@inproceedings{PfaffSappler2014,
  author    = {Pfaff, Raphael and Sappler, Magnus},
  title     = {TRANSPACT : die automatische Mittelpufferkupplung f{\"u}r attraktiven G{\"u}terverkehr},
  series = {RAIL-FREIGHT 2014 : Zukunft des Schieneng{\"u}terverkehrs ; Technologie - {\"O}konomie - {\"O}kologie - Verkehrspolitik ; [Tagungsdokumentation des IV. Internationalen Fachsymposiums zum Thema Schieneng{\"u}terverkehr] (Bahntechnik Aktuell ; 48)},
  booktitle = {RAIL-FREIGHT 2014 : Zukunft des Schieneng{\"u}terverkehrs ; Technologie - {\"O}konomie - {\"O}kologie - Verkehrspolitik ; [Tagungsdokumentation des IV. Internationalen Fachsymposiums zum Thema Schieneng{\"u}terverkehr] (Bahntechnik Aktuell ; 48)},
  publisher = {Verl. d. IFV Bahntechnik},
  address   = {Berlin},
  isbn      = {978-3-940727-41-1},
  pages     = {121 -- 128},
  year      = {2014},
  language  = {de}
}
@article{PhamStaat2014,
  author    = {Pham, Phu Tinh and Staat, Manfred},
  title     = {FEM-based shakedown analysis of hardening structures},
  series = {Asia Pacific journal on computational engineering},
  journal   = {Asia Pacific journal on computational engineering},
  number    = {1},
  publisher = {SpringerOpen},
  address   = {Berlin},
  issn      = {2196-1166 (E-Journal)},
  doi       = {10.1186/2196-1166-1-4},
  pages     = {Article No. 4},
  year      = {2014},
  abstract  = {This paper develops a new finite element method (FEM)-based upper bound algorithm for limit and shakedown analysis of hardening structures by a direct plasticity method. The hardening model is a simple two-surface model of plasticity with a fixed bounding surface. The initial yield surface can translate inside the bounding surface, and it is bounded by one of the two equivalent conditions: (1) it always stays inside the bounding surface or (2) its centre cannot move outside the back-stress surface. The algorithm gives an effective tool to analyze the problems with a very high number of degree of freedom. Our numerical results are very close to the analytical solutions and numerical solutions in literature.},
  language  = {en}
}
@inproceedings{PieperSchulz2014,
  author    = {Pieper, Martin and Schulz, Silvia},
  title     = {Teaching Simulation Methods with COMSOL Multiphysics},
  organization    = {COMSOL Conference <2014, Cambridge>},
  pages     = {7},
  year      = {2014},
  abstract  = {This paper describes two courses on simulation methods for graduate students: "Simulation Methods" and "Simulation and Optimization in Virtual Engineering" The courses were planned to teach young engineers how to work with simulation software as well as to understand the necessary mathematical background. As simulation software COMSOL is used. The main philosophy was to combine theory and praxis in a way that motivates the students. In addition "soft skills" should be improved. This was achieved by project work as final examination. As underlying didactical principle the ideas of Bloom's revised taxonomy were followed. The paper basically focusses on educational aspects, e.g. how to structure the course, plan the exercises, organize the project work and include practical COMSOL examples.},
  language  = {en}
}
@techreport{PisarczykRitzWallenborn2014,
  author    = {Pisarczyk, Rafael and Ritz, Thomas and Wallenborn, Ramona},
  title     = {Unterschiedliche Entwicklungsans{\"a}tze von Multiplattform-Anwendungen : Markt{\"u}bersicht},
  publisher = {eBusiness-Lotse},
  address   = {Aachen},
  pages     = {15 S. : Ill., graph. Darst.},
  year      = {2014},
  abstract  = {Die Markt{\"u}bersicht „Unterschiedliche Entwicklungsans{\"a}tze von Multiplattform-Anwendungen" richtet sich an IT-Dienstleister, Entwickler und IT-Abteilungen von Unternehmen, die Multiplattform Anwendungen entwickeln. In dieser Markt{\"u}bersicht werden verschiedene Entwicklungsans{\"a}tze beschrieben und ihre jeweiligen Vor- und Nachteile aufgezeigt.},
  language  = {de}
}
@article{PoghossianSchoening2014,
  author    = {Poghossian, Arshak and Sch{\"o}ning, Michael Josef},
  title     = {Label-free sensing of biomolecules with field-effect devices for clinical applications},
  series = {Electroanalysis},
  volume    = {26},
  journal   = {Electroanalysis},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-4109 (E-Journal); 1040-0397 (Print)},
  doi       = {10.1002/elan.201400073},
  pages     = {1197 -- 1213},
  year      = {2014},
  abstract  = {Among the variety of transducer concepts proposed for label-free detection of biomolecules, the semiconductor field-effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label-free, fast and real-time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point-of-care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label-free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody-antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.},
  language  = {en}
}
@incollection{PoghossianWeilandSchoening2014,
  author    = {Poghossian, Arshak and Weiland, Maryam and Sch{\"o}ning, Michael Josef},
  title     = {Nanoplate field-effect capacitors: a new transducer structure for multiparameter (bio-)chemical sensing},
  series = {Multisensor system for chemical analysis : materials and sensors},
  booktitle = {Multisensor system for chemical analysis : materials and sensors},
  editor    = {Lvova, Larisa and Kirsanov, Dmitry and di Natale, Corrado and Legin, Audrey},
  edition   = {1},
  publisher = {Jenny Stanford Publishing},
  address   = {Singapore},
  isbn      = {978-981-4411-15-8 ; 978-981-4411-16-5},
  doi       = {10.1201/b15491-11},
  pages     = {333 -- 373},
  year      = {2014},
  abstract  = {An array of electrically isolated nanoplate field-effect silicon-on-insulator (SOI) capacitors as a new transducer structure for multiparameter (bio-)chemical sensing is presented. The proposed approach allows addressable biasing and electrical readout of multiple nanoplate field-effect capacitive (bio-)chemical sensors on the same SOI chip, as well as differential-mode measurements. The realized sensor chip has been applied for pH and penicillin concentration measurements, electrical monitoring of polyelectrolyte multilayer formation, and the label-free electrical detection of consecutive deoxyribonucleic acid (DNA) hybridization and denaturation events.},
  language  = {en}
}
@article{PyschnyDoeringFeldmann2014,
  author    = {Pyschny, D. and D{\"o}ring, Bernd and Feldmann, M.},
  title     = {Ermittlung der thermischen Leistungsf{\"a}higkeit des neuartigen multifunktionalen Verbunddeckensystems InaDeck},
  series = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen},
  volume    = {89},
  journal   = {Bauingenieur : die richtungsweisende Zeitschrift im Bauingenieurswesen},
  number    = {3},
  publisher = {VDI Fachmedien},
  address   = {D{\"u}sseldorf},
  issn      = {0005-6650},
  pages     = {116 -- 124},
  year      = {2014},
  language  = {de}
}
@techreport{RahierRitzWallenborn2014,
  author    = {Rahier, Michael and Ritz, Thomas and Wallenborn, Ramona},
  title     = {Elektromobilit{\"a}t in einer vernetzten Welt : Potenziale f{\"u}r die IT-Branche bei der Organisation der Mobilit{\"a}t von morgen ; Info-Brosch{\"u}re},
  publisher = {eBusiness-Lotse},
  address   = {Aachen},
  pages     = {9 S. : Ill., graph. Darst.},
  year      = {2014},
  abstract  = {Die Informationsbrosch{\"u}re „Elektromobilit{\"a}t in einer vernetzten Welt" richtet sich an IT-Dienstleister. In dieser Brosch{\"u}re werden m{\"o}gliche Potenziale im Bereich der Elektromobilit{\"a}t aufgezeigt. Die Mobilit{\"a}t der Zukunft ist eine interdisziplin{\"a}re Angelegenheit und kein reines Automotive-Thema mehr. Beispiele wie Mobilit{\"a}tsmanagement, eCommerce und Individualisierung sind im Mobilit{\"a}tsbereich f{\"u}r die IT-Branche relevant.},
  language  = {de}
}
@article{RathMottaghy2014,
  author    = {Rath, V. and Mottaghy, Darius},
  title     = {Klimainformation aus dem Untergrund?},
  series = {Geographische Rundschau},
  volume    = {66},
  journal   = {Geographische Rundschau},
  number    = {7-8},
  publisher = {Westermann},
  address   = {Braunschweig},
  issn      = {0016-7460},
  pages     = {30 -- 36},
  year      = {2014},
  language  = {de}
}
@article{RatkeMilowLisinskietal.2014,
  author    = {Ratke, Lorenz and Milow, Barbara and Lisinski, Susanne and Hoepfner, Sandra},
  title     = {On an effect of fine ceramic particles on the structure of aerogels},
  series = {Microgravity science and technology},
  volume    = {26},
  journal   = {Microgravity science and technology},
  publisher = {Springer Nature},
  address   = {Heidelberg},
  issn      = {0938-0108 ; 1875-0494},
  doi       = {10.1007/s12217-014-9380-2},
  pages     = {103 -- 110},
  year      = {2014},
  language  = {en}
}
@article{RauAlexopoulosBreitbachetal.2014,
  author    = {Rau, Christoph and Alexopoulos, Spiros and Breitbach, Gerd and Hoffschmidt, Bernhard and Latzke, Markus and Sattler, Johannes, Christoph},
  title     = {Transient simulation of a solar-hybrid tower power plant with open volumetric receiver at the location Barstow},
  series = {Energy procedia : proceedings of the SolarPACES 2013 International Conference},
  volume    = {49},
  journal   = {Energy procedia : proceedings of the SolarPACES 2013 International Conference},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1876-6102},
  doi       = {10.1016/j.egypro.2014.03.157},
  pages     = {1481 -- 1490},
  year      = {2014},
  abstract  = {In this work the transient simulations of four hybrid solar tower power plant concepts with open-volumetric receiver technology for a location in Barstow-Daggett, USA, are presented. The open-volumetric receiver uses ambient air as heat transfer fluid and the hybridization is realized with a gas turbine. The Rankine cycle is heated by solar-heated air and/or by the gas turbine's flue gases. The plant can be operated in solar-only, hybrid parallel or combined cycle-only mode as well as in any intermediate load levels where the solar portion can vary between 0 to 100\%. The simulated plant is based on the configuration of a solar-hybrid power tower project, which is in planning for a site in Northern Algeria. The meteorological data for Barstow-Daggett was taken from the software meteonorm. The solar power tower simulation tool has been developed in the simulation environment MATLAB/Simulink and is validated.},
  language  = {en}
}
@article{RaueWambachGloeggleretal.2014,
  author    = {Raue, Markus and Wambach, M. and Gl{\"o}ggler, S. and Grefen, Dana and Kaufmann, R. and Abetz, C. and Georgopanos, P. and Handge, U. A. and Mang, Thomas and Bl{\"u}mich, B. and Abetz, V.},
  title     = {Investigation of historical hard rubber ornaments of Charles Goodyear},
  series = {Macromolecular chemistry and physics},
  volume    = {Vol. 215},
  journal   = {Macromolecular chemistry and physics},
  number    = {No. 3},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1022-1352},
  pages     = {245 -- 254},
  year      = {2014},
  language  = {en}
}
@incollection{Reichert2014,
  author    = {Reichert, Walter},
  title     = {Der Vertriebsingenieur: Ausbildung und Beruf},
  series = {Berufsstart Technik : das Karriereportal f{\"u}r junge Akademiker ; Ingenieure, Naturwissenschaftler, Informatiker},
  booktitle = {Berufsstart Technik : das Karriereportal f{\"u}r junge Akademiker ; Ingenieure, Naturwissenschaftler, Informatiker},
  publisher = {Resch},
  address   = {Großenkneten},
  pages     = {456 -- 458},
  year      = {2014},
  language  = {de}
}
@misc{ReyesOchoa2014,
  type      = {Master Thesis},
  author    = {Reyes Ochoa, Leonel},
  title     = {Engineering aspects of a parabolic trough collector field with direct steam generation and an organic rankine cycle},
  publisher = {Fachhochschule Aachen},
  address   = {Aachen},
  pages     = {X, 72 S.},
  year      = {2014},
  language  = {en}
}
@article{RiedelKartchemnikSchoeningetal.2014,
  author    = {Riedel, Marc and Kartchemnik, Julia and Sch{\"o}ning, Michael Josef and Lisdat, Fred},
  title     = {Impedimetric DNA detection - steps forward to sensorial application},
  series = {Analytical chemistry},
  volume    = {86 (2014)},
  journal   = {Analytical chemistry},
  number    = {15},
  publisher = {ACS Publications},
  address   = {Columbus},
  issn      = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)},
  doi       = {10.1021/ac501800q},
  pages     = {7867 -- 7874},
  year      = {2014},
  abstract  = {This study describes a label-free impedimetric sensor based on short ssDNA recognition elements for the detection of hybridization events. We concentrate on the elucidation of the influence of target length and recognition sequence position on the sensorial performance. The impedimetric measurements are performed in the presence of the redox system ferri-/ferrocyanide and show an increase in charge transfer resistance upon hybridization of ssDNA to the sensor surface. Investigations on the impedimetric signal stability demonstrate a clear influence of the buffers used during the sensor preparation and the choice of the passivating mercaptoalcanol compound. A stable sensor system has been developed, enabling a reproducible detection of 25mer target DNA in the low nanomolar range. After hybridization, a sensor regeneration can be reached with deionized water by adjustment of effective convection conditions, ensuring a sensor reusability. By investigations of longer targets with overhangs exposed to the solution, we can demonstrate applicability of the impedimetric detection for longer ssDNA. However, a decreasing charge transfer resistance change (ΔRct) is found by extending the overhang. As a strategy to increase the impedance change for longer target strands, the position of the recognition sequence can be designed in a way that a small overhang is exposed to the electrode surface. This is found to result in an increase in the relative Rct change. These results suggest that DNA and consequently negative charge near the electrode possess a larger impact on the impedimetric signal than DNA further away.},
  language  = {en}
}
@misc{Ritz2014,
  author    = {Ritz, Thomas},
  title     = {Multiplattformentwicklung f{\"u}r mobile Informationssysteme : eine strategische Perspektive},
  series = {Info-Veranstaltung Multiplattform-Entwicklung f{\"u}r mobile Anwendungen, Dezember 2013},
  journal   = {Info-Veranstaltung Multiplattform-Entwicklung f{\"u}r mobile Anwendungen, Dezember 2013},
  organization    = {FH Aachen, University of Applied Sciences / m2clab},
  pages     = {1 Video (Laufzeit: 23:57 Min.)},
  year      = {2014},
  language  = {de}
}
@misc{Ritz2014,
  author    = {Ritz, Thomas},
  title     = {Multiplattformentwicklung f{\"u}r mobile Informationssysteme : eine strategische Perspektive ; [Vortragsfolien]},
  series = {Info-Veranstaltung Multiplattform-Entwicklung f{\"u}r mobile Entwicklungen, Dezember 2013},
  journal   = {Info-Veranstaltung Multiplattform-Entwicklung f{\"u}r mobile Entwicklungen, Dezember 2013},
  organization    = {eBusinessLotse, Infob{\"u}ro f{\"u}r Unternehmen, Aachen},
  pages     = {13 S. : Ill., graph. Darst.},
  year      = {2014},
  language  = {de}
}
@inproceedings{RitzIzquierdoTelloDamm2014,
  author    = {Ritz, Thomas and Izquierdo Tello, C{\´e}sar and Damm, Sebastian},
  title     = {Connecting a pedelec to the cloud as basis for gamification in multi modal mobility planning},
  series = {MobileCloud 2014 : 2nd IEEE International Conference on Mobile Cloud Computing, Services, and Engineering Oxford, United Kingdom 7-10 April 2014},
  booktitle = {MobileCloud 2014 : 2nd IEEE International Conference on Mobile Cloud Computing, Services, and Engineering Oxford, United Kingdom 7-10 April 2014},
  publisher = {IEEE Service Center},
  address   = {Piscataway, NJ},
  isbn      = {978-1-4799-2504-9},
  doi       = {10.1109/MobileCloud.2014.25},
  pages     = {101 -- 108},
  year      = {2014},
  language  = {en}
}
@article{RitzPisarczykSachtlebenetal.2014,
  author    = {Ritz, Thomas and Pisarczyk, Rafael and Sachtleben, Johanna and Leßenich, Nina},
  title     = {Usability Engineering maßgeschneidert : Modellbaukasten zur Entwicklung gebrauchstauglicher mobiler Software},
  series = {Wissenschaft trifft Praxis},
  volume    = {1},
  journal   = {Wissenschaft trifft Praxis},
  number    = {1},
  publisher = {Begleitforschung Mittelstand-Digital c/o WIK-Consult GmbH},
  address   = {Bad Honnef},
  issn      = {2198-8544 (Print)},
  pages     = {79 -- 88},
  year      = {2014},
  language  = {de}
}
@techreport{RitzSiekmannWallenborn2014,
  author    = {Ritz, Thomas and Siekmann, Kirsten and Wallenborn, Ramona},
  title     = {Anforderungen an die Gestaltung multimodaler Mobilit{\"a}tsanwendungen : Potenziale f{\"u}r die IT-Branche bei der Organisation der verkehrsmittel{\"u}bergreifenden Mobilit{\"a}t von morgen am Beispiel CarSharing und privater PKW ; Info-Brosch{\"u}re},
  publisher = {eBusiness-Lotse},
  address   = {Aachen},
  pages     = {7 S. : Ill., graph. Darst.},
  year      = {2014},
  abstract  = {Die Informationsbrosch{\"u}re „Anforderungen an die Gestaltung multimodaler Mobilit{\"a}tsanwendungen" richtet sich an IT-Dienstleister. In dieser Brosch{\"u}re werden m{\"o}gliche Potenziale im Bereich des allgemeinen Mobilit{\"a}tsmanagements aufgezeigt. Automobilhersteller vernetzten sich zunehmend mit Technologie-Unternehmen. Es geht nicht nur um die besondere Entwicklung von spezieller Elektronik- und Softwarel{\"o}sungen f{\"u}r Navigations- und Entertainmentsysteme oder auch Fahrassistenz-Systemen in modernen PKW, sondern um einen {\"u}bergreifenden Design- und Interaktionsansatz f{\"u}r miteinander vernetzte Ger{\"a}te.},
  language  = {de}
}
@techreport{RitzSiekmannWallenborn2014,
  author    = {Ritz, Thomas and Siekmann, Kirsten and Wallenborn, Ramona},
  title     = {3D-Druck - Prozessmanagement f{\"u}r individualisierte Massenprodukte : Wie k{\"o}nnen Fertigungsdienstleister in die endkundengerichtete Produktion integriert werden? ; Info-Brosch{\"u}re},
  publisher = {eBusiness-Lotse},
  address   = {Aachen},
  pages     = {16 S. : Ill., graph. Darst.},
  year      = {2014},
  abstract  = {Die Informationsbrosch{\"u}re „3D-Druck - Prozessmanagement f{\"u}r individualisierte Massenprodukte" richtet sich an 3D-Druckdienstleister, die additive Fertigungsverfahren (Additive Manufacturing) nutzen, sowie an IT-Dienstleister, die eine Plattform f{\"u}r den Datenaustausch und die Individualisierung anbieten. Mit der additiven 3D-Drucktechnologie erfolgt die Fertigung von Produkten durch einen schichtweisen Aufbau. In dieser Brosch{\"u}re werden m{\"o}gliche Potenziale im Bereich der Herstellung mittels additiver Fertigungsverfahren aufgezeigt.},
  language  = {de}
}
@inproceedings{RosinButenweg2014,
  author    = {Rosin, Julia and Butenweg, Christoph},
  title     = {Berechnungsansatz f{\"u}r basisisolierte Tankbauwerke},
  series = {Berichte der Fachtagung Baustatik - Baupraxis 12 am 24. und 25. Februar 2014 an der Technischen Universit{\"a}t M{\"u}nchen / Hrsg. Kai-Uwe Bletzinger ...},
  booktitle = {Berichte der Fachtagung Baustatik - Baupraxis 12 am 24. und 25. Februar 2014 an der Technischen Universit{\"a}t M{\"u}nchen / Hrsg. Kai-Uwe Bletzinger ...},
  publisher = {Lehrstuhl f{\"u}r Statik, Techn. Univ. M{\"u}nchen},
  address   = {M{\"u}nchen},
  organization    = {Fachtagung Baustatik - Baupraxis <12, 2014, M{\"u}nchen>},
  isbn      = {978-3-00-041256-1},
  pages     = {103 -- 112},
  year      = {2014},
  language  = {de}
}
@inproceedings{RosinButenweg2014,
  author    = {Rosin, Julia and Butenweg, Christoph},
  title     = {Seismic isolation of cylindrical liquid storage tanks},
  series = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)},
  booktitle = {Proceedings of the 9th European Conference on Structural Dynamics, EURODYN 2014 Porto, Portugal, 30 June - 2 July 2014 / A. Cunha, E. Caetano, .... (eds.)},
  address   = {Porto},
  organization    = {European Conference on Structural Dynamics, EURODYN <9, 2014, Porto>},
  isbn      = {978-972-752-165-4},
  pages     = {3145 -- 3152},
  year      = {2014},
  language  = {en}
}
@inproceedings{RosinHenneboehlButenweg2014,
  author    = {Rosin, Julia and Henneb{\"o}hl, Benedickt and Butenweg, Christoph},
  title     = {Global buckling analysis of cylindrical liquid storage tanks under earthquake loading},
  series = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6},
  booktitle = {2nd European Conference on Earthquake Engineering and Seismology 2014 (2nd ECEES) : joint event of the 15th European Conference on Earthquake Engineering and the 34th General Assembly of the European Seismological Commission : Istanbul, Turkey, 25-29 August 2014 / European Association for Earthquake Engineering (EAEE) ; Vol. 6},
  publisher = {Curran Associates, Inc.},
  address   = {Red Hook, NY},
  organization    = {European Conference on Earthquake Engineering and Seismology <2, 2014, Istanbul>},
  isbn      = {978-1-5108-1021-1},
  pages     = {5270 -- 5281},
  year      = {2014},
  language  = {en}
}
@inproceedings{RosinKubalskiButenweg2014,
  author    = {Rosin, Julia and Kubalski, Thomas and Butenweg, Christoph},
  title     = {Seismic Design of cylindrical liquid storage tanks},
  series = {Seismic design of industrial facilities : proceedings of the International Conference on Seismic Design of Industrial Facilities (SeDIF-Conference) ; [Aachen, 26. - 27. September 2013] / Chair of Structural Statics and Dynamics, RWTH Aachen. Sven Klinkel ..., ed.},
  booktitle = {Seismic design of industrial facilities : proceedings of the International Conference on Seismic Design of Industrial Facilities (SeDIF-Conference) ; [Aachen, 26. - 27. September 2013] / Chair of Structural Statics and Dynamics, RWTH Aachen. Sven Klinkel ..., ed.},
  publisher = {Springer Vieweg},
  address   = {Wiesbaden},
  organization    = {International Conference on Seismic Design of Industrial Facilities <2013, Aachen>},
  isbn      = {978-3-658-02810-7 (E-Book) ; 978-3-658-02809-1 (Print)},
  doi       = {10.1007/978-3-658-02810-7_36},
  pages     = {429 -- 440},
  year      = {2014},
  language  = {en}
}
@inproceedings{RousseauKern2014,
  author    = {Rousseau, Alain and Kern, Alexander},
  title     = {How to deal with environmental risk in IEC 62305-2},
  series = {2014 International Conference on Lightning Protection (ICLP), Shanghai, China},
  booktitle = {2014 International Conference on Lightning Protection (ICLP), Shanghai, China},
  organization    = {International Conference on Lightning Protection <2014, Shanghai>},
  pages     = {521 -- 527},
  year      = {2014},
  abstract  = {The 2nd edition of the lightning risk management standard (IEC 62305-2) considers structures, which may endanger environment. In these cases, the loss is not limited to the structure itself, which is valid for usual structures. In the past (Edition 1) this danger was simply taken into account by a special hazard factor, multiplying the existing risk for the structure with a number. Now, in the edition 2, we add to the risk for the structure itself a "second risk" due to the losses outside the structure. The losses outside can be treated independently from what occurs inside. This is a major advantage to analyze the risk for sensitive structures, like chemical plants, nuclear plants, or structures containing explosives, etc. In this paper, the existing procedure given by the European version EN 62305-2 Ed.2 is further developed and applied to a few structures.},
  language  = {en}
}
@article{SalpatiChuChenetal.2014,
  author    = {Salpati, Laurent and Chu, Xiaoyan and Chen, Liangfu and Prasad, Bhagwat and Dallas, Shannon and Evers, Raymond and Mamaril-Fishman, Donna and Geier, Ethan G. and Kehler, Jonathan and Kunta, Jeevan and Mezler, Mario and Laplanche, Loic and Pang, Jodie and Soars, Matthew G. and Unadkat, Jashvant D. and van Waterschoot, Robert A.B. and Yabut, Jocelyn and Schinkel, Alfred H. and Scheer, Nico and Rode, Anja},
  title     = {Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {8},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057976},
  pages     = {1301 -- 1313},
  year      = {2014},
  abstract  = {Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse lines by evaluating the compensatory changes in mRNA expression, quantifying the amounts of OATP1B1 and -1B3 protein by liquid chromatography-tandem mass spectrometry, and studying the active uptake in isolated hepatocytes and the pharmacokinetics of some prototypical substrates including statins. Major outcomes from these studies were 1) mostly moderate compensatory changes in only a few genes involved in drug metabolism and disposition, 2) a robust hepatic expression of OATP1B1 and -1B3 proteins in the respective humanized mouse models, and 3) functional activities of the human transporters in hepatocytes isolated from the humanized models with several substrates tested in vitro and with pravastatin in vivo. However, the expression of OATP1B1 and -1B3 in the humanized models did not significantly alter liver or plasma concentrations of rosuvastatin and pitavastatin compared with Oatp1a/1b knockout controls under the conditions used in our studies. Hence, although the humanized OATP1B1 and -1B3 mice showed in vitro and/or in vivo functional activity with some statins, further characterization of these models is required to define their potential use and limitations in the prediction of drug disposition and drug-drug interactions in humans.},
  language  = {en}
}
@article{SawadaNakazawaTakenagaetal.2014,
  author    = {Sawada, Kazuaki and Nakazawa, Hirokazu and Takenaga, Shoko and Hizawa, Takeshi and Futagawa, Masato and Dasai, Fumihiro and Sakurai, Takashi and Okumura, Koichi and Hattori, Toshiaki and Ishida, Makoto},
  title     = {Multimodal bioimage sensor},
  series = {IEICE transactions on fundamentals of electronics, communidations and computer sciences},
  volume    = {E97-A (2014)},
  journal   = {IEICE transactions on fundamentals of electronics, communidations and computer sciences},
  number    = {3},
  publisher = {IEICE},
  address   = {Tokyo},
  issn      = {0916-8508 (Print) ; 1745-1337 (Online)},
  doi       = {10.1587/transfun.E97.A.726},
  pages     = {726 -- 733},
  year      = {2014},
  abstract  = {To visualize the biochemical distribution two-dimensionally, we invented a solid-state-type ion image sensor that indicates the chemical activity of solutions and cells. The device, which consists of a CCD array covered with a functionalized membrane to detect charge accumulation, is highly sensitive to changes in the concentration and two-dimensional distribution of ions and biomaterials.},
  language  = {en}
}
@article{ScheerMclaughlinRodeetal.2014,
  author    = {Scheer, Nico and Mclaughlin, Lesley A. and Rode, Anja and MacLeod, Alastair Kenneth and Henderson, Colin J. and Wolf, Roland C.},
  title     = {Deletion of thirty murine cytochrome P450 genes results in viable mice with compromised drug metabolism},
  series = {Drug Metabolism and Disposition},
  volume    = {42},
  journal   = {Drug Metabolism and Disposition},
  number    = {6},
  publisher = {ASPET},
  address   = {Bethesda, Md.},
  issn      = {1521-009X},
  doi       = {10.1124/dmd.114.057885},
  pages     = {1022 -- 1030},
  year      = {2014},
  abstract  = {In humans, 75\% of all drugs are metabolized by the cytochrome P450-dependent monooxygenase system. Enzymes encoded by the CYP2C, CYP2D, and CYP3A gene clusters account for ∼80\% of this activity. There are profound species differences in the multiplicity of cytochrome P450 enzymes, and the use of mouse models to predict pathways of drug metabolism is further complicated by overlapping substrate specificity between enzymes from different gene families. To establish the role of the hepatic and extrahepatic P450 system in drug and foreign chemical disposition, drug efficacy, and toxicity, we created a unique mouse model in which 30 cytochrome P450 genes from the Cyp2c, Cyp2d, and Cyp3a gene clusters have been deleted. Remarkably, despite a wide range of putative important endogenous functions, Cyp2c/2d/3a KO mice were viable and fertile, demonstrating that these genes have evolved primarily as detoxification enzymes. Although there was no overt phenotype, detailed examination showed Cyp2c/2d/3a KO mice had a smaller body size (15\%) and larger livers (20\%). Changes in hepatic morphology and a decreased blood glucose (30\%) were also noted. A five-drug cocktail of cytochrome P450 isozyme probe substrates were used to evaluate changes in drug pharmacokinetics; marked changes were observed in either the pharmacokinetics or metabolites formed from Cyp2c, Cyp2d, and Cyp3a substrates, whereas the metabolism of the Cyp1a substrate caffeine was unchanged. Thus, Cyp2c/2d/3a KO mice provide a powerful model to study the in vivo role of the P450 system in drug metabolism and efficacy, as well as in chemical toxicity.},
  language  = {en}
}
@article{ScheerWolf2014,
  author    = {Scheer, Nico and Wolf, C. Roland},
  title     = {Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications},
  series = {Xenobiotica},
  volume    = {44},
  journal   = {Xenobiotica},
  number    = {2},
  publisher = {Taylor \& Francis},
  address   = {Abingdon},
  issn      = {1366-5928},
  doi       = {10.3109/00498254.2013.815831},
  pages     = {96 -- 108},
  year      = {2014},
  abstract  = {1. Drug metabolizing enzymes and transporters play important roles in the absorption, metabolism, tissue distribution and excretion of various compounds and their metabolites and thus can significantly affect their efficacy and safety. Furthermore, they can be involved in drug-drug interactions which can result in adverse responses, life-threatening toxicity or impaired efficacy. Significant species differences in the interaction of compounds with drug metabolizing enzymes and transporters have been described. 2. In order to overcome the limitation of animal models in accurately predicting human responses, a large variety of mouse models humanized for drug metabolizing enzymes and to a lesser extent drug transporters have been created. 3. This review summarizes the literature describing these mouse models and their key applications in studying the role of drug metabolizing enzymes and transporters in drug bioavailability, tissue distribution, clearance and drug-drug interactions as well as in human metabolite testing and risk assessment. 4. Though such humanized mouse models have certain limitations, there is great potential for their use in basic research and for testing and development of new medicines. These limitations and future potentials will be discussed.},
  language  = {en}
}
@inproceedings{SchirraBauschatWatmuff2014,
  author    = {Schirra, Julian and Bauschat, J.-Michael and Watmuff, J.H.},
  title     = {Accurate induced drag prediction for highly non-planar lifting systems},
  series = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia},
  booktitle = {19th Australasian Fluid Mechanics Conference : 8.-11. Dezember 2014, Melbourne, Australia},
  pages     = {4 Seiten},
  year      = {2014},
  abstract  = {The impact of wake model effects is investigated for two highly non-planar lifting systems. Dependent on the geometrical arrangement of the configuration, the wake model shape is found to considerably affect the estimation. Particularly at higher angles of attack, an accurate estimation based on the common linear wake model approaches is involved.},
  language  = {en}
}
@inproceedings{SchirraWatmuffBauschat2014,
  author    = {Schirra, Julian and Watmuff, Jon and Bauschat, J.-Michael},
  title     = {A relative assessment of existing potential-methodologies to accurately estimate the induced drag of highly non-planar lifting systems},
  series = {Advanced aero concepts, design and operations : Applied Aerodynamics Conference : July 22 -24, 2014, Bristol, UK},
  booktitle = {Advanced aero concepts, design and operations : Applied Aerodynamics Conference : July 22 -24, 2014, Bristol, UK},
  organization    = {Applied Aerodynamics Conference <2014, Bristol>},
  pages     = {1 -- 13},
  year      = {2014},
  language  = {en}
}
@article{SchirraWatmuffBauschat2014,
  author    = {Schirra, Julian and Watmuff, Jonathan and Bauschat, J.-Michael},
  title     = {Highly non-planar lifting systems: a relative assessment of existing potential-methodologies to accurately estimate the induced drag},
  series = {32nd AIAA Applied Aerodynamics Conference 2014 : June, 16-20 2014, Atlanta, Ga.},
  journal   = {32nd AIAA Applied Aerodynamics Conference 2014 : June, 16-20 2014, Atlanta, Ga.},
  organization    = {American Institute of Aeronautics and Astronautics},
  isbn      = {978-1-62410-288-2},
  doi       = {10.2514/6.2014-2988},
  pages     = {Publ. online},
  year      = {2014},
  language  = {en}
}
@incollection{Schmidt2014,
  author    = {Schmidt, Herbert},
  title     = {Angst vor Zukunft, Lust auf Zukunft},
  series = {Re|peat-Jahrbuch Treasury und Private Banking : Produkte, M{\"a}rkte und Strategien zum Nachschlagen und Verstehen},
  booktitle = {Re|peat-Jahrbuch Treasury und Private Banking : Produkte, M{\"a}rkte und Strategien zum Nachschlagen und Verstehen},
  publisher = {Roland Eller},
  address   = {Potsdam},
  pages     = {255 -- 269},
  year      = {2014},
  language  = {de}
}
@book{SchneiderSchneider2014,
  author    = {Schneider, Bettina and Schneider, Wilhelm},
  title     = {Jahresabschluss und Jahresabschlussanalyse : systematische Darstellung in {\"U}bersichten. (Reihe Betriebswirtschaftslehre in {\"U}bersichten ; 2)},
  edition   = {5. Aufl., Studienausg.},
  publisher = {Cuvillier},
  address   = {G{\"o}ttingen},
  isbn      = {978-3-95404-828-1},
  pages     = {Getr. Z{\"a}hlung : graph. Darst.},
  year      = {2014},
  language  = {de}
}
@inproceedings{SchoppHeuermannHoltrup2014,
  author    = {Schopp, Christoph and Heuermann, Holger and Holtrup, S.},
  title     = {Investigation on efficacy optimization of RF-driven automotive D-lamps},
  series = {44th European Microwave Conference (EuMC),2014, Rome},
  booktitle = {44th European Microwave Conference (EuMC),2014, Rome},
  doi       = {10.1109/EuMC.2014.6986645},
  pages     = {1154 -- 1157},
  year      = {2014},
  language  = {en}
}
@inproceedings{SchreiberBarkschatKraft2014,
  author    = {Schreiber, Marc and Barkschat, Kai and Kraft, Bodo},
  title     = {Using Continuous Integration to organize and monitor the annotation process of domain specific corpora},
  series = {5th International Conference on Information and Communication Systems (ICICS) : 1-3 April 2014, Irbid, Jordanien},
  booktitle = {5th International Conference on Information and Communication Systems (ICICS) : 1-3 April 2014, Irbid, Jordanien},
  organization    = {International Conference on Information and Communication Systems <5, 2014, Irbid, Jordanien>},
  isbn      = {978-1-4799-3022-7},
  doi       = {10.1109/IACS.2014.6841958},
  pages     = {1 -- 6},
  year      = {2014},
  language  = {en}
}
@article{SchroeterHoffmannVoigtetal.2014,
  author    = {Schroeter, Rebecca and Hoffmann, Tamara and Voigt, Birgit and Meyer, Hanna and Bleisteiner, Monika and Muntel, Jan and J{\"u}rgen, Britta and Albrecht, Dirk and Becher, D{\"o}rte and Lalk, Michael and Evers, Stefan and Bongaerts, Johannes and Maurer, Karl-Heinz and Putzer, Harald and Hecker, Michael and Schweder, Thomas and Bremer, Erhard},
  title     = {Stress responses of the industrial workhorse Bacillus licheniformis to osmotic challenges},
  series = {PLoS ONE},
  volume    = {8},
  journal   = {PLoS ONE},
  number    = {11},
  publisher = {PLOS},
  address   = {San Francisco},
  issn      = {1932-6203},
  doi       = {10.1371/journal.pone.0080956},
  pages     = {e80956},
  year      = {2014},
  abstract  = {The Gram-positive endospore-forming bacterium Bacillus licheniformis can be found widely in nature and it is exploited in industrial processes for the manufacturing of antibiotics, specialty chemicals, and enzymes. Both in its varied natural habitats and in industrial settings, B. licheniformis cells will be exposed to increases in the external osmolarity, conditions that trigger water efflux, impair turgor, cause the cessation of growth, and negatively affect the productivity of cell factories in biotechnological processes. We have taken here both systems-wide and targeted physiological approaches to unravel the core of the osmostress responses of B. licheniformis. Cells were suddenly subjected to an osmotic upshift of considerable magnitude (with 1 M NaCl), and their transcriptional profile was then recorded in a time-resolved fashion on a genome-wide scale. A bioinformatics cluster analysis was used to group the osmotically up-regulated genes into categories that are functionally associated with the synthesis and import of osmostress-relieving compounds (compatible solutes), the SigB-controlled general stress response, and genes whose functional annotation suggests that salt stress triggers secondary oxidative stress responses in B. licheniformis. The data set focusing on the transcriptional profile of B. licheniformis was enriched by proteomics aimed at identifying those proteins that were accumulated by the cells through increased biosynthesis in response to osmotic stress. Furthermore, these global approaches were augmented by a set of experiments that addressed the synthesis of the compatible solutes proline and glycine betaine and assessed the growth-enhancing effects of various osmoprotectants. Combined, our data provide a blueprint of the cellular adjustment processes of B. licheniformis to both sudden and sustained osmotic stress.},
  language  = {en}
}
@book{SchulteZurhausen2014,
  author    = {Schulte-Zurhausen, Manfred},
  title     = {Organisation},
  edition   = {6., {\"u}berarb. und aktualisierte Aufl.},
  publisher = {Vahlen},
  address   = {M{\"u}nchen},
  isbn      = {978-3-8006-4689-0},
  pages     = {XVI, 687 S. : graph. Darst.},
  year      = {2014},
  language  = {de}
}
@article{SchusserBaeckerKrischeretal.2014,
  author    = {Schusser, Sebastian and B{\"a}cker, Matthias and Krischer, M. and Wenzel, L. and Leinhos, Marcel and Poghossian, Arshak and Biselli, Manfred and Wagner, P. and Sch{\"o}ning, Michael Josef},
  title     = {Enzymatically catalyzed degradation of biodegradable polymers investigated by means of a semiconductor-based field-effect sensor},
  series = {Procedia Engineering},
  volume    = {87},
  journal   = {Procedia Engineering},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1877-7058},
  doi       = {10.1016/j.proeng.2014.11.689},
  pages     = {1314 -- 1317},
  year      = {2014},
  abstract  = {A semiconductor field-effect device has been used for an enzymatically catalyzed degradation of biopolymers for the first time. This novel technique is capable to monitor the degradation process of multiple samples in situ and in real-time. As model system, the degradation of the biopolymer poly(D, L-lactic acid) has been monitored in the degradation medium containing the enzyme lipase from Rhizomucor miehei. The obtained results demonstrate the potential of capacitive field-effect sensors for degradation studies of biodegradable polymers.},
  language  = {en}
}
@incollection{SchoeningPoghossianGluecketal.2014,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Gl{\"u}ck, Olaf and Thust, Marion},
  title     = {Electrochemical composition measurement},
  series = {Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen},
  booktitle = {Measurement, instrumentation, and sensors handbook: electromagnetic, optical, radiation, chemical, and biomedical measuremen},
  edition   = {2nd ed.},
  publisher = {CRC Pr.},
  address   = {Boca Raton, Fa.},
  isbn      = {978-1-4398-4891-3},
  pages     = {55-1 -- 55-54},
  year      = {2014},
  language  = {en}
}
@incollection{SchoeningPoghossianGluecketal.2014,
  author    = {Sch{\"o}ning, Michael Josef and Poghossian, Arshak and Gl{\"u}ck, Olaf and Thust, Marion},
  title     = {Electrochemical methods for the determination of chemical variables in aqueous media},
  series = {Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement},
  booktitle = {Measurement, instrumentation, and sensors handbook / ed. by John G. Webster [u.a.] Vol. 2 : Electromagnetic, optical, radiation, chemical, and biomedical measurement},
  publisher = {CRC Pr.},
  address   = {Boca Raton, Fla.},
  isbn      = {978-1-4398-4891-3},
  pages     = {55-1 -- 55-54},
  year      = {2014},
  language  = {en}
}
@book{Siedenbiedel2014,
  author    = {Siedenbiedel, Georg},
  title     = {Corporate Compliance : Grundelemente der strukturellen Integration von Compliance-Konzepten},
  publisher = {NWB-Verl.},
  address   = {Herne},
  isbn      = {3-482-65131-0},
  pages     = {292 S.},
  year      = {2014},
  language  = {de}
}
@article{Sillius2014,
  author    = {Sillius, Sarah},
  title     = {„Viele machen gutes Marketing, ohne es zu wissen" : zwei Experten von FH [Prof. Dr. Gert Hoepner] und RWTH Aachen [Prof. Dr. Daniel Mentzel] erkl{\"a}ren, wie Unternehmen ihre Zielgruppe besser erreichen},
  series = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen},
  volume    = {2014},
  journal   = {Wirtschaftliche Nachrichten : das Magazin f{\"u}r Unternehmen / Industrie- und Handelskammer Aachen},
  number    = {3},
  publisher = {IHK Aachen},
  address   = {Aachen},
  pages     = {16 -- 18},
  year      = {2014},
  language  = {de}
}
@article{SiqueiraMolinnusBegingetal.2014,
  author    = {Siqueira, Jose R. and Molinnus, Denise and Beging, Stefan and Sch{\"o}ning, Michael Josef},
  title     = {Incorporating a hybrid urease-carbon nanotubes sensitive nanofilm on capacitive field-effect sensors for urea detection},
  series = {Analytical chemistry},
  volume    = {86},
  journal   = {Analytical chemistry},
  number    = {11},
  publisher = {ACS Publications},
  address   = {Columbus},
  issn      = {1520-6882 (E-Journal); 0003-2700 (Print); 0096-4484 (Print)},
  doi       = {10.1021/ac500458s},
  pages     = {5370 -- 5375},
  year      = {2014},
  abstract  = {The ideal combination among biomolecules and nanomaterials is the key for reaching biosensing units with high sensitivity. The challenge, however, is to find out a stable and sensitive film architecture that can be incorporated on the sensor's surface. In this paper, we report on the benefits of incorporating a layer-by-layer (LbL) nanofilm of polyamidoamine (PAMAM) dendrimer and carbon nanotubes (CNTs) on capacitive electrolyte-insulator-semiconductor (EIS) field-effect sensors for detecting urea. Three sensor arrangements were studied in order to investigate the adequate film architecture, involving the LbL film with the enzyme urease: (i) urease immobilized directly onto a bare EIS [EIS-urease] sensor; (ii) urease atop the LbL film over the EIS [EIS-(PAMAM/CNT)-urease] sensor; and (iii) urease sandwiched between the LbL film and another CNT layer [EIS-(PAMAM/CNT)-urease-CNT]. The surface morphology of all three urea-based EIS biosensors was investigated by atomic force microscopy (AFM), while the biosensing abilities were studied by means of capacitance-voltage (C/V) and dynamic constant-capacitance (ConCap) measureaments at urea concentrations ranging from 0.1 mM to 100 mM. The EIS-urease and EIS-(PAMAM/CNT)-urease sensors showed similar sensitivity (∼18 mV/decade) and a nonregular signal behavior as the urea concentration increased. On the other hand, the EIS-(PAMAM/CNT)-urease-CNT sensor exhibited a superior output signal performance and higher sensitivity of about 33 mV/decade. The presence of the additional CNT layer was decisive to achieve a urea based EIS sensor with enhanced properties. Such sensitive architecture demonstrates that the incorporation of an adequate hybrid enzyme-nanofilm as sensing unit opens new prospects for biosensing applications using the field-effect sensor platform.},
  language  = {en}
}
@article{SrivastavaLahiriMaitietal.2014,
  author    = {Srivastava, A. and Lahiri, S. and Maiti, M. and Knolle, F. and Hoyler, Friedrich and Scherer, Ulrich W. and Schnug, E. W.},
  title     = {Study of naturally occurring radioactive material (NORM) in top soil of Punjab State from the North Western part of India},
  series = {Journal of Radioanalytical and Nuclear Chemistry},
  volume    = {2014},
  journal   = {Journal of Radioanalytical and Nuclear Chemistry},
  number    = {302},
  publisher = {Springer Nature},
  address   = {Basel},
  issn      = {1588-2780 (E-Journal); 0022-4081 (Print); 0134-0719 (Print); 0236-5731 (Print); 1417-2097 (Print)},
  doi       = {0.1007/s10967-014-3450-1},
  pages     = {1049 -- 1052},
  year      = {2014},
  language  = {en}
}
@article{StadlerGarveyEmbsetal.2014,
  author    = {Stadler, Alexander Maximilian and Garvey, Christopher J. and Embs, Jan Peter and Koza, Michael Marek and Unruh, Tobias and Artmann, Gerhard and Zaccai, Guiseppe},
  title     = {Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study},
  series = {Biochimica et biophysica acta (BBA): General Subjects},
  volume    = {1840},
  journal   = {Biochimica et biophysica acta (BBA): General Subjects},
  number    = {10},
  publisher = {Elsevier},
  address   = {Amsterdam},
  issn      = {1872-8006 (E-Journal); 0304-4165 (Print)},
  doi       = {10.1016/j.bbagen.2014.06.007},
  pages     = {2989 -- 2999},
  year      = {2014},
  language  = {en}
}
@misc{StadtmuellerTippkoetterUlber2014,
  author    = {Stadtm{\"u}ller, R. and Tippk{\"o}tter, Nils and Ulber, Roland},
  title     = {Produktion von einzelstr{\"a}ngigen DNA-Makronukleotiden},
  series = {Chemie Ingenieur Technik},
  volume    = {86},
  journal   = {Chemie Ingenieur Technik},
  number    = {9},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {0009-286X},
  doi       = {10.1002/cite.201450372},
  pages     = {1403},
  year      = {2014},
  abstract  = {In der Biotechnologie stellt Einzelstrang-DNA (ssDNA) eine Schl{\"u}sselrolle dar und fungiert z. B. als Baustein f{\"u}r die nanoskalige Feinmechanik oder als Affinit{\"a}tsligand, ein sog. Aptamer. Hinsichtlich der industriellen Verwendung bieten Aptamere im Vergleich zu Antik{\"o}rpern viele Vorteile, wie z. B. eine gute Renaturierung bzw. die Selektion f{\"u}r cytotoxische Molek{\"u}le. Aktuell w{\"a}chst die Nachfrage f{\"u}r chim{\"a}re Aptamere von bis zu 200 n, um die simultane Bindung bzw. die Modifikation mehrerer Molek{\"u}le zu realisieren. Bis heute wird ssDNA mittels einer sequentiellen Synthese hergestellt, die eine Effizienz von ca. 99,5 \% je Zyklus und bereits bei einer Produktl{\"a}nge von 100 n nur noc hAusbeuten von max. 60 \% zeigt. Um dem Bedarf an ssDNA im Bereich > 100 n zu entsprechen, wurden zwei enzymatische Verfahren zur Produktion dieser Makronukleotide entworfen. Die erste Technik basiert auf einerFestphasen-PCR und erm{\"o}glicht sowohlein Primer- als auch ein Templatrecycling. Das zweite Verfahren beruht auf einer Plasmidbasierten In-vivo-Amplifikation, der sog. AptaGENE®-Technologie. In einer einzigen Klonierung werden bis zu 100 Kopien des Monomers in einen Vektor kloniert. Nach einer Transformation folgt der regul{\"a}re Produktionsprozess in Form einer Kultivierung, Plasmidpr{\"a}paration und sequenziellen Aufarbeitung von bis zu 6 · 10¹⁵ Makronukleotiden pro Milliliter Fermentationsvolumen.},
  language  = {de}
}
@article{Stulpe2014,
  author    = {Stulpe, Werner},
  title     = {From the attempt of certain classical reformulations of quantum mechanics to quasi-probability representations},
  series = {Journal of Mathematical Physics},
  volume    = {55},
  journal   = {Journal of Mathematical Physics},
  number    = {1},
  publisher = {AIP Publishing},
  address   = {College Park, Md.},
  issn      = {222-488},
  doi       = {10.1063/1.4861939},
  pages     = {Artikel 012109},
  year      = {2014},
  abstract  = {The concept of an injective affine embedding of the quantum states into a set of classical states, i.e., into the set of the probability measures on some measurable space, as well as its relation to statistically complete observables is revisited, and its limitation in view of a classical reformulation of the statistical scheme of quantum mechanics is discussed. In particular, on the basis of a theorem concerning a non-denseness property of a set of coexistent effects, it is shown that an injective classical embedding of the quantum states cannot be supplemented by an at least approximate classical description of the quantum mechanical effects. As an alternative approach, the concept of quasi-probability representations of quantum mechanics is considered.},
  language  = {en}
}
@article{TakenagaBiselliSchnitzleretal.2014,
  author    = {Takenaga, Shoko and Biselli, Manfred and Schnitzler, Thomas and {\"O}hlschl{\"a}ger, Peter and Wagner, Torsten and Sch{\"o}ning, Michael Josef},
  title     = {Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis-Menten-like kinetics for cell culturing},
  series = {Physica status solidi A : Applications and materials science},
  volume    = {211},
  journal   = {Physica status solidi A : Applications and materials science},
  number    = {6},
  publisher = {Wiley-VCH},
  address   = {Weinheim},
  issn      = {1521-396X (E); 1862-6319 (E-Journal); 0031-8965 (Print); 1862-6300 (Print)},
  doi       = {10.1002/pssa.201330464},
  pages     = {1410 -- 1415},
  year      = {2014},
  abstract  = {The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17-200 mM) follows a Michaelis-Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device.},
  language  = {en}
}