@article{MolinnusHardtKaeveretal.2018,
  author    = {Molinnus, Denise and Hardt, G. and K{\"a}ver, L. and Willenberg, H.S. and Kr{\"o}ger, J.-C. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Chip-based biosensor for the detection of low adrenaline concentrations to support adrenal venous sampling},
  series = {Sensor and Actuators B: Chemical},
  volume    = {272},
  journal   = {Sensor and Actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2018.05.136},
  pages     = {21 -- 27},
  year      = {2018},
  abstract  = {A chip-based amperometric biosensor referring on using the bioelectrocatalytical amplification principle for the detection of low adrenaline concentrations is presented. The adrenaline biosensor has been prepared by modification of a platinum thin-film electrode with an enzyme membrane containing the pyrroloquinoline quinone-dependent glucose dehydrogenase and glutaraldehyde. Measuring conditions such as temperature, pH value, and glucose concentration have been optimized to achieve a high sensitivity and a low detection limit of about 1 nM adrenaline measured in phosphate buffer at neutral pH value. The response of the biosensor to different catecholamines has also been proven. Long-term stability of the adrenaline biosensor has been studied over 10 days. In addition, the biosensor has been successfully applied for adrenaline detection in human blood plasma for future biomedical applications. Furthermore, preliminary experiments have been carried to detect the adrenaline-concentration difference measured in peripheral blood and adrenal venous blood, representing the adrenal vein sampling procedure of a physician.},
  language  = {en}
}
@article{KochPoghossianSchoeningetal.2018,
  author    = {Koch, Claudia and Poghossian, Arshak and Sch{\"o}ning, Michael Josef and Wege, Christian},
  title     = {Penicillin Detection by Tobacco Mosaic Virus-Assisted Colorimetric Biosensors},
  series = {Nanotheranostics},
  volume    = {2},
  journal   = {Nanotheranostics},
  number    = {2},
  publisher = {Ivyspring},
  address   = {Sydney},
  issn      = {2206-7418},
  doi       = {10.7150/ntno.22114},
  pages     = {184 -- 196},
  year      = {2018},
  abstract  = {The presentation of enzymes on viral scaffolds has beneficial effects such as an increased enzyme loading and a prolonged reusability in comparison to conventional immobilization platforms. Here, we used modified tobacco mosaic virus (TMV) nanorods as enzyme carriers in penicillin G detection for the first time. Penicillinase enzymes were conjugated with streptavidin and coupled to TMV rods by use of a bifunctional biotin-linker. Penicillinase-decorated TMV particles were characterized extensively in halochromic dye-based biosensing. Acidometric analyte detection was performed with bromcresol purple as pH indicator and spectrophotometry. The TMV-assisted sensors exhibited increased enzyme loading and strongly improved reusability, and higher analysis rates compared to layouts without viral adapters. They extended the half-life of the sensors from 4 - 6 days to 5 weeks and thus allowed an at least 8-fold longer use of the sensors. Using a commercial budget-priced penicillinase preparation, a detection limit of 100 µM penicillin was obtained. Initial experiments also indicate that the system may be transferred to label-free detection layouts.},
  language  = {en}
}
@article{Golland2018,
  author    = {Golland, Alexander},
  title     = {Der r{\"a}umliche Anwendungsbereich der DS-GVO},
  series = {DuD Datenschutz und Datensicherheit},
  volume    = {42},
  journal   = {DuD Datenschutz und Datensicherheit},
  number    = {6},
  publisher = {Springer},
  address   = {Heidelberg},
  isbn      = {1862-2607},
  pages     = {351 -- 357},
  year      = {2018},
  abstract  = {Die Datenschutz-Grundverordnung (DS-GVO) regelt in ihrem Art. 3 das r{\"a}umlich anwendbare Datenschutzrecht und zielt dabei gerade auch auf Angebote nichteurop{\"a}ischer Diensteanbieter ab. Die bisherige Diskussion konzentriert sich bislang in erster Linie darauf, das eingef{\"u}hrte Marktortprinzip zu thematisieren; das weitgehend unangetastete Niederlassungsprinzip und vor allem die Probleme, die sich durch dessen unver{\"a}nderte Beibehaltung ergeben, werden dagegen nicht er{\"o}rtert. Der folgende Beitrag versucht sich an einer systematischen Analyse eines teils kontrovers, teils kaum diskutierten Themas.},
  language  = {de}
}
@article{KeutmannStaatLaack2018,
  author    = {Keutmann, Sabine and Staat, Manfred and Laack, Walter van},
  title     = {Untersuchung der thermischen Auswirkung von therapeutischem Ultraschall},
  volume    = {7},
  number    = {10},
  publisher = {Deutscher {\"A}rzte-Verl.},
  address   = {K{\"o}ln},
  issn      = {2193-5793},
  pages     = {518 -- 522},
  year      = {2018},
  abstract  = {Zusammenfassung: In der Orthop{\"a}die z{\"a}hlt der therapeutische Ultraschall als Mittel zur Pr{\"a}vention und Therapiebegleitung. Er hat mechanische, thermische und physiko-chemische Auswirkungen auf den menschlichen K{\"o}rper. Um mehr Erkenntnisse {\"u}ber die thermischen Auswirkungen zu erlangen, wurden Versuche an einem Hydrogel-Phantom und an Probanden durchgef{\"u}hrt. Dabei entstand eine signifikante Erw{\"a}rmung des Gewebes, welche beim Probandenversuch an der Oberfl{\"a}che und beim Hydrogelversuch in der Tiefe gemessen wurde. Summary: In orthopaedics, therapeutic ultrasound is a tool of prevention and therapy support. It has mechanical, thermal and physico-chemical effects on the human body. Tests with a hydrogel phantom and with human probands have been performed in order to obtain more knowledge about their thermal effects. Both tests measured temperature increases in cell tissue, on the surface with the human proband test and in depth with the hydrogel phantom test.},
  language  = {de}
}
@article{FingerBraunBil2018,
  author    = {Finger, Felix and Braun, Carsten and Bil, Cees},
  title     = {Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs},
  series = {CEAS Aeronautical Journal},
  volume    = {10},
  journal   = {CEAS Aeronautical Journal},
  number    = {3},
  publisher = {Springer},
  issn      = {1869-5582 print},
  doi       = {10.1007/s13272-018-0352-x},
  pages     = {843},
  year      = {2018},
  abstract  = {One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost-benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters.},
  language  = {en}
}
@article{HueningHeuermannWacheetal.2018,
  author    = {H{\"u}ning, Felix and Heuermann, Holger and Wache, Franz-Josef and Jajo, Rami Audisho},
  title     = {A new wireless sensor interface using dual-mode radio},
  series = {Journal of Sensors and Sensor Systems : JSSS},
  volume    = {Volume 7},
  journal   = {Journal of Sensors and Sensor Systems : JSSS},
  number    = {2},
  publisher = {Copernicus Publ.},
  address   = {G{\"o}ttingen},
  doi       = {10.5194/jsss-7-507-2018},
  pages     = {507 -- 515},
  year      = {2018},
  abstract  = {The integration of sensors is one of the major tasks in embedded, control and "internet of things" (IoT) applications. For the integration mainly digital interfaces are used, starting from rather simple pulse-width modulation (PWM) interface to more complex interfaces like CAN (Controller Area Network). Even though these interfaces are tethered by definition, a wireless realization is highly welcome in many applications to reduce cable and connector cost, increase the flexibility and realize new emerging applications like wireless control systems. Currently used wireless solutions like Bluetooth, WirelessHART or IO-Link Wireless use dedicated communication standards and corresponding higher protocol layers to realize the wireless communication. Due to the complexity of the communication and the protocol handling, additional latency and jitter are introduced to the data communication that can meet the requirements for many applications. Even though tunnelling of other bus data like CAN data is generally also possible the latency and jitter prevent the tunnelling from being transparent for the bus system. Therefore a new basic technology based on dual-mode radio is used to realize a wireless communication on the physical layer only, enabling a reliable and real-time data transfer. As this system operates on the physical layer it is independent of any higher layers of the OSI (open systems interconnection) model. Hence it can be used for several different communication systems to replace the tethered physical layer. A prototype is developed and tested for real-time wireless PWM, SENT (single-edge nibble transmission) and CAN data transfer with very low latency and jitter.},
  language  = {en}
}
@article{BergSchleserDelidovichetal.2018,
  author    = {Berg, Alexander-Karl and Schleser, Markus and Delidovich, Artem and Houben, Alexander},
  title     = {Ultraschallunterst{\"u}tzter Schmelzklebstoffauftrag},
  series = {adh{\"a}sion KLEBEN \& DICHTEN},
  volume    = {Volume 62},
  journal   = {adh{\"a}sion KLEBEN \& DICHTEN},
  number    = {Issue 12},
  publisher = {Springer},
  doi       = {10.1007/s35145-018-0089-z},
  pages     = {32 -- 37},
  year      = {2018},
  language  = {de}
}
@article{HarrisKleefeld2018,
  author    = {Harris, Isaac and Kleefeld, Andreas},
  title     = {The inverse scattering problem for a conductive boundary condition and transmission eigenvalues},
  series = {Applicable Analysis},
  volume    = {99},
  journal   = {Applicable Analysis},
  number    = {3},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1563-504X},
  doi       = {10.1080/00036811.2018.1504028},
  pages     = {508 -- 529},
  year      = {2018},
  abstract  = {In this paper, we consider the inverse scattering problem associated with an inhomogeneous media with a conductive boundary. In particular, we are interested in two problems that arise from this inverse problem: the inverse conductivity problem and the corresponding interior transmission eigenvalue problem. The inverse conductivity problem is to recover the conductive boundary parameter from the measured scattering data. We prove that the measured scatted data uniquely determine the conductivity parameter as well as describe a direct algorithm to recover the conductivity. The interior transmission eigenvalue problem is an eigenvalue problem associated with the inverse scattering of such materials. We investigate the convergence of the eigenvalues as the conductivity parameter tends to zero as well as prove existence and discreteness for the case of an absorbing media. Lastly, several numerical and analytical results support the theory and we show that the inside-outside duality method can be used to reconstruct the interior conductive eigenvalues.},
  language  = {en}
}
@article{PuppeGiulianoFrantzetal.2018,
  author    = {Puppe, Michael and Giuliano, Stefano and Frantz, Cathy and Uhlig, Ralf and Schumacher, Ralph and Ibraheem, Wagdi and Schmalz, Stefan and Waldmann, Barbara and Guder, Christoph and Peter, Dennis and Schwager, Christian and Teixeira Boura, Cristiano Jos{\´e} and Alexopoulos, Spiros and Spiegel, Michael and Wortmann, J{\"u}rgen and Hinrichs, Matthias and Engelhard, Manfred and Aust, Michael},
  title     = {Techno-economic optimization of molten salt solar tower plants},
  series = {AIP Conference Proceedings art.no. 040033},
  volume    = {2033},
  journal   = {AIP Conference Proceedings art.no. 040033},
  number    = {Issue 1},
  publisher = {AIP Publishing},
  address   = {Melville, NY},
  doi       = {10.1063/1.5067069},
  year      = {2018},
  abstract  = {In this paper the results of a techno-economic analysis of improved and optimized molten salt solar tower plants (MSSTP plants) are presented. The potential improvements that were analyzed include different receiver designs, different designs of the HTF-system and plant control, increased molten salt temperatures (up to 640°C) and multi-tower systems. Detailed technological and economic models of the solar field, solar receiver and high temperature fluid system (HTF-system) were developed and used to find potential improvements compared to a reference plant based on Solar Two technology and up-to-date cost estimations. The annual yield model calculates the annual outputs and the LCOE of all variants. An improved external tubular receiver and improved HTF-system achieves a significant decrease of LCOE compared to the reference. This is caused by lower receiver cost as well as improvements of the HTF-system and plant operation strategy, significantly reducing the plant own consumption. A novel star receiver shows potential for further cost decrease. The cavity receiver concepts result in higher LCOE due to their high investment cost, despite achieving higher efficiencies. Increased molten salt temperatures seem possible with an adapted, closed loop HTF-system and achieve comparable results to the original improved system (with 565°C) under the given boundary conditions. In this analysis all multi tower systems show lower economic viability compared to single tower systems, caused by high additional cost for piping connections and higher cost of the receivers. REFERENCES},
  language  = {en}
}
@article{Fissabre2018,
  author    = {Fissabre, Anke},
  title     = {Die Relevanz der historischen Bauforschung f{\"u}r neue Impulse in Stadtplanung und Architektur. Das Beispiel der Chiesa della SS. Maria Incoronata und des Servitenklosters in Sabbioneta.},
  series = {archimaera},
  journal   = {archimaera},
  number    = {Nr. 7, Juli 2018},
  publisher = {Archimaera},
  address   = {Aachen},
  issn      = {1865-7001},
  url       = {http://nbn-resolving.de/urn:nbn:de:0009-21-47067},
  pages     = {99 -- 105},
  year      = {2018},
  abstract  = {Durch die Bauforschung im Rahmen des mehrj{\"a}hrigen Projektes "Die Hochkorridore von Sabbioneta" konnten der Verlauf und viele Anschl{\"u}sse der hochliegenden G{\"a}nge an bestehende Bauten weitgehend gekl{\"a}rt werden. Im Bereich der Chiesa della SS. Maria Incoronata und des angrenzenden Servitenklosters f{\"u}hrten die Bauuntersuchungen zu v{\"o}llig neuen Erkenntnissen {\"u}ber den ehemaligen Verlauf des Hochkorridors und damit zu einer Neuinterpretation des baulichen Ensembles sowie seiner Bedeutung f{\"u}r die Idealstadt. Aus dieser historischen Umdeutung entstanden Ideen f{\"u}r die Umnutzung des ehemaligen Servitenklosters und seiner angrenzenden Freifl{\"a}chen, die im Rahmen von studentischen Entw{\"u}rfen am Lehrstuhl f{\"u}r Baugeschichte und Denkmalpflege in Kooperation mit dem Lehrstuhl f{\"u}r Landschaftsarchitektur der RWTH Aachen weiterentwickelt wurden. Somit stellten sich Befunde einer historisch orientierten Bauforschung mit {\"u}bergeordneter Fragestellung als neue Impulsgeber f{\"u}r Stadtplanung, Architektur und Denkmalpflege heraus.},
  language  = {de}
}
@article{BaringhausGaigallThiele2018,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel and Thiele, Jan Philipp},
  title     = {Statistical inference for L²-distances to uniformity},
  series = {Computational Statistics},
  volume    = {2018},
  journal   = {Computational Statistics},
  number    = {33},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1613-9658},
  doi       = {10.1007/s00180-018-0820-0},
  pages     = {1863 -- 1896},
  year      = {2018},
  abstract  = {The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study.},
  language  = {en}
}
@article{BronderJessingPoghossianetal.2018,
  author    = {Bronder, Thomas and Jessing, Max P. and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef},
  title     = {Detection of PCR-Amplified Tuberculosis DNA Fragments with Polyelectrolyte-Modified Field-Effect Sensors},
  series = {Analytical Chemistry},
  volume    = {90},
  journal   = {Analytical Chemistry},
  number    = {12},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {0003-2700},
  doi       = {10.1021/acs.analchem.8b01807},
  pages     = {7747 -- 7753},
  year      = {2018},
  abstract  = {Field-effect-based electrolyte-insulator-semiconductor (EIS) sensors were modified with a bilayer of positively charged weak polyelectrolyte (poly(allylamine hydrochloride) (PAH)) and probe single-stranded DNA (ssDNA) and are used for the detection of complementary single-stranded target DNA (cDNA) in different test solutions. The sensing mechanism is based on the detection of the intrinsic molecular charge of target cDNA molecules after the hybridization event between cDNA and immobilized probe ssDNA. The test solutions contain synthetic cDNA oligonucleotides (with a sequence of tuberculosis mycobacteria genome) or PCR-amplified DNA (which origins from a template DNA strand that has been extracted from Mycobacterium avium paratuberculosis-spiked human sputum samples), respectively. Sensor responses up to 41 mV have been measured for the test solutions with DNA, while only small signals of ∼5 mV were detected for solutions without DNA. The lower detection limit of the EIS sensors was ∼0.3 nM, and the sensitivity was ∼7.2 mV/decade. Fluorescence experiments using SybrGreen I fluorescence dye support the electrochemical results.},
  language  = {en}
}
@article{DitzhausGaigall2018,
  author    = {Ditzhaus, Marc and Gaigall, Daniel},
  title     = {A consistent goodness-of-fit test for huge dimensional and functional data},
  series = {Journal of Nonparametric Statistics},
  volume    = {30},
  journal   = {Journal of Nonparametric Statistics},
  number    = {4},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1029-0311},
  doi       = {10.1080/10485252.2018.1486402},
  pages     = {834 -- 859},
  year      = {2018},
  abstract  = {A nonparametric goodness-of-fit test for random variables with values in a separable Hilbert space is investigated. To verify the null hypothesis that the data come from a specific distribution, an integral type test based on a Cram{\´e}r-von-Mises statistic is suggested. The convergence in distribution of the test statistic under the null hypothesis is proved and the test's consistency is concluded. Moreover, properties under local alternatives are discussed. Applications are given for data of huge but finite dimension and for functional data in infinite dimensional spaces. A general approach enables the treatment of incomplete data. In simulation studies the test competes with alternative proposals.},
  language  = {en}
}
@article{JildehOberlaenderKirchneretal.2018,
  author    = {Jildeh, Zaid B. and Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, Michael and Wagner, Patrick H. and Sch{\"o}ning, Michael Josef},
  title     = {Experimental and Numerical Analyzes of a Sensor Based on Interdigitated Electrodes for Studying Microbiological Alterations},
  series = {physica status solidi (a): applications and materials science},
  volume    = {215},
  journal   = {physica status solidi (a): applications and materials science},
  number    = {15},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201700920},
  pages     = {Artikel 1700920},
  year      = {2018},
  abstract  = {In this work, a cell-based biosensor to evaluate the sterilization efficacy of hydrogen peroxide vapor sterilization processes is characterized. The transducer of the biosensor is based on interdigitated gold electrodes fabricated on an inert glass substrate. Impedance spectroscopy is applied to evaluate the sensor behavior and the alteration of test microorganisms due to the sterilization process. These alterations are related to changes in relative permittivity and electrical conductivity of the bacterial spores. Sensor measurements are conducted with and without bacterial spores (Bacillus atrophaeus), as well as after an industrial sterilization protocol. Equivalent two-dimensional numerical models based on finite element method of the periodic finger structures of the interdigitated gold electrodes are designed and validated using COMSOL® Multiphysics software by the application of known dielectric properties. The validated models are used to compute the electrical properties at different sensor states (blank, loaded with spores, and after sterilization). As a final result, we will derive and tabulate the frequency-dependent electrical parameters of the spore layer using a novel model that combines experimental data with numerical optimization techniques.},
  language  = {en}
}
@article{Kurz2018,
  author    = {Kurz, Melanie},
  title     = {Was heißt: Verantwortung im Design? Historische Positionen},
  series = {Boxhorn: das Magazin aus dem Fachbereich Gestaltung der FH Aachen},
  journal   = {Boxhorn: das Magazin aus dem Fachbereich Gestaltung der FH Aachen},
  number    = {34},
  address   = {Aachen},
  pages     = {26 -- 33},
  year      = {2018},
  language  = {de}
}
@article{BaringhausGaigall2018,
  author    = {Baringhaus, Ludwig and Gaigall, Daniel},
  title     = {Efficiency comparison of the Wilcoxon tests in paired and independent survey samples},
  series = {Metrika},
  volume    = {2018},
  journal   = {Metrika},
  number    = {81},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1435-926X},
  doi       = {10.1007/s00184-018-0661-4},
  pages     = {891 -- 930},
  year      = {2018},
  abstract  = {The efficiency concepts of Bahadur and Pitman are used to compare the Wilcoxon tests in paired and independent survey samples. A comparison through the length of corresponding confidence intervals is also done. Simple conditions characterizing the dominance of a procedure are derived. Statistical tests for checking these conditions are suggested and discussed.},
  language  = {de}
}
@article{BerneckerKlierSternetal.2018,
  author    = {Bernecker, Andreas and Klier, Julia and Stern, Sebastian and Thiel, Lea},
  title     = {Sustaining high performance beyond public-sector pilot projects.},
  number    = {September 2018},
  organization    = {McKinsey\&Company},
  year      = {2018},
  language  = {en}
}
@article{HirschKleebergSchmitz2018,
  author    = {Hirsch, Marko and Kleeberg, Jochen and Schmitz, Philipp},
  title     = {Dynamische Asset-Allocation- Strategien im Niedrigzinsumfeld},
  series = {Absolut|report : neue Perspektiven f{\"u}r institutionelle Investoren},
  journal   = {Absolut|report : neue Perspektiven f{\"u}r institutionelle Investoren},
  number    = {6},
  publisher = {Absolut Research},
  address   = {Hamburg},
  pages     = {52},
  year      = {2018},
  language  = {de}
}
@article{Golland2018,
  author    = {Golland, Alexander},
  title     = {Umsetzung der Datenschutz-Grundverordnung - Neue Herausforderungen f{\"u}r Unternehmen},
  series = {NWB Rechnungswesen - BBK},
  journal   = {NWB Rechnungswesen - BBK},
  number    = {1},
  isbn      = {0340-9848},
  pages     = {35 -- 39},
  year      = {2018},
  abstract  = {Nach einem intensiven politischen Diskurs wurde im vergangenen Jahr die Datenschutz-Grundverordnung (DSGVO) verabschiedet. Die DSGVO ersetzt zum 25.5.2018 die bislang geltende, aus dem Jahre 1995 stammende Datenschutz-Richtlinie 95/46/EG. Die Novellierung des Datenschutzrechts bringt zahlreiche neue Anforderungen mit sich. Unternehmen sind daher gezwungen, sich auf die {\"A}nderungen einzustellen, ihre datenschutzrelevanten Prozesse im Hinblick auf die neuen Anforderungen zu {\"u}berpr{\"u}fen und bis zum Mai 2018 an der DSGVO auszurichten. Der Beitrag gibt einen kurzen {\"U}berblick {\"u}ber die zentralen Aspekte der Datenschutzreform und die damit einhergehenden Herausforderungen f{\"u}r Unternehmen.},
  language  = {de}
}
@article{RabehiGarlanAchtsnichtetal.2018,
  author    = {Rabehi, Amine and Garlan, Benjamin and Achtsnicht, Stefan and Krause, Hans-Joachim and Offenh{\"a}usser, Andreas and Ngo, Kieu and Neveu, Sophie and Graff-Dubois, Stephanie and Kokabi, Hamid},
  title     = {Magnetic detection structure for Lab-on-Chip applications based on the frequency mixing technique},
  series = {Sensors},
  volume    = {18},
  journal   = {Sensors},
  number    = {6},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s18061747},
  pages     = {14 Seiten},
  year      = {2018},
  abstract  = {A magnetic frequency mixing technique with a set of miniaturized planar coils was investigated for use with a completely integrated Lab-on-Chip (LoC) pathogen sensing system. The system allows the detection and quantification of superparamagnetic beads. Additionally, in terms of magnetic nanoparticle characterization ability, the system can be used for immunoassays using the beads as markers. Analytical calculations and simulations for both excitation and pick-up coils are presented; the goal was to investigate the miniaturization of simple and cost-effective planar spiral coils. Following these calculations, a Printed Circuit Board (PCB) prototype was designed, manufactured, and tested for limit of detection, linear response, and validation of theoretical concepts. Using the magnetic frequency mixing technique, a limit of detection of 15 µg/mL of 20 nm core-sized nanoparticles was achieved without any shielding.},
  language  = {en}
}
@article{BhattaraiStaat2018,
  author    = {Bhattarai, Aroj and Staat, Manfred},
  title     = {Computational comparison of different textile implants to correct apical prolapse in females},
  series = {Current Directions in Biomedical Engineering},
  volume    = {4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  doi       = {10.1515/cdbme-2018-0159},
  pages     = {661 -- 664},
  year      = {2018},
  abstract  = {Prosthetic textile implants of different shapes, sizes and polymers are used to correct the apical prolapse after hysterectomy (removal of the uterus). The selection of the implant before or during minimally invasive surgery depends on the patient's anatomical defect, intended function after reconstruction and most importantly the surgeon's preference. Weakness or damage of the supporting tissues during childbirth, menopause or previous pelvic surgeries may put females in higher risk of prolapse. Numerical simulations of reconstructed pelvic floor with weakened tissues and organ supported by textile product models: DynaMesh®-PRS soft, DynaMesh®-PRP soft and DynaMesh®-CESA from FEG Textiletechnik mbH, Germany are compared.},
  language  = {en}
}
@article{RuppSchulzeKuperjans2018,
  author    = {Rupp, Matthias and Schulze, Sven and Kuperjans, Isabel},
  title     = {Comparative life cycle analysis of conventional and hybrid heavy-duty trucks},
  series = {World electric vehicle journal},
  volume    = {9},
  journal   = {World electric vehicle journal},
  number    = {2},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2032-6653},
  doi       = {10.3390/wevj9020033},
  pages     = {Article No. 33},
  year      = {2018},
  abstract  = {Heavy-duty trucks are one of the main contributors to greenhouse gas emissions in German traffic. Drivetrain electrification is an option to reduce tailpipe emissions by increasing energy conversion efficiency. To evaluate the vehicle's environmental impacts, it is necessary to consider the entire life cycle. In addition to the daily use, it is also necessary to include the impact of production and disposal. This study presents the comparative life cycle analysis of a parallel hybrid and a conventional heavy-duty truck in long-haul operation. Assuming a uniform vehicle glider, only the differing parts of both drivetrains are taken into account to calculate the environmental burdens of the production. The use phase is modeled by a backward simulation in MATLAB/Simulink considering a characteristic driving cycle. A break-even analysis is conducted to show at what mileage the larger CO2eq emissions due to the production of the electric drivetrain are compensated. The effect of parameter variation on the break-even mileage is investigated by a sensitivity analysis. The results of this analysis show the difference in CO2eq/t km is negative, indicating that the hybrid vehicle releases 4.34 g CO2eq/t km over a lifetime fewer emissions compared to the diesel truck. The break-even analysis also emphasizes the advantages of the electrified drivetrain, compensating the larger emissions generated during production after already a distance of 15,800 km (approx. 1.5 months of operation time). The intersection coordinates, distance, and CO2eq, strongly depend on fuel, emissions for battery production and the driving profile, which lead to nearly all parameter variations showing an increase in break-even distance.},
  language  = {en}
}
@article{HorbachStaat2018,
  author    = {Horbach, Andreas and Staat, Manfred},
  title     = {Optical strain measurement for the modeling of surgical meshes and their porosity},
  series = {Current Directions in Biomedical Engineering},
  volume    = {Band 4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2364-5504},
  doi       = {10.1515/cdbme-2018-0045},
  pages     = {181 -- 184},
  year      = {2018},
  abstract  = {The porosity of surgical meshes makes them flexible for large elastic deformation and establishes the healing conditions of good tissue in growth. The biomechanic modeling of orthotropic and compressible materials requires new materials models and simulstaneoaus fit of deformation in the load direction as well as trannsversely to to load. This nonlinear modeling can be achieved by an optical deformation measurement. At the same time the full field deformation measurement allows the dermination of the change of porosity with deformation. Also the socalled effective porosity, which has been defined to asses the tisssue interatcion with the mesh implants, can be determined from the global deformation of the surgical meshes.},
  language  = {en}
}
@article{PoghossianJablonskiKochetal.2018,
  author    = {Poghossian, Arshak and Jablonski, Melanie and Koch, Claudia and Bronder, Thomas and Rolka, David and Wege, Christina and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect biosensor using virus particles as scaffolds for enzyme immobilization},
  series = {Biosensors and Bioelectronics},
  volume    = {110},
  journal   = {Biosensors and Bioelectronics},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0956-5663},
  doi       = {10.1016/j.bios.2018.03.036},
  pages     = {168 -- 174},
  year      = {2018},
  abstract  = {A field-effect biosensor employing tobacco mosaic virus (TMV) particles as scaffolds for enzyme immobilization is presented. Nanotubular TMV scaffolds allow a dense immobilization of precisely positioned enzymes with retained activity. To demonstrate feasibility of this new strategy, a penicillin sensor has been developed by coupling a penicillinase with virus particles as a model system. The developed field-effect penicillin biosensor consists of an Al-p-Si-SiO₂-Ta₂O₅-TMV structure and has been electrochemically characterized in buffer solutions containing different concentrations of penicillin G. In addition, the morphology of the biosensor surface with virus particles was characterized by scanning electron microscopy and atomic force microscopy methods. The sensors possessed a high penicillin sensitivity of ~ 92 mV/dec in a nearly-linear range from 0.1 mM to 10 mM, and a low detection limit of about 50 µM. The long-term stability of the penicillin biosensor was periodically tested over a time period of about one year without any significant loss of sensitivity. The biosensor has also been successfully applied for penicillin detection in bovine milk samples.},
  language  = {en}
}
@article{AboulnagaZouSelmeretal.2018,
  author    = {Aboulnaga, Elhussiny A. and Zou, Huibin and Selmer, Thorsten and Xian, Mo},
  title     = {Development of a plasmid-based, tunable, tolC-derived expression system for application in Cupriavidus necator H16},
  series = {Journal of Biotechnology},
  volume    = {274},
  journal   = {Journal of Biotechnology},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0168-1656},
  doi       = {10.1016/j.jbiotec.2018.03.007},
  pages     = {15 -- 27},
  year      = {2018},
  abstract  = {Cupriavidus necator H16 gains increasing attention in microbial research and biotechnological application due to its diverse metabolic features. Here we present a tightly controlled gene expression system for C. necator including the pBBR1-vector that contains hybrid promoters originating from C. necator native tolC-promoter in combination with a synthetic tetO-operator. The expression of the reporter gene from these plasmids relies on the addition of the exogenous inducer doxycycline (dc). The novel expression system offers a combination of advantageous features as; (i) high and dose-dependent recombinant protein production, (ii) tight control with a high dynamic range (On/Off ratio), which makes it applicable for harmful pathways or for toxic protein production, (iii) comparable cheap inducer (doxycycline, dc), (iv) effective at low inducer concentration, that makes it useful for large scale application, (v) rapid, diffusion controlled induction, and (vi) the inducer does not interfere within the cell metabolism. As applications of the expression system in C. necator H16, the growth ability on glycerol was enhanced by constitutively expressing the E. coli glpk gene-encoding for glycerol kinase. Likewise, we used the system to overcome the expression toxicity of mevalonate pathway in C. necator H16. With this system, the mevalonate-genes were successfully introduced in the host and the recombinant strains could produce about 200 mg/l mevalonate.},
  language  = {en}
}