Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-314 Wissenschaftlicher Artikel Bassam, Rasha, bassam@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Hescheler, Jürgen, ; Graef, T., ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Arinkin, Vladimir, ; Gossmann, Matthias, ; Digel, Ilya, digel@fh-aachen.de Alterations in human hemoglobin structure related to red blood cell storage The importance of the availability of stored blood or blood cells, respectively, for urgent transfusion cannot be overestimated. Nowadays, blood storage becomes even more important since blood products are used for epidemiological studies, bio-technical research or banked for transfusion purposes. Thus blood samples must not only be processed, stored, and shipped to preserve their efficacy and safety, but also all parameters of storage must be recorded and reported for Quality Assurance. Therefore, blood banks and clinical research facilities are seeking more accurate, automated means for blood storage and blood processing. 2011 Fachbereich Medizintechnik und Technomathematik OPUS4-315 Wissenschaftlicher Artikel Preiß, C., ; Linder, Peter, linder@fh-aachen.de; Wendt, K., ; Krystek, M., ; Digel, Ilya, digel@fh-aachen.de; Gossmann, Matthias, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Bassam, Rasha, bassam@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Engineering technology for plant physiology and plant stress research Plant physiology and plant stress: Plant physiology will be much more important for human mankind because of yield and cultivation limits of crops determined by their resistance to stress. To assess and counteract various stress factors it is necessary to conduct plant research to gain information and results on plant physiology. 2011 Fachbereich Medizintechnik und Technomathematik OPUS4-316 Wissenschaftlicher Artikel Seifarth, Volker, ; Schehl, D., ; Linder, Peter, linder@fh-aachen.de; Gossmann, Matthias, ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Preiß, C., ; Kayser, Peter, kayser@fh-aachen.de; Pack, O., ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Ureplace: development of a bioreactor for in vitro culturing of cell seeded tubular vessels on collagen scaffolds The demand of replacements for inoperable organs exceeds the amount of available organ transplants. Therefore, tissue engineering developed as a multidisciplinary field of research for autologous in-vitro organs. Such three dimensional tissue constructs request the application of a bioreactor. The UREPLACE bioreactor is used to grow cells on tubular collagen scaffolds OPTIMAIX Sponge 1 with a maximal length of 7 cm, in order to culture in vitro an adequate ureter replacement. With a rotating unit, (urothelial) cells can be placed homogeneously on the inner scaffold surface. Furthermore, a stimulation is combined with this bioreactor resulting in an orientation of muscle cells. These culturing methods request a precise control of several parameters and actuators. A combination of a LabBox and the suitable software LabVision is used to set and conduct parameters like rotation angles, velocities, pressures and other important cell culture values. The bioreactor was tested waterproof successfully. Furthermore, the temperature controlling was adjusted to 37 °C and the CO2 - concentration regulated to 5 %. Additionally, the pH step responses of several substances showed a perfect functioning of the designed flow chamber. All used software was tested and remained stable for several days. 2011 Fachbereich Medizintechnik und Technomathematik OPUS4-319 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Aknazarov, S. K., ; Mansurov, Zulkhair, ; Digel, Ilya, digel@fh-aachen.de; Kozhalakova, A. A., ; Akimbekov, Nuraly Shardarbekovich, ; O'Heras, Carlos, ; Tazhibayeva, S., ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Adsorption of bacterial Lipopolysaccharides and blood plasma proteins on modified carbonized materials Bacterial lipopolysaccharides (endotoxins) show strong biological effects at very low concentrations in human beings and many animals when entering the blood stream. These include affecting structure and function of organs and cells, changing metabolic functions, raising body temperature, triggering the coagulation cascade, modifying hemodynamics and causing septic shock. Because of this toxicity, the removal of even minute amounts is essential for safe parenteral administration of drugs and also for septic shock patients' care. The absence of a general method for endotoxin removal from liquid interfaces urgently requires finding new methods and materials to overcome this gap. Nanostructured carbonized plant parts is a promising material that showed good adsorption properties due to its vast pore network and high surface area. The aim of this study was comparative measurement of endotoxin- and blood proteins-related adsorption rate and adsorption capacity for different carboneous materials produced at different temperatures and under different surface modifications. As a main surface modificator, positively cbarged polymer, polyethileneimine (PEl) was used. Activated carbon materials showed good adsorption properties for LPS and some proteins used in the experiments. During the batch experiments, several techniques (dust removal, autoclaving) were used and optimized for improving the material's adsorption behavior. Also, with the results obtained it was possible to differentiate the materials according to their adsorption capacity and kinetic characteristics. Modification of the surface apparently has not affected hemoglobin binding to the adsorbent's surface. Obtained adsorption isotherms can be used as a powerful tool for designing of future column-based setups for blood purification from LPS, which is especially important for septic shock treatment. 2010 Fachbereich Medizintechnik und Technomathematik OPUS4-321 Wissenschaftlicher Artikel Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology The most of conventional methods of air purification use the power of a fan to draw in air and pass it through a filter. The problem of bacterial contamination of inner parts of such a type of air conditioners in some cases draws attention towards alternative air-cleaning systems. Some manufacturers offer to use the ozone's bactericidal and deodorizing effects, but the wide spreading of such systems is restricted by the fact that toxic effects of ozone in respect of human beings are well known. In 2000 Sharp Inc. introduced "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions (I 0-14 ). This technology has been developed for those customers that are conscious about health and hygiene. In our experiments, we focused on some principal aspects of plasma-generated ions application - time-dependency and irreversibility of bactericidal action, spatial and kinetic characteristics of emitted cluster particles, their chemical targets in the microbial cells. 2007 Fachbereich Medizintechnik und Technomathematik OPUS4-324 Konferenzveröffentlichung Artmann, Gerhard, artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Biophysical and Engineering Contributions to Plant Research Tests with palm tree leaves have just started yet and scan data are in the process to be analyzed. The final goal of future project for palm tree gender and species recognition will be to develop optical scanning technology to be applied to date palm tree leaves for in-situ screening purposes. Depending on the software used and the particular requirements of the users the technology potentially shall be able to identify palm tree diseases, palm tree gender, and species of young date palm trees by scanning leaves. 2011 Fachbereich Medizintechnik und Technomathematik OPUS4-325 Konferenzveröffentlichung Dachwald, Bernd, dachwald@fh-aachen.de; Xu, Changsheng, ; Feldmann, Marco, feldmann@fh-aachen.de; Plescher, Engelbert, plescher@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Development and testing of a subsurface probe for detection of life in deep ice : [abstract] We present the novel concept of a combined drilling and melting probe for subsurface ice research. This probe, named "IceMole", is currently developed, built, and tested at the FH Aachen University of Applied Sciences' Astronautical Laboratory. Here, we describe its first prototype design and report the results of its field tests on the Swiss Morteratsch glacier. Although the IceMole design is currently adapted to terrestrial glaciers and ice shields, it may later be modified for the subsurface in-situ investigation of extraterrestrial ice, e.g., on Mars, Europa, and Enceladus. If life exists on those bodies, it may be present in the ice (as life can also be found in the deep ice of Earth). 2011 Fachbereich Medizintechnik und Technomathematik OPUS4-327 Konferenzveröffentlichung Artmann, Gerhard, artmann@fh-aachen.de; Stadler, Andreas M., ; Embs, Jan P., ; Zaccai, Giuseppe, ; Büldt, Georg, ; Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de The crucial role of water in a phase transition of hemoglobin at body temperature : [abstract] The observation of a temperature transition of hemoglobin occurring at a critical temperature close to body temperature 2010 Fachbereich Medizintechnik und Technomathematik OPUS4-338 Konferenzveröffentlichung Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Nojima, H., Plasma cluster ions (PCI) influence on microbial cells viability : [abstract] Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new plasma cluster device releases into the air positive and negative ions, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. A lot of phenomenological tests of the PCI air purification technology on microbial cells have been conducted. And, in most cases, it has been shown that PCI demonstrate strongly pronounced killing effect. Although, the particular mechanisms of PCI action are still not evident. We studied variations in resistance to PCI among gram-positive airborne microorganisms, as well as some dose-dependent, spatial, cultural and biochemical properties of PCI action in respect of Staphylococcus spp, Enterococcus spp, Micrococcus spp. 2003 Fachbereich Medizintechnik und Technomathematik OPUS4-339 Konferenzveröffentlichung Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de Effects of plasma generated ions on bacteria : [poster] Summary and Conclusions PCIs were clearly effective in terms of their antibacterial effects with the strains tested. This efficacy increased with the time the bacteries were exposed to PCIs. The bactericidal action has proved to be irreversible. PCIs were significantly less effective in shadowed areas. PCI exposure caused multiple protein damages as observed in SDS PAGE studies. There was no single but multiple molecular mechanism causing the bacterial death. 2003 Fachbereich Medizintechnik und Technomathematik OPUS4-340 Konferenzveröffentlichung Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de Some peculiarities of application of cluster ions generated by plasma in respect of indoor air purification :[abstract] Recently, the SHARP Corporation, Japan, has developed the world's first "Plasma Cluster Ions (PCI)" air purification technology using plasma discharge to generate cluster ions. The new plasma cluster device releases positive and negative ions into the air, which are able to decompose and deactivate harmful airborne substances by chemical reactions. Because cluster ions consist of positive and negative ions that normally exist in the natural world, they are completely harmless and safe to humans. The amount of ozone generated by cluster ions is less than 0.01 ppm, which is significantly less than the 0.05-ppm standard for industrial operations and consumer electronics. This amount, thus, has no harming effects whatsoever on the human body. But particular properties and chemical processes in PCI treatment are still under study. It has been shown that PCI in most cases show strongly pronounced irreversible killing effects in respect of airborne microflora due to free-radical induced reactions and can be considered as a potent technology to disinfect both home, medical and industrial appliances. 2003 Fachbereich Medizintechnik und Technomathematik OPUS4-341 Wissenschaftlicher Artikel Akimbekov, Nuraly Shardarbekovich, ; Mansurov, Zulkhair, ; Jandosov, J., ; Digel, Ilya, digel@fh-aachen.de; Gossmann, Matthias, ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Zhubanova, Azhar A., Wound healing activity of carbonized rice husk The carbonized rice husk (CRH) was evaluated for its wound healing activity in rats using excision models. In this study, the influences of CRH on wound healing in rat skin in vivo and cellular behavior of human dermal fibroblasts in vitro were investigated. The obtained results showed that the CRH treatment promoted wound epithelization in rats and exhibited moderate inhibition of cell proliferation in vitro. CRH with lanolin oil treated wounds were found to epithelize faster as compared to controls. Bäch Trans Tech Publications, Switzerland 2013 Fachbereich Medizintechnik und Technomathematik OPUS4-328 Konferenzveröffentlichung Digel, Ilya, digel@fh-aachen.de; Leimena, W., ; Dachwald, Bernd, dachwald@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Funke, O., ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de In-situ biological decontamination of an ice melting probe : [abstract] The objective of our study was to investigate the efficacy of different in-situ decontamination protocols in the conditions of thermo-mechanical ice-melting. 2010 Fachbereich Medizintechnik und Technomathematik OPUS4-332 Konferenzveröffentlichung Bassam, Rasha, bassam@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Effect of nitric oxide on protein thermal stability : [abstract] As a deduction from these results, we can conclude that proteins mainly in vitro, denaturate totally at a temperature between 57°C -62°C, and they also affected by NO and different ions types. In which mainly, NO cause earlier protein denaturation, which means that, NO has a destabilizing effect on proteins, and also different ions will alter the protein denaturation in which, some ions will cause earlier protein denaturation while others not. 2009 Fachbereich Medizintechnik und Technomathematik OPUS4-333 Konferenzveröffentlichung Digel, Ilya, digel@fh-aachen.de; Dachwald, Bernd, dachwald@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Funke, O., A concept of a probe for particle analysis and life detection in icy environments A melting probe equipped with autofluorescence-based detection system combined with a light scattering unit, and, optionally, with a microarray chip would be ideally suited to probe icy environments like Europa's ice layer as well as the polar ice layers of Earth and Mars for recent and extinct live. 2009 Fachbereich Medizintechnik und Technomathematik OPUS4-334 Konferenzveröffentlichung Mansurov, Zulkhair, ; Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Savitskaja, Irina S., ; Kozhalakova, A. A., ; Kistaubaeva, Aida S., The sorption of LPS toxic shock by nanoparticles on base of carbonized vegetable raw materials Immobilization of lactobacillus on high temperature carbonizated vegetable raw material (rice husk, grape stones) increases their physiological activity and the quantity of the antibacterial metabolits, that consequently lead to increase of the antagonistic activity of lactobacillus. It is implies that the use of the nanosorbents for the attachment of the probiotical microorganisms are highly perspective for decision the important problems, such as the probiotical preparations delivery to the right address and their attachment to intestines mucosa with the following detoxication of gastro-intestinal tract and the normalization of it's microecology. Besides that, thus, the received carbonizated nanoparticles have peculiar properties - ability to sorption of LPS toxical shock and, hence, to the detoxication of LPS. 2008 Fachbereich Medizintechnik und Technomathematik OPUS4-335 Konferenzveröffentlichung Stadler, Andreas M., ; Embs, Jan P., ; Zerlin, Kay, zerlin@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Zaccai, Joe, ; Büldt, Georg, Temperature transitions of hemoglobin and cytosolic water diffusion in human red blood cells : [poster] Background Hemoglobin interactions in red blood cells Hemoglobin dynamics in human red blood cells Diffusion of H2O in red blood cells 2007 Fachbereich Medizintechnik und Technomathematik OPUS4-337 Konferenzveröffentlichung Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de Plasma-generated cluster ions' effects on indoor microflora : [abstract] Recently, SHARP corporation has developed the world's first "Plasma Cluster Ions® (PCI)" air purification technology, which uses plasma discharge to generate cluster ions. The new Plasma Cluster Device releases positive and negative ions into the air, which are harmless to humans and are able to decompose and deactivate airborne substances by chemical reactions. In the past, phenomenological tests on the efficacy of the PCI air purification technology on microbial cells have been conducted. In most cases, it has been shown that PCI demonstrated strongly pronounced killing effects on microorganisms. However, the particular mechanisms of PCI action still have to be uncovered. 2003 Fachbereich Medizintechnik und Technomathematik OPUS4-1838 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Burns, Laura, ; Canaves, Jaume M., ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Circular dichroism spectra of human hemoglobin reveal a reversible structural transition at body temperature 2004 6 European Biophysics Journal. 33 (2004), H. 6 1432-1017 490 496 campus http://dx.doi.org/10.1007/s00249-004-0401-8 Fachbereich Medizintechnik und Technomathematik OPUS4-1840 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Trzewik, Jürgen, ; Ates, M., A novel method to quantify mechanical tension in cell monolayers. Trzewik, Jürgen; Ates, M., Artmann, Gerhard Michael 2002 2 Biomedizinische Technik. 47 (2002), H. Suppl. 1. Pt. 1 0013-5585 Druckausgabe unter 63 Z 47 vorhanden 379 381 Fachbereich Medizintechnik und Technomathematik OPUS4-1841 Wissenschaftlicher Artikel Maggakis-Kelemen, Christina, ; Biselli, Manfred, biselli@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Determination of the elastic shear modulus of cultured human red blood cells 2002 3 Biomedizinische Technik. 47 (2002), H. Suppl. 1 Pt. 1 0013-5585 Druckausgabe unter 63 Z 471 vorhanden 106 109 Fachbereich Medizintechnik und Technomathematik OPUS4-1842 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Zhou-Stache, J., ; Buettner, R., ; Mittermayer, C. [u.a.], Inhibition of TNF-alpha induced cell death in HUVEC and Jurkat cells by protocatechuic acid. Zhou-Stache, J.; Buettner, R.; Artmann, Gerhard Michael; Mittermayer, C.; Bosserhoff, A. K. 2002 5 Medical and Biological Engineering and Computing. 40 (2002), H. 6 0140-0118 698 703 Fachbereich Medizintechnik und Technomathematik OPUS4-1843 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Trzewik, Jürgen, ; Mallipattu, S. K., ; Delano, F. A. [u.a.], Evidence for a second valve system in Lymphatics: Endothelial Microvalves. Trzewik, Jürgen; Mallipattu, S. K.; Artmann, Gerhard Michael; Delano, F. A.; Schmid-Schonbein, G. W 2001 6 The FASEB Journal. 15 (2001) 1530-6860 1711 1717 weltweit http://www.fasebj.org/cgi/reprint/15/10/1711.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-1844 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Bäumler, H., ; Voigt, A., ; Mitlöhner, R. [u.a.], Plastic behaviour of polyelectrolyte microcapsules derived from colloid templates. Bäumler, H., Artmann, Gerhard Michael; Voigt, A., Mitlöhner, R., Neu, B., Kiesewetter, H. 2000 4 Journal of Microencapsulation. 17 (2000), H. 5 1464-5246 651 655 bezahl http://www.journalsonline.tandf.co.uk/openurl.asp?genre=article&eissn=1464-5246&volume=17&issue=5&spage=651 Fachbereich Medizintechnik und Technomathematik OPUS4-1845 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Gorbatenkova, E. A., ; Panasenko, O. M., Hypochlorous acid and human blood low density lipoproteins modified by hypochlorous acid increase erythrocyte adhesion to endothelial cells. Gorbatenkova, E. A.; Artmann, Gerhard Michael; Panasenko, O. M. 2000 9 Membrane and cell biology. 13 (2000), H. 4 1023-6597 537 546 Fachbereich Medizintechnik und Technomathematik OPUS4-1846 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Kelemen, C., ; Chien, S., Temperature transition of human hemoglobin at body temperature: effects of calcium. Kelemen, C.; Chien, S.; Artmann, Gerhard Michael 2001 8 Biophysical journal. 80 (2001), H. 6 1542-0086 2622 2630 weltweit http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1301450&blobtype=pdf Fachbereich Medizintechnik und Technomathematik OPUS4-1847 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Hueck, I. S., ; Hollweg, H. G., ; Schmid-Schönbein, G. W., Chlorpromazine modulates the Morphological Macro- and Microstructure of Endothelial Cells. Hueck, I. S.; Hollweg, H. G.; Schmid-Schönbein, G. W.; Artmann, Gerhard Michael 2000 5 American Journal of Physiology. Cell Physiology. 278 (2000), H. 5 1522-1563 Zählung: C873- C878 873 878 weltweit http://ajpcell.physiology.org/cgi/reprint/278/5/C873.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-1848 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Li, Anlan, ; Seipelt, H., ; Müller, C. [u.a.], Effects of salicylic acid derivatives on red blood cell membranes. Li, Anlan; Seipelt, H.; Müller, C.;Shi, Yong de; Artmann, Gerhard Michael 1999 5 Pharmacology and Toxicology. 85 (1999) 0902-9938 206 211 Fachbereich Medizintechnik und Technomathematik OPUS4-1849 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Hovav, T., ; Goldfarb, A., ; Yedgar, S. [u.a.], Enhanced adherence of beta-thalassaemic erythrocytes to endothelial cells. Hovav, T., Goldfarb, A.; Artmann, Gerhard Michael, Yedgar, S.; Barstein, G. 1999 3 British Journal of Haematology. 106 (1999), H. 1 1365-2141 178 181 campus http://dx.doi.org/10.1046/j.1365-2141.1999.01489.x Fachbereich Medizintechnik und Technomathematik OPUS4-1850 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Kelemen, Christina, ; Porst, Dariusz, porst@fh-aachen.de; Büldt, G. [u.a.], Temperature transitions of protein properties in human red blood cells. Artmann, Gerhard Michael, Kelemen, Christina; Porst, D.; Büldt, G.; Chien, S. 1998 4 Biophysical Journal. 75 (1998), H. 6 1542-0086 http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1299989&blobtype=pdf 3179 3183 Fachbereich Medizintechnik und Technomathematik OPUS4-1851 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Shi, Young de, ; Agosti, R., ; Longhini, E., A modified casson equation to characterize blood rheology for hypertension. Shi, Young de; Artmann, Gerhard Michael; Agosti, R.; Longhini, E. 1998 12 Clinical Hemorheology Microcirculation. 19 (1998), H. 2 1386-0291 115 127 bezahl http://iospress.metapress.com/openurl.asp?genre=article&issn=1386-0291&volume=19&issue=2&spage=115 Fachbereich Medizintechnik und Technomathematik OPUS4-1853 Wissenschaftlicher Artikel Li, Anlan, ; Shi, Young de, ; Landsmann, B., ; Schankowski-Bouvier, P., ; Dikta, Gerhard, dikta@fh-aachen.de; Bauer, U., ; Artmann, Gerhard, artmann@fh-aachen.de Hemorheology and walking distance of Peripheral Arterial Occlusive Disease patients during treatment with Ginkgo-biloba extract 1998 4 Acta Pharmacologica Sinica = ZHONGUO YAOLI XUEBAO. 19 (1998), H. 5 1745-7254 ISSN der parallelen Ausgabe 1671-4083; China-Zs.-Code: CN31-1347 abstract frei unter 417 421 weltweit http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10375799&query_hl=1&itool=pubmed_DocSum Fachbereich Medizintechnik und Technomathematik OPUS4-1870 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Schikarsky, C., Ginkgo Biloba extract (EGb 761) protects red blood cells from oxidative damage. Artmann, Gerhard Michael; Schikarsky, C. 1993 10 Clinical Hemorheology. 13 (1993), H. 4 0271-5198 529 539 Fachbereich Medizintechnik und Technomathematik OPUS4-1871 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de A microscopic photometric method for measuring erythrocyte deformability. Artmann, Gerhard Michael 1986 10 Clinical Hemorheology. 6 (1986) 0271-5198 617 627 Fachbereich Medizintechnik und Technomathematik OPUS4-1872 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Schmid-Schönbein, H., ; Grebe, R., ; Teitel, P. [u.a.], Restoration of Microsieve Filterability of Human Red Cells After Exposure to Hyperosmolarity and Lactazidosis: Effect of Vinpocetine. Schmid-Schönbein, H.; Grebe, R.; Teitel, P.; Artmann, Gerhard Michael, Eschweiler, H.; Schröder, Susanne 1988 6 Drug Development Research. 14 (1988), H. 3-4 1098-2299 Abstracts frei unter: 205 211 weltweit http://www3.interscience.wiley.com/cgi-bin/abstract/109670814/ABSTRACT Fachbereich Medizintechnik und Technomathematik OPUS4-1873 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Schmid-Schönbein, H., ; Schröder, Susanne, ; Grebe, R. [u.a.], Influence of Moxaverine-HCL on Membrane Curvature and Microsieve Filterability of Red Cells after Exposure to Hyperosmolarity and Lactacidosis. Schmid-Schönbein, H.; Schröder, Susanne; Grebe, R.; Artmann, Gerhard Michael, Eschweiler, H; Teitel, P. 1988 6 Arzneimittelforschung. 38 (1988), H. 5 0004-4172 710 716 Fachbereich Medizintechnik und Technomathematik OPUS4-1875 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Zang, Werner, zang@fh-aachen.de Fully automatic measurement of rheologic parameters of red blood cells = Laborautomat zur Messung mechanischer Eigenschaften roter Blutzellen 1990 2 Biomedizinische Technik = Biomedical engineering. 35 (1990), H. Suppl. 3 0013-5585 94 96 Fachbereich Medizintechnik und Technomathematik OPUS4-1859 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Sung, K.-L. Paul, ; Horn, Thomas, ; Whittemore, Darren [u.a.], Micropipette aspiration of human erythrocytes induces echinocytes via membrane phospholipid translocation. Artmann, Gerhard Michael; Sung, K.-L. Paul; Horn, Thomas; Whittemore, Darren; Norwich, Gerald; Chien, Shu 1997 7 Biophysical journal. 72 (1997), H. 3 1542-0086 1434 1441 weltweit http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1184526&blobtype=pdf Fachbereich Medizintechnik und Technomathematik OPUS4-1861 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Li, Anlan, ; Ziemer, J., ; Schneider, G. [u.a.], A photometric method to analyze induced erythrocyte shape changes. Artmann, Gerhard Michael; Li, Anlan; Ziemer, J.; Schneider, G.; Sahm, U.: ; Ziemer, J.; Schneider, G.; Sahm, U. 1996 14 Biorheology. 33 (1996), H. 3 0006-355x 251 265 Fachbereich Medizintechnik und Technomathematik OPUS4-1864 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de 2nd International Conference on Medical Biorheology (ICMB). Shanghai, China, September 13-15, 1995. Shi, Young de, Artmann, Gerhard Michael, Meiselman, Herbert J. 1996 2 Biorheology. 33 (1996), H. 6 0006-355x 505 507 Fachbereich Medizintechnik und Technomathematik OPUS4-1865 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de Microscopic photometric quantification of stiffness and relaxation time of red blood cells in a flow chamber. Artmann, Gerhard Michael 1995 17 Biorheology. 32 (1995), H. 5 0006-355x 553 570 Fachbereich Medizintechnik und Technomathematik OPUS4-1867 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Li, Anlan, Dihydroergocryptine maintains erythrocyte fluidity in acidotic and hyperosmolar suspensions modelling hypoxic and ischemic microcirculation. Li, Anlan; Artmann, Gerhard Michael 1994 13 Clinical Hemorheology. 15 (1994), H. 2 0271-5198 133 146 Fachbereich Medizintechnik und Technomathematik OPUS4-1868 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Schmid-Schönbein, H., The microscope-photometrical-monolayer-technique- a new principle for analyzing the distribution of rheological responses in pathological and experimentally modified red cell populations. Artmann, Gerhard Michael; Schmid-Schönbein, H. Amsterdam [u.a.] Excerpta Medica 1987 2 Microcirculation, an update : proceedings of the Fourth World Congress for Microcirculation, Tokyo, Japan, July 26-30, 1987 0444809511 World Congress for Microcirculation (4, 1987, Tokyo;); International congress series ; 755 475 477 Fachbereich Medizintechnik und Technomathematik OPUS4-1890 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Teitel, P., ; Schmid-Schönbein, H., Variable rheologische Antwort der Erythrozyten auf den Einfluß von Xantinderivaten (Coffein): Experimentelle Differenzierung von "Responders" und "Nonresponders" Basel [u.a.] Karger [u.a.] 1987 5 11. Jahrestagung der Gesellschaft für Mikrozirkulation 100 105 Fachbereich Medizintechnik und Technomathematik OPUS4-1892 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Grebe, R., ; Homrighausen, A., ; Wolff, H., ; [u.a.], , Response of normal and diabetic erythrocytes to membrane deformation by chemical and mechanical forces. Artmann, Gerhard Michael; Grebe, R.; Homrighausen, A.; Wolff, H.; Teitel, P.; Schmid-Schönbein, H. Basel [u.a.] Karger [u.a.] 1988 4 12. Jahrestagung der Gesellschaft für Mikrozirkulation 196 200 Fachbereich Medizintechnik und Technomathematik OPUS4-1896 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Keller, U., ; Haas, J., ; Amort, U., ; Zang, Werner, zang@fh-aachen.de; Karschies, S., Technik und ausgewählte Applikationen eines Membranbioassays roter Blutzellen 1991 1 Biomedizinische Technik = Biomedical engineering. 36 (1991) 36 0013-5585 S1 450 451 campus http://dx.doi.org/10.1515/bmte.1991.36.s1.450 Fachbereich Medizintechnik und Technomathematik OPUS4-1897 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Montanus, M., ; Teitel, P., Die photometrische Kapillaraggregation- ein neues Verfahren zur Messung der Erythrozytenaggregation. Montanus, M.; Artmann, Gerhard Michael; Teitel, P. 1991 2 Biomedizinische Technik = Biomedical engineering. 36 (1991) 0013-5585 213 215 Fachbereich Medizintechnik und Technomathematik OPUS4-1898 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Witte, Ch., Expertensystem für Personal Computer zur Strukturbestimmung des Circulus Arteriosus Willisii mittels transkranieller Dopplersonografie. Witte, Ch.; Artmann, Gerhard Michael 1991 2 Biomedizinische Technik = Biomedical engineering. 36 (1991) 0013-5585 228 230 Fachbereich Medizintechnik und Technomathematik OPUS4-3154 Wissenschaftlicher Artikel Maggakis-Kelemen, C., ; Bork, M., ; Kayser, Peter, kayser@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Biological and mechanical quality of red blood cells cultured from human umbilical cord blood stem cells 2003 6 Medical and biological engineering and computing. 41 (2003), H. 3 0140-0118 350 356 campus http://dx.doi.org/10.1007/BF02348442 Fachbereich Chemie und Biotechnologie OPUS4-3463 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Hueck, Isgard S., ; Rossiter, Katharine, ; Schmid-Schönbein, Geert W., Fluid Shear Attenuates Endothelial Pseudopodia Formation into the Capillary Lumen / Hueck, Isgard S. ; Rossiter, Katharine ; Artman, Gerhard M. ; Schmid-Schönbein, Geert W. 2008 11 Microcirculation. 15 (2008), H. 6 1549-8719 531 542 campus http://dx.doi.org/10.1080/10739680801904174 Fachbereich Medizintechnik und Technomathematik OPUS4-3464 Buch (Monographie) Artmann, Gerhard, artmann@fh-aachen.de Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) Berlin Springer 2008 978-3-540-75408-4 bezahl http://dx.doi.org/10.1007/978-3-540-75409-1 Fachbereich Medizintechnik und Technomathematik OPUS4-3466 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Zerlin, Kay, zerlin@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de Hemoglobin Senses Body Temperature Berlin Springer 2008 32 Bioengineering in Cell and Tissue Research / Artmann, Gerhard M. ; Chien, Shu (Eds.) 978-3-540-75408-4 415 447 bezahl http://dx.doi.org/10.1007/978-3-540-75409-1_17 Fachbereich Medizintechnik und Technomathematik OPUS4-3800 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Zerlin, Kay, zerlin@fh-aachen.de; Maggakis-Kelemen, Christina, ; Linder, Peter, linder@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Kayser, Peter, ; Stadler, David, stadler@fh-aachen.de; Dikta, Gerhard, dikta@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Hemoglobin senses body temperature 2009 11 European Biophysics Journal 38 0175-7571 5 589 600 campus http://dx.doi.org/10.1007/s00249-009-0410-8 Fachbereich Medizintechnik und Technomathematik OPUS4-3760 Wissenschaftlicher Artikel Kaul, D. K., ; Koshkaryev, A., ; Artmann, Gerhard, artmann@fh-aachen.de; Barshtein, G., ; Yedgar, S., Additive effect of red blood cell rigidity and adherence to endothelial cells in inducing vascular resistance 2008 NaN American Journal of Physiology : Heart and Circulation Physiology . 295 (2008), H. 4 295 4 H1788 H1793 weltweit http://dx.doi.org/10.1152/ajpheart.253.2008 Fachbereich Medizintechnik und Technomathematik OPUS4-3762 Wissenschaftlicher Artikel Stadler, A. M., ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Embs, Jan P., ; Zaccai, Joe, ; Büldt, Georg, Hemoglobin Dynamics in Red Blood Cells: Correlation to Body Temperature 2008 12 Biophysical Journal. 95 (2008), H. 11 1542-0086 5449 5461 campus http://dx.doi.org/10.1529/biophysj.108.138040 Fachbereich Medizintechnik und Technomathematik OPUS4-3801 Wissenschaftlicher Artikel Sadykov, Rustam, ; Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Savitskaya, Irina, ; Zhubanova, Azhar, Oral lead exposure induces dysbacteriosis in rats 2009 9 Journal of Occupational Health. 51 (2009) (2009), H. 1 1348-9585 64 73 weltweit http://dx.doi.org/10.1539/joh.M8009 Fachbereich Medizintechnik und Technomathematik OPUS4-3892 Wissenschaftlicher Artikel Stadler, Andreas M., ; Garvey, G. J., ; Bocahut, A., ; Sacquin-Mora, S., ; Digel, Ilya, digel@fh-aachen.de; Schneider, G. J., ; Natali, F., ; Artmann, Gerhard, artmann@fh-aachen.de; Zaccai, G., Thermal fluctuations of haemoglobin from different species : adaptation to temperature via conformational dynamics 2012 10 Journal of the Royal Society Interface. 9 (2012), H. 76 1742-5689 2845 2855 weltweit http://rsif.royalsocietypublishing.org/content/9/76/2845.long Fachbereich Medizintechnik und Technomathematik OPUS4-3894 Wissenschaftlicher Artikel Demirci, Taylan, ; Kurulgan Demirci, Eylem, ; Trzewik, Jürgen, ; Linder, Peter, linder@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Sakizli, Meral, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Gene expression profile analysis of 3T3/NIH fibroblasts after one hour mechanical stress Weinheim Wiley-VCH 2009 1 IUBMB Life. 61 (2009), H. 3 1521-6543 Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey 311 312 campus http://dx.doi.org/10.1002/iub.183 Fachbereich Medizintechnik und Technomathematik OPUS4-3896 Wissenschaftlicher Artikel Becker, C., ; Wallang, C., ; Artmann, Gerhard, artmann@fh-aachen.de; Jakse, G., Mechanotransduction-bioreactor for tissue engineering of a ureter prosthesis 2008 0 International Journal of Artificial Organs, The 31 Abstracts from the XXXV Congress of the European Society for Artificial Organs: 'Towards Future Biomedical Technologies' - ORAL PRESENTATIONS 7 583 583 Fachbereich Medizintechnik und Technomathematik OPUS4-3878 Wissenschaftlicher Artikel Bork, M., ; Kelemen, C., ; Biselli, Manfred, biselli@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Biophysikalische Charakterisierung ex vivo kultivierter menschlicher Erythrozythen 2000 1 Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1 1862-278X 471 472 campus http://dx.doi.org/10.1515/bmte.2000.45.s1.471 Fachbereich Medizintechnik und Technomathematik OPUS4-3880 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Stache, O., ; Königsfeld, J., Temperaturabhängigkeit der Pseudopodienbildung und Rückbildung von Granulozyten / Stache, O. ; Königsfeld, J. ; Artmann, G. M. 2000 1 Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1 1862-278X 450 451 campus http://dx.doi.org/10.1515/bmte.2000.45.s1.450 Fachbereich Medizintechnik und Technomathematik OPUS4-3881 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Trzewik, J., ; Schmid-Schönbein, G. W., Investigation on lymphatic endothelial microvalves / Trzewik, J. ; Artmann, G. M. ; Schmid-Schönbein, G. W. 2000 1 Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1 1862-278X 521 522 campus http://dx.doi.org/10.1515/bmte.2000.45.s1.521 Fachbereich Medizintechnik und Technomathematik OPUS4-3882 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Vogel, A., ; Zink, S., ; Stache, O., Entwicklung eines automatisierten, computergesteuerten Permeabilitätsanalysators zur Messung an Endothelzellen / Vogel, A. ; Zinke, S. ; Stache, O. ; Königsfeld, J. ; Artmann, G. 2000 1 Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1 1862-278X 479 480 campus http://dx.doi.org/10.1515/bmte.2000.45.s1.479 Fachbereich Medizintechnik und Technomathematik OPUS4-3907 Wissenschaftlicher Artikel Linder, Peter, linder@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de High-throughput testing of mechanical forces generated in thin cell and tissue layers 2007 0 Tissue Engineering. 13 (2007), H. 7 1076-3279 Meeting abstract 433 1778 1778 Fachbereich Medizintechnik und Technomathematik OPUS4-3877 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de Cellular engineering - a challenge for engineers? / Artmann, G. M. 2000 Biomedizinische Technik = Biomedical Engineering. 45 (2000), H. s1 1862-278X 449 campus http://dx.doi.org/10.1515/bmte.2000.45.s1.449 Fachbereich Medizintechnik und Technomathematik OPUS4-3835 Wissenschaftlicher Artikel Demirci, T., ; Trzewik, J., ; Linder, Peter, linder@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: Real Time PCR Products and Suppliers by Comparison 2004 1 Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2 0932-4666 1046 1047 Fachbereich Medizintechnik und Technomathematik OPUS4-3837 Wissenschaftlicher Artikel Demirci, T., ; Trzewik, J., ; Linder, Peter, linder@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Mechanical Stimulation of 3T3 Fibroblasts Activates Genes: ITGB5 and p53 Responses as Quantified on the mRNA Level 2004 1 Biomedizinische Technik . 49 (2004), H. Erg.-Bd. 2 0932-4666 1030 1031 Fachbereich Medizintechnik und Technomathematik OPUS4-4241 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Kelemen, C., ; Porst, Dariusz, porst@fh-aachen.de; Büldt, G., Cellular engineering: Crash tests an menschlichen Erythrozyten geben Aufschluß über versteckte Materialeigenschaften zellulärer Proteine / Artmann, G. M. ; Kelemen, Ch. ; Porst, D. ; Büldt, G. ; Chien, Shu 1998 1 Biomedizinische Technik / Biomedical Engineering. 43 (1998), H. s1 1862-278 446 447 campus http://dx.doi.org/10.1515/bmte.1998.43.s1.446 Fachbereich Medizintechnik und Technomathematik OPUS4-4433 Wissenschaftlicher Artikel Eijck, Lambert van, ; Demmel, Franz, ; Artmann, Gerhard, artmann@fh-aachen.de; Stadtler, Andreas Maximilian, Macromolecular dynamics in red blood cells investigated using neutron spectroscopy London The Royal Society 2011 10 Journal of the Royal Society Interface 8 1742-5689 57 590 600 campus http://dx.doi.org/10.1098/rsif.2010.0306 Fachbereich Medizintechnik und Technomathematik OPUS4-4434 Wissenschaftlicher Artikel Kurulgan Demirci, Eylem, ; Demirci, T., ; Trzewik, Jürgen, ; Linder, Peter, linder@fh-aachen.de; Karakulah, G., ; Artmann, Gerhard, artmann@fh-aachen.de; Sakizli, M., ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Genome-Wide Gene Expression Analysis of NIH 3T3 Cell Line Under Mechanical Stimulation Berlin Springer 2011 9 Cellular and molecular bioengineering. 4 (2011), H. 1 1865-5025 46 55 campus http://dx.doi.org/10.1007/s12195-010-0149-4 Fachbereich Medizintechnik und Technomathematik OPUS4-4523 Wissenschaftlicher Artikel Amin, Rashid, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Lazarovici, Philip, ; Lelkes, Peter I., Permeability of an In Vitro Model of Blood Brain Barrier (BBB) 2009 3 13th International Conference on Biomedical Engineering / Lim, Chwee Teck [Ed.] 978-3-540-92841-6 IFMBE Proceedings ; 23, Track 1 ; ICBME 2008 3-6 December 2008 Singapore 81 84 bezahl http://dx.doi.org/10.1007/978-3-540-92841-6_20 Fachbereich Medizintechnik und Technomathematik OPUS4-4538 Wissenschaftlicher Artikel Leimena, W., ; Artmann, Gerhard, artmann@fh-aachen.de; Dachwald, Bernd, dachwald@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Gossmann, Matthias, ; Digel, Ilya, digel@fh-aachen.de Feasibility of an in-situ microbial decontamination of an ice-melting probe 2010 5 Eurasian Chemico-Technological Journal. 12 (2010), H. 2 1562-3920 145 150 Fachbereich Medizintechnik und Technomathematik OPUS4-4892 Buch (Monographie) Artmann, Gerhard, artmann@fh-aachen.de Stem cell engineering : principles and applications / Gerhard M. Artmann ... eds. Berlin [u.a.] Springer 2011 XLI, 541 S. : Ill., graph. Darst. 978-3-642-11864-7 campus http://www.springerlink.com/content/t7t307/#section=802513&page=1 Fachbereich Medizintechnik und Technomathematik OPUS4-4897 Wissenschaftlicher Artikel Stadler, Andreas M., ; Digel, Ilya, digel@fh-aachen.de; Embs, Jan P., ; Unruh, Tobias, ; Tehei, M., ; Zaccai, G., ; Büldt, G., ; Artmann, Gerhard, artmann@fh-aachen.de From powder to solution : Hydration dependence of human hemoglobin dynamics correlated to body temperature Cambridge, Mass. Cell Press 2009 8 Biophysical Journal. 96 (2009), H. 12 0006-3495 5073 5081 campus http://dx.doi.org/10.1016/j.bpj.2009.03.043 Fachbereich Medizintechnik und Technomathematik OPUS4-4898 Wissenschaftlicher Artikel Kurz, R., ; Linder, Peter, linder@fh-aachen.de; Trzewik, Jürgen, ; Rüffer, M., ; Artmann, Gerhard, artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Rothermel, A., ; Robitzki, A., ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Contractile tension and beating rates of self-exciting monolayers and 3D-tissue constructs of neonatal rat cardiomyocytes 2010 6 Medical and Biological Engineering and Computing. 48 (2010), H. 1 1741-0444 59 65 campus http://www.springerlink.com/content/v24817k767n01l47/ Fachbereich Medizintechnik und Technomathematik OPUS4-4901 Wissenschaftlicher Artikel Kozhalakova, A. A., ; Zhubanova, Azhar A., ; Mansurov, Z. A., ; Digel, Ilya, digel@fh-aachen.de; Tazhibayeva, S. M., ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Adsorption of bacterial lipopolysaccharides on carbonized rice shell 2010 4 Science of Central Asia (2010) 50 54 weltweit http://www.scientificfund.kz/index.php?option=com_content&view=article&id=16:adsorption-of-bacterial-lipopolysaccharides-on-carbonized-rice-shell&catid=4:1&Itemid=13 Fachbereich Medizintechnik und Technomathematik OPUS4-4903 Wissenschaftlicher Artikel Stadler, Andreas M., ; Embs, Jan P., ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Unruh, Tobias, ; Büldt, Georg, ; Zaccai, Guiseppe, Cytoplasmic water and hydration layer dynamics in human red blood cells 2008 1 Journal of the American Chemical Society. 50 (2008), H. 130 1520-5126 16852 16853 campus http://pubs.acs.org/doi/abs/10.1021/ja807691j Fachbereich Medizintechnik und Technomathematik OPUS4-4904 Wissenschaftlicher Artikel Digel, Ilya, digel@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Molecular processes in biological thermosensation 2008 8 Journal of Biophysics. 2008 (2008) 1687-8000 1 9 weltweit http://dx.doi.org/10.1155/2008/602870 Fachbereich Medizintechnik und Technomathematik OPUS4-4905 Wissenschaftlicher Artikel Zerlin, Kay, zerlin@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Stadler, Andreas M., ; Büldt, Georg, ; Zaccai, Guiseppe, ; Artmann, Gerhard, artmann@fh-aachen.de Dynamics and interactions of hemoglobin in human red blood cells and concentrated hemoglobin solutions 2007 0 Regenerative medicine. 2 (2007), H. 5 1746-0751 Proceedings of the 3rd World Congress on Regenerative Medicine. October 18-20, 2007. Leipzig, Germany 573 573 bezahl http://dx.doi.org/10.2217/17460751.2.5.485 Fachbereich Medizintechnik und Technomathematik OPUS4-4907 Wissenschaftlicher Artikel Zerlin, Kay, zerlin@fh-aachen.de; Kasischke, Nicole, ; Digel, Ilya, digel@fh-aachen.de; Maggakis-Kelemen, Christina, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Kayser, Peter, kayser@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Structural transition temperature of hemoglobins correlates with species' body temperature 2007 9 European Biophysics Journal. 37 (2007), H. 1 1432-1017 1 10 campus http://dx.doi.org/10.1007/s00249-007-0144-4 Fachbereich Medizintechnik und Technomathematik OPUS4-4911 Wissenschaftlicher Artikel Trzewik, Jürgen, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Demirci, T., ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Evaluation of lateral mechanical tension in thin-film tissue constructs 2004 8 Annals of Biomedical Engineering. 32 (2004), H. 9 1573-9686 1243 1251 campus http://dx.doi.org/10.1114/B:ABME.0000039358.71180.9a Fachbereich Medizintechnik und Technomathematik OPUS4-4930 Wissenschaftlicher Artikel Digel, Ilya, digel@fh-aachen.de; Dachwald, Bernd, dachwald@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Funke, O., A concept of a probe for particle analysis and life detection in icy environments 2009 23 International workshop "Europa lander: science goals and experiments", Space Research Institute (IKI), Moscow, Russia 9-13 February 2009 1 24 weltweit http://www.iki.rssi.ru/conf/2009elw/presentations/presentations_pdf/session7/digel_ELW.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-4945 Wissenschaftlicher Artikel Digel, Ilya, digel@fh-aachen.de; Zhubanova, Azhar A., ; Nojima, H., ; Artmann, Gerhard, artmann@fh-aachen.de The use of bactericidal effects of cluster ions generated by plasma in medical biotechnology 2004 6 Biotechnologija : teorija i praktika (2004) 1028-9399 46 52 Fachbereich Medizintechnik und Technomathematik OPUS4-4916 Wissenschaftlicher Artikel Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Nishikawa, K., ; Artmann, Gerhard, artmann@fh-aachen.de Cluster air-ion effects on bacteria and moulds 2004 1 Biomedizinische Technik. 49 (2004), H. Erg.-Bd. 2 0932-4666 1040 1041 Fachbereich Medizintechnik und Technomathematik OPUS4-4917 Wissenschaftlicher Artikel Maggakis-Kelemen, Christina, ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Polystyrene sulfonate/Polyallylamine hydrochloride microcapsules as potential artificial red blood cells - improvement of capsule flexibility 2005 2 Biomedizinische Technik. 50 (2005), H. Erg.-Bd. 1 324 326 Fachbereich Medizintechnik und Technomathematik OPUS4-4920 Wissenschaftlicher Artikel Stadler, Andreas M., ; Zerlin, Kay, zerlin@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Büldt, Georg, ; Zaccai, Guiseppe, ; Artmann, Gerhard, artmann@fh-aachen.de Dynamics and interactions of hemoglobin in red blood cells 2008 0 Tissue Engineering Part A. 14 (2008), H. 5 1937-3341 TERMIS EU 2008 Porto Meeting June 22-26, 2008 Porto Congress Center-Alfândega Portugal 724 724 bezahl http://online.liebertpub.com/doi/pdfplus/10.1089/tea.2008.1504 Fachbereich Medizintechnik und Technomathematik OPUS4-4921 Wissenschaftlicher Artikel Kurulgan Demirci, Eylem, ; Linder, Peter, linder@fh-aachen.de; Demirci, Taylan, ; Trzewik, Jürgen, ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Contractile tension of endothelial cells: An LPS based in-vitro sepsis model Weinheim Wiley 2009 1 IUBMB Life. 61 (2009), H. 3 1521-6543 Abstracts: Turkish Society of Molecular Medicine, Third International Congress of Molecular Medicine, May 5-8, 2009, Istanbul, Turkey 307 308 campus http://dx.doi.org/10.1002/iub.183 Fachbereich Medizintechnik und Technomathematik OPUS4-4923 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de Mechanism of haemoglobin sensing body temperature 2008 0 Tissue Engineering Part A. 14 (2008), H. 5 1937-3341 TERMIS EU 2008 Porto Meeting June 22-26, 2008 Porto Congress Center-Alfândega Portugal 754 754 bezahl http://online.liebertpub.com/doi/pdfplus/10.1089/tea.2008.1504 Fachbereich Medizintechnik und Technomathematik OPUS4-4924 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Zerlin, Kay, zerlin@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Stadler, Andreas M., Physical discontinuities at body temperature in human red blood cells / Artmann, GM ; Zerlin, K ; Digel, I ; Stadler, A ; Zaccai, G ; Temiz, AA 2007 0 Tissue Engineering. 13 (2007), H. 7 1076-3279 TERMIS-EU Meeting Abstracts London, UK September 4-7, 2007 1778 1778 bezahl http://online.liebertpub.com/toc/ten/13/7 Fachbereich Medizintechnik und Technomathematik OPUS4-4972 Wissenschaftlicher Artikel Bassam, Rasha, bassam@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Hescheler, Jürgen, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Effects of spermine NONOate and ATP on protein aggregation: light scattering evidences London BioMed Central 2013 13 BMC Biophysics 2046-1682 1 14 10.1186/2046-1682-6-1 http://dx.doi.org/10.1186/2046-1682-6-1 Fachbereich Medizintechnik und Technomathematik OPUS4-5195 Wissenschaftlicher Artikel Artmann, Gerhard, artmann@fh-aachen.de; Zang, Werner, zang@fh-aachen.de Vollautomatische Messung rheologischer Parameter roter Blutzellen 1990 2 Biomedizinische Technik / Biomedical Engineering 35 S3 94 96 campus http://dx.doi.org/10.1515/bmte.1990.35.s3.94 Fachbereich Medizintechnik und Technomathematik OPUS4-6090 Wissenschaftlicher Artikel Micili, Serap C., ; Valter, Markus, ; Oflaz, Hakan, ; Ozogul, Candan, ; Linder, Peter, linder@fh-aachen.de; Föckler, Nicole, ; Artmann, Gerhard, artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Optical coherence tomography : a potential tool to predict premature rupture of fetal membranes London Sage 2013 8 Proceedings of the Institution of Mechanical Engineers. Part H : Journal of engineering in medicine Vol. 227 No. 4 393 401 campus http://pih.sagepub.com/content/227/4/393.full.pdf+html Fachbereich Medizintechnik und Technomathematik OPUS4-6388 Wissenschaftlicher Artikel Arinkin, Vladimir, ; Digel, Ilya, digel@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Phenotyping date palm varieties via leaflet cross-sectional imaging and artificial neural network application Background True date palms (Phoenix dactylifera L.) are impressive trees and have served as an indispensable source of food for mankind in tropical and subtropical countries for centuries. The aim of this study is to differentiate date palm tree varieties by analysing leaflet cross sections with technical/optical methods and artificial neural networks (ANN). Results Fluorescence microscopy images of leaflet cross sections have been taken from a set of five date palm tree cultivars (Hewlat al Jouf, Khlas, Nabot Soltan, Shishi, Um Raheem). After features extraction from images, the obtained data have been fed in a multilayer perceptron ANN with backpropagation learning algorithm. Conclusions Overall, an accurate result in prediction and differentiation of date palm tree cultivars was achieved with average prediction in tenfold cross-validation is 89.1% and reached 100% in one of the best ANN. 2014 7 BMC bioinformatics 15 55 1 8 10.1186/1471-2105-15-55 weltweit https://doi.org/10.1186/1471-2105-15-55 Fachbereich Medizintechnik und Technomathematik OPUS4-6627 Wissenschaftlicher Artikel Stadler, Alexander Maximilian, ; Garvey, Christopher J., ; Embs, Jan Peter, ; Koza, Michael Marek, ; Unruh, Tobias, ; Artmann, Gerhard, artmann@fh-aachen.de; Zaccai, Guiseppe, Picosecond dynamics in haemoglobin from different species: A quasielastic neutron scattering study Amsterdam Elsevier 2014 10 Biochimica et biophysica acta (BBA): General Subjects 1840 10 2989 2999 10.1016/j.bbagen.2014.06.007 bezahl https://doi.org/10.1016/j.bbagen.2014.06.007 Fachbereich Luft- und Raumfahrttechnik OPUS4-6976 Wissenschaftlicher Artikel Seifarth, Volker, seifarth@fh-aachen.de; Goßmann, Matthias, gossmann@fh-aachen.de; Grosse, J. O., ; Becker, C., ; Heschel, I., ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Development of a Bioreactor to Culture Tissue Engineered Ureters Based on the Application of Tubular OPTIMAIX 3D Scaffolds Basel Karger 2015 7 Urologia Internationalis 2015 95 106 113 10.1159/000368419 bezahl Fachbereich Chemie und Biotechnologie OPUS4-7622 Wissenschaftlicher Artikel Goßmann, Matthias, gossmann@fh-aachen.de; Frotscher, Ralf, frotscher@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Bayer, Robin, bayer@fh-aachen.de; Epple, U., ; Staat, Manfred, m.staat@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Mechano-pharmacological characterization of cardiomyocytes derived from human induced pluripotent stem cells Background/Aims: Common systems for the quantification of cellular contraction rely on animal-based models, complex experimental setups or indirect approaches. The herein presented CellDrum technology for testing mechanical tension of cellular monolayers and thin tissue constructs has the potential to scale-up mechanical testing towards medium-throughput analyses. Using hiPS-Cardiac Myocytes (hiPS-CMs) it represents a new perspective of drug testing and brings us closer to personalized drug medication. Methods: In the present study, monolayers of self-beating hiPS-CMs were grown on ultra-thin circular silicone membranes and deflect under the weight of the culture medium. Rhythmic contractions of the hiPS-CMs induced variations of the membrane deflection. The recorded contraction-relaxation-cycles were analyzed with respect to their amplitudes, durations, time integrals and frequencies. Besides unstimulated force and tensile stress, we investigated the effects of agonists and antagonists acting on Ca²⁺ channels (S-Bay K8644/verapamil) and Na⁺ channels (veratridine/lidocaine). Results: The measured data and simulations for pharmacologically unstimulated contraction resembled findings in native human heart tissue, while the pharmacological dose-response curves were highly accurate and consistent with reference data. Conclusion: We conclude that the combination of the CellDrum with hiPS-CMs offers a fast, facile and precise system for pharmacological, toxicological studies and offers new preclinical basic research potential. Basel Karger 2016 16 Cellular physiology and biochemistry 38 3 1182 1198 10.1159/000443124 weltweit http://dx.doi.org/10.1159/000443124 Fachbereich Medizintechnik und Technomathematik OPUS4-7584 Wissenschaftlicher Artikel Kowalski, Julia, kowalski@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Zierke, S., ; Wulfen, B. van, ; Clemens, J., ; Konstantinidis, K., ; Ameres, G., ; Hoffmann, R., ; Mikucki, J., ; Tulaczyk, S., ; Funke, O., ; Blandfort, D., ; Espe, Clemens, c.espe@fh-aachen.de; Feldmann, Marco, feldmann@fh-aachen.de; Francke, Gero, francke@fh-aachen.de; Hiecker, S., ; Plescher, Engelbert, plescher@fh-aachen.de; Schöngarth, Sarah, schoengarth@fh-aachen.de; Dachwald, Bernd, dachwald@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Eliseev, D., ; Heinen, D., ; Scholz, F., ; Wiebusch, C., ; Macht, S., ; Bestmann, U., ; Reineking, T., ; Zetzsche, C., ; Schill, K., ; Förstner, R., ; Niedermeier, H., ; Szumski, A., ; Eissfeller, B., ; Naumann, U., ; Helbing, K., Navigation technology for exploration of glacier ice with maneuverable melting probes The Saturnian moon Enceladus with its extensive water bodies underneath a thick ice sheet cover is a potential candidate for extraterrestrial life. Direct exploration of such extraterrestrial aquatic ecosystems requires advanced access and sampling technologies with a high level of autonomy. A new technological approach has been developed as part of the collaborative research project Enceladus Explorer (EnEx). The concept is based upon a minimally invasive melting probe called the IceMole. The force-regulated, heater-controlled IceMole is able to travel along a curved trajectory as well as upwards. Hence, it allows maneuvers which may be necessary for obstacle avoidance or target selection. Maneuverability, however, necessitates a sophisticated on-board navigation system capable of autonomous operations. The development of such a navigational system has been the focal part of the EnEx project. The original IceMole has been further developed to include relative positioning based on in-ice attitude determination, acoustic positioning, ultrasonic obstacle and target detection integrated through a high-level sensor fusion. This paper describes the EnEx technology and discusses implications for an actual extraterrestrial mission concept. Amsterdam Elsevier 2016 17 Cold Regions Science and Technology 123 53 70 10.1016/j.coldregions.2015.11.006 bezahl https://doi.org/10.1016/j.coldregions.2015.11.006 Fachbereich Medizintechnik und Technomathematik OPUS4-7588 Teil eines Buches Digel, Ilya, digel@fh-aachen.de; Sadykov, R., ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de Changes in intestinal microflora in rats induced by oral exposure to low lead (II) concentrations Nova Science Publ. 2015 24 Lead Exposure and Poisoning: Clinical Symptoms, Medical Management and Preventive Strategies 9781634826990 75 99 bezahl Fachbereich Medizintechnik und Technomathematik OPUS4-8080 Konferenzveröffentlichung Schlemmer, Katharina, ; Porst, Dariusz, porst@fh-aachen.de; Bassam, Rasha, bassam@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de Erni, Daniel; Fischerauer, Alice; Himmel, Jörg; Seeger, Thomas; Thelen, Klaus Effects of nitric oxide (NO) and ATP on red blood cell phenotype and deformability Duisburg Universität Duisburg-Essen 2017 1 2nd YRA MedTech Symposium 2017 : June 8th - 9th / 2017 / Hochschule Ruhr-West 978-3-9814801-9-1 A young researchers track of the 7th IEEE Workshop & SENSORICA 2017 100 101 10.17185/duepublico/43984 weltweit https://doi.org/10.17185/duepublico/43984 Fachbereich Medizintechnik und Technomathematik OPUS4-8161 Wissenschaftlicher Artikel Seifarth, Volker, ; Grosse, Joachim O., ; Grossmann, Matthias, ; Janke, Heinz Peter, ; Arndt, Patrick, ; Koch, Sabine, ; Epple, Matthias, ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Mechanical induction of bi-directional orientation of primary porcine bladder smooth muscle cells in tubular fibrin-poly(vinylidene fluoride) scaffolds for ureteral and urethral repair using cyclic and focal balloon catheter stimulation London Sage 2017 9 Journal of Biomaterials Applications 32 3 321 330 10.1177/0885328217723178 Fachbereich Chemie und Biotechnologie OPUS4-8415 Buch (Monographie) Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Zhubanova, Azhar A., ; Digel, Ilya, digel@fh-aachen.de Artmann, Gerhard; Temiz Artmann, Aysegül; Zhubanova, Azhar A.; Digel, Ilya Biological, physical and technical basics of cell engineering Singapore Springer 2018 xxiv, 481 Seiten ; Illustrationen, Diagramme 978-981-10-7903-0 Fachbereich Chemie und Biotechnologie OPUS4-8363 Teil eines Buches Artmann, Gerhard, artmann@fh-aachen.de; Meruvu, Haritha, ; Kizildag, Sefa, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Artmann, Gerhard; Temiz Artmann, Aysegül; Zhubanova, Azhar A.; Digel, Ilya Functional Toxicology and Pharmacology Test of Cell Induced Mechanical Tensile Stress in 2D and 3D Tissue Cultures Mechanical forces/tensile stresses are critical determinants of cellular growth, differentiation and migration patterns in health and disease. The innovative "CellDrum technology" was designed for measuring mechanical tensile stress of cultured cell monolayers/thin tissue constructs routinely. These are cultivated on very thin silicone membranes in the so-called CellDrum. The cell layers adhere firmly to the membrane and thus transmit the cell forces generated. A CellDrum consists of a cylinder which is sealed from below with a 4 μm thick, biocompatible, functionalized silicone membrane. The weight of cell culture medium bulbs the membrane out downwards. Membrane indentation is measured. When cells contract due to drug action, membrane, cells and medium are lifted upwards. The induced indentation changes allow for lateral drug induced mechanical tension quantification of the micro-tissues. With hiPS-induced (human) Cardiomyocytes (CM) the CellDrum opens new perspectives of individualized cardiac drug testing. Here, monolayers of self-beating hiPS-CMs were grown in CellDrums. Rhythmic contractions of the hiPS-cells induce membrane up-and-down deflections. The recorded cycles allow for single beat amplitude, single beat duration, integration of the single beat amplitude over the beat time and frequency analysis. Dose effects of agonists and antagonists acting on Ca2+ channels were sensitively and highly reproducibly observed. Data were consistent with published reference data as far as they were available. The combination of the CellDrum technology with hiPS-Cardiomyocytes offers a fast, facile and precise system for pharmacological and toxicological studies. It allows new preclinical basic as well as applied research in pharmacolgy and toxicology. Singapore Springer 2018 35 Biological, Physical and Technical Basics of Cell Engineering 978-981-10-7904-7 157 192 10.1007/978-981-10-7904-7_7 http://doi.org/10.1007/978-981-10-7904-7_7 Fachbereich Chemie und Biotechnologie OPUS4-8364 Teil eines Buches Duong, Minh Tuan, duong@fh-aachen.de; Seifarth, Volker, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, ; Staat, Manfred, m.staat@fh-aachen.de Artmann, Gerhard; Temiz Artmann, Aysegül; Zhubanova, Azhar A.; Digel, Ilya Growth Modelling Promoting Mechanical Stimulation of Smooth Muscle Cells of Porcine Tubular Organs in a Fibrin-PVDF Scaffold Reconstructive surgery and tissue replacements like ureters or bladders reconstruction have been recently studied, taking into account growth and remodelling of cells since living cells are capable of growing, adapting, remodelling or degrading and restoring in order to deform and respond to stimuli. Hence, shapes of ureters or bladders and their microstructure change during growth and these changes strongly depend on external stimuli such as training. We present the mechanical stimulation of smooth muscle cells in a tubular fibrin-PVDFA scaffold and the modelling of the growth of tissue by stimuli. To this end, mechanotransduction was performed with a kyphoplasty balloon catheter that was guided through the lumen of the tubular structure. The bursting pressure was examined to compare the stability of the incubated tissue constructs. The results showed the significant changes on tissues with training by increasing the burst pressure as a characteristic mechanical property and the smooth muscle cells were more oriented with uniformly higher density. Besides, the computational growth models also exhibited the accurate tendencies of growth of the cells under different external stimuli. Such models may lead to design standards for the better layered tissue structure in reconstructing of tubular organs characterized as composite materials such as intestines, ureters and arteries. Singapore Springer 2018 23 Biological, Physical and Technical Basics of Cell Engineering 978-981-10-7904-7 209 232 10.1007/978-981-10-7904-7_9 campus https://doi.org/10.1007/978-981-10-7904-7_9 Fachbereich Chemie und Biotechnologie OPUS4-8410 Dissertation Artmann, Gerhard, artmann@fh-aachen.de Monolayer-Photometrie zur Quantifizierung der Form und induzierter Formveränderungen menschlicher Erythrozyten 1988 143 S. : Ill., graph. Darst. Aachen, Techn. Hochsch., Diss., 1988 Fachbereich Medizintechnik und Technomathematik OPUS4-8412 Habilitation Artmann, Gerhard, artmann@fh-aachen.de Methodische und experimentelle Beiträge zur Analyse der Ruheform, der Verformung und der Integrität humaner Erythrozyten 1999 144 S. : Ill., graph. Darst. Ilmenau, Techn. Univ., Habil.-Schr., 1999 Fachbereich Medizintechnik und Technomathematik OPUS4-10891 Wissenschaftlicher Artikel Uysal, Karya, uysal@fh-aachen.de; Firat, Ipek Serat, firat@fh-aachen.de; Creutz, Till, till.creutz@fh-aachen.de; Aydin, Inci Cansu, ; Artmann, Gerhard, artmann@fh-aachen.de; Teusch, Nicole, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de A novel in vitro wound healing assay using free-standing, ultra-thin PDMS membranes Advances in polymer science have significantly increased polymer applications in life sciences. We report the use of free-standing, ultra-thin polydimethylsiloxane (PDMS) membranes, called CellDrum, as cell culture substrates for an in vitro wound model. Dermal fibroblast monolayers from 28- and 88-year-old donors were cultured on CellDrums. By using stainless steel balls, circular cell-free areas were created in the cell layer (wounding). Sinusoidal strain of 1 Hz, 5% strain, was applied to membranes for 30 min in 4 sessions. The gap circumference and closure rate of un-stretched samples (controls) and stretched samples were monitored over 4 days to investigate the effects of donor age and mechanical strain on wound closure. A significant decrease in gap circumference and an increase in gap closure rate were observed in trained samples from younger donors and control samples from older donors. In contrast, a significant decrease in gap closure rate and an increase in wound circumference were observed in the trained samples from older donors. Through these results, we propose the model of a cell monolayer on stretchable CellDrums as a practical tool for wound healing research. The combination of biomechanical cell loading in conjunction with analyses such as gene/protein expression seems promising beyond the scope published here. Basel MDPI 2022 Artikel 22 membranes 2023 This article belongs to the Special Issue "Latest Scientific Discoveries in Polymer Membranes" 13(1) 10.3390/membranes13010022 weltweit https://doi.org/10.3390/membranes13010022 Fachbereich Medizintechnik und Technomathematik OPUS4-9110 Wissenschaftlicher Artikel Akimbekov, N. Sh., ; Zhubanova, A. A., ; Mansurov, Z. A., ; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Use of Carbonized Rise Shell for the local treatment of wounds 2010 5 Eurasian ChemTech Journal 12 2 133 138 10.18321/ectj35 weltweit https://doi.org/10.18321/ectj35 Fachbereich Medizintechnik und Technomathematik OPUS4-10142 Wissenschaftlicher Artikel Uysal, Karya, uysal@fh-aachen.de; Creutz, Till, till.creutz@fh-aachen.de; Firat, Ipek Seda, firat@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Teusch, Nicole, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Bio-functionalized ultra-thin, large-area and waterproof silicone membranes for biomechanical cellular loading and compliance experiments Biocompatibility, flexibility and durability make polydimethylsiloxane (PDMS) membranes top candidates in biomedical applications. CellDrum technology uses large area, <10 µm thin membranes as mechanical stress sensors of thin cell layers. For this to be successful, the properties (thickness, temperature, dust, wrinkles, etc.) must be precisely controlled. The following parameters of membrane fabrication by means of the Floating-on-Water (FoW) method were investigated: (1) PDMS volume, (2) ambient temperature, (3) membrane deflection and (4) membrane mechanical compliance. Significant differences were found between all PDMS volumes and thicknesses tested (p < 0.01). They also differed from the calculated values. At room temperatures between 22 and 26 °C, significant differences in average thickness values were found, as well as a continuous decrease in thicknesses within a 4 °C temperature elevation. No correlation was found between the membrane thickness groups (between 3-4 µm) in terms of deflection and compliance. We successfully present a fabrication method for thin bio-functionalized membranes in conjunction with a four-step quality management system. The results highlight the importance of tight regulation of production parameters through quality control. The use of membranes described here could also become the basis for material testing on thin, viscous layers such as polymers, dyes and adhesives, which goes far beyond biological applications. Basel MDPI 2022 Polymers 14 11 2213 weltweit https://doi.org/10.3390/polym14112213 Fachbereich Medizintechnik und Technomathematik OPUS4-8902 misc Artmann, Gerhard, artmann@fh-aachen.de; Linder, Peter, linder@fh-aachen.de; Bayer, Robin, ; Gossmann, Matthias, Celldrum electrode arrangement for measuring mechanical stress [Patent of invention] The invention pertains to a CellDrum electrode arrangement for measuring mechanical stress, comprising a mechanical holder (1 ) and a non-conductive membrane (4), whereby the membrane (4) is at least partially fixed at its circumference to the mechanical holder (1), keeping it in place when the membrane (4) may bend due to forces acting on the membrane (4), the mechanical holder (1) and the membrane (4) forming a container, whereby the membrane (1) within the container comprises an cell- membrane compound layer or biological material (3) adhered to the deformable membrane 4 which in response to stimulation by an agent may exert mechanical stress to the membrane (4) such that the membrane bending stage changes whereby the container may be filled with an electrolyte, whereby an electric contact (2) is arranged allowing to contact said electrolyte when filled into to the container, whereby within a predefined geometry to the fixing of the membrane (4) an electrode (7) is arranged, whereby the electrode (7) is electrically insulated with respect to the electric contact (2) as well as said electrolyte, whereby mechanical stress due to an agent may be measured as a change in capacitance. Geneva WIPO 2017 18 Seiten Patent auch unter EP3403090, CN109477828, US2019033245 und LU92948 veröffentlicht. weltweit https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170720&DB=&locale=&CC=WO&NR=2017121890A1&KC=A1&ND=1 Fachbereich Luft- und Raumfahrttechnik OPUS4-8946 Konferenzveröffentlichung Bayer, Robin, ; Hescheler, Jürgen, ; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de Staat, Manfred; Erni, Daniel Treating arterial hypertension in a cell culture well Hypertension describes the pathological increase of blood pressure, which is most commonly associated with the increase of vascular wall stiffness [1]. Referring to the "Deutsche Bluthochdruck Liga" this pathology shows a growing trend in our aging society. In order to find novel pharmacological and probably personalized treatments, we want to present a functional approach to study biomechanical properties of a human aortic vascular model. In this method review we will give an overview of recent studies which were carried out with the CellDrum technology [2] and underline the added value to already existing standard procedures known from the field of physiology. Herein described CellDrum technology is a system to measure functional mechanical properties of cell monolayers and thin tissue constructs in-vitro. Additionally, the CellDrum enables to elucidate the mechanical response of cells to pharmacological drugs, toxins and vasoactive agents. Due to its highly flexible polymer support, cells can also be mechanically stimulated by steady and cyclic biaxial stretching. Duisburg Universität Duisburg-Essen 2019 1 3rd YRA MedTech Symposium 2019 : May 24 / 2019 / FH AachenW 978-3-940402-22-6 5 6 10.17185/duepublico/48750 weltweit https://doi.org/10.17185/duepublico/48750 Fachbereich Medizintechnik und Technomathematik OPUS4-9260 Wissenschaftlicher Artikel Bayer, Robin, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Falkenstein, Julia, ; Artmann, Gerhard, artmann@fh-aachen.de; Creutz, Till, ; Hescheler, Jürgen, Mechano-pharmacological testing of L-Type Ca²⁺ channel modulators via human vascular celldrum model Background/Aims: This study aimed to establish a precise and well-defined working model, assessing pharmaceutical effects on vascular smooth muscle cell monolayer in-vitro. It describes various analysis techniques to determine the most suitable to measure the biomechanical impact of vasoactive agents by using CellDrum technology. Methods: The so-called CellDrum technology was applied to analyse the biomechanical properties of confluent human aorta muscle cells (haSMC) in monolayer. The cell generated tensions deviations in the range of a few N/m² are evaluated by the CellDrum technology. This study focuses on the dilative and contractive effects of L-type Ca²⁺ channel agonists and antagonists, respectively. We analyzed the effects of Bay K8644, nifedipine and verapamil. Three different measurement modes were developed and applied to determine the most appropriate analysis technique for the study purpose. These three operation modes are called, particular time mode" (PTM), "long term mode" (LTM) and "real-time mode" (RTM). Results: It was possible to quantify the biomechanical response of haSMCs to the addition of vasoactive agents using CellDrum technology. Due to the supplementation of 100nM Bay K8644, the tension increased approximately 10.6% from initial tension maximum, whereas, the treatment with nifedipine and verapamil caused a significant decrease in cellular tension: 10nM nifedipine decreased the biomechanical stress around 6,5% and 50nM verapamil by 2,8%, compared to the initial tension maximum. Additionally, all tested measurement modes provide similar results while focusing on different analysis parameters. Conclusion: The CellDrum technology allows highly sensitive biomechanical stress measurements of cultured haSMC monolayers. The mechanical stress responses evoked by the application of vasoactive calcium channel modulators were quantified functionally (N/m²). All tested operation modes resulted in equal findings, whereas each mode features operation-related data analysis. Düsseldorf Cell Physiol Biochem Press 2020 12 Cellular Physiology and Biochemistry 54 371 383 10.33594/000000225 weltweit https://doi.org/10.33594/000000225 Fachbereich Medizintechnik und Technomathematik OPUS4-9205 Teil eines Buches Azat, Seitkhan, ; Kerimkulova, Almagul R., ; Mansurov, Zulkhair A., ; Adekenov, Sergazy, ; Artmann, Gerhard, artmann@fh-aachen.de The Use of Fusicoccin as Anticancer Compound The problem of creation and use of sorption materials is of current interest for the practice of the modern medicine and agriculture. Practical importance is production of a biostimulant using a carbon sorbent for a significant increase in productivity, which is very relevant for the regions of Kazakhstan. It is known that a plant phytohormone—fusicoccin—in nanogram concentrations transforms cancer cells to the state of apoptosis. In this regard, there is a scientific practical interest in the development of a highly efficient method for producing fusicoccin from extract of germinated wheat seeds. According to the results of computer modeling, cleaning composite components of fusicoccin using microporous carbon adsorbents not suitable as the size of the molecule of fusicoccin more than micropores and the optimum pore size for purification of constituents of fusicoccin was determined by computer simulation. New York Jenny Stanford Publishing 2020 23 Carbon Nanomaterials in Biomedicine and the Environment 978-0-429-42864-7 149 172 10.1201/9780429428647-8 campus Online lesen IfB - Institut für Bioengineering OPUS4-9574 Bericht Artmann, Gerhard, artmann@fh-aachen.de HPBioforce: Integrierte und automatisierte Screening Plattform eines 96-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an einige um dicken Zell- und Gewebeschichten für die Arzneimittelforschung : gemeinsamer Abschlussbericht der FH Aachen, Hitec Zang GmbH, IKFE Mainz, IKFE Berlin und der Dr. Gerhard Schmidt GmbH zum InnoNet-Projekt ... ; Programm "Förderung von innovativen Netzwerken" (InnoNet) des Bundesministerium für Wirtschaft und Technologie (BMWi) ; Laufzeit: 01.05.2007 bis 31.12.2010 Aachen [u.a.] Technische Informationsbibliothek u. Universitätsbibliothek 2011 Förderkennzeichen BMWi 16IN0536. - Verbund-Nr. 01056220 10.2314/GBV:68757076X weltweit https://doi.org/10.2314/GBV:68757076X Fachbereich Medizintechnik und Technomathematik OPUS4-9575 Bericht Artmann, Gerhard, artmann@fh-aachen.de FhprofUnd EasyBioforce Abschlussbericht : Miniaturisierte, integrierte und automatisierte Screening Plattform eines 36-Well-Hochdurchsatz-Testsystems zur funktionellen Kraftmessung an Zell- und Gewebeschichten für die Arzneimittelforschung : Laufzeit des Vorhabens: 01.03.2007 - 31.12.2010 Aachen Technische Informationsbibliothek u. Universitätsbibliothek 2011 Förderkennzeichen BMBF 1760X07 10.2314/GBV:782964621 weltweit https://doi.org/10.2314/GBV:782964621 Fachbereich Medizintechnik und Technomathematik OPUS4-9577 Bericht Artmann, Gerhard, artmann@fh-aachen.de Escherichia Coli Infektion und Zellschädigung - Wie perfekt wirken Antibiotika? : Abschlussbericht zum Projekt 1703701 Jülich Technische Informationsbibliothek u. Universitätsbibliothek 2004 10.2314/GBV:482527137 weltweit https://doi.org/10.2314/GBV:482527137 Fachbereich Medizintechnik und Technomathematik OPUS4-9578 Bericht Artmann, Gerhard, artmann@fh-aachen.de Plant mutant scanner : Hochdurchsatzscanner zur Charakterisierung von Pflanzenmutanten. Abschlussbericht ; FHprofUnd ; PhytoScan ; Laufzeit des Vorhabens: 01.07.2008 - 30.06.2011 Aachen Technische Informationsbibliothek u. Universitätsbibliothek 2011 Förderkennzeichen BMBF 1736X08 10.2314/GBV:747569150 weltweit https://doi.org/10.2314/GBV:747569150 Fachbereich Medizintechnik und Technomathematik OPUS4-9579 Bericht Artmann, Gerhard, artmann@fh-aachen.de; Bäumler, H., Pharmamikrocontainer mit designgesteuerter Permeabilität als Transporter für ausgewählte Pharmaka. Ein Gemeinschaftsprojekt im Forschungsschwerpunkt "Celluar Engineering" [Laufzeit: 01.09.2000 - 28.02.2002] Jülich FH Aachen 2002 weltweit https://edocs.tib.eu/files/e01fb02/373037341.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-9719 Wissenschaftlicher Artikel Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Kurulgan demirci, Eylem, ; Firat, Ipek Seda, ; Oflaz, Hakan, ; Artmann, Gerhard, artmann@fh-aachen.de Recombinant activated protein C (rhAPC) affects lipopolysaccharide-induced mechanical compliance changes and beat frequency of mESC-derived cardiomyocyte monolayers Köln Wolters Kluwer 2021 SHOCK 10.1097/SHK.0000000000001845 weltweit https://doi.org/10.1097/SHK.0000000000001845 Fachbereich Medizintechnik und Technomathematik OPUS4-4894 Wissenschaftlicher Artikel Bassam, Rasha, bassam@fh-aachen.de; Hescheler, Jürgen, ; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de Effects of spermine NONOate and ATP on the thermal stability of hemoglobin Background Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium environment on the dynamics of thermal unfolding of human hemoglobin (Hb). The effect of these molecules was examined by means of circular dichroism spectrometry (CD) in the temperature range between 25°C and 70°C. The alpha-helical content of buffered hemoglobin samples (0.1 mg/ml) was estimated via ellipticity change measurements at a heating rate of 1°C/min. Results Major results were: 1) spermine NONOate persistently decreased the hemoglobin unfolding temperature T u irrespectively of the Na + /K + environment, 2) ATP instead increased the unfolding temperature by 3°C in both sodium-based and potassium-based buffers and 3) mutual effects of ATP and NO were strongly influenced by particular buffer ionic compositions. Moreover, the presence of potassium facilitated a partial unfolding of alpha-helical structures even at room temperature. Conclusion The obtained data might shed more light on molecular mechanisms and biophysics involved in the regulation of protein activity by small solutes in the cell. London BioMed Central 2012 Art. 16 BMC Biophysics 5 10.1186/2046-1682-5-16 weltweit https://doi.org/10.1186/2046-1682-5-16 Fachbereich Medizintechnik und Technomathematik OPUS4-4784 Wissenschaftlicher Artikel Kurulgan Demirci, Eylem, ; Demirci, Taylan, ; Linder, Peter, linder@fh-aachen.de; Trzewik, Jürgen, ; Gierkowski, Jessica Ricarda, ; Gossmann, Matthias, ; Kayser, Peter, kayser@fh-aachen.de; Porst, Dariusz, porst@fh-aachen.de; Digel, Ilya, digel@fh-aachen.de; Artmann, Gerhard, artmann@fh-aachen.de; Temiz Artmann, Aysegül, a.artmann@fh-aachen.de rhAPC reduces the endothelial cell permeability via a decrease of contractile tensions induced by endothelial cells All cells generate contractile tension. This strain is crucial for mechanically controlling the cell shape, function and survival. In this study, the CellDrum technology quantifying cell's (the cellular) mechanical tension on a pico-scale was used to investigate the effect of lipopolysaccharide (LPS) on human aortic endothelial cell (HAoEC) tension. The LPS effect during gram-negative sepsis on endothelial cells is cell contraction causing endothelium permeability increase. The aim was to finding out whether recombinant activated protein C (rhAPC) would reverse the endothelial cell response in an in-vitro sepsis model. In this study, the established in-vitro sepsis model was confirmed by interleukin 6 (IL-6) levels at the proteomic and genomic levels by ELISA, real time-PCR and reactive oxygen species (ROS) activation by florescence staining. The thrombin cellular contraction effect on endothelial cells was used as a positive control when the CellDrum technology was applied. Additionally, the Ras homolog gene family, member A (RhoA) mRNA expression level was checked by real time-PCR to support contractile tension results. According to contractile tension results, the mechanical predominance of actin stress fibers was a reason of the increased endothelial contractile tension leading to enhanced endothelium contractility and thus permeability enhancement. The originality of this data supports firstly the basic measurement principles of the CellDrum technology and secondly that rhAPC has a beneficial effect on sepsis influenced cellular tension. The technology presented here is promising for future high-throughput cellular tension analysis that will help identify pathological contractile tension responses of cells and prove further cell in-vitro models. Amsterdam Elsevier 2012 7 Journal of Bioscience and Bioengineering 113 2 212 219 10.1016/j.jbiosc.2012.03.019 campus https://doi.org/10.1016/j.jbiosc.2012.03.019 Fachbereich Medizintechnik und Technomathematik