@article{AlbrachtArampatzis2013,
  author    = {Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Exercise-induced changes in triceps surae tendon stiffness and muscle strength affect running economy in humans},
  series = {European Journal of Applied Physiology},
  volume    = {113},
  journal   = {European Journal of Applied Physiology},
  number    = {6},
  publisher = {Springer},
  address   = {Berlin},
  issn      = {1439-6327},
  doi       = {10.1007/s00421-012-2585-4},
  pages     = {1605 -- 1615},
  year      = {2013},
  language  = {en}
}
@article{KaramanidisAlbrachtBraunsteinetal.2011,
  author    = {Karamanidis, Kiros and Albracht, Kirsten and Braunstein, Bjoern and Catala, Maria Moreno and Goldmann, Jan-Peter and Br{\"u}ggemann, Gert-Peter},
  title     = {Lower leg musculoskeletal geometry and sprint performance},
  series = {Gait and Posture},
  volume    = {34},
  journal   = {Gait and Posture},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0966-6362},
  doi       = {10.1016/j.gaitpost.2011.03.009},
  pages     = {138 -- 141},
  year      = {2011},
  abstract  = {The purpose of this study was to investigate whether sprint performance is related to lower leg musculoskeletal geometry within a homogeneous group of highly trained 100-m sprinters. Using a cluster analysis, eighteen male sprinters were divided into two groups based on their personal best (fast: N = 11, 10.30 ± 0.07 s; slow: N = 7, 10.70 ± 0.08 s). Calf muscular fascicle arrangement and Achilles tendon moment arms (calculated by the gradient of tendon excursion versus ankle joint angle) were analyzed for each athlete using ultrasonography. Achilles tendon moment arm, foot and ankle skeletal geometry, fascicle arrangement as well as the ratio of fascicle length to Achilles tendon moment arm showed no significant (p > 0.05) correlation with sprint performance, nor were there any differences in the analyzed musculoskeletal parameters between the fast and slow sprinter group. Our findings provide evidence that differences in sprint ability in world-class athletes are not a result of differences in the geometrical design of the lower leg even when considering both skeletal and muscular components.},
  language  = {en}
}
@article{ArampatzisPeperBierbaumetal.2010,
  author    = {Arampatzis, Adamantios and Peper, Andreas and Bierbaum, Stefanie and Albracht, Kirsten},
  title     = {Plasticity of human Achilles tendon mechanical and morphological properties in response to cyclic strain},
  series = {Journal of Biomechanics},
  volume    = {43},
  journal   = {Journal of Biomechanics},
  number    = {16},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2010.08.014},
  pages     = {3073 -- 3079},
  year      = {2010},
  abstract  = {The purpose of the current study in combination with our previous published data (Arampatzis et al., 2007) was to examine the effects of a controlled modulation of strain magnitude and strain frequency applied to the Achilles tendon on the plasticity of tendon mechanical and morphological properties. Eleven male adults (23.9±2.2 yr) participated in the study. The participants exercised one leg at low magnitude tendon strain (2.97±0.47\%), and the other leg at high tendon strain magnitude (4.72±1.08\%) of similar frequency (0.5 Hz, 1 s loading, 1 s relaxation) and exercise volume (integral of the plantar flexion moment over time) for 14 weeks, 4 days per week, 5 sets per session. The exercise volume was similar to the intervention of our earlier study (0.17 Hz frequency; 3 s loading, 3 s relaxation) allowing a direct comparison of the results. Before and after the intervention ankle joint moment has been measured by a dynamometer, tendon-aponeurosis elongation by ultrasound and cross-sectional area of the Achilles tendon by magnet resonance images (MRI). We found a decrease in strain at a given tendon force, an increase in tendon-aponeurosis stiffness and tendon elastic modulus of the Achilles tendon only in the leg exercised at high strain magnitude. The cross-sectional area (CSA) of the Achilles tendon did not show any statistically significant (P>0.05) differences to the pre-exercise values in both legs. The results indicate a superior improvement in tendon properties (stiffness, elastic modulus and CSA) at the low frequency (0.17 Hz) compared to the high strain frequency (0.5 Hz) protocol. These findings provide evidence that the strain magnitude applied to the Achilles tendon should exceed the value, which occurs during habitual activities to trigger adaptational effects and that higher tendon strain duration per contraction leads to superior tendon adaptational responses.},
  language  = {en}
}
@article{AggeloussisGiannakouAlbrachtetal.2010,
  author    = {Aggeloussis, Nickos and Giannakou, Erasmia and Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Reproducibility of fascicle length and pennation angle of gastrocnemius medialis in human gait in vivo},
  series = {Gait and Posture},
  volume    = {31},
  journal   = {Gait and Posture},
  number    = {1},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0966-6362},
  doi       = {10.1016/j.gaitpost.2009.08.249},
  pages     = {73 -- 77},
  year      = {2010},
  abstract  = {The purpose of the current study was to examine the reproducibility of fascicle length and pennation angle of gastrocnemius medialis while human walking. To the best of our knowledge, this is the first study of the reproducibility of fascicle length and pennation angle of gastrocnemius medialis in vivo during human gait. Twelve males performed 10 gait trials on a treadmill, in 2 separate days. B-mode ultrasonography, with the ultrasound probe firmly adjusted in the transverse and frontal planes using a special cast, was used to measure the fascicle length and the pennation angle of the gastrocnemius medialis (GM). A Vicon 624 system with three cameras operating at 120 Hz was also used to record the ankle and knee joint angles. The results showed that measurements of fascicle length and pennation angle showed high reproducibility during the gait cycle, both within the same day and between different days. Moreover, the root mean square differences between the repeated waveforms of both variables were very small, compared with their ranges (fascicle length: RMS = ∼3 mm, range: 38-63 mm; pennation angle: RMS = ∼1.5°, range: 22-32°). However, their reproducibility was lower compared to the joint angles. It was found that representative data have to be derived by a wide number of gait trials (fascicle length ∼six trials, pennation angle more than 10 trials), to assure the reliability of the fascicle length and pennation angle in human gait.},
  language  = {en}
}
@article{ArampatzisKaramanidisMademlietal.2009,
  author    = {Arampatzis, Adamantios and Karamanidis, Kiros and Mademli, Lida and Albracht, Kirsten},
  title     = {Plasticity of the human tendon to short and long-term mechanical loading},
  series = {Exercise and Sport Sciences Reviews},
  volume    = {37},
  journal   = {Exercise and Sport Sciences Reviews},
  number    = {2},
  issn      = {1538-3008},
  doi       = {10.1097/JES.0b013e31819c2e1d},
  pages     = {66 -- 72},
  year      = {2009},
  language  = {en}
}
@article{AlbrachtArampatzisBaltzopoulos2008,
  author    = {Albracht, Kirsten and Arampatzis, A. and Baltzopoulos, V.},
  title     = {Assessment of muscle volume and physiological cross-sectional area of the human triceps surae muscle in vivo},
  series = {Journal of Biomechanics},
  volume    = {41},
  journal   = {Journal of Biomechanics},
  issn      = {0021-9290},
  doi       = {10.1016/j.jbiomech.2008.04.020},
  pages     = {2211 -- 2218},
  year      = {2008},
  language  = {en}
}
@article{AlbannaLuekeSchubertetal.2019,
  author    = {Albanna, Walid and L{\"u}ke, Jan Niklas and Schubert, Gerrit Alexander and Dibu{\´e}-Adjei, Maxine and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Steiger, Hans-Jakob and H{\"a}nggi, Daniel and Kamp, Marcel A. and Schneider, Toni and Neumaier, Felix},
  title     = {Modulation of Ca v 2.3 channels by unconjugated bilirubin (UCB) - Candidate mechanism for UCB-induced neuromodulation and neurotoxicity},
  series = {Molecular and Cellular Neuroscience},
  volume    = {96},
  journal   = {Molecular and Cellular Neuroscience},
  number    = {4},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1044-7431},
  doi       = {10.1016/j.mcn.2019.03.003},
  pages     = {35 -- 46},
  year      = {2019},
  language  = {en}
}
@article{QuittmannMeskemperAlbrachtetal.2020,
  author    = {Quittmann, Oliver J. and Meskemper, Joshua and Albracht, Kirsten and Abel, Thomas and Foitschik, Tina and Str{\"u}der, Heiko K.},
  title     = {Normalising surface EMG of ten upper-extremity muscles in handcycling: Manual resistance vs. sport-specific MVICs},
  series = {Journal of Electromyography and Kinesiology},
  volume    = {51},
  journal   = {Journal of Electromyography and Kinesiology},
  number    = {Article 102402},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1050-6411},
  doi       = {10.1016/j.jelekin.2020.102402},
  year      = {2020},
  abstract  = {Muscular activity in terms of surface electromyography (sEMG) is usually normalised to maximal voluntary isometric contractions (MVICs). This study aims to compare two different MVIC-modes in handcycling and examine the effect of moving average window-size. Twelve able-bodied male competitive triathletes performed ten MVICs against manual resistance and four sport-specific trials against fixed cranks. sEMG of ten muscles [M. trapezius (TD); M. pectoralis major (PM); M. deltoideus, Pars clavicularis (DA); M. deltoideus, Pars spinalis (DP); M. biceps brachii (BB); M. triceps brachii (TB); forearm flexors (FC); forearm extensors (EC); M. latissimus dorsi (LD) and M. rectus abdominis (RA)] was recorded and filtered using moving average window-sizes of 150, 200, 250 and 300 ms. Sport-specific MVICs were higher compared to manual resistance for TB, DA, DP and LD, whereas FC, TD, BB and RA demonstrated lower values. PM and EC demonstrated no significant difference between MVIC-modes. Moving average window-size had no effect on MVIC outcomes. MVIC-mode should be taken into account when normalised sEMG data are illustrated in handcycling. Sport-specific MVICs seem to be suitable for some muscles (TB, DA, DP and LD), but should be augmented by MVICs against manual/mechanical resistance for FC, TD, BB and RA.},
  language  = {en}
}
@article{KoppSchunckGosauetal.2020,
  author    = {Kopp, Alexander and Schunck, Laura and Gosau, Martin and Smeets, Ralf and Burg, Simon and Fuest, Sandra and Kr{\"o}ger, Nadja and Zinser, Max and Krohn, Sebastian and Behbahani, Mehdi and K{\"o}pf, Marius and Lauts, Lisa and Rutkowski, Rico},
  title     = {Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes},
  series = {International Journal of Molecular Sciences},
  volume    = {21},
  journal   = {International Journal of Molecular Sciences},
  number    = {18 art. no. 6704},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1422-0067},
  doi       = {10.3390/ijms21186704},
  year      = {2020},
  abstract  = {In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live-dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes.},
  language  = {en}
}
@article{QuittmannMeskemperAbeletal.2018,
  author    = {Quittmann, Oliver J. and Meskemper, Joshua and Abel, Thomas and Albracht, Kirsten and Foitschik, Tina and Rojas-Vega, Sandra and Str{\"u}der, Heiko K.},
  title     = {Kinematics and kinetics of handcycling propulsion at increasing workloads in able-bodied subjects},
  series = {Sports Engineereing},
  volume    = {21},
  journal   = {Sports Engineereing},
  number    = {21},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1460-2687},
  doi       = {10.1007/s12283-018-0269-y},
  pages     = {283 -- 294},
  year      = {2018},
  abstract  = {In Paralympic sports, biomechanical optimisation of movements and equipment seems to be promising for improving performance. In handcycling, information about the biomechanics of this sport is mainly provided by case studies. The aim of the current study was (1) to examine changes in handcycling propulsion kinematics and kinetics due to increasing workloads and (2) identify parameters that are associated with peak aerobic performance. Twelve non-disabled male competitive triathletes without handcycling experience voluntarily participated in the study. They performed an initial familiarisation protocol and incremental step test until exhaustion in a recumbent racing handcycle that was attached to an ergometer. During the incremental test, tangential crank kinetics, 3D joint kinematics, blood lactate and ratings of perceived exertion (local and global) were identified. As a performance criterion, the maximal power output during the step test (Pmax) was calculated and correlated with biomechanical parameters. For higher workloads, an increase in crank torque was observed that was even more pronounced in the pull phase than in the push phase. Furthermore, participants showed an increase in shoulder internal rotation and abduction and a decrease in elbow flexion and retroversion. These changes were negatively correlated with performance. At high workloads, it seems that power output is more limited by the transition from pull to push phase than at low workloads. It is suggested that successful athletes demonstrate small alterations of their kinematic profile due to increasing workloads. Future studies should replicate and expand the test spectrum (sprint and continuous loads) as well as use methods like surface electromyography (sEMG) with elite handcyclists.},
  language  = {de}
}
@article{ConzenAlbannaWeissetal.2018,
  author    = {Conzen, Catharina and Albanna, Walid and Weiss, Miriam and K{\"u}rten, David and Vilser, Walthard and Kotliar, Konstantin and Z{\"a}ske, Charlotte and Clusmann, Hans and Schubert, Gerrit Alexander},
  title     = {Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes},
  series = {Translational Stroke Research},
  journal   = {Translational Stroke Research},
  number    = {9},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {1868-601X},
  doi       = {10.1007/s12975-017-0585-8},
  pages     = {284 -- 293},
  year      = {2018},
  abstract  = {Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome.},
  language  = {en}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "F{\"o}rderung von innovativen Netzwerken" (InnoNet) des Bundesministerium f{\"u}r Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen [u.a.]},
  doi       = {10.2314/GBV:68757076X},
  year      = {2011},
  language  = {de}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten f{\"u}r die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:782964621},
  year      = {2011},
  language  = {de}
}
@article{BrockhausBehbahaniMurisetal.2021,
  author    = {Brockhaus, Moritz K. and Behbahani, Mehdi and Muris, Farina and Jansen, Sebastian V. and Schmitz- Rode, Thomas and Steinseifer, Ulrich and Clauser, Johanna C.},
  title     = {In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept},
  series = {Artificial Organs},
  volume    = {45},
  journal   = {Artificial Organs},
  number    = {12},
  publisher = {Wiley},
  address   = {Weinheim},
  issn      = {1525-1594},
  doi       = {10.1111/aor.14046},
  pages     = {1513 -- 1521},
  year      = {2021},
  abstract  = {Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6\% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential.},
  language  = {en}
}
@techreport{Artmann2004,
  author    = {Artmann, Gerhard},
  title     = {Escherichia Coli Infektion und Zellsch{\"a}digung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {J{\"u}lich},
  doi       = {10.2314/GBV:482527137},
  year      = {2004},
  language  = {de}
}
@techreport{Artmann2011,
  author    = {Artmann, Gerhard},
  title     = {Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten. Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:747569150},
  year      = {2011},
  language  = {de}
}
@techreport{ArtmannBaeumler2002,
  author    = {Artmann, Gerhard and B{\"a}umler, H.},
  title     = {Pharmamikrocontainer mit designgesteuerter Permeabilit{\"a}t als Transporter f{\"u}r ausgew{\"a}hlte Pharmaka. Ein Gemeinschaftsprojekt im Forschungsschwerpunkt "Celluar Engineering" [Laufzeit: 01.09.2000 - 28.02.2002]},
  publisher = {FH Aachen},
  address   = {J{\"u}lich},
  year      = {2002},
  language  = {de}
}
@techreport{TemizArtmann2010,
  author    = {Temiz Artmann, Ayseg{\"u}l},
  title     = {Fr{\"u}hgeburtenrate mindern durch ein Prognoseverfahren f{\"u}r den vorzeitigen Blasensprung - PROMPT (Premature rupture of membranes prediction test) : Abschlussbericht ; Laufzeit des Vorhabens: 01.03.2007 - 31.12.2009},
  publisher = {Technische Informationsbibliothek u. Universit{\"a}tsbibliothek},
  address   = {Aachen},
  doi       = {10.2314/GBV:644277858},
  year      = {2010},
  language  = {de}
}
@article{ArampatzisKaramanidisAlbracht2007,
  author    = {Arampatzis, Adamantios and Karamanidis, Kiros and Albracht, Kirsten},
  title     = {Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude},
  series = {Journal of Experimental Biology},
  volume    = {210},
  journal   = {Journal of Experimental Biology},
  number    = {15},
  issn      = {0022-0949},
  doi       = {10.1242/jeb.003814},
  pages     = {2743 -- 2753},
  year      = {2007},
  language  = {en}
}
@article{AlbrachtArampatzis2006,
  author    = {Albracht, Kirsten and Arampatzis, Adamantios},
  title     = {Influence of the mechanical properties of the muscle-tendon unit on force generation in runners with different running economy},
  series = {Biological Cybernetics},
  volume    = {95},
  journal   = {Biological Cybernetics},
  number    = {1},
  issn      = {1432-0770},
  doi       = {10.1007/s00422-006-0070-z},
  pages     = {87 -- 96},
  year      = {2006},
  language  = {en}
}
@incollection{AbelBoninAlbrachtetal.2015,
  author    = {Abel, Thomas and Bonin, Dominik and Albracht, Kirsten and Zeller, Sebastian and Burkett, Brendan},
  title     = {Kinematische Untersuchung der Kurbelbewegung im Handcycling: Entwicklung einer sportartspezifischen Methode},
  series = {Behindertensport 1951-2011 : Historische und aktuelle Aspekte im nationalen und internationalen Dialog},
  booktitle = {Behindertensport 1951-2011 : Historische und aktuelle Aspekte im nationalen und internationalen Dialog},
  publisher = {Meyer \& Meyer},
  address   = {Aachen},
  isbn      = {9783898997249},
  pages     = {82 -- 91},
  year      = {2015},
  language  = {de}
}
@inproceedings{KolditzAlbinAlbrachtetal.2016,
  author    = {Kolditz, Melanie and Albin, Thivaharan and Albracht, Kirsten and Br{\"u}ggemann, Gert-Peter and Abel, Dirk},
  title     = {Isokinematic leg extension training with an industrial robot},
  series = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore},
  booktitle = {6th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob) June 26-29, 2016. UTown, Singapore},
  doi       = {10.1109/BIOROB.2016.7523750},
  pages     = {950 -- 955},
  year      = {2016},
  language  = {de}
}
@article{HeinkeKnickerAlbracht2018,
  author    = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten},
  title     = {Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes},
  series = {Isokinetics and Exercise Science},
  volume    = {26},
  journal   = {Isokinetics and Exercise Science},
  number    = {4},
  publisher = {IOS Press},
  address   = {Amsterdam},
  issn      = {1878-5913},
  doi       = {10.3233/IES-184111},
  pages     = {265 -- 274},
  year      = {2018},
  abstract  = {BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.},
  language  = {en}
}
@article{KotliarLanzl2018,
  author    = {Kotliar, Konstantin and Lanzl, Ines},
  title     = {Vaskul{\"a}re Biomarker der retinalen Gef{\"a}βanalyse},
  series = {Klinische Monatsbl{\"a}tter fur Augenheilkunde},
  volume    = {235},
  journal   = {Klinische Monatsbl{\"a}tter fur Augenheilkunde},
  number    = {12},
  publisher = {Thieme},
  address   = {Stuttgart},
  issn      = {0023-2165},
  doi       = {10.1055/a-0774-7987},
  pages     = {1352 -- 1359},
  year      = {2018},
  abstract  = {Mit modernen nicht invasiven bildgebenden Verfahren lassen sich anhand der Fundusfotografie bzw. der optischen Verfilmung Aspekte der funktionellen und strukturellen retinalen Gef{\"a}ßver{\"a}nderungen objektiv untersuchen. Der Zustand und das Verhalten retinaler Gef{\"a}ße beeinflussen im pr{\"a}-, post- und kapillaren Bereich den Blutfluss und str{\"o}mungsbedingte Stoffwechselverh{\"a}ltnisse passiv und aktiv {\"u}ber den Gef{\"a}ßdurchmesser. Retinale Gef{\"a}ße gleichen von Aufbau und Funktion den zerebralen Gef{\"a}ßen und spiegeln den Zustand der Mikrozirkulation wider. Mithilfe von aus den Gef{\"a}ßweiten berechneten Biomarkern soll eine Aussage {\"u}ber die Prognose von systemischen vaskul{\"a}r bedingten Erkrankungen getroffen werden. Die statische retinale Gef{\"a}ßanalyse befasst sich mit der Untersuchung des Zustandes der pr{\"a}- und postkapillaren Gef{\"a}ßdurchmesser der retinalen Mikrozirkulation anhand einer optischen Fundusaufnahme. Bei der dynamischen retinalen Gef{\"a}ßanalyse wird der L{\"a}ngsschnitt eines retinalen Gef{\"a}ßes nicht invasiv funktionell und strukturell {\"u}ber einen Zeitraum vor, w{\"a}hrend und nach einer spezifischen vaskul{\"a}ren Stimulation untersucht. Die genaue Methodologie der Auswertung und die Bezeichnung der Parameter variieren bei unterschiedlichen Ans{\"a}tzen. Mittels retinaler Gef{\"a}ßanalyse wurden bislang mehrere klinische Querschnitts- und Interventionsstudien in der Augenheilkunde und anderen Fachgebieten, inkl. Kardiologie, Neurologie, Neurochirurgie, Nephrologie, Gyn{\"a}kologie, Sportmedizin, Diabetologie, Hypertensiologie usw. durchgef{\"u}hrt. Mit der statischen retinalen Gef{\"a}ßanalyse steht eine kosteng{\"u}nstige, reproduzierbare, nicht invasive Screeningtechnik zur Verf{\"u}gung, um eine prognostische Aussage {\"u}ber die Gef{\"a}ßgesundheit eines individuellen Patienten zu treffen. Die dynamische retinale Gef{\"a}ßanalyse besitzt ein weiteres diagnostisches Anwendungsspektrum als die statische, da sie das Verhalten retinaler Gef{\"a}ße zeitkontinuierlich untersucht. Die Evaluation vaskul{\"a}rer Erkrankungen sowie zerebro- bzw. kardiovaskul{\"a}rer Morbidit{\"a}t und Mortalit{\"a}t mittels mehrerer methodologischer Modalit{\"a}ten retinaler Gef{\"a}ßanalyse mit ihren jeweiligen quantitativen Biomarkern bietet eine zukunftstr{\"a}chtige diagnostische Perspektive. Die interdisziplin{\"a}re klinische Anwendung dieser vaskul{\"a}ren Biomarker gewinnt zunehmend an Bedeutung, sowohl in der Augenheilkunde als auch in anderen Fachgebieten.},
  language  = {de}
}
@incollection{MuellerJungSchmoelzer2015,
  author    = {Mueller, Wolfram and Jung, Alexander and Schm{\"o}lzer, Bernhard},
  title     = {Der Einfluss der H{\"o}he {\"u}ber dem Meeresspiegel auf die Flugbahnen im Schispringen},
  series = {Jahrbuch 2015 - {\"O}sterreichische Gesellschaft f{\"u}r Alpin- und H{\"o}henmedizin},
  booktitle = {Jahrbuch 2015 - {\"O}sterreichische Gesellschaft f{\"u}r Alpin- und H{\"o}henmedizin},
  editor    = {Faulhaber, Martin and Schobersberger, Wolfgang and Schobersberger, Beatrix and Sumann, G{\"u}nther and Domej, Wolfgang},
  publisher = {{\"O}sterreichische Gesellschaft f{\"u}r Alpin- und H{\"o}henmedizin},
  address   = {Innsbruck},
  isbn      = {978-3-9501312-5-3},
  pages     = {173 -- 190},
  year      = {2015},
  language  = {de}
}
@phdthesis{Gossmann2015,
  author    = {Goßmann, Matthias},
  title     = {Entwicklung eines autokontraktilen Herzmuskelmodells zur funktionalen Medikamenten- und Toxinforschung},
  publisher = {Universit{\"a}tsbibliothek Duisburg-Essen},
  address   = {Duisburg ; Essen},
  year      = {2015},
  language  = {de}
}
@phdthesis{Seifarth2015,
  author    = {Seifarth, Volker},
  title     = {Ureteral tissue engineering : development of a bioreactor system and subsequent characterization of the generated biohybrids},
  publisher = {Universit{\"a}tsbibliothek Duisburg-Essen},
  address   = {Duisburg ; Essen},
  year      = {2015},
  language  = {en}
}
@phdthesis{Oflaz2012,
  author    = {Oflaz, Hakan},
  title     = {Entwicklung eines Prototypen zur Prognose von Fr{\"u}hgeburten : ein biomedizintechnischer Ansatz},
  publisher = {Deutsche Zentralbibliothek f{\"u}r Medizin},
  address   = {K{\"o}ln},
  doi       = {10.4126/38m-004639208},
  year      = {2012},
  language  = {en}
}
@phdthesis{Behbahani2011,
  author    = {Behbahani, Mehdi},
  title     = {Modeling and Simulation of Shear-Dependent Platelet Reactions in Blood Vessels and Blood-Contacting Medical Devices},
  publisher = {Verlag Dr. Hut},
  address   = {M{\"u}nchen},
  isbn      = {978-3-8439-0134-5},
  year      = {2011},
  language  = {en}
}
@phdthesis{KurulganDemirci2012,
  author    = {Kurulgan Demirci, Eylem},
  title     = {The effect of rhAPC on contractile tension : an in-vitro sepsis model of cardiomyocytes and endothelial cells},
  year      = {2012},
  language  = {en}
}
@phdthesis{Trzewik2007,
  author    = {Trzewik, J{\"u}rgen},
  title     = {Experimental analysis of biaxial mechanical tension in cell monolayers and cultured three-dimensional tissues: the celldrum technology},
  publisher = {Univerist{\"a}tsverlg Ilmenau},
  address   = {Ilmenau},
  year      = {2007},
  language  = {en}
}
@phdthesis{Foeckler2016,
  author    = {F{\"o}ckler, Nicole},
  title     = {Biomarker zur Prognose von Fr{\"u}hgeburten : ein biomedizintechnischer Ansatz},
  publisher = {Deutsche Zentralbibliothek f{\"u}r Medizin},
  address   = {K{\"o}ln},
  doi       = {10.4126/FRL01-006401575},
  pages     = {VII, 117 S.},
  year      = {2016},
  language  = {de}
}
@phdthesis{BassamAbduljabbar2015,
  author    = {Bassam Abduljabbar, Rasha},
  title     = {Physikalisch-chemische Steuerung der Proteinstabilit{\"a}t in biologischen Systemen},
  year      = {2015},
  language  = {de}
}
@phdthesis{Duong2015,
  author    = {Duong, Minh Tuan},
  title     = {Hyperelastic modeling and soft-tissue growth integrated with the smoothed finite element method - SFEM},
  publisher = {RWTH Aachen University},
  pages     = {174 S.},
  year      = {2015},
  language  = {en}
}
@phdthesis{Pham2011,
  author    = {Pham, Phu Tinh},
  title     = {Upper bound limit and shakedown analysis of elastic-plastic bounded linearly kinematic hardening structures},
  publisher = {RWTH Aachen University},
  address   = {Aachen},
  pages     = {140 S.},
  year      = {2011},
  language  = {en}
}
@article{QuittmannAbelAlbrachtetal.2020,
  author    = {Quittmann, Oliver J. and Abel, Thomas and Albracht, Kirsten and Meskemper, Joshua and Foitschik, Tina and Str{\"u}der, Heiko K.},
  title     = {Biomechanics of handcycling propulsion in a 30-min continuous load test at lactate threshold: Kinetics, kinematics, and muscular activity in able-bodied participants},
  series = {European Journal of Applied Physiology},
  journal   = {European Journal of Applied Physiology},
  number    = {120},
  publisher = {Springer},
  address   = {Heidelberg},
  issn      = {1439-6327},
  doi       = {10.1007/s00421-020-04373-x},
  pages     = {1403 -- 1415},
  year      = {2020},
  abstract  = {Purpose This study aims to investigate the biomechanics of handcycling during a continuous load trial (CLT) to assess the mechanisms underlying fatigue in upper body exercise. Methods Twelve able-bodied triathletes performed a 30-min CLT at a power output corresponding to lactate threshold in a racing recumbent handcycle mounted on a stationary ergometer. During the CLT, ratings of perceived exertion (RPE), tangential crank kinetics, 3D joint kinematics, and muscular activity of ten muscles of the upper extremity and trunk were examined using motion capturing and surface electromyography. Results During the CLT, spontaneously chosen cadence and RPE increased, whereas crank torque decreased. Rotational work was higher during the pull phase. Peripheral RPE was higher compared to central RPE. Joint range of motion decreased for elbow-flexion and radial-duction. Integrated EMG (iEMG) increased in the forearm flexors, forearm extensors, and M. deltoideus (Pars spinalis). An earlier onset of activation was found for M. deltoideus (Pars clavicularis), M. pectoralis major, M. rectus abdominis, M. biceps brachii, and the forearm flexors. Conclusion Fatigue-related alterations seem to apply analogously in handcycling and cycling. The most distal muscles are responsible for force transmission on the cranks and might thus suffer most from neuromuscular fatigue. The findings indicate that peripheral fatigue (at similar lactate values) is higher in handcycling compared to leg cycling, at least for inexperienced participants. An increase in cadence might delay peripheral fatigue by a reduced vascular occlusion. We assume that the gap between peripheral and central fatigue can be reduced by sport-specific endurance training.},
  language  = {en}
}
@inproceedings{PohleFroehlichDalitzRichteretal.2020,
  author    = {Pohle-Fr{\"o}hlich, Regina and Dalitz, Christoph and Richter, Charlotte and Hahnen, Tobias and St{\"a}udle, Benjamin and Albracht, Kirsten},
  title     = {Estimation of muscle fascicle orientation in ultrasonic images},
  series = {Proceedings of the 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications - Volume 5},
  booktitle = {Proceedings of the 15th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications - Volume 5},
  publisher = {SciTePress},
  address   = {Set{\´u}bal, Portugal},
  isbn      = {978-989-758-402-2},
  doi       = {10.5220/0008933900790086},
  pages     = {79 -- 86},
  year      = {2020},
  abstract  = {We compare four different algorithms for automatically estimating the muscle fascicle angle from ultrasonic images: the vesselness filter, the Radon transform, the projection profile method and the gray level cooccurence matrix (GLCM). The algorithm results are compared to ground truth data generated by three different experts on 425 image frames from two videos recorded during different types of motion. The best agreement with the ground truth data was achieved by a combination of pre-processing with a vesselness filter and measuring the angle with the projection profile method. The robustness of the estimation is increased by applying the algorithms to subregions with high gradients and performing a LOESS fit through these estimates.},
  language  = {en}
}
@article{MalikAbdievaUalievaetal.2019,
  author    = {Malik, A. M. and Abdieva, G. Zh. and Ualieva, P. S. and Zhubanova, A. A. and Temiz Artmann, Ayseg{\"u}l},
  title     = {CКPИНИНГ МИКPOOPГAНИЗМOВ-ДECТPУКТOPOВ XЛOРOPГAНИЧECКИX ЗAГPЯЗНИТEЛEЙ},
  series = {Eurasian Journal of Ecology},
  volume    = {61},
  journal   = {Eurasian Journal of Ecology},
  number    = {4},
  issn      = {2617-7358},
  pages     = {61 -- 71},
  year      = {2019},
  language  = {ru}
}
@article{AttarMerkKotliaretal.2019,
  author    = {Attar, Mandana Hossein Zadeh and Merk, Hans F. and Kotliar, Konstantin and Wurpts, Gerda and R{\"o}seler, Stefani and Moll-Slodowy, Silke and Plange, Johann and Baron, Jens Malte and Balakirski, Galina},
  title     = {The CD63 basophil activation test as a diagnostic tool for assessing autoimmunity in patients with chronic spontaneous urticaria},
  series = {European Journal of Dermatology},
  volume    = {29},
  journal   = {European Journal of Dermatology},
  number    = {6},
  doi       = {10.1684/ejd.2019.3680},
  pages     = {614 -- 618},
  year      = {2019},
  language  = {en}
}
@incollection{AzatKerimkulovaMansurovetal.2020,
  author    = {Azat, Seitkhan and Kerimkulova, Almagul R. and Mansurov, Zulkhair A. and Adekenov, Sergazy and Artmann, Gerhard},
  title     = {The Use of Fusicoccin as Anticancer Compound},
  series = {Carbon Nanomaterials in Biomedicine and the Environment},
  booktitle = {Carbon Nanomaterials in Biomedicine and the Environment},
  publisher = {Jenny Stanford Publishing},
  address   = {New York},
  isbn      = {978-0-429-42864-7},
  doi       = {10.1201/9780429428647-8},
  pages     = {149 -- 172},
  year      = {2020},
  abstract  = {The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation.},
  language  = {en}
}
@article{MandekarHollandThielenetal.2022,
  author    = {Mandekar, Swati and Holland, Abigail and Thielen, Moritz and Behbahani, Mehdi and Melnykowycz, Mark},
  title     = {Advancing towards Ubiquitous EEG, Correlation of In-Ear EEG with Forehead EEG},
  series = {Sensors},
  volume    = {22},
  journal   = {Sensors},
  number    = {4},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {1424-8220},
  doi       = {10.3390/s22041568},
  pages     = {1 -- 19},
  year      = {2022},
  abstract  = {Wearable EEG has gained popularity in recent years driven by promising uses outside of clinics and research. The ubiquitous application of continuous EEG requires unobtrusive form-factors that are easily acceptable by the end-users. In this progression, wearable EEG systems have been moving from full scalp to forehead and recently to the ear. The aim of this study is to demonstrate that emerging ear-EEG provides similar impedance and signal properties as established forehead EEG. EEG data using eyes-open and closed alpha paradigm were acquired from ten healthy subjects using generic earpieces fitted with three custom-made electrodes and a forehead electrode (at Fpx) after impedance analysis. Inter-subject variability in in-ear electrode impedance ranged from 20 kΩ to 25 kΩ at 10 Hz. Signal quality was comparable with an SNR of 6 for in-ear and 8 for forehead electrodes. Alpha attenuation was significant during the eyes-open condition in all in-ear electrodes, and it followed the structure of power spectral density plots of forehead electrodes, with the Pearson correlation coefficient of 0.92 between in-ear locations ELE (Left Ear Superior) and ERE (Right Ear Superior) and forehead locations, Fp1 and Fp2, respectively. The results indicate that in-ear EEG is an unobtrusive alternative in terms of impedance, signal properties and information content to established forehead EEG.},
  language  = {en}
}
@article{NiedermeyerZhouDursunetal.2016,
  author    = {Niedermeyer, Angela and Zhou, Bei and Dursun, G{\"o}zde and Temiz Artmann, Ayseg{\"u}l and Markert, Bernd},
  title     = {An examination of tissue engineered scaffolds in a bioreactor},
  series = {Proceedings in Applied Mathematics and Mechanics PAMM},
  volume    = {16},
  journal   = {Proceedings in Applied Mathematics and Mechanics PAMM},
  number    = {1},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1617-7061},
  doi       = {10.1002/pamm.201610038},
  pages     = {99 -- 100},
  year      = {2016},
  abstract  = {Replacement tissues, designed to fill in articular cartilage defects, should exhibit the same properties as the native material. The aim of this study is to foster the understanding of, firstly, the mechanical behavior of the material itself and, secondly, the influence of cultivation parameters on cell seeded implants as well as on cell migration into acellular implants. In this study, acellular cartilage replacement material is theoretically, numerically and experimentally investigated regarding its viscoelastic properties, where a phenomenological model for practical applications is developed. Furthermore, remodeling and cell migration are investigated.},
  language  = {en}
}
@article{TranMottaghyArltKoerferetal.2017,
  author    = {Tran, Linda and Mottaghy, K. and Arlt-K{\"o}rfer, Sabine and Waluga, Christian and Behbahani, Mehdi},
  title     = {An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system},
  series = {Biomedizinische Technik},
  volume    = {62},
  journal   = {Biomedizinische Technik},
  number    = {4},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {0013-5585},
  doi       = {10.1515/bmt-2015-0034},
  pages     = {383 -- 392},
  year      = {2017},
  language  = {en}
}
@article{AlbannaLuekeSjapicetal.2017,
  author    = {Albanna, Walid and Lueke, Jan Niklas and Sjapic, Volha and Kotliar, Konstantin and Hescheler, J{\"u}rgen and Clusmann, Hans and Sjapic, Sergej and Alpdogan, Serdan and Schneider, Toni and Schubert, Gerrit Alexander and Neumaier, Felix},
  title     = {Electroretinographic Assessment of Inner Retinal Signaling in the Isolated and Superfused Murine Retina},
  series = {Current Eye Research},
  journal   = {Current Eye Research},
  number    = {Article in press},
  publisher = {Taylor \& Francis},
  address   = {London},
  issn      = {1460-2202},
  doi       = {10.1080/02713683.2017.1339807},
  pages     = {1 -- 9},
  year      = {2017},
  language  = {en}
}
@article{KotliarHauserOrtneretal.2017,
  author    = {Kotliar, Konstantin and Hauser, Christine and Ortner, Marion and Muggenthaler, Claudia and Diehl-Schmid, Janine and Angermann, Susanne and Hapfelmeier, Alexander and Schmaderer, Christoph and Grimmer, Timo},
  title     = {Altered neurovascular coupling as measured by optical imaging: a biomarker for Alzheimer's disease},
  series = {Scientific Reports},
  volume    = {7},
  journal   = {Scientific Reports},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-017-13349-5},
  pages     = {1 -- 11},
  year      = {2017},
  language  = {en}
}
@article{WerkhausenAlbrachtCroninetal.2017,
  author    = {Werkhausen, Amelie and Albracht, Kirsten and Cronin, Neil J. and Meier, Rahel and Mojsen-Moeller, Jens and Seynnes, Olivier R.},
  title     = {Modulation of muscle-tendon interaction in the human triceps surae during an energy dissipation task},
  series = {Journal of Experimental Biology},
  volume    = {220},
  journal   = {Journal of Experimental Biology},
  number    = {22},
  issn      = {0022-0949},
  doi       = {10.1242/jeb.164111},
  pages     = {4141 -- 4149},
  year      = {2017},
  language  = {en}
}
@article{LapitanRogatkinPersheyevetal.2018,
  author    = {Lapitan, Denis G. and Rogatkin, Dmitrii A. and Persheyev, Sydulla K. and Kotliar, Konstantin},
  title     = {False spectra formation in the differential two-channel scheme of the laser Doppler flowmeter},
  series = {Biomedizinische Technik},
  volume    = {63},
  journal   = {Biomedizinische Technik},
  number    = {4},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {0013-5585},
  doi       = {10.1515/bmt-2017-0060},
  pages     = {439 -- 444},
  year      = {2018},
  abstract  = {Noise in the differential two-channel scheme of a classic laser Doppler flowmetry (LDF) instrument was studied. Formation of false spectral components in the output signal due to beating of electrical signals in the differential amplifier was found out. The improved block-diagram of the flowmeter was developed allowing to reduce the noise.},
  language  = {en}
}
@article{AlbannaKotliarLuekeetal.2018,
  author    = {Albanna, Walid and Kotliar, Konstantin and L{\"u}ke, Jan Niklas and Alpdogan, Serdar and Conzen, Catharina and Lindauer, Ute and Clusmann, Hans and Hescheler, J{\"u}rgen and Vilser, Walthard and Schneider, Toni and Schubert, Gerrit Alexander},
  title     = {Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis},
  series = {Plos one},
  volume    = {13},
  journal   = {Plos one},
  number    = {10},
  publisher = {PLOS},
  address   = {San Francisco},
  doi       = {10.1371/journal.pone.0204689},
  pages     = {e0204689},
  year      = {2018},
  abstract  = {Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals.},
  language  = {en}
}
@article{BalakirskiKotliarPaulyetal.2018,
  author    = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz},
  title     = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience},
  series = {Dermatologic Surgery},
  journal   = {Dermatologic Surgery},
  number    = {44 (12)},
  publisher = {Wolters Kluwer},
  doi       = {10.1097/DSS.0000000000001615},
  pages     = {1525 -- 1536},
  year      = {2018},
  abstract  = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.},
  language  = {en}
}
@article{RittwegerAlbrachtFluecketal.2018,
  author    = {Rittweger, J{\"o}rn and Albracht, Kirsten and Fl{\"u}ck, Martin and Ruoss, Severin and Brocca, Lorenza and Longa, Emanuela and Moriggi, Manuela and Seynnes, Olivier and Di Giulio, Irene and Tenori, Leonardo and Vignoli, Alessia and Capri, Miriam and Gelfi, Cecilia and Luchinat, Claudio and Franceschi, Claudio and Bottinelli, Roberto and Cerretelli, Paolo and Narici, Marco},
  title     = {Sarcolab pilot study into skeletal muscle's adaptation to longterm spaceflight},
  series = {npj Microgravity},
  volume    = {4},
  journal   = {npj Microgravity},
  number    = {1},
  publisher = {Nature Portfolio},
  issn      = {2373-8065},
  doi       = {10.1038/s41526-018-0052-1},
  pages     = {1 -- 9},
  year      = {2018},
  language  = {en}
}