Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-8976 Wissenschaftlicher Artikel Özsoylu, Dua, ; Kizildag, Sefa, dua.oezsoylu@alumni.fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Effect of plasma treatment on the sensor properties of a light-addressable potentiometric sensor (LAPS) A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment. Weinheim Wiley 2019 8 Seiten physica status solidi a : applications and materials sciences 216 Corresponding author: Torsten Wagner 20 10.1002/pssa.201900259 weltweit https://doi.org/10.1002/pssa.201900259 Fachbereich Medizintechnik und Technomathematik OPUS4-9332 Wissenschaftlicher Artikel Özsoylu, Dua, oezsoylu@fh-aachen.de; Kizildag, Sefa, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS) Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images. Amsterdam Elsevier 2020 8 Physics in Medicine 10 100030 10.1016/j.phmed.2020.100030 weltweit https://doi.org/10.1016/j.phmed.2020.100030 Fachbereich Medizintechnik und Technomathematik OPUS4-8948 Konferenzveröffentlichung Zingsheim, Jonas, ; Grimmer, Timo, ; Ortner, Marion, ; Schmaderer, Christoph, ; Hauser, Christine, ; Kotliar, Konstantin, kotliar@fh-aachen.de Staat, Manfred; Erni, Daniel Recognition of subjects with mild cognitive impairment (MCI) by the use of retinal arterial vessels. Duisburg Universität Duisburg-Essen 2019 1 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH Aachen 978-3-940402-22-6 36 37 10.17185/duepublico/48750 weltweit https://doi.org/10.17185/duepublico/48750 Fachbereich Medizintechnik und Technomathematik OPUS4-5038 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Kleines, H., ; Erken, I., ; Knoben, J., ; Zwoll, K., Lehmann, Thomas IME-DV Projekt: M-FIRBe, Multi-Modality Functional Imaging for Brain Research Aachen Verl. der. Augustinus-Buchh. 1997 3 Bildverarbeitung für die Medizin : Algorithmen - Systeme - Anwendungen 3-86073-519-5 Proceedings des Aachener Workshops am 8. u. 9. November 1996 ; WG_005 Arbeitsgruppenvorstellungen 363 366 Fachbereich Medizintechnik und Technomathematik OPUS4-5032 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Herzog, H., ; Feinendegen, L. E., Iterative image reconstruction with weighted pixel contribution to projection element 1990 0 European Journal of Nuclear Medicine 16 1619-7089 Abstracts of the European Association of Nuclear Medicine Congress ; V52 7 403 403 campus http://dx.doi.org/10.1007/BF02266927 Fachbereich Medizintechnik und Technomathematik OPUS4-5035 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Herzog, H., ; Bosetti, P., ; Feinendegen, L. E., Iterative image reconstruction with weighted pixel contribution to projection elements 1992 0 European Journal of Nuclear Medicine 19 1619-7089 Abstracts of the European Association of Nuclear Medicine Congress 23-26 August 1992 Lisboa, Portugal ; V143-2 8 588 588 campus http://dx.doi.org/10.1007/BF00596386 Fachbereich Medizintechnik und Technomathematik OPUS4-5068 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Heinrichs, U., ; Streun, M., ; Pietrzyk, U., Validation of GEANT3 simulation studies with a dual-head PMT ClearPET™ prototype The ClearPET™ project is proposed by working groups of the Crystal Clear Collaboration (CCC) to develop a 2nd generation high performance small animal positron emission tomograph (PET). High sensitivity and high spatial resolution is foreseen for the ClearPET™ camera by using a phoswich arrangement combining mixed lutetium yttrium aluminum perovskite (LuYAP:Ce) and lutetium oxyorthosilicate (LSO) scintillating crystals. Design optimizations for the first photomultiplier tube (PMT) based ClearPET camera are done with a Monte-Carlo simulation package implemented on GEANT3 (CERN, Geneva, Switzerland). A dual-head prototype has been built to test the frontend electronics and was used to validate the implementation of the GEANT3 simulation tool. Multiple simulations were performed following the experimental protocols to measure the intrinsic resolution and the sensitivity profile in axial and radial direction. Including a mean energy resolution of about 27.0% the simulated intrinsic resolution is about (1.41±0.11)mm compared to the measured of (1.48±0.06)mm. The simulated sensitivity profiles show a mean square deviation of 12.6% in axial direction and 3.6% in radial direction. Satisfactorily these results are representative for all designs and confirm the scanner geometry. 2004 3 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 5 3053 3056 campus http://dx.doi.org/10.1109/NSSMIC.2003.1352542 Fachbereich Medizintechnik und Technomathematik OPUS4-5085 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Bruyndonckx, P., ; Perez, J. M., ; Pietrzyk, U., ; Rato, P., ; Tavernier, S., Beyond ClearPET: Next Aims The CRYSTAL CLEAR collaboration, in short CCC, is a consortium of 12 academic institutions, mainly from Europe, joining efforts in the area of developing instrumentation for nuclear medicine and medical imaging. In the framework of the CCC a high performance small animal PET system, called ClearPET, was developed by using new technologies in electronics and crystals in a phoswich arrangement combining two types of lutetium- based scintillator materials: LSO:Ce and LuYAP:Ce. Our next aim will be the development of hybrid image systems. Hybrid MR-PET imaging has many unique advantages for brain research. This has sparked a new research line within CCC for the development of novel MR-PET compatible technologies. MRI is not as sensitive as PET but PET has poorer spatial resolution than MRI. Two major advantages of PET are sensitivity and its ability to acquire metabolic information. To assess these innovations, the development of a 9.4T hybrid animal MR-PET scanner is proposed based on an existing 9.4T MR scanner that will be adapted to enable simultaneous acquisition of MR and PET data using cutting- edge technology for both MR and PET. 2008 3 5th IEEE International Symposium on Biomedical Imaging: From Nano to Macro Symposium Proceedings ISBI 2008 978-1-4244-2003-2 1421 1424 campus http://dx.doi.org/10.1109/ISBI.2008.4541273 Fachbereich Medizintechnik und Technomathematik OPUS4-5029 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Berghoff, G., ; Lanske, D., ; Schultze, K., Strangeness production in deep inelastic muon-nucleon scattering 1988 NaN Verhandlungen der Deutschen Physikalischen Gesellschaft 23 0420-0195 5 T309 T309 Fachbereich Medizintechnik und Technomathematik OPUS4-5071 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Auffray, E., ; Barbier, R., ; Brandenburg, G., ; Bruyndonckx, P., The ClearPET™ project: Development of a 2nd generation high-performance small animal PET scanner Second generation high-performance PET scanners, called ClearPET™1, have been developed by working groups of the Crystal Clear Collaboration (CCC). High sensitivity and high spatial resolution for the ClearPET camera is achieved by using a phoswich arrangement combining two different types of lutetium-based scintillator materials: LSO from CTI and LuYAP:Ce from the CCC (ISTC project). In a first ClearPET prototype, phoswich arrangements of 8×8 crystals of 2×2×10 mm3 are coupled to multi-channel photomultiplier tubes (Hamamatsu R7600). A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the ring is 120 mm, the axial detector length is 110 mm.The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the exact pulse starting time, which is subsequently used for coincidence detection. The gantry allows rotation of the detector modules around the field of view. Preliminary data shows a correct identification of the crystal layer about (98±1)%. Typically the energy resolution is (23.3±0.5)% for the luyap layer and (15.4±0.4)% for the lso layer. early studies showed the timing resolution of 2 ns FWHM and 4.8 ns FWTM. the intrinsic spatial resolution ranges from 1.37 mm to 1.61 mm full-width of half-maximum (FWHM) with a mean of 1.48 mm FWHM. further improvements in image and energy resolution are expected when the system geometry is fully modeled. 2005 4 Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 537 Proceedings of the 7th International Conference on Inorganic Scintillators and their Use in Scientific and Industrial Applications 1-2 307 311 campus http://dx.doi.org/10.1016/j.nima.2004.08.032 Fachbereich Medizintechnik und Technomathematik OPUS4-5065 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Auffray, E., ; Barbier, R., ; Brandenburg, G., The ClearPET TM LSO/LuYAP phoswich scanner: a high performance small animal PET system A 2nd generation high performance small animal PET scanner, called ClearPET™, has been designed and a first prototype is built by working groups of the Crystal Clear Collaboration (CCC). In order to achieve high sensitivity and maintain good uniform spatial resolution over the field of view in high resolution PET systems, it is necessary to extract the depth of interaction (DOI) information and correct for spatial degradation. The design of the first ClearPET™ Demonstrator based on the use of the multi-anode photomultiplier tube (Hamamatsu R7600-M64) and a LSO/LuYAP phoswich matrix. The two crystal layers of 8*8 crystals (2*2*10 mm3) are stacked on each other and mounted without light guide as one to one on the PMT. A unit of four PMTs arranged in-line represents one of 20 sectors of the ring design. The opening diameter of the crystal ring is 137 mm, the axial detector length is 110 mm. The PMT pulses are digitized by free-running ADCs and digital data processing determines the gamma energy, the phoswich layer and even the pulse arrival time. Single gamma interactions are recorded and coincidences are found by software. The gantry allows rotation of the detector modules around the field of view. The measurements have been done using the first LSO/LuYAP detector cassettes. 2004 4 2003 IEEE Nuclear Science Symposium Conference Record, Vol. 3 1728 1732 campus http://dx.doi.org/10.1109/NSSMIC.2003.1352212 Fachbereich Medizintechnik und Technomathematik OPUS4-3475 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de; Achten, R., ; Auffray, E., ; Müller-Veggian, Mattea, mueller-veggian@opus.fh-aachen.de The ClearPET™ neuro scanner: a dedicated LSO/LuYAP phoswich small animal PET scanner Piscataway, NJ IEEE Operations Center 2004 3 2004 IEEE Nuclear Science Symposium conference record : Nuclear Science Symposium, Medical Imaging Conference ; 16 - 22 October 2004, Rome, Italy ; [including the Symposium on Nuclear Power System (SNPS), 14th Room Temperature Semiconductor X- and Gamma-Ray Detectors Workshop and special focus workshops] / NPSS, Nuclear & Plasma Sciences Society. Guest ed.: J. Anthony Seibert Nuclear Science Symposium Conference Record, 2004 IEEE 2430 2433 campus https://doi.org/10.1109/NSSMIC.2004.1462747 Fachbereich Medizintechnik und Technomathematik OPUS4-5036 Wissenschaftlicher Artikel Ziemons, Karl, A measurement of the ratio of the nucleon structure function in copper and deuterium Results are presented on the ratios of the nucleon structure function in copper to deuterium from two separate experiments. The data confirm that the nucleon structure function,F 2, is different for bound nucleons than for the quasi-free ones in the deuteron. The redistribution in the fraction of the nucleon's momentum carried by quarks is investigated and it is found that the data are compatible with no integral loss of quark momenta due to nuclear effects. 1993 7 Zeitschrift für Physik C Particles and Fields 57 1431-5858 European Muon Collaboration 2 211 218 campus http://dx.doi.org//10.1007/BF01565050 Fachbereich Medizintechnik und Technomathematik OPUS4-5027 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de Jet production and fragmentation properties in deep inelastic muon scattering 1987 16 Zeitschrift für Physik C : Particles and Fields 36 0170-9739 European Muon Collaboration 4 527 543 campus http://dx.doi.org/10.1007/BF01630590 Fachbereich Medizintechnik und Technomathematik OPUS4-5028 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de A measurement of the spin asymmetry of the structure function g1 in deep inelastic muon-proton scattering The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured over a large x range (0.01http://dx.doi.org/10.1016/0370-2693(88)91523-7 Fachbereich Medizintechnik und Technomathematik OPUS4-5031 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de An investigation of the spin structure of the proton in deep inelastic scattering of polarised muons and polarised protons The spin asymmetry in deep inelastic scattering of longitudinally polarised muons by longitudinally polarised protons has been measured in the range 0.01<×<0.7. The spin dependent structure function g1(x) for the proton has been determined and, combining the data with earlier SLAC measurements, its integral over x found to be 0.126±0.010(stat.)±0.015(syst.), in disagreement with the Ellis-Jaffe sum rule. Assuming the validity of the Biorken sum rule, this result implies a significant negative value for the integral of g1 for the neutron. These integrals lead to the conclusion, in the naïve quark parton model, that the total quark spin constitutes a rather small fraction of the spin of the nucleon. Results are also presented on the asymmetries in inclusive hadron production which are consistent with the above picture. 1989 34 Nuclear Physics B 328 0550-3213 European Muon Collaboration 1 1 35 campus http://dx.doi.org/10.1016/0550-3213(89)90089-8 Fachbereich Medizintechnik und Technomathematik OPUS4-5033 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de Comparison of forward hadrons produced in muon interactions on nuclear targets and deuterium Differential multiplicities of forward produced hadrons in deep inelastic muon scattering on nuclear targets have been compared with those from deuterium. The ratios are observed to increase towards unity as the virtual photon energy increases with no significant dependence on the other muon kinematic variables. The hadron transverse momentum distribution is observed to be broadened in nuclear targets. The dependence on the remaining hadron variables is investigated and the results are discussed in the framework of intranuclear interaction models and in the context of the EMC effect. 1991 10 Zeitschrift für Physik C Particles and Fields 52 1431-5858 European Muon Collaboration 1 1 11 campus http://dx.doi.org/10.1007/BF01412322 Fachbereich Medizintechnik und Technomathematik OPUS4-5034 Wissenschaftlicher Artikel Ziemons, Karl, k.ziemons@fh-aachen.de Muoproduction of J/ψ and the gluon distribution of the nucleon Measurements are presented of the inclusive distributions of the J/Ψ meson produced by muons of energy 200 GeV from an ammonia target. The gluon distribution of the nucleon has been derived from the data in the range 0.04http://dx.doi.org/10.1007/BF01589703 Fachbereich Medizintechnik und Technomathematik OPUS4-9114 Wissenschaftlicher Artikel Zhubanova, А., ; Mansurov, Z.A., ; Digel, Ilya, ; Saviskaya, I.S., ; Akimbekov, N.Sh., Designing of Heterogeneous Nanobiocomposites for Biotechnology 2013 4 KazNU Bulletin. Biology series 59 1563-0218 No 3/1 89 93 Fachbereich Medizintechnik und Technomathematik OPUS4-9495 Teil eines Buches Zhubanova, Azhar A., ; Mansurov, Zulkhair A., ; Digel, Ilya, digel@fh-aachen.de Use of Advanced Nanomaterials for Bioremediation of Contaminated Ecosystems This chapter shows that nanomaterials obtained by high-temperature carbonization of inexpensive plant raw material such as rice husk, grape seeds, and walnut shells can serve as a basis for the production of highly efficient microbial drugs, biodestructors, biosorbents, and biocatalysts, which are promising for the remediation of the ecosystem contaminated with heavy and radioactive metals, oil and oil products. A strong interest in engineering zymology is dictated by the necessity to address the issues of monitoring enzymatic processes, treatment, and diagnosis of a number of common human diseases, environmental pollution, quality control of pharmaceuticals and food. Nanomaterials obtained by high-temperature carbonization of cheap plant raw material such as-rice husks, grape seeds and walnut shells, can serve as a basis for creating of highly effective microbial preparations-biodestructors, biosorbents and biocatalysts, which are promising for the use of contaminated ecosystems, and for restoration of human intestine microecology. Singapore Jenny Stanford Publishing 2020 25 Carbon Nanomaterials in Biomedicine and the Environment 978-981-4800-27-3 353 378 10.1201/9780429428647-18 campus https://doi.org/10.1201/9780429428647-18 Fachbereich Medizintechnik und Technomathematik OPUS4-321 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells. 2007 Fachbereich Medizintechnik und Technomathematik OPUS4-319 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Aknazarov, S. K., ; Mansurov, Zulkhair, ; Digel, Ilya, digel@fh-aachen.de; Kozhalakova, A. A., ; Akimbekov, Nuraly Shardarbekovich, ; O'Heras, Carlos, ; Tazhibayeva, S., ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment. 2010 Fachbereich Medizintechnik und Technomathematik OPUS4-11083 Wissenschaftlicher Artikel Zhen, Manghao, ; Liang, Yunpei, ; Staat, Manfred, m.staat@fh-aachen.de; Li, Quanqui, ; Li, Jianbo, Discontinuous fracture behaviors and constitutive model of sandstone specimens containing non-parallel prefabricated fissures under uniaxial compression The deformation and damage laws of non-homogeneous irregular structural planes in rocks are the basis for studying the stability of rock engineering. To investigate the damage characteristics of rock containing non-parallel fissures, uniaxial compression tests and numerical simulations were conducted on sandstone specimens containing three non-parallel fissures inclined at 0°, 45° and 90° in this study. The characteristics of crack initiation and crack evolution of fissures with different inclinations were analyzed. A constitutive model for the discontinuous fractures of fissured sandstone was proposed. The results show that the fracture behaviors of fissured sandstone specimens are discontinuous. The stress-strain curves are non-smooth and can be divided into nonlinear crack closure stage, linear elastic stage, plastic stage and brittle failure stage, of which the plastic stage contains discontinuous stress drops. During the uniaxial compression test, the middle or ends of 0° fissures were the first to crack compared to 45° and 90° fissures. The end with small distance between 0° and 45° fissures cracked first, and the end with large distance cracked later. After the final failure, 0° fissures in all specimens were fractured, while 45° and 90° fissures were not necessarily fractured. Numerical simulation results show that the concentration of compressive stress at the tips of 0°, 45° and 90° fissures, as well as the concentration of tensile stress on both sides, decreased with the increase of the inclination angle. A constitutive model for the discontinuous fractures of fissured sandstone specimens was derived by combining the logistic model and damage mechanic theory. This model can well describe the discontinuous drops of stress and agrees well with the whole processes of the stress-strain curves of the fissured sandstone specimens. Amsterdam Elsevier 2024 13 Seiten Theoretical and Applied Fracture Mechanics 131 Art. No. 104373 10.1016/j.tafmec.2024.104373 campus https://doi.org/10.1016/j.tafmec.2024.104373 Fachbereich Medizintechnik und Technomathematik OPUS4-4907 Wissenschaftlicher Artikel Zerlin, Kay, zerlin@fh-aachen.de; Kasischke, Nicole, ; Digel, Ilya, digel@fh-aachen.de; Maggakis-Kelemen, Christina, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Structural transition temperature of hemoglobins correlates with species' body temperature 2007 9 European Biophysics Journal. 37 (2007), H. 1 1432-1017 1 10 campus http://dx.doi.org/10.1007/s00249-007-0144-4 Fachbereich Medizintechnik und Technomathematik OPUS4-4905 Wissenschaftlicher Artikel Zerlin, Kay, zerlin@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Stadler, Andreas M., ; Büldt, Georg, ; Zaccai, Guiseppe, ; Artmann, Gerhard, artmann@fh-aachen.de Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions 2007 0 Regenerative medicine. 2 (2007), H. 5 1746-0751 Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany 573 573 bezahl http://dx.doi.org/10.2217/17460751.2.5.485 Fachbereich Medizintechnik und Technomathematik OPUS4-7959 Wissenschaftlicher Artikel Zange, Jochen, ; Schopen, Kathrin, ; Albracht, Kirsten, albracht@fh-aachen.de; Gerlach, Darius A., ; Frings-Meuthen, Petra, ; Maffiuletti, Nicola A., ; Bloch, Wilhelm, ; Rittweger, Jörn, Using the Hephaistos orthotic device to study countermeasure effectiveness of neuromuscular electrical stimulation and dietary lupin protein supplementation, a randomised controlled trial 2017 Plos one 12 2 10.1371/journal.pone.0171562 Fachbereich Medizintechnik und Technomathematik OPUS4-9413 Buch (Monographie) Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de Yoshinobu, Tatsuo; Schöning, Michael Josef Light-addressing and chemical imaging technologies for electrochemical sensing Basel MDPI 2020 122 Pages 978-3-03943-029-1 This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors 10.3390/books978-3-03943-029-1 weltweit https://doi.org/10.3390/books978-3-03943-029-1 Fachbereich Medizintechnik und Technomathematik OPUS4-9536 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors (LAPS) for cell monitoring and biosensing Amsterdam Elsevier 2021 Current Opinion in Electrochemistry In Press, Journal Pre-proof 10.1016/j.coelec.2021.100727 bezahl https://doi.org/10.1016/j.coelec.2021.100727 Fachbereich Medizintechnik und Technomathematik OPUS4-7288 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Moritz, Werner, ; Finger, Friedhelm, ; Schöning, Michael Josef, schoening@fh-aachen.de Comini, Elisabetta Application of thin-film amorphous silicon to chemical imaging 2006 9 Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. 9781558998711 Materials Research Society symposia proceedings; v. 915 Paper 0910-A-20-01 1 10 Fachbereich Medizintechnik und Technomathematik OPUS4-8064 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-ichiro, ; Werner, Frederik, f.werner@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species 2017 21 Annual Review of Analytical Chemistry 10 225 246 10.1146/annurev-anchem-061516-045158 Fachbereich Medizintechnik und Technomathematik OPUS4-4682 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-Ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Miniaturized and high-speed chemical imaging systems - 2012 9 Nano-Boomedical Engineering 2012 :Proceedings of the Tohoku University Global Centre of Excellence Programme / Sakura Hall, Tohoku University, Sendai Japan, 5 – 6 March 2012 / ed. by Takami Yamaguchi 386 395 bezahl http://dx.doi.org/10.1142/9781848169067_0045 Fachbereich Medizintechnik und Technomathematik OPUS4-6666 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor Amsterdam Elsevier 2015 6 Sensors and actuators B: Chemical 207 Part B 926 932 campus https://dx.doi.org/10.1016/j.snb.2014.09.002 Fachbereich Medizintechnik und Technomathematik OPUS4-8606 Teil eines Buches Yoshinobu, Tatsuo, ; Krause, Steffi, ; Miyamoto, Ko-ichiro, ; Werner, Frederik, f.werner@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de (Bio-)chemical Sensing and Imaging by LAPS and SPIM The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications. Cham Springer 2018 29 Label-free biosensing: advanced materials, devices and applications 978-3-319-75219-8 103 132 campus https://doi.org/10.1007/5346_2017_22 Fachbereich Medizintechnik und Technomathematik OPUS4-1965 Wissenschaftlicher Artikel Yoshinobu, T., ; Yasuhito, U., ; Iwasaki, H., ; Näther, Niko, naether@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Koudelka-Hep, M., Applications of the light-addressable potentiometric sensor to microfluidic devices Roma 2004 790 S.: Ill., graph. Darst. 1 CD-ROM Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale]. 88-7621-282-5 Eurosensors ; (18, 2004, Roma) 434 437 Fachbereich Medizintechnik und Technomathematik OPUS4-1755 Wissenschaftlicher Artikel Yoshinobu, T., ; Ui, Y., ; Iwasaki, H., ; Näther, Niko, naether@fh-aachen.de; Koudelka-Hep, M., ; Schöning, Michael Josef, schoening@fh-aachen.de Potentiometric imaging in a microfluidic channel 2004 1 Biomedizinische Technik. 49 (2004), H. 2 0932-4666 998 999 Fachbereich Medizintechnik und Technomathematik OPUS4-1979 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Furuichi, K., ; Mourzina, Yu, ; Ermelenko, Yu, ; Iwasaki, I., Portable light-addressable potentiometric sensor (LAPS) for multisensor applications Prague Czech Technical University, Faculty of Electrical Engineering, Department of Measurement 2002 3 Book of abstracts / ed. by J. Saneistr. 80-01-02576-4 Eurosensors ; (16, 2002, Praha) 898 901 Fachbereich Medizintechnik und Technomathematik OPUS4-1768 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Furuichi, K., ; Mourzina, Y., ; Ermelenko, Y., ; Iwasaki, H., Portable light-addressable potentiometric sensor (LAPS) for multisensor applications 2003 4 Sensors and Actuators B. 95 (2003), H. 1-3 0925-4005 352 356 campus http://dx.doi.org/10.1016/S0925-4005(03)00437-4 Fachbereich Medizintechnik und Technomathematik OPUS4-1751 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Finger, F., ; Moritz, W., ; Iwasaki, H., Fabrication of thin-film LAPS with amorphous silicon 2004 6 Sensors. 4 (2004), H. 10 1424-8220 163 169 weltweit http://www.mdpi.org/sensors/papers/s41000163.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-6854 Konferenzveröffentlichung Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Finger, F., ; Moritz, W., ; Iwasaki, H., Thin-film a-Si LAPS : Preparation and pH sensitivity 2003 1 Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimarães, Portugal, September 21 - 24, 2003 Eurosensors <17, 2003, Guimarães> 88 89 weltweit http://repositorium.sdum.uminho.pt/bitstream/1822/4837/1/BookOfAbstractsFinal.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-1954 Wissenschaftlicher Artikel Yoshinobu, T., ; Iwasaki, H., ; Ui, Y., ; Furuichi, K., ; Ermelenko, Y., ; Mourzina, Y., ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Näther, Niko, naether@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de The light-addressable potentiometric sensor for multi-ion sensing and imaging 2005 3 Methods. 37 (2005), H. 1 1046-2023 99 102 campus http://dx.doi.org/10.1016/j.ymeth.2005.05.020 Fachbereich Medizintechnik und Technomathematik OPUS4-1974 Wissenschaftlicher Artikel Yoshinobu, T., ; Ermelenko, Y., ; Mourzina, Y., ; Schöning, Michael Josef, schoening@fh-aachen.de; Iwasaki, H., ; Vlasov, Y., Multi-component analysis based on the light-addressable potentiometric sensor (LAPS) Wunstorf AMA Service 2003 3 Proceedings : 11th international conference Sensor 2003; 13 - 15 May 2003, Exhibition Centre Nuremberg, Germany Internationale Messe mit Kongress Sensor <11, 2003, Nürnberg> 141 144 Fachbereich Medizintechnik und Technomathematik OPUS4-1874 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Simonis, A., ; Iwasaki, H., ; Lüth, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Constant-current-mode LAPS (CLAPS) for the detection of penicillin 2001 3 Electroanalysis. 13 (2001), H. 8-9 1040-0397 733 736 campus http://www3.interscience.wiley.com/cgi-bin/abstract/82502248/ABSTRACT Fachbereich Medizintechnik und Technomathematik OPUS4-1812 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Lüth, H., ; Iwasaki, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Alternative sensor materials for light-addressable potentiometric sensors 2001 4 Sensors and Actuators B. 76 (2001), H. 1-3 0925-4005 388 392 campus http://dx.doi.org/10.1016/S0925-4005(01)00646-3 Fachbereich Medizintechnik und Technomathematik OPUS4-1688 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Ismail, Md.A.B., ; Iwasaki, H., ; Lüth, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Chemical imaging sensor and its application to biological systems Amsterdam [u.a.] Elsevier [u.a.] 2001 385 S. : Ill., graph. Darst. Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz 0-08-044014-2 259 263 Fachbereich Medizintechnik und Technomathematik OPUS4-10996 Wissenschaftlicher Artikel Yang, Peng-Fei, ; Kriechbaumer, Andreas, ; Albracht, Kirsten, Albracht@fh-aachen.de; Sanno, Maximilian, ; Ganse, Bergita, ; Koy, Timmo, ; Shang, Peng, ; brüggemann, Gert-Peter, ; Müller, Lars Peter, ; Rittweger, Jörn, A novel optical approach for assessing in vivo bone segment deformation and its application in muscle-bone relationship studies in humans Singapore Elsevier 2014 0 Journal of Orthopaedic Translation 2 4 238 238 10.1016/j.jot.2014.07.078 https://www.sciencedirect.com/science/article/pii/S2214031X14001582?via%3Dihub Fachbereich Medizintechnik und Technomathematik OPUS4-6113 Konferenzveröffentlichung Wu, Chunsheng, c.wu@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Wang, Ping, ; Schöning, Michael Josef, schoening@fh-aachen.de An application of a scanning light-addressable potentiometric sensor for label-free DNA detection 2013 4 11. Dresdner Sensor-Symposium : 9.-11.12.2013 978-3-9813484-5-3 164 168 weltweit http://dx.doi.org/10.5162/11dss2013/A9 Fachbereich Medizintechnik und Technomathematik OPUS4-7692 Wissenschaftlicher Artikel Wu, Chunsheng, C.Wu@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules. Amsterdam Elsevier 2016 6 Sensors and Actuators B: Chemical 229 506 512 10.1016/j.snb.2016.02.004 bezahl https://doi.org/10.1016/j.snb.2016.02.004 Fachbereich Medizintechnik und Technomathematik OPUS4-7046 Wissenschaftlicher Artikel Wu, Chunsheng, C.Wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer 2015 7 Nanoscale 7 6143 6150 10.1039/C4NR07225A Fachbereich Medizintechnik und Technomathematik OPUS4-6444 Wissenschaftlicher Artikel Wu, Chunsheng, c.wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge. Weinheim Wiley-VCH 2014 5 Physica status solidi A : Applications and materials science 211 6 1423 1428 10.1002/pssa.201330442 campus https://doi.org/10.1002/pssa.201330442 Fachbereich Medizintechnik und Technomathematik OPUS4-6725 Konferenzveröffentlichung Wu, Chunsheng, c.wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de DNA-hybridization detection using light-addressable potentiometric sensor modified with gold layer Düsseldorf VDE-Verl. 2014 1 CD-ROM Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250) 978-3-8007-3622-5 1 4 Fachbereich Medizintechnik und Technomathematik