@article{FunkeBoernerRobinsonetal.2010,
  author    = {Funke, Harald and B{\"o}rner, Sebastian and Robinson, A. and Hendrick, P. and Recker, E.},
  title     = {Low NOx H2 combustion for industrial gas turbines of various power ranges},
  series = {5th International Gas Turbine Conference ETN-IGTC, ETN-2010-42, Brussels, Belgium, October 2010},
  journal   = {5th International Gas Turbine Conference ETN-IGTC, ETN-2010-42, Brussels, Belgium, October 2010},
  year      = {2010},
  language  = {en}
}
@article{ReckerBosschaertsWagemakersetal.2010,
  author    = {Recker, Elmar and Bosschaerts, Walter and Wagemakers, Rolf and Hendrick, Patrick and Funke, Harald and B{\"o}rner, Sebastian},
  title     = {Experimental study of a round jet in cross-flow at low momentum ratio},
  series = {15th International Symposium on Applications of Laser Techniques to Fluid Mechanics Lisbon, Portugal, 05-08 July, 2010 - 1},
  journal   = {15th International Symposium on Applications of Laser Techniques to Fluid Mechanics Lisbon, Portugal, 05-08 July, 2010 - 1},
  pages     = {1 -- 13},
  year      = {2010},
  language  = {en}
}
@article{HeinzelSchaeferMuelleretal.2010,
  author    = {Heinzel, Alexander and Sch{\"a}fer, Ralf and M{\"u}ller, Hans-Wilhelm and Schieffer, Andre and Ingenhag, Ariane and Eickhoff, Simon B. and Northoff, Georg and Franz, Matthias and Hautzel, Hubertus},
  title     = {Increased Activation of the Supragenual Anterior Cingulate Cortex during Visual Emotional Processing in Male Subjects with High Degrees of Alexithymia: An Event-Related fMRI Study},
  series = {Psychotherapy and Psychosomatics},
  volume    = {79},
  journal   = {Psychotherapy and Psychosomatics},
  number    = {6},
  publisher = {Karger},
  address   = {Basel},
  issn      = {0033-3190},
  doi       = {10.1159/000320121},
  pages     = {363 -- 370},
  year      = {2010},
  abstract  = {Background: One of the most prominent neurobiological models of alexithymia assumes an altered function of the anterior cingulate cortex (ACC) as the crucial neural correlate of alexithymia. So far functional imaging studies have yielded inconclusive results. Therefore, we tested this hypothesis in healthy alexithymics and nonalexithymics in an event-related fMRI study. Methods: Thirty high- and 30 low-alexithymic right-handed male subjects (selected by the 20-item Toronto Alexithymia Scale, TAS-20) were investigated with event-related fMRI using a picture viewing paradigm. The stimuli consisted of happy, fearful and neutral facial expressions (Ekman-Friesen) as well as positive, negative and neutral pictures from the International Affective Picture System. Results: Contrasting the high-alexithymic with the low-alexithymic group we observed increased activation of the supragenual ACC for different emotional valences as well as for different emotional stimuli. Moreover, there was a positive correlation of the ACC with the individual TAS-20 scores but no correlations with the individual Beck Depression Inventory scores. Additionally, there was no difference in activity of the amygdala. Conclusions: We demonstrated that the supragenual ACC is constantly activated more strongly in alexithymic subjects and that this activation is related to the symptoms of alexithymia and not to associated symptoms such as depression. Therefore, our findings support the hypothesis of an altered function of the ACC in alexithymia.},
  language  = {en}
}
@article{HeinzelSchaeferMuelleretal.2010,
  author    = {Heinzel, Alexander and Sch{\"a}fer, Ralf and M{\"u}ller, Hans-Wilhelm and Schieffer, Andre and Ingenhag, Ariane and Northoff, Georg and Franz, Matthias and Hautzel, Hubertus},
  title     = {Differential modulation of valence and arousal in high-alexithymic and low-alexithymic individuals},
  series = {Neuroreport},
  volume    = {21},
  journal   = {Neuroreport},
  number    = {15},
  publisher = {Lippincott Williams \& Wilkins},
  address   = {London},
  issn      = {1473-558X},
  doi       = {10.1097/WNR.0b013e32833f38e0},
  pages     = {998 -- 1002},
  year      = {2010},
  abstract  = {High-alexithymic individuals are characterized by an impaired ability to identify and communicate emotions whereas low-alexithymic individuals have a wide-ranging ability to deal with emotions. This study examined the hypothesis that valence and arousal modifications of emotional stimuli differentially modulate cortical regions in high-alexithymic and low-alexithymic individuals. To this end, 28 high-alexithymic and 25 low-alexithymic individuals were investigated with event-related fMRI using visual emotional stimuli. We found differential neural activations in the dorsal anterior cingulate, the insula and the amygdala. We suggest that these differences may account for the impaired ability of high-alexithymic individuals to appropriately handle emotional stimuli.},
  language  = {en}
}
@article{BeerStreunHombachetal.2010,
  author    = {Beer, S. and Streun, M. and Hombach, T. and Buehler, J. and Jahnke, S. and Khodaverdi, M. and Larue, H. and Minwuyelet, S. and Parl, C. and Roeb, G. and Schurr, U. and Ziemons, Karl},
  title     = {Design and initial performance of PlanTIS: a high-resolution positron emission tomograph for plants},
  series = {Physics in Medicine and Biology},
  volume    = {55},
  journal   = {Physics in Medicine and Biology},
  number    = {3},
  publisher = {IOP},
  address   = {Bristol},
  issn      = {1361-6560},
  doi       = {10.1088/0031-9155/55/3/006},
  pages     = {635 -- 646},
  year      = {2010},
  abstract  = {Positron emitters such as 11C, 13N and 18F and their labelled compounds are widely used in clinical diagnosis and animal studies, but can also be used to study metabolic and physiological functions in plants dynamically and in vivo. A very particular tracer molecule is 11CO2 since it can be applied to a leaf as a gas. We have developed a Plant Tomographic Imaging System (PlanTIS), a high-resolution PET scanner for plant studies. Detectors, front-end electronics and data acquisition architecture of the scanner are based on the ClearPET™ system. The detectors consist of LSO and LuYAP crystals in phoswich configuration which are coupled to position-sensitive photomultiplier tubes. Signals are continuously sampled by free running ADCs, and data are stored in a list mode format. The detectors are arranged in a horizontal plane to allow the plants to be measured in the natural upright position. Two groups of four detector modules stand face-to-face and rotate around the field-of-view. This special system geometry requires dedicated image reconstruction and normalization procedures. We present the initial performance of the detector system and first phantom and plant measurements.},
  language  = {en}
}
@article{HerzogPietrzykShahetal.2010,
  author    = {Herzog, Hans and Pietrzyk, Uwe and Shah, N. Jon and Ziemons, Karl},
  title     = {The current state, challenges and perspectives of MR-PET},
  series = {Neuroimage},
  volume    = {49},
  journal   = {Neuroimage},
  number    = {3},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1053-8119},
  doi       = {10.1016/j.neuroimage.2009.10.036},
  pages     = {2072 -- 2082},
  year      = {2010},
  abstract  = {Following the success of PET/CT during the last decade and the recent increasing proliferation of SPECT/CT, another hybrid imaging instrument has been gaining more and more interest: MR-PET. First combined, simultaneous PET and MR studies carried out in small animals demonstrated the feasibility of the new approach. Concurrently, some prototypes of an MR-PET scanner for simultaneous human brain studies have been built, their performance is being tested and preliminary applications have already been shown. Through this pioneering work, it has become clear that advances in the detector design are necessary for further optimization. Recently, the different issues related to the present state and future prospects of MR-PET were presented and discussed during an international 2-day workshop at the Forschungszentrum J{\"u}lich, Germany, held after, and in conjunction with, the 2008 IEEE Nuclear Science Symposium and Medical Imaging Conference in Dresden, Germany on October 27-28, 2008. The topics ranged from small animal MR-PET imaging to human MR-BrainPET imaging, new detector developments, challenges/opportunities for ultra-high field MR-PET imaging and considerations of possible future research and clinical applications. This report presents a critical summary of the contributions made to the workshop.},
  language  = {en}
}
@article{SchoeningKirchnerNgetal.2010,
  author    = {Sch{\"o}ning, Michael Josef and Kirchner, Patrick and Ng, Yue Ann and Spelthahn, Heiko and Schneider, Andreas and Henkel, Hartmut and Friedrich, Peter and Kolstad, Jens and Berger, J{\"o}rg and Keusgen, Michael},
  title     = {Gas sensor investigation based on a catalytically activated thin-film thermopile for H2O2 detection},
  series = {Physica Status Solidi (A). 207 (2010), H. 4},
  journal   = {Physica Status Solidi (A). 207 (2010), H. 4},
  isbn      = {1862-6300},
  pages     = {787 -- 792},
  year      = {2010},
  language  = {en}
}
@article{TurekHeidenGuoetal.2010,
  author    = {Turek, Monik and Heiden, Wolfgang and Guo, Sharon and Riesen, Alfred and Schubert, J{\"u}rgen and Zander, Willi and Kr{\"u}ger, Peter and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs},
  series = {Physica Status Solidi (A). 207 (2010), H. 4},
  journal   = {Physica Status Solidi (A). 207 (2010), H. 4},
  isbn      = {1862-6300},
  pages     = {817 -- 823},
  year      = {2010},
  language  = {en}
}
@article{ReisertHenkelSchneideretal.2010,
  author    = {Reisert, Steffen and Henkel, Hartmut and Schneider, Andreas and Sch{\"a}fer, Daniel and Friedrich, Peter and Berger, J{\"o}rg and Sch{\"o}ning, Michael Josef},
  title     = {Development of a handheld sensor system for the online measurement of hydrogen peroxide in aseptic filling systems},
  series = {Physica Status Solidi (A). 207 (2010), H. 4},
  journal   = {Physica Status Solidi (A). 207 (2010), H. 4},
  isbn      = {1862-6300},
  pages     = {913 -- 918},
  year      = {2010},
  language  = {en}
}
@article{MiyamotoSugawaraKanohetal.2010,
  author    = {Miyamoto, Ko-ichiro and Sugawara, Yuri and Kanoh, Shin´ichiro and Yoshinobu, Tatsuo and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Image correction method for the chemical imaging sensor},
  series = {Sensors and Actuators B: Chemical. 144 (2010), H. 2},
  journal   = {Sensors and Actuators B: Chemical. 144 (2010), H. 2},
  pages     = {344 -- 348},
  year      = {2010},
  language  = {en}
}
@article{BalakrishnanAndreiSelmerSelmeretal.2010,
  author    = {Balakrishnan, Karthikeyan and Andrei-Selmer, Luminita-Cornelia and Selmer, Thorsten and Bacher, Michael and Dodel, Richard},
  title     = {Comparison of Intravenous Immunoglobulins for Naturally Occurring Autoantibodies against Amyloid-β},
  series = {Journal of Alzheimer's Disease},
  volume    = {20},
  journal   = {Journal of Alzheimer's Disease},
  number    = {1},
  isbn      = {1387-2877},
  pages     = {135 -- 143},
  year      = {2010},
  language  = {en}
}
@article{JansenBehbahaniLaumenetal.2010,
  author    = {Jansen, Sebastian and Behbahani, Mehdi and Laumen, Marco and Kaufmann, Tim and Hormes, Marcus and Schmitz-Rode, Thomas and Behr, Marek and Steinseifer, Ulrich},
  title     = {3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques},
  year      = {2010},
  language  = {en}
}
@article{Hillgaertner2010,
  author    = {Hillg{\"a}rtner, Michael},
  title     = {Normative Regulations},
  series = {ECPE Cluster Seminar EMC in Hybrid and Electric Vehicles : 18 May 2010, Fraunhofer Institute Erlangen},
  journal   = {ECPE Cluster Seminar EMC in Hybrid and Electric Vehicles : 18 May 2010, Fraunhofer Institute Erlangen},
  publisher = {European Center for Power Electronics},
  address   = {N{\"u}rnberg},
  pages     = {1 CD-ROM},
  year      = {2010},
  language  = {en}
}
@article{HaselgruberMautnerThiele2010,
  author    = {Haselgruber, Nikolaus and Mautner, Karin and Thiele, Jan},
  title     = {Usage Space Analysis for Reliability Testing},
  series = {Quality and Reliability Engineering International},
  volume    = {26},
  journal   = {Quality and Reliability Engineering International},
  number    = {8},
  publisher = {Wiley},
  address   = {New York},
  issn      = {1099-1638},
  doi       = {10.1002/qre.1155},
  pages     = {877 -- 885},
  year      = {2010},
  abstract  = {During the development process of a complex technical product, one widely used and important technique is accelerated testing where the applied stress on a component is chosen to exceed the reference stress, i.e. the stress encountered in field operation, in order to reduce the time to failure. For that, the reference stress has to be known. Since a complex technical product may fail regarding numerous failure modes, stress in general is highly dimensional rather than scalar. In addition, customers use their products individually, i.e. field operation should be described by a distribution rather than by one scalar stress value. In this paper, a way to span the customer usage space is shown. It allows the identification of worst case reference stress profiles in significantly reduced dimensions with minimal loss of information. The application example shows that even for a complex product like a combustion engine, stress information can be compressed significantly. With low measurement effort it turned out that only three reference stress cycles were sufficient to cover a broad range of customer stress variety.},
  language  = {en}
}
@article{LettiniHavermannGuidettietal.2010,
  author    = {Lettini, Antonio and Havermann, Marc and Guidetti, Marco and Fornaciari, Andrea},
  title     = {Improved functionalities and energy saving potential on mobile machines combining electronics with flow sharing valve and variable displacement pump},
  series = {IFK 7, 7th International Fluid Power Conference, Efficiency through Fluid Power, 7. Internationales Fluidtechnisches Kolloquium, Workshop Proceedings, Vol. 3, Aachen, DE, 22.-24. Mar, 2010},
  journal   = {IFK 7, 7th International Fluid Power Conference, Efficiency through Fluid Power, 7. Internationales Fluidtechnisches Kolloquium, Workshop Proceedings, Vol. 3, Aachen, DE, 22.-24. Mar, 2010},
  publisher = {-},
  isbn      = {978-3-940565-92-1},
  pages     = {103 -- 114},
  year      = {2010},
  language  = {en}
}
@article{ChristenBarteltKowalski2010,
  author    = {Christen, Marc and Bartelt, Perry and Kowalski, Julia},
  title     = {Back calculation of the In den Arelen avalanche with RAMMS: Interpretation of model results},
  series = {Annals of Glaciology},
  volume    = {51},
  journal   = {Annals of Glaciology},
  number    = {54},
  publisher = {Cambridge University Press},
  address   = {Cambridge},
  isbn      = {1727-5644},
  doi       = {10.3189/172756410791386553},
  pages     = {161 -- 168},
  year      = {2010},
  abstract  = {Two- and three-dimensional avalanche dynamics models are being increasingly used in hazard-mitigation studies. These models can provide improved and more accurate results for hazard mapping than the simple one-dimensional models presently used in practice. However, two- and three-dimensional models generate an extensive amount of output data, making the interpretation of simulation results more difficult. To perform a simulation in three-dimensional terrain, numerical models require a digital elevation model, specification of avalanche release areas (spatial extent and volume), selection of solution methods, finding an adequate calculation resolution and, finally, the choice of friction parameters. In this paper, the importance and difficulty of correctly setting up and analysing the results of a numerical avalanche dynamics simulation is discussed. We apply the two-dimensional simulation program RAMMS to the 1968 extreme avalanche event In den Arelen. We show the effect of model input variations on simulation results and the dangers and complexities in their interpretation.},
  language  = {en}
}
@article{PieperKlein2010,
  author    = {Pieper, Martin and Klein, Peter},
  title     = {Numerical solution of the heat equation with non-linear, time derivative-dependent source term},
  series = {International Journal for Numerical Methods in Engineering},
  volume    = {84},
  journal   = {International Journal for Numerical Methods in Engineering},
  number    = {10},
  publisher = {Wiley},
  address   = {Chichester},
  issn      = {0029-5981},
  doi       = {10.1002/nme.2937},
  pages     = {1205 -- 1221},
  year      = {2010},
  abstract  = {The mathematical modeling of heat conduction with adsorption effects in coated metal structures yields the heat equation with piecewise smooth coefficients and a new kind of source term. This term is special, because it is non-linear and furthermore depends on a time derivative. In our approach we reformulated this as a new problem for the usual heat equation, without source term but with a new non-linear coefficient. We gave an existence and uniqueness proof for the weak solution of the reformulated problem. To obtain a numerical solution, we developed a semi-implicit and a fully implicit finite volume method. We compared these two methods theoretically as well as numerically. Finally, as practical application, we simulated the heat conduction in coated aluminum fibers with adsorption in the zeolite coating. Copyright © 2010 John Wiley \& Sons, Ltd.},
  language  = {en}
}
@article{BerretzSkorupaSanderetal.2010,
  author    = {Berretz, F. and Skorupa, S. and Sander, Volker and Belloum, A.},
  title     = {Towards an actor-driven workflow management system for grids},
  series = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE},
  journal   = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE},
  publisher = {IEEE},
  address   = {Piscataway, NJ},
  isbn      = {978-1-4244-6619-1},
  pages     = {611 -- 616},
  year      = {2010},
  language  = {en}
}
@article{WagnerWernerMiyamotoetal.2010,
  author    = {Wagner, Torsten and Werner, Frederik and Miyamoto, Ko-ichiro and Ackermann, Hans-Josef and Yoshinobu, Tatsuo and Sch{\"o}ning, Michael Josef},
  title     = {FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces},
  series = {Physica Status Solidi (A). 207 (2010), H. 4},
  journal   = {Physica Status Solidi (A). 207 (2010), H. 4},
  isbn      = {1862-6300},
  pages     = {844 -- 849},
  year      = {2010},
  language  = {en}
}
@article{BlomeChiconeHehletal.2010,
  author    = {Blome, Hans-Joachim and Chicone, Carmen and Hehl, Friedrich W. and Mashhoon, Bahram},
  title     = {Nonlocal modification of Newtonian gravity},
  series = {Physical Review D},
  volume    = {81},
  journal   = {Physical Review D},
  number    = {6},
  isbn      = {0556-2821},
  pages     = {065020},
  year      = {2010},
  language  = {en}
}
@article{FredebeulKreinKnoben2010,
  author    = {Fredebeul-Krein, Markus and Knoben, Werner},
  title     = {Long term risk sharing contracts as an approach to establish public-private partnerships for investment into next generation access networks},
  series = {Telecommunications Policy},
  volume    = {34},
  journal   = {Telecommunications Policy},
  number    = {9},
  isbn      = {0308-5961},
  pages     = {528 -- 539},
  year      = {2010},
  language  = {en}
}
@article{NamAroraBehbahanietal.2010,
  author    = {Nam, J. and Arora, D. and Behbahani, Mehdi and Probst, M. and Benkowski, R. and Behr, M. and Pasquali, M.},
  title     = {New computational method in hemolysis analysis for artificial heart pump},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniProbstMaietal.2010,
  author    = {Behbahani, Mehdi and Probst, M. and Mai, A. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.},
  title     = {Numerical Prediction of Blood Damage in Biomedical Devices},
  year      = {2010},
  language  = {en}
}
@article{ProbstBehbahaniBorrmannetal.2010,
  author    = {Probst, M. and Behbahani, Mehdi and Borrmann, E. and Elgeti, S. and Nicolai, M. and Behr, M.},
  title     = {Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniMaiBergmannetal.2010,
  author    = {Behbahani, Mehdi and Mai, A. and Bergmann, B. and Waluga, C. and Behr, M. and Tran, L. and Vonderstein, K. and Mottaghy, K.},
  title     = {Modeling and Numerical Simulation of Blood Damage},
  year      = {2010},
  language  = {en}
}
@article{BehbahaniMaiWalugaetal.2010,
  author    = {Behbahani, Mehdi and Mai, A. and Waluga, C. and Bergmann, B. and Tran, L. and Vonderstein, K. and Behr, M. and Mottaghy, K.},
  title     = {Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions},
  series = {Acta Physiologica},
  volume    = {198},
  journal   = {Acta Physiologica},
  number    = {Supplement 677},
  isbn      = {1748-1716},
  pages     = {185},
  year      = {2010},
  language  = {en}
}
@article{KotliarNagelVilseretal.2010,
  author    = {Kotliar, Konstantin and Nagel, Edgar and Vilser, Walthard and Seidova, Seid-Fatima and Lanzl, Ines},
  title     = {Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension},
  series = {Investigative Ophthalmology \& Visual Science, IOVS},
  volume    = {51},
  journal   = {Investigative Ophthalmology \& Visual Science, IOVS},
  number    = {4},
  publisher = {ARVO},
  address   = {Rockville, Md.},
  issn      = {0146-0404},
  doi       = {10.1167/iovs.09-3649},
  pages     = {2165 -- 2172},
  year      = {2010},
  abstract  = {Purpose: Image analysis by the retinal vessel analyzer (RVA) observes retinal vessels in their dynamic state online noninvasively along a chosen vessel segment. It has been found that high-frequency diameter changes in the retinal artery blood column along the vessel increase significantly in anamnestically healthy volunteers with increasing age and in patients with glaucoma during vascular dilation. This study was undertaken to investigate whether longitudinal sections of the retinal artery blood column are altered in systemic hypertension. Methods: Retinal arteries of 15 untreated patients with essential arterial hypertension (age, 50.9 ± 11.9 years) and of 15 age-matched anamnestically healthy volunteers were examined by RVA. After baseline assessment, a monochromatic luminance flicker (530-600 nm; 12.5 Hz; 20 s) was applied to evoke retinal vasodilation. Differences in amplitude and frequency of spatial artery blood column diameter change along segments (longitudinal arterial profiles) of 1 mm in length were measured and analyzed using Fourier transformation. Results: In the control group, average reduced power spectra (ARPS) of longitudinal arterial profiles did not differ when arteries changed from constriction to dilation. In the systemic hypertension group, ARPS during constriction, baseline, and restoration were identical and differed from ARPS during dilation (P < 0.05). Longitudinal arterial profiles in both groups showed significant dissimilitude at baseline and restoration (P < 0.05). Conclusions: The retinal artery blood column demonstrates microstructural alterations in systemic hypertension and is less irregular along the vessel axis during vessel dilation. These microstructural changes may be an indication of alterations in vessel wall rigidity, vascular endothelial function, and smooth muscle cells in this disease, leading to impaired perfusion and regulation.},
  language  = {en}
}
@article{PresslerEsefeldScherretal.2010,
  author    = {Pressler, Axel and Esefeld, Katrin and Scherr, Johannes and Ali, Mohammad and Hanssen, Henner and Kotliar, Konstantin and Lanzl, Ines and Halle, Martin and Kaemmerer, Harald and Schmidt-Trucks{\"a}ss, Arno and Hager, Alfred},
  title     = {Structural alterations of retinal arterioles in adults late after repair of aortic isthmic coarctation},
  series = {The American Journal of Cardiology},
  volume    = {105},
  journal   = {The American Journal of Cardiology},
  number    = {5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0002-9149},
  doi       = {10.1016/j.amjcard.2009.10.070},
  pages     = {740 -- 744},
  year      = {2010},
  abstract  = {Patients after coarctation repair still have an increased risk of cardiovascular or cerebrovascular events. This has been explained by the persisting hypertension and alterations in the peripheral vessels. However, involvement of the central vessels such as the retinal arteries is virtually unknown. A total of 34 patients after coarctation repair (22 men and 12 women; 23 to 58 years old, age range 0 to 32 years at surgical repair) and 34 nonhypertensive controls underwent structural and functional retinal vessel analysis. Using structural analysis, the vessel diameters were measured. Using functional analysis, the endothelium-dependent vessel dilation in response to flicker light stimulation was assessed. In the patients after coarctation repair, the retinal arteriolar diameter was significantly reduced compared to that of the controls (median 182 μm, first to third quartile 171 to 197; vs 197 μm, first to third quartile 193 to 206; p <0.001). These findings were independent of the peripheral blood pressure and age at intervention. No differences were found for venules. The functional analysis findings were not different between the patients and controls (maximum dilation 3.5\%, first to third quartile 2.1\% to 4.5\% vs 3.6\%, first to third quartile 2.2\% to 4.3\%; p = 0.81), indicating preserved autoregulative mechanisms. In conclusion, the retinal artery diameter is reduced in patients after coarctation repair, independent of their current blood pressure level and age at intervention. As a structural marker of chronic vessel damage associated with past, current, or future hypertension, retinal arteriolar narrowing has been linked to stroke incidence. These results indicate an involvement of cerebral microcirculation in aortic coarctation, despite timely repair, and might contribute to explain the increased rate of cerebrovascular events in such patients.},
  language  = {en}
}
@article{GarhoferBekBoehmetal.2010,
  author    = {Garhofer, Gerhard and Bek, Toke and Boehm, Andreas G. and Gherghel, Doina and Grundwald, Juan and Jeppesen, Peter and Kergoat, H{\´e}l{\`e}ne and Kotliar, Konstantin and Lanzl, Ines and Lovasik, John V. and Nagel, Edgar and Vilser, Walthard and Orgul, Selim and Schmetterer, Leopold},
  title     = {Use of the retinal vessel analyzer in ocular blood flow research},
  series = {Acta Ophthalmol},
  volume    = {88},
  journal   = {Acta Ophthalmol},
  number    = {7},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1755-3768},
  doi       = {10.1111/j.1755-3768.2009.01587.x},
  pages     = {717 -- 722},
  year      = {2010},
  abstract  = {The present article describes a standard instrument for the continuous online determination of retinal vessel diameters, the commercially available retinal vessel analyzer. This report is intended to provide informed guidelines for measuring ocular blood flow with this system. The report describes the principles underlying the method and the instruments currently available, and discusses clinical protocol and the specific parameters measured by the system. Unresolved questions and the possible limitations of the technique are also discussed.},
  language  = {en}
}
@article{HirschfeldLustfeldReisseletal.2010,
  author    = {Hirschfeld, J. A. and Lustfeld, H. and Reißel, Martin and Steffen, B.},
  title     = {A novel scheme for precise diagnostics and effective stabilization of currents in a fuel cell stack},
  series = {International Journal of Energy Research. 34 (2010), H. 3},
  journal   = {International Journal of Energy Research. 34 (2010), H. 3},
  isbn      = {0363-907X},
  pages     = {293 -- 301},
  year      = {2010},
  language  = {en}
}
@article{HirschfeldLustfeldReisseletal.2010,
  author    = {Hirschfeld, J. A. and Lustfeld, H. and Reißel, Martin and Steffen, B.},
  title     = {Tomographic diagnostics of current distributions in a fuel cell stack},
  series = {International Journal of Energy Research},
  volume    = {34},
  journal   = {International Journal of Energy Research},
  number    = {3},
  isbn      = {0363-907X},
  pages     = {284 -- 292},
  year      = {2010},
  language  = {en}
}
@article{ReisgenSchleserMokrovetal.2010,
  author    = {Reisgen, Uwe and Schleser, Markus and Mokrov, Oleg and Ahmed, Essam},
  title     = {Uni- and bi-axial deformation behavior of laser welded advanced high strength steel sheets},
  series = {Journal of materials processing technology},
  volume    = {210},
  journal   = {Journal of materials processing technology},
  number    = {15},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0924-0136},
  doi       = {http10.1016/j.jmatprotec.2010.08.003},
  pages     = {2188 -- 2196},
  year      = {2010},
  abstract  = {Bead-on-plate butt joints of 2.5 mm hot rolled DP600/DP600 and 1.2 mm cold rolled TRIP700/TRIP700 steel sheets were performed using 6 kW CO2 laser beam welding. The welding speed ranged from 1.5 to 3.0 and from 2.1 to 3.9 m/min in DP/DP and TRIP/TRIP steel weldments respectively. A top surface helium gas was used as a shielding gas at a flow rate of 20 l/min. Metallographic examinations and transverse tensile testing (DIN EN 895: 1995) were carried out to characterize the weldments. The formability of base metals and weldments were investigated by standard Erichsen test (DIN EN ISO 20482). It was found that the uniaxial plastic behavior of both DP600 and TRIP700 base metals was in agreement with Swift and modified Mecking-Kocks models respectively. In a perpendicular tensile test to the weld line, all specimens were fractured at the base metal however the strengths were somewhat higher than those of base metal. There was a significant reduction in formability caused by welding of both DP/DP and TRIP/TRIP steel weldments and the formability has been improved with the increase of the welding speed.},
  language  = {en}
}
@article{MukherjeePrahlBlecketal.2010,
  author    = {Mukherjee, Krishnendu and Prahl, Ulrich and Bleck, Wolfgang and Reisgen, Uwe and Schleser, Markus and Abdurakhmanov, Aydemir},
  title     = {Characterization and modelling techniques for gas metal arc welding of DP 600 sheet steels},
  series = {Materialwissenschaft und Werkstofftechnik},
  volume    = {41},
  journal   = {Materialwissenschaft und Werkstofftechnik},
  number    = {11},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-4052},
  doi       = {10.1002/mawe.201000692},
  pages     = {972 -- 983},
  year      = {2010},
  abstract  = {The objectives of the present work are to characterize the Gas Metal Arc Welding process of DP 600 sheet steel and to summarize the modelling techniques. The time-temperature evolution during the welding cycle was measured experimentally and modelled with the softwaretool SimWeld. To model the phase transformations during the welding cycle dilatometer tests were done to quantify the parameters for phase field modelling by MICRESS®. The important input parameters are interface mobility, nucleation density, etc. A contribution was made to include austenite to bainite transformation in MICRESS®. This is useful to predict the microstructure in the fast cooling segments. The phase transformation model is capable to predict the microstructure along the heating and cooling cycles of welding. Tensile tests have shown the evidence of failure at the heat affected zone, which has the ferrite-tempered martensite microstructure.},
  language  = {en}
}
@article{AhmedReisgenSchleseretal.2010,
  author    = {Ahmed, Essam and Reisgen, Uwe and Schleser, Markus and Mokrov, Oleg},
  title     = {On formability of tailor laser welded blanks of DP/TRIP steel sheets},
  series = {Science and technology of welding and joining},
  volume    = {15},
  journal   = {Science and technology of welding and joining},
  number    = {5},
  publisher = {Maney},
  address   = {Leeds},
  issn      = {1743-2936},
  doi       = {10.1179/136217110X12731414739754},
  pages     = {337 -- 342},
  year      = {2010},
  abstract  = {This paper aims to evaluate the formability of tailor welded blanks of dual phase (DP600)/transformation induced plasticity (TRIP700) steel sheets. In this work, bead on plate butt joints of 2·5 mm DP600 and 1·2 mm TRIP700 steel sheets were performed using CO2 laser beam welding. Microhardness measurements and transverse tensile testing were carried out to characterise the welds. The formability of base metals and welds were investigated by standard Erichsen test. In a perpendicular tensile test to the weld line, all specimens were fractured at the TRIP base metal, and the strengths were somewhat higher than those of base metal. There was a significant reduction in formability caused by welding of the DP600/TRIP700 steel sheets, and the formability increased with increasing welding speed.},
  language  = {en}
}
@article{ReisgenSchleserMokrovetal.2010,
  author    = {Reisgen, Uwe and Schleser, Markus and Mokrov, Oleg and Ahmed, Essam},
  title     = {Shielding gas influences on laser weldability of tailored blanks of advanced automotive steels},
  series = {Applied surface science},
  volume    = {257},
  journal   = {Applied surface science},
  number    = {5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0169-4332 (E-Journal); 0169-4332 (Print)},
  doi       = {10.1016/j.apsusc.2010.08.042},
  pages     = {1401 -- 1406},
  year      = {2010},
  abstract  = {The effects of shielding gas types and flow rates on CO2 laser weldability of DP600/TRIP700 steel sheets were studied in this work. The evaluated shielding gases were helium (He), argon (Ar) and different mixtures of He and Ar. Weld penetration, tensile strength and formability (Erichsen test) of laser welds were found to be strongly dependent upon the shielding gas types. The ability of shielding gas in removing plasma plume and thus increasing weld penetration is believed to be closely related to ionization potential and atomic weight which determine the period of plasma formation and disappearance. It was found that the higher helium shielding gas flow rate, the deeper weld penetration and the lower weld width.},
  language  = {en}
}
@article{VogtMottaghyWolfetal.2010,
  author    = {Vogt, C. and Mottaghy, Darius and Wolf, A. and Rath, V. and Pechnig, R. and Clauser, C.},
  title     = {Reducing temperature uncertainties by stochastic geothermal reservoir modelling},
  series = {Geophysical Journal International},
  volume    = {181},
  journal   = {Geophysical Journal International},
  number    = {1},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1365-246X},
  doi       = {10.1111/j.1365-246X.2009.04498.x},
  pages     = {321 -- 333},
  year      = {2010},
  abstract  = {Quantifying and minimizing uncertainty is vital for simulating technically and economically successful geothermal reservoirs. To this end, we apply a stochastic modelling sequence, a Monte Carlo study, based on (i) creating an ensemble of possible realizations of a reservoir model, (ii) forward simulation of fluid flow and heat transport, and (iii) constraining post-processing using observed state variables. To generate the ensemble, we use the stochastic algorithm of Sequential Gaussian Simulation and test its potential fitting rock properties, such as thermal conductivity and permeability, of a synthetic reference model and—performing a corresponding forward simulation—state variables such as temperature. The ensemble yields probability distributions of rock properties and state variables at any location inside the reservoir. In addition, we perform a constraining post-processing in order to minimize the uncertainty of the obtained distributions by conditioning the ensemble to observed state variables, in this case temperature. This constraining post-processing works particularly well on systems dominated by fluid flow. The stochastic modelling sequence is applied to a large, steady-state 3-D heat flow model of a reservoir in The Hague, Netherlands. The spatial thermal conductivity distribution is simulated stochastically based on available logging data. Errors of bottom-hole temperatures provide thresholds for the constraining technique performed afterwards. This reduce the temperature uncertainty for the proposed target location significantly from 25 to 12 K (full distribution width) in a depth of 2300 m. Assuming a Gaussian shape of the temperature distribution, the standard deviation is 1.8 K. To allow a more comprehensive approach to quantify uncertainty, we also implement the stochastic simulation of boundary conditions and demonstrate this for the basal specific heat flow in the reservoir of The Hague. As expected, this results in a larger distribution width and hence, a larger, but more realistic uncertainty estimate. However, applying the constraining post-processing the uncertainty is again reduced to the level of the post-processing without stochastic boundary simulation. Thus, constraining post-processing is a suitable tool for reducing uncertainty estimates by observed state variables.},
  language  = {en}
}
@article{FellinKingKirschetal.2010,
  author    = {Fellin, Wolfgang and King, Julian and Kirsch, Ansgar and Oberguggenberger, Michael},
  title     = {Uncertainty modelling and sensitivity analysis of tunnel face stability},
  series = {Structural safety},
  volume    = {32},
  journal   = {Structural safety},
  number    = {6},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0167-4730},
  doi       = {10.1016/j.strusafe.2010.06.001},
  pages     = {402 -- 410},
  year      = {2010},
  abstract  = {This paper proposes an approach to the choice and evaluation of engineering models with the aid of a typical application in geotechnics. An important issue in the construction of shallow tunnels, especially in weak ground conditions, is the tunnel face stability. Various theoretical and numerical models for predicting the necessary support pressure have been put forth in the literature. In this paper, we combine laboratory experiments performed at the University of Innsbruck with current methods of uncertainty and sensitivity analysis for assessing adequacy, predictive power and robustness of the models. The major issues are the handling of the twofold uncertainty of test results and of model predictions as well as the decision about what are the influential input parameters.},
  language  = {en}
}
@article{Kirsch2010,
  author    = {Kirsch, Ansgar},
  title     = {Experimental investigation of the face stability of shallow tunnels in sand},
  series = {Acta Geotechnica},
  volume    = {5},
  journal   = {Acta Geotechnica},
  number    = {1},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1861-1125},
  doi       = {10.1007/s11440-010-0110-7},
  pages     = {43 -- 62},
  year      = {2010},
  abstract  = {Various models have been proposed for the prediction of the necessary support pressure at the face of a shallow tunnel. To assess their quality, the collapse of a tunnel face was modelled with small-scale model tests at single gravity. The development of the failure mechanism and the support force at the face in dry sand were investigated. The observed displacement patterns show a negligible influence of overburden on the extent and evolution of the failure zone. The latter is significantly influenced, though, by the initial density of the sand: in dense sand a chimney-wedge-type collapse mechanism developed, which propagated towards the soil surface. Initially, loose sand did not show any discrete collapse mechanism. The necessary support force was neither influenced by the overburden nor the initial density. A comparison with quantitative predictions by several theoretical models showed that the measured necessary support pressure is overestimated by most of the models. Those by Vermeer/Ruse and L{\´e}ca/Dormieux showed the best agreement to the measurements.},
  language  = {en}
}
@article{AlexopoulosHoffschmidt2010,
  author    = {Alexopoulos, Spiros and Hoffschmidt, Bernhard},
  title     = {Solar tower power plant in Germany and future perspectives of the development of the technology in Greece and Cyprus},
  series = {Renewable Energy . 35 (2010), H. 7},
  journal   = {Renewable Energy . 35 (2010), H. 7},
  isbn      = {0960-1481},
  pages     = {1352 -- 1356},
  year      = {2010},
  language  = {en}
}
@article{FerreinNiemuellerSteinbauer2010,
  author    = {Ferrein, Alexander and Niem{\"u}ller, Tim and Steinbauer, Gerald},
  title     = {Team Zadeat 2010 : application for participation},
  pages     = {5 Seiten},
  year      = {2010},
  language  = {en}
}
@article{KurzLinderTrzewiketal.2010,
  author    = {Kurz, R. and Linder, Peter and Trzewik, J{\"u}rgen and R{\"u}ffer, M. and Artmann, Gerhard and Digel, Ilya and Rothermel, A. and Robitzki, A. and Temiz Artmann, Ayseg{\"u}l},
  title     = {Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes},
  series = {Medical and Biological Engineering and Computing},
  volume    = {48},
  journal   = {Medical and Biological Engineering and Computing},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1741-0444},
  doi       = {10.1007/s11517-009-0552-y},
  pages     = {59 -- 65},
  year      = {2010},
  abstract  = {The CellDrum technology (The term 'CellDrum technology' includes a couple of slightly different technological setups for measuring lateral mechanical tension in various types of cell monolayers or 3D-tissue constructs) was designed to quantify the contraction rate and mechanical tension of self-exciting cardiac myocytes. Cells were grown either within flexible, circular collagen gels or as monolayer on top of respective 1-mum thin silicone membranes. Membrane and cells were bulged outwards by air pressure. This biaxial strain distribution is rather similar the beating, blood-filled heart. The setup allowed presetting the mechanical residual stress level externally by adjusting the centre deflection, thus, mimicking hypertension in vitro. Tension was measured as oscillating differential pressure change between chamber and environment. A 0.5-mm thick collagen-cardiac myocyte tissue construct induced after 2 days of culturing (initial cell density 2 x 10(4) cells/ml), a mechanical tension of 1.62 +/- 0.17 microN/mm(2). Mechanical load is an important growth regulator in the developing heart, and the orientation and alignment of cardiomyocytes is stress sensitive. Therefore, it was necessary to develop the CellDrum technology with its biaxial stress-strain distribution and defined mechanical boundary conditions. Cells were exposed to strain in two directions, radially and circumferentially, which is similar to biaxial loading in real heart tissues. Thus, from a biomechanical point of view, the system is preferable to previous setups based on uniaxial stretching.},
  language  = {en}
}
@article{TippkoetterRoikaewUlberetal.2010,
  author    = {Tippk{\"o}tter, Nils and Roikaew, Wipa and Ulber, Roland and Hoffmann, Alexander and Denzler, Hans-J{\"o}rg and Buchholz, Heinrich},
  title     = {Paracoccus denitrificans for the effluent recycling during continuous denitrification of liquid food},
  series = {Biotechnology Progress},
  volume    = {26},
  journal   = {Biotechnology Progress},
  number    = {3},
  publisher = {Wiley},
  address   = {Hoboken, NJ},
  issn      = {8756-7938},
  doi       = {10.1002/btpr.384},
  pages     = {756 -- 762},
  year      = {2010},
  abstract  = {Nitrate is an undesirable component of several foods. A typical case of contamination with high nitrate contents is whey concentrate, containing nitrate in concentrations up to 25 l. The microbiological removal of nitrate by Paracoccus denitrificans under formation of harmless nitrogen in combination with a cell retention reactor is described here. Focus lies on the resource-conserving design of a microbal denitrification process. Two methods are compared. The application of polyvinyl alcohol-immobilized cells, which can be applied several times in whey feed, is compared with the implementation of a two step denitrification system. First, the whey concentrate's nitrate is removed by ion exchange and subsequently the eluent regenerated by microorganisms under their retention by crossflow filtration. Nitrite and nitrate concentrations were determined by reflectometric color measurement with a commercially available Reflectoquant® device. Correction factors for these media had to be determined. During the pilot development, bioreactors from 4 to 250 mg·L-1 and crossflow units with membrane areas from 0.02 to 0.80 m2 were examined. Based on the results of the pilot plants, a scaling for the exemplary process of denitrifying 1,000 tons per day is discussed.},
  language  = {en}
}
@article{PhamVuTranetal.2010,
  author    = {Pham, Phu Tinh and Vu, Khoi Duc and Tran, Thanh Ngoc and Staat, Manfred},
  title     = {A primal-dual algorithm for shakedown analysis of elastic-plastic bounded linearly kinematic hardening bodies},
  pages     = {1 -- 7},
  year      = {2010},
  language  = {en}
}
@article{NguyenRaatschenStaat2010,
  author    = {Nguyen, N.-H. and Raatschen, Hans-J{\"u}rgen and Staat, Manfred},
  title     = {A hyperelastic model of biological tissue materials in tubular organs},
  pages     = {1 -- 12},
  year      = {2010},
  language  = {en}
}
@article{BeckerFrauenrathHezeletal.2010,
  author    = {Becker, Meike and Frauenrath, Tobias and Hezel, Fabian and Krombach, Gabriele A. and Kremer, Ute and Koppers, Benedikt and Butenweg, Christoph and Goemmel, Andreas and Utting, Jane F. and Schulz-Menger, Jeanette and Niendorf, Thoralf},
  title     = {Comparison of left ventricular function assessment using phonocardiogram- and electrocardiogram-triggered 2D SSFP CINE MR imaging at 1.5 T and 3.0 T},
  series = {European Radiology},
  volume    = {20},
  journal   = {European Radiology},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1432-1084 (Onlineausgabe)},
  doi       = {10.1007/s00330-009-1676-z},
  pages     = {1344 -- 1355},
  year      = {2010},
  abstract  = {Objective: As high-field cardiac MRI (CMR) becomes more widespread the propensity of ECG to interference from electromagnetic fields (EMF) and to magneto-hydrodynamic (MHD) effects increases and with it the motivation for a CMR triggering alternative. This study explores the suitability of acoustic cardiac triggering (ACT) for left ventricular (LV) function assessment in healthy subjects (n=14). Methods: Quantitative analysis of 2D CINE steady-state free precession (SSFP) images was conducted to compare ACT's performance with vector ECG (VCG). Endocardial border sharpness (EBS) was examined paralleled by quantitative LV function assessment. Results: Unlike VCG, ACT provided signal traces free of interference from EMF or MHD effects. In the case of correct Rwave recognition, VCG-triggered 2D CINE SSFP was immune to cardiac motion effects—even at 3.0 T. However, VCG-triggered 2D SSFP CINE imaging was prone to cardiac motion and EBS degradation if R-wave misregistration occurred. ACT-triggered acquisitions yielded LV parameters (end-diastolic volume (EDV), endsystolic volume (ESV), stroke volume (SV), ejection fraction (EF) and left ventricular mass (LVM)) comparable with those derived fromVCG-triggered acquisitions (1.5 T: ESVVCG=(56± 17) ml, EDVVCG=(151±32)ml, LVMVCG=(97±27) g, SVVCG=(94± 19)ml, EFVCG=(63±5)\% cf. ESVACT= (56±18) ml, EDVACT=(147±36) ml, LVMACT=(102±29) g, SVACT=(91± 22) ml, EFACT=(62±6)\%; 3.0 T: ESVVCG=(55±21) ml, EDVVCG=(151±32) ml, LVMVCG=(101±27) g, SVVCG=(96±15) ml, EFVCG=(65±7)\% cf. ESVACT=(54±20) ml, EDVACT=(146±35) ml, LVMACT= (101±30) g, SVACT=(92±17) ml, EFACT=(64±6)\%). Conclusions: ACT's intrinsic insensitivity to interference from electromagnetic fields renders},
  language  = {en}
}
@article{SiqueiraMakiPaulovichetal.2010,
  author    = {Siqueira, Jose R. and Maki, Rafael M. and Paulovich, Fernando V. and Werner, Frederik and Poghossian, Arshak and Oliveira, Maria C. F. de and Zucolotto, Valtencir and Oliveira, Osvaldo N. Jr. and Sch{\"o}ning, Michael Josef},
  title     = {Use of Information Visualization Methods Eliminating Cross Talk in Multiple Sensing Units Investigated for a Light-Addressable Potentiometric Sensor},
  series = {Analytical Chemistry (2010)},
  journal   = {Analytical Chemistry (2010)},
  isbn      = {0003-2700},
  pages     = {61 -- 65},
  year      = {2010},
  language  = {en}
}
@article{ArampatzisPeperBierbaumetal.2010,
  author    = {Arampatzis, Adamantios and Peper, Andreas and Bierbaum, Stefanie and Albracht, Kirsten},
  title     = {Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain},
  series = {Journal of Biomechanics},
  volume    = {43},
  journal   = {Journal of Biomechanics},
  number    = {16},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2010.08.014},
  pages     = {3073 -- 3079},
  year      = {2010},
  abstract  = {The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47\%), and the other leg at high tendon strain magnitude (4.72±1.08\%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon-aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon-aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.},
  language  = {en}
}
@article{AggeloussisGiannakouAlbrachtetal.2010,
  author    = {Aggeloussis, Nickos and Giannakou, Erasmia and Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Reproducibility of fascicle length and pennation angle of gastrocnemius medialis in human gait in vivo},
  series = {Gait and Posture},
  volume    = {31},
  journal   = {Gait and Posture},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0966-6362},
  doi       = {10.1016/j.gaitpost.2009.08.249},
  pages     = {73 -- 77},
  year      = {2010},
  abstract  = {The purpose of the current study was to examine the reproducibility of fascicle length and pennation angle of gastrocnemius medialis while human walking. To the best of our knowledge, this is the first study of the reproducibility of fascicle length and pennation angle of gastrocnemius medialis in vivo during human gait. Twelve males performed 10 gait trials on a treadmill, in 2 separate days. B-mode ultrasonography, with the ultrasound probe firmly adjusted in the transverse and frontal planes using a special cast, was used to measure the fascicle length and the pennation angle of the gastrocnemius medialis (GM). A Vicon 624 system with three cameras operating at 120 Hz was also used to record the ankle and knee joint angles. The results showed that measurements of fascicle length and pennation angle showed high reproducibility during the gait cycle, both within the same day and between different days. Moreover, the root mean square differences between the repeated waveforms of both variables were very small, compared with their ranges (fascicle length: RMS = ∼3 mm, range: 38-63 mm; pennation angle: RMS = ∼1.5°, range: 22-32°). However, their reproducibility was lower compared to the joint angles. It was found that representative data have to be derived by a wide number of gait trials (fascicle length ∼six trials, pennation angle more than 10 trials), to assure the reliability of the fascicle length and pennation angle in human gait.},
  language  = {en}
}
@article{RossPlummerRodeetal.2010,
  author    = {Ross, Jillian and Plummer, Simon M. and Rode, Anja and Scheer, Nico and Bower, Conrad C. and Vogel, Ortwin and Henderson, Colin J. and Wolf, C. Roland and Elcombe, Clifford R.},
  title     = {Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo},
  series = {Toxicological Sciences},
  volume    = {116},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1096-0929},
  doi       = {10.1093/toxsci/kfq118},
  pages     = {452 -- 466},
  year      = {2010},
  abstract  = {Mouse nongenotoxic hepatocarcinogens phenobarbital (PB) and chlordane induce hepatomegaly characterized by hypertrophy and hyperplasia. Increased cell proliferation is implicated in the mechanism of tumor induction. The relevance of these tumors to human health is unclear. The xenoreceptors, constitutive androstane receptors (CARs), and pregnane X receptor (PXR) play key roles in these processes. Novel "humanized" and knockout models for both receptors were developed to investigate potential species differences in hepatomegaly. The effects of PB (80 mg/kg/4 days) and chlordane (10 mg/kg/4 days) were investigated in double humanized PXR and CAR (huPXR/huCAR), double knockout PXR and CAR (PXRKO/CARKO), and wild-type (WT) C57BL/6J mice. In WT mice, both compounds caused increased liver weight, hepatocellular hypertrophy, and cell proliferation. Both compounds caused alterations to a number of cell cycle genes consistent with induction of cell proliferation in WT mice. However, these gene expression changes did not occur in PXRKO/CARKO or huPXR/huCAR mice. Liver hypertrophy without hyperplasia was demonstrated in the huPXR/huCAR animals in response to both compounds. Induction of the CAR and PXR target genes, Cyp2b10 and Cyp3a11, was observed in both WT and huPXR/huCAR mouse lines following treatment with PB or chlordane. In the PXRKO/CARKO mice, neither liver growth nor induction of Cyp2b10 and Cyp3a11 was seen following PB or chlordane treatment, indicating that these effects are CAR/PXR dependent. These data suggest that the human receptors are able to support the chemically induced hypertrophic responses but not the hyperplastic (cell proliferation) responses. At this time, we cannot be certain that hCAR and hPXR when expressed in the mouse can function exactly as the genes do when they are expressed in human cells. However, all parameters investigated to date suggest that much of their functionality is maintained.},
  language  = {en}
}
@article{ScheerRossKapelyukhetal.2010,
  author    = {Scheer, Nico and Ross, Jillian and Kapelyukh, Yury and Rode, Anja and Wolf, C. Roland},
  title     = {In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice},
  series = {Drug Metabolism and Disposition},
  volume    = {38},
  journal   = {Drug Metabolism and Disposition},
  number    = {7},
  publisher = {ASPET},
  address   = {Bethesda},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.109.031872},
  pages     = {1046 -- 1053},
  year      = {2010},
  abstract  = {Dexamethasone (DEX) is a potent and widely used anti-inflammatory and immunosuppressant glucocorticoid. It can bind and activate the pregnane X receptor (PXR), which plays a critical role as xenobiotic sensor in mammals to induce the expression of many enzymes, including cytochromes P450 in the CYP3A family. This induction results in its own metabolism. We have used a series of transgenic mouse lines, including a novel, improved humanized PXR line, to compare the induction profile of PXR-regulated drug-metabolizing enzymes after DEX administration, as well as looking at hepatic responses to rifampicin (RIF). The new humanized PXR model has uncovered further intriguing differences between the human and mouse receptors in that RIF only induced Cyp2b10 in the new humanized model. DEX was found to be a much more potent inducer of Cyp3a proteins in wild-type mice than in mice humanized for PXR. To assess whether PXR is involved in the detoxification of DEX in the liver, we analyzed the consequences of high doses of the glucocorticoid on hepatotoxicity on different PXR genetic backgrounds. We also studied these effects in an additional mouse model in which functional mouse Cyp3a genes have been deleted. These strains exhibited different sensitivities to DEX, indicating a protective role of the PXR and CYP3A proteins against the hepatotoxicity of this compound.},
  language  = {en}
}