Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-319 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Aknazarov, S. K., ; Mansurov, Zulkhair, ; Digel, Ilya, digel@fh-aachen.de; Kozhalakova, A. A., ; Akimbekov, Nuraly Shardarbekovich, ; O'Heras, Carlos, ; Tazhibayeva, S., ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment. 2010 Fachbereich Medizintechnik und Technomathematik OPUS4-321 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells. 2007 Fachbereich Medizintechnik und Technomathematik OPUS4-341 Wissenschaftlicher Artikel Akimbekov, Nuraly Shardarbekovich, ; Mansurov, Zulkhair, ; Jandosov, J., ; Digel, Ilya, digel@fh-aachen.de; Gossmann, Matthias, ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Zhubanova, Azhar A., Wound healing activity of carbonized rice husk The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls. Bäch Trans Tech Publications, Switzerland 2013 Fachbereich Medizintechnik und Technomathematik OPUS4-334 Konferenzveröffentlichung Mansurov, Zulkhair, ; Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Savitskaja, Irina S., ; Kozhalakova, A. A., ; Kistaubaeva, Aida S., The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it's microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties - ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS. 2008 Fachbereich Medizintechnik und Technomathematik OPUS4-4901 Wissenschaftlicher Artikel Kozhalakova, A. A., ; Zhubanova, Azhar A., ; Mansurov, Z. A., ; Digel, Ilya, digel@fh-aachen.de; Tazhibayeva, S. M., ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Adsorption of bacterial lipopolysaccharides on carbonized rice shell 2010 4 Science of Central Asia (2010) 50 54 weltweit http://www.scientificfund.kz/index.php?option=com_content&view=article&id=16:adsorption-of-bacterial-lipopolysaccharides-on-carbonized-rice-shell&catid=4:1&Itemid=13 Fachbereich Medizintechnik und Technomathematik OPUS4-4945 Wissenschaftlicher Artikel Digel, Ilya, digel@fh-aachen.de; Zhubanova, Azhar A., ; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology 2004 6 Biotechnologija : teorija i praktika (2004) 1028-9399 46 52 Fachbereich Medizintechnik und Technomathematik OPUS4-6513 Wissenschaftlicher Artikel Mansurov, Z. A., ; Jandosov, J. M., ; Kerimkulova, A. R., ; Azat, S., ; Zhubanova, A. A., ; Digel, Ilya, digel@fh-aachen.de; Savistkaya, I. S., ; Akimbekov, N. S., ; Kistaubaeva, A. S., Nanostructured carbon materials for biomedical use One of the priority trends of carbon nanotechnology is creation of nanocomposite systems. Such carbon nanostructured composites were produced using - raw materials based on the products of agricultural waste, such as grape stones, apricot stones, rice husk. These products have a - wide spectrum of application and can be obtained in large quantities. The Institute of Combustion Problems has carried out the work on synthesis of the nanostructured carbon sorbents for multiple applications including the field of biomedicine. The article presents the data on the synthesis and physico-chemical properties of carbonaceous sorbents using physicochemical methods of investigation: separation and purification of biomolecules; isolation of phytohormone - fusicoccin; adsorbent INGO-1 in the form of an adsorption column for blood detoxification, oral (entero) sorbent - INGO-2; the study of efferent and probiotic properties and sorption activity in regard to the lipopolysaccharide (LPS), new biocomposites - based on carbonized rice husk (CRH) and cellular microorganisms; the use of CRH in wound treatment. A new material for blood detoxication (INGO-1) has been obtained. Adsorption of p-cresyl sulfate and indoxyl sulfate has shown that active carbon adsorbent can remove clinically significant level of p-cresyl sulfate and indoxyl sulfate from human plasma. Enterosorbent INGO-2 possesses high adsorption activity in relation to Gram-negative bacteria and their endotoxins. INGO-2 slows down the growth of conditionally pathogenic microorganisms, without having a negative effect on bifido and lactobacteria. The use of enterosorbent INGO-2 for sorption therapy may provide a solution to a complex problem - detoxication of the digestive tract and normalization of the intestinal micro ecology. The immobilized probiotic called "Riso-lact" was registered at the Ministry of Health of the Republic of Kazakhstan as a biologically active food additive. The developed technology is patented and provides production of the medicine in the form of freeze-dried biomass immobilized in vials. Almaty Institute of Combustion Problems 2014 8 Eurasian chemico-technological journal : quarterly journal of the International Higher Education Academy of Sciences 15 (2013) 3 209 217 10.18321/ectj224 weltweit https://doi.org/10.18321/ectj224 Fachbereich Medizintechnik und Technomathematik OPUS4-8415 Buch (Monographie) Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de Artmann, Gerhard; Temiz Artmann, Aysegül; Zhubanova, Azhar A.; Digel, Ilya Biological, physical and technical basics of cell engineering Singapore Springer 2018 xxiv, 481 Seiten ; Illustrationen, Diagramme 978-981-10-7903-0 Fachbereich Chemie und Biotechnologie OPUS4-8366 Teil eines Buches Digel, Ilya, digel@fh-aachen.de; Akimbekov, Nuraly Sh., ; Kistaubayeva, Aida, ; Zhubanova, Azhar A., Artmann, Gerhard; Temiz Artmann, Aysegül; Zhubanova, Azhar A.; Digel, Ilya Microbial Sampling from Dry Surfaces: Current Challenges and Solutions Sampling of dry surfaces for microorganisms is a main component of microbiological safety and is of critical importance in many fields including epidemiology, astrobiology as well as numerous branches of medical and food manufacturing. Aspects of biofilm formation, analysis and removal in aqueous solutions have been thoroughly discussed in literature. In contrast, microbial communities on air-exposed (dry) surfaces have received significantly less attention. Diverse surface sampling methods have been developed in order to address various surfaces and microbial groups, but they notoriously show poor repeatability, low recovery rates and suffer from lack of mutual consistency. Quantitative sampling for viable microorganisms represents a particular challenge, especially on porous and irregular surfaces. Therefore, it is essential to examine in depth the factors involved in microorganisms' recovery efficiency and accuracy depending on the sampling technique used. Microbial colonization, retention and community composition on different dry surfaces are very complex and rely on numerous physicochemical and biological factors. This study is devoted to analyze and review the (a) physical phenomena and intermolecular forces relevant for microbiological surface sampling; (b) challenges and problems faced by existing sampling methods for viable microorganisms and (c) current directions of engineering and research aimed at improvement of quality and efficiency of microbiological surface sampling. Singapore Springer 2018 35 Biological, Physical and Technical Basics of Cell Engineering 978-981-10-7904-7 421 456 10.1007/978-981-10-7904-7_19 campus https://doi.org/10.1007/978-981-10-7904-7_19 Fachbereich Medizintechnik und Technomathematik OPUS4-9107 Wissenschaftlicher Artikel Mansurov, Z., ; Digel, Ilya, digel@fh-aachen.de; Biisenbaev, M., ; Savistkaya, I., ; Kistaubaeva, A., ; Akimbekov, N., ; Zhubanova, A., Bio-composite material on the basis of carbonized rice husk in biomedicine and environmental applications Almaty Institute of Combustion Problems 2012 16 Eurasian Chemico-Technological Journal 14 2 115 131 10.18321/ectj105 weltweit https://doi.org/10.18321/ectj105 Fachbereich Medizintechnik und Technomathematik