@article{BassamHeschelerTemizArtmannetal.2012,
  author    = {Bassam, Rasha and Hescheler, J{\"u}rgen and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard and Digel, Ilya},
  title     = {Effects of spermine NONOate and ATP on the thermal stability of hemoglobin},
  series = {BMC Biophysics},
  volume    = {5},
  journal   = {BMC Biophysics},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {2046-1682},
  doi       = {10.1186/2046-1682-5-16},
  pages     = {Art. 16},
  year      = {2012},
  abstract  = {Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell.},
  language  = {en}
}
@article{MansurovDigelBiisenbaevetal.2012,
  author    = {Mansurov, Z. and Digel, Ilya and Biisenbaev, M. and Savistkaya, I. and Kistaubaeva, A. and Akimbekov, Nuraly S. and Zhubanova, A.},
  title     = {Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications},
  series = {Eurasian Chemico-Technological Journal},
  volume    = {14},
  journal   = {Eurasian Chemico-Technological Journal},
  number    = {2},
  publisher = {Institute of Combustion Problems},
  address   = {Almaty},
  issn      = {2522-4867},
  doi       = {10.18321/ectj105},
  pages     = {115 -- 131},
  year      = {2012},
  language  = {en}
}
@article{GorissenStaatLaack2012,
  author    = {Gorissen, P. and Staat, Manfred and Laack, Walter van},
  title     = {Experimentelle Kraftmessungen als Beitrag zur Wirksamkeitsbeurteilung von Schienbeinschonern im Fußballsport},
  series = {OUP Zeitschrift f{\"u}r die orthop{\"a}dische und unfallchirurgische Praxis},
  volume    = {1},
  journal   = {OUP Zeitschrift f{\"u}r die orthop{\"a}dische und unfallchirurgische Praxis},
  number    = {1},
  publisher = {Deutscher {\"A}rzte-Verlag},
  address   = {K{\"o}ln},
  issn      = {2193-5785},
  doi       = {10.3238/oup.2012.0010-0015},
  pages     = {10 -- 15},
  year      = {2012},
  abstract  = {Diese Studie besch{\"a}ftigte sich mit der D{\"a}mpfungswirkung von Schienbeinschonern, wie sie beim Fußball zum Einsatz kommen. Sie wurde mit Hilfe eines Pendelhammers durchgef{\"u}hrt, der verschiedene Aufschlagkr{\"a}fte auf die Schoner erm{\"o}glichte. Dabei wurde deutlich, dass Schienbeinschoner die beste Wirkung bei Maximalkr{\"a}ften unterhalb von 5kN erreichen k{\"o}nnen, dass bei gr{\"o}ßerer Belastung allerdings Verbesserungsbedarf besteht. Hierf{\"u}r konnte, u.a. durch den Einsatz neuer Materialien, ein guter Ansatzpunkt im „ad{\"a}quaten Zusammenspiel von Schale und Polsterung" der Schoner gefunden werden. Die Untersuchung hat weiterhin gezeigt, dass zumindest teilweise eine deutliche Verbesserung der D{\"a}mpfungswirkung der Schienbeinschoner in den letzten Jahren erreicht werden konnte.},
  subject      = {Fußball},
  language  = {de}
}
@article{Wilke2012,
  author    = {Wilke, Thomas},
  title     = {Architekturzeichnung als Instrument der Theoriebildung. Lineamenta vs. Portraicture - Architekturdarstellung zwischen Wissenschaft und {\"O}ffentlichkeit. Tagung des DFG-Netzwerks-Schnittstelle Bild in Zusammenarbeit mit dem Lehrstuhl f{\"u}r Kunstgeschichte der Universit{\"a}t Regensburg, 28.4.2012.},
  series = {Kunstchronik},
  volume    = {65},
  journal   = {Kunstchronik},
  number    = {9/10},
  publisher = {Fachverlag Hans Carl},
  address   = {N{\"u}rnberg},
  issn      = {0023-5474},
  pages     = {494 -- 499},
  year      = {2012},
  language  = {de}
}
@article{ScheerKapelyukhMcEwanetal.2012,
  author    = {Scheer, Nico and Kapelyukh, Yury and McEwan, Jillian and Beuger, Vincent and Stanley, Lesley A. and Rode, Anja and Wolf, C. Roland},
  title     = {Modeling Human Cytochrome P450 2D6 Metabolism and Drug-drug Interaction by a Novel Panel of Knockout and Humanized Mouse Lines},
  series = {Molecular Pharmacology},
  volume    = {81},
  journal   = {Molecular Pharmacology},
  number    = {1},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.111.075192},
  pages     = {63 -- 72},
  year      = {2012},
  abstract  = {The highly polymorphic human cytochrome P450 2D6 enzyme is involved in the metabolism of up to 25\% of all marketed drugs and accounts for significant individual differences in response to CYP2D6 substrates. Because of the differences in the multiplicity and substrate specificity of CYP2D family members among species, it is difficult to predict pathways of human CYP2D6-dependent drug metabolism on the basis of animal studies. To create animal models that reflect the human situation more closely and that allow an in vivo assessment of the consequences of differential CYP2D6 drug metabolism, we have developed a novel straightforward approach to delete the entire murine Cyp2d gene cluster and replace it with allelic variants of human CYP2D6. By using this approach, we have generated mouse lines expressing the two frequent human protein isoforms CYP2D6.1 and CYP2D6.2 and an as yet undescribed variant of this enzyme, as well as a Cyp2d cluster knockout mouse. We demonstrate that the various transgenic mouse lines cover a wide spectrum of different human CYP2D6 metabolizer phenotypes. The novel humanization strategy described here provides a robust approach for the expression of different CYP2D6 allelic variants in transgenic mice and thus can help to evaluate potential CYP2D6-dependent interindividual differences in drug response in the context of personalized medicine.},
  language  = {en}
}
@article{PaulssenKongArciszewskietal.2012,
  author    = {Paulßen, Elisabeth and Kong, Shushu and Arciszewski, Pawel and Wielbalck, Swantje and Abram, Ulrich},
  title     = {Aryl and NHC Compounds of Technetium and Rhenium},
  series = {Journal of the American Chemical Society},
  volume    = {134},
  journal   = {Journal of the American Chemical Society},
  number    = {22},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {1520-5126},
  doi       = {10.1021/ja3033718},
  pages     = {9118 -- 9121},
  year      = {2012},
  abstract  = {Air- and water-stable phenyl complexes with nitridotechnetium(V) cores can be prepared by straightforward procedures. [TcNPh2(PPh3)2] is formed by the reaction of [TcNCl2(PPh3)2] with PhLi. The analogous N-heterocyclic carbene (NHC) compound [TcNPh2(HLPh)2], where HLPh is 1,3,4-triphenyl-1,2,4-triazol-5-ylidene, is available from (NBu4)[TcNCl4] and HLPh or its methoxo-protected form. The latter compound allows the comparison of different Tc-C bonds within one compound. Surprisingly, the Tc chemistry with such NHCs does not resemble that of corresponding Re complexes, where CH activation and orthometalation dominate.},
  language  = {en}
}
@article{PaulssenNgyugenKahlckeetal.2012,
  author    = {Paulßen, Elisabeth and Ngyugen, Hung Huy and Kahlcke, Nils and Deflon, Victor M. and Abram, Ulrich},
  title     = {Tricarbonyltechnetium(I) and -rhenium(I) complexes with N′-thiocarbamoylpicolylbenzamidines},
  series = {Polyhedron},
  volume    = {40},
  journal   = {Polyhedron},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0277-5387},
  doi       = {10.1016/j.poly.2012.04.008},
  pages     = {153 -- 158},
  year      = {2012},
  abstract  = {N,N-Dialkylamino(thiocarbonyl)-N′-picolylbenzamidines react with (NEt4)2[M(CO)3X3] (M = Re, X = Br; M = Tc, X = Cl) under formation of neutral [M(CO)3L] complexes in high yields. The monoanionic NNS ligands bind in a facial coordination mode and can readily be modified at the (CS)NR1R2 moiety. The complexes [99Tc(CO)3(LPyMor)] and [Re(CO)3(L)] (L = LPyMor, LPyEt) were characterized by X-ray diffraction. Reactions of [99mTc(CO)3(H2O)3]+ with the N′-thiocarbamoylpicolylbenzamidines give the corresponding 99mTc complexes. The ester group in HLPyCOOEt allows linkage between biomolecules and the metal core.},
  language  = {en}
}
@article{CzarneckiSpiliopoulou2012,
  author    = {Czarnecki, Christian and Spiliopoulou, Myra},
  title     = {A holistic framework for the implementation of a next generation network},
  series = {International Journal of Business Information Systems},
  volume    = {9},
  journal   = {International Journal of Business Information Systems},
  number    = {4},
  publisher = {Inderscience Enterprises},
  address   = {Olney, Bucks},
  issn      = {1746-0972},
  doi       = {10.1504/IJBIS.2012.046291},
  pages     = {385 -- 401},
  year      = {2012},
  abstract  = {As the potential of a next generation network (NGN) is recognised, telecommunication companies consider switching to it. Although the implementation of an NGN seems to be merely a modification of the network infrastructure, it may trigger or require changes in the whole company, because it builds upon the separation between service and transport, a flexible bundling of services to products and the streamlining of the IT infrastructure. We propose a holistic framework, structured into the layers 'strategy', 'processes' and 'information systems' and incorporate into each layer all concepts necessary for the implementation of an NGN, as well as the alignment of these concepts. As a first proof-of-concept for our framework we have performed a case study on the introduction of NGN in a large telecommunication company; we show that our framework captures all topics that are affected by an NGN implementation.},
  language  = {en}
}
@article{Olbertz2012,
  author    = {Olbertz, Klaus},
  title     = {{\"U}bergang von Leiharbeitnehmern bei {\"U}bertragung des Entleiherbetriebs - Entscheidung des EuGH zum Recht des Betriebs{\"u}bergangs},
  series = {NWB - Steuer- und Wirtschaftsrecht},
  journal   = {NWB - Steuer- und Wirtschaftsrecht},
  number    = {5},
  publisher = {NWB-Verlag},
  address   = {Herne},
  issn      = {1860-9449},
  pages     = {398 -- 403},
  year      = {2012},
  abstract  = {Wieder einmal hat eine Entscheidung des Europ{\"a}ischen Gerichtshofs (EuGH) das bisherige nationale Verst{\"a}ndnis zu einer Frage des Rechts des Betriebs{\"u}bergangs erheblich ins Wanken gebracht. Bisher entsprach es allgemeiner Auffassung, dass die Arbeitsverh{\"a}ltnisse von Zeit- bzw. Leiharbeitnehmern bei einem Betriebs(teil){\"u}bergang des die Leiharbeitnehmer entleihenden Betriebs nicht auf den Betriebserwerber {\"u}bergehen. Der EuGH hat in der Rechtssache Albron Catering mit Urteil vom 21.10.2010 jedoch entschieden, dass auch Leiharbeitnehmer von einem Betriebs(teil){\"u}bergang erfasst sein k{\"o}nnen. Folglich kann der Erwerber eines Betriebs oder Betriebsteils gem. \S 613a BGB zuk{\"u}nftig verpflichtet sein, auch die an den Betriebsver{\"a}ußerer verliehenen Leiharbeitnehmer zu {\"u}bernehmen. Die Entscheidung des EuGH hat somit zur Konsequenz, dass der {\"U}bergang von Leiharbeitsverh{\"a}ltnissen auf den Erwerber eines Betriebs jedenfalls nicht mehr pauschal ausgeschlossen werden kann. Dies gilt es bei k{\"u}nftigen Betriebs(teil){\"u}bertragungen zu ber{\"u}cksichtigen, um unliebsame {\"U}berraschungen zu vermeiden.},
  language  = {de}
}
@article{OlbertzFahrig2012,
  author    = {Olbertz, Klaus and Fahrig, Stephan},
  title     = {Offshoring als Betriebs(teil){\"u}bergang gem{\"a}ß \S 613a BGB},
  series = {ZIP Zeitschrift f{\"u}r Wirtschaftsrecht},
  journal   = {ZIP Zeitschrift f{\"u}r Wirtschaftsrecht},
  number    = {42},
  publisher = {Verlag Dr. Otto Schmidt},
  address   = {K{\"o}ln},
  issn      = {0723-9416},
  pages     = {2045},
  year      = {2012},
  language  = {de}
}
@article{OrzadaMaderwaldPoseretal.2012,
  author    = {Orzada, S. and Maderwald, S. and Poser, B. A. and Johst, S. and Kannengiesser, S. and Ladd, M. E. and Bitz, Andreas},
  title     = {Time-interleaved acquisition of modes: an analysis of SAR and image contrast implications},
  series = {Magnetic Resonance in Medicine},
  volume    = {67},
  journal   = {Magnetic Resonance in Medicine},
  number    = {4},
  publisher = {Wiley-Liss},
  address   = {New York},
  issn      = {1522-2594},
  doi       = {10.1002/mrm.23081},
  pages     = {1033 -- 1041},
  year      = {2012},
  abstract  = {s the magnetic field strength and therefore the operational frequency in MRI are increased, the radiofrequency wavelength approaches the size of the human head/body, resulting in wave effects which cause signal decreases and dropouts. Especially, whole-body imaging at 7 T and higher is therefore challenging. Recently, an acquisition scheme called time-interleaved acquisition of modes has been proposed to tackle the inhomogeneity problems in high-field MRI. The basic premise is to excite two (or more) different Burn:x-wiley:07403194:media:MRM23081:tex2gif-stack-1 modes using static radiofrequency shimming in an interleaved acquisition, where the complementary radiofrequency patterns of the two modes can be exploited to improve overall signal homogeneity. In this work, the impact of time-interleaved acquisition of mode on image contrast as well as on time-averaged specific absorption rate is addressed in detail. Time-interleaved acquisition of mode is superior in Burn:x-wiley:07403194:media:MRM23081:tex2gif-stack-2 homogeneity compared with conventional radiofrequency shimming while being highly specific absorption rate efficient. Time-interleaved acquisition of modes can enable almost homogeneous high-field imaging throughout the entire field of view in PD, T2, and T2*-weighted imaging and, if a specified homogeneity criterion is met, in T1-weighted imaging as well.},
  language  = {en}
}
@article{KobusBitzUdenetal.2012,
  author    = {Kobus, Thiele and Bitz, Andreas and Uden, Mark J. van and Lagemaat, Miram W. and Rothgang, Eva and Orzada, Stephan and Heerschap, Arend and Scheenen, Tom W. J.},
  title     = {In vivo 31P MR spectroscopic imaging of the human prostate at 7 T: safety and feasibility},
  series = {Magnetic Resonance in Medicine},
  volume    = {68},
  journal   = {Magnetic Resonance in Medicine},
  number    = {6},
  publisher = {Wiley-Liss},
  address   = {New York},
  issn      = {1522-2594},
  doi       = {10.1002/mrm.24175},
  pages     = {1683 -- 1695},
  year      = {2012},
  abstract  = {31P MR spectroscopic imaging of the human prostate provides information about phosphorylated metabolites that could be used for prostate cancer characterization. The sensitivity of a magnetic field strength of 7 T might enable 3D 31P MR spectroscopic imaging with relevant spatial resolution in a clinically acceptable measurement time. To this end, a 31P endorectal coil was developed and combined with an eight-channel 1H body-array coil to relate metabolic information to anatomical location. An extensive safety validation was performed to evaluate the specific absorption rate, the radiofrequency field distribution, and the temperature distribution of both coils. This validation consisted of detailed Finite Integration Technique simulations, confirmed by MR thermometry and Burn:x-wiley:07403194:media:MRM24175:tex2gif-stack-1 measurements in a phantom and in vivo temperature measurements. The safety studies demonstrated that the presence of the 31P endorectal coil had no influence on the specific absorption rate levels and temperature distribution of the external eight-channel 1H array coil. To stay within a 10 g averaged local specific absorption rate of 10 W/kg, a maximum time-averaged input power of 33 W for the 1H array coil was allowed. For transmitting with the 31P endorectal coil, our safety limit of less than 1°C temperature increase in vivo during a 15-min MR spectroscopic imaging experiment was reached at a time-averaged input power of 1.9 W. With this power setting, a second in vivo measurement was performed on a healthy volunteer. Using adiabatic excitation, 3D 31P MR spectroscopic imaging produced spectra from the entire prostate in 18 min with a spatial resolution of 4 cm3. The spectral resolution enabled the separate detection of phosphocholine, phosphoethanolamine, inorganic phosphate, and other metabolites that could play an important role in the characterization of prostate cancer.},
  language  = {en}
}
@article{YazdanbakhshSolbachBitz2012,
  author    = {Yazdanbakhsh, Pedram and Solbach, Klaus and Bitz, Andreas},
  title     = {Variable power combiner for RF mode shimming in 7-T MR imaging},
  series = {IEEE Transaction on Biomedical Engineering},
  volume    = {59},
  journal   = {IEEE Transaction on Biomedical Engineering},
  number    = {9},
  publisher = {IEEE},
  address   = {New York},
  issn      = {1558-2531},
  doi       = {10.1109/TBME.2012.2205926},
  pages     = {2549 -- 2557},
  year      = {2012},
  abstract  = {This contribution discusses the utilization of RF power in an MRI system with RF mode shimming which enables the superposition of circularly polarized modes of a transmit RF coil array driven by a Butler matrix. Since the required power for the individual modes can vary widely, mode-shimming can result in a significant underutilization of the total available RF power. A variable power combiner (VPC) is proposed to improve the power utilization: it can be realized as a reconfiguration of the MRI transmit system by the inclusion of one additional matrix network which receives the power from all transmit amplifiers at its input ports and provides any desired (combined) power distribution at its output ports by controlling the phase and amplitude of the amplifiers' input signals. The power distribution at the output ports of the VPC is then fed into the "mode" ports of the coil array Butler matrix in order to superimpose the spatial modes at the highest achievable power utilization. The VPC configuration is compared to the standard configuration of the transmit chain of our MRI system with 8 transmit channels and 16 coils. In realistic scenarios, improved power utilization was achieved from 17\% to 60\% and from 14\% to 55\% for an elliptical phantom and a region of interest in the abdomen, respectively, and an increase of the power utilization of 1 dB for a region of interest in the upper leg. In general, it is found that the VPC allows significant improvement in power utilization when the shimming solution demands only a few modes to be energized, while the technique can yield loss in power utilization in cases with many modes required at high power level.},
  language  = {en}
}
@article{KrollLudwigs2012,
  author    = {Kroll-Ludwigs, Kathrin},
  title     = {Ein optionales Vertragsrecht f{\"u}r Europa: Motor oder Hemmnis f{\"u}r den Binnenmarkt?},
  series = {GPR : Zeitschrift f{\"u}r Gemeinschaftsprivatrecht},
  volume    = {9},
  journal   = {GPR : Zeitschrift f{\"u}r Gemeinschaftsprivatrecht},
  number    = {4},
  publisher = {Verlag Dr. Otto Schmidt},
  address   = {K{\"o}ln},
  issn      = {2193-9519},
  doi       = {10.1515/gpr.2012.9.4.181},
  pages     = {181 -- 188},
  year      = {2012},
  language  = {de}
}
@article{ChludekTran2012,
  author    = {Chludek, Astrid and Tran, Duc Hung},
  title     = {Der Reformvorschlag des IAS 12 gem. ED/2009/2 - Ein Pl{\"a}doyer f{\"u}r die Einf{\"u}hrung der valuation allowance},
  series = {KoR Zeitschrift f{\"u}r kapitalmarktorientierte Rechnungslegung},
  journal   = {KoR Zeitschrift f{\"u}r kapitalmarktorientierte Rechnungslegung},
  number    = {1},
  publisher = {Fachmedien Otto Schmidt},
  address   = {D{\"u}sseldorf},
  issn      = {1617-8084},
  pages     = {4 -- 8},
  year      = {2012},
  language  = {de}
}
@article{HerzwurmKramsPietschetal.2012,
  author    = {Herzwurm, Georg and Krams, Benedikt and Pietsch, Wolfram and Schockert, Sixten},
  title     = {Report from the 3rd international workshop on requirements prioritization for customer oriented software development (RePriCo'12)},
  series = {ACM SIGSOFT Software Engineering Notes},
  volume    = {37},
  journal   = {ACM SIGSOFT Software Engineering Notes},
  number    = {4},
  publisher = {Association for Computing Machinery},
  address   = {New York},
  issn      = {0163-5948},
  doi       = {10.1145/2237796.2237817},
  pages     = {32 -- 34},
  year      = {2012},
  abstract  = {Prioritization is an essential task within requirements engineering to cope with complexity and to establish focus properly. The 3rd Workshop on Requirements Prioritization for customer oriented Software Development (RePriCo'12) focused on requirements prioritization and adjacent themes in the context of customer oriented development of bespoke and standard software. Five submissions have been accepted for the proceedings and for presentation. The report summarizes and points out key findings.},
  language  = {en}
}
@article{Alexopoulos2012,
  author    = {Alexopoulos, Spiros},
  title     = {Biogas systems: basics, biogas multifunction, principle of fermentation and hybrid application with a solar tower for the treatment of waste animal manure},
  series = {Journal of Engineering Science and Technology Review},
  volume    = {5},
  journal   = {Journal of Engineering Science and Technology Review},
  number    = {4},
  issn      = {1791-2377},
  pages     = {48 -- 55},
  year      = {2012},
  abstract  = {Two of the main environmental problems of today's society are the continuously increasing production of organic wastes as well as the increase of carbon dioxide in the atmosphere and the related green house effect. A way to solve these problems is the production of biogas. Biogas is a combustible gas consisting of methane, carbon dioxide and small amounts of other gases and trace elements. Production of biogas through anaerobic digestion of animal manure and slurries as well as of a wide range of digestible organic wastes and agricultural residues, converts these substrates into electricity and heat and offers a natural fertiliser for agriculture. The microbiological process of decomposition of organic matter, in the absence of oxygen takes place in reactors, called digesters. Biogas can be used as a fuel in a gas turbine or burner and can be used in a hybrid solar tower system offering a solution for waste treatment of agricultural and animal residues. A solar tower system consists of a heliostat field, which concentrates direct solar irradiation on an open volumetric central receiver. The receiver heats up ambient air to temperatures of around 700°C. The hot air's heat energy is transferred to a steam Rankine cycle in a heat recovery steam generator (HRSG). The steam drives a steam turbine, which in turn drives a generator for producing electricity. In order to increase the operational hours of a solar tower power plant, a heat storage system and/ or hybridization may be considered. The advantage of solar-fossil hybrid power plants, compared to solar-only systems, lies in low additional investment costs due to an adaptable solar share and reduced technical and economical risks. On sunny days the hybrid system operates in a solar-only mode with the central receiver and on cloudy days and at night with the gas turbine only. As an alternative to methane gas, environmentally neutral biogas can be used for operating the gas turbine. Hence, the hybrid system is operated to 100\% from renewable energy sources},
  language  = {en}
}
@article{StadlerGarveyBocahutetal.2012,
  author    = {Stadler, Andreas M. and Garvey, G. J. and Bocahut, A. and Sacquin-Mora, S. and Digel, Ilya and Schneider, G. J. and Natali, F. and Artmann, Gerhard and Zaccai, G.},
  title     = {Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics},
  series = {Journal of the Royal Society Interface},
  volume    = {9},
  journal   = {Journal of the Royal Society Interface},
  number    = {76},
  publisher = {The Royal Society},
  address   = {London},
  issn      = {1742-5689},
  doi       = {10.1098/rsif.2012.0364},
  pages     = {2845 -- 2855},
  year      = {2012},
  abstract  = {Thermodynamic stability, configurational motions and internal forces of haemoglobin (Hb) of three endotherms (platypus, Ornithorhynchus anatinus; domestic chicken, Gallus gallus domesticus and human, Homo sapiens) and an ectotherm (salt water crocodile, Crocodylus porosus) were investigated using circular dichroism, incoherent elastic neutron scattering and coarse-grained Brownian dynamics simulations. The experimental results from Hb solutions revealed a direct correlation between protein resilience, melting temperature and average body temperature of the different species on the 0.1 ns time scale. Molecular forces appeared to be adapted to permit conformational fluctuations with a root mean square displacement close to 1.2 {\AA} at the corresponding average body temperature of the endotherms. Strong forces within crocodile Hb maintain the amplitudes of motion within a narrow limit over the entire temperature range in which the animal lives. In fully hydrated powder samples of human and chicken, Hb mean square displacements and effective force constants on the 1 ns time scale showed no differences over the whole temperature range from 10 to 300 K, in contrast to the solution case. A complementary result of the study, therefore, is that one hydration layer is not sufficient to activate all conformational fluctuations of Hb in the pico- to nanosecond time scale which might be relevant for biological function. Coarse-grained Brownian dynamics simulations permitted to explore residue-specific effects. They indicated that temperature sensing of human and chicken Hb occurs mainly at residues lining internal cavities in the β-subunits.},
  language  = {en}
}
@article{ButenwegFehling2012,
  author    = {Butenweg, Christoph and Fehling, Ekkehard},
  title     = {Hintergrund f{\"u}r die vereinfachten Regeln bei Mauerwerksgeb{\"a}uden im Erdbebenfall},
  series = {Mauerwerk : European journal of masonry},
  volume    = {Volume 16},
  journal   = {Mauerwerk : European journal of masonry},
  number    = {Issue 3},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1437-1022 (E-Journal); 1432-3427 (Print)},
  doi       = {10.1002/dama.201200537},
  pages     = {127 -- 137},
  year      = {2012},
  abstract  = {Bei der Ausarbeitung des nationalen Anwendungsdokumentes zur DIN EN 1998-1 waren die in der ENV-Fassung enthaltenen vereinfachten Regeln im Lichte aktueller Forschungsergebnisse zu {\"u}berpr{\"u}fen und zu {\"u}berarbeiten. Die gleiche Aufgabe stellte sich auch f{\"u}r die Neufassung der DIN 4149. In beiden F{\"a}llen sind neben konstruktiven Regeln f{\"u}r die Art und Anordnung der zur Geb{\"a}udeaussteifung heranzuziehenden W{\"a}nde im Grundriss Tabellen enthalten, die unter bestimmten Bedingungen den Entfall eines rechnerischen Nachweises der Tragw{\"a}nde im Erdbebenfall erm{\"o}glichen. Dies ist f{\"u}r Schwachbebengebiete, wie sie in Deutschland und anderen L{\"a}ndern Mitteleuropas anzutreffen sind, sinnvoll, um unn{\"o}tigen Rechenaufwand sowie Probleme mit der F{\"u}hrbarkeit von Nachweisen so weit wie m{\"o}glich auszuschalten. Im vorliegenden Beitrag werden die Hintergr{\"u}nde der vereinfachten Regeln diskutiert und die Ergebnisse der Anwendung mit verschiedenen Rechenverfahren verglichen und bewertet.},
  language  = {de}
}
@article{ButenwegGellert2012,
  author    = {Butenweg, Christoph and Gellert, Christoph},
  title     = {Integrale Geb{\"a}udeplanung am Beispiel eines Geschossbaus in Ziegelmauerwerk},
  series = {Mauerwerk : European journal of masonry},
  volume    = {Volume 16},
  journal   = {Mauerwerk : European journal of masonry},
  number    = {5},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1437-1022 (E-Journal); 1432-3427 (Print)},
  doi       = {10.1002/dama.201200550},
  pages     = {247 -- 254},
  year      = {2012},
  abstract  = {Moderne Mauerwerksbauten m{\"u}ssen nach heutigen Anforderungen architektonisch, statisch, energetisch sowie schall- und brandschutztechnisch optimal ausgelegt sein. Aufgrund der Komplexit{\"a}t und engen Verzahnung der einzelnen Anforderungen ist eine integrale Geb{\"a}udeplanung zur Erzielung einer qualitativ hochwertigen Bauwerksl{\"o}sung unbedingt notwendig. Diese erfordert von den Fachplanern vertieftes Spezialwissen in den verschiedenen Bereichen, um insbesondere die Schnittstellen und Bauwerksdetails korrekt zu planen und auszuf{\"u}hren. Der Beitrag stellt die integrale Geb{\"a}udeplanung am Beispiel eines Geschossbaus in Ziegelbauweise mit L{\"o}sungen f{\"u}r wesentliche Detailpunkte vor},
  language  = {de}
}
@article{ButenwegHoltschoppen2012,
  author    = {Butenweg, Christoph and Holtschoppen, Britta},
  title     = {Neuer VCI-Leitfaden f{\"u}r die erdbebensichere Auslegung von Industrieanlagen},
  series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik},
  volume    = {Band 87},
  journal   = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen ; offizielle Zeitschrift der VDI-Gesellschaft Bautechnik},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {1436-4867 (E-Journal); 0005-6650 (Print)},
  pages     = {S18},
  year      = {2012},
  language  = {de}
}
@article{LoebSchartnerDachwaldetal.2012,
  author    = {Loeb, Horst Wolfgang and Schartner, Karl-Heinz and Dachwald, Bernd and Ohndorf, Andreas and Seboldt, Wolfgang},
  title     = {Interstellar heliopause probe},
  series = {Труды МАИ},
  journal   = {Труды МАИ},
  number    = {60},
  publisher = {Moskauer Staatliches Luftfahrtinstitut (МАИ)},
  address   = {Moskau},
  pages     = {2 -- 2},
  year      = {2012},
  abstract  = {There is common agreement within the scientific community that in order to understand our local galactic environment it will be necessary to send a spacecraft into the region beyond the solar wind termination shock. Considering distances of 200 AU for a new mission, one needs a spacecraft traveling at a speed of close to 10 AU/yr in order to keep the mission duration in the range of less than 25 yrs, a transfer time postulated by European Space Agency (ESA). Two propulsion options for the mission have been proposed and discussed so far: the solar sail propulsion and the ballistic/radioisotope-electric propulsion (REP). As a further alternative, we here investigate a combination of solar-electric propulsion (SEP) and REP. The SEP stage consists of six 22-cms diameter RIT-22 ion thrusters working with a high specific impulse of 7377 s corresponding to a positive grid voltage of 5 kV. Solar power of 53 kW at begin of mission (BOM) is provided by a lightweight solar array.},
  language  = {en}
}
@article{BorgmeierBongaertsMeinhardt2012,
  author    = {Borgmeier, Claudia and Bongaerts, Johannes and Meinhardt, Friedhelm},
  title     = {Genetic analysis of the Bacillus licheniformis degSU operon and the impact of regulatory mutations on protease production},
  series = {Journal of biotechnology},
  volume    = {159},
  journal   = {Journal of biotechnology},
  number    = {1-2},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1873-4863 (E-Journal); 0168-1656 (Print)},
  doi       = {10.1016/j.jbiotec.2012.02.011},
  pages     = {12 -- 20},
  year      = {2012},
  abstract  = {Disruption experiments targeted at the Bacillus licheniformis degSU operon and GFP-reporter analysis provided evidence for promoter activity immediately upstream of degU. pMutin mediated concomitant introduction of the degU32 allele - known to cause hypersecretion in Bacillus subtilis - resulted in a marked increase in protease activity. Application of 5-fluorouracil based counterselection through establishment of a phosphoribosyltransferase deficient Δupp strain eventually facilitated the marker-free introduction of degU32 leading to further protease enhancement achieving levels as for hypersecreting wild strains in which degU was overexpressed. Surprisingly, deletion of rapG - known to interfere with DegU DNA-binding in B. subtilis - did not enhance protease production neither in the wild type nor in the degU32 strain. The combination of degU32 and Δupp counterselection in the type strain is not only equally effective as in hypersecreting wild strains with respect to protease production but furthermore facilitates genetic strain improvement aiming at biological containment and effectiveness of biotechnological processes.},
  language  = {en}
}
@article{HasanKeilStaatetal.2012,
  author    = {Hasan, Istabrak and Keil, Ludger and Staat, Manfred and Wahl, Gerhard and Bourauel, Christoph},
  title     = {Determination of the frictional coefficient of the implant-antler interface : experimental approach},
  series = {Biomedical Engineering / Biomedizinische Technik},
  volume    = {57},
  journal   = {Biomedical Engineering / Biomedizinische Technik},
  number    = {5},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {1862-278X},
  pages     = {359 -- 363},
  year      = {2012},
  abstract  = {The similar bone structure of reindeer antler to human bone permits studying the osseointegration of dental implants in the jawbone. As the friction is one of the major factors that have a significant influence on the initial stability of immediately loaded dental implants, it is essential to define the frictional coefficient of the implant-antler interface. In this study, the kinetic frictional forces at the implant-antler interface were measured experimentally using an optomechanical setup and a stepping motor controller under different axial loads and sliding velocities. The corresponding mean values of the static and kinetic frictional coefficients were within the range of 0.5-0.7 and 0.3-0.5, respectively. An increase in the frictional forces with increasing applied axial loads was registered. The measurements showed an evidence of a decrease in the magnitude of the frictional coefficient with increasing sliding velocity. The results of this study provide a considerable assessment to clarify the suitable frictional coefficient to be used in the finite element contact analysis of antler specimens.},
  language  = {en}
}
@article{PoghossianWeilBaeckeretal.2012,
  author    = {Poghossian, Arshak and Weil, M. H. and B{\"a}cker, Matthias and Mayer, D. and Sch{\"o}ning, Michael Josef},
  title     = {Field-effect Devices Functionalised with Gold-Nanoparticle/Macromolecule Hybrids: New Opportunities for a Label-Free Biosensing},
  series = {Procedia Engineering},
  journal   = {Procedia Engineering},
  number    = {47},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2012.09.136},
  pages     = {273 -- 276},
  year      = {2012},
  abstract  = {Field-effect capacitive electrolyte-insulator-semiconductor (EIS) sensors functionalised with citrate-capped gold nanoparticles (AuNP) have been used for the electrostatic detection of macromolecules by their intrinsic molecular charge. The EIS sensor detects the charge changes in the AuNP/macromolecule hybrids induced by the adsorption or binding events. A feasibility of the proposed detection scheme has been exemplary demonstrated by realising EIS sensors for the detection of poly-D-lysine molecules.},
  language  = {en}
}
@article{Weigand2012,
  author    = {Weigand, Christoph},
  title     = {Statistical Tests Based on Reliability and Precision},
  series = {Economic Quality Control : EQC ; international journal for quality and reliability},
  volume    = {27},
  journal   = {Economic Quality Control : EQC ; international journal for quality and reliability},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {1869-6147},
  doi       = {10.1515/eqc-2012-0002},
  pages     = {43 -- 64},
  year      = {2012},
  abstract  = {The construction of a statistical test is investigated which is based only on "reliability" and "precision" as quality criteria. The reliability of a statistical test is quantifiedin a straightforward way by the probability that the decision of the test is correct. However, the quantification of the precision of a statistical test is not at all evident. Thereforethe paper presents and discusses several approaches. Moreover the distinction of "nullhypothesis" and "alternative hypothesis" is not necessary any longer.},
  language  = {en}
}
@article{SchoeningBiselliSelmeretal.2012,
  author    = {Sch{\"o}ning, Michael Josef and Biselli, Manfred and Selmer, Thorsten and {\"O}hlschl{\"a}ger, Peter and Baumann, Marcus and F{\"o}rster, Arnold and Poghossian, Arshak},
  title     = {Forschung „zwischen" den Disziplinen: das Institut f{\"u}r Nano- und Biotechnologien},
  series = {Analytik news : das Online-Labormagazin f{\"u}r Labor und Analytik},
  volume    = {Publ. online},
  journal   = {Analytik news : das Online-Labormagazin f{\"u}r Labor und Analytik},
  publisher = {Dr. Beyer Internet-Beratung},
  address   = {Ober-Ramstadt},
  pages     = {11 Seiten},
  year      = {2012},
  abstract  = {"Biologie trifft Mikroelektronik", das Motto des Instituts f{\"u}r Nano- und Biotechnologien (INB) an der FH Aachen, unterstreicht die zunehmende Bedeutung interdisziplin{\"a}r gepr{\"a}gter Forschungsaktivit{\"a}ten. Der thematische Zusammenschluss grundst{\"a}ndiger Disziplinen, wie die Physik, Elektrotechnik, Chemie, Biologie sowie die Materialwissenschaften, l{\"a}sst neue Forschungsgebiete entstehen, ein herausragendes Beispiel hierf{\"u}r ist die Nanotechnologie: Hier werden neue Werkstoffe und Materialien entwickelt, einzelne Nanopartikel oder Molek{\"u}le und deren Wechselwirkung untersucht oder Schichtstrukturen im Nanometerbereich aufgebaut, die neue und vorher nicht bekannte Eigenschaften hervorbringen. Vor diesem Hintergrund b{\"u}ndelt das im Jahre 2006 gegr{\"u}ndete INB die an der FH Aachen vorhandenen Kompetenzen von derzeit insgesamt sieben Laboratorien auf den Gebieten der Halbleitertechnik und Nanoelektronik, Nanostrukturen und DNA-Sensorik, der Chemo- und Biosensorik, der Enzymtechnologie, der Mikrobiologie und Pflanzenbiotechnologie, der Zellkulturtechnik, sowie der Roten Biotechnologie synergetisch. In der Nano- und Biotechnologie steckt außergew{\"o}hnliches Potenzial! Nicht zuletzt deshalb stellen sich die Forscher der Herausforderung, in diesem Bereich gemeinsam zu forschen und Schnittstellen zu nutzen, um so bei der Gestaltung neuartiger Ideen und Produkte mitzuwirken, die zuk{\"u}nftig unser allt{\"a}gliches Leben ver{\"a}ndern werden. Im Folgenden werden die verschiedenen Forschungsbereiche kurz zusammenfassend vorgestellt und vorhandene Interaktionen anhand von exemplarisch ausgew{\"a}hlten, aktuellen Forschungsprojekten skizziert.},
  language  = {de}
}
@article{SchusserPoghossianBaeckeretal.2012,
  author    = {Schusser, Sebastian and Poghossian, Arshak and B{\"a}cker, Matthias and Leinhos, Marcel and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Characterization of biodegradable polymers with capacitive field-effect sensors},
  series = {Sensors and actuators B: Chemical},
  volume    = {187},
  journal   = {Sensors and actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2012.07.099},
  pages     = {2 -- 7},
  year      = {2012},
  abstract  = {In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor.},
  language  = {en}
}
@article{BaeckerRaueSchusseretal.2012,
  author    = {B{\"a}cker, Matthias and Raue, Markus and Schusser, Sebastian and Jeitner, C. and Breuer, L. and Wagner, P. and Poghossian, Arshak and F{\"o}rster, Arnold and Mang, Thomas and Sch{\"o}ning, Michael Josef},
  title     = {Microfluidic chip with integrated microvalves based on temperature- and pH-responsive hydrogel thin films},
  series = {Physica Status Solidi (a)},
  volume    = {209},
  journal   = {Physica Status Solidi (a)},
  number    = {5},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201100763},
  pages     = {839 -- 845},
  year      = {2012},
  abstract  = {Two types of microvalves based on temperature-responsive poly(N-isopropylacrylamide) (PNIPAAm) and pH-responsive poly(sodium acrylate) (PSA) hydrogel films have been developed and tested. The PNIPAAm and PSA hydrogel films were prepared by means of in situ photopolymerization directly inside the fluidic channel of a microfluidic chip fabricated by combining Si and SU-8 technologies. The swelling/shrinking properties and height changes of the PNIPAAm and PSA films inside the fluidic channel were studied at temperatures of deionized water from 14 to 36 °C and different pH values (pH 3-12) of Titrisol buffer, respectively. Additionally, in separate experiments, the lower critical solution temperature (LCST) of the PNIPAAm hydrogel was investigated by means of a differential scanning calorimetry (DSC) and a surface plasmon resonance (SPR) method. Mass-flow measurements have shown the feasibility of the prepared hydrogel films to work as an on-chip integrated temperature- or pH-responsive microvalve capable to switch the flow channel on/off.},
  language  = {en}
}
@article{SchifferFerreinLakemeyer2012,
  author    = {Schiffer, Stefan and Ferrein, Alexander and Lakemeyer, Gerhard},
  title     = {Caesar: an intelligent domestic service robot},
  series = {Intelligent service robotics},
  volume    = {5},
  journal   = {Intelligent service robotics},
  number    = {4},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1861-2776},
  doi       = {10.1007/s11370-012-0118-y},
  pages     = {259 -- 276},
  year      = {2012},
  abstract  = {In this paper we present CAESAR, an intelligent domestic service robot. In domestic settings for service robots complex tasks have to be accomplished. Those tasks benefit from deliberation, from robust action execution and from flexible methods for human-robot interaction that account for qualitative notions used in natural language as well as human fallibility. Our robot CAESAR deploys AI techniques on several levels of its system architecture. On the low-level side, system modules for localization or navigation make, for instance, use of path-planning methods, heuristic search, and Bayesian filters. For face recognition and human-machine interaction, random trees and well-known methods from natural language processing are deployed. For deliberation, we use the robot programming and plan language READYLOG, which was developed for the high-level control of agents and robots; it allows combining programming the behaviour using planning to find a course of action. READYLOG is a variant of the robot programming language Golog. We extended READYLOG to be able to cope with qualitative notions of space frequently used by humans, such as "near" and "far". This facilitates human-robot interaction by bridging the gap between human natural language and the numerical values needed by the robot. Further, we use READYLOG to increase the flexible interpretation of human commands with decision-theoretic planning. We give an overview of the different methods deployed in CAESAR and show the applicability of a system equipped with these AI techniques in domestic service robotics},
  language  = {en}
}
@article{BeckerDelfmannEggertetal.2012,
  author    = {Becker, J{\"o}rg and Delfmann, Patrick and Eggert, Mathias and Schwittay, Sebastian},
  title     = {Generalizability and Applicability of Model-Based Business Process Compliance-Checking Approaches — A State-of-the-Art Analysis and Research Roadmap},
  series = {Business Research : BuR},
  volume    = {5},
  journal   = {Business Research : BuR},
  number    = {2},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {1866-8658},
  doi       = {10.1007/BF03342739},
  pages     = {221 -- 247},
  year      = {2012},
  abstract  = {With a steady increase of regulatory requirements for business processes, automation support of compliance management is a field garnering increasing attention in Information Systems research. Several approaches have been developed to support compliance checking of process models. One major challenge for such approaches is their ability to handle different modeling techniques and compliance rules in order to enable widespread adoption and application. Applying a structured literature search strategy, we reflect and discuss compliance-checking approaches in order to provide an insight into their generalizability and evaluation. The results imply that current approaches mainly focus on special modeling techniques and/or a restricted set of types of compliance rules. Most approaches abstain from real-world evaluation which raises the question of their practical applicability. Referring to the search results, we propose a roadmap for further research in model-based business process compliance checking.},
  language  = {en}
}
@article{Baehr2012,
  author    = {B{\"a}hr, Brigitte},
  title     = {[Gert Hoepner] im Interview zum Thema ; Verpackungspolitik - mehr als H{\"u}lle},
  series = {Packaging journal : Technologie, Logistik, Marketing, Produkte},
  journal   = {Packaging journal : Technologie, Logistik, Marketing, Produkte},
  number    = {5},
  publisher = {Ella Verlag},
  address   = {H{\"u}rth},
  issn      = {1610-0336},
  pages     = {78 -- 80},
  year      = {2012},
  language  = {de}
}
@article{LempiaeinenCouttetBolognanietal.2012,
  author    = {Lempi{\"a}inen, Harri and Couttet, Philippe and Bolognani, Federico and M{\"u}ller, Arne and Dubost, Val{\´e}rie and Luisier, Rapha{\"e}lle and Rio-Espinola, Alberto del and Vitry, Veronique and Unterberger, Elif B. and Thomson, John P. and Treindl, Fridolin and Metzger, Ute and Wrzodek, Clemens and Hahne, Florian and Zollinger, Tulipan and Brasa, Sarah and Kalteis, Magdalena and Marcellin, Magali and Giudicelli, Fanny and Braeuning, Albert and Morawiec, Laurent and Zamurovic, Natasa and L{\"a}ngle, Ulrich and Scheer, Nico and Sch{\"u}beler, Dirk and Goodman, Jay and Chibout, Salah-Dine and Marlowe, Jennifer and Theil, Dietlinde and Heard, David J. and Grenet, Olivier and Zell, Andreas and Templin, Markus F. and Meehan, Richard R. and Wolf, Roland C. and Elcombe, Clifford R. and Schwarz, Michael and Moulin, Pierre and Terranova, R{\´e}mi and Moggs, Jonathan G.},
  title     = {Identification of Dlk1-Dio3 imprinted gene cluster non-coding RNAs as novel candidate biomarkers for liver tumor promotion},
  series = {Toxicological Sciences},
  volume    = {131},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {10.1093/toxsci/kfs303},
  pages     = {375 -- 386},
  year      = {2012},
  abstract  = {The molecular events during nongenotoxic carcinogenesis and their temporal order are poorly understood but thought to include long-lasting perturbations of gene expression. Here, we have investigated the temporal sequence of molecular and pathological perturbations at early stages of phenobarbital (PB) mediated liver tumor promotion in vivo. Molecular profiling (mRNA, microRNA [miRNA], DNA methylation, and proteins) of mouse liver during 13 weeks of PB treatment revealed progressive increases in hepatic expression of long noncoding RNAs and miRNAs originating from the Dlk1-Dio3 imprinted gene cluster, a locus that has recently been associated with stem cell pluripotency in mice and various neoplasms in humans. PB induction of the Dlk1-Dio3 cluster noncoding RNA (ncRNA) Meg3 was localized to glutamine synthetase-positive hypertrophic perivenous hepatocytes, sug- gesting a role for β-catenin signaling in the dysregulation of Dlk1-Dio3 ncRNAs. The carcinogenic relevance of Dlk1-Dio3 locus ncRNA induction was further supported by in vivo genetic dependence on constitutive androstane receptor and β-catenin pathways. Our data identify Dlk1-Dio3 ncRNAs as novel candidate early biomarkers for mouse liver tumor promotion and provide new opportunities for assessing the carcinogenic potential of novel compounds.},
  language  = {en}
}
@article{Wolf2012,
  author    = {Wolf, Martin R.},
  title     = {Von Security Awareness zum Secure Behaviour},
  series = {Hakin9 Extra - IT-Forensik},
  volume    = {2012},
  journal   = {Hakin9 Extra - IT-Forensik},
  number    = {5},
  publisher = {Software Wydawnictwo},
  address   = {Warszawa},
  issn      = {1733-7186},
  pages     = {18 -- 19},
  year      = {2012},
  abstract  = {Security Awareness ist derzeit ein viel diskutiertes Thema. Es reicht nicht, einfach nur ein paar technische Systeme (z.B. Firewalls) zu installieren, um ein angemessenes Schutzniveau zu erzielen. Neben einer guten Organisation von IT Security ist es auch notwendig, den Mitarbeiter einzubinden. Der vielzitierte "Faktor Mensch" ist derjenige, der die Technik korrekt anwenden muss und der durch falsches Verhalten technische und organisatorische Schutzmaßnahmen aushebeln kann. Deshalb reicht es nicht aus, wenn sich der Mitarbeiter der Gefahren bewusst ("aware") ist, er muss auch dementsprechend "sicher" handeln.},
  language  = {de}
}
@article{RiglingElkinDobbertinetal.2012,
  author    = {Rigling, Andreas and Elkin, Ch{\´e} and Dobbertin, Matthias and Eilmann, Britta and Giuggiola, Arnaud and Wohlgemuth, Thomas and Bugmann, Harald},
  title     = {Wald und Klimawandel in der inneralpinen Trockenregion Visp},
  series = {Schweizerische Zeitschrift f{\"u}r Forstwesen},
  volume    = {163},
  journal   = {Schweizerische Zeitschrift f{\"u}r Forstwesen},
  number    = {12},
  publisher = {Schweizerischer Forstverein},
  address   = {Z{\"u}rich},
  issn      = {2235-1469 (Online)},
  doi       = {10.3188/szf.2012.0481},
  pages     = {481 -- 492},
  year      = {2012},
  abstract  = {Der Temperaturanstieg der vergangenen Jahrzehnte war in Gebirgsregionen besonders ausgepr{\"a}gt. Sollte sich dieser Temperaturtrend im 21. Jahrhundert fortsetzen, dann d{\"u}rf-ten sich auch die H{\"a}ufigkeit und Intensit{\"a}t von Niederschl{\"a}-gen und Trockenperioden ver{\"a}ndern, was die Waldwirtschaft vor grosse Herausforderungen stellen wird. Trockenheit ist ein entscheidender Faktor f{\"u}r die Wald{\"o}kosysteme der inner-alpinen T{\"a}ler, wo seit Jahren trockenheitsbedingtes Baum-sterben festgestellt wird. Der vorliegende Beitrag hat zum Ziel, die Sensitivit{\"a}t der verschiedenen Wald{\"o}kosysteme ge-gen{\"u}ber Klimawandel und alternative, teilweise extreme Bewirtschaftungsvarianten in der Region Visp zu testen. Me-thodische Ans{\"a}tze wie Monitoring, Feldexperimente und dy-namische Modellierung wurden kombiniert, und es wurden verschiedene {\"O}kosystemleistungen ber{\"u}cksichtigt, so Holz-produktion, Schutz vor Naturgefahren, Kohlenstoffspeiche-rung und Aspekte der Biodiversit{\"a}t. Die Resultate deuten da-rauf hin, dass auf den Trockenstandorten der Tieflagen die einheimischen Baumarten an ihre physiologischen Grenzen stossen und l{\"a}ngerfristig {\"u}ber alternative Baumarten nach-gedacht werden sollte. In den mittleren Lagen d{\"u}rften Tro-ckenheit und Schadinsekten wie die Borkenk{\"a}fer die zuk{\"u}nf-tige Waldentwicklung steuern. In den Hochlagen hingegen werden sich die W{\"a}lder ausdehnen und besser wachsen als heute. Alle untersuchten {\"O}kosystemleistungen werden ge-bietsweise starken Ver{\"a}nderungen unterworfen sein. Die dis-kutierten Bewirtschaftungsvarianten scheinen dazu geeignet, die Wasserverf{\"u}gbarkeit der Best{\"a}nde, haupts{\"a}chlich in tief-eren Lagen, zu erh{\"o}hen und dadurch die Widerstandskraft der B{\"a}ume gegen{\"u}ber Trockenperioden vor{\"u}bergehend zu st{\"a}rken. Es ist aber davon ausgehen, dass nur verh{\"a}ltnism{\"a}s-sig starke Eingriffe wesentliche Effekte erzielen k{\"o}nnen. Die Verkn{\"u}pfung von Umweltmonitoring, Feldexperimenten und Modellierung unter Miteinbezug von {\"O}kosystemleistungen ist vielversprechend, da sie eine differenzierte Absch{\"a}tzung des zuk{\"u}nftigen Landschaftswandels und seiner Effekte auf die Waldleistungen erm{\"o}glicht.},
  language  = {de}
}
@article{FerreinMeyer2012,
  author    = {Ferrein, Alexander and Meyer, Thomas},
  title     = {A Brief Overview of Artificial Intelligence in South Africa},
  series = {AI Magazine},
  volume    = {33},
  journal   = {AI Magazine},
  number    = {1},
  publisher = {AAAI},
  address   = {Menlo Park},
  issn      = {0738-4602},
  doi       = {10.1609/aimag.v33i1.2357},
  pages     = {99 -- 101},
  year      = {2012},
  abstract  = {South Africa in recent years is the establishment of a number of research hubs involved in AI activities ranging from mobile robotics and computational intelligence, to knowledge representation and reasoning, and human language technologies. In this survey we take the reader through a quick tour of the research being conducted at these hubs, and touch on an initiative to maintain and extend the current level of interest in AI research in the country.},
  language  = {en}
}
@article{BragardvanHoekDeDoncker2012,
  author    = {Bragard, Michael and van Hoek, H. and De Doncker, R. W.},
  title     = {A major design step in IETO concept realization that allows overcurrent protection and pushes limits of switching performance},
  series = {IEEE transactions on power electronics},
  volume    = {27},
  journal   = {IEEE transactions on power electronics},
  number    = {9},
  publisher = {IEEE},
  address   = {New York},
  issn      = {0885-8993},
  doi       = {10.1109/TPEL.2012.2189136},
  pages     = {4163 -- 4171},
  year      = {2012},
  abstract  = {This paper presents the latest prototype of the integrated emitter turn-off thyristor concept, which potentially ranks among thyristor high-power devices like the gate turn-off thyristor and the integrated gate-commutated thyristor (IGCT). Due to modifications of the external driver stage and mechanical press-pack design optimization, this prototype allows for full device characterization. The turn-off capability was increased to 1600 A with an active silicon area of 823mm2 . This leads to a transient peak power of 672.1kW/cm² . Within this paper, measurements and concept assessment are presented and a comparison to state-of-the-art IGCT devices is provided.},
  language  = {en}
}
@article{ScheerBalimaneHaywardetal.2012,
  author    = {Scheer, Nico and Balimane, Praveen and Hayward, Michael D. and Buechel, Sandra and Kauselmann, Gunther and Wolf, C. Roland},
  title     = {Generation and Characterization of a Novel Multidrug Resistance Protein 2 Humanized Mouse Line},
  series = {Drug Metabolism and Disposition},
  volume    = {40},
  journal   = {Drug Metabolism and Disposition},
  number    = {11},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/dmd.112.047605},
  pages     = {2212 -- 2218},
  year      = {2012},
  abstract  = {The multidrug resistance protein (MRP) 2 is predominantly expressed in liver, intestine, and kidney, where it plays an important role in the excretion of a range of drugs and their metabolites or endogenous compounds into bile, feces, and urine. Mrp knockout [Mrp2(-/-)] mice have been used recently to study the role of MRP2 in drug disposition. Here, we describe the first generation and initial characterization of a mouse line humanized for MRP2 (huMRP2), which is nulled for the mouse Mrp2 gene and expresses the human transporter in the organs and cell types where MRP2 is normally expressed. Analysis of the mRNA expression for selected cytochrome P450 and transporter genes revealed no major changes in huMRP2 mice compared with wild-type controls. We show that human MRP2 is able to compensate functionally for the loss of the mouse transporter as demonstrated by comparable bilirubin levels in the humanized mice and wild-type controls, in contrast to the hyperbilirubinemia phenotype that is observed in MRP2(-/-) mice. The huMRP2 mouse provides a model to study the role of the human transporter in drug disposition and in assessing the in vivo consequences of inhibiting this transporter by compounds interacting with human MRP2.},
  language  = {en}
}
@article{FrauenrathFuchsDieringeretal.2012,
  author    = {Frauenrath, Tobias and Fuchs, Katharina and Dieringer, Matthias A. and {\"O}zerdem, Celal and Patel, Nishan and Renz, Wolfgang and Greiser, Andreas and Elgeti, Thomas and Niendorf, Thoralf},
  title     = {Detailing the use of magnetohydrodynamic effects for synchronization of MRI with the cardiac cycle: A feasibility study},
  series = {Journal of Magnetic Resonance Imaging},
  volume    = {36},
  journal   = {Journal of Magnetic Resonance Imaging},
  number    = {2},
  publisher = {Wiley-Liss},
  address   = {New York},
  issn      = {1522-2586},
  doi       = {10.1002/jmri.23634},
  pages     = {364 -- 372},
  year      = {2012},
  abstract  = {Purpose: To investigate the feasibility of using magnetohydrodynamic (MHD) effects for synchronization of magnetic resonance imaging (MRI) with the cardiac cycle. Materials and Methods: The MHD effect was scrutinized using a pulsatile flow phantom at B0 = 7.0 T. MHD effects were examined in vivo in healthy volunteers (n = 10) for B0 ranging from 0.05-7.0 T. Noncontrast-enhanced MR angiography (MRA) of the carotids was performed using a gated steady-state free-precession (SSFP) imaging technique in conjunction with electrocardiogram (ECG) and MHD synchronization. Results: The MHD potential correlates with flow velocities derived from phase contrast MRI. MHD voltages depend on the orientation between B0 and the flow of a conductive fluid. An increase in the interelectrode spacing along the flow increases the MHD potential. In vivo measurement of the MHD effect provides peak voltages of 1.5 mV for surface areas close to the common carotid artery at B0 = 7.0 T. Synchronization of MRI with the cardiac cycle using MHD triggering is feasible. MHD triggered MRA of the carotids at 3.0 T showed an overall image quality and richness of anatomic detail, which is comparable to ECG-triggered MRAs. Conclusion: This feasibility study demonstrates the use of MHD effects for synchronization of MR acquisitions with the cardiac cycle. J. Magn. Reson. Imaging 2012;36:364-372. © 2012 Wiley Periodicals, Inc.},
  language  = {en}
}
@article{EilmannRigling2012,
  author    = {Eilmann, Britta and Rigling, Andreas},
  title     = {Tree-growth analyses to estimate tree species' drought tolerance},
  series = {Tree Physiology},
  volume    = {32},
  journal   = {Tree Physiology},
  number    = {2},
  editor    = {Abrams, Marc},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {0829-318X (Print)},
  doi       = {10.1093/treephys/tps004},
  pages     = {178 -- 187},
  year      = {2012},
  abstract  = {Climate change is challenging forestry management and practices. Among other things, tree species with the ability to cope with more extreme climate conditions have to be identified. However, while environmental factors may severely limit tree growth or even cause tree death, assessing a tree species' potential for surviving future aggravated environmental conditions is rather demanding. The aim of this study was to find a tree-ring-based method suitable for identifying very drought-tolerant species, particularly potential substitute species for Scots pine (Pinus sylvestris L.) in Valais. In this inner-Alpine valley, Scots pine used to be the dominating species for dry forests, but today it suffers from high drought-induced mortality. We investigate the growth response of two native tree species, Scots pine and European larch (Larix decidua Mill.), and two non-native species, black pine (Pinus nigra Arnold) and Douglas fir (Pseudotsuga menziesii Mirb. var. menziesii), to drought. This involved analysing how the radial increment of these species responded to increasing water shortage (abandonment of irrigation) and to increasingly frequent drought years. Black pine and Douglas fir are able to cope with drought better than Scots pine and larch, as they show relatively high radial growth even after irrigation has been stopped and a plastic growth response to drought years. European larch does not seem to be able to cope with these dry conditions as it lacks the ability to recover from drought years. The analysis of trees' short-term response to extreme climate events seems to be the most promising and suitable method for detecting how tolerant a tree species is towards drought. However, combining all the methods used in this study provides a complete picture of how water shortage could limit species.},
  language  = {en}
}
@article{RiglingBiglerEilmannetal.2012,
  author    = {Rigling, Andreas and Bigler, Christof and Eilmann, Britta and Feldmeyer-Christe, Elisabeth and Gimmi, Urs and Ginzler, Christian and Graf, Ulrich and Mayer, Phillip and Vacchiano, Giorgio and Weber, Pascal and Wohlgemuth, Thomas and zweifel, Roman and Dobbertin, Matthias},
  title     = {Driving factors of a vegetation shift from Scots pine to pubescent oak in dry Alpine forests},
  series = {Global Change Biology},
  volume    = {19},
  journal   = {Global Change Biology},
  number    = {1},
  publisher = {Wiley-Blackwell},
  address   = {Oxford},
  issn      = {1354-1013 (Print)},
  doi       = {10.1111/gcb.12038},
  pages     = {229 -- 240},
  year      = {2012},
  abstract  = {An increasing number of studies have reported on forest declines and vegetation shifts triggered by drought. In the Swiss Rhone valley (Valais), one of the driest inner-Alpine regions, the species composition in low elevation forests is changing: The sub-boreal Scots pine (Pinus sylvestris L.) dominating the dry forests is showing high mortality rates. Concurrently the sub-Mediterranean pubescent oak (Quercus pubescens Willd.) has locally increased in abundance. However, it remains unclear whether this local change in species composition is part of a larger-scale vegetation shift. To study variability in mortality and regeneration in these dry forests we analysed data from the Swiss national forest inventory (NFI) on a regular grid between 1983 and 2003, and combined it with annual mortality data from a monitoring site. Pine mortality was found to be highest at low elevation (below 1000 m a.s.l.). Annual variation in pine mortality was correlated with a drought index computed for the summer months prior to observed tree death. A generalized linear mixed-effects model indicated for the NFI data increased pine mortality on dryer sites with high stand competition, particularly for small-diameter trees. Pine regeneration was low in comparison to its occurrence in the overstorey, whereas oak regeneration was comparably abundant. Although both species regenerated well at dry sites, pine regeneration was favoured at cooler sites at higher altitude and oak regeneration was more frequent at warmer sites, indicating a higher adaptation potential of oaks under future warming. Our results thus suggest that an extended shift in species composition is actually occurring in the pine forests in the Valais. The main driving factors are found to be climatic variability, particularly drought, and variability in stand structure and topography. Thus, pine forests at low elevations are developing into oak forests with unknown consequences for these ecosystems and their goods and services.},
  language  = {en}
}
@article{BragardBragard2012,
  author    = {Bragard, G. and Bragard, Michael},
  title     = {Ein kosteng{\"u}nstiges, universelles Modellbauinterface},
  series = {Der mathematische und naturwissenschaftliche Unterricht : MNU ; Organ des Deutschen Vereins zur F{\"o}rderung des Mathematischen und Naturwissenschaftlichen Unterrichts e.V.},
  volume    = {65},
  journal   = {Der mathematische und naturwissenschaftliche Unterricht : MNU ; Organ des Deutschen Vereins zur F{\"o}rderung des Mathematischen und Naturwissenschaftlichen Unterrichts e.V.},
  number    = {5},
  publisher = {Seeberger},
  address   = {Neuss},
  issn      = {0025-5866},
  pages     = {290 -- 293},
  year      = {2012},
  abstract  = {Wir stellen einen USB-Baustein vor, der eine kosteng{\"u}nstige und universelle M{\"o}glichkeit schafft , im Unterricht den Themenkreis Messen-Steuern-Regeln zu behandeln. Die Funktionalit{\"a}t orientiert sich am CVK-Interface der Firma Fischertechnik. Im Gegensatz zu kommerziellen L{\"o}sungen erlaubt unser Aufbau auch den preiswerten Einsatz in Gruppen- oder Einzelarbeit. Abschließend berichten wir {\"u}ber ein Beispiel aus dem Unterrichtseinsatz.},
  language  = {de}
}
@article{AbouzarPoghossianCherstvyetal.2012,
  author    = {Abouzar, Maryam H. and Poghossian, Arshak and Cherstvy, Andrey G. and Pedraza, Angela M. and Ingebrandt, Sven and Sch{\"o}ning, Michael Josef},
  title     = {Label-free electrical detection of DNA by means of field-effect nanoplate capacitors: Experiments and modeling},
  series = {Physica Status Solidi (a)},
  volume    = {209},
  journal   = {Physica Status Solidi (a)},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1862-6319},
  doi       = {10.1002/pssa.201100710},
  pages     = {925 -- 934},
  year      = {2012},
  abstract  = {Label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization/denaturation by means of an array of individually addressable field-effect-based nanoplate silicon-on-insulator (SOI) capacitors modified with gold nanoparticles (Au-NP) is investigated. The proposed device detects charge changes on Au-NP/DNA hybrids induced by the hybridization or denaturation event. DNA hybridization was performed in a high ionic-strength solution to provide a high hybridization efficiency. On the other hand, to reduce the screening of the DNA charge by counter ions and to achieve a high sensitivity, the sensor signal induced by the hybridization and denaturation events was measured in a low ionic-strength solution. High sensor signals of about 120, 90, and 80 mV were registered after the DNA hybridization, denaturation, and re-hybridization events, respectively. Fluorescence microscopy has been applied as reference method to verify the DNA immobilization, hybridization, and denaturation processes. An electrostatic charge-plane model for potential changes at the gate surface of a nanoplate field-effect sensor induced by the DNA hybridization has been developed taking into account both the Debye length and the distance of the DNA charge from the gate surface.},
  language  = {en}
}
@article{Staat2012,
  author    = {Staat, Manfred},
  title     = {Limit and shakedown analysis under uncertainty},
  series = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang},
  volume    = {19},
  journal   = {Tap chi Khoa hoc \& ung dung - Dai hoc Ton Duc Thang},
  pages     = {45 -- 47},
  year      = {2012},
  language  = {en}
}
@article{HuckPoghossianWagneretal.2012,
  author    = {Huck, Christina and Poghossian, Arshak and Wagner, Patrick and Sch{\"o}ning, Michael Josef},
  title     = {Combined amperometric/field-effect sensor for the detection of dissolved hydrogen},
  series = {Sensors and actuators B: Chemical},
  volume    = {187},
  journal   = {Sensors and actuators B: Chemical},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0925-4005},
  doi       = {10.1016/j.snb.2012.10.050},
  pages     = {168 -- 173},
  year      = {2012},
  abstract  = {Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3\% (v/v) with a slope of 198.4 ± 13.7 nA/\% (v/v) and 14.9 ± 0.5 mV/\% (v/v), respectively.},
  language  = {en}
}
@article{StaatVu2012,
  author    = {Staat, Manfred and Vu, Duc Khoi},
  title     = {Limit analysis of flaws in pressurized pipes and cylindrical vessels Part II: Circumferential defects},
  series = {Engineering Fracture Mechanics ; 97(2013), H. 1},
  volume    = {97},
  journal   = {Engineering Fracture Mechanics ; 97(2013), H. 1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0013-7944},
  doi       = {10.1016/j.engfracmech.2012.05.017},
  pages     = {314 -- 333},
  year      = {2012},
  abstract  = {Upper and lower bound theorems of limit analyses have been presented in part I of the paper. Part II starts with the finite element discretization of these theorems and demonstrates how both can be combined in a primal-dual optimization problem. This recently proposed numerical method is used to guide the development of a new class of closed-form limit loads for circumferential defects, which show that only large defects contribute to plastic collapse with a rapid loss of strength with increasing crack sizes. The formulae are compared with primal-dual FEM limit analyses and with burst tests. Even closer predictions are obtained with iterative limit load solutions for the von Mises yield function and for the Tresca yield function. Pressure loading of the faces of interior cracks in thick pipes reduces the collapse load of circumferential defects more than for axial flaws. Axial defects have been treated in part I of the paper.},
  language  = {en}
}
@article{GrandeMeffertSchoenbergeretal.2012,
  author    = {Grande, Marion and Meffert, Elisabeth and Schoenberger, Eva and Jung, Stefanie and Frauenrath, Tobias and Huber, Walter and Hussmann, Katja and Moormann, Mareike and Heim, Stefan},
  title     = {From a concept to a word in a syntactically complete sentence: An fMRI study on spontaneous language production in an overt picture description task},
  series = {NeuroImage},
  volume    = {61},
  journal   = {NeuroImage},
  number    = {3},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1522-2586},
  doi       = {10.1016/j.neuroimage.2012.03.087},
  pages     = {702 -- 714},
  year      = {2012},
  abstract  = {Spontaneous language has rarely been subjected to neuroimaging studies. This study therefore introduces a newly developed method for the analysis of linguistic phenomena observed in continuous language production during fMRI. Most neuroimaging studies investigating language have so far focussed on single word or — to a smaller extent — sentence processing, mostly due to methodological considerations. Natural language production, however, is far more than the mere combination of words to larger units. Therefore, the present study aimed at relating brain activation to linguistic phenomena like word-finding difficulties or syntactic completeness in a continuous language fMRI paradigm. A picture description task with special constraints was used to provoke hesitation phenomena and speech errors. The transcribed speech sample was segmented into events of one second and each event was assigned to one category of a complex schema especially developed for this purpose. The main results were: conceptual planning engages bilateral activation of the precuneus. Successful lexical retrieval is accompanied - particularly in comparison to unsolved word-finding difficulties - by the left middle and superior temporal gyrus. Syntactic completeness is reflected in activation of the left inferior frontal gyrus (IFG) (area 44). In sum, the method has proven to be useful for investigating the neural correlates of lexical and syntactic phenomena in an overt picture description task. This opens up new prospects for the analysis of spontaneous language production during fMRI.},
  language  = {en}
}
@article{VerbanellaFabo2012,
  author    = {Verbanella, Stresa and Fabo, Sabine},
  title     = {Mit Pinsel und Farbe hacken : Interview mit Sabine Fabo},
  series = {Remotewords.net},
  journal   = {Remotewords.net},
  year      = {2012},
  abstract  = {Remotewords makes its mark on the picturesque "Bar Verbanella", located in Stresa near Isola Bella on Lago Maggiore. The words CUM GRANO SALIS (with a grain of salt) by Sabine Fabo, art theorist on media contexts, were applied to its roof in collaboration with the German-Italian art organization "Lo spirito del Lago".},
  language  = {de}
}
@article{ScheerKapelyukhRodeetal.2012,
  author    = {Scheer, Nico and Kapelyukh, Yury and Rode, Anja and Buechel, Sandra and Wolf, C. Roland},
  title     = {Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines},
  series = {Molecular Pharmacology},
  volume    = {82},
  journal   = {Molecular Pharmacology},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-0111},
  doi       = {10.1124/mol.112.080036},
  pages     = {1022 -- 1029},
  year      = {2012},
  abstract  = {Compared with rodents and many other animal species, the human cytochrome P450 (P450) Cyp2c gene cluster varies significantly in the multiplicity of functional genes and in the substrate specificity of its enzymes. As a consequence, the use of wild-type animal models to predict the role of human CYP2C enzymes in drug metabolism and drug-drug interactions is limited. Within the human CYP2C cluster CYP2C9 is of particular importance, because it is one of the most abundant P450 enzymes in human liver, and it is involved in the metabolism of a wide variety of important drugs and environmental chemicals. To investigate the in vivo functions of cytochrome P450 Cyp2c genes and to establish a model for studying the functions of CYP2C9 in vivo, we have generated a mouse model with a deletion of the murine Cyp2c gene cluster and a corresponding humanized model expressing CYP2C9 specifically in the liver. Despite the high number of functional genes in the mouse Cyp2c cluster and the reported roles of some of these proteins in different biological processes, mice deleted for Cyp2c genes were viable and fertile but showed certain phenotypic alterations in the liver. The expression of CYP2C9 in the liver also resulted in viable animals active in the metabolism and disposition of a number of CYP2C9 substrates. These mouse lines provide a powerful tool for studying the role of Cyp2c genes and of CYP2C9 in particular in drug disposition and as a factor in drug-drug interaction.},
  language  = {en}
}
@article{LaumannMainz2012,
  author    = {Laumann, J{\"o}rg and Mainz, Stefan},
  title     = {Direkte Ermittlung der erforderlichen Einspanntiefe von I‑f{\"o}rmigen Stahlquerschnitten in Betonkonstruktionen},
  volume    = {81},
  number    = {11},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1437-1049},
  doi       = {10.1002/stab.201201620},
  pages     = {850 -- 860},
  year      = {2012},
  abstract  = {F{\"u}r die Ermittlung der erforderlichen Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen existieren verschiedene Bemessungsmodelle. Diese basieren vorwiegend auf Grundlage nationaler Normen wie z. B. DIN 18800 [1] und DIN 1045 [2], die durch die europ{\"a}ische Normung ersetzt wurden. Aus diesem Grund wird in diesem Aufsatz ein Berechnungsmodell f{\"u}r die erforderliche Einspanntiefe von eingespannten Stahlquerschnitten in Betonkonstruktionen auf Grundlage des Eurocodes vorgestellt. Das Grundger{\"u}st f{\"u}r dieses Berechnungsmodell bildet das Verfahren nach Kindmann und Laumann, welches in [3] behandelt wurde. Gleichzeitig werden neue Formeln zur direkten Ermittlung der Mindesteinspanntiefe vorgestellt. Behandelt werden gewalzte I-Profile f{\"u}r einachsige Biegung um die starke Achse (y-y) mit Drucknormalkraft.},
  language  = {de}
}