@article{KuschRieserKnuppetal.2015,
  author    = {Kusch, Peter and Rieser, Claudia and Knupp, Gerd and Mang, Thomas},
  title     = {Characterization of copolymers of methacrylic acid with poly(ethylene glycol) methyl ether methacrylate macromonomers by analytical pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS)},
  series = {Journal of Analytical and Applied Pyrolysis},
  volume    = {Vol. 113},
  journal   = {Journal of Analytical and Applied Pyrolysis},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0165-2370},
  doi       = {10.1016/j.jaap.2015.03.003},
  pages     = {412 -- 418},
  year      = {2015},
  language  = {de}
}
@article{PilasIkenSelmeretal.2015,
  author    = {Pilas, Johanna and Iken, Heiko and Selmer, Thorsten and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Development of a multi-parameter sensor chip for the simultaneous detection of organic compounds in biogas processes},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431894},
  pages     = {1306 -- 1312},
  year      = {2015},
  abstract  = {An enzyme-based multi-parameter biosensor is developed for monitoring the concentration of formate, d-lactate, and l-lactate in biological samples. The sensor is based on the specific dehydrogenation by an oxidized β-nicotinamide adenine dinucleotide (NAD+)-dependent dehydrogenase (formate dehydrogenase, d-lactic dehydrogenase, and l-lactic dehydrogenase, respectively) in combination with a diaphorase from Clostridium kluyveri (EC 1.8.1.4). The enzymes are immobilized on a platinum working electrode by cross-linking with glutaraldehyde (GA). The principle of the determination scheme in case of l-lactate is as follows: l-lactic dehydrogenase (l-LDH) converts l-lactate into pyruvate by reaction with NAD+. In the presence of hexacyanoferrate(III), the resulting reduced β-nicotinamide adenine dinucleotide (NADH) is then regenerated enzymatically by diaphorase. The electrochemical detection is based on the current generated by oxidation of hexacyanoferrate(II) at an applied potential of +0.3 V vs. an Ag/AgCl reference electrode. The biosensor will be electrochemically characterized in terms of linear working range and sensitivity. Additionally, the successful practical application of the sensor is demonstrated in an extract from maize silage.},
  language  = {en}
}
@article{BreuerRaueKirschbaumetal.2015,
  author    = {Breuer, Lars and Raue, Markus and Kirschbaum, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten},
  title     = {Light-controllable polymeric material based on temperature-sensitive hydrogels with incorporated graphene oxide},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201431944},
  pages     = {1368 -- 1374},
  year      = {2015},
  abstract  = {Poly(N-isopropylacrylamide) (PNIPAAm) hydrogel films with incorporated graphene oxide (GO) were developed and tested as light-stimulated actuators. GO dispersions were synthesized via Hummers method and characterized toward their optical properties and photothermal energy conversion. The hydrogels were prepared by means of photopolymerization. In addition, the influence of GO within the hydrogel network on the lower critical solution temperature (LCST) was investigated by differential scanning calorimetry (DSC). The optical absorbance and the response to illumination were determined as a function of GO concentration for thin hydrogel films. A proof of principle for the stimulation with light was performed.},
  language  = {en}
}
@article{SchiffelsSelmer2015,
  author    = {Schiffels, Johannes and Selmer, Thorsten},
  title     = {A flexible toolbox to study protein-assisted metalloenzyme assembly in vitro},
  series = {Biotechnology and Bioengineering},
  volume    = {112},
  journal   = {Biotechnology and Bioengineering},
  number    = {11},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1097-0290},
  doi       = {10.1002/bit.25658},
  pages     = {2360 -- 2372},
  year      = {2015},
  language  = {en}
}
@article{VoigtAlbrechtSieversetal.2015,
  author    = {Voigt, Birgit and Albrecht, Dirk and Sievers, Susanne and Becher, D{\"o}rte and Bongaerts, Johannes and Evers, Stefan and Schweder, Thomas and Maurer, Karl-Heinz and Hecker, Michael},
  title     = {High-resolution proteome maps of Bacillus licheniformis cells growing in minimal medium},
  series = {Proteomics},
  volume    = {15},
  journal   = {Proteomics},
  number    = {15},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1615-9861},
  doi       = {10.1002/pmic.201400504},
  pages     = {2629 -- 2633},
  year      = {2015},
  language  = {en}
}
@article{MolinnusBaeckerSiegertetal.2015,
  author    = {Molinnus, Denise and B{\"a}cker, Matthias and Siegert, Petra and Willenberg, H. and Poghossian, Arshak and Keusgen, M. and Sch{\"o}ning, Michael Josef},
  title     = {Detection of Adrenaline Based on Substrate Recycling Amplification},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.708},
  pages     = {540 -- 543},
  year      = {2015},
  abstract  = {An amperometric enzyme biosensor has been applied for the detection of adrenaline. The adrenaline biosensor has been prepared by modification of an oxygen electrode with the enzyme laccase that operates at a broad pH range between pH 3.5 to pH 8. The enzyme molecules were immobilized via cross-linking with glutaraldehyde. The sensitivity of the developed adrenaline biosensor in different pH buffer solutions has been studied.},
  language  = {en}
}
@article{PilasMarianoKeusgenetal.2015,
  author    = {Pilas, Johanna and Mariano, K. and Keusgen, M. and Selmer, Thorsten and Sch{\"o}ning, Michael Josef},
  title     = {Optimization of an Enzyme-based Multi-parameter Biosensor for Monitoring Biogas Processes},
  series = {Procedia Engineering},
  volume    = {120},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2015.08.702},
  pages     = {532 -- 535},
  year      = {2015},
  language  = {en}
}
@article{TakenagaSchneiderErbayetal.2015,
  author    = {Takenaga, Shoko and Schneider, Benno and Erbay, E. and Biselli, Manfred and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef and Wagner, Torsten},
  title     = {Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process},
  series = {Physica status solidi (a)},
  volume    = {212},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201532053},
  pages     = {1347 -- 1352},
  year      = {2015},
  abstract  = {A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.},
  language  = {en}
}
@inproceedings{SrivastavaKnolleSchnugetal.2015,
  author    = {Srivastava, Alok and Knolle, F. and Schnug, E. and Scherer, Ulrich W.},
  title     = {Study of Trace Elements in Water Bodies of the Harz Mts. Region, Germany using Total Reflection X Ray Fluorescence (TXRF)},
  series = {DAE-BRNS 12th National Symposium on Nuclear and Radiochemistry NUCAR 2015, Feb. 9-13, Mumbai, India, Mumbai, India; 02/2015},
  booktitle = {DAE-BRNS 12th National Symposium on Nuclear and Radiochemistry NUCAR 2015, Feb. 9-13, Mumbai, India, Mumbai, India; 02/2015},
  pages     = {355 -- 356},
  year      = {2015},
  language  = {de}
}
@incollection{SrivastavaKnolleHoyleretal.2015,
  author    = {Srivastava, Alok and Knolle, Friedhart and Hoyler, Friedrich and Scherer, Ulrich W. and Schnug, Ewald},
  title     = {Uranium Toxicity in the State of Punjab in North-Western India},
  series = {Management of Natural Resources in a Changing Environment},
  booktitle = {Management of Natural Resources in a Changing Environment},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-12559-6},
  doi       = {10.1007/978-3-319-12559-6_21},
  pages     = {271 -- 275},
  year      = {2015},
  abstract  = {Lately there has been an increasing concern about uranium toxicity in some districts of Punjab State located in the North Western part of India after the publication of a report (Blaurock-Busch et al. 2010) which showed that the concentration of uranium in hair and urine of children suffering from physical deformities, neurological and mental disorder from Malwa region (Fig. 1) of Punjab State was manifold higher than the reference ranges. A train which connects the affected region with the nearby city of Bikaner which has a Cancer Hospital has been nicknamed as Cancer Express due to the frenzy generated on account of uranium related toxicity.},
  language  = {en}
}
@article{CehreliAkpinarTemizArtmannetal.2015,
  author    = {Cehreli, Ruksan and Akpinar, Hale and Temiz Artmann, Ayseg{\"u}l and Sagol, Ozgul},
  title     = {Effects of Glutamine and Omega-3 Fatty Acids on Erythrocyte Deformability and Oxidative Damage in Rat Model of Enterocolitis},
  series = {Gastroenterology Research},
  volume    = {8},
  journal   = {Gastroenterology Research},
  number    = {5},
  issn      = {1918-2813},
  doi       = {10.14740/gr683w},
  pages     = {265 -- 273},
  year      = {2015},
  language  = {en}
}
@inproceedings{BreuerRaueMangetal.2015,
  author    = {Breuer, Lars and Raue, Markus and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, Ronald and Wagner, Torsten},
  title     = {Light-stimulated hydrogel actuators with incorporated graphene oxide for microfluidic applications},
  series = {12. Dresdner Sensor-Symposium 2015},
  booktitle = {12. Dresdner Sensor-Symposium 2015},
  doi       = {10.5162/12dss2015/P5.8},
  pages     = {206 -- 209},
  year      = {2015},
  language  = {en}
}
@book{MuellerRath2015,
  author    = {M{\"u}ller, Bodo and Rath, Walter},
  title     = {Formulierung von Kleb- und Dichtstoffen: das kompetente Lehrbuch f{\"u}r Studium und Praxis},
  edition   = {3., vollst. {\"u}berarb. Aufl.},
  publisher = {Vincentz Network},
  address   = {Hannover},
  isbn      = {978-3-86630-605-9},
  pages     = {375 S. : Ill., graph. Darst},
  year      = {2015},
  language  = {de}
}
@book{LauthKowalczyk2015,
  author    = {Lauth, Jakob and Kowalczyk, J{\"u}rgen},
  title     = {Thermodynamik : eine Einf{\"u}hrung},
  publisher = {Springer Spektrum},
  address   = {Berlin},
  isbn      = {978-3-662-46228-7},
  doi       = {10.1007/978-3-662-46229-4},
  pages     = {XVIII, 380 S.: Ill., graph. Darst.},
  year      = {2015},
  language  = {de}
}
@article{AlKaidyDuweHusteretal.2015,
  author    = {Al-Kaidy, Huschyar and Duwe, Anna and Huster, Manuel and Muffler, Kai and Schlegel, Christin and Tim, Sieker and Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Biotechnology and bioprocess engineering - from the first ullmann's article to recent trends},
  series = {ChemBioEng Reviews},
  volume    = {2},
  journal   = {ChemBioEng Reviews},
  number    = {3},
  publisher = {Wiley},
  address   = {Weinheim},
  doi       = {10.1002/cben.201500008},
  pages     = {175 -- 184},
  year      = {2015},
  abstract  = {For several thousand years, biotechnology and its associated technical processes have had a great impact on the development of mankind. Based on empirical methods, in particular for the production of foodstuffs and daily commodities, these disciplines have become one of the most innovative future issues. Due to the increasing detailed understanding of cellular processes, production strains can now be optimized. In combination with modern bioprocesses, a variety of bulk and fine chemicals as well as pharmaceuticals can be produced efficiently. In this article, some of the current trends in biotechnology are discussed.},
  language  = {en}
}
@article{ThielMufflerTippkoetteretal.2015,
  author    = {Thiel, Alexander and Muffler, Kai and Tippk{\"o}tter, Nils and Suck, Kirstin and Sohling, Ulrich and Hruschka, Steffen M. and Ulber, Roland},
  title     = {A novel integrated downstream processing approach to recover sinapic acid, phytic acid and proteins from rapeseed meal},
  series = {Journal of Chemical Technology and Biotechnology},
  volume    = {90},
  journal   = {Journal of Chemical Technology and Biotechnology},
  number    = {11},
  publisher = {Wiley},
  address   = {Weinheim},
  doi       = {10.1002/jctb.4664},
  pages     = {1999 -- 2006},
  year      = {2015},
  abstract  = {BACKGROUND Currently, several techniques exist for the downstream processing of protein, phytic acid and sinapic acid from rapeseed and rapeseed meal, but no technique has been developed to separate all of the components in one process. In this work, two new downstream processing strategies focusing on recovering sinapic acid, phytic acid and protein from rapeseed meal were established. RESULTS The sinapic acid content was enhanced by a factor of 4.5 with one method and 5.1 with the other. The isolation of sinapic acid was accomplished using a zeolite-based adsorbent with high adsorptive and optimal desorption characteristics. Phytic acid was isolated using the anion-exchange resin Purolite A200®. In addition, the processes resulted in two separated protein fractions. The ratios of globulin and albumin ratio to the total protein were 59.2\% and 40.1\%, respectively. The steps were then combined in two different ways: (a) a 'sequential process' using the zeolite and A200 in batch processes; and (b) a 'parallel process' using only A200 in a chromatographic system to separate all of the compounds. CONCLUSIONS It can be concluded that isolation of all three components was possible in both processes. These could enhance the added value of current processes using rapeseed meal as a protein source. © 2015 Society of Chemical Industry},
  language  = {en}
}
@article{SchumannRoginSchneideretal.2015,
  author    = {Schumann, Christiane and Rogin, Sabine and Schneider, Horst and Tippk{\"o}tter, Nils and Oster, J{\"u}rgen and Kampeis, Percy},
  title     = {Simultane Atline-Quantifizierung von Magnetpartikeln und Mikroorganismen bei einer HGMS-Filtration},
  series = {Chemie Ingenieur Technik},
  volume    = {87},
  journal   = {Chemie Ingenieur Technik},
  number    = {1-2},
  doi       = {10.1002/cite.201300158},
  pages     = {137 -- 149},
  year      = {2015},
  abstract  = {Es wird eine neue Atline-Messmethode vorgestellt, mit der w{\"a}hrend einer Hochgradienten-Magnetseparation (HGMS)-Filtration eine simultane Quantifizierung von Magnetpartikeln und Mikroorganismen im Filtrat vorgenommen werden kann. Dabei gelingt die Quantifizierung signifikant besser als mit bisher verwendeten Messmethoden. Mit dieser Methode ist es m{\"o}glich, die Trennleistung einer HGMS-Filtration zu bestimmen und einen Filterdurchbruch durch Konzentrationsanstiege im Bereich einiger µg L-1 von Magnetpartikeln im Filtrat fr{\"u}hzeitig zu detektieren, ohne dass nennenswerte Partikelmengen verloren gehen.},
  language  = {de}
}
@article{ThielMufflerTippkoetteretal.2015,
  author    = {Thiel, Alexander and Muffler, Kai and Tippk{\"o}tter, Nils and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland},
  title     = {Aufarbeitung von Polyphenolen aus Weizen mittels Zeolithen am Beispiel der Ferulas{\"a}ure},
  series = {Chemie IngenieurTechnik},
  volume    = {87},
  journal   = {Chemie IngenieurTechnik},
  number    = {1-2},
  publisher = {Wiley},
  address   = {Weinheim},
  doi       = {10.1002/cite.201400031},
  pages     = {128 -- 136},
  year      = {2015},
  abstract  = {Aufarbeitung von Polyphenolen aus Weizenmittels Zeolithen am Beispiel der Ferulasa¨ ureAlexander Thiel1, Kai Muffler1, Nils Tippko¨ tter1, Kirstin Suck2, Ulrich Sohling2, Friedrich Ruf3und Roland Ulber1,*DOI: 10.1002/cite.201400031Bei der Ferulasa¨ure handelt es sich um einen Wertstoff, der aus Weizen gewonnen und in der Lebensmittel- und Pharma-industrie eingesetzt werden kann. Der Einsatz von Weizen als nachwachsende Rohstoffquelle ist allerdings nur dann wirt-schaftlich durchfu¨hrbar, wenn eine Prozessintegration in die bestehenden industriellen Verfahren gewa¨hrleistet oder einedirekte Konkurrenz zur Mehl- und Sta¨rkeindustrie vermieden werden kann. In diesem Artikel wird ein Verfahren aufge-zeigt, welches hohe Ausbeuten ermo¨glicht und eine Konkurrenz zu bestehenden Verwertungspfaden vermeidet.},
  language  = {de}
}
@article{WiesenTippkoetterMuffleretal.2015,
  author    = {Wiesen, Sebastian and Tippk{\"o}tter, Nils and Muffler, Kai and Suck, Kirstin and Sohling, Ulrich and Ruf, Friedrich and Ulber, Roland},
  title     = {Adsorption of fatty acids to layered double hydroxides in aqueous systems},
  series = {Adsorption},
  volume    = {21},
  journal   = {Adsorption},
  number    = {6-7},
  publisher = {Springer},
  address   = {Berlin},
  pages     = {459 -- 466},
  year      = {2015},
  abstract  = {Due to their anion exchange characteristics, layered double hydroxides (LDHs) are suitable for the detoxification of aqueous, fatty acid containing fermentation substrates. The aim of this study is to examine the adsorption mechanism, using crude glycerol from plant oil esterification as a model system. Changes in the intercalation structure in relation to the amount of fatty acids adsorbed are monitored by X-ray diffraction and infra-red spectroscopy. Additionally, calcination of LDH is investigated in order to increase the binding capacity for fatty acids. Our data propose that, at ambient temperature, fatty acids can be bound to the hydrotalcite by adsorption or in addition by intercalation, depending on fatty acid concentration. The adsorption of fatty acids from crude glycerol shows a BET-like behavior. Above a fatty acid concentration of 3.5 g L-1, intercalation of fatty acids can be shown by the appearance of an increased interlayer spacing. This observation suggests a two phase adsorption process. Calcination of LDHs allows increasing the binding capacity for fatty acids by more than six times, mainly by reduction of structural CO32-.},
  language  = {en}
}
@article{PaulssenHoehrHouetal.2015,
  author    = {Paulßen, Elisabeth and Hoehr, Cornelia and Hou, Xinchi and Hanemaayer, Victoire and Zeisler, Stefan and Adam, Michael J. and Ruth, Thomas J. and Celler, Anna and Buckley, Ken and Benard, Francois and Schaffer, Paul},
  title     = {Production of Y-86 and other radiometals for research purposes using a solution target system},
  series = {Nuclear medicine and biology},
  volume    = {42},
  journal   = {Nuclear medicine and biology},
  number    = {11},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9614},
  doi       = {10.1016/j.nucmedbio.2015.06.005},
  pages     = {842 -- 849},
  year      = {2015},
  language  = {en}
}
@article{ScheerKapelyukhRodeetal.2015,
  author    = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Oswald, Stefan and Busch, Diana and Mclaughlin, Lesley A. and Lin, De and Henderson, Colin J. and Wolf, C. Roland},
  title     = {Defining Human Pathways of Drug Metabolism In Vivo through the Development of a Multiple Humanized Mouse Model},
  series = {Drug Metabolism and Disposition},
  volume    = {43},
  journal   = {Drug Metabolism and Disposition},
  number    = {11},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-009x},
  doi       = {10.1124/dmd.115.065656},
  pages     = {1679 -- 1690},
  year      = {2015},
  language  = {en}
}
@article{HoughNalwalkDingetal.2015,
  author    = {Hough, Lindsay B. and Nalwalk, Julia W. and Ding, Xinxin and Scheer, Nico},
  title     = {Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms},
  series = {Drug Metabolism and Disposition},
  volume    = {43},
  journal   = {Drug Metabolism and Disposition},
  number    = {9},
  issn      = {1521-009x},
  doi       = {10.1124/dmd.115.065490},
  pages     = {1326 -- 1330},
  year      = {2015},
  language  = {en}
}
@article{HendersonMclaughlinScheeretal.2015,
  author    = {Henderson, Colin J. and Mclaughlin, Lesley A. and Scheer, Nico and Stanley, Lesley A. and Wolf, C. Roland},
  title     = {Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo s},
  series = {Molecular Pharmacology},
  volume    = {87},
  journal   = {Molecular Pharmacology},
  number    = {4},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-0111},
  doi       = {10.1124/mol.114.097394},
  pages     = {733 -- 739},
  year      = {2015},
  language  = {en}
}
@incollection{WolfKapelyukhScheeretal.2015,
  author    = {Wolf, C. Roland and Kapelyukh, Yury and Scheer, Nico and Henderson, Colin J.},
  title     = {Application of Humanised and Other Transgenic Models to Predict Human Responses to Drugs},
  editor    = {Wilson, Alan G. E.},
  publisher = {RSC Publ.},
  address   = {Cambridge},
  isbn      = {978-1-78262-778-4},
  doi       = {10.1039/9781782622376-00152},
  pages     = {152 -- 176},
  year      = {2015},
  abstract  = {The use of transgenic animal models has transformed our knowledge of complex biochemical pathways in vivo. It has allowed disease processes to be modelled and used in the development of new disease prevention and treatment strategies. They can also be used to define cell- and tissue-specific pathways of gene regulation. A further major application is in the area of preclinical development where such models can be used to define pathways of chemical toxicity, and the pathways that regulate drug disposition. One major application of this approach is the humanisation of mice for the proteins that control drug metabolism and disposition. Such models can have numerous applications in the development of drugs and in their more sophisticated use in the clinic.},
  language  = {en}
}
@article{HagerHentschkeHojdisetal.2015,
  author    = {Hager, Jonathan and Hentschke, Reinhard and Hojdis, Nils and Karimi-Varzaneh, Hossein Ali},
  title     = {Computer Simulation of Particle-Particle Interaction in a Model Polymer Nanocomposite},
  series = {Macromolecules},
  volume    = {48},
  journal   = {Macromolecules},
  number    = {24},
  issn      = {1520-5835},
  doi       = {10.1021/acs.macromol.5b01864},
  pages     = {9039 -- 9049},
  year      = {2015},
  language  = {en}
}
@inproceedings{WulfhorstMerseburgTippkoetter2015,
  author    = {Wulfhorst, Helene and Merseburg, Johannes and Tippk{\"o}tter, Nils},
  title     = {Analyse von Lignocellulose mittels dynamischer Differenzkalorimetrie und Infrarot - Spektrometrie},
  series = {12. Dresdner Sensor-Symposium 2015 2015-12-07 - 2015-12-09},
  booktitle = {12. Dresdner Sensor-Symposium 2015 2015-12-07 - 2015-12-09},
  isbn      = {978-3-9813484-9-1},
  doi       = {10.5162/12dss2015/P6.2},
  pages     = {210 -- 215},
  year      = {2015},
  language  = {de}
}
@misc{StadtmuellerTippkoetterUlber2015,
  author    = {Stadtm{\"u}ller, Ralf and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Method for production of single-stranded macronucleotides},
  year      = {2015},
  abstract  = {The invention relates to a method for production of single-stranded macronucleotides by amplifying and ligating an extended monomeric single-stranded target nucleic acid sequence (targetss) into a repetitive cluster of double-stranded target nucleic acid sequences (targetds), and subsequently cloning the construct into a vector (aptagene vector). The aptagene vector is transformed into host cells for replication of the aptagene and isolated in order to optain single-stranded target sequences (targetss). The invention also relates to single-stranded nucleic acids, produced by a method of the invention.},
  language  = {en}
}
@misc{HuschyarTippkoetterUlber2015,
  author    = {Huschyar, Al-Kaidy and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {System und Verfahren zur Durchf{\"u}hrung von chemischen, biologischen oder physikalischen Reaktionen},
  year      = {2015},
  language  = {de}
}
@article{BreuerRaueStrobeletal.2016,
  author    = {Breuer, Lars and Raue, Markus and Strobel, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten},
  title     = {Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems},
  series = {Physica status solidi (a)},
  volume    = {213},
  journal   = {Physica status solidi (a)},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6300},
  doi       = {10.1002/pssa.201533056},
  pages     = {1520 -- 1525},
  year      = {2016},
  abstract  = {Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.},
  language  = {en}
}
@inproceedings{KasperSchiffelsKrafftetal.2016,
  author    = {Kasper, Katharina and Schiffels, Johannes and Krafft, Simone and Kuperjans, Isabel and Elbers, Gereon and Selmer, Thorsten},
  title     = {Biogas Production on Demand Regulated by Butyric Acid Addition},
  series = {IOP Conference Series: Earth and Environmental Science. Bd. 32},
  volume    = {32},
  booktitle = {IOP Conference Series: Earth and Environmental Science. Bd. 32},
  issn      = {1755-1315},
  doi       = {10.1088/1755-1315/32/1/012009},
  pages     = {012009/1 -- 012009/4},
  year      = {2016},
  language  = {en}
}
@article{NiedermeyerZhouDursunetal.2016,
  author    = {Niedermeyer, Angela and Zhou, Bei and Dursun, G{\"o}zde and Temiz Artmann, Ayseg{\"u}l and Markert, Bernd},
  title     = {An examination of tissue engineered scaffolds in a bioreactor},
  series = {Proceedings in Applied Mathematics and Mechanics PAMM},
  volume    = {16},
  journal   = {Proceedings in Applied Mathematics and Mechanics PAMM},
  number    = {1},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1617-7061},
  doi       = {10.1002/pamm.201610038},
  pages     = {99 -- 100},
  year      = {2016},
  abstract  = {Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated.},
  language  = {en}
}
@article{PinkenburgSchiffelsSelmer2016,
  author    = {Pinkenburg, Olaf and Schiffels, Johannes and Selmer, Thorsten},
  title     = {Das CoLibry-Konzept - ein Werkzeugkasten f{\"u}r die Synthetische Biologie: Bioproduktion},
  series = {BIOspektrum},
  volume    = {22},
  journal   = {BIOspektrum},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  doi       = {10.1007/s12268-016-0734-8},
  pages     = {593 -- 595},
  year      = {2016},
  abstract  = {Regardless of size or destination, synthetic biology starts with com-parably small information units, which need to be combined and properly arranged in order to achieve a certain goal. This may be the de novo synthesis of individual genes from oligonucleotides, a shuffling of protein domains in order to create novel biocatalysts, the assembly of multiple enzyme encoding genes in metabolic pathway design, or strain development at the production stage. The CoLibry concept has been designed in order to close the gap between recombinant production of individual genes and genome editing.},
  language  = {de}
}
@article{HeinzeMangPopescuetal.2016,
  author    = {Heinze, D. and Mang, Thomas and Popescu, C. and Weichold, O.},
  title     = {Effect of side chain length and degree of polymerization on the decomposition and crystallization behaviour of chlorinated poly(vinyl ester) oligomers},
  series = {Thermochimica Acta},
  volume    = {637},
  journal   = {Thermochimica Acta},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0040-6031 (electronic)},
  doi       = {10.1016/j.tca.2016.05.015},
  pages     = {143 -- 153},
  year      = {2016},
  abstract  = {Four members of a homologous series of chlorinated poly(vinyl ester) oligomers CCl₃-(CH₂CH (OCO(CH₂)ₘCH₃))ₙ-Cl with degrees of polymerization of 10 and 20 were prepared by telomerisation using carbon tetrachloride. The number of side chain carbon atoms ranges from 2 (poly(vinyl acetate) to 18 (poly(vinyl stearate)). The effect of the n-alkyl side chain length and of the degree of polymerization on the thermal stability and crystallization behaviour of the synthesized compounds was investigated. All oligomers degrade in two major steps by first losing HCl and side chains with subsequent breakdown of the backbone. The members with short side chains, up to poly(vinyl octanoate), are amorphous and show internal plasticization, whereas those with high number of side chain carbon atoms are semi-crystalline due to side-chain crystallization. A better packing for poly(vinyl stearate) is also noticeable. The glass transition and melting temperatures as well as the onset temperature of decomposition are influenced to a larger extent by the side chain length than by the degree of polymerization. Thermal stability is improved if both the size and number of side chains increase, but only a long side chain causes a significant increase of the resistance to degradation. This results in a stabilization of PVAc so that oligomers from poly(vinyl octanoate) on are stable under atmospheric conditions. Thus, the way to design stable, chlorinated PVEs oligomers is to use a long n-alkyl side chain.},
  language  = {en}
}
@book{Feuerriegel2016,
  author    = {Feuerriegel, Uwe},
  title     = {Verfahrenstechnik mit EXCEL: Verfahrenstechnische Berechnungen effektiv durchf{\"u}hren und professionell dokumentieren},
  publisher = {Springer Fachmedien},
  address   = {Wiesbaden},
  isbn      = {978-3-658-02902-9},
  doi       = {10.1007/978-3-658-02903-6},
  pages     = {XVII, 381 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 5: Elektrochemie},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47559-1},
  pages     = {55 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 4: Reaktionskinetik},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47674-1},
  pages     = {52 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 3: Phasengleichgewichte},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47571-3},
  pages     = {57 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 2: Chemische Thermodynamik},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47621-5},
  pages     = {77 Seiten},
  year      = {2016},
  language  = {de}
}
@book{Lauth2016,
  author    = {Lauth, Jakob},
  title     = {Physikalische Chemie, 1: Grundlagen der Thermodynamik und Verhalten der Gase},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47676-5},
  pages     = {57 Seiten},
  year      = {2016},
  language  = {de}
}
@book{LauthKowalczyk2016,
  author    = {Lauth, Jakob and Kowalczyk, J{\"u}rgen},
  title     = {Einf{\"u}hrung in die Physik und Chemie der Grenzfl{\"a}chen und Kolloide},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {978-3-662-47018-3},
  doi       = {10.1007/978-3-662-47018-3},
  pages     = {Online-Ressource (XIX, 522 S., 341 Abb.)},
  year      = {2016},
  language  = {de}
}
@article{MolinnusSorichBartzetal.2016,
  author    = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate},
  series = {Sensors and Actuators B: Chemical},
  volume    = {237},
  journal   = {Sensors and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2016.06.064},
  pages     = {190 -- 195},
  year      = {2016},
  abstract  = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.},
  language  = {en}
}
@article{GhoschBaierSchuetzetal.2016,
  author    = {Ghosch, S. and Baier, M. and Sch{\"u}tz, J. and Schneider, Felix and Scherer, Ulrich W.},
  title     = {Analysis of electronic autoradiographs by mathematical post-processing},
  series = {Radiation Effects and Defects in Solids: Incorporating plasma science and plasma technology},
  volume    = {171},
  journal   = {Radiation Effects and Defects in Solids: Incorporating plasma science and plasma technology},
  number    = {1-2},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1029-4953},
  doi       = {10.1080/10420150.2016.1155587},
  pages     = {161 -- 172},
  year      = {2016},
  abstract  = {Autoradiography is a well-established method of nuclear imaging. When different radionuclides are present simultaneously, additional processing is needed to distinguish distributions of radionuclides. In this work, a method is presented where aluminium absorbers of different thickness are used to produce images with different cut-off energies. By subtracting images pixel-by-pixel one can generate images representing certain ranges of β-particle energies. The method is applied to the measurement of irradiated reactor graphite samples containing several radionuclides to determine the spatial distribution of these radionuclides within pre-defined energy windows. The process was repeated under fixed parameters after thermal treatment of the samples. The greyscale images of the distribution after treatment were subtracted from the corresponding pre-treatment images. Significant changes in the intensity and distribution of radionuclides could be observed in some samples. Due to the thermal treatment parameters the most significant differences were observed in the ³H and ¹⁴C inventory and distribution.},
  language  = {en}
}
@article{RoeschKratzHeringetal.2016,
  author    = {R{\"o}sch, C. and Kratz, F. and Hering, T. and Trautmann, S. and Umanskaya, N. and Tippk{\"o}tter, Nils and M{\"u}ller-Renno, C.M. and Ulber, R. and Hannig, M. and Ziegler, C.},
  title     = {Albumin-lysozyme interactions: cooperative adsorption on titanium and enzymatic activity},
  series = {Colloids and Surfaces B: Biointerfaces},
  volume    = {149},
  journal   = {Colloids and Surfaces B: Biointerfaces},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.colsurfb.2016.09.048},
  pages     = {115 -- 121},
  year      = {2016},
  abstract  = {The interplay of albumin (BSA) and lysozyme (LYZ) adsorbed simultaneously on titanium was analyzed by gel electrophoresis and BCA assay. It was found that BSA and lysozyme adsorb cooperatively. Additionally, the isoelectric point of the respective protein influences the adsorption. Also, the enzymatic activity of lysozyme and amylase (AMY) in mixtures with BSA was considered with respect to a possible influence of protein-protein interaction on enzyme activity. Indeed, an increase of lysozyme activity in the presence of BSA could be observed. In contrast, BSA does not influence the activity of amylase.},
  language  = {en}
}
@article{RothTippkoetter2016,
  author    = {Roth, Jasmine and Tippk{\"o}tter, Nils},
  title     = {Evaluation of lignocellulosic material for butanol production using enzymatic hydrolysate medium},
  series = {Cellulose Chemistry and Technology},
  volume    = {50},
  journal   = {Cellulose Chemistry and Technology},
  number    = {3-4},
  publisher = {Editura Academiei Romane},
  address   = {Bukarest},
  pages     = {405 -- 410},
  year      = {2016},
  abstract  = {Butanol is a promising gasoline additive and platform chemical that can be readily produced via acetone-butanolethanol (ABE) fermentation from pretreated lignocellulosic materials. This article examines lignocellulosic material from beech wood for ABE fermentation, using Clostridium acetobutylicum. First, the utilization of both C₅₋ (xylose) and C₆₋ (glucose) sugars as sole carbon source was investigated in static cultivation, using serum bottles and synthetic medium. The utilization of pentose sugar resulted in a solvent yield of 0.231 g·g_sugar⁻¹, compared to 0.262 g·g_sugar⁻¹ using hexose. Then, the Organosolv pretreated crude cellulose fibers (CF) were enzymatically decomposed, and the resulting hydrolysate medium was analyzed for inhibiting compounds (furans, organic acids, phenolics) and treated with ionexchangers for detoxification. Batch fermentation in a bioreactor using CF hydrolysate medium resulted in a total solvent yield of 0.20 gABE·g_sugar⁻¹.},
  language  = {en}
}
@article{AlKaidyTippkoetter2016,
  author    = {Al-Kaidy, Huschyar and Tippk{\"o}tter, Nils},
  title     = {Superparamagnetic hydrophobic particles as shell material for digital microfluidic droplets and proof-of-principle reaction assessments with immobilized laccase},
  series = {Engineering in Life Sciences},
  volume    = {16},
  journal   = {Engineering in Life Sciences},
  number    = {3},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  doi       = {10.1002/elsc.201400124},
  pages     = {222 -- 230},
  year      = {2016},
  abstract  = {In the field of biotechnology and molecular biology, the use of small liquid volumes has significant advantages. In particular, screening and optimization runs with acceptable amounts of expensive and hardly available catalysts, reagents, or biomolecules are feasible with microfluidic technologies. The presented new microfluidic system is based on the inclusion of small liquid volumes by a protective shell of magnetizable microparticles. Hereby, discrete aqueous microreactor drops with volumes of 1-30 μL can be formed on a simple planar surface. A digital movement and manipulation of the microreactor is performed by overlapping magnetic forces. The magnetic forces are generated by an electrical coil matrix positioned below a glass plate. With the new platform technology, several discrete reaction compartments can be moved simultaneously on one surface. Due to the magnetic fields, the reactors can even be merged to initiate reactions by mixing or positioned above surface-immobilized catalysts and then opened by magnetic force. Comparative synthesis routes of the magnetizable shell particles and superhydrophobic glass slides including their performance and stability with the reaction platform are described. The influence of diffusive mass transport during the catalyzed reaction is discussed by evaluation finite element model of the microreactor. Furthermore, a first model dye reaction of the enzyme laccase has been established.},
  language  = {en}
}
@incollection{Tippkoetter2016,
  author    = {Tippk{\"o}tter, Nils},
  title     = {Grundlagen der bio-chemischen Umwandlung},
  series = {Energie aus Biomasse : Grundlagen, Techniken und Verfahren},
  booktitle = {Energie aus Biomasse : Grundlagen, Techniken und Verfahren},
  editor    = {Kaltschmidt, Martin},
  edition   = {3., aktualisierte, erweiterte Auflage},
  publisher = {Springer Vieweg},
  address   = {Berlin ; Heidelberg},
  isbn      = {978-3-662-47437-2 (Print)},
  doi       = {10.1007/978-3-662-47438-9},
  pages     = {1447 -- 1500},
  year      = {2016},
  language  = {de}
}
@article{AlKaidyKuthanHeringetal.2016,
  author    = {Al-Kaidy, Huschyar and Kuthan, Kai and Hering, Thomas and Tippk{\"o}tter, Nils},
  title     = {Aqueous droplets used as enzymatic microreactors and their electromagnetic actuation},
  series = {Journal of Visualized Experiments},
  journal   = {Journal of Visualized Experiments},
  number    = {Issue 126},
  issn      = {1940-087X},
  doi       = {10.3791/54643},
  year      = {2016},
  abstract  = {For the successful implementation of microfluidic reaction systems, such as PCR and electrophoresis, the movement of small liquid volumes is essential. In conventional lab-on-a-chip-platforms, solvents and samples are passed through defined microfluidic channels with complex flow control installations. The droplet actuation platform presented here is a promising alternative. With it, it is possible to move a liquid drop (microreactor) on a planar surface of a reaction platform (lab-in-a-drop). The actuation of microreactors on the hydrophobic surface of the platform is based on the use of magnetic forces acting on the outer shell of the liquid drops which is made of a thin layer of superhydrophobic magnetite particles. The hydrophobic surface of the platform is needed to avoid any contact between the liquid core and the surface to allow a smooth movement of the microreactor. On the platform, one or more microreactors with volumes of 10 µL can be positioned and moved simultaneously. The platform itself consists of a 3 x 3 matrix of electrical double coils which accommodate either neodymium or iron cores. The magnetic field gradients are automatically controlled. By variation of the magnetic field gradients, the microreactors' magnetic hydrophobic shell can be manipulated automatically to move the microreactor or open the shell reversibly. Reactions of substrates and corresponding enzymes can be initiated by merging the microreactors or bringing them into contact with surface immobilized catalysts.},
  language  = {en}
}
@article{WulfhorstDuweMerseburgetal.2016,
  author    = {Wulfhorst, Helene and Duwe, Anna-Maria and Merseburg, Johannes and Tippk{\"o}tter, Nils},
  title     = {Compositional analysis of pretreated (beech) wood using differential scanning calorimetry and multivariate data analysis},
  series = {Tetrahedron},
  volume    = {72},
  journal   = {Tetrahedron},
  number    = {46},
  publisher = {Elsevier},
  address   = {Amsterdam},
  doi       = {10.1016/j.tet.2016.04.029},
  pages     = {7329 -- 7334},
  year      = {2016},
  abstract  = {The composition of plant biomass varies depending on the feedstock and pre-treatment conditions and influences its processing in biorefineries. In order to ensure optimal process conditions, the quantitative proportion of the main polymeric components of the pre-treated biomass has to be determined. Current standard procedures for biomass compositional analysis are complex, the measurements are afflicted with errors and therefore often not comparable. Hence, new powerful analytical methods are urgently required to characterize biomass. In this contribution, Differential Scanning Calorimetry (DSC) was applied in combination with multivariate data analysis (MVA) to detect the cellulose content of the plant biomass pretreated by Liquid Hot Water (LHW) and Organosolv processes under various conditions. Unlike conventional techniques, the developed analytic method enables the accurate quantification of monosaccharide content of the plant biomass without any previous sample preparation. It is easy to handle and avoids errors in sample preparation.},
  language  = {en}
}
@inproceedings{EngelThieringerTippkoetter2016,
  author    = {Engel, M. and Thieringer, J. and Tippk{\"o}tter, Nils},
  title     = {Microbial electrosynthesis for sustainable biobutanol production},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {77 -- 78},
  year      = {2016},
  language  = {en}
}
@inproceedings{HeringUlberTippkoetter2016,
  author    = {Hering, T. and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Development of a screening system for antimicrobial surfaces},
  series = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  booktitle = {New frontiers of biotech-processes (Himmelfahrtstagung) : 02-04 May 2016, Rhein-Mosel-Halle, Koblenz/Germany},
  publisher = {DECHEMA},
  address   = {Frankfurt am Main},
  pages     = {129},
  year      = {2016},
  language  = {en}
}