC) for energy generation has declined considerably due to the growing popularity of renewable energy sources and gas. However, their potential as soil amendment aimed to maintain soil quality and productivity deserves more recognition. LRC, a highly heterogeneous material in nature, contains large quantities of HS and may effectively help to restore the physicochemical, biological, and ecological functionality of soil. Multiple emerging studies support the view that LRC and its derivatives can positively impact the soil microclimate, nutrient status, and organic matter turnover. Moreover, the phytotoxic effects of some pollutants can be reduced by subsequent LRC application. Broad geographical availability, relatively low cost, and good technical applicability of LRC offer the advantage of easy fulfilling soil amendment and conditioner requirements worldwide. This review analyzes and emphasizes the potential of LRC and its numerous forms/combinations for soil amelioration and crop production. A great benefit would be a systematic investment strategy implicating safe utilization and long-term application of LRC for sustainable agricultural production.},
  language  = {en}
}
@article{AkimbekovDigelTastambeketal.2022,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Tastambek, Kuanysh T. and Marat, Adel K. and Turaliyeva, Moldir A. and Kaiyrmanova, Gulzhan K.},
  title     = {Biotechnology of Microorganisms from Coal Environments: From Environmental Remediation to Energy Production},
  series = {Biology},
  volume    = {11},
  journal   = {Biology},
  number    = {9},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2079-7737},
  doi       = {10.3390/biology11091306},
  pages     = {47 Seiten},
  year      = {2022},
  abstract  = {It was generally believed that coal sources are not favorable as live-in habitats for microorganisms due to their recalcitrant chemical nature and negligible decomposition. However, accumulating evidence has revealed the presence of diverse microbial groups in coal environments and their significant metabolic role in coal biogeochemical dynamics and ecosystem functioning. The high oxygen content, organic fractions, and lignin-like structures of lower-rank coals may provide effective means for microbial attack, still representing a greatly unexplored frontier in microbiology. Coal degradation/conversion technology by native bacterial and fungal species has great potential in agricultural development, chemical industry production, and environmental rehabilitation. Furthermore, native microalgal species can offer a sustainable energy source and an excellent bioremediation strategy applicable to coal spill/seam waters. Additionally, the measures of the fate of the microbial community would serve as an indicator of restoration progress on post-coal-mining sites. This review puts forward a comprehensive vision of coal biodegradation and bioprocessing by microorganisms native to coal environments for determining their biotechnological potential and possible applications.},
  language  = {en}
}
@incollection{AkimbekovDigelSherelkhanetal.2022,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Sherelkhan, Dinara K. and Razzaque, Mohammed S.},
  title     = {Vitamin D and Phosphate Interactions in Health and Disease},
  series = {Phosphate Metabolism},
  booktitle = {Phosphate Metabolism},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-91621-3},
  doi       = {10.1007/978-3-030-91623-7_5},
  pages     = {37 -- 46},
  year      = {2022},
  abstract  = {Vitamin D plays an essential role in calcium and inorganic phosphate (Pi) homeostasis, maintaining their optimal levels to assure adequate bone mineralization. Vitamin D, as calcitriol (1,25(OH)2D), not only increases intestinal calcium and phosphate absorption but also facilitates their renal reabsorption, leading to elevated serum calcium and phosphate levels. The interaction of 1,25(OH)2D with its receptor (VDR) increases the efficiency of intestinal absorption of calcium to 30-40\% and phosphate to nearly 80\%. Serum phosphate levels can also influence 1,25 (OH)2D and fibroblast growth factor 23 (FGF23) levels, i.e., higher phosphate concentrations suppress vitamin D activation and stimulate parathyroid hormone (PTH) release, while a high FGF23 serum level leads to reduced vitamin D synthesis. In the vitamin D-deficient state, the intestinal calcium absorption decreases and the secretion of PTH increases, which in turn causes the stimulation of 1,25(OH)2D production, resulting in excessive urinary phosphate loss. Maintenance of phosphate homeostasis is essential as hyperphosphatemia is a risk factor of cardiovascular calcification, chronic kidney diseases (CKD), and premature aging, while hypophosphatemia is usually associated with rickets and osteomalacia. This chapter elaborates on the possible interactions between vitamin D and phosphate in health and disease.},
  language  = {en}
}
@article{AkimbekovDigelSherelkhanetal.2020,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and Sherelkhan, Dinara K. and Lutfor, Afzalunnessa B. and Razzaque, Mohammed S.},
  title     = {Vitamin D and the Host-Gut Microbiome: A Brief Overview},
  series = {Acta Histochemica et Cytochemica},
  volume    = {53},
  journal   = {Acta Histochemica et Cytochemica},
  number    = {3},
  publisher = {Japan Society of Histochemistry and Cytochemistry},
  address   = {Osaka},
  issn      = {1347-5800},
  doi       = {10.1267/ahc.20011},
  pages     = {33 -- 42},
  year      = {2020},
  abstract  = {There is a growing body of evidence for the effects of vitamin D on intestinal host-microbiome interactions related to gut dysbiosis and bowel inflammation. This brief review highlights the potential links between vitamin D and gut health, emphasizing the role of vitamin D in microbiological and immunological mechanisms of inflammatory bowel diseases. A comprehensive literature search was carried out in PubMed and Google Scholar using combinations of keywords "vitamin D," "intestines," "gut microflora," "bowel inflammation". Only articles published in English and related to the study topic are included in the review. We discuss how vitamin D (a) modulates intestinal microbiome function, (b) controls antimicrobial peptide expression, and (c) has a protective effect on epithelial barriers in the gut mucosa. Vitamin D and its nuclear receptor (VDR) regulate intestinal barrier integrity, and control innate and adaptive immunity in the gut. Metabolites from the gut microbiota may also regulate expression of VDR, while vitamin D may influence the gut microbiota and exert anti-inflammatory and immune-modulating effects. The underlying mechanism of vitamin D in the pathogenesis of bowel diseases is not fully understood, but maintaining an optimal vitamin D status appears to be beneficial for gut health. Future studies will shed light on the molecular mechanisms through which vitamin D and VDR interactions affect intestinal mucosal immunity, pathogen invasion, symbiont colonization, and antimicrobial peptide expression.},
  language  = {en}
}