@book{Laack2007, author = {Laack, Walter van}, title = {To perceive the world with logic}, publisher = {van Laack}, address = {Aachen}, isbn = {978-3-936624-08-3}, pages = {340 S. : Ill., graph. Darst}, year = {2007}, language = {en} } @article{BaeckerKochEibenetal.2017, author = {B{\"a}cker, Matthias and Koch, Claudia and Eiben, Sabine and Geiger, Fania and Eber, Fabian and Gliemann, Hartmut and Poghossian, Arshak and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Tobacco mosaic virus as enzyme nanocarrier for electrochemical biosensors}, series = {Sensors and Actuators B: Chemical}, volume = {238}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.07.096}, pages = {716 -- 722}, year = {2017}, abstract = {The conjunction of (bio-)chemical recognition elements with nanoscale biological building blocks such as virus particles is considered as a very promising strategy for the creation of biohybrids opening novel opportunities for label-free biosensing. This work presents a new approach for the development of biosensors using tobacco mosaic virus (TMV) nanotubes or coat proteins (CPs) as enzyme nanocarriers. Sensor chips combining an array of Pt electrodes loaded with glucose oxidase (GOD)-modified TMV nanotubes or CP aggregates were used for amperometric detection of glucose as a model system for the first time. The presence of TMV nanotubes or CPs on the sensor surface allows binding of a high amount of precisely positioned enzymes without substantial loss of their activity, and may also ensure accessibility of their active centers for analyte molecules. Specific and efficient immobilization of streptavidin-conjugated GOD ([SA]-GOD) complexes on biotinylated TMV nanotubes or CPs was achieved via bioaffinity binding. These layouts were tested in parallel with glucose sensors with adsorptively immobilized [SA]-GOD, as well as [SA]-GOD crosslinked with glutardialdehyde, and came out to exhibit superior sensor performance. The achieved results underline a great potential of an integration of virus/biomolecule hybrids with electronic transducers for future applications in biosensorics and biochips.}, language = {en} } @article{HirschfeldLustfeldReisseletal.2010, author = {Hirschfeld, J. A. and Lustfeld, H. and Reißel, Martin and Steffen, B.}, title = {Tomographic diagnostics of current distributions in a fuel cell stack}, series = {International Journal of Energy Research}, volume = {34}, journal = {International Journal of Energy Research}, number = {3}, isbn = {0363-907X}, pages = {284 -- 292}, year = {2010}, language = {en} } @inproceedings{EllerwegRitz2008, author = {Ellerweg, Roland and Ritz, Thomas}, title = {Tool supported requirements analysis for the user centered development of mobile enterprise software}, series = {Proceeding of Wireless Applications and Computing 2008 and Telecommunications, Networks and Systems 2008 : MCCSIS '08 ; IADIS Multi Conference on Computer Science and Information Systems ; 22 - 24 July 2008, Amsterdam, The Netherlands}, booktitle = {Proceeding of Wireless Applications and Computing 2008 and Telecommunications, Networks and Systems 2008 : MCCSIS '08 ; IADIS Multi Conference on Computer Science and Information Systems ; 22 - 24 July 2008, Amsterdam, The Netherlands}, editor = {Roth, J{\"o}rg}, publisher = {IADIS Press}, address = {[Lisboa]}, isbn = {978-972-8924-62-1}, pages = {160 -- 162}, year = {2008}, abstract = {A user centered development method has proved satisfactory for the development of mobile enterprise software. To make use of this method, detailed information about the user and the place where the user interacts with his mobile device is required. This article describes how both can be modeled by a stereotypical and conceptual extended UML extension. Finally, a software tool is presented that supports the developed UML extension.}, language = {en} } @article{FischerKowalskiPudasaini2012, author = {Fischer, Jan-Thomas and Kowalski, Julia and Pudasaini, Shiva P.}, title = {Topographic curvature effects in applied avalanche modelling}, series = {Cold Regions Science and Technology}, volume = {74-75}, journal = {Cold Regions Science and Technology}, publisher = {Elsevier}, address = {Amsterdam}, issn = {1872-7441}, doi = {10.1016/j.coldregions.2012.01.005}, pages = {21 -- 30}, year = {2012}, abstract = {This paper describes the implementation of topographic curvature effects within the RApid Mass MovementS (RAMMS) snow avalanche simulation toolbox. RAMMS is based on a model similar to shallow water equations with a Coulomb friction relation and the velocity dependent Voellmy drag. It is used for snow avalanche risk assessment in Switzerland. The snow avalanche simulation relies on back calculation of observed avalanches. The calibration of the friction parameters depends on characteristics of the avalanche track. The topographic curvature terms are not yet included in the above mentioned classical model. Here, we fundamentally improve this model by mathematically and physically including the topographic curvature effects. By decomposing the velocity dependent friction into a topography dependent term that accounts for a curvature enhancement in the Coulomb friction, and a topography independent contribution similar to the classical Voellmy drag, we construct a general curvature dependent frictional resistance, and thus propose new extended model equations. With three site-specific examples, we compare the apparent frictional resistance of the new approach, which includes topographic curvature effects, to the classical one. Our simulation results demonstrate substantial effects of the curvature on the flow dynamics e.g., the dynamic pressure distribution along the slope. The comparison of resistance coefficients between the two models demonstrates that the physically based extension presents an improvement to the classical approach. Furthermore a practical example highlights its influence on the pressure outline in the run out zone of the avalanche. Snow avalanche dynamics modeling natural terrain curvature centrifugal force friction coefficients.}, language = {en} } @inproceedings{SchaenzleAltherrEdereretal.2015, author = {Sch{\"a}nzle, Christian and Altherr, Lena and Ederer, Thorsten and Pelz, Peter}, title = {TOR - Towards the energetically optimal ventilation system}, pages = {1 Seite}, year = {2015}, language = {en} } @inproceedings{PenneProfittlichRingbecketal.2010, author = {Penne, Jochen and Profittlich, Martin and Ringbeck, Thorsten and Buxbaum, Bernd}, title = {Touchless detailed 3D scan of human hand anatomy using time-of-flight cameras}, series = {Proceedings of the International Conference on 3D Body Scanning Technologies : Lugano, Switzerland, 19-20 October 2010}, booktitle = {Proceedings of the International Conference on 3D Body Scanning Technologies : Lugano, Switzerland, 19-20 October 2010}, editor = {D, Nicola D'Apuzzo}, publisher = {Hometrica Consulting}, address = {Z{\"u}rich}, isbn = {978-3-033-02714-5}, pages = {361 -- 369}, year = {2010}, language = {en} } @article{RoehlenPilasDahmenetal.2018, author = {R{\"o}hlen, Desiree and Pilas, Johanna and Dahmen, Markus and Keusgen, Michael and Selmer, Thorsten and Sch{\"o}ning, Michael Josef}, title = {Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes}, series = {Frontiers in Chemistry}, journal = {Frontiers in Chemistry}, number = {6}, publisher = {Frontiers}, address = {Lausanne}, doi = {10.3389/fchem.2018.00284}, pages = {Artikel 284}, year = {2018}, abstract = {Monitoring of organic acids (OA) and volatile fatty acids (VFA) is crucial for the control of anaerobic digestion. In case of unstable process conditions, an accumulation of these intermediates occurs. In the present work, two different enzyme-based biosensor arrays are combined and presented for facile electrochemical determination of several process-relevant analytes. Each biosensor utilizes a platinum sensor chip (14 × 14 mm²) with five individual working electrodes. The OA biosensor enables simultaneous measurement of ethanol, formate, d- and l-lactate, based on a bi-enzymatic detection principle. The second VFA biosensor provides an amperometric platform for quantification of acetate and propionate, mediated by oxidation of hydrogen peroxide. The cross-sensitivity of both biosensors toward potential interferents, typically present in fermentation samples, was investigated. The potential for practical application in complex media was successfully demonstrated in spiked sludge samples collected from three different biogas plants. Thereby, the results obtained by both of the biosensors were in good agreement to the applied reference measurements by photometry and gas chromatography, respectively. The proposed hybrid biosensor system was also used for long-term monitoring of a lab-scale biogas reactor (0.01 m³) for a period of 2 months. In combination with typically monitored parameters, such as gas quality, pH and FOS/TAC (volatile organic acids/total anorganic carbonate), the amperometric measurements of OA and VFA concentration could enhance the understanding of ongoing fermentation processes.}, language = {en} } @article{ArreolaKeusgenSchoening2019, author = {Arreola, Julio and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Toward an immobilization method for spore-based biosensors in oxidative environment}, series = {Electrochimica Acta}, volume = {302}, journal = {Electrochimica Acta}, publisher = {Elsevier}, address = {Amsterdam}, doi = {10.1016/j.electacta.2019.01.148}, pages = {394 -- 401}, year = {2019}, language = {en} } @article{TakenagaBiselliSchnitzleretal.2014, author = {Takenaga, Shoko and Biselli, Manfred and Schnitzler, Thomas and {\"O}hlschl{\"a}ger, Peter and Wagner, Torsten and Sch{\"o}ning, Michael Josef}, title = {Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis-Menten-like kinetics for cell culturing}, series = {Physica status solidi A : Applications and materials science}, volume = {211}, journal = {Physica status solidi A : Applications and materials science}, number = {6}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)}, doi = {10.1002/pssa.201330464}, pages = {1410 -- 1415}, year = {2014}, abstract = {The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17-200 mM) follows a Michaelis-Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.}, language = {en} } @article{OberlaenderBrommWendeleretal.2015, author = {Oberl{\"a}nder, Jan and Bromm, Alexander and Wendeler, Luisa and Iken, Heiko and Palomar Duran, Marlena and Greeff, Anton and Kirchner, Patrick and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a biosensor to monitor the sterilisation efficiency of aseptic filling machines}, series = {Physica status solidi (a)}, volume = {212}, journal = {Physica status solidi (a)}, number = {6}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201431900}, pages = {1299 -- 1305}, year = {2015}, abstract = {Sterilisation processes are compulsory in medicine, pharmacy, and food industries to prevent infections of consumers and microbiological contaminations of products. Monitoring the sterilisation by conventional microbiological methods is time- and lab-consuming. To overcome this problem, in this work a novel biosensor has been proposed. The sensor enables a fast method to evaluate sterilisation processes. By means of thin-film technology the sensor's transducer structures in form of IDEs (interdigitated electrodes) have been fabricated on a silicon substrate. Physical characterisation of the developed sensor was done by AFM, SEM, and profilometry. Impedance analyses were conducted for the electrical characterisation. As microbiological layer spores of B. atrophaeus have been immobilised on the sensing structure; spores of this type are a well-known sterilisation test organism. Impedance measurements at a fixed frequency over time were performed to monitor the immobilisation process. A sterilisation process according to aseptic filling machines was applied to demonstrate the sensor functionality. After both, immobilisation and sterilisation, a change in impedance could successfully be detected.}, language = {en} } @article{SchoeningArzdorfMulchandanietal.2003, author = {Sch{\"o}ning, Michael Josef and Arzdorf, M. and Mulchandani, P. and Chen, W. and Mulchandani, A.}, title = {Towards a capacitive enzyme sensor for direct determination of organophosphorus pesticides: Fundamentals studies and aspects of development}, series = {Sensors. 3 (2003), H. 6}, journal = {Sensors. 3 (2003), H. 6}, isbn = {1424-8220}, pages = {119 -- 127}, year = {2003}, language = {en} } @inproceedings{GoemmelButenwegKob2005, author = {G{\"o}mmel, Andreas and Butenweg, Christoph and Kob, Malte}, title = {Towards a complete finite-element model of human phonation: modeling phonatory maneuvers}, series = {12th Workshop on the Finite Element Method in Biomedical Engineering, Biomechanics and Related Fields : Ulm, Germany, 20 - 21 July 2005 / University of Ulm, Department of Orthodontics ...}, booktitle = {12th Workshop on the Finite Element Method in Biomedical Engineering, Biomechanics and Related Fields : Ulm, Germany, 20 - 21 July 2005 / University of Ulm, Department of Orthodontics ...}, publisher = {Univ., Dep. of Orthodontics}, address = {Ulm}, organization = {Workshop on the Finite Element Method in Biomedical Engineering, Biomechanics and Related Fields <12, 2005, Ulm>}, isbn = {978-3-9806183-8-0}, pages = {1 CD-ROM}, year = {2005}, language = {en} } @inproceedings{BeckerEggertWinkelmannetal.2011, author = {Becker, J{\"o}rg and Eggert, Mathias and Winkelmann, Axel and Knackstedt, Ralf}, title = {Towards a Contingency Theory based Model of the Influence of Regulation on MIS}, series = {Proceedings of the Seventeenth Americas Conference on Information Systems, Detroit, Michigan August 4th -7 th 2011}, booktitle = {Proceedings of the Seventeenth Americas Conference on Information Systems, Detroit, Michigan August 4th -7 th 2011}, year = {2011}, language = {en} } @inproceedings{ChircuCzarneckiFriedmannetal.2023, author = {Chircu, Alina and Czarnecki, Christian and Friedmann, Daniel and Pomaskow, Johanna and Sultanow, Eldar}, title = {Towards a Digital Twin of Society}, series = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023}, booktitle = {Proceedings of the 56th Hawaii International Conference on System Sciences 2023}, publisher = {University of Hawai'i}, address = {Honolulu}, isbn = {978-0-9981331-6-4}, pages = {6748 -- 6757}, year = {2023}, abstract = {This paper describes the potential for developing a digital twin of society- a dynamic model that can be used to observe, analyze, and predict the evolution of various societal aspects. Such a digital twin can help governmental agencies and policy makers in interpreting trends, understanding challenges, and making decisions regarding investments or policies necessary to support societal development and ensure future prosperity. The paper reviews related work regarding the digital twin paradigm and its applications. The paper presents a motivating case study- an analysis of opportunities and challenges faced by the German federal employment agency, Bundesagentur f¨ur Arbeit (BA), proposes solutions using digital twins, and describes initial proofs of concept for such solutions.}, language = {en} } @article{MolinnusDrinicIkenetal.2021, author = {Molinnus, Denise and Drinic, Aleksander and Iken, Heiko and Kr{\"o}ger, Nadja and Zinser, Max and Smeets, Ralf and K{\"o}pf, Marius and Kopp, Alexander and Sch{\"o}ning, Michael Josef}, title = {Towards a flexible electrochemical biosensor fabricated from biocompatible Bombyx mori silk}, series = {Biosensors and Bioelectronics}, volume = {183}, journal = {Biosensors and Bioelectronics}, number = {Art. 113204}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0956-5663}, doi = {10.1016/j.bios.2021.113204}, year = {2021}, language = {en} } @article{FerreinDyllaLakemeyeretal.2005, author = {Ferrein, Alexander and Dylla, Frank and Lakemeyer, Gerhard and Murray, Jan}, title = {Towards a League-Independent Qualitative Soccer Theory for RoboCup / Dylla, Frank ; Ferrein, Alexander ; Lakemeyer, Gerhard ; Murray, Jan ; Obst, Oliver ; R{\"o}fer, Thomas ; Stolzenburg, Frieder ; Visser, Ubbo}, series = {RoboCup 2004: Robot Soccer World Cup VIII / Daniele Nardi ... (ed.).}, journal = {RoboCup 2004: Robot Soccer World Cup VIII / Daniele Nardi ... (ed.).}, publisher = {Springer}, address = {Berlin}, isbn = {978-3-540-25046-8}, pages = {611 -- 618}, year = {2005}, language = {en} } @inproceedings{EichenbaumNikolovskiMuelhensetal.2023, author = {Eichenbaum, Julian and Nikolovski, Gjorgji and M{\"u}lhens, Leon and Reke, Michael and Ferrein, Alexander and Scholl, Ingrid}, title = {Towards a lifelong mapping approach using Lanelet 2 for autonomous open-pit mine operations}, series = {2023 IEEE 19th International Conference on Automation Science and Engineering (CASE)}, booktitle = {2023 IEEE 19th International Conference on Automation Science and Engineering (CASE)}, publisher = {IEEE}, isbn = {979-8-3503-2069-5 (Online)}, doi = {10.1109/CASE56687.2023.10260526}, pages = {8 Seiten}, year = {2023}, abstract = {Autonomous agents require rich environment models for fulfilling their missions. High-definition maps are a well-established map format which allows for representing semantic information besides the usual geometric information of the environment. These are, for instance, road shapes, road markings, traffic signs or barriers. The geometric resolution of HD maps can be as precise as of centimetre level. In this paper, we report on our approach of using HD maps as a map representation for autonomous load-haul-dump vehicles in open-pit mining operations. As the mine undergoes constant change, we also need to constantly update the map. Therefore, we follow a lifelong mapping approach for updating the HD maps based on camera-based object detection and GPS data. We show our mapping algorithm based on the Lanelet 2 map format and show our integration with the navigation stack of the Robot Operating System. We present experimental results on our lifelong mapping approach from a real open-pit mine.}, language = {en} } @inproceedings{NeumannFerreinKallweitetal.2014, author = {Neumann, Tobias and Ferrein, Alexander and Kallweit, Stephan and Scholl, Ingrid}, title = {Towards a mobile mapping robot for underground mines}, series = {7th Conference of Robotics and Mechatronics : RobMech 2014 : 27th and 28th Nov. 2014, Cape Town}, booktitle = {7th Conference of Robotics and Mechatronics : RobMech 2014 : 27th and 28th Nov. 2014, Cape Town}, organization = {Conference of Robotics and Mechatronics <7, 2014, Cape Town, South Africa>}, pages = {1 -- 6}, year = {2014}, language = {en} } @article{MolinnusBegingLowisetal.2020, author = {Molinnus, Denise and Beging, Stefan and Lowis, Carsten and Sch{\"o}ning, Michael Josef}, title = {Towards a multi-enzyme capacitive field-effect biosensor by comparative study of drop-coating and nano-spotting technique}, series = {Sensors}, volume = {20}, journal = {Sensors}, number = {17}, publisher = {MDPI}, address = {Basel}, isbn = {1424-8220}, doi = {10.3390/s20174924}, pages = {Artikel 4942}, year = {2020}, abstract = {Multi-enzyme immobilization onto a capacitive field-effect biosensor by nano-spotting technique is presented. The nano-spotting technique allows to immobilize different enzymes simultaneously on the sensor surface with high spatial resolution without additional photolithographical patterning. The amount of applied enzymatic cocktail on the sensor surface can be tailored. Capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors with Ta2O5 as pH-sensitive transducer layer have been chosen to immobilize the three different (pL droplets) enzymes penicillinase, urease, and glucose oxidase. Nano-spotting immobilization is compared to conventional drop-coating method by defining different geometrical layouts on the sensor surface (fully, half-, and quarter-spotted). The drop diameter is varying between 84 µm and 102 µm, depending on the number of applied drops (1 to 4) per spot. For multi-analyte detection, penicillinase and urease are simultaneously nano-spotted on the EIS sensor. Sensor characterization was performed by C/V (capacitance/voltage) and ConCap (constant capacitance) measurements. Average penicillin, glucose, and urea sensitivities for the spotted enzymes were 81.7 mV/dec, 40.5 mV/dec, and 68.9 mV/dec, respectively.}, language = {en} } @article{ReisertGeisslerFloerkeetal.2011, author = {Reisert, Steffen and Geissler, Hanno and Fl{\"o}rke, Rudolf and N{\"a}ther, Niko and Wagner, Patrick and Sch{\"o}ning, Michael Josef}, title = {Towards a multi-sensor system for the evaluation of aseptic processes employing hydrogen peroxide vapour (H2O2)}, series = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, journal = {Physica status solidi (a) : applications and material science. 208 (2011), H. 6}, publisher = {Wiley}, address = {Weinheim}, isbn = {1862-6319}, pages = {1351 -- 1356}, year = {2011}, language = {en} } @inproceedings{BohrnStuetzFleischeretal.2012, author = {Bohrn, U. and St{\"u}tz, E. and Fleischer, M. and Sch{\"o}ning, Michael Josef and Wagner, P.}, title = {Towards a paradigm change - mammalian cells as sensitive biosensor layers for the detection of unexpected toxic substances in air}, series = {Nanoscale Science and Technology (NS\&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012}, booktitle = {Nanoscale Science and Technology (NS\&T´12) : Proceedings Book Humboldt Kolleg ; Tunisia, 17-19 March, 2012}, editor = {Abdelghani, Adnane and Sch{\"o}ning, Michael Josef}, pages = {44 -- 44}, year = {2012}, language = {en} } @article{GerhardsSkorupaSanderetal.2011, author = {Gerhards, M. and Skorupa, S. and Sander, Volker and Pfeiffer, P. and Belloum, A.}, title = {Towards a security framework for a WS-HumanTask processor}, series = {7th International Conference on Network and Service Management (CNSM), 2011 Paris}, journal = {7th International Conference on Network and Service Management (CNSM), 2011 Paris}, publisher = {IEEE}, address = {New York}, isbn = {978-3-901882-44-9}, pages = {1 -- 5}, year = {2011}, language = {en} } @article{KirchnerOberlaenderSusoetal.2013, author = {Kirchner, Patrick and Oberl{\"a}nder, Jan and Suso, Henri-Pierre and Rysstad, Gunnar and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards a wireless sensor system for real-time H2O2 monitoring in aseptic food processes}, series = {Physica status solidi (a)}, volume = {210}, journal = {Physica status solidi (a)}, number = {5}, publisher = {Wiley}, address = {Weinheim}, issn = {1862-6319}, doi = {10.1002/pssa.201200920}, pages = {877 -- 883}, year = {2013}, abstract = {A wireless sensor system based on the industrial ZigBee standard for low-rate wireless networking was developed that enables real-time monitoring of gaseous H2O2 during the package sterilization in aseptic food processes. The sensor system consists of a remote unit connected to a calorimetric gas sensor, which was already established in former works, and an external base unit connected to a laptop computer. The remote unit was built up by an XBee radio frequency (RF) module for data communication and a programmable system-on-chip controller to read out the sensor signal and process the sensor data, whereas the base unit is a second XBee RF module. For the rapid H2O2 detection on various locations inside the package that has to be sterilized, a novel read-out strategy of the calorimetric gas sensor was established, wherein the sensor response is measured within the short sterilization time and correlated with the present H2O2 concentration. In an exemplary measurement application in an aseptic filling machinery, the suitability of the new, wireless sensor system was demonstrated, wherein the influence of the gas velocity on the H2O2 distribution inside a package was determined and verified with microbiological tests.}, language = {en} } @article{PoghossianWernerBuniatyanetal.2017, author = {Poghossian, Arshak and Werner, Frederik and Buniatyan, V. V. and Wagner, Torsten and Miamoto, K. and Yoshinobu, T. and Sch{\"o}ning, Michael Josef}, title = {Towards addressability of light-addressable potentiometric sensors: Shunting effect of non-illuminated region and cross-talk}, series = {Sensor and Actuators B: Chemical}, journal = {Sensor and Actuators B: Chemical}, number = {244}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.01.047}, pages = {1071 -- 1079}, year = {2017}, abstract = {The LAPS (light-addressable potentiometric sensor) platform is one of the most attractive approaches for chemical and biological sensing with many applications ranging from pH and ion/analyte concentration measurements up to cell metabolism detection and chemical imaging. However, although it is generally accepted that LAPS measurements are spatially resolved, the light-addressability feature of LAPS devices has not been discussed in detail so far. In this work, an extended electrical equivalent-circuit model of the LAPS has been presented, which takes into account possible cross-talk effects due to the capacitive coupling of the non-illuminated region. A shunting effect of the non-illuminated area on the measured photocurrent and addressability of LAPS devices has been studied. It has been shown, that the measured photocurrent will be determined not only by the local interfacial potential in the illuminated region but also by possible interfacial potential changes in the non-illuminated region, yielding cross-talk effects. These findings were supported by the experimental investigations of a penicillin-sensitive multi-spot LAPS and a metal-insulator-semiconductor LAPS as model systems.}, language = {en} } @article{BerretzSkorupaSanderetal.2010, author = {Berretz, F. and Skorupa, S. and Sander, Volker and Belloum, A.}, title = {Towards an actor-driven workflow management system for grids}, series = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE}, journal = {International Symposium on Collaborative Technologies and Systems (CTS), 2010 : 17 - 21 May 2010, Chicago, Illinois, USA / IEEE}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {978-1-4244-6619-1}, pages = {611 -- 616}, year = {2010}, language = {en} } @article{MolinnusSorichBartzetal.2016, author = {Molinnus, Denise and Sorich, Maren and Bartz, Alexander and Siegert, Petra and Willenberg, Holger S. and Lisdat, Fred and Poghossian, Arshak and Keusgen, Michael and Sch{\"o}ning, Michael Josef}, title = {Towards an adrenaline biosensor based on substrate recycling amplification in combination with an enzyme logic gate}, series = {Sensors and Actuators B: Chemical}, volume = {237}, journal = {Sensors and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2016.06.064}, pages = {190 -- 195}, year = {2016}, abstract = {An amperometric biosensor using a substrate recycling principle was realized for the detection of low adrenaline concentrations (1 nM) by measurements in phosphate buffer and Ringer's solution at pH 6.5 and pH 7.4, respectively. In proof-of-concept experiments, a Boolean logic-gate principle has been applied to develop a digital adrenaline biosensor based on an enzyme AND logic gate. The obtained results demonstrate that the developed digital biosensor is capable for a rapid qualitative determination of the presence/absence of adrenaline in a YES/NO statement. Such digital biosensor could be used in clinical diagnostics for the control of a correct insertion of a catheter in the adrenal veins during adrenal venous-sampling procedure.}, language = {en} } @inproceedings{HuelsenMulsowDabrowskietal.2023, author = {H{\"u}lsen, Benjamin and Mulsow, Niklas A. and Dabrowski, Adam and Brinkmann, Wiebke and G{\"u}tzlaff, Joel and Spies, Leon and Czupalla, Markus and Kirchner, Frank}, title = {Towards an autonomous micro rover with night survivability for lunar exploration}, series = {Proceedings of the 74th International Astronautical Congress}, booktitle = {Proceedings of the 74th International Astronautical Congress}, publisher = {dfki}, pages = {12 Seiten}, year = {2023}, abstract = {In Europe, efforts are underway to develop key technologies that can be used to explore the Moon and to exploit the resources available. This includes technologies for in-situ resource utilization (ISRU), facilitating the possibility of a future Moon Village. The Moon is the next step for humans and robots to exploit the use of available resources for longer term missions, but also for further exploration of the solar system. A challenge for effective exploration missions is to achieve a compact and lightweight robot to reduce launch costs and open up the possibility of secondary payload options. Current micro rover concepts are primarily designed to last for one day of solar illumination and show a low level of autonomy. Extending the lifetime of the system by enabling survival of the lunar night and implementing a high level of autonomy will significantly increase potential mission applications and the operational range. As a reference mission, the deployment of a micro rover in the equatorial region of the Moon is being considered. An overview of mission parameters and a detailed example mission sequence is given in this paper. The mission parameters are based on an in-depth study of current space agency roadmaps, scientific goals, and upcoming flight opportunities. Furthermore, concepts of the ongoing international micro rover developments are analyzed along with technology solutions identified for survival of lunar nights and a high system autonomy. The results provide a basis of a concise requirements set-up to allow dedicated system developments and qualification measures in the future.}, language = {en} } @inproceedings{FerreinKallweitLautermann2012, author = {Ferrein, Alexander and Kallweit, Stephan and Lautermann, Mark}, title = {Towards an autonomous pilot system for a tunnel boring machine}, series = {5th Robotics and Mechatronics Conference of South Africa (ROBMECH) : 26 - 27 November 2012 ; CSIR International Conference Centre Gauteng South Africa}, booktitle = {5th Robotics and Mechatronics Conference of South Africa (ROBMECH) : 26 - 27 November 2012 ; CSIR International Conference Centre Gauteng South Africa}, publisher = {IEEE}, address = {Piscataway, NJ}, isbn = {978-1-4673-5183-6}, year = {2012}, language = {en} } @article{Ferrein2008, author = {Ferrein, Alexander}, title = {Towards applying soccer moves in the RoboCup Standard Platform League}, series = {{\"O}GAI-Journal}, volume = {Bd. 27}, journal = {{\"O}GAI-Journal}, number = {H. 3}, organization = {{\"O}sterreichische Gesellschaft f{\"u}r Artificial Intelligence}, issn = {0254-4326}, pages = {4 -- 9}, year = {2008}, language = {en} } @article{VargaDavinsonGloriusetal.2020, author = {Varga, Laszlo and Davinson, Thomas and Glorius, Jan and Jurado, Beatrix and Langer, Christoph and Lederer-Woods, Claudia and Litvinov, Yuri A. and Reifarth, Rene and Slavkovska, Zuzana and St{\"o}hlker, Thomas and Woods, Phil J. and Xing, Yuan Ming}, title = {Towards background-free studies of capture reaction in a heavy-ion storage ring}, series = {Journal of Physics: Conference Series}, volume = {1668}, journal = {Journal of Physics: Conference Series}, number = {Art 012046}, publisher = {IOP}, address = {Bristol}, year = {2020}, abstract = {Stored and cooled, highly-charged ions offer unprecedented capabilities for precision studies in the realm of atomic, nuclear structure and astrophysics[1]. After the successful investigation of the 96Ru(p,7)97Rh reaction cross section in 2009[2], the first measurement of the 124Xe(p,7)125Cs reaction cross section has been performed with decelerated, fully-ionized 124Xe ions in 2016 at the Experimental Storage Ring (ESR) of GSI[3]. Using a Double Sided Silicon Strip Detector, introduced directly into the ultra-high vacuum environment of a storage ring, the 125Cs proton-capture products have been successfully detected. The cross section has been measured at 5 different energies between 5.5AMeV and 8AMeV, on the high energy tail of the Gamow-window for hot, explosive scenarios such as supernovae and X-ray binaries. The elastic scattering on the H2 gas jet target is the major source of background to count the (p,7) events. Monte Carlo simulations show that an additional slit system in the ESR in combination with the energy information of the Si detector will enable background free measurements of the proton-capture products. The corresponding hardware is being prepared and will increase the sensitivity of the method tremendously.}, language = {en} } @inproceedings{NiemuellerEwertReuteretal.2013, author = {Niem{\"u}ller, Tim and Ewert, Daniel and Reuter, Sebastian and Karras, Ulrich and Ferrein, Alexander}, title = {Towards benchmarking cyber-physical systems in factory automation scenarios}, series = {KI 2013: advances in artificial intelligence : 36th Annual German Conference on AI, Koblenz, Germany, September 16-20, 2013 ; proceedings / Ingo J. Timm ... (ed.). (Lecture notes in computer science ; 8077)}, booktitle = {KI 2013: advances in artificial intelligence : 36th Annual German Conference on AI, Koblenz, Germany, September 16-20, 2013 ; proceedings / Ingo J. Timm ... (ed.). (Lecture notes in computer science ; 8077)}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-40941-7}, pages = {296 -- 299}, year = {2013}, language = {en} } @article{JacobsGrobKethers1994, author = {Jacobs, Stephan and Grob, Robert and Kethers, Stefanie}, title = {Towards CIS in Quality Management - Integration of Agents and Methods / Robert Grob, Stephan Jacobs, Stefanie Kethers}, series = {Proceedings of the Second International Conference on Cooperative Information Systems : May 17 - 20, 1994, Toronto, Canada / sponsored by the University of Toronto. Editors: Michael Brodie}, journal = {Proceedings of the Second International Conference on Cooperative Information Systems : May 17 - 20, 1994, Toronto, Canada / sponsored by the University of Toronto. Editors: Michael Brodie}, publisher = {University of Toronto Press}, address = {Toronto}, year = {1994}, language = {en} } @inproceedings{SerrorHenzeHacketal.2018, author = {Serror, Martin and Henze, Martin and Hack, Sacha and Schuba, Marko and Wehrle, Klaus}, title = {Towards in-network security for smart homes}, series = {13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018}, booktitle = {13th International Conference on Availability, Reliability and Security, ARES 2018; Hamburg; Germany; 27 August 2018 through 30 August 2018}, isbn = {978-145036448-5}, doi = {10.1145/3230833.3232802}, pages = {Article numer 3232802}, year = {2018}, language = {en} } @inproceedings{PfaffSchmidtEnning2017, author = {Pfaff, Raphael and Schmidt, B. D. and Enning, Manfred}, title = {Towards inclusion of the freight rail system in the industrial internet of things - Wagon 4.0}, series = {Stephenson Conference, London, March 2017}, booktitle = {Stephenson Conference, London, March 2017}, pages = {1 -- 10}, year = {2017}, language = {en} } @article{BooysenRiegerFerrein2011, author = {Booysen, Tracy and Rieger, Michael and Ferrein, Alexander}, title = {Towards inexpensive robots for science \& technology teaching and education in Africa}, publisher = {IEEE}, address = {New York}, isbn = {978-1-61284-992-8}, pages = {1 -- 6}, year = {2011}, language = {en} } @inproceedings{Jacobs2007, author = {Jacobs, Stephan}, title = {Towards integration driven design : experience report}, series = {Software Engineering 2007 : Beitr{\"a}ge zu den Workshops ; Fachtagung des GI-Fachbereichs Softwaretechnik ; 27. - 30.03.2007 in Hamburg. - (GI-Edition : Proceedings ; 106)}, booktitle = {Software Engineering 2007 : Beitr{\"a}ge zu den Workshops ; Fachtagung des GI-Fachbereichs Softwaretechnik ; 27. - 30.03.2007 in Hamburg. - (GI-Edition : Proceedings ; 106)}, editor = {Bleek, Wolf-Gideon}, publisher = {Ges. f{\"u}r Informatik}, address = {Bonn}, isbn = {978-3-88579-200-0}, pages = {143 -- 150}, year = {2007}, language = {en} } @article{SchoeningAbouzarIngebrandtetal.2006, author = {Sch{\"o}ning, Michael Josef and Abouzar, Maryam H. and Ingebrandt, Sven and Platen, Johannes and Offenh{\"a}usser, Andreas and Poghossian, Arshak}, title = {Towards label-free detection of charged macromolecules using field-effect-based structures : Scaling down from capacitive EIS sensor over ISFET to nano-scale devices}, series = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, journal = {Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A.}, number = {paper 0915-R05-04}, editor = {Comini, Elisabetta}, isbn = {9781558998711}, pages = {89 -- 94}, year = {2006}, language = {en} } @article{BreuerPilasGuthmannetal.2019, author = {Breuer, Lars and Pilas, Johanna and Guthmann, Eric and Sch{\"o}ning, Michael Josef and Thoelen, Ronald and Wagner, Torsten}, title = {Towards light-addressable flow control: responsive hydrogels with incorporated graphene oxide as laser-driven actuator structures within microfluidic channels}, series = {Sensor and Actuators B: Chemical}, volume = {288}, journal = {Sensor and Actuators B: Chemical}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2019.02.086}, pages = {579 -- 585}, year = {2019}, language = {en} } @article{WeldenPoghossianVahidpouretal.2022, author = {Welden, Melanie and Poghossian, Arshak and Vahidpour, Farnoosh and Wendlandt, Tim and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers}, series = {Biosensors}, volume = {12}, journal = {Biosensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios12010043}, pages = {Artikel 43}, year = {2022}, abstract = {Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1-3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.}, language = {en} } @incollection{PriedeFerrein2013, author = {Priede, Gareth and Ferrein, Alexander}, title = {Towards passive walking for the fully-actuated biped robot Nao}, series = {Emerging trends in computing, informatics, systems sciences, and engineering. (Lecture notes in electrical engineering : vol. 151)}, booktitle = {Emerging trends in computing, informatics, systems sciences, and engineering. (Lecture notes in electrical engineering : vol. 151)}, publisher = {Springer}, address = {New York, NY}, isbn = {978-1-4614-3557-0 ; 978-1-4614-3558-7}, doi = {10.1007/978-1-4614-3558-7_18}, pages = {225 -- 236}, year = {2013}, abstract = {Many biped robots deploy a form of gait that follows the zero moment point (ZMP) approach, that is, the robot is in a stable position at any point in time. This requires the robot to be fully actuated. While very stable, the draw-backs of this approach are a fairly slow gait and high energy consumption. An alternative approach is the so-called passive-dynamic walking, where the gait makes use of the inertia and dynamic stability of the robot. In this paper we describe our ongoing work of combining the principles of passive-dynamic walking on the fully-actuated biped robot Nao, which is also deployed for robotic soccer applications. We present a simple controller that allows the robot to stably rock sidewards, showing a closed limit-cycle. We discuss first results of superimposing a forward motion on the sidewards motion. Based on this we expect to endow the Nao with a fast, robust, and stable passive-dynamic walk on the fully-actuated Nao in the future.}, language = {en} } @incollection{FrotscherStaat2018, author = {Frotscher, Ralf and Staat, Manfred}, title = {Towards Patient-Specific Computational Modeling of hiPS-Derived Cardiomyocyte Function and Drug Action}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_10}, pages = {233 -- 250}, year = {2018}, abstract = {Human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) today are widely used for the investigation of normal electromechanical cardiac function, of cardiac medication and of mutations. Computational models are thus established that simulate the behavior of this kind of cells. This section first motivates the modeling of hiPS-CM and then presents and discusses several modeling approaches of microscopic and macroscopic constituents of human-induced pluripotent stem cell-derived and mature human cardiac tissue. The focus is led on the mapping of the computational results one can achieve with these models onto mature human cardiomyocyte models, the latter being the real matter of interest. Model adaptivity is the key feature that is discussed because it opens the way for modeling various biological effects like biological variability, medication, mutation and phenotypical expression. We compare the computational with experimental results with respect to normal cardiac function and with respect to inotropic and chronotropic drug effects. The section closes with a discussion on the status quo of the specificity of computational models and on what challenges have to be solved to reach patient-specificity.}, language = {en} } @article{KramerValeroChansonetal.2019, author = {Kramer, Matthias and Valero, Daniel and Chanson, Hubert and Bung, Daniel Bernhard}, title = {Towards reliable turbulence estimations with phase-detection probes: an adaptive window cross-correlation technique}, series = {Experiments in Fluids}, volume = {60}, journal = {Experiments in Fluids}, publisher = {Springer}, address = {Berlin}, issn = {1432-1114}, doi = {10.1007/s00348-018-2650-9}, year = {2019}, language = {en} } @article{PoghossianPlatenSchoening2005, author = {Poghossian, Arshak and Platen, J. and Sch{\"o}ning, Michael Josef}, title = {Towards self-aligned nanostructures by means of layerexpansion technique}, series = {Electrochimica Acta. 51 (2005), H. 5}, journal = {Electrochimica Acta. 51 (2005), H. 5}, isbn = {0013-4686}, pages = {838 -- 843}, year = {2005}, language = {en} } @article{BehbahaniBehrNicolaietal.2008, author = {Behbahani, Mehdi and Behr, Marek and Nicolai, Mike and Probst, Markus}, title = {Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM}, series = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)}, journal = {NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum J{\"u}lich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot M{\"u}nster; Dietrich Wolf; Manfred Kremer (ed.)}, publisher = {Forschungszentrum}, address = {J{\"u}lich}, isbn = {978-3-9810843-5-1}, pages = {325 -- 332}, year = {2008}, language = {en} } @inproceedings{LuepfertHerrmannPriceetal.2004, author = {L{\"u}pfert, E. and Herrmann, Ulf and Price, Henry and Zarza, E. and Kistener, R.}, title = {Towards Standard Performance Analysis for Parabolic Trough Collector Fields}, series = {12th International Symposium Solar Power and Chemical Energy Systems, October 6-8, 2004, Oaxaca Mexico ; SolarPACES International Symposium, 12}, booktitle = {12th International Symposium Solar Power and Chemical Energy Systems, October 6-8, 2004, Oaxaca Mexico ; SolarPACES International Symposium, 12}, editor = {Ramos, C.}, publisher = {Instituto de Investigaciones Electricas}, address = {[s.l.]}, isbn = {968-6114-18-1}, year = {2004}, language = {en} } @misc{WaicziesKuehneWinteretal.2013, author = {Waiczies, Helmar and K{\"u}hne, Andr{\´e} and Winter, Lukas and Frauenrath, Tobias and Hoffmann, Werner and Ittermann, Bernd and Waiczies, Sonia and Niendorf, Thoralf}, title = {Towards theranostics of rheumatoid arthritis: 1H/19F imaging of non-steroidal anti-inflammatory drugs in hand and wrist at 7 Tesla}, series = {2013 ISMRM Annual Meeting Proceedings}, journal = {2013 ISMRM Annual Meeting Proceedings}, issn = {1545-4428}, year = {2013}, abstract = {We have developed a double-tuned ¹H/¹⁹F birdcage resonator dedicated for hand and wrist imaging at 7 T to locally image non-steroidal anti-inflammatory drugs (NSAID) such as 2-{[3-(Trifluoromethyl) phenyl]amino}benzoic acid. The preliminary in vivo images acquired by the double-tuned ¹H/¹⁹F birdcage resonator demonstrate the feasibility for ¹H/¹⁹F hand- and wrist-imaging at 7 T. While the diagnostic quality of the coil needs to be assessed in patients with inflammatory rheumatoid disease, first ¹⁹F images of the NSAID are encouraging, and point towards the prospect of applying ¹⁹F-MRI to visualize and quantify the concentration of therapeutically-active compound at the sites of inflammation.}, language = {en} } @inproceedings{BurgethKleefeldZhangetal.2022, author = {Burgeth, Bernhard and Kleefeld, Andreas and Zhang, Eugene and Zhang, Yue}, title = {Towards Topological Analysis of Non-symmetric Tensor Fields via Complexification}, series = {Discrete Geometry and Mathematical Morphology}, booktitle = {Discrete Geometry and Mathematical Morphology}, editor = {Baudrier, {\´E}tienne and Naegel, Beno{\^i}t and Kr{\"a}henb{\"u}hl, Adrien and Tajine, Mohamed}, publisher = {Springer}, address = {Cham}, isbn = {978-3-031-19897-7}, doi = {10.1007/978-3-031-19897-7_5}, pages = {48 -- 59}, year = {2022}, abstract = {Fields of asymmetric tensors play an important role in many applications such as medical imaging (diffusion tensor magnetic resonance imaging), physics, and civil engineering (for example Cauchy-Green-deformation tensor, strain tensor with local rotations, etc.). However, such asymmetric tensors are usually symmetrized and then further processed. Using this procedure results in a loss of information. A new method for the processing of asymmetric tensor fields is proposed restricting our attention to tensors of second-order given by a 2x2 array or matrix with real entries. This is achieved by a transformation resulting in Hermitian matrices that have an eigendecomposition similar to symmetric matrices. With this new idea numerical results for real-world data arising from a deformation of an object by external forces are given. It is shown that the asymmetric part indeed contains valuable information.}, language = {en} } @inproceedings{FredebeulKrein2016, author = {Fredebeul-Krein, Markus}, title = {Towards trade facilitation via regulatory convergence: An analysis of the TTIP chapter on Electronic Communications}, series = {Regional ITS Conference of the International Telecommunications Society. Cambridge, United Kingdom, 7-9 September 2016}, booktitle = {Regional ITS Conference of the International Telecommunications Society. Cambridge, United Kingdom, 7-9 September 2016}, pages = {29 Seiten}, year = {2016}, abstract = {To give the exchange of goods and services between the European Union (EU) and the United States (U.S.) new momentum the two parties are currently negotiating the transatlantic free trade agreement Transatlantic Trade and Investment Partnership (TTIP). The aim is to create the largest free trade area in the world. The agreement, once entered into force, will oblige EU countries and the U.S. to further liberalize their markets. The negotiations on TTIP include a chapter on Electronic Communications/ Telecommunications. The challenge therein will be securing commitments for market access to Electronic Communications services. At the same time, these commitments must reflect the legitimate need for consumer protection issues. The need to reduce Electronic Communications-related non-tariff barriers to trade between the Parties is due to the fact that these markets are heavily regulated. Without transnational rules as to regulations national governments can abuse these regulations to deter the market entry by new (foreign) suppliers. Thus the free trade agreement TTIP affects in many respects regulatory provisions on and access to Electronic Communications markets. The objective of this paper is therefore to examine to what extend the regulatory principles for Electronic Communications markets envisaged under TTIP will result in trade facilitation and regulatory convergence between the EU and the U.S. As to this question the result of the analysis is that the chapter on Electronic Communications will be an important step towards facilitating trade in Electronic Communications services. At the same time some regulatory convergence will take place, but this convergence will not lead to a (full) harmonization of regulations. Rather the norm, also after TTIP negotiations will have been concluded successfully, will be mutual recognition of different regulatory regimes. Different regulations being the optimal policy response in different market settings will continue to exist. Moreover, it is very unlikely that such regulatory principles for the Electronic Communications sector are a vehicle for a race to the bottom in levels of consumer protection.}, language = {en} } @article{RaabKappelKraemeretal.2011, author = {Raab, Monika and Kappel, Sven and Kr{\"a}mer, Andrea and Sanhaji, Mourad and Matthess, Yves and Kurunci-Csacsko, Elisabeth and Calzada-Wack, Julia and Rathkolb, Birgit and Rosman, Jan and Adler, Thure and Busch, Dirk H. and Esposito, Irene and Fuchs, Helmut and Gailus-Durner, Val{\´e}rie and Klingenspor, Martin and Wolf, Eckhard and S{\"a}nger, Nicole and Prinz, Florian and Hrabe de Angelis, Martin and Seibler, Jost and Yuan, Juping and Bergmann, Martin and Knecht, Rainald and Kreft, Bertolt and Strebhardt, Klaus}, title = {Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells}, series = {Nature Communications}, volume = {2}, journal = {Nature Communications}, number = {395}, publisher = {Nature}, address = {London}, issn = {2041-1723}, doi = {10.1038/ncomms1395}, pages = {1 -- 11}, year = {2011}, language = {en} }