Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-8976 Wissenschaftlicher Artikel Özsoylu, Dua, ; Kizildag, Sefa, dua.oezsoylu@alumni.fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Effect of plasma treatment on the sensor properties of a light-addressable potentiometric sensor (LAPS) A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment. Weinheim Wiley 2019 8 Seiten physica status solidi a : applications and materials sciences 216 Corresponding author: Torsten Wagner 20 10.1002/pssa.201900259 weltweit https://doi.org/10.1002/pssa.201900259 Fachbereich Medizintechnik und Technomathematik OPUS4-9332 Wissenschaftlicher Artikel Özsoylu, Dua, oezsoylu@fh-aachen.de; Kizildag, Sefa, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS) Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images. Amsterdam Elsevier 2020 8 Physics in Medicine 10 100030 10.1016/j.phmed.2020.100030 weltweit https://doi.org/10.1016/j.phmed.2020.100030 Fachbereich Medizintechnik und Technomathematik OPUS4-5038 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Kleines, H., ; Erken, I., ; Knoben, J., ; Zwoll, K., Lehmann, Thomas IME-DV Projekt: M-FIRBe, Multi-Modality Functional Imaging for Brain Research Aachen Verl. der. Augustinus-Buchh. 1997 3 Bildverarbeitung für die Medizin : Algorithmen - Systeme - Anwendungen 3-86073-519-5 Proceedings des Aachener Workshops am 8. u. 9. November 1996 ; WG_005 Arbeitsgruppenvorstellungen 363 366 Fachbereich Medizintechnik und Technomathematik OPUS4-5032 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Herzog, H., ; Feinendegen, L. E., Iterative image reconstruction with weighted pixel contribution to projection element 1990 0 European Journal of Nuclear Medicine 16 1619-7089 Abstracts of the European Association of Nuclear Medicine Congress ; V52 7 403 403 campus http://dx.doi.org/10.1007/BF02266927 Fachbereich Medizintechnik und Technomathematik OPUS4-5035 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Herzog, H., ; Bosetti, P., ; Feinendegen, L. E., Iterative image reconstruction with weighted pixel contribution to projection elements 1992 0 European Journal of Nuclear Medicine 19 1619-7089 Abstracts of the European Association of Nuclear Medicine Congress 23-26 August 1992 Lisboa, Portugal ; V143-2 8 588 588 campus http://dx.doi.org/10.1007/BF00596386 Fachbereich Medizintechnik und Technomathematik OPUS4-5068 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Heinrichs, U., ; Streun, M., ; Pietrzyk, U., Validation of GEANT3 simulation studies with a dual-head PMT ClearPET™ prototype The ClearPET™ project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2nd generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET™ camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0% the simulated intrinsic resolution is about (1.41±0.11)mm compared to the measured of (1.48±0.06)mm. The simulated sensitivity profiles show a mean square deviation of 12.6% in axial direction and 3.6% in radial direction. Satisfactorily these results are representative for all designs and confirm the scanner geometry. 2004 3 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5 3053 3056 campus http://dx.doi.org/10.1109/NSSMIC.2003.1352542 Fachbereich Medizintechnik und Technomathematik OPUS4-5085 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Bruyndonckx, P., ; Perez, J. M., ; Pietrzyk, U., ; Rato, P., ; Tavernier, S., Beyond ClearPET: Next Aims The CRYSTAL CLEAR collaboration, in short CCC, is a consortium of 12 academic institutions, mainly from Europe, joining efforts in the area of developing instrumentation for nuclear medicine and medical imaging. In the framework of the CCC a high performance small animal PET system, called ClearPET, was developed by using new technologies in electronics and crystals in a phoswich arrangement combining two types of lutetium- based scintillator materials: LSO:Ce and LuYAP:Ce. Our next aim will be the development of hybrid image systems. Hybrid MR-PET imaging has many unique advantages for brain research. This has sparked a new research line within CCC for the development of novel MR-PET compatible technologies. MRI is not as sensitive as PET but PET has poorer spatial resolution than MRI. Two major advantages of PET are sensitivity and its ability to acquire metabolic information. To assess these innovations, the development of a 9.4T hybrid animal MR-PET scanner is proposed based on an existing 9.4T MR scanner that will be adapted to enable simultaneous acquisition of MR and PET data using cutting- edge technology for both MR and PET. 2008 3 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro Symposium Proceedings ISBI 2008 978-1-4244-2003-2 1421 1424 campus http://dx.doi.org/10.1109/ISBI.2008.4541273 Fachbereich Medizintechnik und Technomathematik OPUS4-5029 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Berghoff, G., ; Lanske, D., ; Schultze, K., Strangeness production in deep inelastic muon-nucleon scattering 1988 NaN Verhandlungen der Deutschen Physikalischen Gesellschaft 23 0420-0195 5 T309 T309 Fachbereich Medizintechnik und Technomathematik OPUS4-5071 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Auffray, E., ; Barbier, R., ; Brandenburg, G., ; Bruyndonckx, P., The ClearPET™ project: Development of a 2nd generation high-performance small animal PET scanner Second generation high-performance PET scanners, called ClearPET™1, have been developed by working groups of the Crystal Clear Collaboration (CCC). High sensitivity and high spatial resolution for the ClearPET camera is achieved by using a phoswich arrangement combining two different types of lutetium-based scintillator materials: LSO from CTI and LuYAP:Ce from the CCC (ISTC project). In a first ClearPET prototype, phoswich arrangements of 8×8 crystals of 2×2×10 mm3 are coupled to multi-channel photomultiplier tubes (Hamamatsu R7600). A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the ring is 120 mm, the axial detector length is 110 mm.The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the exact pulse starting time, which is subsequently used for coincidence detection. The gantry allows rotation of the detector modules around the field of view. Preliminary data shows a correct identification of the crystal layer about (98±1)%. Typically the energy resolution is (23.3±0.5)% for the luyap layer and (15.4±0.4)% for the lso layer. early studies showed the timing resolution of 2 ns FWHM and 4.8 ns FWTM. the intrinsic spatial resolution ranges from 1.37 mm to 1.61 mm full-width of half-maximum (FWHM) with a mean of 1.48 mm FWHM. further improvements in image and energy resolution are expected when the system geometry is fully modeled. 2005 4 Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 537 Proceedings of the 7th International Conference on Inorganic Scintillators and their Use in Scientific and Industrial Applications 1-2 307 311 campus http://dx.doi.org/10.1016/j.nima.2004.08.032 Fachbereich Medizintechnik und Technomathematik OPUS4-5065 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Auffray, E., ; Barbier, R., ; Brandenburg, G., The ClearPET TM LSO/LuYAP phoswich scanner: a high performance small animal PET system A 2nd generation high performance small animal PET scanner, called ClearPET™, has been designed and a first prototype is built by working groups of the Crystal Clear Collaboration (CCC). In order to achieve high sensitivity and maintain good uniform spatial resolution over the field of view in high resolution PET systems, it is necessary to extract the depth of interaction (DOI) information and correct for spatial degradation. The design of the first ClearPET™ Demonstrator based on the use of the multi-anode photomultiplier tube (Hamamatsu R7600-M64) and a LSO/LuYAP phoswich matrix. The two crystal layers of 8*8 crystals (2*2*10 mm3) are stacked on each other and mounted without light guide as one to one on the PMT. A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the crystal ring is 137 mm, the axial detector length is 110 mm. The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the pulse arrival time. Single gamma interactions are recorded and coincidences are found by software. The gantry allows rotation of the detector modules around the field of view. The measurements have been done using the first LSO/LuYAP detector cassettes. 2004 4 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 3 1728 1732 campus http://dx.doi.org/10.1109/NSSMIC.2003.1352212 Fachbereich Medizintechnik und Technomathematik OPUS4-3475 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Achten, R., ; Auffray, E., ; Müller-Veggian, Mattea, mueller-veggian@opus.fh-aachen.de The ClearPET™ neuro scanner: a dedicated LSO/LuYAP phoswich small animal PET scanner Piscataway, NJ IEEE Operations Center 2004 3 2004 IEEE Nuclear Science Symposium conference record : Nuclear Science Symposium, Medical Imaging Conference ; 16 - 22 October 2004, Rome, Italy ; [including the Symposium on Nuclear Power System (SNPS), 14th Room Temperature Semiconductor X- and Gamma-Ray Detectors Workshop and special focus workshops] / NPSS, Nuclear & Plasma Sciences Society. Guest ed.: J. Anthony Seibert Nuclear Science Symposium Conference Record, 2004 IEEE 2430 2433 campus https://doi.org/10.1109/NSSMIC.2004.1462747 Fachbereich Medizintechnik und Technomathematik OPUS4-5036 Wissenschaftlicher Artikel Ziemons, Karl, A measurement of the ratio of the nucleon structure function in copper and deuterium Results are presented on the ratios of the nucleon structure function in copper to deuterium from two separate experiments. The data confirm that the nucleon structure function,F 2, is different for bound nucleons than for the quasi-free ones in the deuteron. The redistribution in the fraction of the nucleon's momentum carried by quarks is investigated and it is found that the data are compatible with no integral loss of quark momenta due to nuclear effects. 1993 7 Zeitschrift für Physik C Particles and Fields 57 1431-5858 European Muon Collaboration 2 211 218 campus http://dx.doi.org//10.1007/BF01565050 Fachbereich Medizintechnik und Technomathematik OPUS4-5027 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de Jet production and fragmentation properties in deep inelastic muon scattering 1987 16 Zeitschrift für Physik C : Particles and Fields 36 0170-9739 European Muon Collaboration 4 527 543 campus http://dx.doi.org/10.1007/BF01630590 Fachbereich Medizintechnik und Technomathematik OPUS4-5028 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de A measurement of the spin asymmetry of the structure function g1 in deep inelastic muon-proton scattering The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured over a large x range (0.01http://dx.doi.org/10.1016/0370-2693(88)91523-7 Fachbereich Medizintechnik und Technomathematik OPUS4-5031 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de An investigation of the spin structure of the proton in deep inelastic scattering of polarised muons and polarised protons The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured in the range 0.01<×<0.7. The spin dependent structure function g1(x) for the proton has been determined and, combining the data with earlier SLAC measurements, its integral over x found to be 0.126±0.010(stat.)±0.015(syst.), in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Biorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These integrals lead to the conclusion, in the naïve quark parton model, that the total quark spin constitutes a rather small fraction of the spin of the nucleon. Results are also presented on the asymmetries in inclusive hadron production which are consistent with the above picture. 1989 34 Nuclear Physics B 328 0550-3213 European Muon Collaboration 1 1 35 campus http://dx.doi.org/10.1016/0550-3213(89)90089-8 Fachbereich Medizintechnik und Technomathematik OPUS4-5033 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de Comparison of forward hadrons produced in muon interactions on nuclear targets and deuterium Differential multiplicities of forward produced hadrons in deep inelastic muon scattering on nuclear targets have been compared with those from deuterium. The ratios are observed to increase towards unity as the virtual photon energy increases with no significant dependence on the other muon kinematic variables. The hadron transverse momentum distribution is observed to be broadened in nuclear targets. The dependence on the remaining hadron variables is investigated and the results are discussed in the framework of intranuclear interaction models and in the context of the EMC effect. 1991 10 Zeitschrift für Physik C Particles and Fields 52 1431-5858 European Muon Collaboration 1 1 11 campus http://dx.doi.org/10.1007/BF01412322 Fachbereich Medizintechnik und Technomathematik OPUS4-5034 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de Muoproduction of J/ψ and the gluon distribution of the nucleon Measurements are presented of the inclusive distributions of the J/Ψ meson produced by muons of energy 200 GeV from an ammonia target. The gluon distribution of the nucleon has been derived from the data in the range 0.04http://dx.doi.org/10.1007/BF01589703 Fachbereich Medizintechnik und Technomathematik OPUS4-9114 Wissenschaftlicher Artikel Zhubanova, А., ; Mansurov, Z.A., ; Digel, Ilya, ; Saviskaya, I.S., ; Akimbekov, N.Sh., Designing of Heterogeneous Nanobiocomposites for Biotechnology 2013 4 KazNU Bulletin. Biology series 59 1563-0218 No 3/1 89 93 Fachbereich Medizintechnik und Technomathematik OPUS4-321 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells. 2007 Fachbereich Medizintechnik und Technomathematik OPUS4-319 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Aknazarov, S. K., ; Mansurov, Zulkhair, ; Digel, Ilya, digel@fh-aachen.de; Kozhalakova, A. A., ; Akimbekov, Nuraly Shardarbekovich, ; O'Heras, Carlos, ; Tazhibayeva, S., ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment. 2010 Fachbereich Medizintechnik und Technomathematik OPUS4-11083 Wissenschaftlicher Artikel Zhen, Manghao, ; Liang, Yunpei, ; Staat, Manfred, m.staat@fh-aachen.de; Li, Quanqui, ; Li, Jianbo, Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress-strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress-strain curves of the fissured sandstone specimens. Amsterdam Elsevier 2024 13 Seiten Theoretical and Applied Fracture Mechanics 131 Art. No. 104373 10.1016/j.tafmec.2024.104373 campus https://doi.org/10.1016/j.tafmec.2024.104373 Fachbereich Medizintechnik und Technomathematik OPUS4-4907 Wissenschaftlicher Artikel Zerlin, Kay, zerlin@fh-aachen.de; Kasischke, Nicole, ; Digel, Ilya, digel@fh-aachen.de; Maggakis-Kelemen, Christina, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Structural transition temperature of hemoglobins correlates with species' body temperature 2007 9 European Biophysics Journal. 37 (2007), H. 1 1432-1017 1 10 campus http://dx.doi.org/10.1007/s00249-007-0144-4 Fachbereich Medizintechnik und Technomathematik OPUS4-4905 Wissenschaftlicher Artikel Zerlin, Kay, zerlin@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Stadler, Andreas M., ; Büldt, Georg, ; Zaccai, Guiseppe, ; Artmann, Gerhard, artmann@fh-aachen.de Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions 2007 0 Regenerative medicine. 2 (2007), H. 5 1746-0751 Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany 573 573 bezahl http://dx.doi.org/10.2217/17460751.2.5.485 Fachbereich Medizintechnik und Technomathematik OPUS4-7959 Wissenschaftlicher Artikel Zange, Jochen, ; Schopen, Kathrin, ; Albracht, Kirsten, albracht@fh-aachen.de; Gerlach, Darius A., ; Frings-Meuthen, Petra, ; Maffiuletti, Nicola A., ; Bloch, Wilhelm, ; Rittweger, Jörn, Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial 2017 Plos one 12 2 10.1371/journal.pone.0171562 Fachbereich Medizintechnik und Technomathematik OPUS4-9536 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors (LAPS) for cell monitoring and biosensing Amsterdam Elsevier 2021 Current Opinion in Electrochemistry In Press, Journal Pre-proof 10.1016/j.coelec.2021.100727 bezahl https://doi.org/10.1016/j.coelec.2021.100727 Fachbereich Medizintechnik und Technomathematik OPUS4-7288 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Moritz, Werner, ; Finger, Friedhelm, ; Schöning, Michael Josef, schoening@fh-aachen.de Comini, Elisabetta Application of thin-film amorphous silicon to chemical imaging 2006 9 Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. 9781558998711 Materials Research Society symposia proceedings; v. 915 Paper 0910-A-20-01 1 10 Fachbereich Medizintechnik und Technomathematik OPUS4-8064 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-ichiro, ; Werner, Frederik, f.werner@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species 2017 21 Annual Review of Analytical Chemistry 10 225 246 10.1146/annurev-anchem-061516-045158 Fachbereich Medizintechnik und Technomathematik OPUS4-4682 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-Ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Miniaturized and high-speed chemical imaging systems - 2012 9 Nano-Boomedical Engineering 2012 :Proceedings of the Tohoku University Global Centre of Excellence Programme / Sakura Hall, Tohoku University, Sendai Japan, 5 – 6 March 2012 / ed. by Takami Yamaguchi 386 395 bezahl http://dx.doi.org/10.1142/9781848169067_0045 Fachbereich Medizintechnik und Technomathematik OPUS4-6666 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor Amsterdam Elsevier 2015 6 Sensors and actuators B: Chemical 207 Part B 926 932 campus https://dx.doi.org/10.1016/j.snb.2014.09.002 Fachbereich Medizintechnik und Technomathematik OPUS4-1965 Wissenschaftlicher Artikel Yoshinobu, T., ; Yasuhito, U., ; Iwasaki, H., ; Näther, Niko, naether@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Koudelka-Hep, M., Applications of the light-addressable potentiometric sensor to microfluidic devices Roma 2004 790 S.: Ill., graph. Darst. 1 CD-ROM Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale]. 88-7621-282-5 Eurosensors ; (18, 2004, Roma) 434 437 Fachbereich Medizintechnik und Technomathematik OPUS4-1755 Wissenschaftlicher Artikel Yoshinobu, T., ; Ui, Y., ; Iwasaki, H., ; Näther, Niko, naether@fh-aachen.de; Koudelka-Hep, M., ; Schöning, Michael Josef, schoening@fh-aachen.de Potentiometric imaging in a microfluidic channel 2004 1 Biomedizinische Technik. 49 (2004), H. 2 0932-4666 998 999 Fachbereich Medizintechnik und Technomathematik OPUS4-1979 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Furuichi, K., ; Mourzina, Yu, ; Ermelenko, Yu, ; Iwasaki, I., Portable light-addressable potentiometric sensor (LAPS) for multisensor applications Prague Czech Technical University, Faculty of Electrical Engineering, Department of Measurement 2002 3 Book of abstracts / ed. by J. Saneistr. 80-01-02576-4 Eurosensors ; (16, 2002, Praha) 898 901 Fachbereich Medizintechnik und Technomathematik OPUS4-1768 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Furuichi, K., ; Mourzina, Y., ; Ermelenko, Y., ; Iwasaki, H., Portable light-addressable potentiometric sensor (LAPS) for multisensor applications 2003 4 Sensors and Actuators B. 95 (2003), H. 1-3 0925-4005 352 356 campus http://dx.doi.org/10.1016/S0925-4005(03)00437-4 Fachbereich Medizintechnik und Technomathematik OPUS4-1751 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Finger, F., ; Moritz, W., ; Iwasaki, H., Fabrication of thin-film LAPS with amorphous silicon 2004 6 Sensors. 4 (2004), H. 10 1424-8220 163 169 weltweit http://www.mdpi.org/sensors/papers/s41000163.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-1954 Wissenschaftlicher Artikel Yoshinobu, T., ; Iwasaki, H., ; Ui, Y., ; Furuichi, K., ; Ermelenko, Y., ; Mourzina, Y., ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Näther, Niko, naether@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de The light-addressable potentiometric sensor for multi-ion sensing and imaging 2005 3 Methods. 37 (2005), H. 1 1046-2023 99 102 campus http://dx.doi.org/10.1016/j.ymeth.2005.05.020 Fachbereich Medizintechnik und Technomathematik OPUS4-1974 Wissenschaftlicher Artikel Yoshinobu, T., ; Ermelenko, Y., ; Mourzina, Y., ; Schöning, Michael Josef, schoening@fh-aachen.de; Iwasaki, H., ; Vlasov, Y., Multi-component analysis based on the light-addressable potentiometric sensor (LAPS) Wunstorf AMA Service 2003 3 Proceedings : 11th international conference Sensor 2003; 13 - 15 May 2003, Exhibition Centre Nuremberg, Germany Internationale Messe mit Kongress Sensor <11, 2003, Nürnberg> 141 144 Fachbereich Medizintechnik und Technomathematik OPUS4-1874 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Simonis, A., ; Iwasaki, H., ; Lüth, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Constant-current-mode LAPS (CLAPS) for the detection of penicillin 2001 3 Electroanalysis. 13 (2001), H. 8-9 1040-0397 733 736 campus http://www3.interscience.wiley.com/cgi-bin/abstract/82502248/ABSTRACT Fachbereich Medizintechnik und Technomathematik OPUS4-1812 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Lüth, H., ; Iwasaki, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Alternative sensor materials for light-addressable potentiometric sensors 2001 4 Sensors and Actuators B. 76 (2001), H. 1-3 0925-4005 388 392 campus http://dx.doi.org/10.1016/S0925-4005(01)00646-3 Fachbereich Medizintechnik und Technomathematik OPUS4-1688 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Ismail, Md.A.B., ; Iwasaki, H., ; Lüth, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Chemical imaging sensor and its application to biological systems Amsterdam [u.a.] Elsevier [u.a.] 2001 385 S. : Ill., graph. Darst. Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz 0-08-044014-2 259 263 Fachbereich Medizintechnik und Technomathematik OPUS4-10996 Wissenschaftlicher Artikel Yang, Peng-Fei, ; Kriechbaumer, Andreas, ; Albracht, Kirsten, Albracht@fh-aachen.de; Sanno, Maximilian, ; Ganse, Bergita, ; Koy, Timmo, ; Shang, Peng, ; brüggemann, Gert-Peter, ; Müller, Lars Peter, ; Rittweger, Jörn, A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans Singapore Elsevier 2014 0 Journal of Orthopaedic Translation 2 4 238 238 10.1016/j.jot.2014.07.078 https://www.sciencedirect.com/science/article/pii/S2214031X14001582?via%3Dihub Fachbereich Medizintechnik und Technomathematik OPUS4-7692 Wissenschaftlicher Artikel Wu, Chunsheng, C.Wu@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules. Amsterdam Elsevier 2016 6 Sensors and Actuators B: Chemical 229 506 512 10.1016/j.snb.2016.02.004 bezahl https://doi.org/10.1016/j.snb.2016.02.004 Fachbereich Medizintechnik und Technomathematik OPUS4-7046 Wissenschaftlicher Artikel Wu, Chunsheng, C.Wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer 2015 7 Nanoscale 7 6143 6150 10.1039/C4NR07225A Fachbereich Medizintechnik und Technomathematik OPUS4-6444 Wissenschaftlicher Artikel Wu, Chunsheng, c.wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge. Weinheim Wiley-VCH 2014 5 Physica status solidi A : Applications and materials science 211 6 1423 1428 10.1002/pssa.201330442 campus https://doi.org/10.1002/pssa.201330442 Fachbereich Medizintechnik und Technomathematik OPUS4-4824 Wissenschaftlicher Artikel Wiescher, A., ; Kotliar, Konstantin, kotliar@fh-aachen.de; Neuhann, T., ; Lanzl, Ines M., Rasch progrediente Visusminderung beider Augen bei einem jungen Patienten - 2010 3 Der Ophthalmologe 105 1433-0423 4 389 392 campus http://dx.doi.org/10.1007/s00347-007-1586-x Fachbereich Medizintechnik und Technomathematik OPUS4-9548 Wissenschaftlicher Artikel Wert, Stefan, ; Iken, Heiko, iken@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Matysik, Frank-Michael, Development of a temperature-pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating. Weinheim Wiley-VCH 2021 Electroanalysis Early View 10.1002/elan.202100089 weltweit https://doi.org/10.1002/elan.202100089 Fachbereich Medizintechnik und Technomathematik OPUS4-5315 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Frequency behaviour of light-addressable potentiometric sensors Weinheim Wiley-VCH 2013 7 Physica Status Solidi (A). Vol. 210 (2013), iss. 5 884 891 campus http://onlinelibrary.wiley.com/doi/10.1002/pssa.201200929/pdf Fachbereich Medizintechnik und Technomathematik OPUS4-2079 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display. Amsterdam Elsevier 2012 4 Sensors and Actuators B: Chemical 175 Part of special issue "Selected Papers presented at Eurosensors XXV" 118 122 10.1016/j.snb.2011.12.102 campus https://doi.org/10.1016/j.snb.2011.12.102 Fachbereich Medizintechnik und Technomathematik OPUS4-4616 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up Amsterdam Elsevier 2011 3 Procedia Engineering. 25 (2011) 1877-7058 EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece 346 349 campus http://dx.doi.org/10.1016/j.proeng.2011.12.085 Fachbereich Medizintechnik und Technomathematik OPUS4-4960 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Takenaga, Shoko, ; Taki, Hidenori, ; Sawada, Kazuaki, ; Schöning, Michael Josef, schoening@fh-aachen.de Comparison of label-free ACh-imaging sensors based on CCD and LAPS Amsterdam Elsevier 2013 7 Sensors and Actuators B: Chemical (2012) 177 0925-4005 745 752 campus http://dx.doi.org/10.1016/j.snb.2012.11.012 Fachbereich Medizintechnik und Technomathematik OPUS4-4382 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Spelthahn, H., ; Schöning, Michael Josef, schoening@fh-aachen.de; Krumbe, C., ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, T., ; Keusgen, M., Neue Ansteuerungselektronik für LAPS-basierte Biosensoren zur gleichzeitig ortsaufgelösten Messung der pH-Konzentration Berlin VDE Verlag 2010 1 CD-ROM Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA) 978-3-8007-3260-9 Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik 109 114 Fachbereich Medizintechnik und Technomathematik OPUS4-4273 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Schusser, Sebastian, schusser@fh-aachen.de; Spalthahn, Heiko, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de Field-programmable gate array based controller for multi spot light-addressable potentiometric sensors with integrated signal correction mode Amsterdam Elsevier 2011 4 Electrochimica Acta. 56 (2011), H. 26 0013-4686 9656 9660 campus http://dx.doi.org/10.1016/j.electacta.2011.03.012 Fachbereich Medizintechnik und Technomathematik OPUS4-8147 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor Amsterdam Elsevier 2017 4 Sensor and Actuators B: Chemical 248 961 965 10.1016/j.snb.2017.02.057 Fachbereich Medizintechnik und Technomathematik OPUS4-4363 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Krumbe, Christoph, ; Schumacher, Katharina, ; Groebel, Simone, groebel@fh-aachen.de; Spelthahn, Heiko, spelthahn@fh-aachen.de; Stellberg, Michael, stellberg@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Selmer, Thorsten, selmer@fh-aachen.de; Keusgen, Michael, ; Baumann, Marcus, rektor@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor Weinheim Wiley 2011 4 Physica status solidi (a) : applications and material science. 208 (2011), H. 6 1862-6319 1340 1344 campus http://dx.doi.org/10.1002/pssa.201001141 Fachbereich Chemie und Biotechnologie OPUS4-4391 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Groebel, Simone, groebel@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Selmer, Thorsten, selmer@fh-aachen.de; Baumann, Marcus, rektor@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Überwachung der metabolischen Aktivität von Mikroorganismen zur Kontrolle des biologischen Prozesses im Biogasfermenter Düsseldorf VDI-Verl. 2011 292 S. : Ill., graph. Darst., Kt. Biogas 2011 : Energieträger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt 978-3-18-092121-1 Gesellschaft Energie und Umwelt ; Fachtagung Biogas ; (6 : ; 2011.06.08-09 : ; Braunschweig) ; VDI-Berichte ; 2121 285 286 Fachbereich Chemie und Biotechnologie OPUS4-3982 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Groebel, Simone, groebel@fh-aachen.de; Schuhmacher, K., ; Spelthahn, Heiko, spelthahn@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Selmer, Thorsten, selmer@fh-aachen.de; Baumann, Marcus, rektor@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Bestimmung der metabolischen Aktivität von Mikroorganismen während des Biogasbildungsprozesses Dresden TUDpress 2009 351 S. : Ill., graph. Darst. 9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.] 978-3-941298-44-6 Dresdner Sensor-Symposium ; (9, 2009, Dresden) 201 204 Fachbereich Chemie und Biotechnologie OPUS4-10977 Wissenschaftlicher Artikel Werkhausen, Amelie, ; Willwacher, Steffen, ; Albracht, Kirsten, Albracht@fh-aachen.de Medial gastrocnemius muscle fascicles shorten throughout stance during sprint acceleration The compliant nature of distal limb muscle-tendon units is traditionally considered suboptimal in explosive movements when positive joint work is required. However, during accelerative running, ankle joint net mechanical work is positive. Therefore, this study aims to investigate how plantar flexor muscle-tendon behavior is modulated during fast accelerations. Eleven female sprinters performed maximum sprint accelerations from starting blocks, while gastrocnemius muscle fascicle lengths were estimated using ultrasonography. We combined motion analysis and ground reaction force measurements to assess lower limb joint kinematics and kinetics, and to estimate gastrocnemius muscle-tendon unit length during the first two acceleration steps. Outcome variables were resampled to the stance phase and averaged across three to five trials. Relevant scalars were extracted and analyzed using one-sample and two-sample t-tests, and vector trajectories were compared using statistical parametric mapping. We found that an uncoupling of muscle fascicle behavior from muscle-tendon unit behavior is effectively used to produce net positive mechanical work at the joint during maximum sprint acceleration. Muscle fascicles shortened throughout the first and second steps, while shortening occurred earlier during the first step, where negative joint work was lower compared with the second step. Elastic strain energy may be stored during dorsiflexion after touchdown since fascicles did not lengthen at the same time to dissipate energy. Thus, net positive work generation is accommodated by the reuse of elastic strain energy along with positive gastrocnemius fascicle work. Our results show a mechanism of how muscles with high in-series compliance can contribute to net positive joint work. Oxford Wiley-Blackwell 2021 9 Scandinavian Journal of Medicine & Science in Sports 31 7 1471 1480 10.1111/sms.13956 weltweit https://doi.org/10.1111/sms.13956 Fachbereich Medizintechnik und Technomathematik OPUS4-10989 Wissenschaftlicher Artikel Werkhausen, Amelie, ; Cronin, Neil J., ; Albracht, Kirsten, Albracht@fh-aachen.de; Paulsen, Gøran, ; Larsen, Askild V., ; Bojsen-Møller, Jens, ; Seynnes, Olivier R., Training-induced increase in Achilles tendon stiffness affects tendon strain pattern during running Background During the stance phase of running, the elasticity of the Achilles tendon enables the utilisation of elastic energy and allows beneficial contractile conditions for the triceps surae muscles. However, the effect of changes in tendon mechanical properties induced by chronic loading is still poorly understood. We tested the hypothesis that a training-induced increase in Achilles tendon stiffness would result in reduced tendon strain during the stance phase of running, which would reduce fascicle strains in the triceps surae muscles, particularly in the mono-articular soleus. Methods Eleven subjects were assigned to a training group performing isometric singleleg plantarflexion contractions three times per week for ten weeks, and another ten subjects formed a control group. Before and after the training period, Achilles tendon stiffness was estimated, and muscle-tendon mechanics were assessed during running at preferred speed using ultrasonography, kinematics and kinetics. Results Achilles tendon stiffness increased by 18% (P <0:01) in the training group, but the associated reduction in strain seen during isometric contractions was not statistically significant. Tendon elongation during the stance phase of running was similar after training, but tendon recoil was reduced by 30% (P <0:01), while estimated tendon force remained unchanged. Neither gastrocnemius medialis nor soleus fascicle shortening during stance was affected by training. Discussion These results show that a training-induced increase in Achilles tendon stiffness altered tendon behaviour during running. Despite training-induced changes in tendon mechanical properties and recoil behaviour, the data suggest that fascicle shortening patterns were preserved for the running speed that we examined. The asymmetrical changes in tendon strain patterns supports the notion that simple inseries models do not fully explain the mechanical output of the muscle-tendon unit during a complex task like running. London Peer 2019 18 Seiten PeerJ 10.7717/peerj.6764 https://doi.org/10.7717/peerj.6764 Fachbereich Medizintechnik und Technomathematik OPUS4-9007 Wissenschaftlicher Artikel Werkhausen, Amelie, ; Cronin, Neil J., ; Albracht, Kirsten, albracht@fh-aachen.de; Bojsen-Møller, Jens, ; Seynnes, Olivier R., Distinct muscle-tendon interaction during running at different speeds and in different loading conditions 2019 7 Journal of Applied Physiology 127 1 246 253 10.1152/japplphysiol.00710.2018 campus https://doi.org/10.1152/japplphysiol.00710.2018 Fachbereich Medizintechnik und Technomathematik OPUS4-10994 Wissenschaftlicher Artikel Werkhausen, Amelie, ; Albracht, Kirsten, Albracht@fh-aachen.de; Cronin, Neil J, ; Paulsen, Gøran, ; Bojsen-Møller, Jens, ; Seynnes, Olivier R, Effect of training-induced changes in achilles tendon stiffness on muscle-tendon behavior during landing During rapid deceleration of the body, tendons buffer part of the elongation of the muscle-tendon unit (MTU), enabling safe energy dissipation via eccentric muscle contraction. Yet, the influence of changes in tendon stiffness within the physiological range upon these lengthening contractions is unknown. This study aimed to examine the effect of training-induced stiffening of the Achilles tendon on triceps surae muscle-tendon behavior during a landing task. Twenty-one male subjects were assigned to either a 10-week resistance-training program consisting of single-leg isometric plantarflexion (n = 11) or to a non-training control group (n = 10). Before and after the training period, plantarflexion force, peak Achilles tendon strain and stiffness were measured during isometric contractions, using a combination of dynamometry, ultrasound and kinematics data. Additionally, testing included a step-landing task, during which joint mechanics and lengths of gastrocnemius and soleus fascicles, Achilles tendon, and MTU were determined using synchronized ultrasound, kinematics and kinetics data collection. After training, plantarflexion strength and Achilles tendon stiffness increased (15 and 18%, respectively), and tendon strain during landing remained similar. Likewise, lengthening and negative work produced by the gastrocnemius MTU did not change detectably. However, in the training group, gastrocnemius fascicle length was offset (8%) to a longer length at touch down and, surprisingly, fascicle lengthening and velocity were reduced by 27 and 21%, respectively. These changes were not observed for soleus fascicles when accounting for variation in task execution between tests. These results indicate that a training-induced increase in tendon stiffness does not noticeably affect the buffering action of the tendon when the MTU is rapidly stretched. Reductions in gastrocnemius fascicle lengthening and lengthening velocity during landing occurred independently from tendon strain. Future studies are required to provide insight into the mechanisms underpinning these observations and their influence on energy dissipation. Lausanne Frontiers Research Foundation 2018 11 Seiten Frontiers in physiology 9 10.3389/fphys.2018.00794 https://pubmed.ncbi.nlm.nih.gov/29997526/ Fachbereich Medizintechnik und Technomathematik OPUS4-9792 Wissenschaftlicher Artikel Werfel, Stanislas, ; Günthner, Roman, ; Hapfelmeier, Alexander, ; Hanssen, Henner, ; Kotliar, Konstantin, Kotliar@fh-aachen.de; Heemann, Uwe, ; Schmaderer, Christoph, Guzik, Tomasz J. Identification of cardiovascular high-risk groups from dynamic retinal vessel signals using untargeted machine learning Dynamic retinal vessel analysis (DVA) provides a non-invasive way to assess microvascular function in patients and potentially to improve predictions of individual cardiovascular (CV) risk. The aim of our study was to use untargeted machine learning on DVA in order to improve CV mortality prediction and identify corresponding response alterations. Oxford Oxford University Press 2022 9 Cardiovascular Research 118 2 612 621 10.1093/cvr/cvab040 weltweit https://doi.org/10.1093/cvr/cvab040 Fachbereich Medizintechnik und Technomathematik OPUS4-9238 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick H., ; Wagner, Torsten, torsten.wagner@fh-aachen.de Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor-electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types. Basel MDPI 2020 21 Sensors 20 Artikel-Nummer 1680 1 22 10.3390/s20061680 weltweit https://doi.org/10.3390/s20061680 Fachbereich Medizintechnik und Technomathematik OPUS4-8428 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Scheja, Sabrina, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, ; Wagner, Torsten, torsten.wagner@fh-aachen.de Electrochemical Evaluation of Light-Addressable Electrodes Based on TiO2 for the Integration in Lab-on-Chip Systems In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol-gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated. Weinheim Wiley-VCH 2018 physica status solidi a : applications and materials sciences 215 15 Article number 1800150 10.1002/pssa.201800150 campus https://doi.org/10.1002/pssa.201800150 Fachbereich Medizintechnik und Technomathematik OPUS4-9958 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Nagamine Komesu, Cindy A., ; Wagner, Patrick H., ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin. Weinheim Wiley-VCH 2021 4 Electrochemical Science Advances 2 Corresponding auhtor: Michael J. Schöning 4 1 5 10.1002/elsa.202100131 weltweit https://doi.org/10.1002/elsa.202100131 Fachbereich Medizintechnik und Technomathematik OPUS4-7749 Wissenschaftlicher Artikel Wegmann, Kilian, ; Hackl, Michael, ; Staat, Manfred, m.staat@fh-aachen.de; Mayer, Katharina, ; Müller, Lars-Peter, Double plate osteosynthesis of proximal ulna fractures: biomechanical and clinical results While plate fixation of proximal ulna fractures might lead to superior clinical results compared to tension band wiring, regular plates represent an established risk factor for wound complications. The olecranon double plates (Medartis, Basel, CH) might decrease complications related to the osteosynthesis because of their low profile and better anatomical fit. This study aimed to evaluate the biomechanical performance and clinical results of the olecranon double plates. Berlin Springer 2016 1 Knee surgery, sports traumatology, arthroscopy Volume 24 Supplement 1 58 59 10.1007/s00167-016-4079-0 campus http://doi.org/10.1007/s00167-016-4079-0 Fachbereich Medizintechnik und Technomathematik OPUS4-5091 Wissenschaftlicher Artikel Wedrowski, M., ; Bruyndonckx, P., ; Tavernier, S., ; Zhi, L., ; Dang, J., ; Mendes, P. R., ; Perez, J. M., ; Ziemons, Karl, k.ziemons@fh-aachen.de Robustness of neural networks algorithm for gamma detection in monolithic block detector, positron emission tomography The monolithic scintillator block approach for gamma detection in the Positron Emission Tomography (PET) avoids estimating Depth of Interaction (DOI), reduces dead zones in detector and diminishes costs of detector production. Neural Networks (NN) are very efficient to determine the entrance point of a gamma incident on a scintillator block. This paper presents results on the robustness of the spatial resolution as a function of the random fraction in the data, temperature and HV fluctuations. This is important when implementing the method in a real scanner. Measurements were done with two Hamamatsu S8550 APD arrays, glued on a 20 × 20 × 10 mm3 monolithic LSO crystal block. 2009 3 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC) 1082-3654 2625 2628 campus http://dx.doi.org/10.1109/NSSMIC.2009.5402007 Fachbereich Medizintechnik und Technomathematik OPUS4-5045 Wissenschaftlicher Artikel Weckesser, Matthias, ; Hufnagel, Andreas, ; Ziemons, Karl, k.ziemons@fh-aachen.de; Grießmeier, Martin, ; Sonnenberg, Frank, ; Hackländer, Thomas, ; Langen, Karl-J., ; Holschbach, Markus, ; Elger, Christian E., ; Müller-Gärtner, Hans-W., Effect of partial volume correction on muscarinic cholinergic receptor imaging with single-photon emission tomography in patients with temporal lobe epilepsy Animal experiments and preliminary results in humans have indicated alterations of hippocampal muscarinic acetylcholine receptors (mAChR) in temporal lobe epilepsy. Patients with temporal lobe epilepsy often present with a reduction in hippocampal volume. The aim of this study was to investigate the influence of hippocampal atrophy on the quantification of mAChR with single photon emission tomography (SPET) in patients with temporal lobe epilepsy. Cerebral uptake of the muscarinic cholinergic antagonist [123I]4-iododexetimide (IDex) was investigated by SPET in patients suffering from temporal lobe epilepsy of unilateral (n=6) or predominantly unilateral (n=1) onset. Regions of interest were drawn on co-registered magnetic resonance images. Hippocampal volume was determined in these regions and was used to correct the SPET results for partial volume effects. A ratio of hippocampal IDex binding on the affected side to that on the unaffected side was used to detect changes in muscarinic cholinergic receptor density. Before partial volume correction a decrease in hippocampal IDex binding on the focus side was found in each patient. After partial volume no convincing differences remained. Our results indicate that the reduction in hippocampal IDex binding in patients with epilepsy is due to a decrease in hippocampal volume rather than to a decrease in receptor concentration. 1997 5 European Journal of Nuclear Medicine 24 1619-7089 9 1156 1161 campus http://dx.doi.org/10.1007/BF01254249 Fachbereich Medizintechnik und Technomathematik OPUS4-5048 Wissenschaftlicher Artikel Weckesser, Martin, ; Grießmeier, Martin, ; Schmidt, Daniela, ; Sonnenberg, Frank, ; Ziemons, Karl, k.ziemons@fh-aachen.de; Kemna, Lars, ; Holschbach, Marcus, ; Langen, Karl-J., ; Müller-Gärtner, Hans-W., Iodine-123 α-methyl tyrosine single-photon emission tomography of cerebral gliomas: standardised evaluation of tumour uptake and extent Single-photon emission tomography (SPET) with the amino acid analogue l-3-[123I]iodo-α-methyl tyrosine (IMT) is helpful in the diagnosis and monitoring of cerebral gliomas. Radiolabelled amino acids seem to reflect tumour infiltration more specifically than conventional methods like magnetic resonance imaging and computed tomography. Automatic tumour delineation based on maximal tumour uptake may cause an overestimation of mean tumour uptake and an underestimation of tumour extension in tumours with circumscribed peaks. The aim of this study was to develop a program for tumour delineation and calculation of mean tumour uptake which takes into account the mean background activity and is thus optimised to the problem of tumour definition in IMT SPET. Using the frequency distribution of pixel intensities of the tomograms a program was developed which automatically detects a reference brain region and draws an isocontour region around the tumour taking into account mean brain radioactivity. Tumour area and tumour/brain ratios were calculated. A three-compartment phantom was simulated to test the program. The program was applied to IMT SPET studies of 20 patients with cerebral gliomas and was compared to the results of manual analysis by three different investigators. Activity ratios and chamber extension of the phantom were correctly calculated by the automatic analysis. A method based on image maxima alone failed to determine chamber extension correctly. Manual region of interest analysis in patient studies resulted in a mean inter-observer standard deviation of 8.7%±6.1% (range 2.7%-25.0%). The mean value of the results of the manual analysis showed a significant correlation to the results of the automatic analysis (r = 0.91, P<0.0001 for the uptake ratio; r = 0.87, P<0.0001 for the tumour area). We conclude that the algorithm proposed simplifies the calculation of uptake ratios and may be used for observer-independent evaluation of IMT SPET studies. Three-dimensional tumour recognition and transfer to co-registered morphological images based on this program may be useful for the planning of surgical and radiation treatment. 1998 6 European Journal of Nuclear Medicine 25 1619-7089 2 150 156 campus http://dx.doi.org/10.1007/s002590050208 Fachbereich Medizintechnik und Technomathematik OPUS4-3623 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Schulte, A., ; Lauterbach, Gerhard, ; Südkamp, Michael [u.a.], Studienüberblick zu transienten Druckexkursionen bei Membranoxygenatoren / A. Schulte, G. Lauterbach, M. Südkamp, H.-J. Weber 1999 2 Kardiotechnik. 8 (1999), H. 1 0941-2670 14 16 Fachbereich Medizintechnik und Technomathematik OPUS4-4253 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Schmitt, W., ; Jahn, D., ; Euringer, H., Ein Versuch zur theoretischen Temperaturermittlung im Schneidbereich bei Bohrungen in kortikalem Knochen - An Experiment to Calculate the Theoretical Temperature at the Drill - Cortical Bone Interface / Schmitt, W. ; Weber, H. J. ; Jahn, D. ; Euringer, H. 1989 3 Biomedizinische Technik/Biomedical Engineering. 34 (1989), H. 3 0013-5585 in der Bereichsbibliothek Jülich gedruckt vorhanden 53 56 bezahl http://www.reference-global.com/doi/pdf/10.1515/bmte.1989.34.3.53 Fachbereich Medizintechnik und Technomathematik OPUS4-4252 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Schmitt, W., ; Jahn, D., Thermische Untersuchungen beim Bohren in kortikalem Knochen unter Verwendung verschiedener Kühlsysteme / Schmitt, W. ; Weber, H. J. ; Jahn, D. 1988 3 Deutsche zahnärztliche Zeitschrift : DZZ. 43 (1988), H. 7 0012-1029 802 805 Fachbereich Medizintechnik und Technomathematik OPUS4-3613 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Mo, Xiumei, ; Ramakrishna, S., PCL-PGLA composite tubular scaffold preparation and biocompatibility investigation / X. Mo, H.-J. Weber, S. Ramakrishna - 2006 9 The International journal of artificial organs. 29 (2006), H. 8 790 799 Fachbereich Medizintechnik und Technomathematik OPUS4-3612 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Mo, Xiumei, ; Chen, Zonggang, Electrospun nanofibers of collagen-chitosan and P(LLA-CL) for tissue engineering / Mo Xiumei, Chen Zonggang, Hans J. Weber - 2007 3 Frontiers of materials science in China. 1 (2007), H. 1 1673-7377 20 23 bezahl http://dx.doi.org/10.1007/s11706-007-0004-2 Fachbereich Medizintechnik und Technomathematik OPUS4-3619 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Mo, Xiumei, Electrospinning P(LLA-CL) nanofiber: a tubular scaffold fabrication with circumferential alignment / Xiumei Mo, Hans-Joachim Weber Weinheim Wiley-VCH 2004 443 S.: Ill., graph. Darst. Contributions from 6th Austrian Polymer Meeting : Vienna, Austria, September 15 - 17, 2003 / Symposium ed.: W. H. Binder Österreichische Polymertage <6, 2003, Wien>. - (Macromolecular symposia ; 217,1) 413 416 campus http://www3.interscience.wiley.com/cgi-bin/fulltext/109746926/PDFSTART Fachbereich Medizintechnik und Technomathematik OPUS4-4254 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Laco, Filip, ; Kun, Ma, ; Ramakrishna, S., The dose effect of human bone marrow-derived mesenchymal stem cells on epidermal development in organotypic co-culture / Laco, Filip ; Kun, Ma ; Weber, Hans Joachim ; Ramakrishna, S. ; Chan, Casey K. 2009 10 Journal of Dermatological Science. 55 (2009), H. 3 0923-1811 150 160 campus http://dx.doi.org/10.1016/j.jdermsci.2009.05.009 Fachbereich Medizintechnik und Technomathematik OPUS4-3622 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Hekmat, Khosro, ; Kanani, Reza, ; Ahmadpour, R. [u.a.], Haben Mobiltelefone einen negativen Einfluss auf moderne Herzschrittmacher? / K. Hekmat, R. Kanani, R. Ahmadpour, G. Lauterbach, M. Südkamp, H.-J. Weber, E. R. de Vivie 2002 2 Kardiotechnik. 11 (2002), H. 2 0941-2670 45 47 Fachbereich Medizintechnik und Technomathematik OPUS4-4290 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Hekmat, K., ; Zimmermann, T., ; Kampe, S., Impact of tranexamic acid vs. aprotinin on blood loss and transfusion requirements after cardiopulmonary bypass: a prospective, randomised, double-blind trial / Hekmat, K. ; Zimmermann, T. ; Kampe, S. ; Kasper, S. M. ; Weber, H. J. ; Geissler, H. J. ; Meh 2004 5 Current Medical Research and Opinion. 20 (2004), H. 1 0300-7995 121 126 campus http://dx.doi.org/10.1185/030079903125002658 Fachbereich Medizintechnik und Technomathematik OPUS4-4267 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de; Bhuju, S., ; Chandra, S., ; Mo, X., Fabrication of biodegradable nanofibers for tubular scaffolds in regenerative medicine / Weber, H.-J. ; Bhuju, S. ; Chandra, S. ; Mo, X. 2004 1 Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2, Teil 2 1016 1017 Fachbereich Medizintechnik und Technomathematik OPUS4-3856 Wissenschaftlicher Artikel Weber, Hans-Joachim, weber@fh-aachen.de Verbundforschungsprojekt Multimediale 3D-Visualisierung der Herzmuskelerregung Köln Forschungverbund Multimedia an Fachhochschulen 2001 145 S. : Ill., graph. Darst. Intelligente, innovative Produktentwicklung für die industrielle Praxis. Stenzel, Horst [Hrsg.] Forschungsverbund Multimedia an Fachhochschulen in Nordrhein-Westfalen 99 112 weltweit http://www2.gm.fh-koeln.de/%7Ehstl/Dokumente/Java-Framework-Abschluss.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-7293 Wissenschaftlicher Artikel Warmer, Johannes, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de; Kaul, Peter, Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors Weinheim Wiley-VCH 2015 9 Physica status solidi (a) 212 6 1289 1298 10.1002/pssa.201431882 campus https://doi.org/10.1002/pssa.201431882 Fachbereich Medizintechnik und Technomathematik OPUS4-4312 Wissenschaftlicher Artikel Warerkar, Shashikant, ; Schmitz, Stefan, ; Göttsche, Joachim, goettsche@sij.fh-aachen.de; Hoffschmidt, Bernhard, hoffschmidt@sij.fh-aachen.de; Reißel, Martin, reissel@fh-aachen.de; Tamme, Rainer, Air-Sand Heat Exchanger for High-Temperature Storage New York ASME 2011 Journal of Solar Energy Engineering. 133 (2011), H. 2 0199-6231 7 pages 021010 campus http://dx.doi.org/10.1115/1.4003583 Fachbereich Medizintechnik und Technomathematik OPUS4-1789 Wissenschaftlicher Artikel Wang, J., ; Krause, R., ; Block, K., ; Musameh, M., ; Mulchandani, A., ; Schöning, Michael Josef, schoening@fh-aachen.de Flow injection amperometric detection of OP nerve agents based on organophosphorus-hydrolase biosensor detector 2003 5 Biosensors & Bioelectronics. 18 (2003), H. 2-3 0956-5663 255 260 campus http://dx.doi.org/10.1016/S0956-5663(02)00178-1 Fachbereich Medizintechnik und Technomathematik OPUS4-9550 Wissenschaftlicher Artikel Waldvogel, Janice, ; Ritzmann, Ramona, ; Freyler, Kathrin, ; Helm, Michael, ; Monti, Elena, ; Albracht, Kirsten, albracht@fh-aachen.de; Stäudle, Benjamin, ; Gollhofer, Albert, ; Narici, Marco, The Anticipation of Gravity in Human Ballistic Movement Stretch-shortening type actions are characterized by lengthening of the pre-activated muscle-tendon unit (MTU) in the eccentric phase immediately followed by muscle shortening. Under 1 g, pre-activity before and muscle activity after ground contact, scale muscle stiffness, which is crucial for the recoil properties of the MTU in the subsequent push-off. This study aimed to examine the neuro-mechanical coupling of the stretch-shortening cycle in response to gravity levels ranging from 0.1 to 2 g. During parabolic flights, 17 subjects performed drop jumps while electromyography (EMG) of the lower limb muscles was combined with ultrasound images of the gastrocnemius medialis, 2D kinematics and kinetics to depict changes in energy management and performance. Neuro-mechanical coupling in 1 g was characterized by high magnitudes of pre-activity and eccentric muscle activity allowing an isometric muscle behavior during ground contact. EMG during pre-activity and the concentric phase systematically increased from 0.1 to 1 g. Below 1 g the EMG in the eccentric phase was diminished, leading to muscle lengthening and reduced MTU stretches. Kinetic energy at take-off and performance were decreased compared to 1 g. Above 1 g, reduced EMG in the eccentric phase was accompanied by large MTU and muscle stretch, increased joint flexion amplitudes, energy loss and reduced performance. The energy outcome function established by linear mixed model reveals that the central nervous system regulates the extensor muscles phase- and load-specifically. In conclusion, neuro-mechanical coupling appears to be optimized in 1 g. Below 1 g, the energy outcome is compromised by reduced muscle stiffness. Above 1 g, loading progressively induces muscle lengthening, thus facilitating energy dissipation. Lausanne Frontiers 2021 Frontiers in Physiology 10.3389/fphys.2021.614060 weltweit https://doi.org/10.3389/fphys.2021.614060 Fachbereich Medizintechnik und Technomathematik OPUS4-10704 Wissenschaftlicher Artikel Waldvogel, Janice, ; Freyler, Kathrin, ; Helm, Michael, ; Monti, Elena, ; Stäudle, Benjamin, ; Gollhofer, Albert, ; Narici, Marco V., ; Ritzmann, Ramona, ; Albracht, Kirsten, Albracht@fh-aachen.de Changes in gravity affect neuromuscular control, biomechanics, and muscle-tendon mechanics in energy storage and dissipation tasks This study evaluates neuromechanical control and muscle-tendon interaction during energy storage and dissipation tasks in hypergravity. During parabolic flights, while 17 subjects performed drop jumps (DJs) and drop landings (DLs), electromyography (EMG) of the lower limb muscles was combined with in vivo fascicle dynamics of the gastrocnemius medialis, two-dimensional (2D) kinematics, and kinetics to measure and analyze changes in energy management. Comparisons were made between movement modalities executed in hypergravity (1.8 G) and gravity on ground (1 G). In 1.8 G, ankle dorsiflexion, knee joint flexion, and vertical center of mass (COM) displacement are lower in DJs than in DLs; within each movement modality, joint flexion amplitudes and COM displacement demonstrate higher values in 1.8 G than in 1 G. Concomitantly, negative peak ankle joint power, vertical ground reaction forces, and leg stiffness are similar between both movement modalities (1.8 G). In DJs, EMG activity in 1.8 G is lower during the COM deceleration phase than in 1 G, thus impairing quasi-isometric fascicle behavior. In DLs, EMG activity before and during the COM deceleration phase is higher, and fascicles are stretched less in 1.8 G than in 1 G. Compared with the situation in 1 G, highly task-specific neuromuscular activity is diminished in 1.8 G, resulting in fascicle lengthening in both movement modalities. Specifically, in DJs, a high magnitude of neuromuscular activity is impaired, resulting in altered energy storage. In contrast, in DLs, linear stiffening of the system due to higher neuromuscular activity combined with lower fascicle stretch enhances the buffering function of the tendon, and thus the capacity to safely dissipate energy. Bethesda, Md. American Physiological Society 2023 12 Journal of Applied Physiology 134 1 190 202 10.1152/japplphysiol.00279.2022 bezahl https://journals.physiology.org/doi/abs/10.1152/japplphysiol.00279.2022 Fachbereich Medizintechnik und Technomathematik OPUS4-1964 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, T., ; Rao, C., ; Otto, R., ; Schöning, Michael Josef, schoening@fh-aachen.de „All-in-one" solid-state device based on a lightaddressable potentiometric sensor platform Piscataway, NJ IEEE Operations Center 2005 3 Transducers '05 : the 13th International Conference on Solid-State Sensors, Actuators and Microsystems ; Seoul, Korea, [June 5 - 9, 2005] ; digest of technical papers / sponsored by Korean Sensors Society. Technical co-sponsors: IEEE Electron Devices Society 0-7803-83995-6 International Conference on Solid State Sensors, Actuators and Microsystems ; (13, 2005, Seoul) 1872 1875 Fachbereich Medizintechnik und Technomathematik OPUS4-4272 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-Ichiro, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging 2012 5 Sensors and Actuators B: Chemical. 170 (2012) 0925-4005 Eurosensors XXIV, 2010 34 39 campus http://dx.doi.org/10.1016/j.snb.2010.12.003 Fachbereich Medizintechnik und Technomathematik OPUS4-4368 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-Ichiro, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, A high-density multi-point LAPS set-up using a VCSEL array and FPGA control Amsterdam Elsevier 2011 4 Sensors and Actuators B: Chemical. 154 (2011), H. 2 1873-3077 EUROSENSORS XXIII 124 128 campus http://dx.doi.org/10.1016/j.snb.2010.03.009 Fachbereich Medizintechnik und Technomathematik OPUS4-4218 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Ackermann, Hans-Josef, h-j.ackermann@fh-aachen.de; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces 2010 5 Physica Status Solidi (A). 207 (2010), H. 4 1862-6300 Special Issue: Engineering of Functional Interfaces EnFI 2009 844 849 campus http://dx.doi.org/10.1002/pssa.200983320 Fachbereich Medizintechnik und Technomathematik OPUS4-3984 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, K., ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, T., A high-density multi-point LAPS set-up using a VCSEL array and FPGA control Amsterdam Elsevier 2009 3 Procedia Chemistry. 1 (2009), H. 1 1876-6196 Proceedings of the Eurosensors XXIII conference ; Eurosensors 23 1483 1486 campus http://dx.doi.org/10.1016/j.proche.2009.07.370 Fachbereich Medizintechnik und Technomathematik OPUS4-7800 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Vornholt, Wolfgang, ; Werner, Frederik, f.werner@fh-aachen.de; Yoshinobu, Tatsuo, ; Miyamoto, Ko-Ichiro, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution. 2016 5 Physics in medicine 2016 1 2 7 10.1016/j.phmed.2016.03.001 weltweit https://doi.org/10.1016/j.phmed.2016.03.001 Fachbereich Medizintechnik und Technomathematik OPUS4-4948 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Shigiahara, N., ; Miyamoto, K., ; Suzurikawa, J., ; Finger, F., ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, T., Light-addressable Potentiometric Sensors and Light-addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented. Amsterdam Elsevier 2012 3 Procedia Engineering Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" 47 890 893 10.1016/j.proeng.2012.09.290 campus https://doi.org/10.1016/j.proeng.2012.09.290 Fachbereich Medizintechnik und Technomathematik OPUS4-1756 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Yoshinobu, T., A handheld 16 channel pen-type LAPS as a platform for (bio-)electrochemical sensing 2004 1 Biomedizinische Technik. 49 (2004), H. 2 0932-4666 996 997 Fachbereich Medizintechnik und Technomathematik OPUS4-3443 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors (LAPS): recent trends and applications Amsterdam Elsevier 2007 LIV, 974 S. + 1 CD-ROM Electrochemical sensor analysis / edited by S. Alegret ... 978-0-444-53053-0 Wilson & Wilson's comprehensive analytical chemistry ; 49 87 128 Fachbereich Medizintechnik und Technomathematik OPUS4-1794 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Rao, C., ; Otto, R., ; Yoshinobu, T., ; Kloock, Joachim P., ; Schöning, Michael Josef, schoening@fh-aachen.de Chipkarten-basierter Multikanal lichtadressierbarer potentiometrischer Sensor für analytische Anwendungen in flüssigen Medien Dresden TUDpress 2005 313 S Neue Herausforderungen und Anwendungen in der Sensortechnik : 7. Dresdner Sensor-Symposium ; 12. - 14. Dezember 2005, Dresden / [Forschungsgesellschaft für Messtechnik, Sensorik und Medizintechnik e.V.]. Gerald Gerlach ... (Hg.) 3-938863-29-3 Dresdner Beiträge zur Sensorik ; 24 11 14 Fachbereich Medizintechnik und Technomathematik OPUS4-3053 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Rao, C., ; Kloock, Joachim P., kloock@fh-aachen.de; Yoshinobu, T., ; Otto, R., ; Keusgen, M., ; Schöning, Michael Josef, schoening@fh-aachen.de "LAPS Card"—A novel chip card-based light-addressable potentiometric sensor (LAPS) 2006 7 Sensors and Actuators B: Chemical. 118 (2006), H. 1-2 0925-4005 Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers 33 40 campus http://dx.doi.org/10.1016/j.snb.2006.04.019 Fachbereich Medizintechnik und Technomathematik OPUS4-3249 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Molina, Roberto, ; Yoshinobu, Tatsuo, ; Kloock, Joachim P., kloock@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Canzoneri, Michele, canzoneri@fh-aachen.de; Schnitzler, Thomas, schnitzler@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications 2007 6 Electrochimica Acta. 53 (2007), H. 2 0013-4686 305 311 campus http://dx.doi.org/10.1016/j.electacta.2007.04.006 Fachbereich Chemie und Biotechnologie OPUS4-3453 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Molina, R., ; Biselli, Manfred, biselli@fh-aachen.de; Canzoneri, Michele, canzoneri@fh-aachen.de; Schnitzler, Thomas, schnitzler@fh-aachen.de; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells Piscataway IEEE 2007 3 Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.) 1-4244-0841-5 Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon 1107 1110 campus http://dx.doi.org/10.1109/SENSOR.2007.4300328 Fachbereich Chemie und Biotechnologie OPUS4-4614 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Shigihara, Noriko, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor Amsterdam Elsevier 2011 3 Procedia Engineering. 25 (2011) 1877-7058 EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece 791 794 campus http://dx.doi.org/10.1016/j.proeng.2011.12.194 Fachbereich Medizintechnik und Technomathematik OPUS4-4384 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging 2010 3 Procedia Engineering. 5 (2010) 1877-7058 Eurosensor XXIV Conference 520 523 campus http://dx.doi.org/10.1016/j.proeng.2010.09.161 Fachbereich Medizintechnik und Technomathematik OPUS4-4484 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, K., ; Werner, Frederik, f.werner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, T., Flexible electrochemical imaging with "zoom-in" functionality by using a new type of light-addressable potentiometric sensor New York IEEE 2011 2 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011 2133 2135 campus http://dx.doi.org/10.1109/TRANSDUCERS.2011.5969294 Fachbereich Medizintechnik und Technomathematik OPUS4-6849 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, K., ; Werner, Frederik, f.werner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, T., Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) Stevenson Ranch, Calif. American Scientific Publishers 2011 3 9 2 812 815 10.1166/sl.2011.1620 bezahl Fachbereich Medizintechnik und Technomathematik