@article{KurbelPietsch1987, author = {Kurbel, K. and Pietsch, Wolfram}, title = {Projektmanagement bei Expertensystem-Entwicklungen}, series = {Arbeitsberichte des Lehrstuhls f{\"u}r Betriebsinformatik / Lehrstuhl f{\"u}r Betriebsinformatik, Fachbereich Wirtschafts- und Sozialwissenschaften, Universit{\"a}t Dortmund}, journal = {Arbeitsberichte des Lehrstuhls f{\"u}r Betriebsinformatik / Lehrstuhl f{\"u}r Betriebsinformatik, Fachbereich Wirtschafts- und Sozialwissenschaften, Universit{\"a}t Dortmund}, number = {H. November}, pages = {1 -- 21}, year = {1987}, language = {de} } @article{MartinGonzalezKotliarRiosMartinezetal.2014, author = {Martin-Gonzalez, Anabel and Kotliar, Konstantin and Rios-Martinez, Jorge and Lanzl, Ines and Navab, Nassir}, title = {Mediated-reality magnification for macular degeneration rehabilitation}, series = {Journal of Modern Optics}, volume = {61}, journal = {Journal of Modern Optics}, number = {17}, publisher = {Taylor \& Francis}, address = {London}, issn = {1362-3044}, doi = {10.1080/09500340.2014.936110}, pages = {1400 -- 1408}, year = {2014}, language = {en} } @article{FissabreHertwigSchmidtetal.2002, author = {Fissabre, Anke and Hertwig, Christine and Schmidt, Klaus and Sonnleitner, Andrea}, title = {Ortrand : Das Lehnsm{\"u}hlschloss : Ein Herrenhaus des 16. Jahrhunderts}, series = {Brandenburgische Denkmalpflege}, journal = {Brandenburgische Denkmalpflege}, number = {2}, issn = {0942-3397}, pages = {29 -- 42}, year = {2002}, language = {de} } @article{Wollert2009, author = {Wollert, J{\"o}rg}, title = {Funk-Suche : Lokalisierung und Ortsbestimmungs-Verfahren f{\"u}r mobile Systeme}, series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme}, journal = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme}, number = {H. 2}, publisher = {Weka Fachmedien GmbH}, address = {Haar}, pages = {24 -- 27}, year = {2009}, language = {de} } @article{Pietsch1987, author = {Pietsch, Wolfram}, title = {Qualit{\"a}t in die Wiege gelegt}, series = {Markt \& Technik : die unabh{\"a}ngige Wochenzeitung f{\"u}r Elektronik}, journal = {Markt \& Technik : die unabh{\"a}ngige Wochenzeitung f{\"u}r Elektronik}, number = {H. 10}, issn = {0344-8843}, pages = {58 -- 63}, year = {1987}, language = {de} } @article{Wollert2007, author = {Wollert, J{\"o}rg}, title = {Wireless in industriellen Anwendungen}, series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Scout : Leitfaden f{\"u}r Elektronik-Entwickler}, journal = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Scout : Leitfaden f{\"u}r Elektronik-Entwickler}, issn = {1863-3420}, pages = {40 -- 46}, year = {2007}, language = {de} } @article{Timme2015, author = {Timme, Michael}, title = {K{\"u}ndigung - Die Vorhersehbarkeit eines zuk{\"u}nftigen Eigenbedarfs f{\"u}r den Vermieter}, series = {Monatsschrift f{\"u}r Deutsches Recht : MDR : Zeitschrift f{\"u}r die Zivilrechts-Praxis}, volume = {69}, journal = {Monatsschrift f{\"u}r Deutsches Recht : MDR : Zeitschrift f{\"u}r die Zivilrechts-Praxis}, number = {9}, publisher = {Verlag Dr. Otto Schmidt}, address = {K{\"o}ln}, issn = {0340-1812}, pages = {489 -- 490}, year = {2015}, language = {de} } @article{Fissabre2015, author = {Fissabre, Anke}, title = {Konstruktion und Raumform im Kirchenbau der Moderne : Die L{\"a}ngsbinderkirchen von Hans Herkommer}, series = {In situ : Zeitschrift f{\"u}r Architekturgeschichte}, volume = {7}, journal = {In situ : Zeitschrift f{\"u}r Architekturgeschichte}, number = {1}, publisher = {Wernersche Verlagsgesellschaft}, address = {Worms}, issn = {1866-959X}, pages = {117 -- 124}, year = {2015}, language = {de} } @article{Fissabre2013, author = {Fissabre, Anke}, title = {Residenzarchitektur des Kurf{\"u}rstenpaares August und Anna von Sachsen als Ausdruck musterhafter Landeskultivierung - Das Renaissanceschloss Lichtenburg}, series = {Mitteilungen der Residenzen-Kommission der Akademie der Wissenschaften zu G{\"o}ttingen, Neue Folge, Stadt und Hof}, volume = {2}, journal = {Mitteilungen der Residenzen-Kommission der Akademie der Wissenschaften zu G{\"o}ttingen, Neue Folge, Stadt und Hof}, issn = {0941-0937}, pages = {40 -- 59}, year = {2013}, language = {de} } @article{KotliarDrozdovaShamshinova2006, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment.
 Part I. Ocular blood circulation and its quantitative estimation}, series = {National journal Glaucoma}, volume = {Vol. 5}, journal = {National journal Glaucoma}, number = {No. 3}, issn = {2078-4104}, pages = {62 -- 73}, year = {2006}, language = {ru} } @article{KotliarLanzl2002, author = {Kotliar, Konstantin and Lanzl, I. M.}, title = {Biomechanical modeling of the aqueous humor outflow after non-penetrating glaucoma filtration surgery in the human eye}, series = {Acta of bioengineering and biomechanics}, volume = {Vol. 4}, journal = {Acta of bioengineering and biomechanics}, number = {Suppl. 1}, issn = {1509-409X}, pages = {728 -- 729}, year = {2002}, language = {de} } @article{BarthWollert1998, author = {Barth, Heiko and Wollert, J{\"o}rg}, title = {SMARTes Konzept - von Produkt zur Fabrik}, series = {Facility-Management : Integration, Planung, Geb{\"a}udemanagement}, volume = {Bd. 4}, journal = {Facility-Management : Integration, Planung, Geb{\"a}udemanagement}, number = {H. August}, issn = {0948-0048}, pages = {30 -- 35}, year = {1998}, language = {de} } @article{SchneiderSchneiderMeinhardtetal.2015, author = {Schneider, Wilhelm and Schneider, Bettina and Meinhardt, Kerstin and Kinder, Stephanie}, title = {Die Fallstudie : Aufstellung eines Anlagespiegels}, series = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Examen, Berufseinstieg und Fortbildung}, volume = {44}, journal = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Examen, Berufseinstieg und Fortbildung}, number = {5}, publisher = {Lange}, address = {D{\"u}sseldorf}, issn = {0340-3084}, year = {2015}, language = {de} } @article{BorchertHasenbeckJungbluthetal.2009, author = {Borchert, J{\"o}rg and Hasenbeck, Marc and Jungbluth, Christian and Schemm, Ralf}, title = {Bewertung und Steuerung von Gasspeichern bzw. Gasspeicherscheiben}, series = {Zeitschrift f{\"u}r Energiewirtschaft}, volume = {33}, journal = {Zeitschrift f{\"u}r Energiewirtschaft}, number = {4}, publisher = {Springer}, address = {Berlin}, issn = {1866-2765}, doi = {10.1007/s12398-009-0033-x}, pages = {279 -- 293}, year = {2009}, abstract = {In diesem Artikel werden zun{\"a}chst einleitend der Gasmarkt Deutschland und der sich daraus ergebende Speicherbedarf skizziert. Folgend wird auf verschiedene Speichernutzen aus betriebswirtschaftlicher Perspektive eingegangen und die in diesem Artikel vorgestellten Bewertungsverfahren einleitend beschrieben. In diesem Artikel werden stochastische Optimierungsmethoden aufgegriffen, die sowohl eine Bewertung der Speicher gegen{\"u}ber einem Spotpreis, als auch gegen{\"u}ber einer gesamten Forwardcurve erm{\"o}glichen. Hierzu werden zun{\"a}chst Modelle zur Beschreibung der Marktpreise vorgestellt und anhand empirischer Daten kalibriert. Dann wird eine beispielhafte Speicherscheibe zun{\"a}chst auf Basis der LeastSquareMonteCarloTechnik gegen{\"u}ber dem stochastischen mehrfaktoriellen Spotpreismodell bewertet. Hieran schließt sich die Vorstellung der Bewertung sowie des Hedgings gegen{\"u}ber der Forwardcurve an. Abschließend erfolgt eine vergleichende Gegen{\"u}berstellung beider Verfahren.}, language = {de} } @article{BorchertHasenbeck2009, author = {Borchert, J{\"o}rg and Hasenbeck, Marc}, title = {Bewertung und Steuerung von Kraftwerksscheiben}, series = {Zeitschrift f{\"u}r Energiewirtschaft}, volume = {33}, journal = {Zeitschrift f{\"u}r Energiewirtschaft}, number = {2}, publisher = {Vieweg}, address = {Wiesbaden}, issn = {1866-2765}, doi = {10.1007/s12398-009-0014-0}, pages = {115 -- 126}, year = {2009}, language = {de} } @article{BorchertSchemm2007, author = {Borchert, J{\"o}rg and Schemm, R.}, title = {Einsatz der Portfoliotheorie im Asset Allokations-Prozess am Beispiel eines fiktiven Anlageraumes von Windkraftstandorten}, series = {Zeitschrift f{\"u}r Energiewirtschaft}, volume = {31}, journal = {Zeitschrift f{\"u}r Energiewirtschaft}, number = {4}, issn = {0343-5377}, pages = {311}, year = {2007}, language = {de} } @article{JungbluthBorchert2008, author = {Jungbluth, Christian and Borchert, J{\"o}rg}, title = {M{\"o}glichkeiten der Strompreisbeeinflussung im oligopolistischen Markt}, series = {ZNER Zeitschrift f{\"u}r Neues Energierecht}, journal = {ZNER Zeitschrift f{\"u}r Neues Energierecht}, number = {4}, pages = {314 -- 323}, year = {2008}, language = {de} } @article{Borchert2003, author = {Borchert, J{\"o}rg}, title = {Von Beschaffern und Spekulanten}, series = {Energie \& Management}, journal = {Energie \& Management}, number = {3}, issn = {0945-8794}, pages = {16 -- 17}, year = {2003}, language = {de} } @article{WalterBorchert2002, author = {Walter, G. and Borchert, J{\"o}rg}, title = {Der Einsatz von Realoptionen in der Elektrizit{\"a}tswirtschaft}, series = {M \& A Review}, journal = {M \& A Review}, number = {4}, issn = {1616-0878}, pages = {198}, year = {2002}, language = {de} } @article{KotliarKharoubiSchmidtTrucksaessetal.2009, author = {Kotliar, Konstantin and Kharoubi, A. and Schmidt-Trucks{\"a}ß, A. and Halle, M. and Lanzl, I.}, title = {Does internal longitudinal microstructure of retinal veins change with age in medically healthy persons?}, series = {Acta Ophthalmologica}, volume = {Vol. 87}, journal = {Acta Ophthalmologica}, number = {Suppl. S244}, publisher = {Wiley}, address = {Weinheim}, issn = {1600-0420 (E-Journal); 1755-3768 (E-Journal); 0001-639X (Print); 1395-3907 (Print); 1755-375X (Print)}, pages = {0}, year = {2009}, language = {en} } @article{KappmeyerKotliarLanzl2009, author = {Kappmeyer, K. and Kotliar, Konstantin and Lanzl, I. M.}, title = {Spielen von Blasinstrumenten und Augeninnendruck}, series = {Zeitschrift f{\"u}r praktische Augenheilkunde \& augen{\"a}rztliche Fortbildung : ZPA}, volume = {Bd. 30}, journal = {Zeitschrift f{\"u}r praktische Augenheilkunde \& augen{\"a}rztliche Fortbildung : ZPA}, issn = {1436-0322}, pages = {169 -- 171}, year = {2009}, language = {de} } @article{KotliarDrozdovaShamshinova2007, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 2. Static and dynamic assessment of retinal vessel reaction to stimuli}, series = {National Journal Glaucoma}, volume = {Vol. 6}, journal = {National Journal Glaucoma}, number = {No. 2}, issn = {2078-4104}, pages = {64 -- 71}, year = {2007}, language = {ru} } @article{KotliarDrozdovaShamshinova2007, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part III. Non-invasive methods of assessment of ocular blood flow. 1. Assessment of blood cell velocities and flow rates in intraocular vessels and vascular beds}, series = {Journal of Glaucoma}, volume = {Vol. 6}, journal = {Journal of Glaucoma}, number = {1}, issn = {2078-4104}, pages = {61 -- 68}, year = {2007}, language = {ru} } @article{KotliarDrozdovaShamshinova2006, author = {Kotliar, Konstantin and Drozdova, G. A. and Shamshinova, A. M.}, title = {Ocular hemodinamics and contemporary methods of its assessment. Part II. Invasive methods of assessment of ocular blood flow}, series = {National Journal Glaucoma}, volume = {Vol. 5}, journal = {National Journal Glaucoma}, number = {No. 4}, issn = {2078-4104}, pages = {37 -- 49}, year = {2006}, language = {ru} } @article{Wollert1997, author = {Wollert, J{\"o}rg}, title = {Wieviel Echtzeit kann Windows?}, series = {IEE : elektrische Automatisierung und Antriebstechnik}, volume = {Jg. 42}, journal = {IEE : elektrische Automatisierung und Antriebstechnik}, number = {Nr. 9}, issn = {1434-2898}, pages = {30 -- 37}, year = {1997}, language = {de} } @article{Wollert1996, author = {Wollert, J{\"o}rg}, title = {Zeitgem{\"a}ß : Echtzeit-Zusatz f{\"u}r Windows 3.11 und Windows 95}, series = {ELRAD : Magazin f{\"u}r Elektronik und technische Rechneranwendungen}, journal = {ELRAD : Magazin f{\"u}r Elektronik und technische Rechneranwendungen}, number = {H. 9}, issn = {0170-1827}, pages = {96 -- 99}, year = {1996}, language = {de} } @article{Wollert2008, author = {Wollert, J{\"o}rg}, title = {Bluetooth in der Klemme}, series = {Computer \& Automation : Fachmedium der Automatisierungstechnik}, journal = {Computer \& Automation : Fachmedium der Automatisierungstechnik}, number = {H. 10}, issn = {1615-8512}, pages = {62 -- 67}, year = {2008}, language = {de} } @article{FissabreKleutersLohmann2013, author = {Fissabre, Anke and Kleuters, Elmar and Lohmann, Daniel}, title = {„Beweglicher und toleranter als jede alte Harmonie" : Das Haus der Jugend von Rudolf Schwarz und Hans Schwippert in Aachen}, series = {In situ : Zeitschrift f{\"u}r Architekturgeschichte}, volume = {5}, journal = {In situ : Zeitschrift f{\"u}r Architekturgeschichte}, number = {2}, publisher = {Werner}, address = {Worms}, issn = {1866-959X}, pages = {267 -- 274}, year = {2013}, language = {de} } @article{FissabreLohmann2012, author = {Fissabre, Anke and Lohmann, Daniel}, title = {Verlust einer „tragenden Wand" : Das Haus der Jugend von Rudolf Schwarz in Aachen}, series = {Bauwelt}, volume = {103}, journal = {Bauwelt}, number = {45}, publisher = {Bauverlag BV}, address = {G{\"u}tersloh}, issn = {0005-6855}, pages = {6 -- 7}, year = {2012}, language = {de} } @article{Fissabre2011, author = {Fissabre, Anke}, title = {Dachterrassen der Renaissance - „Cosa pi{\`u} maravigliosa che gl'orti pensili di Babbilonia"}, series = {Architectura : Zeitschrift f{\"u}r Geschichte der Baukunst}, volume = {41}, journal = {Architectura : Zeitschrift f{\"u}r Geschichte der Baukunst}, number = {1}, publisher = {De Gruyter}, address = {Berlin}, issn = {0044-863X}, pages = {27 -- 46}, year = {2011}, language = {de} } @article{Fissabre2005, author = {Fissabre, Anke}, title = {Das Fach Baugeschichte : Eine Umfrage an 18 deutschsprachigen Architekturfakult{\"a}ten}, series = {Bauwelt}, volume = {96}, journal = {Bauwelt}, number = {40-41}, issn = {0005-6855}, pages = {48 -- 57}, year = {2005}, language = {de} } @article{WarmerWagnerSchoeningetal.2015, author = {Warmer, Johannes and Wagner, Patrick and Sch{\"o}ning, Michael Josef and Kaul, Peter}, title = {Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431882}, pages = {1289 -- 1298}, year = {2015}, language = {en} } @article{DelleHuckBaeckeretal.2015, author = {Delle, Lotta E. and Huck, Christina and B{\"a}cker, Matthias and M{\"u}ller, Frank and Grandthyll, Samuel and Jacobs, Karin and Lilischkis, Rainer and Vu, Xuan T. and Sch{\"o}ning, Michael Josef and Wagner, Patrick and Thoelen, Roland and Weil, Maryam and Ingebrandt, Sven}, title = {Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431863}, pages = {1327 -- 1334}, year = {2015}, language = {en} } @article{Timme2015, author = {Timme, Michael}, title = {Versagung von Pkh trotz Zulassung der Revi­sion wegen grunds{\"a}tzlicher Bedeutung}, series = {Neue Juristische Wochenschrift (NJW)}, journal = {Neue Juristische Wochenschrift (NJW)}, number = {30}, publisher = {Beck}, address = {M{\"u}nchen}, issn = {0341-1915}, pages = {2173 -- 2175}, year = {2015}, language = {de} } @article{SeiblerKleinriddersKueterLuksetal.2007, author = {Seibler, Jost and Kleinridders, Andre and K{\"u}ter-Luks, Birgit and Niehaves, Sandra and Br{\"u}ning, Jens C. and Schwenk, Frieder}, title = {Reversible gene knockdown in mice using a tight, inducible shRNA expression system}, series = {Nucleic Acids Research}, volume = {35}, journal = {Nucleic Acids Research}, number = {7}, issn = {1362-4962}, doi = {10.1093/nar/gkm122}, pages = {e54}, year = {2007}, language = {en} } @article{PlumMaHampeletal.2006, author = {Plum, Leona and Ma, Xiaosong and Hampel, Brigitte and Balthasar, Nina and Coppari, Roberto and M{\"u}nzberg, Heike and Shanabrough, Marya and Burdakov, Denis and Rother, Eva and Janoschek, Ruth and Alber, Jens and Belgardt, Bengt F. and Koch, Linda and Seibler, Jost and Schenk, Frieder and Fekete, Csaba and Suzuki, Akira and Mak, Tak W. and Krone, Wilhelm and Horvath, Tamas L. and Ashcroft, Frances M. and Br{\"u}ning, Jens C.}, title = {Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity}, series = {The Journal of Clinical Investigation (JCI)}, volume = {116}, journal = {The Journal of Clinical Investigation (JCI)}, number = {7}, issn = {1558-8238}, doi = {10.1172/JCI27123}, pages = {1886 -- 1901}, year = {2006}, language = {en} } @article{SeiblerKueterLuksKernetal.2005, author = {Seibler, Jost and K{\"u}ter-Luks, Birgit and Kern, Heidrun and Streu, Sandra and Plum, Leona and Maurer, Jan and K{\"u}hn, Ralf and Br{\"u}ning, Jens C. and Schwenk, Frieder}, title = {Single copy shRNA configuration for ubiquitous gene knockdown in mice}, series = {Nucleic Acids Research}, volume = {33}, journal = {Nucleic Acids Research}, number = {7}, issn = {1362-4962}, doi = {10.1093/nar/gni065}, pages = {e67}, year = {2005}, language = {en} } @article{SeiblerZevnikKueterLuksetal.2003, author = {Seibler, Jost and Zevnik, Branko and K{\"u}ter-Luks, Birgit and Andreas, Susanne and Kern, Heidrun and Hennek, Thomas and Rode, Anja and Heimann, Cornelia and Faust, Nicole and Kauselmann, Gunther and Schoor, Michael and Jaenisch, Rudolf and Rajewsky, Klaus and K{\"u}hn, Ralf and Schwenk, Frieder}, title = {Rapid generation of inducible mouse mutants}, series = {Nucleic Acids Research}, volume = {33}, journal = {Nucleic Acids Research}, number = {4}, issn = {1362-4962}, doi = {10.1093/nar/gng012}, pages = {e12}, year = {2003}, language = {en} } @article{GoetzeBaerWinkelmannetal.2005, author = {Goetze, Sandra and Baer, Alexandra and Winkelmann, Silke and Nehlsen, Kristina and Seibler, Jost and Maass, Karin and Bode, J{\"u}rgen}, title = {Performance of genomic bordering elements at predefined genomic loci}, series = {Molecular and Cellular Biology}, volume = {25}, journal = {Molecular and Cellular Biology}, number = {6}, issn = {1098-5549}, doi = {10.1128/MCB.25.6.2260-2272.2005}, pages = {2260 -- 2272}, year = {2005}, language = {en} } @article{YoshinobuMoritzFingeretal.2006, author = {Yoshinobu, Tatsuo and Moritz, Werner and Finger, Friedhelm and Sch{\"o}ning, Michael Josef}, title = {Application of thin-film amorphous silicon to chemical imaging}, series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, journal = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, number = {Paper 0910-A-20-01}, editor = {Comini, Elisabetta}, isbn = {9781558998711}, pages = {1 -- 10}, year = {2006}, language = {en} } @article{TakenagaSchneiderErbayetal.2015, author = {Takenaga, Shoko and Schneider, Benno and Erbay, E. and Biselli, Manfred and Schnitzler, Thomas and Sch{\"o}ning, Michael Josef and Wagner, Torsten}, title = {Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201532053}, pages = {1347 -- 1352}, year = {2015}, abstract = {A new microfluidic assembly method for semiconductor-based biosensors using 3D-printing technologies was proposed for a rapid and cost-efficient design of new sensor systems. The microfluidic unit is designed and printed by a 3D-printer in just a few hours and assembled on a light-addressable potentiometric sensor (LAPS) chip using a photo resin. The cell growth curves obtained from culturing cells within microfluidics-based LAPS systems were compared with cell growth curves in cell culture flasks to examine biocompatibility of the 3D-printed chips. Furthermore, an optimal cell culturing within microfluidics-based LAPS chips was achieved by adjusting the fetal calf serum concentrations of the cell culture medium, an important factor for the cell proliferation.}, language = {en} } @article{InagakiSleddensLinkelsWassenaaretal.2011, author = {Inagaki, Akiko and Sleddens-Linkels, Esther and Wassenaar, Evelyne and Ooms, Marja and Cappellen, Wiggert A. van and Hoeijmakers, Jan H. J. and Seibler, Jost and Vogt, Thomas F. and Shin, Myung K. and Grootegoed, J. Anton and Baarends, Willy M.}, title = {Meiotic functions of RAD18}, series = {Journal of Cell Science}, volume = {124}, journal = {Journal of Cell Science}, number = {16}, publisher = {Company of Biologists Limited}, address = {Cambridge}, issn = {1477-9137}, doi = {10.1242/jcs.081968}, pages = {2837 -- 2850}, year = {2011}, language = {en} } @article{RaabKappelKraemeretal.2011, author = {Raab, Monika and Kappel, Sven and Kr{\"a}mer, Andrea and Sanhaji, Mourad and Matthess, Yves and Kurunci-Csacsko, Elisabeth and Calzada-Wack, Julia and Rathkolb, Birgit and Rosman, Jan and Adler, Thure and Busch, Dirk H. and Esposito, Irene and Fuchs, Helmut and Gailus-Durner, Val{\´e}rie and Klingenspor, Martin and Wolf, Eckhard and S{\"a}nger, Nicole and Prinz, Florian and Hrabe de Angelis, Martin and Seibler, Jost and Yuan, Juping and Bergmann, Martin and Knecht, Rainald and Kreft, Bertolt and Strebhardt, Klaus}, title = {Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells}, series = {Nature Communications}, volume = {2}, journal = {Nature Communications}, number = {395}, publisher = {Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/ncomms1395}, pages = {1 -- 11}, year = {2011}, language = {en} } @article{HasegawaKapelyukhTaharaetal.2011, author = {Hasegawa, Maki and Kapelyukh, Yury and Tahara, Harunobu and Seibler, Jost and Rode, Anja and Krueger, Sylvia and Lee, Dongtao N. and Wolf, C. Roland and Scheer, Nico}, title = {Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line}, series = {Molecular Pharmacology}, volume = {80}, journal = {Molecular Pharmacology}, number = {33}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-0111}, doi = {10.1124/mol.111.071845}, pages = {518 -- 528}, year = {2011}, language = {en} } @article{JordanKruegerWillmesetal.2011, author = {Jordan, Sabine D. and Kr{\"u}ger, Markus and Willmes, Diana M. and Redemann, Nora and Wunderlich, F. Thomas and Br{\"o}nneke, Hella S. and Merkwirth, Carsten and Kashkar, Hamid and Olkkonen, Vesa M. and B{\"o}ttger, Thomas and Braun, Thomas and Seibler, Jost and Br{\"u}ning, Jens C.}, title = {Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism}, series = {Nature Cell Biology}, volume = {13}, journal = {Nature Cell Biology}, number = {4}, publisher = {Nature}, address = {New York}, issn = {1465-7392}, doi = {10.1038/ncb2211}, pages = {434 -- 446}, year = {2011}, abstract = {The contribution of altered post-transcriptional gene silencing to the development of insulin resistance and type 2 diabetes mellitus so far remains elusive. Here, we demonstrate that expression of microRNA (miR)-143 and 145 is upregulated in the liver of genetic and dietary mouse models of obesity. Induced transgenic overexpression of miR-143, but not miR-145, impairs insulin-stimulated AKT activation and glucose homeostasis. Conversely, mice deficient for the miR-143-145 cluster are protected from the development of obesity-associated insulin resistance. Quantitative-mass-spectrometry-based analysis of hepatic protein expression in miR-143-overexpressing mice revealed miR-143-dependent downregulation of oxysterol-binding-protein-related protein (ORP) 8. Reduced ORP8 expression in cultured liver cells impairs the ability of insulin to induce AKT activation, revealing an ORP8-dependent mechanism of AKT regulation. Our experiments provide direct evidence that dysregulated post-transcriptional gene silencing contributes to the development of obesity-induced insulin resistance, and characterize the miR-143-ORP8 pathway as a potential target for the treatment of obesity-associated diabetes.}, language = {en} } @article{GlaserLubitzLovelandetal.2009, author = {Glaser, Stefan and Lubitz, Sandra and Loveland, Kate L. and Ohbo, Kazu and Robb, Lorraine and Schwenk, Frieder and Seibler, Jost and Roellig, Daniela and Kranz, Andrea and Anastassiadis, Konstantinos and Stewart, A. Francis}, title = {The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis}, series = {Epigenetics \& Chromatin}, volume = {2}, journal = {Epigenetics \& Chromatin}, number = {5}, issn = {1756-8935}, doi = {10.1186/1756-8935-2-5}, pages = {1 -- 16}, year = {2009}, language = {en} } @article{KotnikPopovaTodirasetal.2009, author = {Kotnik, Katarina and Popova, Elena and Todiras, Mihail and Mori, Marcelo A. and Alenina, Natalia and Seibler, Jost and Bader, Michael}, title = {Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown}, series = {Plos One}, volume = {4}, journal = {Plos One}, number = {4}, publisher = {Plos}, address = {San Francisco, California, US}, doi = {10.1371/journal.pone.0005124}, pages = {e5124}, year = {2009}, language = {en} } @article{HeroldBrandtSeibleretal.2008, author = {Herold, Marco J. and Brandt, Jens van den and Seibler, Jost and Reichardt, Holger M.}, title = {Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats}, series = {Proceedings of the National Academy of Sciences of the United States of America}, volume = {105}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, number = {47}, issn = {1091-6490}, doi = {10.1073/pnas.0806213105}, pages = {18507 -- 18512}, year = {2008}, language = {en} } @article{KochWunderlichSeibleretal.2008, author = {Koch, Linda and Wunderlich, F. Thomas and Seibler, Jost and K{\"o}nner, A. Christine and Hampel, Brigitte and Irlenbusch, Sigrid and Brabant, Georg and Kahn, C. Ronald and Schwenk, Frieder and Br{\"u}ning, Jens C.}, title = {Central insulin action regulates peripheral glucose and fat metabolism in mice}, series = {The Journal of Clinical Investigation (JCI)}, volume = {118}, journal = {The Journal of Clinical Investigation (JCI)}, number = {6}, issn = {1558-8238}, doi = {10.1172/JCI31073}, pages = {2132 -- 2147}, year = {2008}, language = {en} } @article{ChristophBahrenbergVryetal.2008, author = {Christoph, Thomas and Bahrenberg, Gregor and Vry, Jean de and Englberger, Werner and Erdmann, Volker A. and Frech, Moritz and K{\"o}gel, Babette and R{\"o}hl, Thomas and Schiene, Klaus and Schr{\"o}der, Wolfgang and Seibler, Jost and Kurreck, Jens}, title = {Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice}, series = {Molecular and Cellular Neuroscience}, volume = {37}, journal = {Molecular and Cellular Neuroscience}, number = {3}, issn = {1044-7431}, doi = {10.1016/j.mcn.2007.12.006}, pages = {579 -- 589}, year = {2008}, language = {en} } @article{CesariRennekampffVinterstenetal.2004, author = {Cesari, Francesca and Rennekampff, Verena and Vintersten, Kristina and Vuong, Lam Giang and Seibler, Jost and Bode, J{\"u}rgen and Wiebel, Franziska F. and Nordheim, Alfred}, title = {Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange}, series = {Genesis : The Journal of Genetics and Development}, volume = {38}, journal = {Genesis : The Journal of Genetics and Development}, number = {2}, issn = {1526-968X}, doi = {10.1002/gene.20003}, pages = {87 -- 92}, year = {2004}, language = {en} } @article{BodeSchlakeIberetal.2000, author = {Bode, J{\"u}rgen and Schlake, Thomas and Iber, Michaela and Sch{\"u}beler, Dirk and Seibler, Jost and Snezhkov, Evgeney and Nikolaev, Lev}, title = {The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes}, series = {Biological Chemistry}, volume = {381}, journal = {Biological Chemistry}, number = {9-10}, issn = {1431-6730}, doi = {10.1515/BC.2000.103}, pages = {801 -- 813}, year = {2000}, language = {en} } @article{FengSeiblerAlamietal.1999, author = {Feng, Yong-Qing and Seibler, Jost and Alami, Raouf and Eisen, Andrew and Westerman, Karen A. and Leboulch, Philippe and Fiering, Steven and Bouhassira, Eric E.}, title = {Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange}, series = {Journal of Molecular Biology}, volume = {292}, journal = {Journal of Molecular Biology}, number = {4}, issn = {0022-2836}, doi = {10.1006/jmbi.1999.3113}, pages = {779 -- 785}, year = {1999}, language = {en} } @article{SeiblerSchuebelerFieringetal.1998, author = {Seibler, Jost and Sch{\"u}beler, Dirk and Fiering, Steven and Groudine, Mark and Bode, J{\"u}rgen}, title = {DNA cassette exchange in ES cells mediated by Flp recombinase: an efficient strategy for repeated modification of tagged loci by marker-free constructs}, series = {Biochemistry}, volume = {37}, journal = {Biochemistry}, number = {18}, issn = {1520-4995}, doi = {10.1021/bi980288t}, pages = {6229 -- 6234}, year = {1998}, language = {en} } @article{SeiblerBode1997, author = {Seibler, Jost and Bode, J{\"u}rgen}, title = {Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay}, series = {Biochemistry}, volume = {36}, journal = {Biochemistry}, number = {7}, issn = {1520-4995}, pages = {1740 -- 1747}, year = {1997}, language = {en} } @article{IberSchuebelerSeibleretal.1998, author = {Iber, Michaela and Sch{\"u}beler, Dirk and Seibler, Jost and H{\"o}xter, Maria and Bode, J{\"u}rgen}, title = {Efficient FACS selection procedure for cells undergoing Flp-mediated site-specific conversions}, series = {Technical Tips Online}, volume = {4}, journal = {Technical Tips Online}, number = {1}, doi = {10.1016/S1366-2120(08)70132-6}, pages = {25 -- 29}, year = {1998}, language = {en} } @article{HenkenOosterhuisOehlschlaegeretal.2012, author = {Henken, F. E. and Oosterhuis, K. and {\"O}hlschl{\"a}ger, Peter and Bosch, L. and Hooijberg, E. and Haanen, J. B. A. G. and Steenbergen, R. D. M.}, title = {Preclinical safety evaluation of DNA vaccines encoding modified HPV16 E6 and E7}, series = {Vaccine}, volume = {30}, journal = {Vaccine}, number = {28}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0264-410X}, doi = {10.1016/j.vaccine.2012.04.013}, pages = {4259 -- 4266}, year = {2012}, abstract = {Persistent infection with high-risk human papillomaviruses (hrHPV) can result in the formation of anogenital cancers. As hrHPV proteins E6 and E7 are required for cancer initiation and maintenance, they are ideal targets for immunotherapeutic interventions. Previously, we have described the development of DNA vaccines for the induction of HPV16 E6 and E7 specific T cell immunity. These vaccines consist of 'gene-shuffled' (SH) versions of HPV16 E6 and E7 that were fused to Tetanus Toxin Fragment C domain 1 (TTFC) and were named TTFC-E6SH and TTFC-E7SH. Gene-shuffling was performed to avoid the risk of inducing malignant transformation at the vaccination site. Here, we describe the preclinical safety evaluation of these candidate vaccines by analysis of their transforming capacity in vitro using established murine fibroblasts (NIH 3T3 cells) and primary human foreskin keratinocytes (HFKs). We demonstrate that neither ectopic expression of TTFC-E6SH and TTFC-E7SH alone or in combination enabled NIH 3T3 cells to form colonies in soft agar. In contrast, expression of HPV16 E6WT and E7WT alone or in combination resulted in effective transformation. Similarly, retroviral transduction of HFKs from three independent donors with both TTFC-E6SH and TTFC-E7SH alone or in combination did not show any signs of immortalization. In contrast, the combined expression of E6WT and E7WT induced immortalization in HFKs from all donors. Based on these results we consider it justified to proceed to clinical evaluation of DNA vaccines encoding TTFC-E6SH and TTFC-E7SH in patients with HPV16 associated (pre)malignancies.}, language = {en} } @article{ImmelGruetzkeSpaeteetal.2012, author = {Immel, Timo and Gr{\"u}tzke, Martin and Sp{\"a}te, Anne-Katrin and Groth, Ulrich and {\"O}hlschl{\"a}ger, Peter and Huhn, Thomas}, title = {Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy}, series = {Chemical Communications}, volume = {48}, journal = {Chemical Communications}, number = {46}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1364-548X}, doi = {10.1039/C2CC31624B}, pages = {5790 -- 5792}, year = {2012}, abstract = {Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.}, language = {en} } @article{FellinKingKirschetal.2010, author = {Fellin, Wolfgang and King, Julian and Kirsch, Ansgar and Oberguggenberger, Michael}, title = {Uncertainty modelling and sensitivity analysis of tunnel face stability}, series = {Structural safety}, volume = {32}, journal = {Structural safety}, number = {6}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0167-4730}, doi = {10.1016/j.strusafe.2010.06.001}, pages = {402 -- 410}, year = {2010}, abstract = {This paper proposes an approach to the choice and evaluation of engineering models with the aid of a typical application in geotechnics. An important issue in the construction of shallow tunnels, especially in weak ground conditions, is the tunnel face stability. Various theoretical and numerical models for predicting the necessary support pressure have been put forth in the literature. In this paper, we combine laboratory experiments performed at the University of Innsbruck with current methods of uncertainty and sensitivity analysis for assessing adequacy, predictive power and robustness of the models. The major issues are the handling of the twofold uncertainty of test results and of model predictions as well as the decision about what are the influential input parameters.}, language = {en} } @article{Kirsch2010, author = {Kirsch, Ansgar}, title = {Experimental investigation of the face stability of shallow tunnels in sand}, series = {Acta Geotechnica}, volume = {5}, journal = {Acta Geotechnica}, number = {1}, publisher = {Springer}, address = {Berlin}, issn = {1861-1125}, doi = {10.1007/s11440-010-0110-7}, pages = {43 -- 62}, year = {2010}, abstract = {Various models have been proposed for the prediction of the necessary support pressure at the face of a shallow tunnel. To assess their quality, the collapse of a tunnel face was modelled with small-scale model tests at single gravity. The development of the failure mechanism and the support force at the face in dry sand were investigated. The observed displacement patterns show a negligible influence of overburden on the extent and evolution of the failure zone. The latter is significantly influenced, though, by the initial density of the sand: in dense sand a chimney-wedge-type collapse mechanism developed, which propagated towards the soil surface. Initially, loose sand did not show any discrete collapse mechanism. The necessary support force was neither influenced by the overburden nor the initial density. A comparison with quantitative predictions by several theoretical models showed that the measured necessary support pressure is overestimated by most of the models. Those by Vermeer/Ruse and L{\´e}ca/Dormieux showed the best agreement to the measurements.}, language = {en} } @article{KolymbasKirsch2009, author = {Kolymbas, Dimitrios and Kirsch, Ansgar}, title = {Zum Erddruck auf Lawinenschutzgalerien}, series = {Bautechnik : Zeitschrift f{\"u}r den gesamten Ingenieurbau}, volume = {Vol. 86}, journal = {Bautechnik : Zeitschrift f{\"u}r den gesamten Ingenieurbau}, number = {Iss. 12}, issn = {1437-0999 (E-Journal); 0005-6820 (Print); 0932-8351 (Print)}, doi = {10.1002/bate.200910075}, pages = {774 -- 779}, year = {2009}, language = {de} } @article{KirschPiazzi2009, author = {Kirsch, Ansgar and Piazzi, Lukas}, title = {Numerical investigation of the effectiveness of a bored pile wall for the minimisation of settlement resulting from tunnel driving}, series = {Geomechanics and tunnelling}, volume = {Vol. 2}, journal = {Geomechanics and tunnelling}, number = {Iss. 6}, issn = {1865-7362}, doi = {10.1002/geot.200900063}, pages = {753 -- 765}, year = {2009}, language = {de} } @article{Kirsch2008, author = {Kirsch, Ansgar}, title = {Experimentelle Untersuchung des Ortsbrustversagens seichter Tunnel}, series = {{\"O}sterreichische Bauwirtschaft}, journal = {{\"O}sterreichische Bauwirtschaft}, number = {Sondernr.}, pages = {6 -- 9}, year = {2008}, language = {de} } @article{KolymbasFellinKirsch2006, author = {Kolymbas, Dimitrios and Fellin, W. and Kirsch, Ansgar}, title = {Squeezing due to stress relaxation in foliated rock}, series = {International journal for numerical and analytical methods in geomechanics}, volume = {Vol. 30}, journal = {International journal for numerical and analytical methods in geomechanics}, number = {Iss. 13}, issn = {1096-9853 (E-Journal); 0363-9061 (Print)}, doi = {10.1002/nag.530}, pages = {1357 -- 1367}, year = {2006}, language = {en} } @article{ScheerSnaithWolfetal.2013, author = {Scheer, Nico and Snaith, Mike and Wolf, C. Roland and Seibler, Jost}, title = {Generation and utility of genetically humanized mouse models}, series = {Drug Discovery Today}, volume = {Vol 18}, journal = {Drug Discovery Today}, number = {23-24}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1359-6446}, doi = {10.1016/j.drudis.2013.07.007}, pages = {1200 -- 1211}, year = {2013}, language = {en} } @article{BouwmanGuldenHeijdenetal.2013, author = {Bouwman, Peter and Gulden, Hanneke van der and Heijden, Ingrid van der and Drost, Rinske and Klijn, Christiaan N. and Prasetyanti, Pramudita and Pieterse, Mark and Wientjens, Ellen and Seibler, Jost and Hogervorst, Frank B. L. and Jonkers, Jos}, title = {A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants}, series = {Cancer Discovery}, journal = {Cancer Discovery}, number = {3}, issn = {2159-8290}, doi = {10.1158/2159-8290.CD-13-0094}, pages = {1142 -- 1152}, year = {2013}, language = {en} } @article{MichalakNacerddinePietersenetal.2013, author = {Michalak, Ewa Malgorzata and Nacerddine, Karim and Pietersen, Alexandra and Beuger, Vincent and Pawlitzky, Inka and Cornelissen-Steijger, Paulien and Wientjens, Ellen and Tanger, Ellen and Seibler, Jost and Lohuizen, Maarten van and Jonkers, Jos}, title = {Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool}, series = {Stem Cells}, volume = {Vol 31}, journal = {Stem Cells}, number = {9}, publisher = {Oxford University Press}, address = {Oxford}, issn = {1549-4918}, doi = {10.1002/stem.1437}, pages = {1910 -- 1920}, year = {2013}, language = {en} } @article{GebeshuberKornauthDongetal.2013, author = {Gebeshuber, Christoph A. and Kornauth, Christoph and Dong, Lihua and Sierig, Ralph and Seibler, Jost and Reiss, Martina and Tauber, Stefanie and Bilban, Martin and Wang, Shijun and Kain, Renate and B{\"o}hmig, Georg A. and Moeller, Marcus J. and Gr{\"o}ne, Hermann-Josef and Englert, Christoph and Martinez, Javier and Kerjaschki, Dontscho}, title = {Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1}, series = {Nature Medicine}, volume = {19}, journal = {Nature Medicine}, number = {4}, issn = {1078-8956}, doi = {10.1038/nm.3142}, pages = {481 -- 487}, year = {2013}, language = {en} } @article{KornfeldBaitzelKoenneretal.2013, author = {Kornfeld, Jan-Wilhelm and Baitzel, Catherina and K{\"o}nner, A. Christine and Nicholls, Hayley T. and Vogt, Merly C. and Herrmanns, Karolin and Scheja, Ludger and Haumaitre, C{\´e}cile and Wolf, Anna M. and Knippschild, Uwe and Seibler, Jost and Cereghini, Silvia and Heeren, Joerg and Stoffel, Markus and Br{\"u}ning, Jens C.}, title = {Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b}, series = {Nature}, volume = {494}, journal = {Nature}, number = {7435}, publisher = {Springer Nature}, address = {Cham}, isbn = {0028-0836}, doi = {10.1038/nature11793}, pages = {111 -- 115}, year = {2013}, language = {en} } @article{Wollert2008, author = {Wollert, J{\"o}rg}, title = {Bluetooth: Funk f{\"u}r alle(s)? : 10 Jahre Bluetooth: ein Technologie-{\"U}ber- und -Ausblick}, series = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme}, journal = {Elektronik : Fachmedium f{\"u}r industrielle Anwender und Entwickler ; Sonderh. Wireless : Fachmedium f{\"u}r Entwicklungen funkbasierter Systeme}, number = {Okt.}, pages = {36 -- 43}, year = {2008}, language = {de} } @article{OberlaenderKirchnerKeusgenetal.2015, author = {Oberl{\"a}nder, Jan and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Strategies in developing thin-film sensors for monitoring aseptic food processes : Theoretical considerations and investigations of passivation materials}, series = {Electrochimica Acta}, volume = {183}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2015.06.126}, pages = {130 -- 136}, year = {2015}, abstract = {The sterilization of packages in aseptic food processes is highly significant to maintain a consumer-safe product with extended shelf-life. Today, the sterilization of food packages is predominantly accomplished by gaseous hydrogen peroxide (H2O2) in combination with heat. In order to monitor this sterilization process, calorimetric gas sensors as differential set-up of two platinum temperature sensors representing a catalytically active (additionally deposition of MnO2) and a passive segment have been recently developed. The temperature rise of the exothermic decomposition serves as an indicator of the present H2O2 concentration. In the present work, a theoretical approach considering the sensor's thermochemistry and physical transport phenomena was formulated to evaluate the temperature rise based on the energy content of gaseous H2O2. In a further part of this work, three polymers have been analyzed with respect to their application as passivation materials. The examined polymers are photoresist SU-8, perfluoroalkoxy (PFA) and fluorinated ethylene propylene (FEP). Thermal analyses by means of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) have been conducted to determine the operation limits of the polymers. The overall chemical resistance and stability of the polymers against the harsh environmental conditions during the sterilization process have been examined by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR).}, language = {en} } @article{KuperjansWeitzel2015, author = {Kuperjans, Isabel and Weitzel, J.}, title = {Energiedesign 2020 : Sichere Strom- und W{\"a}rmeversorgung f{\"u}r die Industrie}, series = {TAB: das Fachmedium der TGA-Branche}, journal = {TAB: das Fachmedium der TGA-Branche}, number = {3}, publisher = {Bauverlag}, address = {G{\"u}tersloh}, issn = {0341-2032}, pages = {105 -- 107}, year = {2015}, language = {de} } @article{HoevelerJanserBindewaldetal.2015, author = {Hoeveler, Bastian and Janser, Frank and Bindewald, Thorsten and Gebhardt, Andreas}, title = {Entwurf, Fertigung und Untersuchung eines Windkanalmodells eines innovativen, senkrechtstartenden Kleinflugzeuges}, series = {RTejournal - Forum f{\"u}r Rapid Technologie}, journal = {RTejournal - Forum f{\"u}r Rapid Technologie}, number = {12}, publisher = {Fachhochschule Aachen}, address = {Aachen}, issn = {1614-0923}, url = {http://nbn-resolving.de/urn:nbn:de:0009-2-42921}, pages = {1 -- 5}, year = {2015}, language = {de} } @article{Wollert2015, author = {Wollert, J{\"o}rg}, title = {IO-Link - f{\"u}r smarte Sensoren}, series = {elektroniknet.de}, journal = {elektroniknet.de}, year = {2015}, language = {de} } @article{Wollert2015, author = {Wollert, J{\"o}rg}, title = {Echtzeit-Ethernet : Protokoll-Reigen}, series = {elektroniknet.de}, journal = {elektroniknet.de}, year = {2015}, language = {de} } @article{MiyamatoSakakitaWagneretal.2015, author = {Miyamato, Ko-ichiro and Sakakita, Sakura and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Application of chemical imaging sensor to in-situ pH imaging in the vicinity of a corroding metal surface}, series = {Electrochimica Acta}, volume = {183}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0013-4686}, doi = {10.1016/j.electacta.2015.07.184}, pages = {137 -- 142}, year = {2015}, abstract = {The chemical imaging sensor was applied to in-situ pH imaging of the solution in the vicinity of a corroding surface of stainless steel under potentiostatic polarization. A test piece of polished stainless steel was placed on the sensing surface leaving a narrow gap filled with artificial seawater and the stainless steel was corroded under polarization. The pH images obtained during polarization showed correspondence between the region of lower pH and the site of corrosion. It was also found that the pH value in the gap became as low as 2 by polarization, which triggered corrosion.}, language = {en} } @article{HamadBilattoAdlyetal.2016, author = {Hamad, E. M. and Bilatto, S. E. R. and Adly, N. Y. and Correa, D. S. and Wolfrum, B. and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, A. and Yakushenko, A.}, title = {Inkjet printing of UV-curable adhesive and dielectric inks for microfluidic devices}, series = {Lab on a Chip}, volume = {16}, journal = {Lab on a Chip}, number = {1}, publisher = {Royal Society of Chemistry}, address = {Cambridge}, issn = {1473-0189}, doi = {10.1039/C5LC01195G}, pages = {70 -- 74}, year = {2016}, abstract = {Bonding of polymer-based microfluidics to polymer substrates still poses a challenge for Lab-On-a-Chip applications. Especially, when sensing elements are incorporated, patterned deposition of adhesives with curing at ambient conditions is required. Here, we demonstrate a fabrication method for fully printed microfluidic systems with sensing elements using inkjet and stereolithographic 3D-printing.}, language = {en} } @article{HauserKotliarTholenetal.2015, author = {Hauser, C. and Kotliar, Konstantin and Tholen, S. and Hasenau, A. and Suttmann, Y. and Renders, L. and Heemann, U. and Baumann, M. and Schmaderer, C.}, title = {Dynamische retinale Gef{\"a}ßreaktion bei H{\"a}modialysepatienten}, series = {Nieren- und Hochdruckkrankheiten}, volume = {44}, journal = {Nieren- und Hochdruckkrankheiten}, number = {11}, publisher = {Dustri-Verlag}, address = {Oberhaching}, issn = {0300-5224}, doi = {10.5414/NHX01743a}, pages = {480 -- 480}, year = {2015}, language = {de} } @article{Gebhardt2015, author = {Gebhardt, Andreas}, title = {3D-Druck ist {\"u}berall. Modische Accessoires, Kleidung, Medikamente, Nahrungsmittel, Autos, H{\"a}user, Waffen, B{\"u}sten, Musikinstrumente - alles geht}, series = {Kunststoffe}, volume = {105}, journal = {Kunststoffe}, number = {10}, publisher = {Hanser}, address = {M{\"u}nchen}, issn = {0023-5563}, pages = {62 -- 70}, year = {2015}, language = {de} } @article{FischerSelverGezeretal.2015, author = {Fischer, Felix and Selver, M. Alper and Gezer, Sinem and Dicle, Oguz and Hillen, Walter}, title = {Systematic Parameterization, Storage, and Representation of Volumetric DICOM Data}, series = {Journal of Medical and Biological Engineering}, volume = {35}, journal = {Journal of Medical and Biological Engineering}, number = {6}, publisher = {Springer}, address = {Berlin}, issn = {2199-4757}, doi = {10.1007/s40846-015-0097-5}, pages = {709 -- 723}, year = {2015}, language = {en} } @article{FredebeulKrein2015, author = {Fredebeul-Krein, Markus}, title = {Volkswirtschaftslehre : Die Klausur}, series = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Pr{\"u}fung, Berufseinstieg und Fortbildung}, volume = {45}, journal = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Pr{\"u}fung, Berufseinstieg und Fortbildung}, number = {11}, publisher = {Lange}, address = {D{\"u}sseldorf}, issn = {0340-3084}, pages = {1253 -- 1255}, year = {2015}, language = {de} } @article{FredebeulKrein2015, author = {Fredebeul-Krein, Markus}, title = {Wettbewerbspolitische Leitbilder}, series = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Examen, Berufseinstieg und Fortbildung}, volume = {45}, journal = {Das Wirtschaftsstudium : wisu ; Zeitschrift f{\"u}r Ausbildung, Examen, Berufseinstieg und Fortbildung}, number = {4}, publisher = {Lange}, address = {D{\"u}sseldorf}, issn = {0340-3084}, pages = {483 -- 486}, year = {2015}, language = {de} } @article{FredebeulKrein2016, author = {Fredebeul-Krein, Markus}, title = {Warum staatliche Kaufpr{\"a}mien f{\"u}r Elektroautos abzulehnen sind}, series = {Wirtschaftliche Freiheit : das ordnungspolitische Journal}, volume = {2016}, journal = {Wirtschaftliche Freiheit : das ordnungspolitische Journal}, number = {4}, publisher = {Alexander B. Brunner}, address = {W{\"u}rzburg}, year = {2016}, abstract = {Im Jahr 2015 wurden in Deutschland {\"u}ber drei Millionen Benzinautos und lediglich 12.363 Elektroautos neu zugelassen. Das urspr{\"u}nglich von der Bundesregierung vorgegebene Ziel, dass bis 2020 eine Million E-Autos auf deutschen Straßen fahren (und bis 2030 sechs Millionen), r{\"u}ckt damit in immer weitere Ferne. Um das Ziel dennoch zu erreichen, plant die Bundesregierung nun eine staatli­che Pr{\"a}mie f{\"u}r den Kauf von Elektroautos: Umwelt-, Verkehrs- und Wirtschaftsministerium haben gemeinsam ein Konzept entworfen, dem zufolge private K{\"a}ufer zuk{\"u}nftig einen Zuschuss von 5.000 Euro beim Erwerb eines Elektroautos bekommen sollen. 40 Prozent dieses Zuschusses soll von den Autoherstellern getragen werden. Das Programm, das weitere ausgabenwirksame {\"o}ffentli­che Maßnahmen vorsieht, w{\"u}rde Kosten in Milliarden­h{\"o}he verursachen. Die beabsichtigte Subventionierung wirft die Frage auf, ob diese wirtschaftlich sinnvoll sind.}, language = {de} } @article{BayonValeroGarciaBartualetal.2016, author = {Bayon, Arnau and Valero, Daniel and Garcia-Bartual, Rafael and Vall{\´e}s-Mor{\´a}n, Francisco Jos{\´e} and L{\´o}pez-Jim{\´e}nez, P. Amparo}, title = {Performance assessment of OpenFOAM and FLOW-3D in the numerical modeling of a low Reynolds number hydraulic jump}, series = {Environmental Modelling \& Software}, volume = {80}, journal = {Environmental Modelling \& Software}, publisher = {Elsevier}, address = {Amsterdam}, isbn = {1364-8152}, doi = {10.1016/j.envsoft.2016.02.018}, pages = {322 -- 335}, year = {2016}, abstract = {A comparative performance analysis of the CFD platforms OpenFOAM and FLOW-3D is presented, focusing on a 3D swirling turbulent flow: a steady hydraulic jump at low Reynolds number. Turbulence is treated using RANS approach RNG k-ε. A Volume Of Fluid (VOF) method is used to track the air-water interface, consequently aeration is modeled using an Eulerian-Eulerian approach. Structured meshes of cubic elements are used to discretize the channel geometry. The numerical model accuracy is assessed comparing representative hydraulic jump variables (sequent depth ratio, roller length, mean velocity profiles, velocity decay or free surface profile) to experimental data. The model results are also compared to previous studies to broaden the result validation. Both codes reproduced the phenomenon under study concurring with experimental data, although special care must be taken when swirling flows occur. Both models can be used to reproduce the hydraulic performance of energy dissipation structures at low Reynolds numbers.}, language = {en} } @article{MiyamotoYuIsodaetal.2016, author = {Miyamoto, Ko-ichiro and Yu, Bing and Isoda, Hiroko and Wagner, Torsten and Sch{\"o}ning, Michael Josef and Yoshinobu, Tatsuo}, title = {Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor}, series = {Sensors and Actuators B: Chemical}, volume = {236}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.04.018}, pages = {965 -- 969}, year = {2016}, abstract = {The chemical imaging sensor is a field-effect sensor which is able to visualize both the distribution of ions (in LAPS mode) and the distribution of impedance (in SPIM mode) in the sample. In this study, a novel cell assay is proposed, in which the chemical imaging sensor operated in SPIM mode is applied to monitor the recovery of defects in a cell layer brought into proximity of the sensing surface. A reduced impedance at a defect formed artificially in a cell layer was successfully visualized in a photocurrent image. The cell layer was cultured over two weeks, during which the temporal change of the photocurrent distribution corresponding to the recovery of the defect was observed.}, language = {de} } @article{DantismTakenagaWagneretal.2016, author = {Dantism, Shahriar and Takenaga, Shoko and Wagner, Patrick and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system}, series = {Physica status solidi (a)}, volume = {213}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.201533043}, pages = {1479 -- 1485}, year = {2016}, abstract = {On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable "down times" during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements.}, language = {en} } @article{Wollert2016, author = {Wollert, J{\"o}rg}, title = {Rapid Application Development}, series = {Design \& Elektronik}, journal = {Design \& Elektronik}, number = {4}, publisher = {WEKA-Fachmedien}, address = {M{\"u}nchen}, issn = {0933-8667}, pages = {8 -- 11}, year = {2016}, abstract = {Das IoT ist ohne eingebettete Systeme undenkbar. Erst kleine und kleinste Mikrocontroller mit intelligenten Kommunikationsschnittstellen und Anbindung ans Internet erm{\"o}glichen sinnvolles und fl{\"a}chendeckendes Einsammeln von Daten. Doch wie kompliziert ist der Einstieg in die Embedded-Welt? Dieser Artikel gibt Einblick, wie die »Arduino-Plattform« die Einstiegsh{\"u}rden f{\"u}r eingebettete Systeme dramatisch reduzieren kann.}, language = {de} } @article{Wollert2016, author = {Wollert, J{\"o}rg}, title = {Industrial Internet of Things : Seifenblase oder Revolution}, series = {Elektronik}, journal = {Elektronik}, number = {7}, publisher = {WEKA-Fachmedien}, address = {M{\"u}nchen}, issn = {0013-5658}, pages = {39 -- 45}, year = {2016}, language = {de} } @article{BreuerRaueStrobeletal.2016, author = {Breuer, Lars and Raue, Markus and Strobel, M. and Mang, Thomas and Sch{\"o}ning, Michael Josef and Thoelen, R. and Wagner, Torsten}, title = {Hydrogels with incorporated graphene oxide as light-addressable actuator materials for cell culture environments in lab-on-chip systems}, series = {Physica status solidi (a)}, volume = {213}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1862-6300}, doi = {10.1002/pssa.201533056}, pages = {1520 -- 1525}, year = {2016}, abstract = {Abstractauthoren Graphene oxide (GO) nanoparticles were incorporated in temperature-sensitive Poly(N-isopropylacrylamide) (PNIPAAm) hydrogels. The nanoparticles increase the light absorption and convert light energy into heat efficiently. Thus, the hydrogels with GO can be stimulated spatially resolved by illumination as it was demonstrated by IR thermography. The temporal progression of the temperature maximum was detected for different concentrations of GO within the polymer network. Furthermore, the compatibility of PNIPAAm hydrogels with GO and cell cultures was investigated. For this purpose, culture medium was incubated with hydrogels containing GO and the viability and morphology of chinese hamster ovary (CHO) cells was examined after several days of culturing in presence of this medium.}, language = {en} } @article{PookhalilAmoabedinyTabeshetal.2016, author = {Pookhalil, Ali and Amoabediny, Ghassem and Tabesh, Hadi and Behbahani, Mehdi and Mottaghy, Khosrow}, title = {A new approach for semiempirical modeling of mechanical blood trauma}, series = {The international journal of artificial organs}, volume = {39}, journal = {The international journal of artificial organs}, number = {4}, publisher = {Sage}, address = {London}, issn = {1724-6040}, doi = {10.5301/ijao.5000474}, pages = {171 -- 177}, year = {2016}, abstract = {Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.}, language = {en} } @article{Lind2016, author = {Lind, Thorsten Patric}, title = {Insolvenzanfechtung: Keine Gl{\"a}ubigerbenachteiligung bei Abl{\"o}sezahlung gegen Forderungsverzicht}, series = {Der Betrieb}, volume = {69}, journal = {Der Betrieb}, number = {17}, publisher = {Fachmedien Otto Schmidt}, address = {D{\"u}sseldorf}, issn = {0005-9935}, pages = {999 -- 1001}, year = {2016}, abstract = {Schwerpunkt einer vorinsolvenzlichen Sanierung ist i.d.R., dass einzelne Gl{\"a}ubiger gegen Teilzahlungen auf ihre Forderungen verzichten und somit dem Unternehmen den notwendigen finanziellen Freiraum f{\"u}r einen Turnaround geben. Die Motivation der Gl{\"a}ubiger f{\"u}r einen Verzicht ist dabei auch die {\"U}berlegung, dass eine quotale Befriedigung im Rahmen eines Insolvenzverfahrens oft wesentlich geringer ausfallen w{\"u}rde als die durch den Vergleich realisierte Teilzahlung. Das Risiko, im Falle der Insolvenz eine Teilzahlung im Rahmen der Insolvenzanfechtung aber wieder zur{\"u}ckgew{\"a}hren zu m{\"u}ssen, macht einen Forderungsverzicht weniger attraktiv. Mit Urteil vom 28.01.2016 hat der BGH nun entschieden, dass eine Insolvenzanfechtung mangels Gl{\"a}ubigerbenachteiligung ausscheidet, wenn der in der Teilzahlung liegende Verm{\"o}gensverlust durch den damit verbundenen Verzicht auf die Restforderung voll ausgeglichen wird. Im Folgenden wird untersucht, ob dieses Urteil als Blaupause f{\"u}r eine anfechtungsfeste Restrukturierung einzelner Verbindlichkeiten dienen kann.}, language = {de} } @article{BertzSchoeningMolinnusetal.2024, author = {Bertz, Morten and Sch{\"o}ning, Michael Josef and Molinnus, Denise and Homma, Takayuki}, title = {Influence of temperature, light, and H₂O₂ concentration on microbial spore inactivation: in-situ Raman spectroscopy combined with optical trapping}, series = {Physica status solidi (a) applications and materials science}, journal = {Physica status solidi (a) applications and materials science}, number = {Early View}, publisher = {Wiley-VCH}, address = {Berlin}, issn = {1862-6319 (Online)}, doi = {10.1002/pssa.202300866}, pages = {8 Seiten}, year = {2024}, abstract = {To gain insight on chemical sterilization processes, the influence of temperature (up to 70 °C), intense green light, and hydrogen peroxide (H₂O₂) concentration (up to 30\% in aqueous solution) on microbial spore inactivation is evaluated by in-situ Raman spectroscopy with an optical trap. Bacillus atrophaeus is utilized as a model organism. Individual spores are isolated and their chemical makeup is monitored under dynamically changing conditions (temperature, light, and H₂O₂ concentration) to mimic industrially relevant process parameters for sterilization in the field of aseptic food processing. While isolated spores in water are highly stable, even at elevated temperatures of 70 °C, exposure to H₂O₂ leads to a loss of spore integrity characterized by the release of the key spore biomarker dipicolinic acid (DPA) in a concentration-dependent manner, which indicates damage to the inner membrane of the spore. Intensive light or heat, both of which accelerate the decomposition of H₂O₂ into reactive oxygen species (ROS), drastically shorten the spore lifetime, suggesting the formation of ROS as a rate-limiting step during sterilization. It is concluded that Raman spectroscopy can deliver mechanistic insight into the mode of action of H₂O₂-based sterilization and reveal the individual contributions of different sterilization methods acting in tandem.}, language = {en} } @article{SchoenrockMuckeltHastermannetal.2024, author = {Schoenrock, Britt and Muckelt, Paul E. and Hastermann, Maria and Albracht, Kirsten and MacGregor, Robert and Martin, David and Gunga, Hans-Christian and Salanova, Michele and Stokes, Maria J. and Warner, Martin B. and Blottner, Dieter}, title = {Muscle stiffness indicating mission crew health in space}, series = {Scientific Reports}, volume = {14}, journal = {Scientific Reports}, number = {Article number: 4196}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-024-54759-6}, pages = {13 Seiten}, year = {2024}, abstract = {Muscle function is compromised by gravitational unloading in space affecting overall musculoskeletal health. Astronauts perform daily exercise programmes to mitigate these effects but knowing which muscles to target would optimise effectiveness. Accurate inflight assessment to inform exercise programmes is critical due to lack of technologies suitable for spaceflight. Changes in mechanical properties indicate muscle health status and can be measured rapidly and non-invasively using novel technology. A hand-held MyotonPRO device enabled monitoring of muscle health for the first time in spaceflight (> 180 days). Greater/maintained stiffness indicated countermeasures were effective. Tissue stiffness was preserved in the majority of muscles (neck, shoulder, back, thigh) but Tibialis Anterior (foot lever muscle) stiffness decreased inflight vs. preflight (p < 0.0001; mean difference 149 N/m) in all 12 crewmembers. The calf muscles showed opposing effects, Gastrocnemius increasing in stiffness Soleus decreasing. Selective stiffness decrements indicate lack of preservation despite daily inflight countermeasures. This calls for more targeted exercises for lower leg muscles with vital roles as ankle joint stabilizers and in gait. Muscle stiffness is a digital biomarker for risk monitoring during future planetary explorations (Moon, Mars), for healthcare management in challenging environments or clinical disorders in people on Earth, to enable effective tailored exercise programmes.}, language = {en} } @article{PolenKraemerBongaertsetal.2005, author = {Polen, T. and Kr{\"a}mer, Marco and Bongaerts, Johannes and Wubbolts, Marcel and Wendisch, V. F.}, title = {The global gene expression response of Escherichia coli to L-phenylalanine}, series = {Journal of biotechnology}, volume = {Vol. 115}, journal = {Journal of biotechnology}, number = {Iss. 3}, issn = {1873-4863 (E-Journal); 0168-1656 (Print)}, pages = {221 -- 237}, year = {2005}, language = {en} } @article{BongaertsKraemerMuelleretal.2001, author = {Bongaerts, Johannes and Kr{\"a}mer, Marco and M{\"u}ller, Ulrike and Raeven, Leon and Wubbolts, Marcel}, title = {Metabolic engineering for microbial production of aromatic amino acids and derived compounds}, series = {Metabolic engineering}, volume = {Vol. 3}, journal = {Metabolic engineering}, number = {Iss. 4}, issn = {1096-7184 (E-Journal); 1096-7176 (Print)}, pages = {289 -- 300}, year = {2001}, language = {en} } @article{AbbasBalcBremenetal.2022, author = {Abbas, Karim and Balc, Nicolae and Bremen, Sebastian and Skupin, Marco}, title = {Crystallization and aging behavior of polyetheretherketone PEEK within rapid tooling and rubber molding}, series = {Journal of Manufacturing and Materials Processing}, volume = {6}, journal = {Journal of Manufacturing and Materials Processing}, number = {5}, publisher = {MDPI}, address = {Basel}, issn = {2504-4494}, doi = {10.3390/jmmp6050093}, pages = {1 -- 12}, year = {2022}, abstract = {In times of short product life cycles, additive manufacturing and rapid tooling are important methods to make tool development and manufacturing more efficient. High-performance polymers are the key to mold production for prototypes and small series. However, the high temperatures during vulcanization injection molding cause thermal aging and can impair service life. The extent to which the thermal stress over the entire process chain stresses the material and whether it leads to irreversible material aging is evaluated. To this end, a mold made of PEEK is fabricated using fused filament fabrication and examined for its potential application. The mold is heated to 200 ◦C, filled with rubber, and cured. A differential scanning calorimetry analysis of each process step illustrates the crystallization behavior and first indicates the material resistance. It shows distinct cold crystallization regions at a build chamber temperature of 90 ◦C. At an ambient temperature above Tg, crystallization of 30\% is achieved, and cold crystallization no longer occurs. Additional tensile tests show a decrease in tensile strength after ten days of thermal aging. The steady decrease in recrystallization temperature indicates degradation of the additives. However, the tensile tests reveal steady embrittlement of the material due to increasing crosslinking.}, language = {en} } @article{Bung2024, author = {Bung, Daniel Bernhard}, title = {Kamerabasierte Fließtiefen- und Geschwindigkeitsmessungen}, series = {Wasserwirtschaft}, volume = {114}, journal = {Wasserwirtschaft}, number = {4}, publisher = {Springer Vieweg}, address = {Wiesbaden}, issn = {0043-0978}, pages = {47 -- 53}, year = {2024}, abstract = {In der wasserbaulichen Forschung werden neben klassischen Messinstrumenten zunehmend kamerabasierte Verfahren genutzt. Diese erlauben neben der Bestimmung von Fließgeschwindigkeiten auch die Detektion der freien Wasseroberfl{\"a}che oder zeitliche Vermessung von Kolken. Durch die hohen r{\"a}umlichen und zeitlichen Aufl{\"o}sungen, welche neueste Kamerasensoren liefern, k{\"o}nnen neue Erkenntnisse in turbulenten, komplexen Str{\"o}mungen gewonnen werden. Auch in der Praxis k{\"o}nnen diese Verfahren mit geringem Aufwand wichtige Daten liefern.}, language = {de} } @article{FunkeBeckmann2022, author = {Funke, Harald and Beckmann, Nils}, title = {Flexible fuel operation of a Dry-Low-NOx Micromix Combustor with Variable Hydrogen Methane Mixture}, series = {International Journal of Gas Turbine, Propulsion and Power Systems}, volume = {13}, journal = {International Journal of Gas Turbine, Propulsion and Power Systems}, number = {2}, issn = {1882-5079}, pages = {1 -- 7}, year = {2022}, abstract = {The role of hydrogen (H2) as a carbon-free energy carrier is discussed since decades for reducing greenhouse gas emissions. As bridge technology towards a hydrogen-based energy supply, fuel mixtures of natural gas or methane (CH4) and hydrogen are possible. The paper presents the first test results of a low-emission Micromix combustor designed for flexible-fuel operation with variable H2/CH4 mixtures. The numerical and experimental approach for considering variable fuel mixtures instead of recently investigated pure hydrogen is described. In the experimental studies, a first generation FuelFlex Micromix combustor geometry is tested at atmospheric pressure at gas turbine operating conditions corresponding to part- and full-load. The H2/CH4 fuel mixture composition is varied between 57 and 100 vol.\% hydrogen content. Despite the challenges flexible-fuel operation poses onto the design of a combustion system, the evaluated FuelFlex Micromix prototype shows a significant low NOx performance}, language = {en} } @article{EdipSesovButenwegetal.2018, author = {Edip, K. and Sesov, V. and Butenweg, Christoph and Bojadjieva, J.}, title = {Development of coupled numerical model for simulation of multiphase soil}, series = {Computers and Geotechnics}, volume = {96}, journal = {Computers and Geotechnics}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0266-352X}, doi = {10.1016/j.compgeo.2017.08.016}, pages = {118 -- 131}, year = {2018}, abstract = {In this paper, a coupled multiphase model considering both non-linearities of water retention curves and solid state modeling is proposed. The solid displacements and the pressures of both water and air phases are unknowns of the proposed model. The finite element method is used to solve the governing differential equations. The proposed method is demonstrated through simulation of seepage test and partially consolidation problem. Then, implementation of the model is done by using hypoplasticity for the solid phase and analyzing the fully saturated triaxial experiments. In integration of the constitutive law error controlling is improved and comparisons done accordingly. In this work, the advantages and limitations of the numerical model are discussed.}, language = {en} } @article{ZhangValeroBungetal.2018, author = {Zhang, G. and Valero, Daniel and Bung, Daniel Bernhard and Chanson, H.}, title = {On the estimation of free-surface turbulence using ultrasonic sensors}, series = {Flow Measurement and Instrumentation}, volume = {60}, journal = {Flow Measurement and Instrumentation}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0955-5986}, doi = {10.1016/j.flowmeasinst.2018.02.009}, pages = {171 -- 184}, year = {2018}, abstract = {Accurate determination of free-surface dynamics has attracted much research attention during the past decade and has important applications in many environmental and water related areas. In this study, the free-surface dynamics in several turbulent flows commonly found in nature were investigated using a synchronised setup consisting of an ultrasonic sensor and a high-speed video camera. Basic sensor capabilities were examined in dry conditions to allow for a better characterisation of the present sensor model. The ultrasonic sensor was found to adequately reproduce free-surface dynamics up to the second order, especially in two-dimensional scenarios with the most energetic modes in the low frequency range. The sensor frequency response was satisfactory in the sub-20 Hz band, and its signal quality may be further improved by low-pass filtering prior to digitisation. The application of the USS to characterise entrapped air in high-velocity flows is also discussed.}, language = {en} }