@article{KirchnerLiSpelthahnetal.2011, author = {Kirchner, Patrick and Li, Bin and Spelthahn, Heiko and Henkel, Hartmut and Schneider, Andreas and Friedrich, Peter and Kolstad, Jens and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Thin-film calorimetric H2O2 gas sensor for the validation of germicidal effectivity in aseptic filling processes}, series = {Sensors and Actuators B: Chemical. 154 (2011), H. 2}, journal = {Sensors and Actuators B: Chemical. 154 (2011), H. 2}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1873-3077}, pages = {257 -- 263}, year = {2011}, language = {en} } @inproceedings{KloockSchubertErmelenkoetal.2006, author = {Kloock, Joachim P. and Schubert, J. and Ermelenko, Y. and Vlasov, Y. G. and Bratov, A. and Sch{\"o}ning, Michael Josef}, title = {Thin-film sensors with chalcogenide glass materials - a general survey}, series = {Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...}, booktitle = {Biochemical sensing utilisation of micro- and nanotechnologies : Warsaw, [23rd - 26th] November 2005 / ed. by M. Mascini ...}, address = {Warsaw}, pages = {92 -- 97}, year = {2006}, language = {en} } @inproceedings{KernImaniVashianiTimmermanns2021, author = {Kern, Alexander and Imani Vashiani, Anahita and Timmermanns, Tobias}, title = {Threat for human beings due to touch voltages and body currents caused by direct lightning strikes in case of non-isolated lightning protection systems using natural components}, series = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)}, booktitle = {35th International Conference on Lightning Protection (ICLP) and XVI International Symposium on Lightning Protection (SIPDA)}, publisher = {IEEE}, address = {New York, NY}, isbn = {978-1-6654-2346-5}, doi = {10.1109/ICLPandSIPDA54065.2021.9627465}, pages = {8 Seiten}, year = {2021}, abstract = {For typical cases of non-isolated lightning protection systems (LPS) the impulse currents are investigated which may flow through a human body directly touching a structural part of the LPS. Based on a basic LPS model with conventional down-conductors especially the cases of external and internal steel columns and metal fa{\c{c}}ades are considered and compared. Numerical simulations of the line quantities voltages and currents in the time domain are performed with an equivalent circuit of the entire LPS. As a result it can be stated that by increasing the number of conventional down-conductors and external steel columns the threat for a human being can indeed be reduced, but not down to an acceptable limit. In case of internal steel columns used as natural down-conductors the threat can be reduced sufficiently, depending on the low-resistive connection of the steel columns to the lightning equipotential bonding or the earth termination system, resp. If a metal fa{\c{c}}ade is used the threat for human beings touching is usually very low, if the fa{\c{c}}ade is sufficiently interconnected and multiply connected to the lightning equipotential bonding or the earth termination system, resp.}, language = {en} } @article{MuellerVeggianLiederGono1977, author = {M{\"u}ller-Veggian, Mattea and Lieder, R. M. and Gono, Y.}, title = {Three particle-bands in ¹⁹⁵,¹⁹⁷ Tl}, series = {Annual report 1976 / Institut f{\"u}r Kernphysik Kernforschungsanlage J{\"u}lich / Ed. board: A. F{\"a}ßler ...}, journal = {Annual report 1976 / Institut f{\"u}r Kernphysik Kernforschungsanlage J{\"u}lich / Ed. board: A. F{\"a}ßler ...}, publisher = {Kernforschungsanlage}, address = {J{\"u}lich}, pages = {35}, year = {1977}, language = {en} } @inproceedings{HerrmannWorringerGraeteretal.2006, author = {Herrmann, Ulf and Worringer, S. and Graeter, F. and Nava, P.}, title = {Three Years of Operation Experience of the SKAL-ET Collector Loop at SEGS V}, series = {13th International Symposium Concentrated Solar Power and Chemical Energy Technologies, June 20 - 23, 2006, Seville, Spain}, booktitle = {13th International Symposium Concentrated Solar Power and Chemical Energy Technologies, June 20 - 23, 2006, Seville, Spain}, editor = {Romero, Manuel}, publisher = {SolarPACES [u.a.]}, address = {[s.l.]}, isbn = {84-7834-519-1}, pages = {1 CD-ROM}, year = {2006}, language = {en} } @article{Reissel1997, author = {Reißel, Martin}, title = {Three-dimensional eddy-current computation using Krylov subspace methods / Reissel, Martin}, series = {IMA Journal of Mathematics Applied in Business and Industry. 8 (1997), H. 2}, journal = {IMA Journal of Mathematics Applied in Business and Industry. 8 (1997), H. 2}, isbn = {1471-678X}, pages = {99 -- 121}, year = {1997}, language = {en} } @inproceedings{ValeroVogelSchmidtetal.2018, author = {Valero, Daniel and Vogel, Jochen and Schmidt, Daniel and Bung, Daniel Bernhard}, title = {Three-dimensional flow structure inside the cavity of a non-aerated stepped chute}, series = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May}, booktitle = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May}, isbn = {978-0-692-13277-7}, doi = {10.15142/T3GH17}, pages = {12 Seiten}, year = {2018}, language = {en} } @inproceedings{HessLuanSchwarteetal.2001, author = {Hess, Holger and Luan, Xuming and Schwarte, Rudolf and Zhang, Zhigang and Xu, Zhanping and Heinol, Horst-Guenther and Buxbaum, Bernd and Ringbeck, Thorsten}, title = {Three-dimensional intelligent sensing based on the PMD technology}, series = {Sensors, Systems, and Next-Generation Satellites V : 17 - 20 September 2001, Toulouse, France. - (SPIE proceedings series ; 4540)}, booktitle = {Sensors, Systems, and Next-Generation Satellites V : 17 - 20 September 2001, Toulouse, France. - (SPIE proceedings series ; 4540)}, editor = {Fujisada, Hiroyuki}, publisher = {SPIE}, address = {Bellingham, Wash.}, isbn = {0-8194-4265-8}, issn = {0038-7355}, pages = {482 -- 488}, year = {2001}, language = {en} } @article{TersteggeFlachskampfFrankeetal.1995, author = {Terstegge, Andreas and Flachskampf, F. A. and Franke, A. and Job, F. P. [u.a.]}, title = {Three-dimensional reconstruction of cardiac structures from transesophageal echocardiography}, series = {American journal of cardiac imaging. 9 (1995), H. 2}, journal = {American journal of cardiac imaging. 9 (1995), H. 2}, isbn = {0887-7971}, pages = {141 -- 147}, year = {1995}, language = {en} } @article{BalewskiBrauksiepeHardt1997, author = {Balewski, J. and Brauksiepe, S. and Hardt, Arno}, title = {Threshold measurements at the internal experimental facility COSY-11 / J. Balewski [u.a.]}, series = {Nuclear physics A. Vol. 626, iss. 1-2}, journal = {Nuclear physics A. Vol. 626, iss. 1-2}, issn = {1873-1554 (E-Journal) ; 0375-9474 (Print)}, pages = {85 -- 92}, year = {1997}, language = {en} } @article{KoehlerRoepkeWolf2021, author = {K{\"o}hler, Klemens and R{\"o}pke, Ren{\´e} and Wolf, Martin}, title = {Through a mirror darkly - On the obscurity of teaching goals in game-based learning in IT security}, series = {ISAGA 2019: Simulation Gaming Through Times and Disciplines}, journal = {ISAGA 2019: Simulation Gaming Through Times and Disciplines}, publisher = {Springer}, address = {Cham}, doi = {10.1007/978-3-030-72132-9_6}, pages = {61 -- 73}, year = {2021}, abstract = {Teachers and instructors use very specific language communicating teaching goals. The most widely used frameworks of common reference are the Bloom's Taxonomy and the Revised Bloom's Taxonomy. The latter provides distinction of 209 different teaching goals which are connected to methods. In Competence Developing Games (CDGs - serious games to convey knowledge) and in IT security education, a two- or three level typology exists, reducing possible learning outcomes to awareness, training, and education. This study explores whether this much simpler framework succeeds in achieving the same range of learning outcomes. Method wise a keyword analysis was conducted. The results were threefold: 1. The words used to describe teaching goals in CDGs on IT security education do not reflect the whole range of learning outcomes. 2. The word choice is nevertheless different from common language, indicating an intentional use of language. 3. IT security CDGs use different sets of terms to describe learning outcomes, depending on whether they are awareness, training, or education games. The interpretation of the findings is that the reduction to just three types of CDGs reduces the capacity to communicate and think about learning outcomes and consequently reduces the outcomes that are intentionally achieved.}, language = {en} } @incollection{ErnhardtDrummvanGogetal.2019, author = {Ernhardt, Selina and Drumm, Christian and van Gog, Tamara and Brand-Gruwel, Saskia and Jarodzka, Halszka}, title = {Through the eyes of a programmer : a research project on how to foster programming education with eye-tracking technology}, series = {Tagungsband zur 32. AKWI-Jahrestagung vom 15.09.2019 bis 18.09.2019 an der Fachhochschule f{\"u}r Angewandte Wissenschaften Aachen}, booktitle = {Tagungsband zur 32. AKWI-Jahrestagung vom 15.09.2019 bis 18.09.2019 an der Fachhochschule f{\"u}r Angewandte Wissenschaften Aachen}, publisher = {Mana-Buch}, address = {Heide}, isbn = {978-3-944330-62-4}, pages = {42 -- 47}, year = {2019}, language = {en} } @inproceedings{GregorioFatigatiKallweit2015, author = {Gregorio, Fabrizio de and Fatigati, Giovanni and Kallweit, Stephan}, title = {Tiltrotor airframe flow field characterization by SPIV}, series = {11th International Symposium on Partivle Image Velocimetry - PIV15 , Santa Barbara, California, Sept 14-16, 2015}, booktitle = {11th International Symposium on Partivle Image Velocimetry - PIV15 , Santa Barbara, California, Sept 14-16, 2015}, pages = {15 S.}, year = {2015}, language = {en} } @article{Kern1989, author = {Kern, Alexander}, title = {Time dependent temperature distribution in metal sheets caused by direct lightning strikes}, series = {Proceedings / Sixth International Symposium on High Voltage Engineering : 28. August - 1. September, 1989, Westin Canal Place Hotel, New Orleans, Louisiana, USA}, journal = {Proceedings / Sixth International Symposium on High Voltage Engineering : 28. August - 1. September, 1989, Westin Canal Place Hotel, New Orleans, Louisiana, USA}, publisher = {Mississippi State University}, address = {Mississippi State, Miss.}, year = {1989}, language = {en} } @inproceedings{FredebeulKrein2008, author = {Fredebeul-Krein, Markus}, title = {Time for revision: The regulation of Germany's next generation networks in the light of new economic and technological challenges on telecom markets : Presentation for the 18th Biennial conference of the International Telecommunications Society, June 24-27, 2008 Montreal, Canada}, year = {2008}, abstract = {On 1st January 1998, the German telecom market was fully liberalised. Since then genuine competition between market participants has developed, based on a comprehensive legal and regulatory framework that provides for safeguards against unfair competition and market power by Deutsche Telekom. Today, about 10 years after the liberalisation of the telecommunications sector a revision of this regulatory approach has become necessary because at least on three dimensions the situation is quite different from the one 10 years ago: First, with numerous established alternative operators in the market monopolies have been successfully challenged and competition introduced. Second, not only is Cable TV becoming in large parts of Germany a viable alternative for the provision of broadband services but also mobile services are becoming increasingly a substitute for fixed services. Last but not least there are important technological changes under way, requiring huge investments in infrastructure upgrades for next generation networks. In the light of these new developments the question is to which extent the current regulatory approach of severe ex-ante regulatory intervention is still appropriate. Is any part of the network of the former incumbent still a bottleneck? A more light handed regulatory approach might be the right response to this new situation. The paper is organised as follows: The first section will briefly examine the economic rationale for regulating network access. Based on the assumption that regulation is always necessary when bottlenecks exist regulatory principles for an efficient network access regime will be derived. The second section compares the situation of the German market in early 1998 with the one of today. Thereby three dimensions will be considered: the degree of competition, the potential for substitution and technological developments. The third section will define some requirements for the future regulation of telecom markets. Proposals will be elaborated how to ensure competitive telecom markets in the light of new economic and technological challenges.}, subject = {Telekommunikationsmarkt}, language = {en} } @article{KallweitVanlanduitVanherzeeleetal.2007, author = {Kallweit, Stephan and Vanlanduit, S. and Vanherzeele, J. and Brouns, M.}, title = {Time resolved PIV reconstruction of periodic flows / Vanlanduit, S. ; Vanherzeele, J. ; Kallweit, S. ; Brouns, M. ; Guillaume, P.}, series = {PIV'07, 7th International Symposium on Particle Image Velocimetry, Roma, IT, Sep 11-14, 2007}, journal = {PIV'07, 7th International Symposium on Particle Image Velocimetry, Roma, IT, Sep 11-14, 2007}, pages = {1 -- 14}, year = {2007}, language = {en} } @article{KallweitKaminskyRossietal.2005, author = {Kallweit, Stephan and Kaminsky, R. and Rossi, M. and Morbiducci, U.}, title = {Time resolved PIV technique for high temporal resolution measurements of prosthetic heart valves fluid dynamics / Kaminsky, R. ; Rossi, M. ; Morbiducci, U. ; Scalise, L. ; Catellini, P. ; Kallweit, S. ; Verdonck, P. ; Grigioni, M.}, series = {The International Journal of Artificial Organs. 28 (2005), H. 9}, journal = {The International Journal of Artificial Organs. 28 (2005), H. 9}, isbn = {1724-6040}, pages = {946}, year = {2005}, language = {en} } @inproceedings{BlankeSchmidtGoettscheetal.2022, author = {Blanke, Tobias and Schmidt, Katharina S. and G{\"o}ttsche, Joachim and D{\"o}ring, Bernd and Frisch, J{\´e}r{\^o}me and van Treeck, Christoph}, title = {Time series aggregation for energy system design: review and extension of modelling seasonal storages}, series = {Energy Informatics}, volume = {5}, booktitle = {Energy Informatics}, number = {1, Article number: 17}, editor = {Weidlich, Anke and Neumann, Dirk and Gust, Gunther and Staudt, Philipp and Sch{\"a}fer, Mirko}, publisher = {Springer Nature}, issn = {2520-8942}, doi = {10.1186/s42162-022-00208-5}, pages = {14 Seiten}, year = {2022}, abstract = {Using optimization to design a renewable energy system has become a computationally demanding task as the high temporal fluctuations of demand and supply arise within the considered time series. The aggregation of typical operation periods has become a popular method to reduce effort. These operation periods are modelled independently and cannot interact in most cases. Consequently, seasonal storage is not reproducible. This inability can lead to a significant error, especially for energy systems with a high share of fluctuating renewable energy. The previous paper, "Time series aggregation for energy system design: Modeling seasonal storage", has developed a seasonal storage model to address this issue. Simultaneously, the paper "Optimal design of multi-energy systems with seasonal storage" has developed a different approach. This paper aims to review these models and extend the first model. The extension is a mathematical reformulation to decrease the number of variables and constraints. Furthermore, it aims to reduce the calculation time while achieving the same results.}, language = {en} } @inproceedings{KromeSander2018, author = {Krome, Cornelia and Sander, Volker}, title = {Time series analysis with apache spark and its applications to energy informatics}, series = {Proceedings of the 7th DACH+ Conference on Energy Informatics}, booktitle = {Proceedings of the 7th DACH+ Conference on Energy Informatics}, doi = {10.1186/s42162-018-0043-1}, year = {2018}, abstract = {In energy economy forecasts of different time series are rudimentary. In this study, a prediction for the German day-ahead spot market is created with Apache Spark and R. It is just an example for many different applications in virtual power plant environments. Other examples of use as intraday price processes, load processes of machines or electric vehicles, real time energy loads of photovoltaic systems and many more time series need to be analysed and predicted. This work gives a short introduction into the project where this study is settled. It describes the time series methods that are used in energy industry for forecasts shortly. As programming technique Apache Spark, which is a strong cluster computing technology, is utilised. Today, single time series can be predicted. The focus of this work is on developing a method to parallel forecasting, to process multiple time series simultaneously with R and Apache Spark.}, language = {en} } @article{Dikta2006, author = {Dikta, Gerhard}, title = {Time series methods to forecast patent filings}, series = {Forecasting innovations : methods for predicting numbers of patent filings ; with 71 tables / Peter Hingley ; Marc Nicolas (ed.),}, journal = {Forecasting innovations : methods for predicting numbers of patent filings ; with 71 tables / Peter Hingley ; Marc Nicolas (ed.),}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-540-35991-3}, doi = {10.1007/3-540-35992-3_6}, pages = {95 -- 124}, year = {2006}, language = {en} } @article{GeierLehnertzBialonski2015, author = {Geier, Christian and Lehnertz, Klaus and Bialonski, Stephan}, title = {Time-dependent degree-degree correlations in epileptic brain networks: from assortative to dissortative mixing}, series = {Frontiers in Human Neuroscience}, journal = {Frontiers in Human Neuroscience}, publisher = {Frontiers Research Foundation}, address = {Lausanne}, issn = {1662-5161}, doi = {10.3389/fnhum.2015.00462}, year = {2015}, language = {en} } @article{OrzadaMaderwaldPoseretal.2012, author = {Orzada, S. and Maderwald, S. and Poser, B. A. and Johst, S. and Kannengiesser, S. and Ladd, M. E. and Bitz, Andreas}, title = {Time-interleaved acquisition of modes: an analysis of SAR and image contrast implications}, series = {Magnetic Resonance in Medicine}, volume = {67}, journal = {Magnetic Resonance in Medicine}, number = {4}, publisher = {Wiley-Liss}, address = {New York}, issn = {1522-2594}, doi = {10.1002/mrm.23081}, pages = {1033 -- 1041}, year = {2012}, abstract = {s the magnetic field strength and therefore the operational frequency in MRI are increased, the radiofrequency wavelength approaches the size of the human head/body, resulting in wave effects which cause signal decreases and dropouts. Especially, whole-body imaging at 7 T and higher is therefore challenging. Recently, an acquisition scheme called time-interleaved acquisition of modes has been proposed to tackle the inhomogeneity problems in high-field MRI. The basic premise is to excite two (or more) different Burn:x-wiley:07403194:media:MRM23081:tex2gif-stack-1 modes using static radiofrequency shimming in an interleaved acquisition, where the complementary radiofrequency patterns of the two modes can be exploited to improve overall signal homogeneity. In this work, the impact of time-interleaved acquisition of mode on image contrast as well as on time-averaged specific absorption rate is addressed in detail. Time-interleaved acquisition of mode is superior in Burn:x-wiley:07403194:media:MRM23081:tex2gif-stack-2 homogeneity compared with conventional radiofrequency shimming while being highly specific absorption rate efficient. Time-interleaved acquisition of modes can enable almost homogeneous high-field imaging throughout the entire field of view in PD, T2, and T2*-weighted imaging and, if a specified homogeneity criterion is met, in T1-weighted imaging as well.}, language = {en} } @inproceedings{RingbeckAlbrechtFreyetal.2003, author = {Ringbeck, Thorsten and Albrecht, M. and Frey, J. and [u.a.],}, title = {Time-of-Flight 3D-camera for autonomous navigation and industrial automation}, series = {Proceedings : 11th international conference, 13 - 15 May 2003, Exhibition Centre Nuremberg, Germany ; an event of the Association for Sensor Technology, AMA}, booktitle = {Proceedings : 11th international conference, 13 - 15 May 2003, Exhibition Centre Nuremberg, Germany ; an event of the Association for Sensor Technology, AMA}, editor = {Lerch, Reinhard}, edition = {CD-ROM-Ausg.}, publisher = {AMA Service}, address = {Wunstorf/Germany}, year = {2003}, language = {en} } @article{StreunBrandenburgKhodaverdietal.2006, author = {Streun, M. and Brandenburg, G. and Khodaverdi, M. and Larue, H. and Parl, C. and Ziemons, Karl}, title = {Timemark correction for the ClearPET™ scanners}, series = {2005 IEEE Nuclear Science Symposium Conference Record, Vol. 4}, journal = {2005 IEEE Nuclear Science Symposium Conference Record, Vol. 4}, isbn = {1082-3654}, pages = {2057 -- 2060}, year = {2006}, abstract = {The small animal PET scanners developed by the Crystal Clear Collaboration (ClearPETtrade) detect coincidences by analyzing timemarks which are attached to each event. The scanners are able to save complete single list mode data which allows analysis and modification of the timemarks after data acquisition. The timemarks are obtained from the digitally sampled detector pulses by calculating the baseline crossing of the rising edge of the pulse which is approximated as a straight line. But the limited sampling frequency causes a systematic error in the determination of the timemark. This error depends on the phase of the sampling clock at the time of the event. A statistical method that corrects these errors will be presented}, language = {en} } @article{HugenrothNeidlinEngelmannetal.2021, author = {Hugenroth, Kristin and Neidlin, Michael and Engelmann, Ulrich M. and Kaufmann, Tim A. S. and Steinseifer, Ulrich and Heilmann, Torsten}, title = {Tipless Transseptal Cannula Concept Combines Improved Hemodynamic Properties and Risk-Reduced Placement: an In Silico Proof-of-Concept}, series = {Artificial Organs}, journal = {Artificial Organs}, number = {Accepted Article}, publisher = {Wiley}, address = {Weinheim}, issn = {1525-1594}, doi = {10.1111/aor.13964}, year = {2021}, language = {en} } @article{ImmelGrothHuhnetal.2011, author = {Immel, Timo A. and Groth, Ulrich and Huhn, Thomas and {\"O}hlschl{\"a}ger, Peter}, title = {Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice}, series = {PLoS ONE}, volume = {6}, journal = {PLoS ONE}, number = {3}, publisher = {Plos}, address = {San Francisco, California, US}, doi = {10.1371/journal.pone.0017869}, pages = {e17869}, year = {2011}, abstract = {The anticancer activity of titanium complexes has been known since the groundbreaking studies of K{\"o}pf and K{\"o}pf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.}, language = {en} } @incollection{KochPoghossianWegeetal.2018, author = {Koch, Claudia and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {TMV-Based Adapter Templates for Enhanced Enzyme Loading in Biosensor Applications}, series = {Virus-Derived Nanoparticles for Advanced Technologies}, booktitle = {Virus-Derived Nanoparticles for Advanced Technologies}, editor = {Wege, Christina}, publisher = {Humana Press}, address = {New York, NY}, isbn = {978-1-4939-7808-3}, doi = {10.1007/978-1-4939-7808-3}, pages = {553 -- 568}, year = {2018}, abstract = {Nanotubular tobacco mosaic virus (TMV) particles and RNA-free lower-order coat protein (CP) aggregates have been employed as enzyme carriers in different diagnostic layouts and compared for their influence on biosensor performance. In the following, we describe a label-free electrochemical biosensor for improved glucose detection by use of TMV adapters and the enzyme glucose oxidase (GOD). A specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CP aggregates was achieved via bioaffinity binding. Glucose sensors with adsorptively immobilized [SA]-GOD, and with [SA]-GOD cross-linked with glutardialdehyde, respectively, were tested in parallel on the same sensor chip. Comparison of these sensors revealed that TMV adapters enhanced the amperometric glucose detection remarkably, conveying highest sensitivity, an extended linear detection range and fastest response times. These results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for applications in biosensorics and biochips. Here, we describe the fabrication and use of amperometric sensor chips combining an array of circular Pt electrodes, their loading with GOD-modified TMV nanotubes (and other GOD immobilization methods), and the subsequent investigations of the sensor performance.}, language = {en} } @book{Laack2007, author = {Laack, Walter van}, title = {To perceive the world with logic}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-936624-08-3}, pages = {340 S. : Ill., graph. Darst}, year = {2007}, language = {en} } @article{BaeckerKochEibenetal.2017, author = {B{\"a}cker, Matthias and Koch, Claudia and Eiben, Sabine and Geiger, Fania and Eber, Fabian and Gliemann, Hartmut and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors}, series = {Sensors and Actuators B: Chemical}, volume = {238}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.07.096}, pages = {716 -- 722}, year = {2017}, abstract = {The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.}, language = {en} } @article{HirschfeldLustfeldReisseletal.2010, author = {Hirschfeld, J. A. and Lustfeld, H. and Reißel, Martin and Steffen, B.}, title = {Tomographic diagnostics of current distributions in a fuel cell stack}, series = {International Journal of Energy Research}, volume = {34}, journal = {International Journal of Energy Research}, number = {3}, isbn = {0363-907X}, pages = {284 -- 292}, year = {2010}, language = {en} } @inproceedings{EllerwegRitz2008, author = {Ellerweg, Roland and Ritz, Thomas}, title = {Tool supported requirements analysis for the user centered development of mobile enterprise software}, series = {Proceeding of Wireless Applications and Computing 2008 and Telecommunications, Networks and Systems 2008 : MCCSIS '08 ; IADIS Multi Conference on Computer Science and Information Systems ; 22 - 24 July 2008, Amsterdam, The Netherlands}, booktitle = {Proceeding of Wireless Applications and Computing 2008 and Telecommunications, Networks and Systems 2008 : MCCSIS '08 ; IADIS Multi Conference on Computer Science and Information Systems ; 22 - 24 July 2008, Amsterdam, The Netherlands}, editor = {Roth, J{\"o}rg}, publisher = {IADIS Press}, address = {[Lisboa]}, isbn = {978-972-8924-62-1}, pages = {160 -- 162}, year = {2008}, abstract = {A user centered development method has proved satisfactory for the development of mobile enterprise software. To make use of this method, detailed information about the user and the place where the user interacts with his mobile device is required. This article describes how both can be modeled by a stereotypical and conceptual extended UML extension. Finally, a software tool is presented that supports the developed UML extension.}, language = {en} } @article{FischerKowalskiPudasaini2012, author = {Fischer, Jan-Thomas and Kowalski, Julia and Pudasaini, Shiva P.}, title = {Topographic curvature effects in applied avalanche modelling}, series = {Cold Regions Science and Technology}, volume = {74-75}, journal = {Cold Regions Science and Technology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-7441}, doi = {10.1016/j.coldregions.2012.01.005}, pages = {21 -- 30}, year = {2012}, abstract = {This paper describes the implementation of topographic curvature effects within the RApid Mass MovementS (RAMMS) snow avalanche simulation toolbox. RAMMS is based on a model similar to shallow water equations with a Coulomb friction relation and the velocity dependent Voellmy drag. It is used for snow avalanche risk assessment in Switzerland. The snow avalanche simulation relies on back calculation of observed avalanches. The calibration of the friction parameters depends on characteristics of the avalanche track. The topographic curvature terms are not yet included in the above mentioned classical model. Here, we fundamentally improve this model by mathematically and physically including the topographic curvature effects. By decomposing the velocity dependent friction into a topography dependent term that accounts for a curvature enhancement in the Coulomb friction, and a topography independent contribution similar to the classical Voellmy drag, we construct a general curvature dependent frictional resistance, and thus propose new extended model equations. With three site-specific examples, we compare the apparent frictional resistance of the new approach, which includes topographic curvature effects, to the classical one. Our simulation results demonstrate substantial effects of the curvature on the flow dynamics e.g., the dynamic pressure distribution along the slope. The comparison of resistance coefficients between the two models demonstrates that the physically based extension presents an improvement to the classical approach. Furthermore a practical example highlights its influence on the pressure outline in the run out zone of the avalanche. Snow avalanche dynamics modeling natural terrain curvature centrifugal force friction coefficients.}, language = {en} } @inproceedings{SchaenzleAltherrEdereretal.2015, author = {Sch{\"a}nzle, Christian and Altherr, Lena and Ederer, Thorsten and Pelz, Peter}, title = {TOR - Towards the energetically optimal ventilation system}, pages = {1 Seite}, year = {2015}, language = {en} } @inproceedings{PenneProfittlichRingbecketal.2010, author = {Penne, Jochen and Profittlich, Martin and Ringbeck, Thorsten and Buxbaum, Bernd}, title = {Touchless detailed 3D scan of human hand anatomy using time-of-flight cameras}, series = {Proceedings of the International Conference on 3D Body Scanning Technologies : Lugano, Switzerland, 19-20 October 2010}, booktitle = {Proceedings of the International Conference on 3D Body Scanning Technologies : Lugano, Switzerland, 19-20 October 2010}, editor = {D, Nicola D'Apuzzo}, publisher = {Hometrica Consulting}, address = {Z{\"u}rich}, isbn = {978-3-033-02714-5}, pages = {361 -- 369}, year = {2010}, language = {en} } @article{RoehlenPilasDahmenetal.2018, author = {R{\"o}hlen, Desiree and Pilas, Johanna and Dahmen, Markus and Keusgen, Michael and Selmer, Thorsten and Sch{\"o}ning, Michael Josef}, title = {Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes}, series = {Frontiers in Chemistry}, journal = {Frontiers in Chemistry}, number = {6}, publisher = {Frontiers}, address = {Lausanne}, doi = {10.3389/fchem.2018.00284}, pages = {Artikel 284}, year = {2018}, abstract = {Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.}, language = {en} } @article{ArreolaKeusgenSchoening2019, author = {Arreola, Julio and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Toward an immobilization method for spore-based biosensors in oxidative environment}, series = {Electrochimica Acta}, volume = {302}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.electacta.2019.01.148}, pages = {394 -- 401}, year = {2019}, language = {en} } @article{TakenagaBiselliSchnitzleretal.2014, author = {Takenaga, Shoko and Biselli, Manfred and Schnitzler, Thomas and {\"O}hlschl{\"a}ger, Peter and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis-Menten-like kinetics for cell culturing}, series = {Physica status solidi A : Applications and materials science}, volume = {211}, journal = {Physica status solidi A : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330464}, pages = {1410 -- 1415}, year = {2014}, abstract = {The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17-200 mM) follows a Michaelis-Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.}, language = {en} } @article{OberlaenderBrommWendeleretal.2015, author = {Oberl{\"a}nder, Jan and Bromm, Alexander and Wendeler, Luisa and Iken, Heiko and Palomar Duran, Marlena and Greeff, Anton and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a biosensor to monitor the sterilisation efficiency of aseptic filling machines}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431900}, pages = {1299 -- 1305}, year = {2015}, abstract = {Sterilisation processes are compulsory in medicine, pharmacy, and food industries to prevent infections of consumers and microbiological contaminations of products. Monitoring the sterilisation by conventional microbiological methods is time- and lab-consuming. To overcome this problem, in this work a novel biosensor has been proposed. The sensor enables a fast method to evaluate sterilisation processes. By means of thin-film technology the sensor's transducer structures in form of IDEs (interdigitated electrodes) have been fabricated on a silicon substrate. Physical characterisation of the developed sensor was done by AFM, SEM, and profilometry. Impedance analyses were conducted for the electrical characterisation. As microbiological layer spores of B. atrophaeus have been immobilised on the sensing structure; spores of this type are a well-known sterilisation test organism. Impedance measurements at a fixed frequency over time were performed to monitor the immobilisation process. A sterilisation process according to aseptic filling machines was applied to demonstrate the sensor functionality. After both, immobilisation and sterilisation, a change in impedance could successfully be detected.}, language = {en} } @article{SchoeningArzdorfMulchandanietal.2003, author = {Sch{\"o}ning, Michael Josef and Arzdorf, M. and Mulchandani, P. and Chen, W. and Mulchandani, A.}, title = {Towards a capacitive enzyme sensor for direct determination of organophosphorus pesticides: Fundamentals studies and aspects of development}, series = {Sensors. 3 (2003), H. 6}, journal = {Sensors. 3 (2003), H. 6}, isbn = {1424-8220}, pages = {119 -- 127}, year = {2003}, language = {en} } @inproceedings{GoemmelButenwegKob2005, author = {G{\"o}mmel, Andreas and Butenweg, Christoph and Kob, Malte}, title = {Towards a complete finite-element model of human phonation: modeling phonatory maneuvers}, series = {12th Workshop on the Finite Element Method in Biomedical Engineering, Biomechanics and Related Fields : Ulm, Germany, 20 - 21 July 2005 / University of Ulm, Department of Orthodontics ...}, booktitle = {12th Workshop on the Finite Element Method in Biomedical Engineering, Biomechanics and Related Fields : Ulm, Germany, 20 - 21 July 2005 / University of Ulm, Department of Orthodontics ...}, publisher = {Univ., Dep. of Orthodontics}, address = {Ulm}, organization = {Workshop on the Finite Element Method in Biomedical Engineering, Biomechanics and Related Fields <12, 2005, Ulm>}, isbn = {978-3-9806183-8-0}, pages = {1 CD-ROM}, year = {2005}, language = {en} } @inproceedings{BeckerEggertWinkelmannetal.2011, author = {Becker, J{\"o}rg and Eggert, Mathias and Winkelmann, Axel and Knackstedt, Ralf}, title = {Towards a Contingency Theory based Model of the Influence of Regulation on MIS}, series = {Proceedings of the Seventeenth Americas Conference on Information Systems, Detroit, Michigan August 4th -7 th 2011}, booktitle = {Proceedings of the Seventeenth Americas Conference on Information Systems, Detroit, Michigan August 4th -7 th 2011}, year = {2011}, language = {en} } @inproceedings{ChircuCzarneckiFriedmannetal.2023, author = {Chircu, Alina and Czarnecki, Christian and Friedmann, Daniel and Pomaskow, Johanna and Sultanow, Eldar}, title = {Towards a Digital Twin of Society}, series = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023}, booktitle = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023}, publisher = {University of Hawai'i}, address = {Honolulu}, isbn = {978-0-9981331-6-4}, pages = {6748 -- 6757}, year = {2023}, abstract = {This paper describes the potential for developing a digital twin of society- a dynamic model that can be used to observe, analyze, and predict the evolution of various societal aspects. Such a digital twin can help governmental agencies and policy makers in interpreting trends, understanding challenges, and making decisions regarding investments or policies necessary to support societal development and ensure future prosperity. The paper reviews related work regarding the digital twin paradigm and its applications. The paper presents a motivating case study- an analysis of opportunities and challenges faced by the German federal employment agency, Bundesagentur f¨ur Arbeit (BA), proposes solutions using digital twins, and describes initial proofs of concept for such solutions.}, language = {en} } @article{MolinnusDrinicIkenetal.2021, author = {Molinnus, Denise and Drinic, Aleksander and Iken, Heiko and Kr{\"o}ger, Nadja and Zinser, Max and Smeets, Ralf and K{\"o}pf, Marius and Kopp, Alexander and Sch{\"o}ning, Michael Josef}, title = {Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk}, series = {Biosensors and Bioelectronics}, volume = {183}, journal = {Biosensors and Bioelectronics}, number = {Art. 113204}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2021.113204}, year = {2021}, language = {en} } @article{FerreinDyllaLakemeyeretal.2005, author = {Ferrein, Alexander and Dylla, Frank and Lakemeyer, Gerhard and Murray, Jan}, title = {Towards a League-Independent Qualitative Soccer Theory for RoboCup / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard ; Murray, Jan ; Obst, Oliver ; R{\"o}fer, Thomas ; Stolzenburg, Frieder ; Visser, Ubbo}, series = {RoboCup 2004: Robot Soccer World Cup VIII / Daniele Nardi ... (ed.).}, journal = {RoboCup 2004: Robot Soccer World Cup VIII / Daniele Nardi ... (ed.).}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-25046-8}, pages = {611 -- 618}, year = {2005}, language = {en} } @inproceedings{EichenbaumNikolovskiMuelhensetal.2023, author = {Eichenbaum, Julian and Nikolovski, Gjorgji and M{\"u}lhens, Leon and Reke, Michael and Ferrein, Alexander and Scholl, Ingrid}, title = {Towards a lifelong mapping approach using Lanelet 2 for autonomous open-pit mine operations}, series = {2023 IEEE 19th International Conference on Automation Science and Engineering (CASE)}, booktitle = {2023 IEEE 19th International Conference on Automation Science and Engineering (CASE)}, publisher = {IEEE}, isbn = {979-8-3503-2069-5 (Online)}, doi = {10.1109/CASE56687.2023.10260526}, pages = {8 Seiten}, year = {2023}, abstract = {Autonomous agents require rich environment models for fulfilling their missions. High-definition maps are a well-established map format which allows for representing semantic information besides the usual geometric information of the environment. These are, for instance, road shapes, road markings, traffic signs or barriers. The geometric resolution of HD maps can be as precise as of centimetre level. In this paper, we report on our approach of using HD maps as a map representation for autonomous load-haul-dump vehicles in open-pit mining operations. As the mine undergoes constant change, we also need to constantly update the map. Therefore, we follow a lifelong mapping approach for updating the HD maps based on camera-based object detection and GPS data. We show our mapping algorithm based on the Lanelet 2 map format and show our integration with the navigation stack of the Robot Operating System. We present experimental results on our lifelong mapping approach from a real open-pit mine.}, language = {en} } @inproceedings{NeumannFerreinKallweitetal.2014, author = {Neumann, Tobias and Ferrein, Alexander and Kallweit, Stephan and Scholl, Ingrid}, title = {Towards a mobile mapping robot for underground mines}, series = {7th Conference of Robotics and Mechatronics : RobMech 2014 : 27th and 28th Nov. 2014, Cape Town}, booktitle = {7th Conference of Robotics and Mechatronics : RobMech 2014 : 27th and 28th Nov. 2014, Cape Town}, organization = {Conference of Robotics and Mechatronics <7, 2014, Cape Town, South Africa>}, pages = {1 -- 6}, year = {2014}, language = {en} } @article{MolinnusBegingLowisetal.2020, author = {Molinnus, Denise and Beging, Stefan and Lowis, Carsten and Sch{\"o}ning, Michael Josef}, title = {Towards a multi-enzyme capacitive field-effect biosensor by comparative study of drop-coating and nano-spotting technique}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {17}, publisher = {MDPI}, address = {Basel}, isbn = {1424-8220}, doi = {10.3390/s20174924}, pages = {Artikel 4942}, year = {2020}, abstract = {Multi-enzyme immobilization onto a capacitive field-effect biosensor by nano-spotting technique is presented. The nano-spotting technique allows to immobilize different enzymes simultaneously on the sensor surface with high spatial resolution without additional photolithographical patterning. The amount of applied enzymatic cocktail on the sensor surface can be tailored. Capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors with Ta2O5 as pH-sensitive transducer layer have been chosen to immobilize the three different (pL droplets) enzymes penicillinase, urease, and glucose oxidase. Nano-spotting immobilization is compared to conventional drop-coating method by defining different geometrical layouts on the sensor surface (fully, half-, and quarter-spotted). The drop diameter is varying between 84 µm and 102 µm, depending on the number of applied drops (1 to 4) per spot. For multi-analyte detection, penicillinase and urease are simultaneously nano-spotted on the EIS sensor. Sensor characterization was performed by C/V (capacitance/voltage) and ConCap (constant capacitance) measurements. Average penicillin, glucose, and urea sensitivities for the spotted enzymes were 81.7 mV/dec, 40.5 mV/dec, and 68.9 mV/dec, respectively.}, language = {en} } @article{ReisertGeisslerFloerkeetal.2011, author = {Reisert, Steffen and Geissler, Hanno and Fl{\"o}rke, Rudolf and N{\"a}ther, Niko and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Towards a multi-sensor system for the evaluation of aseptic processes employing hydrogen peroxide vapour (H2O2)}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1351 -- 1356}, year = {2011}, language = {en} } @inproceedings{BohrnStuetzFleischeretal.2012, author = {Bohrn, U. and St{\"u}tz, E. and Fleischer, M. and Sch{\"o}ning, Michael Josef and Wagner, P.}, title = {Towards a paradigm change - mammalian cells as sensitive biosensor layers for the detection of unexpected toxic substances in air}, series = {Nanoscale Science and Technology (NS\&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012}, booktitle = {Nanoscale Science and Technology (NS\&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012}, editor = {Abdelghani, Adnane and Sch{\"o}ning, Michael Josef}, pages = {44 -- 44}, year = {2012}, language = {en} } @article{GerhardsSkorupaSanderetal.2011, author = {Gerhards, M. and Skorupa, S. and Sander, Volker and Pfeiffer, P. and Belloum, A.}, title = {Towards a security framework for a WS-HumanTask processor}, series = {7th International Conference on Network and Service Management (CNSM), 2011 Paris}, journal = {7th International Conference on Network and Service Management (CNSM), 2011 Paris}, publisher = {IEEE}, address = {New York}, isbn = {978-3-901882-44-9}, pages = {1 -- 5}, year = {2011}, language = {en} }