@article{WerkhausenAlbrachtCroninetal.2018,
  author    = {Werkhausen, Amelie and Albracht, Kirsten and Cronin, Neil J and Paulsen, G{\o}ran and Bojsen-M{\o}ller, Jens and Seynnes, Olivier R},
  title     = {Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing},
  series = {Frontiers in physiology},
  journal   = {Frontiers in physiology},
  number    = {9},
  publisher = {Frontiers Research Foundation},
  address   = {Lausanne},
  issn      = {1664-042X},
  doi       = {10.3389/fphys.2018.00794},
  pages     = {11 Seiten},
  year      = {2018},
  abstract  = {During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18\%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8\%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21\%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation.},
  language  = {en}
}
@article{YangKriechbaumerAlbrachtetal.2014,
  author    = {Yang, Peng-Fei and Kriechbaumer, Andreas and Albracht, Kirsten and Sanno, Maximilian and Ganse, Bergita and Koy, Timmo and Shang, Peng and br{\"u}ggemann, Gert-Peter and M{\"u}ller, Lars Peter and Rittweger, J{\"o}rn},
  title     = {A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans},
  series = {Journal of Orthopaedic Translation},
  volume    = {2},
  journal   = {Journal of Orthopaedic Translation},
  number    = {4},
  publisher = {Elsevier},
  address   = {Singapore},
  issn      = {2214-0328},
  doi       = {10.1016/j.jot.2014.07.078},
  pages     = {238 -- 238},
  year      = {2014},
  language  = {en}
}
@misc{OPUS4-10951,
  title     = {Richtlinie zur Durchf{\"u}hrung von Sonderveranstaltungen in den Geb{\"a}uden und Liegenschaften der FH Aachen (Veranstaltungsrichtlinie) : vom 20. November 2019},
  organization    = {FH Aachen},
  pages     = {21 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10952,
  title     = {Richtlinie zur Durchf{\"u}hrung von Sonderveranstaltungen in den Geb{\"a}uden und Liegenschaften der FH Aachen (Veranstaltungsrichtlinie) : vom 20. November 2019 Anlage 1 aktualisiert am 22. Januar 2020},
  organization    = {FH Aachen},
  pages     = {21 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10953,
  title     = {Richtlinie f{\"u}r die Besch{\"a}ftigung und Verg{\"u}tung studentischer und wissenschaftlicher Hilfskr{\"a}fte an der Fachhochschule Aachen : vom 20. November 2019},
  organization    = {FH Aachen},
  pages     = {6 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10954,
  title     = {Richtlinie f{\"u}r die Besch{\"a}ftigung und Verg{\"u}tung studentischer und wissenschaftlicher Hilfskr{\"a}fte an der Fachhochschule Aachen : vom 20. November 2019 aktualisiert am 24. November 2022},
  organization    = {FH Aachen},
  pages     = {6 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10955,
  title     = {Gleichstellungsquoten der FH Aachen f{\"u}r die Jahre 2019 -2021 : vom 20. November 2019},
  organization    = {FH Aachen},
  pages     = {2 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10956,
  title     = {Ordnung zur Aufhebung der Pr{\"u}fungsordnungen f{\"u}r den Masterstudiengang „Nuclear Applications" vom 13. Februar 2004 (FH-Mitteilung Nr. 5/2004) und vom 25. Februar 2010 (FH-Mitteilung Nr. 15/2010) in den Fassungen der Bekanntmachung der {\"A}nderungsordnungen vom 6. November 2012 (FH-Mitteilung Nr. 120/2012), 18. Juni 2014 (FH- Mitteilung Nr. 72/2014) und vom 15. Juni 2015 (FH-Mitteilung Nr. 28/2015) : vom 29. November 2019},
  organization    = {FH Aachen},
  pages     = {3 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10957,
  title     = {5. Ordnung zur {\"A}nderung der Pr{\"u}fungsordnung f{\"u}r die Bachelorstudieng{\"a}nge „Betriebswirtschaft Praxis Plus" und „Betriebswirtschaft Praxis Plus (Teilzeit)" mit dem Studienabschluss „Bachelor of Science" am Fachbereich Wirtschaftswissenschaften der Fachhochschule Aachen (PO - BWL Praxis Plus) : vom 29. November 2019},
  organization    = {FH Aachen},
  pages     = {2 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10958,
  title     = {Pr{\"u}fungsordnung f{\"u}r die Bachelorstudieng{\"a}nge „Betriebswirtschaft Praxis Plus" und „Betriebswirtschaft Praxis Plus (Teilzeit)" mit dem Studienabschluss „Bachelor of Science" am Fachbereich Wirtschaftswissenschaften der Fachhochschule Aachen (PO-BWL Praxis Plus) : vom 14. Januar 2014 - FH-Mitteilung Nr. 2/2014 in der Fassung der Bekanntmachung der {\"A}nderungsordnung vom 29. November 2019 - FH-Mitteilung Nr. 128/2019 (Nichtamtliche lesbare Fassung | Studienbeginn ab WS 2019/20)},
  organization    = {FH Aachen},
  pages     = {11 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10959,
  title     = {2. {\"A}nderung der Richtlinie des Rektorats der FH Aachen f{\"u}r die Vergabe von Lehrveranstaltungspr{\"a}mien : vom 13. Dezember 2019},
  organization    = {FH Aachen},
  pages     = {2 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10960,
  title     = {Richtlinie des Rektorats der FH Aachen f{\"u}r die Vergabe von Lehrveranstaltungspr{\"a}mien : vom 16. Juli 2012 - FH-Mitteilung Nr. 68/2012 in der Fassung der Bekanntmachung der {\"A}nderung vom 13. Dezember 2019 - FH-Mitteilung Nr. 130/2019 (Nichtamtliche lesbare Fassung)},
  organization    = {FH Aachen},
  pages     = {3 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10961,
  title     = {Pr{\"u}fungsordnung f{\"u}r den Masterstudiengang Nuclear Applications im Fachbereich Chemie und Biotechnologie an der Fachhochschule Aachen : vom 17. Dezember 2019},
  organization    = {FH Aachen},
  pages     = {7 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10962,
  title     = {Ordnung zur Aufhebung der Pr{\"u}fungsordnung f{\"u}r den Masterstudiengang „Information Systems Engineering" vom 22. Januar 2010 (FH-Mitteilung Nr. 5/2010), zuletzt ge{\"a}ndert durch {\"A}nderungsordnung vom 4. Februar 2013 (FH-Mitteilung Nr. 6/2013) : vom 20. Dezember 2019},
  organization    = {FH Aachen},
  pages     = {3 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10963,
  title     = {Ordnung zur Aufhebung der Pr{\"u}fungsordnung f{\"u}r den Masterstudiengang „Elektrotechnik" (zuvor „Nachrichtentechnik" und „Elektrotechnik und Informationstechnik") vom 22. Januar 2010 (FH-Mitteilung Nr. 7/2010), zuletzt ge{\"a}ndert durch {\"A}nderungsordnung vom 25. April 2016 (FH-Mitteilung Nr. 31/2016) : vom 20. Dezember 2019},
  organization    = {FH Aachen},
  pages     = {3 Seiten},
  year      = {2019},
  language  = {de}
}
@misc{OPUS4-10964,
  title     = {Ordnung zur Aufhebung der Pr{\"u}fungsordnung f{\"u}r die Masterstudieng{\"a}nge „Energiewirtschaft \& Informatik" (3 Semester) und „Energiewirtschaft \& Informatik" (4 Semester) vom 4. Mai 2016 (FH-Mitteilung Nr. 59/2016) Fachbereich Energietechnik Fachbereich Medizintechnik und Technomathematik an der Fachhochschule Aachen : vom 16. Januar 2020},
  organization    = {FH Aachen},
  pages     = {3 Seiten},
  year      = {2020},
  language  = {de}
}
@misc{OPUS4-10965,
  title     = {Verwaltungs- und Benutzungsordnung des Solar-Instituts J{\"u}lich (SIJ) : vom 27. Januar 2020},
  organization    = {FH Aachen},
  pages     = {5 Seiten},
  year      = {2020},
  language  = {de}
}
@misc{OPUS4-10966,
  title     = {Verwaltungs- und Benutzungsordnung des Solar-Instituts J{\"u}lich (SIJ) vom 27. Januar 2020 : berichtigt durch Bekanntmachung vom 18. M{\"a}rz 2020 (FH-Mitteilung Nr. 27/2020)},
  organization    = {FH Aachen},
  pages     = {5 Seiten},
  year      = {2020},
  language  = {de}
}
@inproceedings{MaurerMiskiwAcostaetal.2023,
  author    = {Maurer, Florian and Miskiw, Kim K. and Acosta, Rebeca Ramirez and Harder, Nick and Sander, Volker and Lehnhoff, Sebastian},
  title     = {Market abstraction of energy markets and policies - application in an agent-based modeling toolbox},
  series = {EI.A 2023: Energy Informatics},
  booktitle = {EI.A 2023: Energy Informatics},
  editor    = {Jorgensen, Bo Norregaard and Pereira da Silva, Luiz Carlos and Ma, Zheng},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-031-48651-7 (Print)},
  doi       = {10.1007/978-3-031-48652-4_10},
  pages     = {139 -- 157},
  year      = {2023},
  abstract  = {In light of emerging challenges in energy systems, markets are prone to changing dynamics and market design. Simulation models are commonly used to understand the changing dynamics of future electricity markets. However, existing market models were often created with specific use cases in mind, which limits their flexibility and usability. This can impose challenges for using a single model to compare different market designs. This paper introduces a new method of defining market designs for energy market simulations. The proposed concept makes it easy to incorporate different market designs into electricity market models by using relevant parameters derived from analyzing existing simulation tools, morphological categorization and ontologies. These parameters are then used to derive a market abstraction and integrate it into an agent-based simulation framework, allowing for a unified analysis of diverse market designs. Furthermore, we showcase the usability of integrating new types of long-term contracts and over-the-counter trading. To validate this approach, two case studies are demonstrated: a pay-as-clear market and a pay-as-bid long-term market. These examples demonstrate the capabilities of the proposed framework.},
  language  = {en}
}
@techreport{AlbrachtRitzmannKrameretal.2017,
  author    = {Albracht, Kirsten and Ritzmann, Ramona and Kramer, Andreas and Meskemper, Joshua and St{\"a}udle, Benjamin and K{\"u}mmel, Jacob and Freyler, Katrin and Felsenberg, Dieter and Gruber, Marksu and Gollhofer, Albert and Belavy, Daniel},
  title     = {Vorhaben: Muskelkraftgenerierungsf{\"a}higkeit in Mikrogravitation},
  publisher = {Deutsche Sporthochschule K{\"o}ln},
  address   = {Kl{\"o}n},
  doi       = {10.2314/KXP:1670327353},
  pages     = {23 Seiten},
  year      = {2017},
  language  = {de}
}
@inproceedings{SchulzeBuxlohGross2021,
  author    = {Schulze-Buxloh, Lina and Groß, Rolf Fritz},
  title     = {Interdisciplinary Course Smart Building Engineering: A new approach of teaching freshmen in remote teamwork project under pandemic restrictions},
  series = {New Perspectives in Science Education - International Conference},
  booktitle = {New Perspectives in Science Education - International Conference},
  publisher = {Filodiritto},
  address   = {Bologna},
  pages     = {4 Seiten},
  year      = {2021},
  abstract  = {In the context of the Corona pandemic and its impact on teaching like digital lectures and exercises a new concept especially for freshmen in demanding courses of Smart Building Engineering became necessary. As there were hardly any face-to-face events at the university, the new teaching concept should enable a good start into engineering studies under pandemic conditions anyway and should also replace the written exam at the end. The students should become active themselves in small teams instead of listening passively to a lecture broadcast online with almost no personal contact. For this purpose, a role play was developed in which the freshmen had to work out a complete solution to the realistic problem of designing, construction planning and implementing a small guesthouse. Each student of the team had to take a certain role like architect, site manager, BIM-manager, electrician and the technitian for HVAC installations. Technical specifications must be complied with, as well as documentation, time planning and cost estimate. The final project folder had to contain technical documents like circuit diagrams for electrical components, circuit diagrams for water and heating, design calculations and components lists. On the other hand construction schedule, construction implementation plan, documentation of the construction progress and minutes of meetings between the various trades had to be submitted as well. In addition to the project folder, a model of the construction project must also be created either as a handmade model or as a digital 3D-model using Computer-aided design (CAD) software. The first steps in the field of Building information modelling (BIM) had also been taken by creating a digital model of the building showing the current planning status in real time as a digital twin. This project turned out to be an excellent training of important student competencies like teamwork, communication skills, and self -organisation and also increased motivation to work on complex technical questions. The aim of giving the student a first impression on the challenges and solutions in building projects with many different technical trades and their points of view was very well achieved and should be continued in the future.},
  language  = {en}
}
@inproceedings{SchulzeBuxlohGross2021,
  author    = {Schulze-Buxloh, Lina and Groß, Rolf Fritz},
  title     = {Miniature urban farming plant: a complex educational "Toy" for engineering students},
  series = {The Future of Education 11th Edition 2021},
  booktitle = {The Future of Education 11th Edition 2021},
  pages     = {4 Seiten},
  year      = {2021},
  abstract  = {Urban farming is an innovative and sustainable way of food production and is becoming more and more important in smart city and quarter concepts. It also enables the production of certain foods in places where they usually dare not produced, such as production of fish or shrimps in large cities far away from the coast. Unfortunately, it is not always possible to show students such concepts and systems in real life as part of courses: visits of such industry plants are sometimes not possible because of distance or are permitted by the operator for hygienic reasons. In order to give the students the opportunity of getting into contact with such an urban farming system and its complex operation, an industrial urban farming plant was set up on a significantly smaller scale. Therefore, all needed technical components like water aeriation, biological and mechanical filtration or water circulation have been replaced either by aquarium components or by self-designed parts also using a 3D-printer. Students from different courses like mechanical engineering, smart building engineering, biology, electrical engineering, automation technology and civil engineering were involved in this project. This "miniature industrial plant" was also able to start operation and has now been running for two years successfully. Due to Corona pandemic, home office and remote online lectures, the automation of this miniature plant should be brought to a higher level in future for providing a good control over the system and water quality remotely. The aim of giving the student a chance to get to know the operation of an urban farming plant was very well achieved and the students had lots of fun in "playing" and learning with it in a realistic way.},
  language  = {en}
}
@inproceedings{SchulzeBuxlohGrossUlbrich2021,
  author    = {Schulze-Buxloh, Lina and Groß, Rolf Fritz and Ulbrich, Michelle},
  title     = {Digital planning using building information modelling and virtual reality: new approach for students' remote practical training under lockdown conditions in the course of smart building engineering},
  series = {Proceedings of International Conference on Education in Mathematics, Science and Technology 2021},
  booktitle = {Proceedings of International Conference on Education in Mathematics, Science and Technology 2021},
  publisher = {ISTES Organization},
  address   = {San Antonio, TX},
  isbn      = {978-1-952092-17-6},
  pages     = {118 -- 123},
  year      = {2021},
  abstract  = {The worldwide Corona pandemic has severely restricted student projects in the higher semesters of engineering courses. In order not to delay the graduation, a new concept had to be developed for projects under lockdown conditions. Therefore, unused rooms at the university should be digitally recorded in order to develop a new usage concept as laboratory rooms. An inventory of the actual state of the rooms was done first by taking photos and listing up all flaws and peculiarities. After that, a digital site measuring was done with a 360° laser scanner and these recorded scans were linked to a coherent point cloud and transferred to a software for planning technical building services and supporting Building Information Modelling (BIM). In order to better illustrate the difference between the actual and target state, two virtual reality models were created for realistic demonstration. During the project, the students had to go through the entire digital planning phases. Technical specifications had to be complied with, as well as documentation, time planning and cost estimate. This project turned out to be an excellent alternative to on-site practical training under lockdown conditions and increased the students' motivation to deal with complex technical questions.},
  language  = {en}
}
@misc{SchulzeBuxlohGrossCheng2020,
  author    = {Schulze-Buxloh, Lina and Groß, Rolf Fritz and Cheng, Kevin Toni},
  title     = {Development and manufacturing of an interactive three-dimensional phase diagram of carbon dioxide for teaching sessions in thermodynamics},
  series = {Proceedings of the International Conference The Future of Education 2020},
  journal   = {Proceedings of the International Conference The Future of Education 2020},
  year      = {2020},
  language  = {en}
}
@inproceedings{BedburMoorkampPetersonetal.2020,
  author    = {Bedbur, Christian and Moorkamp, Wilfried and Peterson, Leif Arne and Uibel, Thomas},
  title     = {Holzbr{\"u}cken mit Natursteinbel{\"a}gen - Untersuchungen zur Aktivierung der Verbundwirkung},
  series = {Doktorandenkolloquium Holzbau Forschung + Praxis 2020},
  booktitle = {Doktorandenkolloquium Holzbau Forschung + Praxis 2020},
  editor    = {Kuhlmann, Ulrike},
  publisher = {Universit{\"a}t Stuttgart, Institut f{\"u}r Konstruktion und Entwurf},
  address   = {Stuttgart},
  pages     = {53 -- 60},
  year      = {2020},
  language  = {de}
}
@article{AngermannGuenthnerHanssenetal.2022,
  author    = {Angermann, Susanne and G{\"u}nthner, Roman and Hanssen, Henner and Lorenz, Georg and Braunisch, Matthias C. and Steubl, Dominik and Matschkal, Julia and Kemmner, Stephan and Hausinger, Renate and Block, Zenonas and Haller, Bernhard and Heemann, Uwe and Kotliar, Konstantin and Grimmer, Timo and Schmaderer, Christoph},
  title     = {Cognitive impairment and microvascular function in end-stage renal disease},
  series = {International Journal of Methods in Psychiatric Research (MPR)},
  volume    = {31},
  journal   = {International Journal of Methods in Psychiatric Research (MPR)},
  number    = {2},
  publisher = {Wiley},
  issn      = {1049-8931 (Print)},
  doi       = {10.1002/mpr.1909},
  pages     = {1 -- 10},
  year      = {2022},
  abstract  = {Objective Hemodialysis patients show an approximately threefold higher prevalence of cognitive impairment compared to the age-matched general population. Impaired microcirculatory function is one of the assumed causes. Dynamic retinal vessel analysis is a quantitative method for measuring neurovascular coupling and microvascular endothelial function. We hypothesize that cognitive impairment is associated with altered microcirculation of retinal vessels. Methods 152 chronic hemodialysis patients underwent cognitive testing using the Montreal Cognitive Assessment. Retinal microcirculation was assessed by Dynamic Retinal Vessel Analysis, which carries out an examination recording retinal vessels' reaction to a flicker light stimulus under standardized conditions. Results In unadjusted as well as in adjusted linear regression analyses a significant association between the visuospatial executive function domain score of the Montreal Cognitive Assessment and the maximum arteriolar dilation as response of retinal arterioles to the flicker light stimulation was obtained. Conclusion This is the first study determining retinal microvascular function as surrogate for cerebral microvascular function and cognition in hemodialysis patients. The relationship between impairment in executive function and reduced arteriolar reaction to flicker light stimulation supports the involvement of cerebral small vessel disease as contributing factor for the development of cognitive impairment in this patient population and might be a target for noninvasive disease monitoring and therapeutic intervention.},
  language  = {en}
}
@article{KotliarOrtnerConradietal.2022,
  author    = {Kotliar, Konstantin and Ortner, Marion and Conradi, Anna and Hacker, Patricia and Hauser, Christine and G{\"u}nthner, Roman and Moser, Michaela and Muggenthaler, Claudia and Diehl-Schmid, Janine and Priller, Josef and Schmaderer, Christoph and Grimmer, Timo},
  title     = {Altered retinal cerebral vessel oscillation frequencies in Alzheimer's disease compatible with impaired amyloid clearance},
  series = {Neurobiology of Aging},
  volume    = {120},
  journal   = {Neurobiology of Aging},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0197-4580},
  doi       = {10.1016/j.neurobiolaging.2022.08.012},
  pages     = {117 -- 127},
  year      = {2022},
  abstract  = {Retinal vessels are similar to cerebral vessels in their structure and function. Moderately low oscillation frequencies of around 0.1 Hz have been reported as the driving force for paravascular drainage in gray matter in mice and are known as the frequencies of lymphatic vessels in humans. We aimed to elucidate whether retinal vessel oscillations are altered in Alzheimer's disease (AD) at the stage of dementia or mild cognitive impairment (MCI). Seventeen patients with mild-to-moderate dementia due to AD (ADD); 23 patients with MCI due to AD, and 18 cognitively healthy controls (HC) were examined using Dynamic Retinal Vessel Analyzer. Oscillatory temporal changes of retinal vessel diameters were evaluated using mathematical signal analysis. Especially at moderately low frequencies around 0.1 Hz, arterial oscillations in ADD and MCI significantly prevailed over HC oscillations and correlated with disease severity. The pronounced retinal arterial vasomotion at moderately low frequencies in the ADD and MCI groups would be compatible with the view of a compensatory upregulation of paravascular drainage in AD and strengthen the amyloid clearance hypothesis.},
  language  = {en}
}
@article{NeumaierWeissVeldemanetal.2021,
  author    = {Neumaier, Felix and Weiss, Miriam and Veldeman, Michael and Kotliar, Konstantin and Wiesmann, Martin and Schulze-Steinen, Henna and H{\"o}llig, Anke and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid},
  title     = {Changes in endogenous daytime melatonin levels after aneurysmal subarachnoid hemorrhage - preliminary findings from an observational cohort study},
  series = {Clinical Neurology and Neurosurgery},
  volume    = {208},
  journal   = {Clinical Neurology and Neurosurgery},
  number    = {Article No.: 106870},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0303-8467},
  doi       = {10.1016/j.clineuro.2021.106870},
  year      = {2021},
  abstract  = {Aneurysmal subarachnoid hemorrhage (aSAH) is associated with early and delayed brain injury due to several underlying and interrelated processes, which include inflammation, oxidative stress, endothelial, and neuronal apoptosis. Treatment with melatonin, a cytoprotective neurohormone with anti-inflammatory, anti-oxidant and anti-apoptotic effects, has been shown to attenuate early brain injury (EBI) and to prevent delayed cerebral vasospasm in experimental aSAH models. Less is known about the role of endogenous melatonin for aSAH outcome and how its production is altered by the pathophysiological cascades initiated during EBI. In the present observational study, we analyzed changes in melatonin levels during the first three weeks after aSAH.},
  language  = {en}
}
@article{AlnemerKotliarNeuhausetal.2023,
  author    = {Alnemer, Momin Sami Mohammad and Kotliar, Konstantin and Neuhaus, Valentin and Pape, Hans-Christoph and Ciritsis, Bernhard D.},
  title     = {Cost-effectiveness analysis of surgical proximal femur fracture prevention in elderly: a Markov cohort simulation model},
  series = {Cost Effectiveness and Resource Allocation},
  journal   = {Cost Effectiveness and Resource Allocation},
  number    = {21, Article number: 77},
  publisher = {Springer Nature},
  issn      = {1478-7547},
  doi       = {10.1186/s12962-023-00482-4},
  pages     = {12 Seiten},
  year      = {2023},
  abstract  = {Background Hip fractures are a common and costly health problem, resulting in significant morbidity and mortality, as well as high costs for healthcare systems, especially for the elderly. Implementing surgical preventive strategies has the potential to improve the quality of life and reduce the burden on healthcare resources, particularly in the long term. However, there are currently limited guidelines for standardizing hip fracture prophylaxis practices. Methods This study used a cost-effectiveness analysis with a finite-state Markov model and cohort simulation to evaluate the primary and secondary surgical prevention of hip fractures in the elderly. Patients aged 60 to 90 years were simulated in two different models (A and B) to assess prevention at different levels. Model A assumed prophylaxis was performed during the fracture operation on the contralateral side, while Model B included individuals with high fracture risk factors. Costs were obtained from the Centers for Medicare \& Medicaid Services, and transition probabilities and health state utilities were derived from available literature. The baseline assumption was a 10\% reduction in fracture risk after prophylaxis. A sensitivity analysis was also conducted to assess the reliability and variability of the results. Results With a 10\% fracture risk reduction, model A costs between \$8,850 and \$46,940 per quality-adjusted life-year (\$/QALY). Additionally, it proved most cost-effective in the age range between 61 and 81 years. The sensitivity analysis established that a reduction of ≥ 2.8\% is needed for prophylaxis to be definitely cost-effective. The cost-effectiveness at the secondary prevention level was most sensitive to the cost of the contralateral side's prophylaxis, the patient's age, and fracture treatment cost. For high-risk patients with no fracture history, the cost-effectiveness of a preventive strategy depends on their risk profile. In the baseline analysis, the incremental cost-effectiveness ratio at the primary prevention level varied between \$11,000/QALY and \$74,000/QALY, which is below the defined willingness to pay threshold. Conclusion Due to the high cost of hip fracture treatment and its increased morbidity, surgical prophylaxis strategies have demonstrated that they can significantly relieve the healthcare system. Various key assumptions facilitated the modeling, allowing for adequate room for uncertainty. Further research is needed to evaluate health-state-associated risks.},
  language  = {en}
}
@article{KuchlerGuenthnerRibeiroetal.2023,
  author    = {Kuchler, Timon and G{\"u}nthner, Roman and Ribeiro, Andrea and Hausinger, Renate and Streese, Lukas and W{\"o}hnl, Anna and Kesseler, Veronika and Negele, Johanna and Assali, Tarek and Carbajo-Lozoya, Javier and Lech, Maciej and Adorjan, Kristina and Stubbe, Hans Christian and Hanssen, Henner and Kotliar, Konstantin and Haller, Berhard and Heemann, Uwe and Schmaderer, Christoph},
  title     = {Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation},
  volume    = {26},
  publisher = {Springer Nature},
  address   = {Dordrecht},
  doi       = {10.1007/s10456-023-09885-6},
  pages     = {547 -- 563},
  year      = {2023},
  abstract  = {Background Post-COVID-19 syndrome (PCS) is a lingering disease with ongoing symptoms such as fatigue and cognitive impairment resulting in a high impact on the daily life of patients. Understanding the pathophysiology of PCS is a public health priority, as it still poses a diagnostic and treatment challenge for physicians. Methods In this prospective observational cohort study, we analyzed the retinal microcirculation using Retinal Vessel Analysis (RVA) in a cohort of patients with PCS and compared it to an age- and gender-matched healthy cohort (n = 41, matched out of n = 204). Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vFID; 3.42\% ± 1.77\% vs. 4.64\% ± 2.59\%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5-190.2] vs. 189.1 [179.4-197.2], p = 0.01) and lower arteriolar-venular ratio (AVR; (0.84 [0.8-0.9] vs. 0.88 [0.8-0.9], p = 0.007). When combining AVR and vFID, predicted scores reached good ability to discriminate groups (area under the curve: 0.75). Higher PCS severity scores correlated with lower AVR (R = - 0.37 p = 0.017). The association of microvascular changes with PCS severity were amplified in PCS patients exhibiting higher levels of inflammatory parameters. Conclusion Our results demonstrate that prolonged endothelial dysfunction is a hallmark of PCS, and impairments of the microcirculation seem to explain ongoing symptoms in patients. As potential therapies for PCS emerge, RVA parameters may become relevant as clinical biomarkers for diagnosis and therapy management.},
  language  = {en}
}
@article{KuertenKotliarFuestetal.2021,
  author    = {Kuerten, David and Kotliar, Konstantin and Fuest, Matthias and Walter, Peter and Hollstein, Muriel and Plange, Niklas},
  title     = {Does hemispheric vascular regulation differ significantly in glaucoma patients with altitudinal visual field asymmetry? A single-center, prospective study},
  series = {International Ophthalmology},
  volume    = {41},
  journal   = {International Ophthalmology},
  number    = {41},
  editor    = {Neri, Piergiorgio},
  publisher = {Springer},
  address   = {Berlin},
  isbn      = {1573-2630},
  doi       = {10.1007/s10792-021-01876-0},
  pages     = {3109 -- 3119},
  year      = {2021},
  abstract  = {Purpose Vascular risk factors and ocular perfusion are heatedly discussed in the pathogenesis of glaucoma. The retinal vessel analyzer (RVA, IMEDOS Systems, Germany) allows noninvasive measurement of retinal vessel regulation. Significant differences especially in the veins between healthy subjects and patients suffering from glaucoma were previously reported. In this pilot-study we investigated if localized vascular regulation is altered in glaucoma patients with altitudinal visual field defect asymmetry. Methods 15 eyes of 12 glaucoma patients with advanced altitudinal visual field defect asymmetry were included. The mean defect was calculated for each hemisphere separately (-20.99 ± 10.49 pro- found hemispheric visual field defect vs -7.36 ± 3.97 dB less profound hemisphere). After pupil dilation, RVA measurements of retinal arteries and veins were conducted using the standard protocol. The superior and inferior retinal vessel reactivity were measured consecutively in each eye. Results Significant differences were recorded in venous vessel constriction after flicker light stimulation and overall amplitude of the reaction (p \ 0.04 and p \ 0.02 respectively) in-between the hemispheres spheres. Vessel reaction was higher in the hemisphere corresponding to the more advanced visual field defect. Arterial diameters reacted similarly, failing to reach statistical significance. Conclusion Localized retinal vessel regulation is significantly altered in glaucoma patients with asymmetri altitudinal visual field defects. Veins supplying the hemisphere concordant to a less profound visual field defect show diminished diameter changes. Vascular dysregulation might be particularly important in early glaucoma stages prior to a significant visual field defect.},
  language  = {en}
}
@article{AlbannaConzenWeissetal.2021,
  author    = {Albanna, Walid and Conzen, Catharina and Weiss, Miriam and Seyfried, Katharina and Kotliar, Konstantin and Schmidt, Tobias Philip and Kuerten, David and Hescheler, J{\"u}rgen and Bruecken, Anne and Schmidt-Trucks{\"a}ss, Arno and Neumaier, Felix and Wiesmann, Martin and Clusmann, Hans and Schubert, Gerrit Alexander},
  title     = {Non-invasive assessment of neurovascular coupling after aneurysmal subarachnoid hemorrhage: a prospective observational trial using retinal vessel analysis},
  series = {Frontiers in Neurology},
  volume    = {12},
  journal   = {Frontiers in Neurology},
  number    = {12},
  issn      = {1664-2295},
  doi       = {10.3389/fneur.2021.690183},
  pages     = {1 -- 15},
  year      = {2021},
  abstract  = {Delayed cerebral ischemia (DCI) is a common complication after aneurysmal subarachnoid hemorrhage (aSAH) and can lead to infarction and poor clinical outcome. The underlying mechanisms are still incompletely understood, but animal models indicate that vasoactive metabolites and inflammatory cytokines produced within the subarachnoid space may progressively impair and partially invert neurovascular coupling (NVC) in the brain. Because cerebral and retinal microvasculature are governed by comparable regulatory mechanisms and may be connected by perivascular pathways, retinal vascular changes are increasingly recognized as a potential surrogate for altered NVC in the brain. Here, we used non-invasive retinal vessel analysis (RVA) to assess microvascular function in aSAH patients at different times after the ictus.},
  language  = {en}
}
@incollection{Kotliar2021,
  author    = {Kotliar, Konstantin},
  title     = {Ocular rigidity: clinical approach},
  series = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye},
  booktitle = {Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye},
  editor    = {Pallikaris, I. and Tsilimbaris, M. K. and Dastiridou, A. I.},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-030-64422-2},
  doi       = {10.1007/978-3-030-64422-2_2},
  pages     = {15 -- 43},
  year      = {2021},
  abstract  = {The term ocular rigidity is widely used in clinical ophthalmology. Generally it is assumed as a resistance of the whole eyeball to mechanical deformation and relates to biomechanical properties of the eye and its tissues. Basic principles and formulas for clinical tonometry, tonography and pulsatile ocular blood flow measurements are based on the concept of ocular rigidity. There is evidence for altered ocular rigidity in aging, in several eye diseases and after eye surgery. Unfortunately, there is no consensual view on ocular rigidity: it used to make a quite different sense for different people but still the same name. Foremost there is no clear consent between biomechanical engineers and ophthalmologists on the concept. Moreover ocular rigidity is occasionally characterized using various parameters with their different physical dimensions. In contrast to engineering approach, clinical approach to ocular rigidity claims to characterize the total mechanical response of the eyeball to its deformation without any detailed considerations on eye morphology or material properties of its tissues. Further to the previous chapter this section aims to describe clinical approach to ocular rigidity from the perspective of an engineer in an attempt to straighten out this concept, to show its advantages, disadvantages and various applications.},
  language  = {en}
}
@inproceedings{IomdinaKiselevaKotliaretal.2020,
  author    = {Iomdina, Elena N. and Kiseleva, Anna A. and Kotliar, Konstantin and Luzhnov, Petr V.},
  title     = {Quantification of Choroidal Blood Flow Using the OCT-A System Based on Voxel Scan Processing},
  series = {Proceedings of the International Conference on Biomedical Innovations and Applications- BIA 2020},
  booktitle = {Proceedings of the International Conference on Biomedical Innovations and Applications- BIA 2020},
  publisher = {IEEE},
  address   = {New York, NY},
  isbn      = {978-1-7281-7073-2},
  doi       = {10.1109/BIA50171.2020.9244511},
  pages     = {41 -- 44},
  year      = {2020},
  abstract  = {The paper presents a method for the quantitative assessment of choroidal blood flow using an OCT-A system. The developed technique for processing of OCT-A scans is divided into two stages. At the first stage, the identification of the boundaries in the selected portion was performed. At the second stage, each pixel mark on the selected layer was represented as a volume unit, a voxel, which characterizes the region of moving blood. Three geometric shapes were considered to represent the voxel. On the example of one OCT-A scan, this work presents a quantitative assessment of the blood flow index. A possible modification of two-stage algorithm based on voxel scan processing is presented.},
  language  = {en}
}
@article{WerfelGuenthnerHapfelmeieretal.2022,
  author    = {Werfel, Stanislas and G{\"u}nthner, Roman and Hapfelmeier, Alexander and Hanssen, Henner and Kotliar, Konstantin and Heemann, Uwe and Schmaderer, Christoph},
  title     = {Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning},
  series = {Cardiovascular Research},
  volume    = {118},
  journal   = {Cardiovascular Research},
  number    = {2},
  editor    = {Guzik, Tomasz J.},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {0008-6363},
  doi       = {10.1093/cvr/cvab040},
  pages     = {612 -- 621},
  year      = {2022},
  abstract  = {Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations.},
  language  = {en}
}
@article{MalanHamerKaeneletal.2020,
  author    = {Malan, Leone and Hamer, Mark and K{\"a}nel, Roland von and Kotliar, Konstantin and Wyk, Roelof D. van and Lambert, Gavin W. and Vilser, Walthard and Ziemssen, Tjalf and Schlaich, Markus P. and Smith, Wayne and Magnusson, Martin and Wentzel, Annemarie and Myburgh, Carlien E. and Steyn, Hendrik S. and Malan, Nico T.},
  title     = {Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study},
  series = {Cardiovascular Journal of Africa},
  volume    = {26},
  journal   = {Cardiovascular Journal of Africa},
  number    = {31},
  publisher = {Clinics Cardive Publishing},
  address   = {Durbanville},
  issn      = {1680-0745},
  doi       = {10.5830/CVJA-2020-031},
  pages     = {1 -- 12},
  year      = {2020},
  language  = {en}
}
@article{StreeseKotliarDeiserothetal.2020,
  author    = {Streese, Lukas and Kotliar, Konstantin and Deiseroth, Arne and Infanger, Denis and Gugleta, Konstantin and Schmaderer, Christoph and Hanssen, Henner},
  title     = {Retinal endothelial function in cardiovascular risk patients: A randomized controlled exercise trial},
  series = {Scandinavian Journal of Medicine and Science in Sports},
  volume    = {30},
  journal   = {Scandinavian Journal of Medicine and Science in Sports},
  number    = {2},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {1600-0838},
  doi       = {10.1111/sms.13560},
  pages     = {272 -- 280},
  year      = {2020},
  abstract  = {The aim of this study was to investigate, for the first time, the effects of high-intensity interval training (HIIT) on retinal microvascular endothelial function in cardiovascular (CV) risk patients. In the randomized controlled trial, middle-aged and previously sedentary patients with increased CV risk (aged 58 ± 6 years) with ≥ two CV risk factors were randomized into a 12-week HIIT (n = 33) or control group (CG, n = 36) with standard physical activity recommendations. A blinded examiner measured retinal endothelial function by flicker light-induced maximal arteriolar (ADmax) and venular (VDmax) dilatation as well as the area under the arteriolar (AFarea) and venular (VFarea) flicker curve using a retinal vessel analyzer. Standardized assessments of CV risk factors, cardiorespiratory fitness, and retinal endothelial function were performed before and after HIIT. HIIT reduced body mass index, fat mass, and low-density lipoprotein and increased muscle mass and peak oxygen uptake (VO2peak). Both ADmax (pre: 2.7 ± 2.1\%, post: 3.0 ± 2.2\%, P = .018) and AFarea (pre: 32.6 ± 28.4\%*s, post: 37.7 ± 30.6\%*s, P = .016) increased after HIIT compared with CG (ADmax, pre: 3.2 ± 1.8\%, post: 2.9 ± 1.8\%, P = .254; AFarea, pre: 41.6 ± 28.5\%*s, post: 37.8 ± 27.0\%*s, P = .186). Venular function remained unchanged after HIIT. There was a significant association between ∆-change VO2peak and ∆-changes ADmax and AFarea (P = .026, R² = 0.073; P = .019, R² = 0.081, respectively). 12-weeks of HIIT improved retinal endothelial function in middle-aged patients with increased CV risk independent of the reduction in classical CV risk factors. Exercise has the potential to reverse or at least postpone progression of small vessel disease in older adults with increased CV risk under standard medication. Dynamic retinal vessel analysis seems to be a sensitive tool to detect treatment effects of exercise interventions on retinal microvascular endothelial function in middle-aged individuals with increased CV risk.},
  language  = {en}
}
@article{HamouKotliarTanetal.2020,
  author    = {Hamou, Hussam Aldin and Kotliar, Konstantin and Tan, Sonny Kian and Weiß, Christel and Blume, Christian and Clusmann, Hans and Schubert, Gerrit Alexander and Albanna, Walid},
  title     = {Surgical nuances and placement of subgaleal drains for supratentorial procedures—a prospective analysis of efficacy and outcome in 150 craniotomies},
  series = {Acta Neurochirurgica},
  volume    = {2020},
  journal   = {Acta Neurochirurgica},
  number    = {162},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {0942-0940},
  doi       = {10.1007/s00701-019-04196-6},
  pages     = {729 -- 736},
  year      = {2020},
  abstract  = {Background For supratentorial craniotomy, surgical access, and closure technique, including placement of subgaleal drains, may vary considerably. The influence of surgical nuances on postoperative complications such as cerebrospinal fluid leakage or impaired wound healing overall remains largely unclear. With this study, we are reporting our experiences and the impact of our clinical routines on outcome in a prospectively collected data set. Method We prospectively observed 150 consecutive patients undergoing supratentorial craniotomy and recorded technical variables (type/length of incision, size of craniotomy, technique of dural and skin closure, type of dressing, and placement of subgaleal drains). Outcome variables (subgaleal hematoma/CSF collection, periorbital edema, impairment of wound healing, infection, and need for operative revision) were recorded at time of discharge and at late follow-up. Results Early subgaleal fluid collection was observed in 36.7\% (2.8\% at the late follow-up), and impaired wound healing was recorded in 3.3\% of all cases, with an overall need for operative revision of 6.7\%. Neither usage of dural sealants, lack of watertight dural closure, and presence of subgaleal drains, nor type of skin closure or dressing influenced outcome. Curved incisions, larger craniotomy, and tumor size, however, were associated with an increase in early CSF or hematoma collection (p < 0.0001, p = 0.001, p < 0.01 resp.), and larger craniotomy size was associated with longer persistence of subgaleal fluid collections (p < 0.05). Conclusions Based on our setting, individual surgical nuances such as the type of dural closure and the use of subgaleal drains resulted in a comparable complication rate and outcome. Subgaleal fluid collections were frequently observed after supratentorial procedures, irrespective of the closing technique employed, and resolve spontaneously in the majority of cases without significant sequelae. Our results are limited due to the observational nature in our single-center study and need to be validated by supportive prospective randomized design.},
  language  = {en}
}
@article{RamoshabaHuismanLammertynetal.2020,
  author    = {Ramoshaba, Nthai E. and Huisman, Hugo W. and Lammertyn, Leandi and Kotliar, Konstantin and Schutte, Aletta E. and Smith, Wayne},
  title     = {Retinal microvasculature and masked hypertension in young adults: the African-PREDICT study},
  series = {Hypertension Research},
  journal   = {Hypertension Research},
  number    = {43},
  publisher = {Springer Nature},
  address   = {Osaka},
  issn      = {1348-4214},
  doi       = {10.1038/s41440-020-0487-0},
  pages     = {1231 -- 1238},
  year      = {2020},
  abstract  = {Masked hypertension is known to induce microvascular complications. However, it is unclear whether early microvascular changes are already occurring in young, otherwise healthy adults. We therefore investigated whether retinal microvascular calibers and acute responses to a flicker stimulus are related to masked hypertension. We used the baseline data of 889 participants aged 20-30 years who were taking part in the African Prospective study on the Early Detection and Identification of Cardiovascular Disease and Hypertension. Clinic and 24-h ambulatory blood pressure were measured. The central retinal artery equivalent (CRAE) and central retinal vein equivalent were calculated from fundus images, and retinal vessel dilation was determined in response to flicker light-induced provocation. A smaller CRAE was observed in those with masked hypertension vs. those with normotension (157.1 vs. 161.2 measuring units, P < 0.001). In forward multivariable-adjusted regression analysis, only CRAE was negatively related to masked hypertension [adjusted R² = 0.267, β = -0.097 (95\% CI = -0.165; -0.029), P = 0.005], but other retinal microvascular parameters were not associated with masked hypertension. In multivariable logistic regression analyses, masked hypertension [OR = 2.333, (95\% CI = 1.316; 4.241), P = 0.004] was associated with a narrower CRAE. In young healthy adults, masked hypertension was associated with retinal arteriolar narrowing, thereby reflecting early microvascular alterations known to predict cardiovascular outcomes in later life.},
  language  = {en}
}
@article{SmithKotliarLammertynetal.2020,
  author    = {Smith, Wayne and Kotliar, Konstantin and Lammertyn, Leandi and Ramoshaba, Nthai E. and Vilser, Walthard and Huisman, Hugo W. and Schutte, Aletta E.},
  title     = {Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study},
  series = {Microvascular Research},
  volume    = {128},
  journal   = {Microvascular Research},
  number    = {Article 103937},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0026-2862},
  doi       = {10.1016/j.mvr.2019.103937},
  year      = {2020},
  abstract  = {Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults. Methods We included 112 black and 143 white healthy normotensive adults (20-30 years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected. Results The groups displayed similar 24 h BP profiles and anthropometry (all p > .24). Black participants demonstrated a smaller CRAE (158 ± 11 vs. 164 ± 11 MU, p < .001) compared to the white group, whereas CRVE was similar (p = .57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6 ± 2.1 vs. 3.3 ± 1.8\%; p < .001). Conclusions Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation.},
  language  = {en}
}
@article{FissabreRottke2023,
  author    = {Fissabre, Anke and Rottke, Evelin},
  title     = {Das Quelle-Fertighaus : Einklang von Maß, Konstruktion und Entwurf},
  series = {architectura},
  volume    = {51},
  journal   = {architectura},
  number    = {1},
  editor    = {Bergdoll, Barry and Schwarting, Andreas and Tragbar, Klaus},
  publisher = {Deutscher Kunstverlag (DKV)},
  address   = {Berlin},
  issn      = {2569-1554},
  doi       = {10.1515/atc-2021-1005},
  pages     = {57 -- 78},
  year      = {2023},
  abstract  = {The steel prefabricated family house ›Quelle-Fertighaus‹ designed and constructed by the German company Quelle, is an innovative modular system commercialised in 1962. All aspects of the Quelle-Fertighaus are planned on the principle of minimal effort for maximal flexibility. The clever design of the ground plan based on a 4 m × 7 m module offers the flexibility for either one to three additional modules. The steel construction is innovative and unique, consisting of load-bearing portal frames acting as braces. The house design is furthermore characterised by a simple metrical grid layout and the practical placement of the foundation and basement, which allowed the very cost-effective production and the lowest price for a prefabricated family house in Germany during the postwar era. Nowadays its portal-frame-construction offers an interesting approach for its renovation and transformation according to present building demands.},
  language  = {de}
}
@article{NeumaierKotliarHaerenetal.2021,
  author    = {Neumaier, Felix and Kotliar, Konstantin and Haeren, Roel Hubert Louis and Temel, Yasin and L{\"u}ke, Jan Niklas and Seyam, Osama and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Schubert, Gerrit Alexander and Schneider, Toni and Albanna, Walid},
  title     = {Retinal Vessel Responses to Flicker Stimulation Are Impaired in Ca v 2.3-Deficient Mice—An in- vivo Evaluation Using Retinal Vessel Analysis (RVA)},
  series = {Frontiers in Neurology},
  volume    = {12},
  journal   = {Frontiers in Neurology},
  publisher = {Frontiers},
  doi       = {10.3389/fneur.2021.659890},
  pages     = {1 -- 11},
  year      = {2021},
  language  = {en}
}
@inproceedings{HauggKreyerKemperetal.2020,
  author    = {Haugg, Albert Thomas and Kreyer, J{\"o}rg and Kemper, Hans and Hatesuer, Katerina and Esch, Thomas},
  title     = {Heat exchanger for ORC. adaptability and optimisation potentials},
  series = {IIR International Rankine 2020 Conference},
  booktitle = {IIR International Rankine 2020 Conference},
  doi       = {10.18462/iir.rankine.2020.1224},
  pages     = {10 Seiten},
  year      = {2020},
  abstract  = {The recovery of waste heat requires heat exchangers to extract it from a liquid or gaseous medium into another working medium, a refrigerant. In Organic Rankine Cycles (ORC) on Combustion Engines there are two major heat sources, the exhaust gas and the water/glycol fluid from the engine's cooling circuit. A heat exchanger design must be adapted to the different requirements and conditions resulting from the heat sources, fluids, system configurations, geometric restrictions, and etcetera. The Stacked Shell Cooler (SSC) is a new and very specific design of a plate heat exchanger, created by AKG, which allows with a maximum degree of freedom the optimization of heat exchange rate and the reduction of the related pressure drop. This optimization in heat exchanger design for ORC systems is even more important, because it reduces the energy consumption of the system and therefore maximizes the increase in overall efficiency of the engine.},
  language  = {en}
}
@incollection{AtmaneHirechKassmietal.2020,
  author    = {Atmane, Ilias and Hirech, Kamal and Kassmi, K. and Mahdi, Zahra and Alexopoulos, Spiros and Schwarzer, Klemens and Chayeb, H. and Bachiri, N.},
  title     = {Design and realization of a pilot solar desalination plant in Douar El Hamri in the province of Berkane (Morocco)},
  series = {Sustainable entrepreneurship, renewable energy-based projects, and digitalization},
  booktitle = {Sustainable entrepreneurship, renewable energy-based projects, and digitalization},
  editor    = {Omrane, Amina and Kassmi, Khalil and Akram, Muhammad Wasim and Khanna, Ashish and Mostafiz, Imtiaz},
  publisher = {CRC Press},
  address   = {Boca Raton, Fa.},
  isbn      = {9781000292541 (E-Book)},
  pages     = {18 Seiten},
  year      = {2020},
  abstract  = {Producing fresh water from saline water has become one of the most difficult challenges to overcome especially with the high demand and shortage of fresh water. In this context, as part of a collaboration with Germany, the authors propose a design and implementation of a pilot multi-stage solar desalination system (MSD), remotely controlled, at Douar Al Hamri in the rural town of Boughriba in the province of Berkane, Morocco. More specifically, they present their contribution on the remote control and supervision system, which makes the functioning of the MSD system reliable and guarantees the production of drinking water for the population of Douar. The results obtained show that the electronic cards and computer communication software implemented allow the acquisition of all electrical (currents, voltages, powers, yields), thermal (temperatures of each stage), and meteorological (irradiance and ambient temperature), remote control and maintenance (switching on, off, data transfer). By comparing with the literature carried out in the field of solar energy, the authors conclude that the MSD and electronic desalination systems realized during this work represent a contribution in terms of the reliability and durability of providing drinking water in rural and urban areas.},
  language  = {en}
}
@inproceedings{AlexopoulosBreitbachHoffschmidt2009,
  author    = {Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard},
  title     = {Optimization of the channel form geometry of porous ReSiC ceramic membrane modules},
  series = {Proceedings / International Conference \& Exhibition for Filtration and Separation Technology, FILTECH 2009 : October 13 - 15, 2009, Wiesbaden, Germany. Vol. 2},
  booktitle = {Proceedings / International Conference \& Exhibition for Filtration and Separation Technology, FILTECH 2009 : October 13 - 15, 2009, Wiesbaden, Germany. Vol. 2},
  publisher = {Filtech Exhibitions Germany},
  address   = {Meerbusch},
  isbn      = {978-3-941655-36-2},
  pages     = {686 -- 693},
  year      = {2009},
  language  = {en}
}
@article{DegeringEggertPulsetal.2010,
  author    = {Degering, Christian and Eggert, Thorsten and Puls, Michael and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and Jaeger, Karl-Erich},
  title     = {Optimization of protease secretion in Bacillus subtilis and Bacillus licheniformis by screening of homologous and herologous signal peptides},
  series = {Applied and environmental microbiology},
  volume    = {76},
  journal   = {Applied and environmental microbiology},
  number    = {19},
  publisher = {American Society for Microbiology},
  address   = {Washington, DC},
  issn      = {1098-5336 (E-Journal); 0003-6919 (Print); 0099-2240 (Print)},
  doi       = {10.1128/AEM.01146-10},
  pages     = {6370 -- 6378},
  year      = {2010},
  abstract  = {Bacillus subtilis and Bacillus licheniformis are widely used for the large-scale industrial production of proteins. These strains can efficiently secrete proteins into the culture medium using the general secretion (Sec) pathway. A characteristic feature of all secreted proteins is their N-terminal signal peptides, which are recognized by the secretion machinery. Here, we have studied the production of an industrially important secreted protease, namely, subtilisin BPN′ from Bacillus amyloliquefaciens. One hundred seventy-three signal peptides originating from B. subtilis and 220 signal peptides from the B. licheniformis type strain were fused to this secretion target and expressed in B. subtilis, and the resulting library was analyzed by high-throughput screening for extracellular proteolytic activity. We have identified a number of signal peptides originating from both organisms which produced significantly increased yield of the secreted protease. Interestingly, we observed that levels of extracellular protease were improved not only in B. subtilis, which was used as the screening host, but also in two different B. licheniformis strains. To date, it is impossible to predict which signal peptide will result in better secretion and thus an improved yield of a given extracellular target protein. Our data show that screening a library consisting of homologous and heterologous signal peptides fused to a target protein can identify more-effective signal peptides, resulting in improved protein export not only in the original screening host but also in different production strains.},
  language  = {en}
}
@article{DeppeBongaertsO'Connelletal.2011,
  author    = {Deppe, Veronika Maria and Bongaerts, Johannes and O'Connell, Timothy and Maurer, Karl-Heinz and Meinhardt, Friedhelm},
  title     = {Enzymatic deglycation of Amadori products in bacteria},
  series = {Applied microbiology and biotechnology},
  volume    = {Vol. 90},
  journal   = {Applied microbiology and biotechnology},
  number    = {Iss. 2},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)},
  pages     = {399 -- 406},
  year      = {2011},
  language  = {en}
}
@inproceedings{IlleSchrammAdametal.2009,
  author    = {Ille, Fabian and Schramm, S. and Adam, M. and Backes, K. and Anthrakidis, Anette and Faber, Christian},
  title     = {Kraft-W{\"a}rme-K{\"a}lte-Kopplung im Leistungsbereich in 10kW mit periodisch arbeitender Sorptionsmaschine},
  series = {DKV-Tagungsbericht. 35,2,1. Deutsche K{\"a}lte-Klima-Tagung 2008 Ulm},
  booktitle = {DKV-Tagungsbericht. 35,2,1. Deutsche K{\"a}lte-Klima-Tagung 2008 Ulm},
  publisher = {Dt. K{\"a}lte- und Klimatechnischer Verein},
  address   = {Hannover},
  isbn      = {978-3-932715-44-0},
  pages     = {305 -- 320},
  year      = {2009},
  language  = {de}
}
@inproceedings{AhlbrinkAlexopoulosAnderssonetal.2009,
  author    = {Ahlbrink, N. and Alexopoulos, Spiros and Andersson, J. and Belhomme, B. and Teixeira Boura, Cristiano Jos{\´e} and Gall, J. and Hirsch, T.},
  title     = {viCERP - the Virtual Institute of Central Receiver Power Plant},
  series = {MATHMOD 2009 - 6th Vienna International Conference on Mathematical Modelling : February 11 - 13, 2009, Vienna, Austria. ARGESIM Report. No. 35},
  booktitle = {MATHMOD 2009 - 6th Vienna International Conference on Mathematical Modelling : February 11 - 13, 2009, Vienna, Austria. ARGESIM Report. No. 35},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {978-3-901608-35-3},
  year      = {2009},
  language  = {en}
}
@article{AlexopoulosHoffschmidt2017,
  author    = {Alexopoulos, Spiros and Hoffschmidt, Bernhard},
  title     = {Advances in solar tower technology},
  series = {Wiley interdisciplinary reviews : Energy and Environment : WIREs},
  volume    = {6},
  journal   = {Wiley interdisciplinary reviews : Energy and Environment : WIREs},
  number    = {1},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {2041-840X},
  doi       = {10.1002/wene.217},
  pages     = {1 -- 19},
  year      = {2017},
  language  = {en}
}