@inproceedings{AnicPenavaGuljasetal.2018, author = {Anic, Filip and Penava, Davorin and Guljas, Ivica and Sarhosis, Vasilis and Abrahamczyk, Lars and Butenweg, Christoph}, title = {The Effect of Openings on Out-of-Plane Capacity of Masonry Infilled Reinforced Concrete Frames}, series = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, booktitle = {16th European Conference on Earthquake Engineering, Thessaloniki, 18-21 June, 2018}, pages = {1 -- 11}, year = {2018}, language = {en} } @incollection{ArtmannMeruvuKizildagetal.2018, author = {Artmann, Gerhard and Meruvu, Haritha and Kizildag, Sefa and Temiz Artmann, Ayseg{\"u}l}, title = {Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures}, series = {Biological, Physical and Technical Basics of Cell Engineering}, booktitle = {Biological, Physical and Technical Basics of Cell Engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7904-7}, doi = {10.1007/978-981-10-7904-7_7}, pages = {157 -- 192}, year = {2018}, abstract = {Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology.}, language = {en} } @book{ArtmannTemizArtmannZhubanovaetal.2018, author = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, title = {Biological, physical and technical basics of cell engineering}, editor = {Artmann, Gerhard and Temiz Artmann, Ayseg{\"u}l and Zhubanova, Azhar A. and Digel, Ilya}, publisher = {Springer}, address = {Singapore}, isbn = {978-981-10-7903-0}, pages = {xxiv, 481 Seiten ; Illustrationen, Diagramme}, year = {2018}, language = {en} } @inproceedings{BaaderReiswichBartschetal.2018, author = {Baader, Fabian and Reiswich, M. and Bartsch, M. and Keller, D. and Tiede, E. and Keck, G. and Demircian, A. and Friedrich, M. and Dachwald, Bernd and Sch{\"u}ller, K. and Lehmann, R. and Chojetzki, R. and Durand, C. and Rapp, L. and Kowalski, Julia and F{\"o}rstner, R.}, title = {VIPER - Student research on extraterrestrical ice penetration technology}, series = {Proceedings of the 2nd Symposium on Space Educational Activities}, booktitle = {Proceedings of the 2nd Symposium on Space Educational Activities}, pages = {1 -- 6}, year = {2018}, abstract = {Recent analysis of scientific data from Cassini and earth-based observations gave evidence for a global ocean under a surrounding solid ice shell on Saturn's moon Enceladus. Images of Enceladus' South Pole showed several fissures in the ice shell with plumes constantly exhausting frozen water particles, building up the E-Ring, one of the outer rings of Saturn. In this southern region of Enceladus, the ice shell is considered to be as thin as 2 km, about an order of magnitude thinner than on the rest of the moon. Under the ice shell, there is a global ocean consisting of liquid water. Scientists are discussing different approaches the possibilities of taking samples of water, i.e. by melting through the ice using a melting probe. FH Aachen UAS developed a prototype of maneuverable melting probe which can navigate through the ice that has already been tested successfully in a terrestrial environment. This means no atmosphere and or ambient pressure, low ice temperatures of around 100 to 150K (near the South Pole) and a very low gravity of 0,114 m/s^2 or 1100 μg. Two of these influencing measures are about to be investigated at FH Aachen UAS in 2017, low ice temperature and low ambient pressure below the triple point of water. Low gravity cannot be easily simulated inside a large experiment chamber, though. Numerical simulations of the melting process at RWTH Aachen however are showing a gravity dependence of melting behavior. Considering this aspect, VIPER provides a link between large-scale experimental simulations at FH Aachen UAS and numerical simulations at RWTH Aachen. To analyze the melting process, about 90 seconds of experiment time in reduced gravity and low ambient pressure is provided by the REXUS rocket. In this time frame, the melting speed and contact force between ice and probes are measured, as well as heating power and a two-dimensional array of ice temperatures. Additionally, visual and infrared cameras are used to observe the melting process.}, language = {en} } @article{BabilonWilbringTappertetal.2018, author = {Babilon, Katharina and Wilbring, Daniela and Tappert, Tim and Pfaff, Raphael and Enning, Manfred}, title = {Schienenfahrzeugtechnik hands on - FH Aachen IMechE Railway Challenge}, series = {Ingenieurspiegel}, journal = {Ingenieurspiegel}, number = {2}, publisher = {Public Verlag}, address = {Bingen}, issn = {1868-5919}, pages = {20 -- 22}, year = {2018}, language = {de} } @article{BalakirskiKotliarPaulyetal.2018, author = {Balakirski, Galina and Kotliar, Konstantin and Pauly, Karolin J. and Krings, Laura K. and R{\"u}bben, Albert and Baron, Jens M. and Schmitt, Laurenz}, title = {Surgical Site Infections After Dermatologic Surgery in Immunocompromised Patients: A Single-Center Experience}, series = {Dermatologic Surgery}, journal = {Dermatologic Surgery}, number = {44 (12)}, publisher = {Wolters Kluwer}, doi = {10.1097/DSS.0000000000001615}, pages = {1525 -- 1536}, year = {2018}, abstract = {BACKGROUND Immunosuppression is often considered as an indication for antibiotic prophylaxis to prevent surgical site infections (SSI) while performing skin surgery. However, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. PATIENTS AND METHODS All patients of the Department of Dermatology and Allergology at the University Hospital of RWTH Aachen in Aachen, Germany, who underwent hospitalization for a dermatologic surgery between June 2016 and January 2017 (6 months), were followed up after surgery until completion of the wound healing process. The follow-up addressed the occurrence of SSI and the need for systemic antibiotics after the operative procedure. Immunocompromised patients were compared with immunocompetent patients. The investigation was conducted as a retrospective analysis of patient records. RESULTS The authors performed 284 dermatologic surgeries in 177 patients. Nineteen percent (54/284) of the skin surgery was performed on immunocompromised patients. The most common indications for surgical treatment were nonmelanoma skin cancer and malignant melanomas. Surgical site infections occurred in 6.7\% (19/284) of the cases. In 95\% (18/19), systemic antibiotic treatment was needed. Twenty-one percent of all SSI (4/19) were seen in immunosuppressed patients. CONCLUSION According to the authors' data, immunosuppression does not represent a significant risk factor for SSI after dermatologic surgery. However, larger prospective studies are needed to make specific recommendations on the use of antibiotic prophylaxis while performing skin surgery in these patients. The available data on complications after dermatologic surgery have improved over the past years. Particularly, additional risk factors have been identified for surgical site infections (SSI). Purulent surgical sites, older age, involvement of head, neck, and acral regions, and also the involvement of less experienced surgeons have been reported to increase the risk of the SSI after dermatologic surgeries.1 In general, the incidence of SSI after skin surgery is considered to be low.1,2 However, antibiotics in dermatologic surgeries, especially in the perioperative setting, seem to be overused,3,4 particularly regarding developing antibiotic resistances and side effects. Immunosuppression has been recommended to be taken into consideration as an additional indication for antibiotic prophylaxis to prevent SSI after skin surgery in special cases.5,6 However, these recommendations do not specify the exact dermatologic surgeries, and were not specifically developed for dermatologic surgery patients and treatments, but adopted from other surgical fields.6 According to the survey conducted on American College of Mohs Surgery members in 2012, 13\% to 29\% of the surgeons administered antibiotic prophylaxis to immunocompromised patients to prevent SSI while performing dermatologic surgery on noninfected skin,3 although this was not recommended by Journal of the American Academy of Dermatology Advisory Statement. Indeed, the data on the risk of developing SSI after dermatologic surgery in immunosuppressed patients are limited. However, it is possible that due to the insufficient evidence on the risk of SSI occurrence in this patient group, dermatologic surgeons tend to overuse perioperative antibiotic prophylaxis. To make specific recommendations on the use of antibiotic prophylaxis in immunosuppressed patients in the field of skin surgery, more information about the incidence of SSI after dermatologic surgery in these patients is needed. The aim of this study was to fill this data gap by investigating whether there is an increased risk of SSI after skin surgery in immunocompromised patients compared with immunocompetent patients.}, language = {en} } @article{BaringhausGaigall2018, author = {Baringhaus, Ludwig and Gaigall, Daniel}, title = {Efficiency comparison of the Wilcoxon tests in paired and independent survey samples}, series = {Metrika}, volume = {2018}, journal = {Metrika}, number = {81}, publisher = {Springer}, address = {Berlin}, issn = {1435-926X}, doi = {10.1007/s00184-018-0661-4}, pages = {891 -- 930}, year = {2018}, abstract = {The efficiency concepts of Bahadur and Pitman are used to compare the Wilcoxon tests in paired and independent survey samples. A comparison through the length of corresponding confidence intervals is also done. Simple conditions characterizing the dominance of a procedure are derived. Statistical tests for checking these conditions are suggested and discussed.}, language = {de} } @article{BaringhausGaigallThiele2018, author = {Baringhaus, Ludwig and Gaigall, Daniel and Thiele, Jan Philipp}, title = {Statistical inference for L²-distances to uniformity}, series = {Computational Statistics}, volume = {2018}, journal = {Computational Statistics}, number = {33}, publisher = {Springer}, address = {Berlin}, issn = {1613-9658}, doi = {10.1007/s00180-018-0820-0}, pages = {1863 -- 1896}, year = {2018}, abstract = {The paper deals with the asymptotic behaviour of estimators, statistical tests and confidence intervals for L²-distances to uniformity based on the empirical distribution function, the integrated empirical distribution function and the integrated empirical survival function. Approximations of power functions, confidence intervals for the L²-distances and statistical neighbourhood-of-uniformity validation tests are obtained as main applications. The finite sample behaviour of the procedures is illustrated by a simulation study.}, language = {en} } @inproceedings{BensbergAuthCzarnecki2018, author = {Bensberg, Frank and Auth, Gunnar and Czarnecki, Christian}, title = {Unterst{\"u}tzung von Wissenstransferprozessen durch Erschließung von Literaturdatenbanken - ein gestaltungsorientierter Ansatz auf Basis von Text Analytics}, series = {Wissenstransfer in der Wirtschaftsinformatik Fachgespr{\"a}ch im Rahmen der MKWI 2018}, booktitle = {Wissenstransfer in der Wirtschaftsinformatik Fachgespr{\"a}ch im Rahmen der MKWI 2018}, editor = {Hofmann, Georg Rainer and Alm, Wolfgang}, publisher = {IMI-Verlag ; Hochschule Aschaffenburg, Information Management Institut}, address = {Aschaffenburg}, isbn = {9783981844207}, pages = {6 -- 15}, year = {2018}, abstract = {Angesichts des anhaltenden Wachstums wissenschaftlicher Ver{\"o}ffentlichungen werden Instrumente ben{\"o}tigt, um Literaturanalysen durch Digitalisierung produktiver zu gestalten. Dieser Beitrag stellt einen Ansatz vor, der bibliographische Daten aus der Literaturdatenbank EBSCO Discovery Service mithilfe von Text-Analytics-Methoden erschließt. Die L{\"o}sung basiert auf dem Textanalysesystem IBM Watson Explorer und eignet sich f{\"u}r explorative Literaturanalysen, um beispielsweise den Status quo emergierender Technologiefelder in der Literatur zu reflektieren. Die generierten Ergebnisse sind in den Kontext der zunehmenden Werkzeugunterst{\"u}tzung des Literaturrechercheprozesses einzuordnen und k{\"o}nnen f{\"u}r intra- sowie interinstitutionelle Wissenstransferprozesse in Forschungs- und Beratungskontexten genutzt werden.}, language = {de} } @article{BensbergAuthCzarnecki2018, author = {Bensberg, Frank and Auth, Gunnar and Czarnecki, Christian}, title = {Einsatz von Text Analytics zur Unterst{\"u}tzung literaturintensiver Forschungsprozesse: Konzeption, Realisierung und Lessons Learned}, series = {Anwendungen und Konzepte der Wirtschaftsinformatik}, volume = {2018}, journal = {Anwendungen und Konzepte der Wirtschaftsinformatik}, number = {8}, publisher = {AKWI}, address = {Luzern}, issn = {2296-4592}, doi = {10.26034/lu.akwi.2018.3221}, pages = {1 -- 6}, year = {2018}, abstract = {Das anhaltende Wachstum wissenschaftlicher Ver{\"o}ffentlichungen wirft die Fragestellung auf, wie Literaturana-lysen im Rahmen von Forschungsprozessen digitalisiert und somit produktiver realisiert werden k{\"o}nnen. Insbesondere in informationstechnischen Fachgebieten ist die Forschungspraxis durch ein rasant wachsendes Publikationsaufkommen gekennzeichnet. Infolgedessen bietet sich der Einsatz von Methoden der Textanalyse (Text Analytics) an, die Textdaten automatisch vorbereiten und verarbeiten k{\"o}nnen. Erkenntnisse entstehen dabei aus Analysen von Wortarten und Subgruppen, Korrelations- sowie Zeitreihenanalysen. Dieser Beitrag stellt die Konzeption und Realisierung eines Prototypen vor, mit dem Anwender bibliographische Daten aus der etablierten Literaturdatenbank EBSCO Discovery Service mithilfe textanalytischer Methoden erschließen k{\"o}nnen. Der Prototyp basiert auf dem Analysesystem IBM Watson Explorer, das Hochschulen lizenzkostenfrei zur Verf{\"u}gung steht. Potenzielle Adressaten des Prototypen sind Forschungseinrichtungen, Beratungsunternehmen sowie Entscheidungstr{\"a}ger in Politik und Unternehmenspraxis.}, language = {de} }