@article{RoehlenPilasDahmenetal.2018,
  author    = {R{\"o}hlen, Desiree and Pilas, Johanna and Dahmen, Markus and Keusgen, Michael and Selmer, Thorsten and Sch{\"o}ning, Michael Josef},
  title     = {Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes},
  series = {Frontiers in Chemistry},
  journal   = {Frontiers in Chemistry},
  number    = {6},
  publisher = {Frontiers},
  address   = {Lausanne},
  doi       = {10.3389/fchem.2018.00284},
  pages     = {Artikel 284},
  year      = {2018},
  abstract  = {Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.},
  language  = {en}
}
@article{RodriguesMoraisNordietal.2018,
  author    = {Rodrigues, Raul T. and Morais, Paulo V. and Nordi, Cristina S. F. and Sch{\"o}ning, Michael Josef and Siqueira Jr., Jos{\´e} R. and Caseli, Luciano},
  title     = {Carbon Nanotubes and Algal Polysaccharides To Enhance the Enzymatic Properties of Urease in Lipid Langmuir-Blodgett Films},
  series = {Langmuir},
  volume    = {34},
  journal   = {Langmuir},
  number    = {9},
  publisher = {ACS Publications},
  address   = {Washington, DC},
  issn      = {1520-5827},
  doi       = {10.1021/acs.langmuir.7b04317},
  pages     = {3082 -- 3093},
  year      = {2018},
  abstract  = {Algal polysaccharides (extracellular polysaccharides) and carbon nanotubes (CNTs) were adsorbed on dioctadecyldimethylammonium bromide Langmuir monolayers to serve as a matrix for the incorporation of urease. The physicochemical properties of the supramolecular system as a monolayer at the air-water interface were investigated by surface pressure-area isotherms, surface potential-area isotherms, interfacial shear rheology, vibrational spectroscopy, and Brewster angle microscopy. The floating monolayers were transferred to hydrophilic solid supports, quartz, mica, or capacitive electrolyte-insulator-semiconductor (EIS) devices, through the Langmuir-Blodgett (LB) technique, forming mixed films, which were investigated by quartz crystal microbalance, fluorescence spectroscopy, and field emission gun scanning electron microscopy. The enzyme activity was studied with UV-vis spectroscopy, and the feasibility of the thin film as a urea sensor was essayed in an EIS sensor device. The presence of CNT in the enzyme-lipid LB film not only tuned the catalytic activity of urease but also helped to conserve its enzyme activity. Viability as a urease sensor was demonstrated with capacitance-voltage and constant capacitance measurements, exhibiting regular and distinctive output signals over all concentrations used in this work. These results are related to the synergism between the compounds on the active layer, leading to a surface morphology that allowed fast analyte diffusion owing to an adequate molecular accommodation, which also preserved the urease activity. This work demonstrates the feasibility of employing LB films composed of lipids, CNT, algal polysaccharides, and enzymes as EIS devices for biosensing applications.},
  language  = {en}
}
@book{SchoeningPoghossian2018,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak},
  title     = {Label-free biosensing: advanced materials, devices and applications},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-75219-8},
  pages     = {xii, 480 Seiten ; Illustrationen, Diagramme},
  year      = {2018},
  language  = {en}
}
@incollection{YoshinobuKrauseMiyamotoetal.2018,
  author    = {Yoshinobu, Tatsuo and Krause, Steffi and Miyamoto, Ko-ichiro and Werner, Frederik and Poghossian, Arshak and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {(Bio-)chemical Sensing and Imaging by LAPS and SPIM},
  series = {Label-free biosensing: advanced materials, devices and applications},
  booktitle = {Label-free biosensing: advanced materials, devices and applications},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-75219-8},
  pages     = {103 -- 132},
  year      = {2018},
  abstract  = {The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications.},
  language  = {en}
}
@inproceedings{BungTullis2018,
  author    = {Bung, Daniel B. and Tullis, Blake},
  title     = {Hydraulic Structures - ISHS2018 in Perspective},
  series = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  booktitle = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  isbn      = {978-0-692-13277-7},
  doi       = {10.15142/T3WH2B},
  pages     = {9 seiten},
  year      = {2018},
  language  = {en}
}
@inproceedings{ValeroVogelSchmidtetal.2018,
  author    = {Valero, Daniel and Vogel, Jochen and Schmidt, Daniel and Bung, Daniel B.},
  title     = {Three-dimensional flow structure inside the cavity of a non-aerated stepped chute},
  series = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  booktitle = {7th IAHR International Symposium on Hydraulic Structures, Aachen, Germany, 15-18 May},
  isbn      = {978-0-692-13277-7},
  doi       = {10.15142/T3GH17},
  pages     = {12 Seiten},
  year      = {2018},
  language  = {en}
}
@inproceedings{LudowicyRingsFingeretal.2018,
  author    = {Ludowicy, Jonas and Rings, Ren{\´e} and Finger, Felix and Braun, Carsten},
  title     = {Sizing Studies of Light Aircraft with Serial Hybrid Propulsion Systems},
  series = {Luft- und Raumfahrt - Digitalisierung und Vernetzung : Deutscher Luft- und Raumfahrtkongress 2018. 4. - 6. September 2018 - Friedrichshafen},
  booktitle = {Luft- und Raumfahrt - Digitalisierung und Vernetzung : Deutscher Luft- und Raumfahrtkongress 2018. 4. - 6. September 2018 - Friedrichshafen},
  pages     = {11 S.},
  year      = {2018},
  language  = {en}
}
@inproceedings{FingerGoettenBraun2018,
  author    = {Finger, Felix and G{\"o}tten, Falk and Braun, Carsten},
  title     = {Initial Sizing for a Family of Hybrid-Electric VTOL General Aviation Aircraft},
  series = {67. Deutscher Luft- und Raumfahrtkongress 2018},
  booktitle = {67. Deutscher Luft- und Raumfahrtkongress 2018},
  pages     = {14 S.},
  year      = {2018},
  language  = {en}
}
@inproceedings{LudowicyRingsFingeretal.2018,
  author    = {Ludowicy, Jonas and Rings, Ren{\´e} and Finger, Felix and Braun, Carsten},
  title     = {Sizing Studies of Light Aircraft with Parallel Hybrid Propulsion Systems},
  series = {Deutscher Luft- und Raumfahrtkongress 2018},
  booktitle = {Deutscher Luft- und Raumfahrtkongress 2018},
  doi       = {10.25967/480227},
  pages     = {15 S.},
  year      = {2018},
  language  = {en}
}
@article{GoettenFingerHavermannetal.2018,
  author    = {G{\"o}tten, Falk and Finger, Felix and Havermann, Marc and Braun, Carsten and Gomez, Francisco and Bill, C.},
  title     = {On the flight performance impact of landing gear drag reduction methods for unmanned air vehicles},
  series = {Deutscher Luft- und Raumfahrtkongress 2018},
  journal   = {Deutscher Luft- und Raumfahrtkongress 2018},
  publisher = {DGLR},
  address   = {Bonn},
  doi       = {10.25967/480058},
  pages     = {11 S.},
  year      = {2018},
  abstract  = {The flight performance impact of three different landing gear configurations on a small, fixed-wing UAV is analyzed with a combination of RANS CFD calculations and an incremental flight performance algorithm. A standard fixed landing gear configuration is taken as a baseline, while the influence of retracting the landing gear or applying streamlined fairings is investigated. A retraction leads to a significant parasite drag reduction, while also fairings promise large savings. The increase in lift-to-drag ratio is reduced at high lift coefficients due to the influence of induced drag. All configurations are tested on three different design missions with an incremental flight performance algorithm. A trade-off study is performed using the retracted or faired landing gear's weight increase as a variable. The analysis reveals only small mission performance gains as the aerodynamic improvements are negated by weight penalties. A new workflow for decision-making is presented that allows to estimate if a change in landing gear configuration is beneficial for a small UAV.},
  language  = {en}
}
@phdthesis{Keinz2018,
  author    = {Keinz, Jan},
  title     = {Optimization of a Dry Low NOx Micromix Combustor for an Industrial Gas Turbine Using Hydrogen-Rich Syngas Fuel},
  publisher = {Universit{\´e} Libre de Bruxelles - Brussels School of Engineering Aero-Thermo-Mechanics},
  address   = {Br{\"u}ssel},
  year      = {2018},
  language  = {en}
}
@inproceedings{RichterBraunsteinStaeudleetal.2018,
  author    = {Richter, Charlotte and Braunstein, Bjoern and St{\"a}udle, Benjamin and Attias, Julia and Suess, Alexander and Weber, T. and Rittweger, Joern and Green, David A. and Albracht, Kirsten},
  title     = {In vivo fascicle length of the gastrocnemius muscle during walking in simulated martian gravity using two different body weight support devices},
  series = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland},
  booktitle = {23rd Annual Congress of the European College of Sport Science, Dublin, Irland},
  year      = {2018},
  language  = {en}
}
@article{BerneckerKlierSternetal.2018,
  author    = {Bernecker, Andreas and Klier, Julia and Stern, Sebastian and Thiel, Lea},
  title     = {Sustaining high performance beyond public-sector pilot projects.},
  number    = {September 2018},
  organization    = {McKinsey\&Company},
  year      = {2018},
  language  = {en}
}
@techreport{BerneckerBoyerGathmann2018,
  type      = {Working Paper},
  author    = {Bernecker, Andreas and Boyer, Pierre and Gathmann, Christina},
  title     = {The Role of Electoral Incentives for Policy Innovation: Evidence from the US Welfare Reform},
  series = {CESifo Working Paper},
  journal   = {CESifo Working Paper},
  number    = {No. 6964},
  organization    = {CESifo Group Munich},
  issn      = {ISSN 2364-1428 (electronic version)},
  pages     = {60},
  year      = {2018},
  language  = {en}
}
@article{TekinAshikagaHorikawaetal.2018,
  author    = {Tekin, Nurettin and Ashikaga, Mitsugu and Horikawa, Atsushi and Funke, Harald},
  title     = {Enhancement of fuel flexibility of industrial gas turbines by development of innovative hydrogen combustion systems},
  series = {Gas for energy},
  journal   = {Gas for energy},
  number    = {2},
  publisher = {Vulkan-Verlag},
  address   = {Essen},
  pages     = {4},
  year      = {2018},
  abstract  = {For fuel flexibility enhancement hydrogen represents a possible alternative gas turbine fuel within future low emission power generation, in case of hydrogen production by the use of renewable energy sources such as wind energy or biomass. Kawasaki Heavy Industries, Ltd. (KHI) has research and development projects for future hydrogen society; production of hydrogen gas, refinement and liquefaction for transportation and storage, and utilization with gas turbine / gas engine for the generation of electricity. In the development of hydrogen gas turbines, a key technology is the stable and low NOx hydrogen combustion, especially Dry Low Emission (DLE) or Dry Low NOx (DLN) hydrogen combustion. Due to the large difference in the physical properties of hydrogen compared to other fuels such as natural gas, well established gas turbine combustion systems cannot be directly applied for DLE hydrogen combustion. Thus, the development of DLE hydrogen combustion technologies is an essential and challenging task for the future of hydrogen fueled gas turbines. The DLE Micro-Mix combustion principle for hydrogen fuel has been in development for many years to significantly reduce NOx emissions. This combustion principle is based on cross-flow mixing of air and gaseous hydrogen which reacts in multiple miniaturized "diffusion-type" flames. The major advantages of this combustion principle are the inherent safety against flashback and the low NOx-emissions due to a very short residence time of the reactants in the flame region of the micro-flames.},
  language  = {en}
}
@article{BalakirskiKotliarPaulyetal.2018,
  author    = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz},
  title     = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience},
  series = {Dermatologic Surgery},
  journal   = {Dermatologic Surgery},
  number    = {44 (12)},
  publisher = {Wolters Kluwer},
  doi       = {10.1097/DSS.0000000000001615},
  pages     = {1525 -- 1536},
  year      = {2018},
  abstract  = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.},
  language  = {en}
}
@inproceedings{FingerBraunBil2018,
  author    = {Finger, Felix and Braun, Carsten and Bil, Cees},
  title     = {Case studies in initial sizing for hybrid-electric general aviation aircraft},
  series = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio},
  booktitle = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio},
  doi       = {10.2514/6.2018-5005},
  year      = {2018},
  language  = {en}
}
@inproceedings{RendonDieckmannWeidleetal.2018,
  author    = {Rendon, Carlos and Dieckmann, Simon and Weidle, Mathias and Dersch, J{\"u}rgen and Teixeira Boura, Cristiano Jos{\´e} and Polklas, Thomas and Kuschel, Marcus and Herrmann, Ulf},
  title     = {Retrofitting of existing parabolic trough collector power plants with molten salt tower systems},
  series = {AIP Conference Proceedings},
  volume    = {2033},
  booktitle = {AIP Conference Proceedings},
  number    = {1},
  doi       = {10.1063/1.5067030},
  pages     = {030014-1 -- 030014-8},
  year      = {2018},
  language  = {en}
}
@article{FingerBraunBil2018,
  author    = {Finger, Felix and Braun, Carsten and Bil, Cees},
  title     = {Impact of electric propulsion technology and mission requirements on the performance of VTOL UAVs},
  series = {CEAS Aeronautical Journal},
  volume    = {10},
  journal   = {CEAS Aeronautical Journal},
  number    = {3},
  publisher = {Springer},
  issn      = {1869-5582 print},
  doi       = {10.1007/s13272-018-0352-x},
  pages     = {843},
  year      = {2018},
  abstract  = {One of the engineering challenges in aviation is the design of transitioning vertical take-off and landing (VTOL) aircraft. Thrust-borne flight implies a higher mass fraction of the propulsion system, as well as much increased energy consumption in the take-off and landing phases. This mass increase is typically higher for aircraft with a separate lift propulsion system than for aircraft that use the cruise propulsion system to support a dedicated lift system. However, for a cost-benefit trade study, it is necessary to quantify the impact the VTOL requirement and propulsion configuration has on aircraft mass and size. For this reason, sizing studies are conducted. This paper explores the impact of considering a supplemental electric propulsion system for achieving hovering flight. Key variables in this study, apart from the lift system configuration, are the rotor disk loading and hover flight time, as well as the electrical systems technology level for both batteries and motors. Payload and endurance are typically used as the measures of merit for unmanned aircraft that carry electro-optical sensors, and therefore the analysis focuses on these particular parameters.},
  language  = {en}
}
@inproceedings{EssingholtMeyerKuhnetal.2018,
  author    = {Essingholt, Felix and Meyer, Frederic and Kuhn, Peter and Schmidt, Philip and Benkner, Thorsten and Grabmaier, Anton},
  title     = {Non-invasive heart beat measurement using microwave resonators},
  series = {Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9-12 September 2018},
  booktitle = {Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9-12 September 2018},
  publisher = {MDPI},
  address   = {Basel},
  issn      = {2504-3900},
  doi       = {10.3390/proceedings2131002},
  pages     = {1002},
  year      = {2018},
  language  = {en}
}
@article{EngelHoltmannUlberetal.2018,
  author    = {Engel, Mareike and Holtmann, Dirk and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Increased Biobutanol Production by Mediator-Less Electro-Fermentation},
  series = {Biotechnology Journal},
  journal   = {Biotechnology Journal},
  number    = {Volume 14, Issue 4},
  publisher = {Wiley-VCH},
  issn      = {1860-7314},
  doi       = {10.1002/biot.201800514},
  pages     = {Artikel 1800514},
  year      = {2018},
  abstract  = {A future bio-economy should not only be based on renewable raw materials but also in the raise of carbon yields of existing production routes. Microbial electrochemical technologies are gaining increased attention for this purpose. In this study, the electro-fermentative production of biobutanol with C. acetobutylicum without the use of exogenous mediators is investigated regarding the medium composition and the reactor design. It is shown that the use of an optimized synthetic culture medium allows higher product concentrations, increased biofilm formation, and higher conductivities compared to a synthetic medium supplemented with yeast extract. Moreover, the optimization of the reactor system results in a doubling of the maximum product concentrations for fermentation products. When a working electrode is polarized at -600 mV vs. Ag/AgCl, a shift from butyrate to acetone and butanol production is induced. This leads to an increased final solvent yield of Yᴀᴃᴇ = 0.202 gg⁻¹ (control 0.103 gg⁻¹), which is also reflected in a higher carbon efficiency of 37.6\% compared to 23.3\% (control) as well as a fourfold decrease in simplified E-factor to 0.43. The results are promising for further development of biobutanol production in bioelectrochemical systems in order to fulfil the principles of Green Chemistry.},
  language  = {en}
}
@inproceedings{FingerBraunBil2018,
  author    = {Finger, Felix and Braun, Carsten and Bil, Cees},
  title     = {An Initial Sizing Methodology for Hybrid-Electric Light Aircraft},
  series = {AIAA AVIATION Forum 2018 Aviation Technology, Integration, and Operations Conference, Atlanta, Georgia, June 25 - 29, 2018},
  booktitle = {AIAA AVIATION Forum 2018 Aviation Technology, Integration, and Operations Conference, Atlanta, Georgia, June 25 - 29, 2018},
  doi       = {10.2514/6.2018-4229},
  year      = {2018},
  language  = {en}
}
@article{HueningHeuermannWache2018,
  author    = {H{\"u}ning, Felix and Heuermann, Holger and Wache, Franz-Josef},
  title     = {Wireless CAN without WLAN or Bluetooth},
  series = {CAN Newsletter},
  journal   = {CAN Newsletter},
  number    = {December 2018},
  pages     = {44 -- 46},
  year      = {2018},
  abstract  = {In two developed concepts, dual-mode radio enables CAN participants to be integrated wirelessly into a CAN network. Constructed from a few components, a protocol-free, real-time transmission and thus transparent integration into CAN is provided.},
  language  = {en}
}
@inproceedings{BaaderReiswichBartschetal.2018,
  author    = {Baader, Fabian and Reiswich, M. and Bartsch, M. and Keller, D. and Tiede, E. and Keck, G. and Demircian, A. and Friedrich, M. and Dachwald, Bernd and Sch{\"u}ller, K. and Lehmann, R. and Chojetzki, R. and Durand, C. and Rapp, L. and Kowalski, Julia and F{\"o}rstner, R.},
  title     = {VIPER - Student research on extraterrestrical ice penetration technology},
  series = {Proceedings of the 2nd Symposium on Space Educational Activities},
  booktitle = {Proceedings of the 2nd Symposium on Space Educational Activities},
  pages     = {1 -- 6},
  year      = {2018},
  abstract  = {Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process.},
  language  = {en}
}
@article{WilsonDickieSchreiteretal.2018,
  author    = {Wilson, C. E. and Dickie, A. P. and Schreiter, K. and Wehr, R. and Wilson, E. M. and Bial, J. and Scheer, Nico and Wilson, I. D. and Riley, R. J.},
  title     = {The pharmacokinetics and metabolism of diclofenac in chimeric humanized and murinized FRG mice},
  series = {Archives of Toxicology},
  volume    = {92},
  journal   = {Archives of Toxicology},
  number    = {6},
  publisher = {Springer},
  issn      = {1432-0738},
  doi       = {10.1007/s00204-018-2212-1},
  pages     = {1953 -- 1967},
  year      = {2018},
  abstract  = {The pharmacokinetics of diclofenac were investigated following single oral doses of 10 mg/kg to chimeric liver humanized and murinized FRG and C57BL/6 mice. In addition, the metabolism and excretion were investigated in chimeric liver humanized and murinized FRG mice. Diclofenac reached maximum blood concentrations of 2.43 ± 0.9 µg/mL (n = 3) at 0.25 h post-dose with an AUCinf of 3.67 µg h/mL and an effective half-life of 0.86 h (n = 2). In the murinized animals, maximum blood concentrations were determined as 3.86 ± 2.31 µg/mL at 0.25 h post-dose with an AUCinf of 4.94 ± 2.93 µg h/mL and a half-life of 0.52 ± 0.03 h (n = 3). In C57BL/6J mice, mean peak blood concentrations of 2.31 ± 0.53 µg/mL were seen 0.25 h post-dose with a mean AUCinf of 2.10 ± 0.49 µg h/mL and a half-life of 0.51 ± 0.49 h (n = 3). Analysis of blood indicated only trace quantities of drug-related material in chimeric humanized and murinized FRG mice. Metabolic profiling of urine, bile and faecal extracts revealed a complex pattern of metabolites for both humanized and murinized animals with, in addition to unchanged parent drug, a variety of hydroxylated and conjugated metabolites detected. The profiles in humanized mice were different to those of both murinized and wild-type animals, e.g., a higher proportion of the dose was detected in the form of acyl glucuronide metabolites and much reduced amounts as taurine conjugates. Comparison of the metabolic profiles obtained from the present study with previously published data from C57BL/6J mice and humans revealed a greater, though not complete, match between chimeric humanized mice and humans, such that the liver humanized FRG model may represent a model for assessing the biotransformation of such compounds in humans.},
  language  = {en}
}
@inproceedings{BindzusBragard2018,
  author    = {Bindzus, Manuel and Bragard, Michael},
  title     = {Motivating Intuitive Understanding of the Switched Reluctance Machine in the Education of Undergraduate Students},
  series = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)},
  booktitle = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)},
  isbn      = {978-1-5386-6903-7},
  doi       = {10.1109/RTUCON.2018.8659870},
  pages     = {1 -- 6},
  year      = {2018},
  language  = {en}
}
@inproceedings{BragardHoekHoegenetal.2018,
  author    = {Bragard, Michael and Hoek, Hauke van and Hoegen, Anne von and Doncker, Rik W. De},
  title     = {Motivation-based Learning: Teaching Fundamentals of Electrical Engineering with an LED Spinning Top},
  series = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)},
  booktitle = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)},
  isbn      = {978-1-5386-6903-7},
  doi       = {10.1109/RTUCON.2018.8659810},
  pages     = {1 -- 6},
  year      = {2018},
  language  = {en}
}
@inproceedings{RuettersWeinheimerBragard2018,
  author    = {R{\"u}tters, Ren{\´e} and Weinheimer, Marius and Bragard, Michael},
  title     = {Teaching Control Theory with a Simplified Helicopter Model and a Classroom Fitting Hardware Test-Bench},
  series = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)},
  booktitle = {2018 IEEE 59th International Scientific Conference on Power and Electrical Engineering of Riga Technical University (RTUCON)},
  isbn      = {978-1-5386-6903-7},
  doi       = {10.1109/RTUCON.2018.8659871},
  year      = {2018},
  language  = {en}
}
@inproceedings{SerrorHenzeHacketal.2018,
  author    = {Serror, Martin and Henze, Martin and Hack, Sacha and Schuba, Marko and Wehrle, Klaus},
  title     = {Towards in-network security for smart homes},
  series = {13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018},
  booktitle = {13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018},
  isbn      = {978-145036448-5},
  doi       = {10.1145/3230833.3232802},
  pages     = {Article numer 3232802},
  year      = {2018},
  language  = {en}
}
@article{LauraDrechslerErdtetal.2018,
  author    = {Laura, C.O. and Drechsler, Klaus and Erdt, M. and Wesarg, S. and Bale, R.},
  title     = {Intervention assessment tool for primary tumors in the liver},
  series = {Current Directions in Biomedical Engineering},
  volume    = {4},
  journal   = {Current Directions in Biomedical Engineering},
  number    = {1},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2364-5504},
  doi       = {10.1515/cdbme-2018-0081},
  pages     = {337 -- 340},
  year      = {2018},
  abstract  = {After a liver tumor intervention the medical doctor has to compare both pre and postoperative CT acquisitions to ensure that all carcinogenic cells are destroyed. A correct assessment of the intervention is of vital importance, since it will reduce the probability of tumor recurrence. Some methods have been proposed to support the medical doctors during the assessment process, however, all of them focus on secondary tumors. In this paper a tool is presented that enables the outcome validation for both primary and secondary tumors. Therefore, a multiphase registration (preoperative arterial and portal phases) followed by a registration between the pre and postoperative CT images is carried out. The first registration is in charge of the primary tumors that are only visible in the arterial phase. The secondary tumors will be incorporated in the second registration step. Finally, the part of the tumor that was not covered by the necrosis is quantified and visualized. The method has been tested in 9 patients, with an average registration error of 1.41 mm.},
  language  = {en}
}
@article{HeinkeKnickerAlbracht2018,
  author    = {Heinke, Lars N. and Knicker, Axel J. and Albracht, Kirsten},
  title     = {Evaluation of passively induced shoulder stretch reflex using an isokinetic dynamometer in male overhead athletes},
  series = {Isokinetics and Exercise Science},
  volume    = {26},
  journal   = {Isokinetics and Exercise Science},
  number    = {4},
  publisher = {IOS Press},
  address   = {Amsterdam},
  issn      = {1878-5913},
  doi       = {10.3233/IES-184111},
  pages     = {265 -- 274},
  year      = {2018},
  abstract  = {BACKGROUND: Muscle stretch reflexes are widely considered to beneficially influence joint stability and power generation in the lower limbs. While in the upper limbs and especially in the muscles surrounding the shoulder joint such evidence is lacking. OBJECTIVE: To quantify the electromyographical response in the muscles crossing the shoulder of specifically trained overhead athletes to an anterior perturbation force. METHODS: Twenty healthy male participants performed six sets of different external shoulder rotation stretches on an isokinetic dynamometer over a range of amplitudes and muscle pre-activation moment levels. All stretches were applied with a dynamometer acceleration of 10,000∘/s2 and a velocity of 150∘/s. Electromyographical response was measured via sEMG. RESULTS: Consistent reflexes were not observed in all experimental conditions. The reflex latencies revealed a significant muscle main effect (F (2,228) = 99.31, p< 0.001; η2= 0.466; f= 0.934) and a pre-activation main effect (F (1,228) = 142.21, p< 0.001; η2= 0.384; f= 1.418). The stretch reflex amplitude yielded a significant pre-activation main effect (F (1,222) = 470.373, p< 0.001; η2= 0.679; f= 1.454). CONCLUSION: Short latency muscle reflexes showed a tendency to an anterior to posterior muscle recruitment whereby the main internal rotator muscles of the shoulder revealed the most consistent results.},
  language  = {en}
}
@inproceedings{GaoBabilonPfaffetal.2018,
  author    = {Gao, H. and Babilon, Katharina and Pfaff, Raphael and Gan, F. and Reich, A.},
  title     = {Model of wheel-rail contact for sanding and adhesion enhancement},
  series = {Proceedings of the 11th International Conference on Contact Mechanics and Wear of Rail/wheel Systems, CM 2018},
  booktitle = {Proceedings of the 11th International Conference on Contact Mechanics and Wear of Rail/wheel Systems, CM 2018},
  isbn      = {978-946186963-0},
  pages     = {314 -- 321},
  year      = {2018},
  language  = {en}
}
@article{FranzenPindersPfaffetal.2018,
  author    = {Franzen, Julius and Pinders, Erik and Pfaff, Raphael and Enning, Manfred},
  title     = {RailCrowd's virtual fleets: Make most of your asset data},
  series = {Deine Bahn},
  journal   = {Deine Bahn},
  number    = {9},
  publisher = {Bahn-Fachverlag},
  address   = {Berlin},
  issn      = {0948-7263},
  pages     = {11 -- 13},
  year      = {2018},
  abstract  = {For smaller railway operators or those with a diverse fleet, it can be difficult to collect sufficient data to improve maintenance programs. At the same time, new rules such as entity in charge of maintenance - ECM - regulations impose an additional workload by requiring a dedicated maintenance management system and specific reports. The RailCrowd platform sets out to facilitate compliance with ECM and similar regulations while at the same time pooling anonymised fleet data across operators to form virtual fleets, providing greater data insights.},
  language  = {en}
}
@inproceedings{PfaffMelcherFranzen2018,
  author    = {Pfaff, Raphael and Melcher, Karin and Franzen, Julian},
  title     = {Rare event simulation to optimise maintenance intervals of safety critical redundant subsystems},
  series = {Proceedings of the European Conference of the PHM Society},
  volume    = {4},
  booktitle = {Proceedings of the European Conference of the PHM Society},
  number    = {1},
  pages     = {1 -- 6},
  year      = {2018},
  language  = {en}
}
@inproceedings{ThurnGebhardt2018,
  author    = {Thurn, Laura and Gebhardt, Andreas},
  title     = {Strategy of Education on Materials for Students},
  series = {Conference Proceedings: „New Perspectives in Science Education"},
  booktitle = {Conference Proceedings: „New Perspectives in Science Education"},
  address   = {Florence, Italy},
  isbn      = {978-88-6292-976-9},
  pages     = {156 -- 161},
  year      = {2018},
  language  = {en}
}
@inproceedings{BueckingPfaffDirksmeier2018,
  author    = {B{\"u}cking, Henrik and Pfaff, Raphael and Dirksmeier, Roger},
  title     = {Sensor positioning and thermal model for condition monitoring of pressure gas reservoirs in vehicles},
  series = {Proceedings of the Fourth European Conference of the Prognostics and Health Management Society, Utrecht, Netherlands, 2018},
  booktitle = {Proceedings of the Fourth European Conference of the Prognostics and Health Management Society, Utrecht, Netherlands, 2018},
  pages     = {5 Seiten},
  year      = {2018},
  language  = {en}
}
@article{RauppSchmittWalzetal.2018,
  author    = {Raupp, Sebastian M. and Schmitt, Marcel and Walz, Anna-Lena and Diehm, Ralf and Hummel, Helga and Scharfer, Philip and Schabel, Wilhelm},
  title     = {Slot die stripe coating of low viscous fluids},
  series = {Journal of Coatings Technology and Research},
  volume    = {15},
  journal   = {Journal of Coatings Technology and Research},
  number    = {5},
  publisher = {Springer},
  issn      = {1935-3804},
  doi       = {10.1007/s11998-017-0039-y},
  pages     = {899 -- 911},
  year      = {2018},
  abstract  = {Slot die coating is applied to deposit thin and homogenous films in roll-to-roll and sheet-to-sheet applications. The critical step in operation is to choose suitable process parameters within the process window. In this work, we investigate an upper limit for stripe coatings. This maximum film thickness is characterized by stripe merging which needs to be avoided in a stable process. It is shown that the upper limit reduces the process window for stripe coatings to a major extent. As a result, stripe coatings at large coating gaps and low viscosities are only possible for relatively thick films. Explaining the upper limit, a theory of balancing the side pressure in the gap region in the cross-web direction has been developed.},
  language  = {en}
}
@inproceedings{WiesenEngemannLimpertetal.2018,
  author    = {Wiesen, Patrick and Engemann, Heiko and Limpert, Nicolas and Kallweit, Stephan},
  title     = {Learning by Doing - Mobile Robotics in the FH Aachen ROS Summer School},
  series = {European Robotics Forum 2018, TRROS18 Workshop},
  booktitle = {European Robotics Forum 2018, TRROS18 Workshop},
  pages     = {47 -- 58},
  year      = {2018},
  language  = {en}
}
@inproceedings{BirklDiendorferKernetal.2018,
  author    = {Birkl, Josef and Diendorfer, Gerhard and Kern, Alexander and Thern, Stephan},
  title     = {Extremely high lightning peak currents},
  series = {34th International Conference on Ligntning Protection, 02-07 September 2018},
  booktitle = {34th International Conference on Ligntning Protection, 02-07 September 2018},
  isbn      = {978-1-5386-6635-7},
  pages     = {7 Seiten},
  year      = {2018},
  language  = {en}
}
@article{PuppeGiulianoFrantzetal.2018,
  author    = {Puppe, Michael and Giuliano, Stefano and Frantz, Cathy and Uhlig, Ralf and Schumacher, Ralph and Ibraheem, Wagdi and Schmalz, Stefan and Waldmann, Barbara and Guder, Christoph and Peter, Dennis and Schwager, Christian and Teixeira Boura, Cristiano Jos{\´e} and Alexopoulos, Spiros and Spiegel, Michael and Wortmann, J{\"u}rgen and Hinrichs, Matthias and Engelhard, Manfred and Aust, Michael},
  title     = {Techno-economic optimization of molten salt solar tower plants},
  series = {AIP Conference Proceedings art.no. 040033},
  volume    = {2033},
  journal   = {AIP Conference Proceedings art.no. 040033},
  number    = {Issue 1},
  publisher = {AIP Publishing},
  address   = {Melville, NY},
  doi       = {10.1063/1.5067069},
  year      = {2018},
  abstract  = {In this paper the results of a techno-economic analysis of improved and optimized molten salt solar tower plants (MSSTP plants) are presented. The potential improvements that were analyzed include different receiver designs, different designs of the HTF-system and plant control, increased molten salt temperatures (up to 640°C) and multi-tower systems. Detailed technological and economic models of the solar field, solar receiver and high temperature fluid system (HTF-system) were developed and used to find potential improvements compared to a reference plant based on Solar Two technology and up-to-date cost estimations. The annual yield model calculates the annual outputs and the LCOE of all variants. An improved external tubular receiver and improved HTF-system achieves a significant decrease of LCOE compared to the reference. This is caused by lower receiver cost as well as improvements of the HTF-system and plant operation strategy, significantly reducing the plant own consumption. A novel star receiver shows potential for further cost decrease. The cavity receiver concepts result in higher LCOE due to their high investment cost, despite achieving higher efficiencies. Increased molten salt temperatures seem possible with an adapted, closed loop HTF-system and achieve comparable results to the original improved system (with 565°C) under the given boundary conditions. In this analysis all multi tower systems show lower economic viability compared to single tower systems, caused by high additional cost for piping connections and higher cost of the receivers. REFERENCES},
  language  = {en}
}
@inproceedings{GorzalkaDahlkeGoettscheetal.2018,
  author    = {Gorzalka, Philip and Dahlke, Dennis and G{\"o}ttsche, Joachim and Israel, Martin and Patel, Dhruvkumar and Prahl, Christoph and Schmiedt, Jacob Estevam and Frommholz, Dirk and Hoffschmidt, Bernhard and Linkiewicz, Magdalena},
  title     = {Building Tomograph-From Remote Sensing Data of Existing Buildings to Building Energy Simulation Input},
  series = {EBC, Annex 71, Fifth expert meeting, October 17-19, 2018, Innsbruck, Austria},
  booktitle = {EBC, Annex 71, Fifth expert meeting, October 17-19, 2018, Innsbruck, Austria},
  pages     = {17 Seiten},
  year      = {2018},
  language  = {en}
}
@inproceedings{GoettenHavermannBraunetal.2018,
  author    = {G{\"o}tten, Falk and Havermann, Marc and Braun, Carsten and Gomez, Francisco and Bil, Cees},
  title     = {On the Applicability of Empirical Drag Estimation Methods for Unmanned Air Vehicle Design Read More: https://arc.aiaa.org/doi/10.2514/6.2018-3192},
  series = {2018 Aviation Technology, Integration, and Operations Conference, AIAA AVIATION Forum},
  booktitle = {2018 Aviation Technology, Integration, and Operations Conference, AIAA AVIATION Forum},
  issn      = {1533-385X},
  doi       = {10.2514/6.2018-3192},
  pages     = {Article 3192},
  year      = {2018},
  language  = {en}
}
@inproceedings{GrundmannBauerBorchersetal.2018,
  author    = {Grundmann, Jan Thimo and Bauer, Waldemar and Borchers, Kai and Dumont, Etienne and Grimm, Christian D. and Ho, Tra-Mi and Jahnke, Rico and Lange, Caroline and Maiwald, Volker and Mikulz, Eugen and Quantius, Dominik and Reershemius, Siebo and Renger, Thomas and Riemann, Johannes and Sasaki, Kaname and Seefeldt, Patric and Spietz, Peter and Spr{\"o}witz, Tom and Toth, Norbert and Wejmo, Elisabet and Biele, Jens and Krause, Christian and Cerotti, Matteo and Peloni, Alessandro and Dachwald, Bernd},
  title     = {Small Spacecraft Solar Sailing for Small Solar System Body Multiple Rendezvous and Landing},
  series = {2018 IEEE Aerospace Conference : 3-10 March 2018},
  booktitle = {2018 IEEE Aerospace Conference : 3-10 March 2018},
  isbn      = {978-1-5386-2014-4},
  pages     = {20 Seiten},
  year      = {2018},
  language  = {en}
}
@inproceedings{WaldmannVeraDachwaldetal.2018,
  author    = {Waldmann, Christoph and Vera, Jean-Pierre de and Dachwald, Bernd and Strasdeit, Henry and Sohl, Frank and Hanff, Hendrik and Kowalski, Julia and Heinen, Dirk and Macht, Sabine and Bestmann, Ulf and Meckel, Sebastian and Hildebrandt, Marc and Funke, Oliver and Gehrt, Jan-J{\"o}ran},
  title     = {Search for life in ice-covered oceans and lakes beyond Earth},
  series = {2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761},
  booktitle = {2018 IEEE/OES Autonomous Underwater Vehicle Workshop, Proceedings November 2018, Article number 8729761},
  doi       = {10.1109/AUV.2018.8729761},
  year      = {2018},
  abstract  = {The quest for life on other planets is closely connected with the search for water in liquid state. Recent discoveries of deep oceans on icy moons like Europa and Enceladus have spurred an intensive discussion about how these waters can be accessed. The challenge of this endeavor lies in the unforeseeable requirements on instrumental characteristics both with respect to the scientific and technical methods. The TRIPLE/nanoAUV initiative is aiming at developing a mission concept for exploring exo-oceans and demonstrating the achievements in an earth-analogue context, exploring the ocean under the ice shield of Antarctica and lakes like Dome-C on the Antarctic continent.},
  language  = {en}
}
@incollection{SchoeningWagnerPoghossianetal.2018,
  author    = {Sch{\"o}ning, Michael Josef and Wagner, Torsten and Poghossian, Arshak and Miyamoto, K.I. and Werner, C.F. and Krause, S. and Yoshinobu, T.},
  title     = {Light-addressable potentiometric sensors for (bio-)chemical sensing and imaging},
  series = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7},
  booktitle = {Encyclopedia of Interfacial Chemistry: Surface Science and Electrochemistry. Vol. 7},
  publisher = {Elsevier},
  address   = {Amsterdam},
  isbn      = {9780128097397},
  pages     = {295 -- 308},
  year      = {2018},
  language  = {en}
}
@inproceedings{KromeSander2018,
  author    = {Krome, Cornelia and Sander, Volker},
  title     = {Time series analysis with apache spark and its applications to energy informatics},
  series = {Proceedings of the 7th DACH+ Conference on Energy Informatics},
  booktitle = {Proceedings of the 7th DACH+ Conference on Energy Informatics},
  doi       = {10.1186/s42162-018-0043-1},
  year      = {2018},
  abstract  = {In energy economy forecasts of different time series are rudimentary. In this study, a prediction for the German day-ahead spot market is created with Apache Spark and R. It is just an example for many different applications in virtual power plant environments. Other examples of use as intraday price processes, load processes of machines or electric vehicles, real time energy loads of photovoltaic systems and many more time series need to be analysed and predicted. This work gives a short introduction into the project where this study is settled. It describes the time series methods that are used in energy industry for forecasts shortly. As programming technique Apache Spark, which is a strong cluster computing technology, is utilised. Today, single time series can be predicted. The focus of this work is on developing a method to parallel forecasting, to process multiple time series simultaneously with R and Apache Spark.},
  language  = {en}
}
@phdthesis{Bhattarai2018,
  author    = {Bhattarai, Aroj},
  title     = {Constitutive modeling of female pelvic floor dysfunctions and reconstructive surgeries using prosthetic mesh implants},
  isbn      = {978-3-9818074-8-6},
  doi       = {10.17185/duepublico/70340},
  pages     = {192 S.},
  year      = {2018},
  language  = {en}
}
@article{DigelWehlitzKayseretal.2018,
  author    = {Digel, Ilya and Wehlitz, V. and Kayser, Peter and Figiel-Lange, A. and Bassam, R. and Rundstedt, F. von},
  title     = {Suspension depletion approach for exemption of infected Solanum jasminoides cells from pospiviroids},
  series = {Plant Pathology},
  volume    = {67},
  journal   = {Plant Pathology},
  number    = {2},
  publisher = {Wiley},
  address   = {Oxford},
  issn      = {1365-3059},
  doi       = {10.1111/ppa.12750},
  pages     = {358 -- 365},
  year      = {2018},
  abstract  = {Despite numerous studies, viroid elimination from infected plants remains a very challenging task. This study introduces for the first time a novel 'suspension depletion' approach for exemption of Solanum jasminoides plants from viroids. The proposed method implies initial establishment of suspension cultures of the infected plant cells. The suspended cells were then physically treated (mild thermotherapy, 33 °C), which presumably delayed the replication of the viroid. The viroid concentration in the treated biomass was monitored weekly using pospiviroid-specific PCR. After 10-12 weeks of continuous treatment, a sufficient decrease in viroid concentration was observed such that the infection became undetectable by PCR. The treated single cells then gave rise to microcolonies on a solid culture medium and the obtained viroid-negative clones were further promoted to regenerate into viroid-free plants. Three years of accumulated experimental data suggests feasibility, broad applicability, and good efficacy of the proposed approach.},
  language  = {en}
}
@article{EngelmannRoethEberbecketal.2018,
  author    = {Engelmann, Ulrich M. and Roeth, Anjali A.J. and Eberbeck, Dietmar and Buhl, Eva Miriam and Neumann, Ulf Peter and Schmitz-Rode, Thomas and Slabu, Ioana},
  title     = {Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells},
  series = {Scientific Reports},
  volume    = {8},
  journal   = {Scientific Reports},
  number    = {1},
  publisher = {Springer Nature},
  address   = {Cham},
  issn      = {2045-2322},
  doi       = {10.1038/s41598-018-31553-9},
  pages     = {Article number 13210},
  year      = {2018},
  abstract  = {Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95\% was achieved by depositing an intracellular total thermal energy with about 50\% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86\% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65\% after MNP were internalized inside cells.},
  language  = {en}
}
@article{EngelmannBuhlDraacketal.2018,
  author    = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Draack, Sebastian and Viereck, Thilo and Frank, and Schmitz-Rode, Thomas and Slabu, Ioana},
  title     = {Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications},
  series = {IEEE Magnetic Letters},
  volume    = {9},
  journal   = {IEEE Magnetic Letters},
  number    = {Article number 8519617},
  publisher = {IEEE},
  address   = {New York, NY},
  issn      = {1949-307X},
  doi       = {10.1109/LMAG.2018.2879034},
  year      = {2018},
  abstract  = {Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23\% for agglomerated MNP in suspension and a decrease by up to 28\% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.},
  language  = {en}
}