@article{EngelmannBuhlDraacketal.2018, author = {Engelmann, Ulrich M. and Buhl, Eva Miriam and Draack, Sebastian and Viereck, Thilo and Frank, and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Magnetic relaxation of agglomerated and immobilized iron oxide nanoparticles for hyperthermia and imaging applications}, series = {IEEE Magnetic Letters}, volume = {9}, journal = {IEEE Magnetic Letters}, number = {Article number 8519617}, publisher = {IEEE}, address = {New York, NY}, issn = {1949-307X}, doi = {10.1109/LMAG.2018.2879034}, year = {2018}, abstract = {Magnetic nanoparticles (MNPs) are used as therapeutic and diagnostic agents for local delivery of heat and image contrast enhancement in diseased tissue. Besides magnetization, the most important parameter that determines their performance for these applications is their magnetic relaxation, which can be affected when MNPs immobilize and agglomerate inside tissues. In this letter, we investigate different MNP agglomeration states for their magnetic relaxation properties under excitation in alternating fields and relate this to their heating efficiency and imaging properties. With focus on magnetic fluid hyperthermia, two different trends in MNP heating efficiency are measured: an increase by up to 23\% for agglomerated MNP in suspension and a decrease by up to 28\% for mixed states of agglomerated and immobilized MNP, which indicates that immobilization is the dominant effect. The same comparatively moderate effects are obtained for the signal amplitude in magnetic particle spectroscopy.}, language = {en} } @article{EngelmannRoethEberbecketal.2018, author = {Engelmann, Ulrich M. and Roeth, Anjali A.J. and Eberbeck, Dietmar and Buhl, Eva Miriam and Neumann, Ulf Peter and Schmitz-Rode, Thomas and Slabu, Ioana}, title = {Combining Bulk Temperature and Nanoheating Enables Advanced Magnetic Fluid Hyperthermia Efficacy on Pancreatic Tumor Cells}, series = {Scientific Reports}, volume = {8}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, address = {Cham}, issn = {2045-2322}, doi = {10.1038/s41598-018-31553-9}, pages = {Article number 13210}, year = {2018}, abstract = {Many efforts are made worldwide to establish magnetic fluid hyperthermia (MFH) as a treatment for organ-confined tumors. However, translation to clinical application hardly succeeds as it still lacks of understanding the mechanisms determining MFH cytotoxic effects. Here, we investigate the intracellular MFH efficacy with respect to different parameters and assess the intracellular cytotoxic effects in detail. For this, MiaPaCa-2 human pancreatic tumor cells and L929 murine fibroblasts were loaded with iron-oxide magnetic nanoparticles (MNP) and exposed to MFH for either 30 min or 90 min. The resulting cytotoxic effects were assessed via clonogenic assay. Our results demonstrate that cell damage depends not only on the obvious parameters bulk temperature and duration of treatment, but most importantly on cell type and thermal energy deposited per cell during MFH treatment. Tumor cell death of 95\% was achieved by depositing an intracellular total thermal energy with about 50\% margin to damage of healthy cells. This is attributed to combined intracellular nanoheating and extracellular bulk heating. Tumor cell damage of up to 86\% was observed for MFH treatment without perceptible bulk temperature rise. Effective heating decreased by up to 65\% after MNP were internalized inside cells.}, language = {en} } @inproceedings{EngemannWiesenKallweitetal.2018, author = {Engemann, Heiko and Wiesen, Patrick and Kallweit, Stephan and Deshpande, Harshavardhan and Schleupen, Josef}, title = {Autonomous mobile manipulation using ROS}, series = {Advances in Service and Industrial Robotics}, booktitle = {Advances in Service and Industrial Robotics}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-61276-8}, doi = {10.1007/978-3-319-61276-8_43}, pages = {389 -- 401}, year = {2018}, language = {en} } @article{ErmolaevNivokovMelnikovaetal.2018, author = {Ermolaev, A.P. and Nivokov, I.A. and Melnikova, L.I. and Kotliar, Konstantin}, title = {Сравнительная характеристика химического состава витреального содержимого кадаверных глаз и глаз с рефрактерной терминальной глаукомой}, series = {Vestnik oftalmologii}, volume = {5}, journal = {Vestnik oftalmologii}, number = {2}, publisher = {Media Sfera}, address = {Moskau}, doi = {10.17116/oftalma2018134051195}, pages = {195 -- 201}, year = {2018}, abstract = {Purpose — to compare the chemical elemental composition of vitreous cavity content taken from cadaveric eyes compared to samples taken from the eyes with terminal stage refractory glaucoma with decompensated intraocular pressure (IOP). Material and methods. The vitreous contents of the eyes from 2 groups were studied. The 1st group included 15 cadaveric eyes; the 2nd group included 15 eyes with refractory glaucoma in the terminal stage of the disease with decompensated IOP in patients with hypertension pain. The vitreal content samples were taken in the course of antiglaucoma surgery aimed at preserving the eye as an organ and involving employment of drainage in the vitreous cavity. The study of virtual contents was carried out on energy dispersive spectrometer Oxford X-Max 50 integrated into scanning electron microscope Zeiss EVO LS10. Results. Increased concentrations of Kalium and Phosphorus were detected in the vitreous content of cadaveric eyes compared with the vitreal content from the eyes with terminal glaucoma with decompensated IOP taken in vivo (K — 0.172/0.093; P — 0.045/0.025 mmol/L). In the vitreous cavity in the eyes with end-stage glaucoma with decompensated IOP, the concentration of Nitrogen was higher in comparison with human cadaver eyes (2.030/1.424 mmol/L). Conclusion. The increased concentrations of Kalium and Phosphorus in the vitreous content of cadaveric eyes is associated with postmortem autolytic processes and with the release of intracellular content in the destruction of cell membranes. The increased Nitrogen concentration in the vitreal contents of the eyes with terminal stage glaucoma with decompensated IOP may be associated with the presence of osmotically active nitrogen-containing compounds in the eyes with increased IOP.}, language = {ru} } @inproceedings{EssingholtMeyerKuhnetal.2018, author = {Essingholt, Felix and Meyer, Frederic and Kuhn, Peter and Schmidt, Philip and Benkner, Thorsten and Grabmaier, Anton}, title = {Non-invasive heart beat measurement using microwave resonators}, series = {Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9-12 September 2018}, booktitle = {Proceedings, Vol. 2, Eurosensors 2018 Conference, Graz, Austria, 9-12 September 2018}, publisher = {MDPI}, address = {Basel}, issn = {2504-3900}, doi = {10.3390/proceedings2131002}, pages = {1002}, year = {2018}, language = {en} } @incollection{Fabo2018, author = {Fabo, Sabine}, title = {Einspr{\"u}che gegen den informierten Himmel ; Wegsehen; Distanzschaffen, Spielen}, series = {Orbitale Irritationen / Herausgeber: REMOTEWORDS: Achim Mohn{\´e} \& Uta Kopp}, booktitle = {Orbitale Irritationen / Herausgeber: REMOTEWORDS: Achim Mohn{\´e} \& Uta Kopp}, publisher = {Herbert von Halem Verlag}, address = {K{\"o}ln}, isbn = {978-3-86962-302-3}, pages = {20 -- 45}, year = {2018}, language = {de} } @incollection{Fabo2018, author = {Fabo, Sabine}, title = {Eine dekonstruktive Erinnerungsarbeit}, series = {Doris Frohnapfel, bewaffnete G{\"o}tter = Doris Frohnapfel, armed gods}, booktitle = {Doris Frohnapfel, bewaffnete G{\"o}tter = Doris Frohnapfel, armed gods}, publisher = {RpB Richter-Br{\"u}ckner}, address = {K{\"o}ln}, isbn = {978-3-9817241-2-7}, pages = {31 -- 35}, year = {2018}, language = {de} } @inproceedings{FerreinSchifferKallweit2018, author = {Ferrein, Alexander and Schiffer, Stefan and Kallweit, Stephan}, title = {The ROSIN Education Concept - Fostering ROS Industrial-Related Robotics Education in Europe}, series = {ROBOT 2017: Third Iberian Robotics Conference}, booktitle = {ROBOT 2017: Third Iberian Robotics Conference}, publisher = {Springer}, address = {Cham}, isbn = {978-3-319-70836-2}, doi = {10.1007/978-3-319-70836-2_31}, pages = {370 -- 381}, year = {2018}, language = {en} } @article{FigueroaMirandaFengShiuetal.2018, author = {Figueroa-Miranda, Gabriela and Feng, Lingyan and Shiu, Simon Chi-Chin and Dirkzwager, Roderick Marshall and Cheung, Yee-Wai and Tanner, Julian Alexander and Sch{\"o}ning, Michael Josef and Offenh{\"a}usser, Andreas and Mayer, Dirk}, title = {Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability}, series = {Sensor and Actuators B: Chemical}, volume = {255}, journal = {Sensor and Actuators B: Chemical}, number = {P1}, publisher = {Elsevier}, address = {Amsterdam}, issn = {0925-4005}, doi = {10.1016/j.snb.2017.07.117}, pages = {235 -- 243}, year = {2018}, abstract = {Malaria infection remains a significant risk for much of the population of tropical and subtropical areas, particularly in developing countries. Therefore, it is of high importance to develop sensitive, accurate and inexpensive malaria diagnosis tests. Here, we present a novel aptamer-based electrochemical biosensor (aptasensor) for malaria detection by impedance spectroscopy, through the specific recognition between a highly discriminatory DNA aptamer and its target Plasmodium falciparum lactate dehydrogenase (PfLDH). Interestingly, due to the isoelectric point (pI) of PfLDH, the aptasensor response showed an adjustable detection range based on the different protein net-charge at variable pH environments. The specific aptamer recognition allows sensitive protein detection with an expanded detection range and a low detection limit, as well as a high specificity for PfLDH compared to analogous proteins. The specific feasibility of the aptasensor is further demonstrated by detection of the target PfLDH in human serum. Furthermore, the aptasensor can be easily regenerated and thus applied for multiple usages. The robustness, sensitivity, and reusability of the presented aptasensor make it a promising candidate for point-of-care diagnostic systems.}, language = {en} } @inproceedings{FingerBraunBil2018, author = {Finger, Felix and Braun, Carsten and Bil, Cees}, title = {Case studies in initial sizing for hybrid-electric general aviation aircraft}, series = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio}, booktitle = {2018 AIAA/IEEE Electric Aircraft Technologies Symposium, Cincinnati, Ohio}, doi = {10.2514/6.2018-5005}, year = {2018}, language = {en} }