@book{IomdinaBauerKotliar2015, author = {Iomdina, E. N. and Bauer, S. M. and Kotliar, Konstantin}, title = {БИОМЕХАНИКА ГЛАЗА: ТЕОРЕТИЧЕСКИЕ АСПЕКТЫ И КЛИНИЧЕСКИЕ ПРИЛОЖЕНИЯ}, publisher = {Real Time}, address = {Moscow}, isbn = {978-5-903025-57-2}, pages = {208 Seiten}, year = {2015}, language = {ru} } @article{BertzSchoeningMolinnusetal.2024, author = {Bertz, Morten and Sch{\"o}ning, Michael Josef and Molinnus, Denise and Homma, Takayuki}, title = {Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping}, series = {Physica status solidi (a) applications and materials science}, journal = {Physica status solidi (a) applications and materials science}, number = {Early View}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6319 (Online)}, doi = {10.1002/pssa.202300866}, pages = {8 Seiten}, year = {2024}, abstract = {To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30\% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem.}, language = {en} } @incollection{KraftKohlMeinecke2024, author = {Kraft, Bodo and Kohl, Philipp and Meinecke, Matthias}, title = {Analyse und Nachverfolgung von Projektzielen durch Einsatz von Natural Language Processing}, series = {KI in der Projektwirtschaft : was ver{\"a}ndert sich durch KI im Projektmanagement?}, booktitle = {KI in der Projektwirtschaft : was ver{\"a}ndert sich durch KI im Projektmanagement?}, editor = {Bernert, Christian and Scheurer, Steffen and Wehnes, Harald}, publisher = {UVK Verlag}, isbn = {978-3-3811-1132-9 (Online)}, doi = {10.24053/9783381111329}, pages = {157 -- 167}, year = {2024}, language = {de} } @article{SchoenrockMuckeltHastermannetal.2024, author = {Schoenrock, Britt and Muckelt, Paul E. and Hastermann, Maria and Albracht, Kirsten and MacGregor, Robert and Martin, David and Gunga, Hans-Christian and Salanova, Michele and Stokes, Maria J. and Warner, Martin B. and Blottner, Dieter}, title = {Muscle stiffness indicating mission crew health in space}, series = {Scientific Reports}, volume = {14}, journal = {Scientific Reports}, number = {Article number: 4196}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-024-54759-6}, pages = {13 Seiten}, year = {2024}, abstract = {Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes.}, language = {en} } @techreport{SiegertBongaertsWagneretal.2022, author = {Siegert, Petra and Bongaerts, Johannes and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Selmer, Thorsten}, title = {Abschlussbericht zum Projekt zur {\"U}berwachung biotechnologischer Prozesse mittels Diacetyl-/Acetoin-Biosensor und Evaluierung von Acetoin-Reduktasen zur Verwendung in Biotransformationen}, address = {Aachen}, organization = {FH Aachen}, pages = {16 Seiten}, year = {2022}, language = {de} } @unpublished{RingersBialonskiSolovevetal.2021, author = {Ringers, Christa and Bialonski, Stephan and Solovev, Anton and Hansen, Jan N. and Ege, Mert and Friedrich, Benjamin M. and Jurisch-Yaksi, Nathalie}, title = {Preprint: Local synchronization of cilia and tissue-scale cilia alignment are sufficient for global metachronal waves}, series = {bioRxiv}, journal = {bioRxiv}, doi = {10.1101/2021.11.23.469646}, pages = {19 Seiten}, year = {2021}, abstract = {Motile cilia are hair-like cell extensions present in multiple organs of the body. How cilia coordinate their regular beat in multiciliated epithelia to move fluids remains insufficiently understood, particularly due to lack of rigorous quantification. We combine here experiments, novel analysis tools, and theory to address this knowledge gap. We investigate collective dynamics of cilia in the zebrafish nose, due to its conserved properties with other ciliated tissues and its superior accessibility for non-invasive imaging. We revealed that cilia are synchronized only locally and that the size of local synchronization domains increases with the viscosity of the surrounding medium. Despite the fact that synchronization is local only, we observed global patterns of traveling metachronal waves across the multiciliated epithelium. Intriguingly, these global wave direction patterns are conserved across individual fish, but different for left and right nose, unveiling a chiral asymmetry of metachronal coordination. To understand the implications of synchronization for fluid pumping, we used a computational model of a regular array of cilia. We found that local metachronal synchronization prevents steric collisions and improves fluid pumping in dense cilia carpets, but hardly affects the direction of fluid flow. In conclusion, we show that local synchronization together with tissue-scale cilia alignment are sufficient to generate metachronal wave patterns in multiciliated epithelia, which enhance their physiological function of fluid pumping.}, language = {en} } @incollection{Bialonski2016, author = {Bialonski, Stephan}, title = {Are interaction clusters in epileptic networks predictive of seizures?}, series = {Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics}, booktitle = {Epilepsy: The Intersection of Neurosciences, Biology, Mathematics, Engineering, and Physics}, publisher = {CRC Press}, isbn = {978-143983886-0}, pages = {349 -- 355}, year = {2016}, language = {en} } @inproceedings{ArtmannStadlerEmbsetal.2010, author = {Artmann, Gerhard and Stadler, Andreas M. and Embs, Jan P. and Zaccai, Giuseppe and B{\"u}ldt, Georg and Digel, Ilya and Temiz Artmann, Ayseg{\"u}l}, title = {The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract]}, year = {2010}, abstract = {The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature}, subject = {H{\"a}moglobin}, language = {en} } @article{AkimbekovDigelAbdievaetal.2021, author = {Akimbekov, Nuraly S. and Digel, Ilya and Abdieva, Gulzhamal and Ualieva, Perizat and Tastambek, Kuanysh}, title = {Lignite biosolubilization and bioconversion by Bacillus sp.: the collation of analytical data}, series = {Biofuels}, volume = {12}, journal = {Biofuels}, number = {3}, publisher = {Taylor \& Francis}, address = {London}, issn = {1759-7277}, pages = {247 -- 258}, year = {2021}, abstract = {The vast metabolic potential of microbes in brown coal (lignite) processing and utilization can greatly contribute to innovative approaches to sustainable production of high-value products from coal. In this study, the multi-faceted and complex coal biosolubilization process by Bacillus sp. RKB 7 isolate from the Kazakhstan coal-mining soil is reported, and the derived products are characterized. Lignite solubilization tests performed for surface and suspension cultures testify to the formation of numerous soluble lignite-derived substances. Almost 24\% of crude lignite (5\% w/v) was solubilized within 14 days under slightly alkaline conditions (pH 8.2). FTIR analysis revealed various functional groups in the obtained biosolubilization products. Analyses of the lignite-derived humic products by UV-Vis and fluorescence spectrometry as well as elemental analysis yielded compatible results indicating the emerging products had a lower molecular weight and degree of aromaticity. Furthermore, XRD and SEM analyses were used to evaluate the biosolubilization processes from mineralogical and microscopic points of view. The findings not only contribute to a deeper understanding of microbe-mineral interactions in coal environments, but also contribute to knowledge of coal biosolubilization and bioconversion with regard to sustainable production of humic substances. The detailed and comprehensive analyses demonstrate the huge biotechnological potential of Bacillus sp. for agricultural productivity and environmental health.}, language = {en} } @article{DigelAkimbekovRogachevetal.2023, author = {Digel, Ilya and Akimbekov, Nuraly S. and Rogachev, Evgeniy and Pogorelova, Natalia}, title = {Bacterial cellulose produced by Medusomyces gisevii on glucose and sucrose: biosynthesis and structural properties}, series = {Cellulose}, journal = {Cellulose}, publisher = {Springer Science + Business Media}, address = {Dordrecht}, issn = {1572-882X (Online)}, doi = {10.1007/s10570-023-05592-z}, pages = {15 Seiten}, year = {2023}, abstract = {In this work, the effects of carbon sources and culture media on the production and structural properties of bacterial cellulose (BC) synthesized by Medusomyces gisevii have been studied. The culture medium was composed of different initial concentrations of glucose or sucrose dissolved in 0.4\% extract of plain green tea. Parameters of the culture media (titratable acidity, substrate conversion degree etc.) were monitored daily for 20 days of cultivation. The BC pellicles produced on different carbon sources were characterized in terms of biomass yield, crystallinity and morphology by field emission scanning electron microscopy (FE-SEM), atomic force microscopy and X-ray diffraction. Our results showed that Medusomyces gisevii had higher BC yields in media with sugar concentrations close to 10 g L-1 after a 18-20 days incubation period. Glucose in general lead to a higher BC yield (173 g L-1) compared to sucrose (163.5 g L-1). The BC crystallinity degree and surface roughness were higher in the samples synthetized from sucrose. Obtained FE-SEM micrographs show that the BC pellicles synthesized in the sucrose media contained densely packed tangles of cellulose fibrils whereas the BC produced in the glucose media displayed rather linear geometry of the BC fibrils without noticeable aggregates.}, language = {en} } @article{TuraliyevaYeshibaevDigeletal.2014, author = {Turaliyeva, M. and Yeshibaev, A. and Digel, Ilya and Elibayeva, G. and Sydykova, A. and Uspabayeva, A. and Dosybayeva, G. and Zhylysbayeva, A. and Lakhanova, K.}, title = {Molecular-genetic identification of emerged novel invasive pathogens of Asiatic Elm Ulmus pumila L}, series = {Life science journal}, volume = {11}, journal = {Life science journal}, number = {Spec. iss. 5s}, publisher = {Marsland Press}, address = {New York}, issn = {1097-8135}, doi = {10.7537/marslsj1105s14.33}, pages = {171 -- 175}, year = {2014}, abstract = {The dwarf elm Ulmus pumila L. (Ulmaceae) is one of indigenous species of flora in Kazakhstan and forms a basis of dendroflora in virtually all settlements of the region. In the past decade, multiple outbreaks of previously unknown diseases of the small-leaved elm have been registered. In our study, by the molecular-genetic analysis it was found that the pathogens responsible for the outbreaks are microfungi belonging to the genus Fusarium - F. solani and F. oxysporum. The nucleotide sequences (ITS regions) isolated from the diseased trees showed very high similarity with the GenBank control numbers EU625403.1 and FJ478128.1 (100.0 and 99.0 \% respectively). Oncoming research will focus on the search of natural microbial antagonists of the discovered phytopathogens.}, language = {en} } @article{BialonskiAllefeldWellmeretal.2008, author = {Bialonski, Stephan and Allefeld, C. and Wellmer, J. and Elger, C. and Lehnertz, K.}, title = {An approach to identify synchronization clusters within the epileptic network}, series = {Klinische Neurophysiologie}, volume = {39}, journal = {Klinische Neurophysiologie}, number = {1}, doi = {10.1055/s-2008-1072881}, pages = {A79}, year = {2008}, language = {en} } @article{ZhubanovaDigelNojimaetal.2007, author = {Zhubanova, Azhar A. and Digel, Ilya and Nojima, H. and Artmann, Gerhard}, title = {The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology}, year = {2007}, abstract = {The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells.}, subject = {Clusterion}, language = {en} } @article{BogoyavlenskiyDigelBerezin1997, author = {Bogoyavlenskiy, A. P. and Digel, Ilya and Berezin, V. E.}, title = {Assessment of dot-blot ELISA sensitivity on membrane sorbent using various peroxidase substrates}, year = {1997}, abstract = {The sensitivity of the peroxidase reaction in dot-blot ELISA significantly depends on the substrate. The highest sensitivity is observed using benzidine and diamine- phenol combinations as the substrates due to the reaction of the coupled oxidation (NADI)}, subject = {Enzyme-linked immunosorbent assay}, language = {en} } @incollection{BialonskiLehnertz2013, author = {Bialonski, Stephan and Lehnertz, Klaus}, title = {From time series to complex networks: an overview}, series = {Recent Advances in Predicting and Preventing Epileptic Seizures: Proceedings of the 5th International Workshop on Seizure Prediction}, booktitle = {Recent Advances in Predicting and Preventing Epileptic Seizures: Proceedings of the 5th International Workshop on Seizure Prediction}, isbn = {978-981-4525-36-7}, doi = {10.1142/9789814525350_0010}, pages = {132 -- 147}, year = {2013}, abstract = {The network approach towards the analysis of the dynamics of complex systems has been successfully applied in a multitude of studies in the neurosciences and has yielded fascinating insights. With this approach, a complex system is considered to be composed of different constituents which interact with each other. Interaction structures can be compactly represented in interaction networks. In this contribution, we present a brief overview about how interaction networks are derived from multivariate time series, about basic network characteristics, and about challenges associated with this analysis approach.}, language = {en} } @article{KozhalakovaZhubanovaMansurovetal.2010, author = {Kozhalakova, A. A. and Zhubanova, Azhar A. and Mansurov, Z. A. and Digel, Ilya and Tazhibayeva, S. M. and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Adsorption of bacterial lipopolysaccharides on carbonized rice shell}, series = {Science of Central Asia (2010)}, journal = {Science of Central Asia (2010)}, pages = {50 -- 54}, year = {2010}, language = {en} } @article{NgamgaBialonskiMarwanetal.2016, author = {Ngamga, Eulalie Joelle and Bialonski, Stephan and Marwan, Norbert and Kurths, J{\"u}rgen and Geier, Christian and Lehnertz, Klaus}, title = {Evaluation of selected recurrence measures in discriminating pre-ictal and inter-ictal periods from epileptic EEG data}, series = {Physics Letters A}, volume = {380}, journal = {Physics Letters A}, number = {16}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0375-9601}, doi = {10.1016/j.physleta.2016.02.024}, pages = {1419 -- 1425}, year = {2016}, abstract = {We investigate the suitability of selected measures of complexity based on recurrence quantification analysis and recurrence networks for an identification of pre-seizure states in multi-day, multi-channel, invasive electroencephalographic recordings from five epilepsy patients. We employ several statistical techniques to avoid spurious findings due to various influencing factors and due to multiple comparisons and observe precursory structures in three patients. Our findings indicate a high congruence among measures in identifying seizure precursors and emphasize the current notion of seizure generation in large-scale epileptic networks. A final judgment of the suitability for field studies, however, requires evaluation on a larger database.}, language = {en} } @inproceedings{StadlerEmbsZerlinetal.2007, author = {Stadler, Andreas M. and Embs, Jan P. and Zerlin, Kay and Digel, Ilya and Artmann, Gerhard and Zaccai, Joe and B{\"u}ldt, Georg}, title = {Temperature transitions of hemoglobin and cytosolic water diffusion in human red blood cells : [poster]}, year = {2007}, abstract = {Background Hemoglobin interactions in red blood cells Hemoglobin dynamics in human red blood cells Diffusion of H2O in red blood cells}, subject = {Erythrozyt}, language = {en} } @inproceedings{ArinkinDigel2009, author = {Arinkin, Vladimir and Digel, Ilya}, title = {Water bridge phenomenon : [abstract]}, year = {2009}, abstract = {One of interesting but not well known water properties is related to appearance of highly ordered structures in response to strong electrical field. In 1893 Sir William Armstrong placed a cotton thread between two wine glasses filled with chemically pure water. When high DC voltage was applied between the glasses, a connection consisting of water formed, producing a "water bridge"}, subject = {Hydrodynamik}, language = {en} } @article{LehnertzAnsmannBialonskietal.2014, author = {Lehnertz, Klaus and Ansmann, Gerrit and Bialonski, Stephan and Dickten, Henning and Geier, Christian and Porz, Stephan}, title = {Evolving networks in the human epileptic brain}, series = {Physica D: Nonlinear Phenomena}, volume = {267}, journal = {Physica D: Nonlinear Phenomena}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-2789}, doi = {10.1016/j.physd.2013.06.009}, pages = {7 -- 15}, year = {2014}, abstract = {Network theory provides novel concepts that promise an improved characterization of interacting dynamical systems. Within this framework, evolving networks can be considered as being composed of nodes, representing systems, and of time-varying edges, representing interactions between these systems. This approach is highly attractive to further our understanding of the physiological and pathophysiological dynamics in human brain networks. Indeed, there is growing evidence that the epileptic process can be regarded as a large-scale network phenomenon. We here review methodologies for inferring networks from empirical time series and for a characterization of these evolving networks. We summarize recent findings derived from studies that investigate human epileptic brain networks evolving on timescales ranging from few seconds to weeks. We point to possible pitfalls and open issues, and discuss future perspectives.}, language = {en} } @article{ArtmannZerlinDigel2008, author = {Artmann, Gerhard and Zerlin, Kay and Digel, Ilya}, title = {Hemoglobin Senses Body Temperature}, series = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, journal = {Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.)}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-75408-4}, pages = {415 -- 447}, year = {2008}, language = {en} } @article{MansurovJandosovKerimkulovaetal.2014, author = {Mansurov, Z. A. and Jandosov, J. M. and Kerimkulova, A. R. and Azat, S. and Zhubanova, A. A. and Digel, Ilya and Savistkaya, I. S. and Akimbekov, Nuraly S. and Kistaubaeva, A. S.}, title = {Nanostructured carbon materials for biomedical use}, series = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences}, volume = {15 (2013)}, journal = {Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences}, number = {3}, publisher = {Institute of Combustion Problems}, address = {Almaty}, issn = {1562-3920}, doi = {10.18321/ectj224}, pages = {209 -- 217}, year = {2014}, abstract = {One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials.}, language = {en} } @book{Bialonski2012, author = {Bialonski, Stephan}, title = {Inferring complex networks from time series of dynamical systems: Pitfalls, misinterpretations, and possible solutions}, publisher = {Universit{\"a}ts- und Landesbibliothek Bonn}, address = {Bonn}, pages = {Online-Ausgabe (III, 135 S. : Ill., graph. Darst.)}, year = {2012}, language = {en} } @article{BialonskiSchindlerElgeretal.2008, author = {Bialonski, Stephan and Schindler, K. and Elger, C. E. and Lehnertz, Klaus}, title = {Lateralized characteristics of the evolution of EEG correlation during focal onset seizures: a mechanism to prevent secondary generalization?}, series = {Epilepsia}, volume = {49}, journal = {Epilepsia}, issn = {0013-9580}, pages = {11 -- 11}, year = {2008}, abstract = {Rationale: Previous studies [Topolnik et al., Cereb Cortex 2003; 13: 883; Schindler et al., Brain 2007; 130: 65] indicate that the termination of focal onset seizures may be causally related to an increase of global neuronal correlation during the second half of the seizures. This increase was observed to occur earlier in complex partial seizures than in secondarily generalized seizures. We here address the question whether such an increase of neuronal correlation prior to seizure end is indeed a global phenomenon, involving both hemispheres or whether there are side-specific differences. Methods: We analyzed 20 focal onset seizures (10 complex partial, 10 secondarily generalized seizures) recorded in 13 patients who underwent presurgical evaluation of focal epilepsies of different origin. EEG was recorded intracranially from bilaterally implanted subdural strip and intrahippocampal depth electrodes. Utilizing a moving window approach, we investigated the evolution of the maximum cross correlation for all channel combinations during seizures. For each moving window the mean value of the maximum cross correlation (MCC) between all electrode contacts was computed separately for each hemisphere. After normalization of seizure durations, MCC values of the ipsi- and contralateral hemisphere for all seizures were determined. Results: We observed that the MCC of the contralateral hemisphere in complex partial seizures increased during the first half of the seizure, whereas, for the same time interval, the MCC of the ipsilateral hemisphere even declined below the level of the pre-seizure period. In contrast, no significant differences between both hemispheres could be observed for secondarily generalized seizures where both hemispheres showed a simultaneous increase of MCC during the second half of the seizures. The level of MCC for the contralateral hemisphere was higher for complex partial seizures than for secondarily generalized seizures during the first half of the seizure. Conclusions: Our findings indicate that there are indeed lateralized differences in the evolution of global neuronal correlation during complex partial and secondarily generalized seizures. The observed contralateral increase of neuronal correlation during complex partial seizures might indicate an emerging self-organizing mechanism for preventing the spread of seizure activity.}, language = {en} } @article{RuebbelkeVoegeleGrajewskietal.2023, author = {R{\"u}bbelke, Dirk and V{\"o}gele, Stefan and Grajewski, Matthias and Zobel, Luzy}, title = {Cross border adjustment mechanism: Initial data for the assessment of hydrogen-based steel production}, series = {Data in Brief}, volume = {47}, journal = {Data in Brief}, number = {Article 108907}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2352-3409}, doi = {10.1016/j.dib.2023.108907}, pages = {1 -- 5}, year = {2023}, abstract = {Ambitious climate targets affect the competitiveness of industries in the international market. To prevent such industries from moving to other countries in the wake of increased climate protection efforts, cost adjustments may become necessary. Their design requires knowledge of country-specific production costs. Here, we present country-specific cost figures for different production routes of steel, paying particular attention to transportation costs. The data can be used in floor price models aiming to assess the competitiveness of different steel production routes in different countries (R{\"u}bbelke, 2022).}, language = {en} } @article{TranKreissigVuetal.2008, author = {Tran, Thanh Ngoc and Kreißig, R. and Vu, Duc Khoi and Staat, Manfred}, title = {Upper bound limit and shakedown analysis of shells using the exact Ilyushin yield surface}, series = {Computer \& Structures. 86 (2008)}, journal = {Computer \& Structures. 86 (2008)}, isbn = {0045-7949}, pages = {1683 -- 1695}, year = {2008}, language = {en} } @article{JungMuellerStaat2018, author = {Jung, Alexander and M{\"u}ller, Wolfram and Staat, Manfred}, title = {Wind and fairness in ski jumping: A computer modelling analysis}, series = {Journal of Biomechanics}, journal = {Journal of Biomechanics}, number = {75}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2018.05.001}, pages = {147 -- 153}, year = {2018}, abstract = {Wind is closely associated with the discussion of fairness in ski jumping. To counter-act its influence on the jump length, the International Ski Federation (FIS) has introduced a wind compensation approach. We applied three differently accurate computer models of the flight phase with wind (M1, M2, and M3) to study the jump length effects of various wind scenarios. The previously used model M1 is accurate for wind blowing in direction of the flight path, but inaccuracies are to be expected for wind directions deviating from the tangent to the flight path. M2 considers the change of airflow direction, but it does not consider the associated change in the angle of attack of the skis which additionally modifies drag and lift area time functions. M3 predicts the length effect for all wind directions within the plane of the flight trajectory without any mathematical simplification. Prediction errors of M3 are determined only by the quality of the input data: wind velocity, drag and lift area functions, take-off velocity, and weight. For comparing the three models, drag and lift area functions of an optimized reference jump were used. Results obtained with M2, which is much easier to handle than M3, did not deviate noticeably when compared to predictions of the reference model M3. Therefore, we suggest to use M2 in future applications. A comparison of M2 predictions with the FIS wind compensation system showed substantial discrepancies, for instance: in the first flight phase, tailwind can increase jump length, and headwind can decrease it; this is opposite of what had been anticipated before and is not considered in the current wind compensation system in ski jumping.}, language = {en} } @article{StadlerDigelEmbsetal.2009, author = {Stadler, Andreas M. and Digel, Ilya and Embs, Jan P. and Unruh, Tobias and Tehei, M. and Zaccai, G. and B{\"u}ldt, G. and Artmann, Gerhard}, title = {From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature}, series = {Biophysical Journal. 96 (2009), H. 12}, journal = {Biophysical Journal. 96 (2009), H. 12}, publisher = {Cell Press}, address = {Cambridge, Mass.}, isbn = {0006-3495}, pages = {5073 -- 5081}, year = {2009}, language = {en} } @article{JungStaatMueller2018, author = {Jung, Alexander and Staat, Manfred and M{\"u}ller, Wolfram}, title = {Corrigendum to "Flight style optimization in ski jumping on normal, large, and ski flying hills" [J. Biomech 47 (2014) 716-722]}, series = {Journals of Biomechanics}, journal = {Journals of Biomechanics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0021-9290}, doi = {10.1016/j.jbiomech.2018.02.001}, pages = {313}, year = {2018}, language = {en} } @inproceedings{DuongNguyenStaat2012, author = {Duong, Minh Tuan and Nguyen, Nhu Hunyh and Staat, Manfred}, title = {Finite Element Implementation of a 3D Fung-type Model}, series = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, booktitle = {ESMC-2012 - 8th European Solid Mechanics Conference, Graz, Austria, July 9-13, 2012}, publisher = {Verlag d. Technischen Universit{\"a}t Graz}, address = {Graz}, isbn = {978-3-85125-223-1}, year = {2012}, language = {en} } @article{AkimbekovDigelOHerasetal.2014, author = {Akimbekov, Nuraly S. and Digel, Ilya and O´Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.}, title = {Adsorption of bacterial lipopolysaccharides on carbonized rice husks obtained in the batch experiments}, series = {Experimental Biology}, volume = {60}, journal = {Experimental Biology}, number = {1/2}, publisher = {Al-Farabi Kazakh National University}, address = {Almaty}, issn = {1563-0218}, pages = {144 -- 148}, year = {2014}, abstract = {The scope of this study is the measurement of endotoxin adsorption rate for carbonized rice husk. It showed good adsorption properties for LPS. During the batch experiments, several techniques were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics.}, language = {en} } @article{DigelTrzewikDemircietal.2004, author = {Digel, Ilya and Trzewik, J{\"u}rgen and Demirci, Taylan and Temiz Artmann, Ayseg{\"u}l}, title = {Response of fibroblasts to cyclic mechanical stress : a proteome approach / Digel, I. ; Trzewik, J. ; Demirci, T. ; Temiz Artmann, A. ; Artmann, G. M.}, series = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1042 -- 1043}, year = {2004}, language = {en} } @article{ArinkinDigelPorstetal.2014, author = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard}, title = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application}, series = {BMC bioinformatics}, volume = {15}, journal = {BMC bioinformatics}, number = {55}, issn = {1471-2105}, doi = {10.1186/1471-2105-15-55}, pages = {1 -- 8}, year = {2014}, abstract = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.}, language = {en} } @article{FrotscherKochStaat2015, author = {Frotscher, Ralf and Koch, Jan-Peter and Staat, Manfred}, title = {Computational investigation of drug action on human-induced stem cell derived cardiomyocytes}, series = {Journal of biomechanical engineering}, volume = {Vol. 137}, journal = {Journal of biomechanical engineering}, number = {iss. 7}, publisher = {ASME}, address = {New York}, issn = {1528-8951 (E-Journal); 0148-0731 (Print)}, doi = {10.1115/1.4030173}, pages = {071002-1 -- 071002-7}, year = {2015}, language = {en} } @article{Staat1993, author = {Staat, Manfred}, title = {Failure probabilities of the primary circuit pressure boundary of an HTR-Module for process heat generation under accident conditions for different failure modes}, series = {Nuclear Engineering and Design. 144 (1993), H. 1}, journal = {Nuclear Engineering and Design. 144 (1993), H. 1}, isbn = {0029-5493}, pages = {53 -- 67}, year = {1993}, language = {en} } @incollection{TranStaat2015, author = {Tran, Thanh Ngoc and Staat, Manfred}, title = {Uncertainty multimode failure and shakedown analysis of shells}, series = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...}, booktitle = {Direct methods for limit and shakedown analysis of structures / eds. Paolo Fuschi ...}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-12927-3 (print) ; 978-3-319-12928-0 (online)}, doi = {10.1007/978-3-319-12928-0_14}, pages = {279 -- 298}, year = {2015}, abstract = {This paper presents a numerical procedure for reliability analysis of thin plates and shells with respect to plastic collapse or to inadaptation. The procedure involves a deterministic shakedown analysis for each probabilistic iteration, which is based on the upper bound approach and the use of the exact Ilyushin yield surface. Probabilistic shakedown analysis deals with uncertainties originated from the loads, material strength and thickness of the shell. Based on a direct definition of the limit state function, the calculation of the failure probability may be efficiently solved by using the First and Second Order Reliability Methods (FORM and SORM). The problem of reliability of structural systems (series systems) is handled by the application of a special technique which permits to find all the design points corresponding to all the failure modes. Studies show, in this case, that it improves considerably the FORM and SORM results.}, language = {en} } @article{Staat2004, author = {Staat, Manfred}, title = {Plastic collapse analysis of longitudinally flawed pipes and vessels}, series = {Nuclear Engineering and Design. 234 (2004), H. 1-3}, journal = {Nuclear Engineering and Design. 234 (2004), H. 1-3}, isbn = {0029-5493}, pages = {25 -- 43}, year = {2004}, language = {en} } @article{LaackRefisch1986, author = {Laack, Walter van and Refisch, A.}, title = {Stellenwert der Kniegelenksarthroskopie aus diagnostischer und therapeutischer Sicht}, series = {Aktuelle Ergebnisse der Osteologie : Timmendorfer Strand, 21. - 23. November 1985 / hrsg. von P. Dietsch}, journal = {Aktuelle Ergebnisse der Osteologie : Timmendorfer Strand, 21. - 23. November 1985 / hrsg. von P. Dietsch}, publisher = {de Gruyter}, address = {Berlin}, isbn = {3-11-011147-0}, pages = {XIV, 343 S. : Ill., graph. Darst.}, year = {1986}, language = {de} } @article{StaatKuehnHaugeretal.2004, author = {Staat, Manfred and K{\"u}hn, R. and Hauger, W. and Sponagel, Stefan}, title = {An Interpretation of Wolff's Law}, series = {Biomedizinische Technik. 49 (2004)}, journal = {Biomedizinische Technik. 49 (2004)}, isbn = {0932-4666}, pages = {1020 -- 1021}, year = {2004}, language = {de} } @article{StaatVu2004, author = {Staat, Manfred and Vu, Duc-Khoi}, title = {An Algorithm for Shakedown Analysis for Materials with Temperature Dependent Yield Stress}, series = {Proceedings in Applied Mathematics and Mechanics (PAMM). 4 (2004), H. 1}, journal = {Proceedings in Applied Mathematics and Mechanics (PAMM). 4 (2004), H. 1}, isbn = {1617-7061}, pages = {231 -- 233}, year = {2004}, language = {en} } @article{Staat2005, author = {Staat, Manfred}, title = {Local and global collapse pressure of longitudinally flawed pipes and cylindrical vessels}, series = {International Journal of Pressure Vessels and Piping. 82 (2005), H. 3}, journal = {International Journal of Pressure Vessels and Piping. 82 (2005), H. 3}, isbn = {0308-0161}, pages = {217 -- 225}, year = {2005}, language = {en} } @inproceedings{LangWirtzHeitzeretal.1999, author = {Lang, H. and Wirtz, K. and Heitzer, Michael and Staat, Manfred and Oettel, R.}, title = {Zyklische Einspielversuche zur Verifikation von Shakedown-Analysen mittels FEM}, year = {1999}, abstract = {Im Rahmen von Erm{\"u}dungsanalysen ist nachzuweisen, daß die thermisch bedingten fortschreitenden Deformationen begrenzt bleiben. Hierzu ist die Abgrenzung des Shakedown-Bereiches (Einspielen) vom Ratchetting-Bereich (fortschreitende Deformation) von Interesse. Im Rahmen eines EU-gef{\"o}rderten Forschungsvorhabens wurden Experimente mit einem 4-Stab-Modell durchgef{\"u}hrt. Das Experiment bestand aus einem wassergek{\"u}hlten inneren Rohr und drei isolierten und beheizbaren {\"a}ußeren Probest{\"a}ben. Das System wurde durch alternierende Axialkr{\"a}fte, denen alternierende Temperaturen an den {\"a}ußeren St{\"a}ben {\"u}berlagert wurden, belastet. Die Versuchsparameter wurden teilweise nach vorausgegangenen Einspielanalysen gew{\"a}hlt. W{\"a}hrend der Versuchsdurchf{\"u}hrung wurden Temperaturen und Dehnungen zeitabh{\"a}ngig gemessen. Begleitend und nachfolgend zur Versuchsdurchf{\"u}hrung wurden die Belastungen und die daraus resultierenden Beanspruchungen nachvollzogen. Bei dieser inkrementellen elasto-plastischen Analyse mit dem Programm ANSYS wurden unterschiedliche Werkstoffmodelle angesetzt. Die Ergebnisse dieser Simulationsberechnung dienen dazu, die Shakedown-Analysen mittels FE-Methode zu verifizieren.}, subject = {Einspielen }, language = {de} } @article{PreissLinderWendtetal.2011, author = {Preiß, C. and Linder, Peter and Wendt, K. and Krystek, M. and Digel, Ilya and Gossmann, Matthias and Temiz Artmann, Ayseg{\"u}l and Porst, Dariusz and Kayser, Peter and Bassam, Rasha and Artmann, Gerhard}, title = {Engineering technology for plant physiology and plant stress research}, year = {2011}, abstract = {Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology.}, subject = {Pflanzenphysiologie}, language = {en} } @article{Laack1986, author = {Laack, Walter van}, title = {Einfluß osteopathisch manipulativer Techniken auf die Muskulatur: Elektromyographische Untersuchungen}, series = {Aktuelle Ergebnisse der Osteologie : Timmendorfer Strand, 21. - 23. November 1985 / hrsg. von P. Dietsch}, journal = {Aktuelle Ergebnisse der Osteologie : Timmendorfer Strand, 21. - 23. November 1985 / hrsg. von P. Dietsch}, publisher = {de Gruyter}, address = {Berlin}, isbn = {3-11-011147-0}, pages = {XIV, 343 S. : Ill., graph. Darst.}, year = {1986}, language = {de} } @inproceedings{BurgethKleefeldZhangetal.2022, author = {Burgeth, Bernhard and Kleefeld, Andreas and Zhang, Eugene and Zhang, Yue}, title = {Towards Topological Analysis of Non-symmetric Tensor Fields via Complexification}, series = {Discrete Geometry and Mathematical Morphology}, booktitle = {Discrete Geometry and Mathematical Morphology}, editor = {Baudrier, {\´E}tienne and Naegel, Beno{\^i}t and Kr{\"a}henb{\"u}hl, Adrien and Tajine, Mohamed}, publisher = {Springer}, address = {Cham}, isbn = {978-3-031-19897-7}, doi = {10.1007/978-3-031-19897-7_5}, pages = {48 -- 59}, year = {2022}, abstract = {Fields of asymmetric tensors play an important role in many applications such as medical imaging (diffusion tensor magnetic resonance imaging), physics, and civil engineering (for example Cauchy-Green-deformation tensor, strain tensor with local rotations, etc.). However, such asymmetric tensors are usually symmetrized and then further processed. Using this procedure results in a loss of information. A new method for the processing of asymmetric tensor fields is proposed restricting our attention to tensors of second-order given by a 2x2 array or matrix with real entries. This is achieved by a transformation resulting in Hermitian matrices that have an eigendecomposition similar to symmetric matrices. With this new idea numerical results for real-world data arising from a deformation of an object by external forces are given. It is shown that the asymmetric part indeed contains valuable information.}, language = {en} } @article{RuebbelkeVoegeleGrajewskietal.2022, author = {R{\"u}bbelke, Dirk and V{\"o}gele, Stefan and Grajewski, Matthias and Zobel, Luzy}, title = {Hydrogen-based steel production and global climate protection: An empirical analysis of the potential role of a European cross border adjustment mechanism}, series = {Journal of Cleaner Production}, volume = {380}, journal = {Journal of Cleaner Production}, number = {Part 2, Art. Nr.:135040}, publisher = {Elsevier}, issn = {0959-6526}, doi = {10.1016/j.jclepro.2022.135040}, year = {2022}, abstract = {The European Union's aim to become climate neutral by 2050 necessitates ambitious efforts to reduce carbon emissions. Large reductions can be attained particularly in energy intensive sectors like iron and steel. In order to prevent the relocation of such industries outside the EU in the course of tightening environmental regulations, the establishment of a climate club jointly with other large emitters and alternatively the unilateral implementation of an international cross-border carbon tax mechanism are proposed. This article focuses on the latter option choosing the steel sector as an example. In particular, we investigate the financial conditions under which a European cross border mechanism is capable to protect hydrogen-based steel production routes employed in Europe against more polluting competition from abroad. By using a floor price model, we assess the competitiveness of different steel production routes in selected countries. We evaluate the climate friendliness of steel production on the basis of specific GHG emissions. In addition, we utilize an input-output price model. It enables us to assess impacts of rising cost of steel production on commodities using steel as intermediates. Our results raise concerns that a cross-border tax mechanism will not suffice to bring about competitiveness of hydrogen-based steel production in Europe because the cost tends to remain higher than the cost of steel production in e.g. China. Steel is a classic example for a good used mainly as intermediate for other products. Therefore, a cross-border tax mechanism for steel will increase the price of products produced in the EU that require steel as an input. This can in turn adversely affect competitiveness of these sectors. Hence, the effects of higher steel costs on European exports should be borne in mind and could require the cross-border adjustment mechanism to also subsidize exports.}, language = {en} } @book{Laack2001, author = {Laack, Walter van}, title = {Eine bessere Geschichte unserer Welt / Bd. 2. Das Leben}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-8311-2114-4}, pages = {248 S.}, year = {2001}, language = {de} } @inproceedings{StaatHeitzer1997, author = {Staat, Manfred and Heitzer, Michael}, title = {Direkte FEM-Berechnung der Tragf{\"a}higkeit hochbeanspruchter passiver Komponenten}, year = {1997}, abstract = {Genaue Kenntnis der Spannungen und Verformungen in passiven Komponenten gewinnt man mit detailierten inelastischen FEM Analysen. Die lokale Beanspruchung l{\"a}ßt sich aber nicht direkt mit einer Beanspruchbarkeit im strukturmechanischen Sinne vergleichen. Konzentriert man sich auf die Frage nach der Tragf{\"a}higkeit, dann vereinfacht sich die Analyse. Im Rahmen der Plastizit{\"a}tstheorie berechnen Traglast- und Einspielanalyse die tragbaren Lasten direkt und exakt. In diesem Beitrag wird eine Implementierung der Traglast- und Einspiels{\"a}tze in ein allgemeines FEM Programm vorgestellt, mit der die Tragf{\"a}higkeit passiver Komponenten direkt berechnet wird. Die benutzten Konzepte werden in Bezug auf die {\"u}bliche Strukturanalyse erl{\"a}utert. Beispiele mit lokal hoher Beanspruchung verdeutlichen die Anwendung der FEM basierten Traglast- und Einspielanalysen. Die berechneten Interaktionsdiagramme geben einen guten {\"U}berblick {\"u}ber die m{\"o}glichen Betriebsbereiche passiver Komponenten. Die Traglastanalyse bietet auch einen strukturmechanischen Zugang zur Kollapslast rißbehafteter Komponenten aus hochz{\"a}hem Material.}, subject = {Finite-Elemente-Methode}, language = {de} } @inproceedings{BurgazziFioriniDeMagistrisetal.1998, author = {Burgazzi, L. and Fiorini, F. and De Magistris, W. (u.a.) and Lensa, W. von and Staat, Manfred and Altes, J.}, title = {Reliability Assessment of Passive Safety Systems}, series = {Proceedings of the 6th International Conference on Nuclear Engineering : ICONE : May 10 - 14, 1998, San Diego, Calif.}, booktitle = {Proceedings of the 6th International Conference on Nuclear Engineering : ICONE : May 10 - 14, 1998, San Diego, Calif.}, publisher = {American Society of Mechanical Engineers}, address = {New York}, year = {1998}, language = {en} } @book{Stulpe1986, author = {Stulpe, Werner}, title = {Bedingte Erwartungen und stochastische Prozesse in der generalisierten Wahrscheinlichkeitstheorie : Beschreibung sukzessiver Messungen mit zuf{\"a}lligem Ausgang}, address = {Berlin}, pages = {199 S.}, year = {1986}, language = {de} }