@incollection{DachwaldBoehnhardtBrojetal.2014, author = {Dachwald, Bernd and Boehnhardt, Herrmann and Broj, Ulrich and Geppert, Ulrich R. M. E. and Grundmann, Jan-Thimo and Seboldt, Wolfgang and Seefeldt, Patric and Spietz, Peter and Johnson, Les and K{\"u}hrt, Ekkehard and Mottola, Stefano and Macdonald, Malcolm and McInnes, Colin R. and Vasile, Massimiliano and Reinhard, Ruedeger}, title = {Gossamer roadmap technology reference study for a multiple NEO Rendezvous Mission}, series = {Advances in solar sailing}, booktitle = {Advances in solar sailing}, publisher = {Springer}, address = {Berlin [u.a.]}, isbn = {978-3-642-34906-5 (Print) ; 978-3-642-34907-2 (E-Book)}, pages = {211 -- 226}, year = {2014}, abstract = {A technology reference study for a multiple near-Earth object (NEO) rendezvous mission with solar sailcraft is currently carried out by the authors of this paper. The investigated mission builds on previous concepts, but adopts a strong micro-spacecraft philosophy based on the DLR/ESA Gossamer technology. The main scientific objective of the mission is to explore the diversity of NEOs. After direct interplanetary insertion, the solar sailcraft should—within less than 10 years—rendezvous three NEOs that are not only scientifically interesting, but also from the point of human spaceight and planetary defense. In this paper, the objectives of the study are outlined and a preliminary potential mission profile is presented.}, language = {en} } @article{LaackLeversStaat2013, author = {Laack, Walter van and Levers, A. and Staat, Manfred}, title = {Gonarthrosetherapie auf Kernspinresonanzbasis mit MBST-Vierjahresbeobachtungen}, series = {Orthop{\"a}dische Nachrichten : Zeitung f{\"u}r Orthop{\"a}die und Unfallchirurgie. 2013, H. 7/8}, journal = {Orthop{\"a}dische Nachrichten : Zeitung f{\"u}r Orthop{\"a}die und Unfallchirurgie. 2013, H. 7/8}, publisher = {Biermann}, address = {K{\"o}ln}, issn = {1437-2193}, pages = {13}, year = {2013}, language = {de} } @inproceedings{Dachwald2005, author = {Dachwald, Bernd}, title = {Global optimization of low-thrust space missions using evolutionary neurocontrol}, series = {Proceedings of the international workshop on global optimization}, booktitle = {Proceedings of the international workshop on global optimization}, pages = {85 -- 90}, year = {2005}, abstract = {Low-thrust space propulsion systems enable flexible high-energy deep space missions, but the design and optimization of the interplanetary transfer trajectory is usually difficult. It involves much experience and expert knowledge because the convergence behavior of traditional local trajectory optimization methods depends strongly on an adequate initial guess. Within this extended abstract, evolutionary neurocontrol, a method that fuses artificial neural networks and evolutionary algorithms, is proposed as a smart global method for low-thrust trajectory optimization. It does not require an initial guess. The implementation of evolutionary neurocontrol is detailed and its performance is shown for an exemplary mission.}, language = {en} } @incollection{DachwaldOhndorf2019, author = {Dachwald, Bernd and Ohndorf, Andreas}, title = {Global optimization of continuous-thrust trajectories using evolutionary neurocontrol}, series = {Modeling and Optimization in Space Engineering}, booktitle = {Modeling and Optimization in Space Engineering}, publisher = {Springer}, address = {Cham}, isbn = {978-3-030-10501-3}, doi = {10.1007/978-3-030-10501-3_2}, pages = {33 -- 57}, year = {2019}, abstract = {Searching optimal continuous-thrust trajectories is usually a difficult and time-consuming task. The solution quality of traditional optimal-control methods depends strongly on an adequate initial guess because the solution is typically close to the initial guess, which may be far from the (unknown) global optimum. Evolutionary neurocontrol attacks continuous-thrust optimization problems from the perspective of artificial intelligence and machine learning, combining artificial neural networks and evolutionary algorithms. This chapter describes the method and shows some example results for single- and multi-phase continuous-thrust trajectory optimization problems to assess its performance. Evolutionary neurocontrol can explore the trajectory search space more exhaustively than a human expert can do with traditional optimal-control methods. Especially for difficult problems, it usually finds solutions that are closer to the global optimum. Another fundamental advantage is that continuous-thrust trajectories can be optimized without an initial guess and without expert supervision.}, language = {en} } @article{KurulganDemirciDemirciTrzewiketal.2011, author = {Kurulgan Demirci, Eylem and Demirci, T. and Trzewik, J{\"u}rgen and Linder, Peter and Karakulah, G. and Artmann, Gerhard and Sakizli, M. and Temiz Artmann, Ayseg{\"u}l}, title = {Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation}, series = {Cellular and molecular bioengineering. 4 (2011), H. 1}, journal = {Cellular and molecular bioengineering. 4 (2011), H. 1}, publisher = {Springer}, address = {Berlin}, isbn = {1865-5025}, pages = {46 -- 55}, year = {2011}, language = {en} } @article{DemirciKurulganDemirciTrzewiketal.2009, author = {Demirci, Taylan and Kurulgan Demirci, Eylem and Trzewik, J{\"u}rgen and Linder, Peter and Digel, Ilya and Artmann, Gerhard and Sakizli, Meral and Temiz Artmann, Ayseg{\"u}l}, title = {Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress}, series = {IUBMB Life. 61 (2009), H. 3}, journal = {IUBMB Life. 61 (2009), H. 3}, publisher = {Wiley-VCH}, address = {Weinheim}, isbn = {1521-6543}, pages = {311 -- 312}, year = {2009}, language = {en} } @article{RichterBraunsteinStaeudleetal.2021, author = {Richter, Charlotte and Braunstein, Bjoern and St{\"a}udle, Benjamin and Attias, Julia and Suess, Alexander and Weber, Tobias and Mileva, Katja N. and Rittweger, Joern and Green, David A. and Albracht, Kirsten}, title = {Gastrocnemius medialis contractile behavior is preserved during 30\% body weight supported gait training}, series = {Frontiers in Sports and Active Living}, volume = {2021}, journal = {Frontiers in Sports and Active Living}, number = {2}, publisher = {Frontiers}, address = {Lausanne}, issn = {2624-9367}, doi = {10.3389/fspor.2020.614559}, pages = {Artikel 614559}, year = {2021}, abstract = {Rehabilitative body weight supported gait training aims at restoring walking function as a key element in activities of daily living. Studies demonstrated reductions in muscle and joint forces, while kinematic gait patterns appear to be preserved with up to 30\% weight support. However, the influence of body weight support on muscle architecture, with respect to fascicle and series elastic element behavior is unknown, despite this having potential clinical implications for gait retraining. Eight males (31.9 ± 4.7 years) walked at 75\% of the speed at which they typically transition to running, with 0\% and 30\% body weight support on a lower-body positive pressure treadmill. Gastrocnemius medialis fascicle lengths and pennation angles were measured via ultrasonography. Additionally, joint kinematics were analyzed to determine gastrocnemius medialis muscle-tendon unit lengths, consisting of the muscle's contractile and series elastic elements. Series elastic element length was assessed using a muscle-tendon unit model. Depending on whether data were normally distributed, a paired t-test or Wilcoxon signed rank test was performed to determine if body weight supported walking had any effects on joint kinematics and fascicle-series elastic element behavior. Walking with 30\% body weight support had no statistically significant effect on joint kinematics and peak series elastic element length. Furthermore, at the time when peak series elastic element length was achieved, and on average across the entire stance phase, muscle-tendon unit length, fascicle length, pennation angle, and fascicle velocity were unchanged with respect to body weight support. In accordance with unchanged gait kinematics, preservation of fascicle-series elastic element behavior was observed during walking with 30\% body weight support, which suggests transferability of gait patterns to subsequent unsupported walking.}, language = {en} } @article{RichterBraunsteinStaeudleetal.2021, author = {Richter, Charlotte and Braunstein, Bj{\"o}rn and St{\"a}udle, Benjamin and Attias, Julia and S{\"u}ss, Alexander and Weber, Tobias and Mileva, Katya N. and Rittweger, J{\"o}rn and Green, David A. and Albracht, Kirsten}, title = {Gastrocnemius medialis contractile behavior during running differs between simulated Lunar and Martian gravities}, series = {Scientific reports}, volume = {11}, journal = {Scientific reports}, number = {Article number: 22555}, publisher = {Springer Nature}, address = {London}, issn = {2045-2322}, doi = {10.1038/s41598-021-00527-9}, pages = {13 Seiten}, year = {2021}, abstract = {The international partnership of space agencies has agreed to proceed forward to the Moon sustainably. Activities on the Lunar surface (0.16 g) will allow crewmembers to advance the exploration skills needed when expanding human presence to Mars (0.38 g). Whilst data from actual hypogravity activities are limited to the Apollo missions, simulation studies have indicated that ground reaction forces, mechanical work, muscle activation, and joint angles decrease with declining gravity level. However, these alterations in locomotion biomechanics do not necessarily scale to the gravity level, the reduction in gastrocnemius medialis activation even appears to level off around 0.2 g, while muscle activation pattern remains similar. Thus, it is difficult to predict whether gastrocnemius medialis contractile behavior during running on Moon will basically be the same as on Mars. Therefore, this study investigated lower limb joint kinematics and gastrocnemius medialis behavior during running at 1 g, simulated Martian gravity, and simulated Lunar gravity on the vertical treadmill facility. The results indicate that hypogravity-induced alterations in joint kinematics and contractile behavior still persist between simulated running on the Moon and Mars. This contrasts with the concept of a ceiling effect and should be carefully considered when evaluating exercise prescriptions and the transferability of locomotion practiced in Lunar gravity to Martian gravity.}, language = {en} } @article{DachwaldTuryshevDittusetal.2005, author = {Dachwald, Bernd and Turyshev, Slava G. and Dittus, H. and Shao, M. [u.a.]}, title = {Fundamental Physics with the Laser Astrometric Test Of Relativity / S.G. Turyshev ; H. Dittus ; M. Shao ... B.Dachwald ...}, series = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)}, journal = {Proceedings of the 39th ESLAB Symposium "Trends in Space Science and Cosmic Vision 2020" : 19 - 21 April 2005, ESTEC, Noordwijk, the Netherlands / European Space Agency. [Comp. by: F. Favata ...] . - (ESA SP ; 588)}, publisher = {ESA Publ. Div.}, address = {Noordwijk}, isbn = {9290928999}, pages = {8 -- 11}, year = {2005}, language = {en} } @incollection{AkimbekovZhanadilovnaUalievaetal.2020, author = {Akimbekov, Nuraly S. and Zhanadilovna, Abdieva G. and Ualieva, Perizat S. and Abaihanovna, Zhusipova D. and Digel, Ilya and Savitskaya, Irina S. and Zhubanova, Azhar Achmet}, title = {Functionalization of Carbon Based Wound Dressings with Antimicrobial Phytoextracts for Bioactive Treatment of Septic Wounds}, series = {Carbon Nanomaterials in Biomedicine and the Environment}, booktitle = {Carbon Nanomaterials in Biomedicine and the Environment}, publisher = {Jenny Stanford Publishing}, address = {Singapore}, isbn = {978-981-4800-27-3}, doi = {10.1201/9780429428647-11}, pages = {211 -- 228}, year = {2020}, abstract = {The treatment of septic wounds with curative dressings based on biocomposites containing sage and marigold phytoextracts was effective in in vitro and in vivo experiments. These dressings caused the purification of the wound surface from purulent-necrotic masses three days earlier than in the other experimental groups. The consequence of an increase in incidents of severe course of the wound and the observed tendency to increase the number of adverse effects is the development of long-term recurrent wound processes. To treat purulent wounds, the following tactics were used: The purulent wounds of animals were covered with the examined wound dressing, and then the next day samples were taken, the procedure was performed once in 2 days. To obtain the active nanostructured sorbents such as carbonized rice husks, they are functionalized with biologically active components possessing antimicrobial, anti-inflammatory, antitoxic, immunomodulating, antiallergic and other types of properties.}, language = {en} }