@article{SalpatiChuChenetal.2014, author = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja}, title = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins}, series = {Drug Metabolism and Disposition}, volume = {42}, journal = {Drug Metabolism and Disposition}, number = {8}, publisher = {ASPET}, address = {Bethesda, Md.}, issn = {1521-009X}, doi = {10.1124/dmd.114.057976}, pages = {1301 -- 1313}, year = {2014}, abstract = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.}, language = {en} } @article{WeldenPoghossianVahidpouretal.2022, author = {Welden, Melanie and Poghossian, Arshak and Vahidpour, Farnoosh and Wendlandt, Tim and Keusgen, Michael and Wege, Christina and Sch{\"o}ning, Michael Josef}, title = {Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers}, series = {Biosensors}, volume = {12}, journal = {Biosensors}, number = {1}, publisher = {MDPI}, address = {Basel}, issn = {2079-6374}, doi = {10.3390/bios12010043}, pages = {Artikel 43}, year = {2022}, abstract = {Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1-3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate.}, language = {en} } @article{ClausnitzerKleefeld2024, author = {Clausnitzer, Julian and Kleefeld, Andreas}, title = {A spectral Galerkin exponential Euler time-stepping scheme for parabolic SPDEs on two-dimensional domains with a C² boundary}, series = {Discrete and Continuous Dynamical Systems - Series B}, volume = {29}, journal = {Discrete and Continuous Dynamical Systems - Series B}, number = {4}, publisher = {AIMS}, address = {Springfield}, issn = {1531-3492}, doi = {10.3934/dcdsb.2023148}, pages = {1624 -- 1651}, year = {2024}, abstract = {We consider the numerical approximation of second-order semi-linear parabolic stochastic partial differential equations interpreted in the mild sense which we solve on general two-dimensional domains with a C² boundary with homogeneous Dirichlet boundary conditions. The equations are driven by Gaussian additive noise, and several Lipschitz-like conditions are imposed on the nonlinear function. We discretize in space with a spectral Galerkin method and in time using an explicit Euler-like scheme. For irregular shapes, the necessary Dirichlet eigenvalues and eigenfunctions are obtained from a boundary integral equation method. This yields a nonlinear eigenvalue problem, which is discretized using a boundary element collocation method and is solved with the Beyn contour integral algorithm. We present an error analysis as well as numerical results on an exemplary asymmetric shape, and point out limitations of the approach.}, language = {en} } @inproceedings{BuxbaumSchwarteRingbeck1999, author = {Buxbaum, Bernd and Schwarte, Rudolf and Ringbeck, Thorsten}, title = {PMD-PLL: receiver structure for incoherent communication and ranging systems}, series = {Optical wireless communications II / [SPIE Conference on Optical Wireless Communications II], 22 September 1999, Boston, Massachusetts. - (SPIE proceedings series ; 3850)}, booktitle = {Optical wireless communications II / [SPIE Conference on Optical Wireless Communications II], 22 September 1999, Boston, Massachusetts. - (SPIE proceedings series ; 3850)}, editor = {Korevaar, Eric John}, publisher = {SPIE}, address = {Bellingham, Wash.}, isbn = {0-8194-3443-4}, issn = {0038-7355}, pages = {116 -- 130}, year = {1999}, language = {en} } @inproceedings{WallnoeferDrathHuening2015, author = {Walln{\"o}fer, Armin and Drath, Rainer and H{\"u}ning, Felix}, title = {Was ist Funktionales Engineering? Einordnung, Definition, Randbedingungen}, series = {Automation 2015 : 16. Branchentreff der Mess- und Automatisierungstechnik, 11. und 12. Juni 2015, Baden-Baden / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik}, booktitle = {Automation 2015 : 16. Branchentreff der Mess- und Automatisierungstechnik, 11. und 12. Juni 2015, Baden-Baden / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik}, publisher = {VDI-Verl.}, address = {D{\"u}sseldorf}, isbn = {978-3-18-092258-4}, pages = {1 CD-ROM}, year = {2015}, language = {de} } @article{AbdelLatifPeekenBenner1985, author = {Abdel-Latif, Lotfie Ahmed and Peeken, Heinz and Benner, Joachim}, title = {Термогидродинамический расчет упорных подшипников с круговыми подушками на масляной пленке, содержащей пузырьки газа}, series = {Проблемы трения и смазки}, volume = {107}, journal = {Проблемы трения и смазки}, number = {4}, pages = {94 -- 102}, year = {1985}, language = {ru} } @book{Vieth2008, author = {Vieth, Matthias}, title = {Geld-zur{\"u}ck-Garantien: Eine empirische Wirkungsanalyse aus Konsumentensicht.}, publisher = {Springer Gabler}, address = {Wiesbaden}, isbn = {978-3-8349-1408-8}, pages = {217 Seiten}, year = {2008}, language = {de} } @inproceedings{FingerBraunBil2018, author = {Finger, Felix and Braun, Carsten and Bil, Cees}, title = {Case studies in initial sizing for hybrid-electric general aviation aircraft}, series = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio}, booktitle = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio}, doi = {10.2514/6.2018-5005}, year = {2018}, language = {en} } @misc{TippkoetterRothMoehringetal.2014, author = {Tippk{\"o}tter, Nils and Roth, J. and M{\"o}hring, M. and Wulfhorst, H. and Ulber, Roland}, title = {Verwertung von Bioraffinerie-Stoffstr{\"o}men am Beispiel von Einzellerproteinen}, series = {Chemie Ingenieur Technik}, volume = {86}, journal = {Chemie Ingenieur Technik}, number = {9}, publisher = {Wiley-VCH}, address = {Weinheim}, issn = {0009-286X}, doi = {10.1002/cite.201450257}, pages = {1399 -- 1400}, year = {2014}, abstract = {Die Nutzung von Biomasse aus pflanzlichen Abf{\"a}llen f{\"u}r die stoffliche Verwertung r{\"u}ckt immer st{\"a}rker in den Vordergrund. Dabei ist vor allem die ganzheitliche Verwertung der Stoffstr{\"o}me von Bedeutung, da diese einen integrativen Ansatz erm{\"o}glichen. Im Rahmen dieser Arbeit wird die Produktion von Einzellerproteinen (Single-Cell Proteins, SCPs) mithilfe von unterschiedlichen Rohsubstraten dargelegt. Somit k{\"o}nnen Reststoffstr{\"o}me, die in keiner Konkurrenz zur Produktion von Lebensmitteln stehen, f{\"u}r die Herstellung von Futter- und auch Nahrungsmitteln Verwendung finden. Die zun{\"a}chst thermisch vorbehandelten Ausgangsmaterialien stammen aus forstwirtschaftlichen und gr{\"u}nen Abf{\"a}llen und erm{\"o}glichen durch eine anschließende enzymatische Hydrolyse die Freisetzung von Monosacchariden. Aus diesen erfolgt die SCP-Produktion fermentativ mithilfe der drei Modellorganismen Bakterium, Hefe und Pilz. Hierf{\"u}r wird sowohl das fl{\"u}ssige Hydrolysat als auch der feste Reststoff auf der Basis einer Feststofffermentation genutzt. Auf diese Weise ist eine vollst{\"a}ndige Verwertung der Ausgangsmaterialien m{\"o}glich. Mit den gewonnen Daten erfolgt abschließend eine Bewertung der SCPs aus nachwachsenden Rohstoffen als alternative Proteinquelle.}, language = {de} } @inproceedings{SchopenShabaniEschetal.2022, author = {Schopen, Oliver and Shabani, Bahman and Esch, Thomas and Kemper, Hans and Shah, Neel}, title = {Quantitative evaluation of health management designs for fuel cell systems in transport vehicles}, series = {2nd UNITED-SAIG International Conference Proceedings}, booktitle = {2nd UNITED-SAIG International Conference Proceedings}, editor = {Rahim, S.A. and As'arry, A. and Zuhri, M.Y.M. and Harmin, M.Y. and Rezali, K.A.M. and Hairuddin, A.A.}, pages = {1 -- 3}, year = {2022}, abstract = {Focusing on transport vehicles, mainly with regard to aviation applications, this paper presents compilation and subsequent quantitative evaluation of methods aimed at building an optimum integrated health management solution for fuel cell systems. The methods are divided into two different main types and compiled in a related scheme. Furthermore, different methods are analysed and evaluated based on parameters specific to the aviation context of this study. Finally, the most suitable method for use in fuel cell health management systems is identified and its performance and suitability is quantified.}, language = {en} }