Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-5150 Wissenschaftlicher Artikel Reisert, Steffen, reisert@fh-aachen.de; Schneider, Benno, benno.schneider@fh-aachen.de; Geissler, Hanno, ; Gompel, Matthias van, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Multi-sensor chip for the investigation of different types of metal oxides for the detection of H2O2 in the ppm range In this work, a multi-sensor chip for the investigation of the sensing properties of different types of metal oxides towards hydrogen peroxide in the ppm range is presented. The fabrication process and physical characterization of the multi-sensor chip are described. Pure SnO2 and WO3 as well as Pd- and Pt-doped SnO2 films are characterized in terms of their sensitivity to H2O2. The sensing films have been prepared by drop-coating of water-dispensed nano-powders. A physical characterization, including scanning electron microscopy and X-ray diffraction analysis of the deposited metal-oxide films, was done. From the measurements in hydrogen peroxide atmosphere, it could be shown, that all of the tested metal oxide films are suitable for the detection of H2O2 in the ppm range. The highest sensitivity and reproducibility was achieved using Pt-doped SnO2. Calibration plot of a SnO2, WO3, Pt-, and Pd-doped SnO2 gas sensor for H2O2 concentrations in the ppm range. Weinheim Wiley 2013 6 physica status solidi (a) Vol. 210 Iss. 5 898 904 campus http://dx.doi.org/10.1002/pssa.201200930 Fachbereich Medizintechnik und Technomathematik OPUS4-3781 Wissenschaftlicher Artikel Abouzar, Maryam H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Razavi, Arash, ; Besmehn, Astrid, ; Bijnens, Nathalie, ; Williams, Oliver A., ; Haenen, Ken, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Penicillin detection with nanocrystalline-diamond field-effect sensor 2008 4 physica status solidi (a). 205 (2008), H. 9 1862-6319 Special Issue: Hasselt Diamond Workshop 2008 - SBDD XIII 2141 2145 campus http://dx.doi.org/10.1002/pssa.200879713 Fachbereich Medizintechnik und Technomathematik OPUS4-3785 Wissenschaftlicher Artikel Poghossian, Arshak, poghossian@fh-aachen.de; Abouzar, Maryam H., ; Christiaens, P., ; Williams, O. A., ; Haenen, K., ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Sensing charged macromolecules with nanocrystalline diamond-based field-effect capacitive sensors 2008 4 Journal of Contemporary Physics. 43 (2008), H. 2 1934-9378 Armenian Academy of Sciences 77 81 campus http://dx.doi.org/10.1007/s11958-008-2006-x Fachbereich Medizintechnik und Technomathematik OPUS4-3862 Wissenschaftlicher Artikel Schöning, Michael Josef, schoening@fh-aachen.de; Doll, Theodor, ; Wagner, Patrick, Preface / Doll, Theodor ; Wagner, Patrick ; Schöning, Michael J. 2009 1 physica status solidi (a) . 206 (2009), H. 3 1862-6319 Special Issue: Engineering of Functional Interfaces (EnFI 08) 389 390 campus http://dx.doi.org/10.1002/pssa.200880488 Fachbereich Medizintechnik und Technomathematik OPUS4-3976 Wissenschaftlicher Artikel Bäcker, Matthias, baecker@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Abouzar, Maryam H., ; Wenmackers, Sylvia, ; Janssens, Stoffel D., ; Haenen, Ken, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Capacitive field-effect (bio-)chemical sensors based on nanocrystalline diamond films 2010 5 Diamond Electronics and Bioelectronics — Fundamentals to Applications III, edited by P. Bergonzo, [u.a.] MRS Proceedings Volume 1203 paper 1203-J17-31 ; Mater. Res. Soc. Sympos. Proc. Vol 1203 (2010) ; Materials Research Society 1 6 bezahl http://dx.doi.org/10.1557/PROC-1203-J17-31 Fachbereich Medizintechnik und Technomathematik OPUS4-3958 Wissenschaftlicher Artikel Bäcker, Matthias, baecker@fh-aachen.de; Beging, Stefan, beging@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wang, J., ; Zang, Werner, zang@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Concept for a solid-state multi-parameter sensor system for cell-culture monitoring Amsterdam Elsevier 2009 5 Electrochimica Acta. 54 (2009), H. 25 Sp. Iss. SI 0013-4686 6107 6112 campus http://dx.doi.org/10.1016/j.electacta.2009.02.091 Fachbereich Chemie und Biotechnologie OPUS4-4375 Wissenschaftlicher Artikel Gun, Jenny, ; Gutkin, Vitaly, ; Lev, Ovadia, ; Boyen, Hans-Gerd, ; Saitner, Marc, ; Wagner, Patrick, ; Olieslaeger, Marc D´, ; Abouzar, Maryam H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Tracing gold nanoparticle charge by electrolyte-insulator-semiconductor devices Washington, DC American Cemical Society 2011 6 Journal of Physical Chemistry C. 115 (2011), H. 11 1932-7455 4439 4445 campus http://dx.doi.org/10.1021/jp109886s Fachbereich Medizintechnik und Technomathematik OPUS4-4357 Wissenschaftlicher Artikel Bohrn, Ulrich, ; Stütz, Evamaria, ; Fleischer, Maximilian, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, Eukaryotic cell lines as a sensitive layer for direct monitoring of carbon monoxide Weinheim Wiley 2011 5 Physica status solidi (a) : applications and material science. 208 (2011), H. 6 1862-6319 1345 1350 campus http://dx.doi.org/10.1002/pssa.201000924 Fachbereich Medizintechnik und Technomathematik OPUS4-4358 Wissenschaftlicher Artikel Bäcker, Matthias, baecker@fh-aachen.de; Pouyeshman, S., ; Schnitzler, Thomas, schnitzler@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Patrick, ; Biselli, Manfred, biselli@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de A silicon-based multi-sensor chip for monitoring of fermentation processes Weinheim Wiley 2011 5 Physica status solidi (a) : applications and material science. 208 (2011), H. 6 1862-6319 1364 1369 campus http://dx.doi.org/10.1002/pssa.201001139 Fachbereich Medizintechnik und Technomathematik OPUS4-4366 Wissenschaftlicher Artikel Reisert, Steffen, reisert@fh-aachen.de; Geissler, Hanno, ; Flörke, Rudolf, ; Näther, Niko, naether@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Towards a multi-sensor system for the evaluation of aseptic processes employing hydrogen peroxide vapour (H2O2) Weinheim Wiley 2011 5 Physica status solidi (a) : applications and material science. 208 (2011), H. 6 1862-6319 1351 1356 campus http://dx.doi.org/10.1002/pssa.201001138 Fachbereich Medizintechnik und Technomathematik OPUS4-4613 Wissenschaftlicher Artikel Huck, Christina, huck@fh-aachen.de; Jolly, Christina, ; Wagner, Patrick, ; Poghossian, Arshak, poghossian@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de One-chip integrated dual amperometric/field-effect sensor for the detection of dissolved hydrogen Amsterdam Elsevier 2011 3 Procedia Engineering. 25 (2011) 1877-7058 EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece 1161 1164 campus http://dx.doi.org/10.1016/j.proeng.2011.12.286 Fachbereich Medizintechnik und Technomathematik OPUS4-4677 Wissenschaftlicher Artikel Schusser, Sebastian, schusser@fh-aachen.de; Leinhos, Marcel, leinhos@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Biopolymer-degradation monitoring by chip-­based impedance spectroscopy technique - 2012 0 Nanoscale Science and Technology (NS&T´12) : Proceedings Book Humboldt Kolleg <2012, Tunisia> ; Tunisia, 17-19 March, 2012 / ed. by Michael J. Schöning ; Adnane Abdelghani Proceedings of the 2nd Humboldt Kolleg, Hammamet, Tunisia, 17-19 March, 2012 Organizer: Alexander von Humboldt Stiftung, Germany. pdf 184 p. 47 47 weltweit http://opus.bibliothek.fh-aachen.de/opus/volltexte/2012/354/ Fachbereich Medizintechnik und Technomathematik OPUS4-4679 Wissenschaftlicher Artikel Bäcker, Matthias, baecker@fh-aachen.de; Rakowski, D., ; Poghossian, Arshak, poghossian@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis Amsterdam Elsevier 2013 5 Journal of Biotechnology. Vol. 163 (2012), iss. 4 Vol. 163 Iss. 4 371 376 campus http://dx.doi.org/10.1016/j.jbiotec.2012.03.014 Fachbereich Chemie und Biotechnologie OPUS4-4666 Wissenschaftlicher Artikel Grinsven, Bart van, ; Bon, Natalie vanden, ; Strauven, Hannelore, ; Grieten, Lars, ; Murib, Mohammed, ; Jiménez Monroy, Kathia L., ; Janssens, Stoffel D., ; Haenen, Ken, ; Schöning, Michael Josef, schoening@fh-aachen.de; Vermeeren, Veronique, ; Ameloot, Marcel, ; Michiels, Luc, ; Thoelen, Ronald, ; Ceuninck, Ward de, ; Wagner, Patrick, Heat-Transfer Resistance at Solid-Liquid Interfaces: A Tool for The Detection of Single Nucleotide Polymorphisms in DNA. 2012 9 ACS Nano. 6 (2012), H. 3 1936-086X 2712 2721 campus http://dx.doi.org/10.1021/nn300147e Fachbereich Medizintechnik und Technomathematik OPUS4-4857 Wissenschaftlicher Artikel Bohrn, Ulrich, ; Stütz, Evamaria, ; Fleischer, Maximilian, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, Using a cell-based gas biosensor for investigation of adverse effects of acetone vapors in vitro Amsterdam Elsevier 2013 7 Biosensors and Bioelectronics. 40 (2013), H. 1 0956-5663 393 400 campus http://dx.doi.org/10.1016/j.bios.2012.08.029 Fachbereich Medizintechnik und Technomathematik OPUS4-4929 Wissenschaftlicher Artikel Murib, Mohammed S., ; Tran, Anh Quang, ; Ceuninck, Ward de, ; Schöning, Michael Josef, schoening@fh-aachen.de; Nesladek, Milos, ; Serpengüzel, Ali, ; Wagner, Patrick, Analysis of an optical biosensor based on elastic light scattering from diamond-, glass-, and sapphire microspheres Deoxyribonucleic acid (DNA) and protein recognition are now standard tools in biology. In addition, the special optical properties of microsphere resonators expressed by the high quality factor (Q-factor) of whispering gallery modes (WGMs) or morphology dependent resonances (MDRs) have attracted the attention of the biophotonic community. Microsphere-based biosensors are considered as powerful candidates to achieve label-free recognition of single molecules due to the high sensitivity of their WGMs. When the microsphere surface is modified with biomolecules, the effective refractive index and the effective size of the microsphere change resulting in a resonant wavelength shift. The transverse electric (TE) and the transverse magnetic (TM) elastic light scattering intensity of electromagnetic waves at 600 and 1400 nm are numerically calculated for DNA and unspecific binding of proteins to the microsphere surface. The effect of changing the optical properties was studied for diamond (refractive index 2.34), glass (refractive index 1.50), and sapphire (refractive index 1.75) microspheres with a 50 µm radius. The mode spacing, the linewidth of WGMs, and the shift of resonant wavelength due to the change in radius and refractive index, were analyzed by numerical simulations. Preliminary results of unspecific binding of biomolecules are presented. The calculated shift in WGMs can be used for biomolecules detection. Weinheim Wiley-VCH 2012 6 Physica Status Solidi A 209 Special Issue: "Fundamentals and Applications of Diamond" 9 1804 1810 10.1002/pssa.201100795 campus https:/doi.org/10.1002/pssa.201100795 Fachbereich Medizintechnik und Technomathematik OPUS4-4940 Wissenschaftlicher Artikel Huck, Christina, huck@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Combined amperometric/field-effect sensor for the detection of dissolved hydrogen Real-time and reliable monitoring of the biogas process is crucial for a stable and efficient operation of biogas production in order to avoid digester breakdowns. The concentration of dissolved hydrogen (H₂) represents one of the key parameters for biogas process control. In this work, a one-chip integrated combined amperometric/field-effect sensor for monitoring the dissolved H₂ concentration has been developed for biogas applications. The combination of two different transducer principles might allow a more accurate and reliable measurement of dissolved H₂ as an early warning indicator of digester failures. The feasibility of the approach has been demonstrated by simultaneous amperometric/field-effect measurements of dissolved H₂ concentrations in electrolyte solutions. Both, the amperometric and the field-effect transducer show a linear response behaviour in the H₂ concentration range from 0.1 to 3% (v/v) with a slope of 198.4 ± 13.7 nA/% (v/v) and 14.9 ± 0.5 mV/% (v/v), respectively. Amsterdam Elsevier 2012 5 Sensors and actuators B: Chemical 187 Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" 168 173 10.1016/j.snb.2012.10.050 campus https://doi.org/10.1016/j.snb.2012.10.050 Fachbereich Medizintechnik und Technomathematik OPUS4-5317 Wissenschaftlicher Artikel Schusser, Sebastian, schusser@fh-aachen.de; Leinhos, Marcel, leinhos@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Impedance spectroscopy: A tool for real-time in situ monitoring of the degradation of biopolymers Weinheim Wiley 2013 5 Physica Status Solidi (A). Vol. 210 (2013), iss. 5 905 910 campus http://onlinelibrary.wiley.com/doi/10.1002/pssa.201200941/pdf Fachbereich Medizintechnik und Technomathematik OPUS4-5320 Wissenschaftlicher Artikel Huck, Christina, huck@fh-aachen.de; Schiffels, Johannes, schiffels@fh-aachen.de; Herrera, Cony N., ; Schelden, Maximilian, ; Selmer, Thorsten, selmer@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Baumann, Marcus, rektor@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Metabolic responses of Escherichia coli upon glucose pulses captured by a capacitive field-effect sensor Weinheim Wiley-VCH 2013 5 Physica Status Solidi (A). Vol. 210 (2013), iss. 5 926 931 campus http://onlinelibrary.wiley.com/doi/10.1002/pssa.201200900/pdf Fachbereich Chemie und Biotechnologie OPUS4-5321 Wissenschaftlicher Artikel Murib, M. S., ; Grinsven, B. van, ; Grieten, L., ; Janssens, S. D., ; Vermeeren, V., ; Eersels, K., ; Broeders, J., ; Ameloot, M., ; Michiels, L., ; Ceuninck, W. De, ; Haenen, K., ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, Electronic monitoring of chemical DNA denaturation on nanocrystalline diamond electrodes with different molarities and flow rates Berlin Wiley-VCH 2013 6 Physica Status Solidi (A). Vol. 210 (2013), iss. 5 911 917 campus http://onlinelibrary.wiley.com/doi/10.1002/pssa.201200934/pdf Fachbereich Medizintechnik und Technomathematik OPUS4-5575 Wissenschaftlicher Artikel Bohrn, Ulrich, ; Mucha, Andreas, ; Werner, Frederik, f.werner@fh-aachen.de; Trattner, Barbara, ; Bäcker, Matthias, baecker@fh-aachen.de; Krumbe, Christoph, ; Schienle, Meinrad, ; Stütz, Evamaria, ; Schmitt-Landsiedel, Doris, ; Fleischer, Maximilian, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de A critical comparison of cell-based sensor systems for the detection of Cr (VI) in aquatic environment Amsterdam Elsevier 2013 7 Sensors and actuators. B: Chemical Vol. 182 58 65 campus http://www.sciencedirect.com/science/article/pii/S0925400513002402 Fachbereich Medizintechnik und Technomathematik OPUS4-5995 Wissenschaftlicher Artikel Reisert, Steffen, reisert@fh-aachen.de; Geissler, Hanno, ; Flörke, Rudolf, ; Weiler, Christian, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Characterisation of aseptic sterilisation processes using an electronic nose Genève Inderscience Enterprises 2013 14 International journal of nanotechnology Vol. 10 No. 5-7 470 484 bezahl http://dx.doi.org/10.1504/IJNT.2013.053517 Fachbereich Medizintechnik und Technomathematik OPUS4-6088 misc Ingebrandt, Sven, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Engineering of functional interfaces / guest eds. Sven Ingebrandt ; Patrick Wagner ; Michael J. Schöning 2013 Physica Status Solidi (A) Vol. 210 Iss. 5 845 campus http://dx.doi.org/10.1002/pssa.201322718 Fachbereich Medizintechnik und Technomathematik OPUS4-6112 Konferenzveröffentlichung Schusser, Sebastian, schusser@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Leinhos, Marcel, leinhos@fh-aachen.de; Krischer, M., ; Wenzel, L., ; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Sensorkonzept zur in vitro Echtzeitmessung des Degradationsverhaltens von biodegradierbaren Biopolymeren 2013 3 11. Dresdner Sensor-Symposium : 9.-11.12.2013 978-3-9813484-5-3 174 177 weltweit http://dx.doi.org/10.5162/11dss2013/A11 Fachbereich Medizintechnik und Technomathematik OPUS4-6114 Konferenzveröffentlichung Oberländer, Jan, oberlaender@fh-aachen.de; Reisert, Steffen, reisert@fh-aachen.de; Kirchner, Patrick, kirchner@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Kalorimetrische Gassensoren zur H2O2-Detektion in aseptischen Sterilisationsprozessen 2013 4 11. Dresdner Sensor-Symposium : 9.-11.12.2013 978-3-9813484-5-3 234 238 weltweit http://dx.doi.org/10.5162/11dss2013/B7 Fachbereich Medizintechnik und Technomathematik OPUS4-6115 Konferenzveröffentlichung Huck, Christina, huck@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Zander, W., ; Schubert, J., ; Sukoyan, L. H., ; Begoyan, V., ; Buniatyan, V. V., ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Chemische Sensoren mit Bariumstrontiumtitanat als funktionelle Schicht zur Multiparameterdetektion 2013 4 11. Dresdner Sensor-Symposium : 9.-11.12.2013 978-3-9813484-5-3 368 372 weltweit http://dx.doi.org/10.5162/11dss2013/F15 Fachbereich Medizintechnik und Technomathematik OPUS4-6409 Wissenschaftlicher Artikel Huck, Christina, huck@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Kerroumi, Iman, ; Schusser, Sebastian, schusser@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Zander, Willi, ; Schubert, Jürgen, ; Buniatyan, Vahe V., ; Martirosyan, Norayr W., ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Multiparameter sensor chip with Barium Strontium Titanate as multipurpose material It is well known that biochemical and biotechnological processes are strongly dependent and affected by a variety of physico-chemical parameters such as pH value, temperature, pressure and electrolyte conductivity. Therefore, these quantities have to be monitored or controlled in order to guarantee a stable process operation, optimization and high yield. In this work, a sensor chip for the multiparameter detection of three physico-chemical parameters such as electrolyte conductivity, pH and temperature is realized using barium strontium titanate (BST) as multipurpose material. The chip integrates a capacitively coupled four-electrode electrolyte-conductivity sensor, a capacitive field-effect pH sensor and a thin-film Pt-temperature sensor. Due to the multifunctional properties of BST, it is utilized as final outermost coating layer of the processed sensor chip and serves as passivation and protection layer as well as pH-sensitive transducer material at the same time. The results of testing of the individual sensors of the developed multiparameter sensor chip are presented. In addition, a quasi-simultaneous multiparameter characterization of the sensor chip in buffer solutions with different pH value and electrolyte conductivity is performed. To study the sensor behavior and the suitability of BST as multifunctional material under harsh environmental conditions, the sensor chip was exemplarily tested in a biogas digestate. Weinheim Wiley-VCH 2014 7 Electroanalysis 26 5 980 987 10.1002/elan.201400076 campus https://doi.org/10.1002/elan.201400076 Fachbereich Medizintechnik und Technomathematik OPUS4-6502 Wissenschaftlicher Artikel Wagner, Patrick, ; Doll, Theodor, ; Schöning, Michael Josef, schoening@fh-aachen.de Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Schöning (eds.) Weinheim Wiley-VCH 2014 0 Physica status solidi (A) : Applications and materials science 211 6 1339 1339 10.1002/pssa.201470241 campus https://doi.org/10.1002/pssa.201470241 Fachbereich Medizintechnik und Technomathematik OPUS4-6676 Wissenschaftlicher Artikel Murib, Mohammed Sharif, ; Yeap, Weng-Siang, ; Martens, Daan, ; Bienstman, Peter, ; Ceuninck, Ward de, ; Grinsven, Bart van, ; Schöning, Michael Josef, schoening@fh-aachen.de; Michiels, Luc, ; Haenen, Ken, ; Ameloot, Marcel, ; Serpengüzel, Ali, ; Wagner, Patrick, Photonic detection and characterization of DNA using sapphire microspheres A microcavity-based deoxyribonucleic acid (DNA) optical biosensor is demonstrated for the first time using synthetic sapphire for the optical cavity. Transmitted and elastic scattering intensity at 1510 nm are analyzed from a sapphire microsphere (radius 500  μm, refractive index 1.77) on an optical fiber half coupler. The 0.43 nm angular mode spacing of the resonances correlates well with the optical size of the sapphire sphere. Probe DNA consisting of a 36-mer fragment was covalently immobilized on a sapphire microsphere and hybridized with a 29-mer target DNA. Whispering gallery modes (WGMs) were monitored before the sapphire was functionalized with DNA and after it was functionalized with single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). The shift in WGMs from the surface modification with DNA was measured and correlated well with the estimated thickness of the add-on DNA layer. It is shown that ssDNA is more uniformly oriented on the sapphire surface than dsDNA. In addition, it is shown that functionalization of the sapphire spherical surface with DNA does not affect the quality factor (Q≈104) of the sapphire microspheres. The use of sapphire is especially interesting because this material is chemically resilient, biocompatible, and widely used for medical implants. Bellingham SPIE 2014 Journal of biomedical optics 19 9 097006 10.1117/1.JBO.19.9.097006 bezahl https://doi.org/10.1117/1.JBO.19.9.097006 Fachbereich Medizintechnik und Technomathematik OPUS4-6779 Wissenschaftlicher Artikel Murib, M. S., ; Yeap, W. S., ; Martens, D., ; Liu, X., ; Bienstman, P., ; Fahlman, M., ; Schöning, Michael Josef, schoening@fh-aachen.de; Michiels, L., ; Haenen, K., ; Serpengüzel, A., ; Wagner, Patrick, Photonic studies on polymer-coated sapphire-spheres : a model system for biological ligands Amsterdam Elsevier 2015 7 Sensors and actuators A: Physical 222 212 219 campus http://dx.doi.org/10.1016/j.sna.2014.11.024 Fachbereich Medizintechnik und Technomathematik OPUS4-6832 Konferenzveröffentlichung Bohrn, Ulrich, ; Mucha, Andreas, ; Werner, Frederik, f.werner@fh-aachen.de; Stütz, Evamaria, ; Bäcker, Matthias, baecker@fh-aachen.de; Krumbe, Christoph, ; Schienle, Meinrad, ; Fleischer, Maximilian, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Detection of toxic chromium species in water using cellbased sensor systems 2012 3 978-3-9813484-2-2 14th International Meeting on Chemical Sensors - IMCS 2012 1364 1367 10.5162/IMCS2012/P2.1.14 weltweit Fachbereich Medizintechnik und Technomathematik OPUS4-6835 Konferenzveröffentlichung Bohrn, Ulrich, ; Stütz, Evamaria, ; Fleischer, Maximilian, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, Living cell-based gas sensor system for the detection of acetone in air 2012 3 978-3-9813484-2-2 14th International Meeting on Chemical Sensors - IMCS 2012 269 272 10.5162/IMCS2012/3.2.3 weltweit Fachbereich Medizintechnik und Technomathematik OPUS4-6837 Konferenzveröffentlichung Huck, Christina, huck@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Bifunktionaler Sensorchip für den Nachweis von Gelöstwasserstoff 2011 3 978-3942710-53-4 10. Dresdner Sensor-Symposium 2011 325 328 10.5162/10dss2011/16.10 weltweit Fachbereich Medizintechnik und Technomathematik OPUS4-7294 Wissenschaftlicher Artikel Delle, Lotta E., ; Huck, Christina, huck@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Müller, Frank, ; Grandthyll, Samuel, ; Jacobs, Karin, ; Lilischkis, Rainer, ; Vu, Xuan T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, ; Thoelen, Roland, ; Weil, Maryam, ; Ingebrandt, Sven, Impedimetric immunosensor for the detection of histamine based on reduced graphene oxide Weinheim Wiley 2015 7 Physica status solidi (a) 212 6 1327 1334 10.1002/pssa.201431863 campus https://doi.org/10.1002/pssa.201431863 Fachbereich Medizintechnik und Technomathematik OPUS4-7293 Wissenschaftlicher Artikel Warmer, Johannes, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de; Kaul, Peter, Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors Weinheim Wiley-VCH 2015 9 Physica status solidi (a) 212 6 1289 1298 10.1002/pssa.201431882 campus https://doi.org/10.1002/pssa.201431882 Fachbereich Medizintechnik und Technomathematik OPUS4-7416 Wissenschaftlicher Artikel Oberländer, Jan, oberlaender@fh-aachen.de; Jildeh, Zaid B., ; Kirchner, Patrick, kirchner@fh-aachen.de; Wendeler, Luisa, ; Bromm, Alexander, ; Iken, Heiko, iken@fh-aachen.de; Wagner, Patrick, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Study of Interdigitated Electrode Arrays Using Experiments and Finite Element Models for the Evaluation of Sterilization Processes Basel MDPI 2015 12 Sensors 15 10 26115 26127 10.3390/s151026115 Fachbereich Medizintechnik und Technomathematik OPUS4-7590 Konferenzveröffentlichung Oberländer, Jan, oberlaender@fh-aachen.de; Jildeh, Zaid B., ; Kirchner, Patrick, kirchner@fh-aachen.de; Wendeler, Luisa, ; Bromm, Alexander, ; Iken, Heiko, iken@fh-aachen.de; Wagner, Patrick, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Experimental and numerical evaluation of interdigitated electrode array for monitoring gaseous sterilization processes 2015 5 12. Dresdner Sensor-Symposium 2015 163 168 10.5162/12dss2015/P3.11 Fachbereich Medizintechnik und Technomathematik OPUS4-7591 Wissenschaftlicher Artikel Schusser, Sebastian, schusser@fh-aachen.de; Krischer, Maximillian, ; Bäcker, Matthias, ; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Monitoring of the Enzymatically Catalyzed Degradation of Biodegradable Polymers by Means of Capacitive Field-Effect Sensors Washington, DC ACS Publications 2015 6 Analytical Chemistry 87 13 6607 6613 10.1021/acs.analchem.5b00617 Fachbereich Medizintechnik und Technomathematik OPUS4-7729 Wissenschaftlicher Artikel Dantism, Shahriar, Dantism@fh-aachen.de; Takenaga, Shoko, ; Wagner, Patrick, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Determination of the extracellular acidification of Escherichia coli K12 with a multi-​chamber-​based LAPS system On-line monitoring of the metabolic activity of microorganisms involved in intermediate stages of biogas production plays an important role to avoid undesirable "down times" during the biogas production. In order to control this process, an on-chip differential measuring system based on the light-addressable potentiometric sensor (LAPS) principle combined with a 3D-printed multi-chamber structure has been realized. As a test microorganism, Escherichia coli K12 (E. coli K12) were used for cell-based measurements. Multi-chamber structures were developed to determine the metabolic activity of E. coli K12 in suspension for a different number of cells, responding to the addition of a constant or variable amount of glucose concentrations, enabling differential and simultaneous measurements. Weinheim Wiley-VCH 2016 6 Physica status solidi (a) 213 6 1479 1485 10.1002/pssa.201533043 campus https://doi.org/10.1002/pssa.201533043 Fachbereich Medizintechnik und Technomathematik OPUS4-7801 Wissenschaftlicher Artikel Doll, Theodor, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Engineering of functional interfaces / Theodor Doll ; Torsten Wagner ; Patrick Wagner ; Michael J. Schöning (eds.) Weinheim Wiley-VCH 2016 1 Physica status solidi (a) 213 6 1393 1394 10.1002/pssa.201670641 campus https://doi.org/10.1002/pssa.201670641 Fachbereich Medizintechnik und Technomathematik OPUS4-8139 Wissenschaftlicher Artikel Dantism, Shahriar, Dantism@fh-aachen.de; Takenaga, Shoko, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Differential imaging of the metabolism of bacteria and eukaryotic cells based on light-addressable potentiometric sensors Amsterdam Elsevier 2017 7 Electrochimica Acta 246 234 241 10.1016/j.electacta.2017.05.196 Fachbereich Medizintechnik und Technomathematik OPUS4-8423 Wissenschaftlicher Artikel Dantism, Shahriar, Dantism@fh-aachen.de; Röhlen, Desiree, roehlen@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Optimization of Cell-Based Multi-Chamber LAPS Measurements Utilizing FPGA-Controlled Laser-Diode Modules A light-addressable potentiometric sensor (LAPS) is a field-effect-based potentiometric device, which detects concentration changes of an analyte solution on the sensor surface in a spatially resolved way. It uses a light source to generate electron-hole pairs inside the semiconductor, which are separated in the depletion region due to an applied bias voltage across the sensor structure and hence, a surface-potential-dependent photocurrent can be read out. However, depending on the beam angle of the light source, scattering effects can occur, which influence the recorded signal in LAPS-based differential measurements. To solve this problem, a novel illumination unit based on a field programmable gate array (FPGA) consisting of 16 small-sized tunable infrared laser-diode modules (LDMs) is developed. Due to the improved focus of the LDMs with a beam angle of only 2 mrad, undesirable scattering effects are minimized. Escherichia coli (E. coli) K12 bacteria are used as a test microorganism to study the extracellular acidification on the sensor surface. Furthermore, a salt bridge chamber is built up and integrated with the LAPS system enabling multi-chamber differential measurements with a single Ag/AgCl reference electrode. Weinheim Wiley-VCH 2018 physica status solidi a : applications and materials sciences 215 15 Article number 1800058 10.1002/pssa.201800058 campus https://doi.org/10.1002/pssa.201800058 Fachbereich Medizintechnik und Technomathematik OPUS4-8428 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Scheja, Sabrina, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, ; Wagner, Torsten, torsten.wagner@fh-aachen.de Electrochemical Evaluation of Light-Addressable Electrodes Based on TiO2 for the Integration in Lab-on-Chip Systems In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol-gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated. Weinheim Wiley-VCH 2018 physica status solidi a : applications and materials sciences 215 15 Article number 1800150 10.1002/pssa.201800150 campus https://doi.org/10.1002/pssa.201800150 Fachbereich Medizintechnik und Technomathematik OPUS4-10928 Wissenschaftlicher Artikel Karschuck, Tobias, karschuck@fh-aachen.de; Schmidt, Stefan, s.schmidt@fh-aachen.de; Achtsnicht, Stefan, achtsnicht@fh-aachen.de; Poghossian, Arshak, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Multiplexing system for automated characterization of a capacitive field-effect sensor array In comparison to single-analyte devices, multiplexed systems for a multianalyte detection offer a reduced assay time and sample volume, low cost, and high throughput. Herein, a multiplexing platform for an automated quasi-simultaneous characterization of multiple (up to 16) capacitive field-effect sensors by the capacitive-voltage (C-V) and the constant-capacitance (ConCap) mode is presented. The sensors are mounted in a newly designed multicell arrangement with one common reference electrode and are electrically connected to the impedance analyzer via the base station. A Python script for the automated characterization of the sensors executes the user-defined measurement protocol. The developed multiplexing system is tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles. Weinheim Wiley-VCH 2023 7 Seiten Physica Status Solidi A 220 Corresponding author: Michael Josef Schöning 22 10.1002/pssa.202300265 weltweit https://doi.org/10.1002/pssa.202300265 Fachbereich Medizintechnik und Technomathematik OPUS4-8906 Wissenschaftlicher Artikel Cornelis, Peter, ; Givanoudi, Stella, ; Yongabi, Derick, ; Iken, Heiko, iken@fh-aachen.de; Duwé, Sam, ; Deschaume, Olivier, ; Robbens, Johan, ; Dedecker, Peter, ; Bartic, Carmen, ; Wübbenhorst, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de; Heyndrickx, Marc, ; Wagner, Patrick, Sensitive and specific detection of E. coli using biomimetic receptors in combination with a modified heat-transfer method Amsterdam Elsevier 2019 8 Biosensors and Bioelectronics 136 97 105 10.1016/j.bios.2019.04.026 bezahl https://doi.org/10.1016/j.bios.2019.04.026 Fachbereich Medizintechnik und Technomathematik OPUS4-9258 Wissenschaftlicher Artikel Dantism, Shahriar, Dantism@fh-aachen.de; Röhlen, Desiree, roehlen@fh-aachen.de; Dahmen, Markus, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de LAPS-based monitoring of metabolic responses of bacterial cultures in a paper fermentation broth As an alternative renewable energy source, methane production in biogas plants is gaining more and more attention. Biomass in a bioreactor contains different types of microorganisms, which should be considered in terms of process-stability control. Metabolically inactive microorganisms within the fermentation process can lead to undesirable, time-consuming and cost-intensive interventions. Hence, monitoring of the cellular metabolism of bacterial populations in a fermentation broth is crucial to improve the biogas production, operation efficiency, and sustainability. In this work, the extracellular acidification of bacteria in a paper-fermentation broth is monitored after glucose uptake, utilizing a differential light-addressable potentiometric sensor (LAPS) system. The LAPS system is loaded with three different model microorganisms (Escherichia coli, Corynebacterium glutamicum, and Lactobacillus brevis) and the effect of the fermentation broth at different process stages on the metabolism of these bacteria is studied. In this way, different signal patterns related to the metabolic response of microorganisms can be identified. By means of calibration curves after glucose uptake, the overall extracellular acidification of bacterial populations within the fermentation process can be evaluated. Amsterdam Elsevier 2020 Sensors and Actuators B: Chemical 320 Art. 128232 10.1016/j.snb.2020.128232 bezahl https://doi.org/10.1016/j.snb.2020.128232 Fachbereich Medizintechnik und Technomathematik OPUS4-9498 Wissenschaftlicher Artikel Givanoudi, Stella, ; Cornelis, Peter, ; Rasschaert, Geertrui, ; Wackers, Gideon, ; Iken, Heiko, iken@fh-aachen.de; Rolka, David, d.rolka@fh-aachen.de; Yongabi, Derick, ; Robbens, Johan, ; Schöning, Michael Josef, schoening@fh-aachen.de; Heyndrickx, Marc, ; Wagner, Patrick, Selective Campylobacter detection and quantification in poultry: A sensor tool for detecting the cause of a common zoonosis at its source Amsterdam Elsevier 2021 Sensors and Actuators B: Chemical In Press, Journal Pre-proof Article 129484 10.1016/j.snb.2021.129484 bezahl https://doi.org/10.1016/j.snb.2021.129484 Fachbereich Medizintechnik und Technomathematik OPUS4-10456 Wissenschaftlicher Artikel Poghossian, Arshak, ; Karschuck, Tobias, karschuck@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Field-Effect Capacitors Decorated with Ligand-Stabilized Gold Nanoparticles: Modeling and Experiments Nanoparticles are recognized as highly attractive tunable materials for designing field-effect biosensors with enhanced performance. In this work, we present a theoretical model for electrolyte-insulator-semiconductor capacitors (EISCAP) decorated with ligand-stabilized charged gold nanoparticles. The charged AuNPs are taken into account as additional, nanometer-sized local gates. The capacitance-voltage (C-V) curves and constant-capacitance (ConCap) signals of the AuNP-decorated EISCAPs have been simulated. The impact of the AuNP coverage on the shift of the C-V curves and the ConCap signals was also studied experimentally on Al-p-Si-SiO₂ EISCAPs decorated with positively charged aminooctanethiol-capped AuNPs. In addition, the surface of the EISCAPs, modified with AuNPs, was characterized by scanning electron microscopy for different immobilization times of the nanoparticles. Basel MDPI 2022 14 Seiten Biosensors 12 This article belongs to the Special Issue "Biosensors in Nanotechnology" 5 10.3390/bios12050334 weltweit https://doi.org/10.3390/bios12050334 INB - Institut für Nano- und Biotechnologien OPUS4-8972 Wissenschaftlicher Artikel Dantism, Shahriar, Dantism@fh-aachen.de; Röhlen, Desiree, roehlen@fh-aachen.de; Selmer, Thorsten, selmer@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Quantitative differential monitoring of the metabolic activity of Corynebacterium glutamicum cultures utilizing a light-addressable potentiometric sensor system Amsterdam Elsevier 2019 Biosensors and Bioelectronics 139 111332 10.1016/j.bios.2019.111332 bezahl https://doi.org/10.1016/j.bios.2019.111332 Fachbereich Medizintechnik und Technomathematik OPUS4-4851 Wissenschaftlicher Artikel Schusser, Sebastian, schusser@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Leinhos, Marcel, leinhos@fh-aachen.de; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de Characterization of biodegradable polymers with capacitive field-effect sensors In vitro studies of the degradation kinetic of biopolymers are essential for the design and optimization of implantable biomedical devices. In the presented work, a field-effect capacitive sensor has been applied for the real-time and in situ monitoring of degradation processes of biopolymers for the first time. The polymer-covered field-effect sensor is, in principle, capable to detect any changes in bulk, surface and interface properties of the polymer induced by degradation processes. The feasibility of this approach has been experimentally proven by using the commercially available biomedical polymer poly(D,L-lactic acid) (PDLLA) as a model system. PDLLA films of different thicknesses were deposited on the Ta₂O₅-gate surface of the field-effect structure from a polymer solution by means of spin-coating method. The polymer-modified field-effect sensors have been characterized by means of capacitance-voltage and impedance-spectroscopy method. The degradation of the PDLLA was accelerated by changing the degradation medium from neutral (pH 7.2) to alkaline (pH 9) condition, resulting in drastic changes in the capacitance and impedance spectra of the polymer-modified field-effect sensor. Amsterdam Elsevier 2012 5 Sensors and actuators B: Chemical 187 Part of special issue "Selected Papers from the 14th International Meeting on Chemical Sensors" 2 7 10.1016/j.snb.2012.07.099 campus https://doi.org/10.1016/j.snb.2012.07.099 Fachbereich Medizintechnik und Technomathematik