@inproceedings{DachwaldWurm2009, author = {Dachwald, Bernd and Wurm, P.}, title = {Design concept and modeling of an advanced solar photon thruster}, series = {Advances in the Astronautical Sciences}, booktitle = {Advances in the Astronautical Sciences}, publisher = {American Astronautical Society}, address = {San Diego, Calif.}, isbn = {978-087703554-1}, issn = {00653438}, pages = {723 -- 740}, year = {2009}, abstract = {The so-called "compound solar sail", also known as "Solar Photon Thruster" (SPT), holds the potential of providing significant performance advantages over the flat solar sail. Previous SPT design concepts, however, do not consider shadowing effects and multiple reflections of highly concentrated solar radiation that would inevitably destroy the gossamer sail film. In this paper, we propose a novel advanced SPT (ASPT) design concept that does not suffer from these oversimplifications. We present the equations that describe the thrust force acting on such a sail system and compare its performance with respect to the conventional flat solar sail.}, language = {en} } @inproceedings{DachwaldWurm2009, author = {Dachwald, Bernd and Wurm, P.}, title = {Mission analysis for an advanced solar photon thruster}, series = {60th International Astronautical Congress 2009, IAC 2009}, volume = {8}, booktitle = {60th International Astronautical Congress 2009, IAC 2009}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {978-161567908-9}, pages = {6838 -- 6851}, year = {2009}, abstract = {The so-called "compound solar sail", also known as "Solar Photon Thruster" (SPT), is a solar sail design concept, for which the two basic functions of the solar sail, namely light collection and thrust direction, are uncoupled. In this paper, we introduce a novel SPT concept, termed the Advanced Solar Photon Thruster (ASPT). This model does not suffer from the simplified assumptions that have been made for the analysis of compound solar sails in previous studies. We present the equations that describe the force, which acts on the ASPT. After a detailed design analysis, the performance of the ASPT with respect to the conventional flat solar sail (FSS) is investigated for three interplanetary mission scenarios: An Earth-Venus rendezvous, where the solar sail has to spiral towards the Sun, an Earth-Mars rendezvous, where the solar sail has to spiral away from the Sun, and an Earth-NEA rendezvous (to near-Earth asteroid 1996FG3), where a large orbital eccentricity change is required. The investigated solar sails have realistic near-term characteristic accelerations between 0.1 and 0.2mm/s2. Our results show that a SPT is not superior to the flat solar sail unless very idealistic assumptions are made.}, language = {en} } @article{DachwaldWurm2011, author = {Dachwald, Bernd and Wurm, Patrick}, title = {Mission analysis and performance comparison for an Advanced Solar Photon Thruster}, series = {Advances in Space Research}, volume = {48}, journal = {Advances in Space Research}, number = {11}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0273-1177}, pages = {1858 -- 1868}, year = {2011}, language = {en} } @inproceedings{DachwaldXuFeldmannetal.2011, author = {Dachwald, Bernd and Xu, Changsheng and Feldmann, Marco and Plescher, Engelbert}, title = {IceMole : Development of a novel subsurface ice probe and testing of the first prototype on the Morteratsch Glacier}, series = {EGU General Assembly 2011 Vienna | Austria | 03 - 08 April 2011}, booktitle = {EGU General Assembly 2011 Vienna | Austria | 03 - 08 April 2011}, year = {2011}, abstract = {We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).}, language = {en} } @inproceedings{DachwaldXuFeldmannetal.2011, author = {Dachwald, Bernd and Xu, Changsheng and Feldmann, Marco and Plescher, Engelbert and Digel, Ilya and Artmann, Gerhard}, title = {Development and testing of a subsurface probe for detection of life in deep ice : [abstract]}, year = {2011}, abstract = {We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth).}, subject = {Eisschicht}, language = {en} } @article{DadfarCamozziDarguzyteetal.2020, author = {Dadfar, Dryed Mohammadali and Camozzi, Denise and Darguzyte, Milita and Roemhild, Karolin and Varvar{\`a}, Paola and Metselaar, Josbert and Banala, Srinivas and Straub, Marcel and G{\"u}ver, Nihan and Engelmann, Ulrich M. and Slabu, Ioana and Buhl, Miriam and Leusen, Jan van and K{\"o}gerler, Paul and Hermanns-Sachweh, Benita and Schulz, Volkmar and Kiessling, Fabian and Lammers, Twan}, title = {Size-isolation of superparamagnetic iron oxide nanoparticles improves MRI, MPI and hyperthermia performance}, series = {Journal of Nanobiotechnology}, volume = {18}, journal = {Journal of Nanobiotechnology}, number = {Article number 22}, publisher = {Nature Portfolio}, issn = {1477-3155}, doi = {10.1186/s12951-020-0580-1}, pages = {1 -- 13}, year = {2020}, abstract = {Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized using the routinely employed co-precipitation technique. Transmission electron microscopy, dynamic light scattering and nanoparticle tracking analyses show that the SPION fractions obtained upon size-isolation are well-defined and almost monodisperse. MRI, MPI and MFH analyses demonstrate improved imaging and hyperthermia performance for size-isolated SPION as compared to the polydisperse starting mixture, as well as to commercial and clinically used iron oxide nanoparticle formulations, such as Resovist® and Sinerem®. The size-isolation protocol presented here may help to identify SPION with optimal properties for diagnostic, therapeutic and theranostic applications.}, language = {en} } @article{DahlSuttrop1998, author = {Dahl, G{\"u}nter and Suttrop, F.}, title = {Engine control and low-NO(x) combustion for hydrogen fuelled aircraft gas turbines}, series = {International Journal of Hydrogen Energy. 23 (1998), H. 8}, journal = {International Journal of Hydrogen Energy. 23 (1998), H. 8}, isbn = {0360-3199}, pages = {695 -- 704}, year = {1998}, language = {en} } @inproceedings{DalguerChurilovButenwegetal.2014, author = {Dalguer, Luis A. and Churilov, Sergey and Butenweg, Christoph and Renault, Philippe and Hyun, An Jun}, title = {Dynamic analysis of a reinforced concrete electrical nuclear building of SMART 2013 project subjected to earthquake excitation using ABAQUS}, series = {Workshop SMART2013 : Paris, France, November 25th - 27th, 2014}, booktitle = {Workshop SMART2013 : Paris, France, November 25th - 27th, 2014}, organization = {Workshop SMART2013 <2014, Paris>}, pages = {1 -- 12}, year = {2014}, language = {en} } @inproceedings{DalguerRenaultChurilovetal.2016, author = {Dalguer, Luis A. and Renault, Philippe and Churilov, Sergey and Butenweg, Christoph}, title = {Evaluation of fragility curves for a three-storey-reinforced-concrete mock-up of SMART 2013 project}, series = {Transactions, SMiRT-23 : 23rd Conference on Structural Mechanics in Reactor Technology : Manchester, United Kingdom - August 10-14, 2015}, booktitle = {Transactions, SMiRT-23 : 23rd Conference on Structural Mechanics in Reactor Technology : Manchester, United Kingdom - August 10-14, 2015}, organization = {Conference on Structural Mechanics in Reactor Technology <23, 2015, Manchester>}, pages = {1 -- 9}, year = {2016}, language = {en} } @article{DallasSalphatiGomezZepedaetal.2016, author = {Dallas, Shannon and Salphati, Laurent and Gomez-Zepeda, David and Wanek, Thomas and Chen, Liangfu and Chu, Xiaoyan and Kunta, Jeevan and Mezler, Mario and Menet, Marie-Claude and Chasseigneaux, Stephanie and Decl{\`e}ves, Xavier and Langer, Oliver and Pierre, Esaie and DiLoreto, Karen and Hoft, Carolin and Laplanche, Loic and Pang, Jodie and Pereira, Tony and Andonian, Clara and Simic, Damir and Rode, Anja and Yabut, Jocelyn and Zhang, Xiaolin and Scheer, Nico}, title = {Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model}, series = {Molecular Pharmacology}, volume = {89}, journal = {Molecular Pharmacology}, number = {5}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.115.102079}, pages = {492 -- 504}, year = {2016}, abstract = {Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby BCRP acts as an efflux pump, mediating the elimination or restricting the entry of endogenous compounds or xenobiotics into tissues and it plays important roles in drug disposition, efficacy and safety. Bcrp knockout mice (Bcrp-/-) have been used widely to study the role of this transporter in limiting intestinal absorption and brain penetration of substrate compounds. Here we describe the first generation and characterization of a mouse line humanized for BCRP (hBCRP), in which the mouse coding sequence from the start to stop codon was replaced with the corresponding human genomic region, such that the human transporter is expressed under control of the murine Bcrp promoter. We demonstrate robust human and loss of mouse BCRP/Bcrp mRNA and protein expression in the hBCRP mice and the absence of major compensatory changes in the expression of other genes involved in drug metabolism and disposition. Pharmacokinetic and brain distribution studies with several BCRP probe substrates confirmed the functional activity of the human transporter in these mice. Furthermore, we provide practical examples for the use of hBCRP mice to study drug-drug interactions (DDIs). The hBCRP mouse is a promising model to study the in vivo role of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate clinically relevant DDIs involving BCRP.}, language = {en} } @article{DammErlerHillenetal.2011, author = {Damm, Alexander and Erler, Andr{\´e} and Hillen, Walter and Meroni, Michele and Schaepman, Michael E. and Verhoef, Wout and Rascher, Uwe}, title = {Modeling the impact of spectral sensor configurations on the FLD retrieval accuracy of sun-induced chlorophyll fluorescence}, series = {Remote Sensing of Environment}, volume = {115}, journal = {Remote Sensing of Environment}, number = {8}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {0034-4257}, pages = {1882 -- 1892}, year = {2011}, language = {en} } @article{DammSauerbornFendetal.2017, author = {Damm, Marc Andr{\´e} and Sauerborn, Markus and Fend, Thomas and Herrmann, Ulf}, title = {Optimisation of a urea selective catalytic reduction system with a coated ceramic mixing element}, series = {Journal of ceramic science and technology}, volume = {8}, journal = {Journal of ceramic science and technology}, number = {1}, publisher = {G{\"o}ller}, address = {Baden-Baden}, isbn = {2190-9385 (Print)}, issn = {2190-9385 (Online)}, doi = {10.4416/JCST2016-00056}, pages = {19 -- 24}, year = {2017}, language = {en} } @inproceedings{DammRahierRitzetal.2013, author = {Damm, Sebastian and Rahier, Michael and Ritz, Thomas and Sch{\"a}fer, Thomas}, title = {Architecture for platform- and hardware-independent mesh networks : how to unify the channels}, series = {ICSNC 2013 : The Eighth International Conference on Systems and Networks Communications ; October 27, 2013 to October 31, 2013, Venice Italy}, booktitle = {ICSNC 2013 : The Eighth International Conference on Systems and Networks Communications ; October 27, 2013 to October 31, 2013, Venice Italy}, editor = {Davoli, Renzo}, publisher = {Curran Associates}, address = {Red Hook, NY}, isbn = {978-1-61208-305-6}, pages = {131 -- 134}, year = {2013}, abstract = {This paper will prove that mesh networks among different platforms and hardware channels can help to channel valuable information even if public telecommunication infrastructure is not available due to arbitrary reasons. Therefore, results of a simulation for mesh networks on mass events will be provided, followed by the developed architecture and an outlook on future research. The developed architecture is currently being implemented and field tested on mass events.}, language = {en} } @inproceedings{DammRitzStrauch2011, author = {Damm, Sebastian and Ritz, Thomas and Strauch, Jakob}, title = {Adaption of archetype patterns for mobile cloud-based business apps}, series = {2011 IEEE International Conference on Pervasive Computing and Communications workshops (PerCom workshops 2011) : Seattle, Washington, USA, 21 - 25 March 2011}, booktitle = {2011 IEEE International Conference on Pervasive Computing and Communications workshops (PerCom workshops 2011) : Seattle, Washington, USA, 21 - 25 March 2011}, publisher = {IEEE Service Center}, address = {Piscataway, NJ}, isbn = {978-1-61284-938-6 (Print)}, doi = {10.1109/PERCOMW.2011.5766849}, pages = {100 -- 105}, year = {2011}, language = {en} } @article{Damrau1999, author = {Damrau, Karin}, title = {Beyond Solidity - Inventions, Spaces and Concepts for the Elements of Air and Water}, series = {Architectural design : AD. 69 (1999), H. 3-4}, journal = {Architectural design : AD. 69 (1999), H. 3-4}, isbn = {0003-8504}, pages = {22 -- 33}, year = {1999}, language = {en} } @article{Damrau2000, author = {Damrau, Karin}, title = {Fantastic Spatial Combinations in Film}, series = {Architectural design : AD. 70 (2000), H. 1}, journal = {Architectural design : AD. 70 (2000), H. 1}, isbn = {0003-8504}, pages = {58 -- 61}, year = {2000}, language = {en} } @article{DanhoNaithaniSasakietal.1980, author = {Danho, Waleed and Naithani, Vinod K. and Sasaki, Andr{\´e} N. and F{\"o}hles, Joseph and Berndt, Heinz and B{\"u}llesbach, Erika E. and Zahn, H.}, title = {Human proinsulin, VII : synthesis of two protected peptides corresponding to the sequences 1—45 and 46—86 of the prohormone}, series = {Hoppe-Seyler's Zeitschrift f{\"u}r physiologische Chemie}, volume = {361}, journal = {Hoppe-Seyler's Zeitschrift f{\"u}r physiologische Chemie}, number = {1}, issn = {1437-4315}, doi = {10.1515/bchm2.1980.361.1.857}, pages = {857 -- 863}, year = {1980}, language = {en} } @article{DankelmannHellwigVolkmann2009, author = {Dankelmann, Peter and Hellwig, Angelika and Volkmann, Lutz}, title = {Inverse degree and edge-connectivity}, series = {Discrete mathematics}, volume = {Vol. 309}, journal = {Discrete mathematics}, number = {Iss. 9}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-681X (E-Journal); 0012-365X (Print)}, pages = {2943 -- 2947}, year = {2009}, language = {en} } @article{DankelmannHellwigVolkmann2007, author = {Dankelmann, Peter and Hellwig, Angelika and Volkmann, Lutz}, title = {On the connectivity of diamond-free graphs}, series = {Discrete applied mathematics}, volume = {Vol. 155}, journal = {Discrete applied mathematics}, number = {Iss. 16}, issn = {0166-218X (E-Journal); 1872-6771 (E-Journal); 0166-218X (Print)}, pages = {2111 -- 2117}, year = {2007}, language = {en} } @inproceedings{DannenSchindelePruemmeretal.2022, author = {Dannen, Tammo and Schindele, Benedikt and Pr{\"u}mmer, Marcel and Arntz, Kristian and Bergs, Thomas}, title = {Methodology for the self-optimizing determination of additive manufacturing process eligibility and optimization potentials in toolmaking}, series = {Procedia CIRP Leading manufacturing systems transformation - Proceedings of the 55th CIRP Conference on Manufacturing Systems 2022}, volume = {107}, booktitle = {Procedia CIRP Leading manufacturing systems transformation - Proceedings of the 55th CIRP Conference on Manufacturing Systems 2022}, publisher = {Elsevier}, address = {Amsterdam}, issn = {2212-8271}, doi = {10.1016/j.procir.2022.05.188}, pages = {1539 -- 1544}, year = {2022}, abstract = {Additive Manufacturing (AM) of metallic workpieces faces a continuously rising technological relevance and market size. Producing complex or highly strained unique workpieces is a significant field of application, making AM highly relevant for tool components. Its successful economic application requires systematic workpiece based decisions and optimizations. Considering geometric and technological requirements as well as the necessary post-processing makes deciding effortful and requires in-depth knowledge. As design is usually adjusted to established manufacturing, associated technological and strategic potentials are often neglected. To embed AM in a future proof industrial environment, software-based self-learning tools are necessary. Integrated into production planning, they enable companies to unlock the potentials of AM efficiently. This paper presents an appropriate methodology for the analysis of process-specific AM-eligibility and optimization potential, added up by concrete optimization proposals. For an integrated workpiece characterization, proven methods are enlarged by tooling-specific figures. The first stage of the approach specifies the model's initialization. A learning set of tooling components is described using the developed key figure system. Based on this, a set of applicable rules for workpiece-specific result determination is generated through clustering and expert evaluation. Within the following application stage, strategic orientation is quantified and workpieces of interest are described using the developed key figures. Subsequently, the retrieved information is used for automatically generating specific recommendations relying on the generated ruleset of stage one. Finally, actual experiences regarding the recommendations are gathered within stage three. Statistic learning transfers those to the generated ruleset leading to a continuously deepening knowledge base. This process enables a steady improvement in output quality.}, language = {en} } @article{DantismTakenagaWagneretal.2015, author = {Dantism, S. and Takenaga, S. and Wagner, P. and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Light-addressable Potentiometric Sensor (LAPS) Combined with Multi-chamber Structures to Investigate the Metabolic Activity of Cells}, series = {Procedia Engineering}, volume = {120}, journal = {Procedia Engineering}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1877-7058}, doi = {10.1016/j.proeng.2015.08.647}, pages = {384 -- 387}, year = {2015}, abstract = {LAPS are field-effect-based potentiometric sensors which are able to monitor analyte concentrations in a spatially resolved manner. Hence, a LAPS sensor system is a powerful device to record chemical imaging of the concentration of chemical species in an aqueous solution, chemical reactions, or the growth of cell colonies on the sensor surface, to record chemical images. In this work, multi-chamber 3D-printed structures made out of polymer (PP-ABS) were combined with LAPS chips to analyse differentially and simultaneously the metabolic activity of Escherichia coli K12 and Chinese hamster ovary (CHO) cells, and the responds of those cells to the addition of glucose solution.}, language = {en} } @article{DantismRoehlenDahmenetal.2020, author = {Dantism, Shahriar and R{\"o}hlen, Desiree and Dahmen, Markus and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {LAPS-based monitoring of metabolic responses of bacterial cultures in a paper fermentation broth}, series = {Sensors and Actuators B: Chemical}, volume = {320}, journal = {Sensors and Actuators B: Chemical}, number = {Art. 128232}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2020.128232}, year = {2020}, abstract = {As an alternative renewable energy source, methane production in biogas plants is gaining more and more attention. Biomass in a bioreactor contains different types of microorganisms, which should be considered in terms of process-stability control. Metabolically inactive microorganisms within the fermentation process can lead to undesirable, time-consuming and cost-intensive interventions. Hence, monitoring of the cellular metabolism of bacterial populations in a fermentation broth is crucial to improve the biogas production, operation efficiency, and sustainability. In this work, the extracellular acidification of bacteria in a paper-fermentation broth is monitored after glucose uptake, utilizing a differential light-addressable potentiometric sensor (LAPS) system. The LAPS system is loaded with three different model microorganisms (Escherichia coli, Corynebacterium glutamicum, and Lactobacillus brevis) and the effect of the fermentation broth at different process stages on the metabolism of these bacteria is studied. In this way, different signal patterns related to the metabolic response of microorganisms can be identified. By means of calibration curves after glucose uptake, the overall extracellular acidification of bacterial populations within the fermentation process can be evaluated.}, language = {en} } @article{DantismRoehlenSelmeretal.2019, author = {Dantism, Shahriar and R{\"o}hlen, Desiree and Selmer, Thorsten and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system}, series = {Biosensors and Bioelectronics}, volume = {139}, journal = {Biosensors and Bioelectronics}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.bios.2019.111332}, pages = {Artikel 111332}, year = {2019}, language = {en} } @article{DantismRoehlenWagneretal.2019, author = {Dantism, Shahriar and R{\"o}hlen, Desiree and Wagner, Torsten and Wagner, P. and Sch{\"o}ning, Michael Josef}, title = {A LAPS-based differential sensor for parallelized metabolism monitoring of various bacteria}, series = {Sensors}, volume = {19}, journal = {Sensors}, number = {21}, publisher = {MDPI}, address = {Basel}, issn = {1424-8220}, doi = {10.3390/s19214692}, pages = {Artikel 4692}, year = {2019}, abstract = {Monitoring the cellular metabolism of bacteria in (bio)fermentation processes is crucial to control and steer them, and to prevent undesired disturbances linked to metabolically inactive microorganisms. In this context, cell-based biosensors can play an important role to improve the quality and increase the yield of such processes. This work describes the simultaneous analysis of the metabolic behavior of three different types of bacteria by means of a differential light-addressable potentiometric sensor (LAPS) set-up. The study includes Lactobacillus brevis, Corynebacterium glutamicum, and Escherichia coli, which are often applied in fermentation processes in bioreactors. Differential measurements were carried out to compensate undesirable influences such as sensor signal drift, and pH value variation during the measurements. Furthermore, calibration curves of the cellular metabolism were established as a function of the glucose concentration or cell number variation with all three model microorganisms. In this context, simultaneous (bio)sensing with the multi-organism LAPS-based set-up can open new possibilities for a cost-effective, rapid detection of the extracellular acidification of bacteria on a single sensor chip. It can be applied to evaluate the metabolic response of bacteria populations in a (bio)fermentation process, for instance, in the biogas fermentation process.}, language = {en} } @article{DantismRoehlenWagneretal.2018, author = {Dantism, Shahriar and R{\"o}hlen, Desiree and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Optimization of Cell-Based Multi-Chamber LAPS Measurements Utilizing FPGA-Controlled Laser-Diode Modules}, series = {physica status solidi a : applications and materials sciences}, volume = {215}, journal = {physica status solidi a : applications and materials sciences}, number = {15}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201800058}, pages = {Article number 1800058}, year = {2018}, abstract = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric device, which detects concentration changes of an analyte solution on the sensor surface in a spatially resolved way. It uses a light source to generate electron-hole pairs inside the semiconductor, which are separated in the depletion region due to an applied bias voltage across the sensor structure and hence, a surface-potential-dependent photocurrent can be read out. However, depending on the beam angle of the light source, scattering effects can occur, which influence the recorded signal in LAPS-based differential measurements. To solve this problem, a novel illumination unit based on a field programmable gate array (FPGA) consisting of 16 small-sized tunable infrared laser-diode modules (LDMs) is developed. Due to the improved focus of the LDMs with a beam angle of only 2 mrad, undesirable scattering effects are minimized. Escherichia coli (E. coli) K12 bacteria are used as a test microorganism to study the extracellular acidification on the sensor surface. Furthermore, a salt bridge chamber is built up and integrated with the LAPS system enabling multi-chamber differential measurements with a single Ag/AgCl reference electrode.}, language = {en} } @article{DantismTakenagaWagneretal.2016, author = {Dantism, Shahriar and Takenaga, Shoko and Wagner, Patrick and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system}, series = {Physica status solidi (a)}, volume = {213}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.201533043}, pages = {1479 -- 1485}, year = {2016}, abstract = {On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable "down times" during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements.}, language = {en} } @article{DantismTakenagaWagneretal.2017, author = {Dantism, Shahriar and Takenaga, Shoko and Wagner, Torsten and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Differential imaging of the metabolism of bacteria and eukaryotic cells based on light-addressable potentiometric sensors}, series = {Electrochimica Acta}, volume = {246}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2017.05.196}, pages = {234 -- 241}, year = {2017}, abstract = {A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric sensor with an electrolyte/insulator/semiconductor (EIS) structure, which is able to monitor analyte concentrations of (bio-)chemical species in aqueous solutions in a spatially resolved way. Therefore, it is also an appropriate tool to record 2D-chemical images of concentration variations on the sensor surface. In the present work, two differential, LAPS-based measurement principles are introduced to determine the metabolic activity of Escherichia coli (E. coli) K12 and Chinese hamster ovary (CHO) cells as test microorganisms. Hereby, we focus on i) the determination of the extracellular acidification rate (ΔpH/min) after adding glucose solutions to the cell suspensions; and ii) recording the amplitude increase of the photocurrent (Iph) related to the produced acids from E. coli K12 bacteria and CHO cells on the sensor surface by 2D-chemical imaging. For this purpose, 3D-printed multi-chamber structures were developed and mounted on the planar sensor-chip surface to define four independent compartments, enabling differential measurements with varying cell concentrations. The differential concept allows eliminating unwanted drift effects and, with the four-chamber structures, measurements on the different cell concentrations were performed simultaneously, thus reducing also the overall measuring time.}, language = {en} } @article{DarmoSchaefferFoersteretal.2000, author = {Darmo, J. and Sch{\"a}ffer, F. and F{\"o}rster, Arnold and Kordos, P.}, title = {Beryllium doped low-temperature-grown MBE GaAs: material for photomixing in the THz frequency range}, series = {ASDAM 2000 : conference proceedings / edited by Jozef Osvald ... [et al.]}, journal = {ASDAM 2000 : conference proceedings / edited by Jozef Osvald ... [et al.]}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {0780359399}, pages = {147 -- 150}, year = {2000}, language = {en} } @inproceedings{DarvenizaFlisowskiKernetal.2002, author = {Darveniza, M. and Flisowski, Z. and Kern, Alexander and Landers, E.-U. and LoPiparo, G. and Mazzetti, C. and Rousseau, A. and Sherlock, J.}, title = {Application problems of the probabilistic approach to the assessment of risk for structures and services}, year = {2002}, abstract = {The paper deals with the development of the probabilistic approach to the assessment of risk due to lightning. Sources of damage, types of damage and types of loss are defined and, accordingly, the procedure for risk analysis and the way of assessment of different risk components is proposed. The way to evaluate the influence of different protection measures (lightning protection system; shielding of structure, cables and equipment; routing of internal wiring; surge protective device) in reducing such probabilities is considered. The paper has been prepared within the framework of the activity of IEC TC81-WG9/CLC TC81-WG4 directed to prepare the draft IEC 62305-2 Risk Management, in cooperation with the Secretary of IEC/CLC TC81.}, language = {en} } @article{DashevskyLanzlKotliar2011, author = {Dashevsky, Alexey V. and Lanzl, Ines M. and Kotliar, Konstantin}, title = {Non-penetrating intracanalicular partial trabeculectomy via the ostia of Schlemm's canal}, series = {Graefe's Archive for Clinical and Experimental Ophthalmology}, volume = {249}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {0721-832x}, pages = {565 -- 573}, year = {2011}, language = {en} } @article{deBloisdeZangerPaulssenetal.2018, author = {de Blois, Eric and de Zanger, Rory M. S. and Paulßen, Elisabeth and Sze Chan, Ho and Breeman, Wouter A. P.}, title = {Semi-automated system for concentrating 68Ga-eluate to obtain high molar and volume concentration of 68Ga-Radiopharmaca for preclinical applications}, series = {Nuclear Medicine and Biology}, volume = {64-65}, journal = {Nuclear Medicine and Biology}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.nucmedbio.2018.06.006}, pages = {16 -- 21}, year = {2018}, abstract = {68Ga-radiopharmaceuticals are common in the field of Nuclear Medicine to visualize receptor-mediated processes. In contrast to straightforward labeling procedures for clinical applications, preclinical in vitro and in vivo applications are hampered for reasons like e.g. volume restriction, activity concentration, molar activity and osmolality. Therefore, we developed a semiautomatic system specifically to overcome these problems. A difficulty appeared unexpectedly, as intrinsic trace metals derived from eluate (Zn, Fe and Cu) are concentrated as well in amounts that influence radiochemical yield and thus lower molar activity.}, language = {en} } @inproceedings{deHondePorstDigel2017, author = {de Honde, Lukas and Porst, Dariusz and Digel, Ilya}, title = {A randomized, observational thermographic study of the neck region before and after a physiotherapeutic intervention}, series = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, booktitle = {2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West}, editor = {Fischerauer, Alice}, publisher = {Universit{\"a}t Duisburg-Essen}, address = {Duisburg}, organization = {MedTech Symposium}, isbn = {978-3-9814801-9-1}, doi = {10.17185/duepublico/43984}, pages = {122 -- 123}, year = {2017}, language = {en} } @article{DefosseKleinschmidtSchmutzetal.2022, author = {Defosse, Jerome and Kleinschmidt, Joris and Schmutz, Axel and Loop, Torsten and Staat, Manfred and Gatzweiler, Karl-Heinz and Wappler, Frank and Schieren, Mark}, title = {Dental strain on maxillary incisors during tracheal intubation with double-lumen tubes and different laryngoscopy techniques - a blinded manikin study}, series = {Journal of Cardiothoracic and Vascular Anesthesia}, volume = {36}, journal = {Journal of Cardiothoracic and Vascular Anesthesia}, number = {8, Part B}, publisher = {Elsevier}, address = {New York, NY}, issn = {1053-0770}, doi = {10.1053/j.jvca.2022.02.017}, pages = {3021 -- 3027}, year = {2022}, language = {en} } @article{DegeringEggertPulsetal.2010, author = {Degering, Christian and Eggert, Thorsten and Puls, Michael and Bongaerts, Johannes and Evers, Stefan and Maurer, Karl-Heinz and Jaeger, Karl-Erich}, title = {Optimization of protease secretion in Bacillus subtilis and Bacillus licheniformis by screening of homologous and herologous signal peptides}, series = {Applied and environmental microbiology}, volume = {76}, journal = {Applied and environmental microbiology}, number = {19}, publisher = {American Society for Microbiology}, address = {Washington, DC}, issn = {1098-5336 (E-Journal); 0003-6919 (Print); 0099-2240 (Print)}, doi = {10.1128/AEM.01146-10}, pages = {6370 -- 6378}, year = {2010}, abstract = {Bacillus subtilis and Bacillus licheniformis are widely used for the large-scale industrial production of proteins. These strains can efficiently secrete proteins into the culture medium using the general secretion (Sec) pathway. A characteristic feature of all secreted proteins is their N-terminal signal peptides, which are recognized by the secretion machinery. Here, we have studied the production of an industrially important secreted protease, namely, subtilisin BPN′ from Bacillus amyloliquefaciens. One hundred seventy-three signal peptides originating from B. subtilis and 220 signal peptides from the B. licheniformis type strain were fused to this secretion target and expressed in B. subtilis, and the resulting library was analyzed by high-throughput screening for extracellular proteolytic activity. We have identified a number of signal peptides originating from both organisms which produced significantly increased yield of the secreted protease. Interestingly, we observed that levels of extracellular protease were improved not only in B. subtilis, which was used as the screening host, but also in two different B. licheniformis strains. To date, it is impossible to predict which signal peptide will result in better secretion and thus an improved yield of a given extracellular target protein. Our data show that screening a library consisting of homologous and heterologous signal peptides fused to a target protein can identify more-effective signal peptides, resulting in improved protein export not only in the original screening host but also in different production strains.}, language = {en} } @article{Delaittre2019, author = {Delaittre, Guillaume}, title = {Telechelic Poly(2-Oxazoline)s}, series = {European Polymer Journal}, journal = {European Polymer Journal}, number = {In Press, Journal Pre-proof, 109281}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0014-3057}, doi = {10.1016/j.eurpolymj.2019.109281}, year = {2019}, language = {en} } @article{DelleHuckBaeckeretal.2015, author = {Delle, Lotta E. and Huck, Christina and B{\"a}cker, Matthias and M{\"u}ller, Frank and Grandthyll, Samuel and Jacobs, Karin and Lilischkis, Rainer and Vu, Xuan T. and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Thoelen, Roland and Weil, Maryam and Ingebrandt, Sven}, title = {Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431863}, pages = {1327 -- 1334}, year = {2015}, language = {en} } @article{DellmannGloriusLitvinovetal.2023, author = {Dellmann, Sophia Florence and Glorius, J. and Litvinov, Yu A. and Reifarth, R. and Al-Khasawneh, Kafa and Aliotta, M. and Bott, L. and Br{\"u}ckner, Benjamin and Bruno, C. G. and Chen, Ruijiu and Davinson, T. and Dickel, T. and Dillmann, Iris and Dmytriev, D. and Erbacher, P. and Freire-Fern{\´a}ndez, D. and Forstner, Oliver and Geissel, H. and G{\"o}bel, K. and Griffin, Christopher J. and Grisenti, R. and Gumberidze, Alexandre and Haettner, Emma and Hagmann, Siegbert and Heil, M. and Heß, R. and Hillenbrand, P.-M. and Joseph, R. and Jurado, B. and Kozhuharov, Christophor and Kulikov, I. and L{\"o}her, Bastian and Langer, Christoph and Leckenby, Guy and Lederer-Woods, C. and Lestinsky, M. and Litvinov, S. A. and Lorenz, B. A. and Lorenz, E. and Marsh, J. and Menz, Esther Babette and Morgenroth, T. and Petridis, N. and Pibernat, Jerome and Popp, U. and Psaltis, Athanasios and Sanjari, Shahab and Scheidenberger, C. and Sguazzin, M. and Sidhu, Ragandeep Singh and Spillmann, Uwe and Steck, M. and St{\"o}hlker, T. and Surzhykov, A. and Swartz, J. A. and T{\"o}rnqvist, H. and Varga, L. and Vescovi, Diego and Weick, H. and Weigand, M. and Woods, P. and Xing, Y. and Yamaguchi, Taiyo}, title = {Proton capture on stored radioactive ¹¹⁸Te ions}, series = {EPJ Web of Conferences}, volume = {279}, journal = {EPJ Web of Conferences}, number = {Article Number: 11018}, publisher = {EDP Sciences}, issn = {2100-014X}, doi = {10.1051/epjconf/202327911018}, pages = {1 -- 5}, year = {2023}, abstract = {Experimental determination of the cross sections of proton capture on radioactive nuclei is extremely difficult. Therefore, it is of substantial interest for the understanding of the production of the p-nuclei. For the first time, a direct measurement of proton-capture cross sections on stored, radioactive ions became possible in an energy range of interest for nuclear astrophysics. The experiment was performed at the Experimental Storage Ring (ESR) at GSI by making use of a sensitive method to measure (p,γ) and (p,n) reactions in inverse kinematics. These reaction channels are of high relevance for the nucleosyn-thesis processes in supernovae, which are among the most violent explosions in the universe and are not yet well understood. The cross section of the ¹¹⁸Te(p,γ) reaction has been measured at energies of 6 MeV/u and 7 MeV/u. The heavy ions interacted with a hydrogen gas jet target. The radiative recombination process of the fully stripped ¹¹⁸Te ions and electrons from the hydrogen target was used as a luminosity monitor. An overview of the experimental method and preliminary results from the ongoing analysis will be presented.}, language = {en} } @article{DemirciTrzewikLinderetal.2004, author = {Demirci, T. and Trzewik, J. and Linder, Peter and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison}, series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1046 -- 1047}, year = {2004}, language = {en} } @article{DemirciTrzewikLinderetal.2004, author = {Demirci, T. and Trzewik, J. and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l}, title = {Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level}, series = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, journal = {Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2}, isbn = {0932-4666}, pages = {1030 -- 1031}, year = {2004}, language = {en} } @article{DemirciKurulganDemirciTrzewiketal.2009, author = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l}, title = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress}, series = {IUBMB Life. 61 (2009), H. 3}, journal = {IUBMB Life. 61 (2009), H. 3}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {1521-6543}, pages = {311 -- 312}, year = {2009}, language = {en} } @article{DemmerChowdhurySelmeretal.2017, author = {Demmer, Julius K. and Chowdhury, Nilanjan Pal and Selmer, Thorsten and Ermler, Ulrich and Buckel, Wolfgang}, title = {The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile}, series = {Nature Communications}, volume = {8}, journal = {Nature Communications}, number = {1}, issn = {2041-1723}, doi = {10.1038/s41467-017-01746-3}, pages = {1 -- 10}, year = {2017}, language = {en} } @article{DeppeBongaertsO'Connelletal.2011, author = {Deppe, Veronika Maria and Bongaerts, Johannes and O'Connell, Timothy and Maurer, Karl-Heinz and Meinhardt, Friedhelm}, title = {Enzymatic deglycation of Amadori products in bacteria}, series = {Applied microbiology and biotechnology}, volume = {Vol. 90}, journal = {Applied microbiology and biotechnology}, number = {Iss. 2}, publisher = {Springer}, address = {Berlin}, issn = {1432-0614 (E-Journal); 0171-1741 (Print); 0175-7598 (Print); 0340-2118 (Print)}, pages = {399 -- 406}, year = {2011}, language = {en} } @article{DeppeKlatteBongaertsetal.2011, author = {Deppe, Veronika Maria and Klatte, Stephanie and Bongaerts, Johannes and Maurer, Karl-Heinz and O'Connell, Timothy and Meinhardt, Friedhelm}, title = {Genetic control of Amadori product degradation in Bacillus subtilis via regulation of frlBONMD expression by FrlR}, series = {Applied and environmental microbiology}, volume = {Vol. 77}, journal = {Applied and environmental microbiology}, number = {No. 9}, publisher = {American Society of Mechanical Engineers (ASME)}, address = {New York}, issn = {1098-5336 (E-Journal); 0003-6919 (Print); 0099-2240 (Print)}, pages = {2839 -- 2846}, year = {2011}, language = {en} } @article{DerschGeyerHerrmannetal.2004, author = {Dersch, J{\"u}rgen and Geyer, Michael and Herrmann, Ulf and Jones, Scott A. and Kelly, Bruce and Kistner, Rainer and Ortmanns, Winfried and Pitz-Paal, Robert and Price, Henry}, title = {Trough integration into power plants—a study on the performance and economy of integrated solar combined cycle systems}, series = {Energy : the international journal}, volume = {29}, journal = {Energy : the international journal}, number = {5-6 (Special Issue SolarPaces)}, issn = {0360-5442}, doi = {10.1016/S0360-5442(03)00199-3}, pages = {947 -- 959}, year = {2004}, language = {en} } @inproceedings{DerschGeyerHerrmannetal.2002, author = {Dersch, J{\"u}rgen and Geyer, Michael and Herrmann, Ulf and Jones, Scott A. and Kelly, Bruce and Kistner, Rainer and Ortmanns, Winfried and Pitz-Paal, Robert and Price, Henry}, title = {Trough integration into power plants : a study on the performance and economy of integrated solar combined cycle systems}, series = {Proceedings of the 11th SolarPACES International Symposium on Concentrated Solar Power and Chemical Energy Technologies : September 4 - 6, 2002, Zurich, Switzerland / Paul Scherrer Institut, PSI; ETH, Eidgen{\"o}ssische Technische Hochschule Z{\"u}rich}, booktitle = {Proceedings of the 11th SolarPACES International Symposium on Concentrated Solar Power and Chemical Energy Technologies : September 4 - 6, 2002, Zurich, Switzerland / Paul Scherrer Institut, PSI; ETH, Eidgen{\"o}ssische Technische Hochschule Z{\"u}rich}, editor = {Steinfeld, Aldo}, publisher = {Paul Scherrer Inst.}, address = {Villingen}, isbn = {3-9521409-3-7}, pages = {661 -- 671}, year = {2002}, language = {en} } @inproceedings{DerschGeyerHerrmannetal.2002, author = {Dersch, J{\"u}rgen and Geyer, Michael and Herrmann, Ulf and Jones, Scott A. and Kelly, Bruce and Kistner, Rainer and Ortmanns, Winfried and Pitz-Paal, Robert and Price, Henry}, title = {Solar Trough Integration Into Combined Cycle Systems}, series = {Solar engineering 2002 : proceedings of the International Solar Energy Conference ; presented at the 2002 International Solar Energy Conference, a part of Solar 2002 - Sunrise on the Reliable Energy Economy, June 15 - 20, 2002, Reno, Nevada}, booktitle = {Solar engineering 2002 : proceedings of the International Solar Energy Conference ; presented at the 2002 International Solar Energy Conference, a part of Solar 2002 - Sunrise on the Reliable Energy Economy, June 15 - 20, 2002, Reno, Nevada}, editor = {Pearson, J. Boise}, publisher = {ASME}, isbn = {0-7918-1689-3}, doi = {doi:10.1115/SED2002-1072}, pages = {351 -- 359}, year = {2002}, language = {en} } @article{DesernoAachAmuntsetal.2011, author = {Deserno, Thomas M. and Aach, Til and Amunts, Katrin and Hillen, Walter and Kuhlen, Torsten and Scholl, Ingrid}, title = {Advances in medical image processing : A special Issue on the Workshop in Aachen, Germany, March 2010}, series = {Computer Science - Research and Development. 26 (2011), H. 1-2}, journal = {Computer Science - Research and Development. 26 (2011), H. 1-2}, publisher = {springer}, address = {Berlin}, isbn = {1865-2042}, pages = {1 -- 3}, year = {2011}, language = {en} } @inproceedings{DetertGligorevicHaaketal.2003, author = {Detert, T. and Gligorevic, Snjezana and Haak, W. and Sorger, Ulrich}, title = {Maximum-likelihood channel estimation using the spreading matrix in fast time-variant frequency selective channels}, series = {Proceedings of the 3rd IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2003 : 14 - 17 December 2003, Darmstadt, Germany}, booktitle = {Proceedings of the 3rd IEEE International Symposium on Signal Processing and Information Technology, ISSPIT 2003 : 14 - 17 December 2003, Darmstadt, Germany}, organization = {Institute of Electrical and Electronics Engineers}, isbn = {0-7803-8292-7}, pages = {347 -- 350}, year = {2003}, language = {en} } @article{DethloffKrollLudwigs2006, author = {Dethloff, Nina and Kroll-Ludwigs, Kathrin}, title = {The Constitutional Court as Driver of Reforms in German Family Law}, series = {International Survey of Family Law}, journal = {International Survey of Family Law}, pages = {217 -- 234}, year = {2006}, language = {en} } @article{DethloffKrollLudwigs2008, author = {Dethloff, Nina and Kroll-Ludwigs, Kathrin}, title = {Strengthening Children's Rights in German Family Law}, series = {The International Survey of Family Law}, journal = {The International Survey of Family Law}, pages = {119 -- 136}, year = {2008}, language = {en} }