@inproceedings{GiresiniButenwegAndreinietal.2014,
  author    = {Giresini, Linda and Butenweg, Christoph and Andreini, M. and De Falco, A. and Sassu, M.},
  title     = {Macro-elements identification in historic chapels: the case of St. Venerio Chapel in Reggiolo - Emilia Romagna},
  series = {9th International Conference on Structural Analyses of Historical Conctruction, 14 - 17 October, 2014, Mexico City},
  booktitle = {9th International Conference on Structural Analyses of Historical Conctruction, 14 - 17 October, 2014, Mexico City},
  organization    = {International Conference on Structural Analyses of Historical Conctructions <9, 2014, Mexico City>},
  pages     = {1 -- 12},
  year      = {2014},
  language  = {en}
}
@article{AkimbekovDigelOHerasetal.2014,
  author    = {Akimbekov, Nuraly S. and Digel, Ilya and O´Heras, C. and Tastambek, K.T. and Savitskaya, I.S. and Ualyeva, P.S. and Mansurov, Z.A. and Zhubanova, A.A.},
  title     = {Adsorption of bacterial lipopolysaccharides on carbonized rice husks obtained in the batch experiments},
  series = {Experimental Biology},
  volume    = {60},
  journal   = {Experimental Biology},
  number    = {1/2},
  publisher = {Al-Farabi Kazakh National University},
  address   = {Almaty},
  issn      = {1563-0218},
  pages     = {144 -- 148},
  year      = {2014},
  abstract  = {The scope of this study is the measurement of endotoxin adsorption rate for carbonized rice husk. It showed good adsorption properties for LPS. During the batch experiments, several techniques were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics.},
  language  = {en}
}
@article{FateriGebhardtThuemmleretal.2014,
  author    = {Fateri, Miranda and Gebhardt, Andreas and Th{\"u}mmler, Stefan and Thurn, Laura},
  title     = {Experimental investigation on selective laser melting of glass},
  series = {Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014},
  volume    = {56 (2014)},
  journal   = {Physics procedia : 8th International Conference on Laser Assisted Net Shape Engineering LANE 2014},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1875-3892 (E-Journal); 1875-3884 (Print)},
  doi       = {10.1016/j.phpro.2014.08.118},
  pages     = {357 -- 364},
  year      = {2014},
  language  = {en}
}
@article{ArinkinDigelPorstetal.2014,
  author    = {Arinkin, Vladimir and Digel, Ilya and Porst, Dariusz and Temiz Artmann, Ayseg{\"u}l and Artmann, Gerhard},
  title     = {Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application},
  series = {BMC bioinformatics},
  volume    = {15},
  journal   = {BMC bioinformatics},
  number    = {55},
  issn      = {1471-2105},
  doi       = {10.1186/1471-2105-15-55},
  pages     = {1 -- 8},
  year      = {2014},
  abstract  = {Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1\% and reached 100\% in one of the best ANN.},
  language  = {en}
}
@incollection{DachwaldBoehnhardtBrojetal.2014,
  author    = {Dachwald, Bernd and Boehnhardt, Herrmann and Broj, Ulrich and Geppert, Ulrich R. M. E. and Grundmann, Jan-Thimo and Seboldt, Wolfgang and Seefeldt, Patric and Spietz, Peter and Johnson, Les and K{\"u}hrt, Ekkehard and Mottola, Stefano and Macdonald, Malcolm and McInnes, Colin R. and Vasile, Massimiliano and Reinhard, Ruedeger},
  title     = {Gossamer roadmap technology reference study for a multiple NEO Rendezvous Mission},
  series = {Advances in solar sailing},
  booktitle = {Advances in solar sailing},
  publisher = {Springer},
  address   = {Berlin [u.a.]},
  isbn      = {978-3-642-34906-5 (Print) ; 978-3-642-34907-2 (E-Book)},
  pages     = {211 -- 226},
  year      = {2014},
  abstract  = {A technology reference study for a multiple near-Earth object (NEO) rendezvous mission with solar sailcraft is currently carried out by the authors of this paper. The investigated mission builds on previous concepts, but adopts a strong micro-spacecraft philosophy based on the DLR/ESA Gossamer technology. The main scientific objective of the mission is to explore the diversity of NEOs. After direct interplanetary insertion, the solar sailcraft should—within less than 10 years—rendezvous three NEOs that are not only scientifically interesting, but also from the point of human spaceight and planetary defense. In this paper, the objectives of the study are outlined and a preliminary potential mission profile is presented.},
  language  = {en}
}
@article{GollandEngling2014,
  author    = {Golland, Alexander and Engling, Christoph},
  title     = {a-i3/BSI Symposium 2014: Sicherheit von Daten und Identit{\"a}ten angesichts NSA und Big Data},
  series = {DSB Datenschutz-Berater},
  volume    = {38},
  journal   = {DSB Datenschutz-Berater},
  number    = {7-8},
  publisher = {DFV Mediengruppe},
  address   = {Frankfurt a.M.},
  isbn      = {0170-7256},
  pages     = {165 -- 166},
  year      = {2014},
  language  = {de}
}
@misc{AlKaidyUlberTippkoetter2014,
  author    = {Al-Kaidy, H. and Ulber, Roland and Tippk{\"o}tter, Nils},
  title     = {Eine Plattform-Technologie f{\"u}r die automatisierte Reaktionsf{\"u}hrung in magnetisierbaren mikrofluidischen Tropfen},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450424},
  pages     = {1419 -- 1420},
  year      = {2014},
  abstract  = {{\"U}blicherweise werden biotechnologische Reaktionssysteme im mikrofluidischen Maßstab in vorstrukturierten Bauteilen oder mit auf Wellplatten basierenden Robotersystemen realisiert. In dem hier vorgestellten System werden chemische oder biologische Reaktionen mit magnetischen Mikroreaktoren (MR) durchgef{\"u}hrt, bei denen hydrophobe magnetische Mikropartikel einen w{\"a}ssrigen Kern umschließen. Solche MR bieten eine gute Kontrolle der Reaktionsbedingungen, eine verbesserte Sicherheit und Portabilit{\"a}t. Die neue Plattformtechnologie erm{\"o}glicht die zweidimensionale Bewegung der magnetischen MR auf einer planaren Ebene. Oberhalb oder unterhalb der Plattform werden Magnetfeldgradienten zum Manipulieren und Bewegen eines oder mehrerer magnetischer MR erzeugt. Die optimal auf die MR wirkenden magnetischen Kr{\"a}fte werden experimentell ermittelt und simuliert. Die Aktivierung der Magnetfelder wird automatisiert durch elektrische Spulen mit Eisenkern bzw. Neodymmagnet gesteuert. Angewendet wurde das System beim reversiblen {\"O}ffnen von MR, um z. B. Reaktionspartner in den w{\"a}ssrigen Kern zu injizieren oder Proben zu entnehmen. Ferner wurde Lac-case A und b-Glucosidase auf einer Quarzglasoberfl{\"a}che immobilisiert und mit einem MR zum Reagieren gebracht. Weiterhin wurden MR fusioniert und so ein w{\"a}ssriger Kern bestehend aus Laccase mit einem aus dem entsprechenden Substrat Syringaldazin vereint.},
  language  = {de}
}
@article{KronhardtAlexopoulosReisseletal.2014,
  author    = {Kronhardt, Valentina and Alexopoulos, Spiros and Reißel, Martin and Sattler, Johannes Christoph and Hoffschmidt, Bernhard and H{\"a}nel, Matthias and Doerbeck, Till},
  title     = {High-temperature thermal storage system for solar tower power plants with open-volumetric air receiver simulation and energy balancing of a discretized model},
  series = {Energy procedia},
  volume    = {49},
  journal   = {Energy procedia},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1876-6102 (E-Journal) ; 1876-6102 (Print)},
  doi       = {10.1016/j.egypro.2014.03.094},
  pages     = {870 -- 877},
  year      = {2014},
  abstract  = {This paper describes the modeling of a high-temperature storage system for an existing solar tower power plant with open volumetric receiver technology, which uses air as heat transfer medium (HTF). The storage system model has been developed in the simulation environment Matlab/Simulink®. The storage type under investigation is a packed bed thermal energy storage system which has the characteristics of a regenerator. Thermal energy can be stored and discharged as required via the HTF air. The air mass flow distribution is controlled by valves, and the mass flow by two blowers. The thermal storage operation strategy has a direct and significant impact on the energetic and economic efficiency of the solar tower power plants.},
  language  = {en}
}
@misc{StadtmuellerTippkoetterUlber2014,
  author    = {Stadtm{\"u}ller, R. and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Produktion von einzelstr{\"a}ngigen DNA-Makronukleotiden},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450372},
  pages     = {1403},
  year      = {2014},
  abstract  = {In der Biotechnologie stellt Einzelstrang-DNA (ssDNA) eine Schl{\"u}sselrolle dar und fungiert z. B. als Baustein f{\"u}r die nanoskalige Feinmechanik oder als Affinit{\"a}tsligand, ein sog. Aptamer. Hinsichtlich der industriellen Verwendung bieten Aptamere im Vergleich zu Antik{\"o}rpern viele Vorteile, wie z. B. eine gute Renaturierung bzw. die Selektion f{\"u}r cytotoxische Molek{\"u}le. Aktuell w{\"a}chst die Nachfrage f{\"u}r chim{\"a}re Aptamere von bis zu 200 n, um die simultane Bindung bzw. die Modifikation mehrerer Molek{\"u}le zu realisieren. Bis heute wird ssDNA mittels einer sequentiellen Synthese hergestellt, die eine Effizienz von ca. 99,5 \% je Zyklus und bereits bei einer Produktl{\"a}nge von 100 n nur noc hAusbeuten von max. 60 \% zeigt. Um dem Bedarf an ssDNA im Bereich > 100 n zu entsprechen, wurden zwei enzymatische Verfahren zur Produktion dieser Makronukleotide entworfen. Die erste Technik basiert auf einerFestphasen-PCR und erm{\"o}glicht sowohlein Primer- als auch ein Templatrecycling. Das zweite Verfahren beruht auf einer Plasmidbasierten In-vivo-Amplifikation, der sog. AptaGENE®-Technologie. In einer einzigen Klonierung werden bis zu 100 Kopien des Monomers in einen Vektor kloniert. Nach einer Transformation folgt der regul{\"a}re Produktionsprozess in Form einer Kultivierung, Plasmidpr{\"a}paration und sequenziellen Aufarbeitung von bis zu 6 · 10¹⁵ Makronukleotiden pro Milliliter Fermentationsvolumen.},
  language  = {de}
}
@inproceedings{RosinHenneboehlButenweg2014,
  author    = {Rosin, Julia and Henneb{\"o}hl, Benedickt and Butenweg, Christoph},
  title     = {Global buckling analysis of cylindrical liquid storage tanks under earthquake loading},
  series = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6},
  booktitle = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6},
  publisher = {Curran Associates, Inc.},
  address   = {Red Hook, NY},
  organization    = {European Conference on Earthquake Engineering and Seismology <2, 2014, Istanbul>},
  isbn      = {978-1-5108-1021-1},
  pages     = {5270 -- 5281},
  year      = {2014},
  language  = {en}
}
@incollection{NiemuellerEwertReuteretal.2014,
  author    = {Niem{\"u}ller, Tim and Ewert, Daniel and Reuter, Sebastian and Ferrein, Alexander and Jeschke, Sabina and Lakemeyer, Gerhard},
  title     = {RoboCup logistics league sponsored by festo: A competitive factory automation testbed},
  series = {RoboCup 2013: Robot World Cup XVII : Eindhoven; Netherlands; 1 July 2013 through 1 July 2013. (Lecture notes in computer science ; 8371)},
  booktitle = {RoboCup 2013: Robot World Cup XVII : Eindhoven; Netherlands; 1 July 2013 through 1 July 2013. (Lecture notes in computer science ; 8371)},
  publisher = {Springer},
  address   = {Berlin},
  organization    = {RoboCup International Symposium <17, 2013, Eindhoven>},
  isbn      = {978-3-662-44467-2 (Print) 978-3-662-44468-9 (Online)},
  pages     = {336 -- 347},
  year      = {2014},
  abstract  = {A new trend in automation is to deploy so-called cyber-physical systems (CPS) which combine computation with physical processes. The novel RoboCup Logistics League Sponsored by Festo (LLSF) aims at such CPS logistic scenarios in an automation setting. A team of robots has to produce products from a number of semi-finished products which they have to machine during the game. Different production plans are possible and the robots need to recycle scrap byproducts. This way, the LLSF is a very interesting league offering a number of challenging research questions for planning, coordination, or communication in an application-driven scenario. In this paper, we outline the objectives of the LLSF and present steps for developing the league further towards a benchmark for logistics scenarios for CPS. As a major milestone we present the new automated referee system which helps in governing the game play as well as keeping track of the scored points in a very complex factory scenario.},
  language  = {en}
}
@misc{TippkoetterSiekerWiesenetal.2014,
  author    = {Tippk{\"o}tter, Nils and Sieker, T. and Wiesen, S. and Duwe, A. and Roth, J. and Ulber, Roland},
  title     = {Simultane Saccharifizierung und Fermentierung (SSF) sowie Produktion von Aceton, Butanol, Ethanol (ABE) und Dicarbons{\"a}uren aus technischer Cellulose},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450297},
  pages     = {1518},
  year      = {2014},
  abstract  = {Technische Cellulose wurde als m{\"o}glicher Rohstoff zur fermentativen Produktbildung untersucht. Hierf{\"u}r wird Cellulose in der Lignocellulose-Bioraffinerie hergestellt und daraus Hydrolysat gewonnen. Die Pr{\"u}fung der technischen Hydrolysate als Substrate erfolgte anhand eines breiten Spektrums an Bioprodukten, von Kraftstoffen wie Ethanolund Butanol, bis zu den Dicarbons{\"a}uren Itacon- und Bernsteins{\"a}ure. Dabei werden Bakterien, Hefen und Pilze als Produktionsorganismen eingesetzt. Die einzelnen Herstellverfahren stellen unterschiedliche Anforderungen an die Substrathandhabung. Im Fall der Ethanol- und Butanol-Gewinnung kann eine simultane Saccharifizierung und Fermentierung (SSF) durchgef{\"u}hrt werden. Aufgrund der Produkttoxizit{\"a}t erfordert die Butanol-Herstellung dabei eine In-situ-Produktabtrennung durch L{\"o}semittelimpr{\"a}gnierte Partikel. Die Herstellung der beiden Dicarbons{\"a}uren unterscheidet sich in der Sensitivit{\"a}t der verwendeten Mikroorganismen gegen{\"u}ber Inhibitoren, die in Spuren im Hydrolysat enthalten sind. Die Bernteins{\"a}urebildung mit Actinobacillussuccinogenes kann mit unbehandeltem Hydrolysat erfolgen. Dagegen erfordert die Gewinnung von Itacons{\"a}ure mit A. terreus eine Detoxifizierung des Hydrolysats. Insgesamt konnte gezeigt werden, dass s{\"a}mtliche Bioraffinerie-Hydrolysate als Substrate f{\"u}r unterschiedliche Fermentationen geeignet sind.},
  language  = {de}
}
@article{HandtkeSchroeterJuergenetal.2014,
  author    = {Handtke, Stefan and Schroeter, Rebecca and J{\"u}rgen, Britta and Methling, Karen and Schl{\"u}ter, Rabea and Albrecht, Dirk and Hijum, Sacha A. F. T. van and Bongaerts, Johannes and Maurer, Karl-Heinz and Lalk, Michael and Schweder, Thomas and Hecker, Michael and Voigt, Birgit},
  title     = {Bacillus pumilus reveals a remarkably high resistance to hydrogen peroxide provoked oxidative stress},
  series = {PLOS one},
  volume    = {9},
  journal   = {PLOS one},
  number    = {1},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0085625},
  pages     = {e85625},
  year      = {2014},
  abstract  = {Bacillus pumilus is characterized by a higher oxidative stress resistance than other comparable industrially relevant Bacilli such as B. subtilis or B. licheniformis. In this study the response of B. pumilus to oxidative stress was investigated during a treatment with high concentrations of hydrogen peroxide at the proteome, transcriptome and metabolome level. Genes/proteins belonging to regulons, which are known to have important functions in the oxidative stress response of other organisms, were found to be upregulated, such as the Fur, Spx, SOS or CtsR regulon. Strikingly, parts of the fundamental PerR regulon responding to peroxide stress in B. subtilis are not encoded in the B. pumilus genome. Thus, B. pumilus misses the catalase KatA, the DNA-protection protein MrgA or the alkyl hydroperoxide reductase AhpCF. Data of this study suggests that the catalase KatX2 takes over the function of the missing KatA in the oxidative stress response of B. pumilus. The genome-wide expression analysis revealed an induction of bacillithiol (Cys-GlcN-malate, BSH) relevant genes. An analysis of the intracellular metabolites detected high intracellular levels of this protective metabolite, which indicates the importance of bacillithiol in the peroxide stress resistance of B. pumilus.},
  language  = {en}
}
@incollection{TranStaat2014,
  author    = {Tran, Thanh Ngoc and Staat, Manfred},
  title     = {Shakedown analysis of Reissner-Mindlin plates using the edge-based smoothed finite element method},
  series = {Direct methods for limit states in structures and materials / Dieter Weichert ; Alan Ponter, ed.},
  booktitle = {Direct methods for limit states in structures and materials / Dieter Weichert ; Alan Ponter, ed.},
  publisher = {Springer},
  address   = {Dordrecht [u.a.]},
  isbn      = {978-94-007-6826-0 (Print) 978-94-007-6827-7 (Online)},
  doi       = {10.1007/978-94-007-6827-7_5},
  pages     = {101 -- 117},
  year      = {2014},
  abstract  = {This paper concerns the development of a primal-dual algorithm for limit and shakedown analysis of Reissner-Mindlin plates made of von Mises material. At each optimization iteration, the lower bound of the shakedown load multiplier is calculated simultaneously with the upper bound using the duality theory. An edge-based smoothed finite element method (ES-FEM) combined with the discrete shear gap (DSG) technique is used to improve the accuracy of the solutions and to avoid the transverse shear locking behaviour. The method not only possesses all inherent features of convergence and accuracy from ES-FEM, but also ensures that the total number of variables in the optimization problem is kept to a minimum compared with the standard finite element formulation. Numerical examples are presented to demonstrate the effectiveness of the present method.},
  language  = {en}
}
@book{Heuermann2014,
  author    = {Heuermann, Holger},
  title     = {Mikrowellentechnik},
  edition   = {4. Aufl.},
  pages     = {[Elektronische Ressource] IX, 225 S. ; graph. Darst.},
  year      = {2014},
  language  = {de}
}
@inproceedings{DuongStaat2014,
  author    = {Duong, Minh Tuan and Staat, Manfred},
  title     = {A face-based smoothed finite element method for hyperelastic models and tissue growth},
  series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  editor    = {Onate, E.},
  organization    = {World Congress on Computational Mechanics <11, 2014, Barcelona>},
  pages     = {1 -- 12},
  year      = {2014},
  language  = {en}
}
@inproceedings{KallweitFerreinScholletal.2014,
  author    = {Kallweit, Stephan and Ferrein, Alexander and Scholl, Ingrid and Reichert, Walter},
  title     = {Mobile Autonome Systeme in der Lehre, am Beispiel der ROS Summer School},
  series = {Tagungsband AALE 2014 : das Forum f{\"u}r Fachleute der Automatisierungstechnik aus Hochschulen und Wirtschaft ; 11. Fachkonferenz, Regensburg ; [11. Konferenz f{\"u}r Angewandte Automatisierungstechnik in Lehre und Entwicklung / Ostbayerische Technische Hochschule Regensburg; VFAALE, Verein der Freunde und F{\"o}rderer der Angewandten Automatisierungstechnik]},
  booktitle = {Tagungsband AALE 2014 : das Forum f{\"u}r Fachleute der Automatisierungstechnik aus Hochschulen und Wirtschaft ; 11. Fachkonferenz, Regensburg ; [11. Konferenz f{\"u}r Angewandte Automatisierungstechnik in Lehre und Entwicklung / Ostbayerische Technische Hochschule Regensburg; VFAALE, Verein der Freunde und F{\"o}rderer der Angewandten Automatisierungstechnik]},
  publisher = {Dt. Industrieverl.},
  address   = {M{\"u}nchen},
  isbn      = {978-3-8356-7142-3},
  pages     = {157 -- 163},
  year      = {2014},
  language  = {de}
}
@article{FrotscherStaat2014,
  author    = {Frotscher, Ralf and Staat, Manfred},
  title     = {Stresses produced by different textile mesh implants in a tissue equivalent},
  series = {BioNanoMaterials},
  volume    = {15},
  journal   = {BioNanoMaterials},
  number    = {1-2},
  publisher = {De Gruyter},
  address   = {Berlin},
  issn      = {2191-4672 (E-Journal); 2193-066X (E-Journal); 0011-8656 (Print); 1616-0177 (Print); 2193-0651 (Print)},
  doi       = {10.1515/bnm-2014-0003},
  pages     = {25 -- 30},
  year      = {2014},
  abstract  = {Two single-incision mini-slings used for treating urinary incontinence in women are compared with respect to the stresses they produce in their surrounding tissue. In an earlier paper we experimentally observed that these implants produce considerably different stress distributions in a muscle tissue equivalent. Here we perform 2D finite element analyses to compare the shear stresses and normal stresses in the tissue equivalent for the two meshes and to investigate their failure behavior. The results clearly show that the Gynecare TVT fails for increasing loads in a zipper-like manner because it gradually debonds from the surrounding tissue. Contrary to that, the tissue at the ends of the DynaMesh-SIS direct may rupture but only at higher loads. The simulation results are in good agreement with the experimental observations thus the computational model helps to interpret the experimental results and provides a tool for qualitative evaluation of mesh implants.},
  language  = {en}
}
@inproceedings{GoettscheRoether2014,
  author    = {G{\"o}ttsche, Joachim and R{\"o}ther, Sascha},
  title     = {Science College Overbach - Innovatives Bildungszentrum in J{\"u}lich-Barmen},
  series = {18. Internationale Passivhaustagung, Aachen, April 2014},
  booktitle = {18. Internationale Passivhaustagung, Aachen, April 2014},
  pages     = {6 Seiten},
  year      = {2014},
  abstract  = {Preprint der Autoren},
  language  = {de}
}
@inproceedings{JanotteFecklerKoetteretal.2014,
  author    = {Janotte, N. and Feckler, G. and K{\"o}tter, Jens and Decker, Stefan and Herrmann, Ulf and Schmitz, Mark and L{\"u}pfert, E.},
  title     = {Dynamic performance evaluation of the HelioTrough® collector demonstration loop : towards a new benchmark in parabolic trough qualification},
  series = {SolarPACES International Conference 2013, Las Vegas, Nevada, USA, 17 - 20 September 2013 : [proceedings]. - Pt. 1. - (Energy procedia ; 49)},
  booktitle = {SolarPACES International Conference 2013, Las Vegas, Nevada, USA, 17 - 20 September 2013 : [proceedings]. - Pt. 1. - (Energy procedia ; 49)},
  publisher = {Curran},
  address   = {Red Hook, NY},
  isbn      = {978-1-63266-904-9},
  issn      = {1876-6102},
  doi       = {10.1016/j.egypro.2014.03.012},
  pages     = {109 -- 117},
  year      = {2014},
  language  = {en}
}
@incollection{KnottSofroniaGerressenetal.2014,
  author    = {Knott, Thomas C. and Sofronia, Raluca E. and Gerressen, Marcus and Law, Yuen and Davidescu, Arjana and Savii, George G. and Gatzweiler, Karl-Heinz and Staat, Manfred and Kuhlen, Torsten W.},
  title     = {Preliminary bone sawing model for a virtual reality-based training simulator of bilateral sagittal split osteotomy},
  series = {Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789)},
  booktitle = {Biomedical simulation : 6th International Symposium, ISBMS 2014, Strasbourg, France, October 16-17, 2014 : proceedings (Lecture notes in computer science : vol. 8789)},
  publisher = {Springer},
  address   = {Cham},
  isbn      = {978-3-319-12057-7 (Online)},
  doi       = {10.1007/978-3-319-12057-7_1},
  pages     = {1 -- 10},
  year      = {2014},
  abstract  = {Successful bone sawing requires a high level of skill and experience, which could be gained by the use of Virtual Reality-based simulators. A key aspect of these medical simulators is realistic force feedback. The aim of this paper is to model the bone sawing process in order to develop a valid training simulator for the bilateral sagittal split osteotomy, the most often applied corrective surgery in case of a malposition of the mandible. Bone samples from a human cadaveric mandible were tested using a designed experimental system. Image processing and statistical analysis were used for the selection of four models for the bone sawing process. The results revealed a polynomial dependency between the material removal rate and the applied force. Differences between the three segments of the osteotomy line and between the cortical and cancellous bone were highlighted.},
  language  = {en}
}
@article{AlhwarinFerreinScholl2014,
  author    = {Alhwarin, Faraj and Ferrein, Alexander and Scholl, Ingrid},
  title     = {IR stereo kinect: improving depth images by combining structured light with IR stereo},
  pages     = {1 -- 9},
  year      = {2014},
  language  = {en}
}
@article{DachwaldMikuckiTulaczyketal.2014,
  author    = {Dachwald, Bernd and Mikucki, Jill and Tulaczyk, Slawek and Digel, Ilya and Espe, Clemens and Feldmann, Marco and Francke, Gero and Kowalski, Julia and Xu, Changsheng},
  title     = {IceMole : A maneuverable probe for clean in situ analysis and sampling of subsurface ice and subglacial aquatic ecosystems},
  series = {Annals of Glaciology},
  volume    = {55},
  journal   = {Annals of Glaciology},
  number    = {65},
  publisher = {Cambridge University Press},
  address   = {Cambridge},
  issn      = {1727-5644},
  doi       = {10.3189/2014AoG65A004},
  pages     = {14 -- 22},
  year      = {2014},
  abstract  = {There is significant interest in sampling subglacial environments for geobiological studies, but they are difficult to access. Existing ice-drilling technologies make it cumbersome to maintain microbiologically clean access for sample acquisition and environmental stewardship of potentially fragile subglacial aquatic ecosystems. The IceMole is a maneuverable subsurface ice probe for clean in situ analysis and sampling of glacial ice and subglacial materials. The design is based on the novel concept of combining melting and mechanical propulsion. It can change melting direction by differential heating of the melting head and optional side-wall heaters. The first two prototypes were successfully tested between 2010 and 2012 on glaciers in Switzerland and Iceland. They demonstrated downward, horizontal and upward melting, as well as curve driving and dirt layer penetration. A more advanced probe is currently under development as part of the Enceladus Explorer (EnEx) project. It offers systems for obstacle avoidance, target detection, and navigation in ice. For the EnEx-IceMole, we will pay particular attention to clean protocols for the sampling of subglacial materials for biogeochemical analysis. We plan to use this probe for clean access into a unique subglacial aquatic environment at Blood Falls, Antarctica, with return of a subglacial brine sample.},
  language  = {en}
}
@incollection{MacdonaldMcGrathAppourchauxetal.2014,
  author    = {Macdonald, Malcolm and McGrath, C. and Appourchaux, T. and Dachwald, Bernd and Finsterle, W. and Gizon, L. and Liewer, P. C. and McInnes, Colin R. and Mengali, G. and Seboldt, Wolfgang and Sekii, T. and Solanki, S. K. and Velli, M. and Wimmer-Schweingruber, R. F. and Spietz, Peter and Reinhard, Ruedeger},
  title     = {Gossamer roadmap technology reference study for a solar polar mission},
  series = {Advances in solar sailing},
  booktitle = {Advances in solar sailing},
  editor    = {Macdonald, Malcolm},
  publisher = {Springer},
  address   = {Berlin, Heidelberg},
  isbn      = {978-3-642-34906-5},
  doi       = {10.1007/978-3-642-34907-2_17},
  pages     = {243 -- 257},
  year      = {2014},
  abstract  = {A technology reference study for a solar polar mission is presented. The study uses novel analytical methods to quantify the mission design space including the required sail performance to achieve a given solar polar observation angle within a given timeframe and thus to derive mass allocations for the remaining spacecraft sub-systems, that is excluding the solar sail sub-system. A parametric, bottom-up, system mass budget analysis is then used to establish the required sail technology to deliver a range of science payloads, and to establish where such payloads can be delivered to within a given timeframe. It is found that a solar polar mission requires a solar sail of side-length 100-125 m to deliver a 'sufficient value' minimum science payload, and that a 2.5 μm sail film substrate is typically required, however the design is much less sensitive to the boom specific mass.},
  language  = {en}
}
@misc{WollnyAlKaidyTippkoetteretal.2014,
  author    = {Wollny, S. and Al-Kaidy, H. and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Prozessintegrierte Magnetseparation im Labormaßstab mittels High-Gradient Magnetic Separator (HGMS)},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450618},
  pages     = {1507},
  year      = {2014},
  abstract  = {Die Hochgradient-Magnetseparation (HGMS) stellt eine Alternative zu konventionellen Methoden der Proteinaufarbeitung wie Filtration und Chromatographie dar und dient zudem als Prozessintensivierung. Bisherige Separatoren sind f{\"u}r Anwendungen von mehreren Litern Prozessvolumina Fermentationsmedium und Gramm Magnetpartikel ausgelegt. Bei der Entwicklung und Anwendung neuartiger Magnetpartikeloberfl{\"a}chen ist die Verf{\"u}gbarkeit großer Mengen nicht gegeben. Bisherige Filterkammern erh{\"o}hen zudem den Arbeitsaufwand und verursachen gr{\"o}ßere Partikelverluste bei Sp{\"u}lvorg{\"a}ngen oder der Reinigung aufgrund der Partikeladsorption. F{\"u}r Anwendungen im Maßstab < 500 mL wird deshalb ein Miniatur-Hochgradientfilter (miniHGF) entwickelt. Das Modell wird im 3D-Drucker Makerbot Replicator 2 gefertigt und magne-isierbare Dr{\"a}hte zur Partikelabscheidung eingesetzt. Die Vergleichbarkeit mit einem etablierten Magnetseparator wird anhand der Aufnahme von Durchbruchskurven und Bestimmung der Filtereffizienz untersucht. Die Praxistauglichkeit mit kleinen Volumina wird in wiederholten Batch-Versuchen mit auf Magnetpartikeln immobilisiertem Enzym und einem kolorimetrischen Assay gepr{\"u}ft.},
  language  = {de}
}
@inproceedings{TranStaatStavroulakis2014,
  author    = {Tran, Ngoc Trinh and Staat, Manfred and Stavroulakis, G. E.},
  title     = {A multicriteria method for truss optimization},
  series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  editor    = {Onate, E.},
  organization    = {World Congress on Computational Mechanics <11, 2014, Barcelona>},
  pages     = {1 -- 12},
  year      = {2014},
  language  = {en}
}
@article{LeandroBungCarvalho2014,
  author    = {Leandro, J. and Bung, Daniel Bernhard and Carvalho, R.},
  title     = {Measuring void fraction and velocity fields of a stepped spillway for skimming flow using non-intrusive methods},
  series = {Experiments in fluids},
  journal   = {Experiments in fluids},
  number    = {55},
  publisher = {Springer Nature},
  address   = {Heidelberg},
  issn      = {0723-4864 (Print) ; 1432-1114 (Online)},
  doi       = {10.1007/s00348-014-1732-6},
  pages     = {Art. 1732},
  year      = {2014},
  language  = {en}
}
@inproceedings{FrotscherKochRaatschenetal.2014,
  author    = {Frotscher, Ralf and Koch, Jan-Peter and Raatschen, Hans-J{\"u}rgen and Staat, Manfred},
  title     = {Evaluation of a computational model for drug action on cardiac tissue},
  series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona},
  booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20 - 25, 2014, Barcelona},
  editor    = {Onate, E.},
  organization    = {World Congress on Computational Mechanics <11, 2014, Barcelona>},
  pages     = {1 -- 12},
  year      = {2014},
  language  = {en}
}
@misc{TippkoetterWulfhorstMogueetal.2014,
  author    = {Tippk{\"o}tter, Nils and Wulfhorst, H. and Mogue, N. and M{\"o}hring, S. and Roth, J. and Ulber, Roland},
  title     = {Spektrometrische Messung und Modellierung der enzymatischen Hydrolyse von Biomasse nach Organosolv- und Liquid Hot Water-Aufschl{\"u}ssen (LHW)},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450269},
  pages     = {1584},
  year      = {2014},
  abstract  = {In diesem Beitrag wird die NIR- und MIR-Spektrometrie in Kombination mit multivariaten Kalibrationsmodellen zur Analyse von Monosacchariden und Cellulose aus Biomasse etabliert. Spektrengemischter Standardl{\"o}sungen mit definierten Glucose- und Xylosekonzentrationen in Wasser werden im NIR-(Lambda 750, Perkin Elmer, USA) und MIR-Bereich (Spektrum 100, PerkinElmer) in Gegenwart von entweder Carboxymethylcellulose oder Grasfasern aufgenommen. Darauf basierend werden Kalibrationsmodelle (Unscrambler®, CAMO-Software AS, Norwegen) entwickelt und zur Vorhersage der Zuckerkonzentration in den Hydrolyseproben und der Celluloseanteile angewendet. Dar{\"u}ber hinaus wird die Partikelgr{\"o}ße der Rohstoffe bestimmt. Die Messergebnisse bilden die experimentelle Basis f{\"u}r die numerische Modellierung der Reaktionskinetik der enzymatischen Hydrolyse von Lignocellulose. Das Modell kombiniert die Bilanzierung der Partikelgr{\"o}ßenverteilungen mit der Multienzymkinetik. Dabei werden neben der Partikelgr{\"o}ßenverteilung und der Substratkonzentration die Zusammensetzung der Rohstoffe nach Vorbehandlung sowie die Produktinhibierung und mehrere enzymatische Aktivit{\"a}ten ber{\"u}cksichtigt. Das Modell erm{\"o}glicht es, die Partikelgr{\"o}ßenverteilungen und die Konzentrationen der Substrate und Produkte w{\"a}hrend der Hydrolyse vorherzusagen und die kinetischen Parameter im Batch- sowie im Fed-Batch-Reaktor zu bestimmen.},
  language  = {de}
}
@book{Laack2014,
  author    = {Laack, Walter van},
  title     = {Schnittstelle Tod: Was spricht f{\"u}r unser Weiterleben?},
  publisher = {van Laack},
  address   = {Aachen},
  isbn      = {978-3-936624-19-9},
  pages     = {100 S.},
  year      = {2014},
  language  = {de}
}
@inproceedings{BhattaraiFrotscherSoraetal.2014,
  author    = {Bhattarai, Aroj and Frotscher, Ralf and Sora, M.-C. and Staat, Manfred},
  title     = {A 3D finite element model of the female pelvic floor for the reconstruction of urinary incontinence},
  series = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  booktitle = {11th World Congress on Computational Mechanics (WCCM XI) ; 5th European Conference on Computational Mechanics (ECCM V) ; 6th European Conference on Computational Fluid Dynamics (ECFD VI) ; July 20-25, 2014, Barcelona},
  editor    = {Onate, E.},
  organization    = {World Congress on Computational Mechanics <11, 2014, Barcelona>},
  pages     = {1 -- 12},
  year      = {2014},
  language  = {en}
}
@article{KueppersSteffenHellmuthetal.2014,
  author    = {K{\"u}ppers, Tobias and Steffen, Victoria and Hellmuth, Hendrik and O'Connell, Timothy and Bongaerts, Johannes and Maurer, Karl-Heinz and Wiechert, Wolfgang},
  title     = {Developing a new production host from a blueprint: Bacillus pumilus as an industrial enzyme producer},
  series = {Microbial cell factories},
  volume    = {13},
  journal   = {Microbial cell factories},
  publisher = {BioMed Central},
  address   = {London},
  issn      = {1475-2859 (E-Journal)},
  doi       = {10.1186/1475-2859-13-46},
  pages     = {Article No. 46},
  year      = {2014},
  language  = {en}
}
@article{PhamStaat2014,
  author    = {Pham, Phu Tinh and Staat, Manfred},
  title     = {FEM-based shakedown analysis of hardening structures},
  series = {Asia Pacific journal on computational engineering},
  journal   = {Asia Pacific journal on computational engineering},
  number    = {1},
  publisher = {SpringerOpen},
  address   = {Berlin},
  issn      = {2196-1166 (E-Journal)},
  doi       = {10.1186/2196-1166-1-4},
  pages     = {Article No. 4},
  year      = {2014},
  abstract  = {This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature.},
  language  = {en}
}
@article{HaagZontarSchleupenetal.2014,
  author    = {Haag, S. and Zontar, D. and Schleupen, Josef and M{\"u}ller, T. and Brecher, C.},
  title     = {Chain of refined perception in self-optimizing assembly of micro-optical systems},
  series = {Journal of sensors and sensor systems},
  volume    = {3},
  journal   = {Journal of sensors and sensor systems},
  number    = {1},
  publisher = {Copernicus Publ.},
  address   = {G{\"o}ttingen},
  issn      = {2194-878X},
  doi       = {10.5194/jsss-3-87-2014},
  pages     = {87 -- 95},
  year      = {2014},
  abstract  = {Today, the assembly of laser systems requires a large share of manual operations due to its complexity regarding the optimal alignment of optics. Although the feasibility of automated alignment of laser optics has been shown in research labs, the development effort for the automation of assembly does not meet economic requirements - especially for low-volume laser production. This paper presents a model-based and sensor-integrated assembly execution approach for flexible assembly cells consisting of a macro-positioner covering a large workspace and a compact micromanipulator with camera attached to the positioner. In order to make full use of available models from computer-aided design (CAD) and optical simulation, sensor systems at different levels of accuracy are used for matching perceived information with model data. This approach is named "chain of refined perception", and it allows for automated planning of complex assembly tasks along all major phases of assembly such as collision-free path planning, part feeding, and active and passive alignment. The focus of the paper is put on the in-process image-based metrology and information extraction used for identifying and calibrating local coordinate systems as well as the exploitation of that information for a part feeding process for micro-optics. Results will be presented regarding the processes of automated calibration of the robot camera as well as the local coordinate systems of part feeding area and robot base.},
  language  = {en}
}
@inproceedings{HecklWeilerFleischhakeretal.2014,
  author    = {Heckl, O. H. and Weiler, Sascha and Fleischhaker, Robert and Gebs, Raphael and Budnicki, Aleksander and Wolf, M. and Kleinbauer, Jochen and Russ, S. and Kumkar, M. and Sutter, Dirk H.},
  title     = {Industry-grade high average power femtosecond light source},
  series = {Frontiers in ultrafast optics: Biomedical, scientific, and industrial applications XIV : 1 Februar 2014, San Francisco, USA. - (SPIE proceedings series ; 8972)},
  booktitle = {Frontiers in ultrafast optics: Biomedical, scientific, and industrial applications XIV : 1 Februar 2014, San Francisco, USA. - (SPIE proceedings series ; 8972)},
  editor    = {Heisterkamp, Alexander and Herman, Peter R. and Meunier, Michael and Nolte, Stefan},
  publisher = {SPIE, International Society for Optical Engineering},
  doi       = {10.1117/12.2039337},
  pages     = {89720P -- 89720P-7},
  year      = {2014},
  language  = {en}
}
@misc{Jacobs2014,
  author    = {Jacobs, Stephan},
  title     = {Es gibt keine nichtfunktionalen Tests. Es gibt nur nichtfunktionale Anforderungen!},
  pages     = {27 Folien},
  year      = {2014},
  language  = {de}
}
@article{ScheerMclaughlinRodeetal.2014,
  author    = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.},
  title     = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057885},
  pages     = {1022 -- 1030},
  year      = {2014},
  abstract  = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.},
  language  = {en}
}
@article{LuisierLempiaeinenScherbichleretal.2014,
  author    = {Luisier, Rapha{\"e}lle and Lempi{\"a}inen, Harri and Scherbichler, Nina and Braeuning, Albert and Geissler, Miriam and Dubost, Valerie and M{\"u}ller, Arne and Scheer, Nico and Chibout, Salah-Dine and Hara, Hisanori and Picard, Frank and Theil, Diethilde and Couttet, Philippe and Vitobello, Antonio and Grenet, Olivier and Grasl-Kraupp, Bettina and Ellinger-Ziegelbauer, Heidrung and Thomson, John P. and Meehan, Richard R. and Elcombe, Clifford R. and Henderson, Colin J. and Wolf, C. Roland and Schwarz, Michael and Moulin, Pierre and Terranova, Remi and Moggs, Jonathan G.},
  title     = {Phenobarbital Induces Cell Cycle Transcriptional Responses in Mouse Liver Humanized for Constitutive Androstane and Pregnane X Receptors},
  series = {Toxicological Sciences},
  volume    = {139},
  journal   = {Toxicological Sciences},
  number    = {2},
  publisher = {Oxford University Press},
  address   = {Oxford},
  issn      = {1094-2025},
  doi       = {https://doi.org/10.1093/toxsci/kfu038},
  pages     = {501 -- 511},
  year      = {2014},
  abstract  = {The constitutive androstane receptor (CAR) and the pregnane X receptor (PXR) are closely related nuclear receptors involved in drug metabolism and play important roles in the mechanism of phenobarbital (PB)-induced rodent nongenotoxic hepatocarcinogenesis. Here, we have used a humanized CAR/PXR mouse model to examine potential species differences in receptor-dependent mechanisms underlying liver tissue molecular responses to PB. Early and late transcriptomic responses to sustained PB exposure were investigated in liver tissue from double knock-out CAR and PXR (CARᴷᴼ-PXRᴷᴼ), double humanized CAR and PXR (CARʰ-PXRʰ), and wild-type C57BL/6 mice. Wild-type and CARʰ-PXRʰ mouse livers exhibited temporally and quantitatively similar transcriptional responses during 91 days of PB exposure including the sustained induction of the xenobiotic response gene Cyp2b10, the Wnt signaling inhibitor Wisp1, and noncoding RNA biomarkers from the Dlk1-Dio3 locus. Transient induction of DNA replication (Hells, Mcm6, and Esco2) and mitotic genes (Ccnb2, Cdc20, and Cdk1) and the proliferation-related nuclear antigen Mki67 were observed with peak expression occurring between 1 and 7 days PB exposure. All these transcriptional responses were absent in CARᴷᴼ-PXRᴷᴼ mouse livers and largely reversible in wild-type and CARʰ-PXRʰ mouse livers following 91 days of PB exposure and a subsequent 4-week recovery period. Furthermore, PB-mediated upregulation of the noncoding RNA Meg3, which has recently been associated with cellular pluripotency, exhibited a similar dose response and perivenous hepatocyte-specific localization in both wild-type and CARʰ-PXRʰ mice. Thus, mouse livers coexpressing human CAR and PXR support both the xenobiotic metabolizing and the proliferative transcriptional responses following exposure to PB.},
  language  = {en}
}
@article{SalpatiChuChenetal.2014,
  author    = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja},
  title     = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {8},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057976},
  pages     = {1301 -- 1313},
  year      = {2014},
  abstract  = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.},
  language  = {en}
}
@article{ScheerWolf2014,
  author    = {Scheer, Nico and Wolf, C. Roland},
  title     = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications},
  series = {Xenobiotica},
  volume    = {44},
  journal   = {Xenobiotica},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1366-5928},
  doi       = {10.3109/00498254.2013.815831},
  pages     = {96 -- 108},
  year      = {2014},
  abstract  = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.},
  language  = {en}
}
@book{SchulteZurhausen2014,
  author    = {Schulte-Zurhausen, Manfred},
  title     = {Organisation},
  edition   = {6., {\"u}berarb. und aktualisierte Aufl.},
  publisher = {Vahlen},
  address   = {M{\"u}nchen},
  isbn      = {978-3-8006-4689-0},
  pages     = {XVI, 687 S. : graph. Darst.},
  year      = {2014},
  language  = {de}
}
@inproceedings{SchirraBauschatWatmuff2014,
  author    = {Schirra, Julian and Bauschat, J.-Michael and Watmuff, J.H.},
  title     = {Accurate induced drag prediction for highly non-planar lifting systems},
  series = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia},
  booktitle = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia},
  pages     = {4 Seiten},
  year      = {2014},
  abstract  = {The impact of wake model effects is investigated for two highly non-planar lifting systems. Dependent on the geometrical arrangement of the configuration, the wake model shape is found to considerably affect the estimation. Particularly at higher angles of attack, an accurate estimation based on the common linear wake model approaches is involved.},
  language  = {en}
}
@article{JoerissenHeger2014,
  author    = {J{\"o}rissen, J{\"o}rg and Heger, Michael},
  title     = {Zur Wirkung hochschuldidaktisch fundierter und in den Fachbereichen verankerter Lehrveranstaltungsevaluation},
  series = {Qualit{\"a}t in der Wissenschaft (QiW)},
  volume    = {8},
  journal   = {Qualit{\"a}t in der Wissenschaft (QiW)},
  number    = {2+3},
  publisher = {Universit{\"a}tsverlag Webler},
  address   = {Bielefeld},
  issn      = {1860-3041},
  pages     = {70 -- 80},
  year      = {2014},
  language  = {de}
}
@article{HoehrPaulssenBenardetal.2014,
  author    = {Hoehr, Cornelia and Paulßen, Elisabeth and Benard, Francois and Lee, Chris Jaeil and Hou, Xinchi and Badesso, Brian and Ferguson, Simon and Miao, Qing and Yang, Hua and Buckley, Ken and Hanemaayer, Victoire and Zeisler, Stefan and Ruth, Thomas and Celler, Anna and Schaffer, Paul},
  title     = {⁴⁴ᶢSc production using a water target on a 13 MeV cyclotron},
  series = {Nuclear medicine and biology},
  volume    = {41},
  journal   = {Nuclear medicine and biology},
  number    = {5},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-9614},
  doi       = {10.1016/j.nucmedbio.2013.12.016},
  pages     = {401 -- 406},
  year      = {2014},
  abstract  = {Access to promising radiometals as isotopes for novel molecular imaging agents requires that they are routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an isotope generator for the metal of interest is necessary, both of which can introduce significant hurdles in development of less common isotopes. Herein, we describe the production of ⁴⁴Sc (t₁⸝₂ = 3.97 h, Eavg,β⁺ = 1.47 MeV, branching ratio = 94.27\%) in a solution target and an automated loading system which allows a quick turn-around between different radiometallic isotopes and therefore greatly improves their availability for tracer development. Experimental yields are compared to theoretical calculations.},
  language  = {en}
}
@article{Wilke2014,
  author    = {Wilke, Thomas},
  title     = {Gebaute Geschichte in Turin},
  series = {Kunsttexte.de},
  volume    = {2014},
  journal   = {Kunsttexte.de},
  number    = {1},
  publisher = {Humboldt-Universit{\"a}t zu Berlin},
  address   = {Berlin},
  issn      = {1618-8101},
  doi       = {10.18452/7197},
  pages     = {13 Seiten},
  year      = {2014},
  abstract  = {St{\"a}dte sind Stein gewordene Geschichte. Ihre realisierte Form erm{\"o}glicht Geschichte zu erleben und die Stadtentwicklung nachzuvollziehen. Besonders in Turin ist ablesbar, wie das Haus Savoyen den Ausbau der neuen Hauptstadt zu einer der f{\"u}hrenden Barockmetropolen Europas beeinflusste.},
  language  = {de}
}
@article{KrollLudwigsKaesling2014,
  author    = {Kroll-Ludwigs, Kathrin and Kaesling, Katharina},
  title     = {Family Law and Culture in Europe: Developments, Challenges and Opportunities - Konferenz der Commission on European Family Law vom 29.-31. August 2013, Bonn},
  series = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)},
  journal   = {Zeitschrift f{\"u}r Europ{\"a}isches Privatrecht (ZEuP)},
  number    = {3},
  publisher = {Beck},
  address   = {M{\"u}nchen},
  issn      = {0943-3929},
  pages     = {673 -- 676},
  year      = {2014},
  abstract  = {Vor dem Hintergrund zunehmender gesellschaftlicher Ver{\"a}nderungen bei den Lebens- und Familienformen hat es sich die Commission on European Family Law (CEFL) seit 2001 zum Ziel gesetzt, unverbindliche Regelungsvorschl{\"a}ge f{\"u}r ein europaweit einheitliches Familienrecht zu schaffen. Die Vorstellung und Diskussion dieser auf rechtsvergleichender Basis erstellten Principles erfolgt auf den regelm{\"a}ßig veranstalteten Tagungen der CEFL. Die nunmehr f{\"u}nfte Konferenz zum Thema „Family Law and Culture in Europe - Developments, Challenges and Opportunities" fand erstmals in Deutschland statt. Ausgerichtet wurde die Veranstaltung, zu der ca. 200 Teilnehmerinnen und Teilnehmern aus Wissenschaft und Praxis aus insgesamt 33 L{\"a}ndern angereist waren, von Nina Dethloff (Direktorin des Instituts f{\"u}r Deutsches, Europ{\"a}isches und Internationales Familienrecht an der Universit{\"a}t Bonn), Katharina Boele-Woelki (Direktorin des Utrecht Centre for European Research into Family Law und Preistr{\"a}gerin des Anneliese Maier-Forschungspreises der Alexander von Humboldt-Stiftung) und Werner Gephart (Direktor des K{\"a}te Hamburger Kollegs „Recht als Kultur").},
  language  = {de}
}
@article{Bernecker2014,
  author    = {Bernecker, Andreas},
  title     = {Do politicians shirk when reelection is certain? Evidence from the German parliament},
  series = {European Journal of Political Economy},
  volume    = {36},
  journal   = {European Journal of Political Economy},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {0176-2680},
  doi       = {10.1016/j.ejpoleco.2014.07.001},
  pages     = {55 -- 70},
  year      = {2014},
  abstract  = {Does stiffer electoral competition reduce political shirking? For a micro-analysis of this question, I construct a new data set spanning the years 2005 to 2012 covering biographical and political information about German Members of Parliament (MPs), including their attendance rates in voting sessions. For the parliament elected in 2009, I show that indeed opposition party MPs who expect to face a close race in their district show significantly and relevantly lower absence rates in parliament beforehand. MPs of governing parties seem not to react significantly to electoral competition. These results are confirmed by an analysis of the parliament elected in 2005, by several robustness checks, and also by employing an instrumental variable strategy exploiting convenient peculiarities of the German electoral system. The study also shows how MPs elected via party lists react to different levels of electoral competition.},
  language  = {en}
}
@article{Bernecker2014,
  author    = {Bernecker, Andreas},
  title     = {Divided Government and the Adoption of Economic Reforms},
  series = {CESifo DICE Report - Journal for Institutional Comparison},
  volume    = {12},
  journal   = {CESifo DICE Report - Journal for Institutional Comparison},
  number    = {4},
  publisher = {Ifo Institute for Economic Research},
  address   = {M{\"u}nchen},
  issn      = {1612-0663},
  pages     = {47 -- 52},
  year      = {2014},
  language  = {en}
}
@book{Bernecker2014,
  author    = {Bernecker, Andreas},
  title     = {Essays in Empirical Political Economics},
  pages     = {XI, 174 S. : Ill., graph. Darst.},
  year      = {2014},
  language  = {en}
}
@incollection{KrollLudwigs2014,
  author    = {Kroll-Ludwigs, Kathrin},
  title     = {Vorbemerkung vor \S 1353},
  series = {Erman, B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug) , ErbbauRG, LPartG, ProdHaftG, VBVG, VersAus-glG und WEG},
  booktitle = {Erman, B{\"u}rgerliches Gesetzbuch : Handkommentar mit AGG, EGBGB (Auszug) , ErbbauRG, LPartG, ProdHaftG, VBVG, VersAus-glG und WEG},
  editor    = {Ermann, Walter, and Grunewald, Barbara and Maier-Reimer, Georg},
  publisher = {Verlag Dr. Otto Schmidt},
  address   = {K{\"o}ln},
  isbn      = {978-3-50447-102-6},
  year      = {2014},
  language  = {de}
}