Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-4266 Wissenschaftlicher Artikel Doorschodt, B. M., ; Schreinemachers, M. C. J. M., ; Behbahani, Mehdi, behbahani@fh-aachen.de; Florquin, S., ; Weis, J., ; Staat, Manfred, m.staat@fh-aachen.de; Tolba, R. H., Hypothermic machine perfusion of kidney grafts: which pressure is preferred Berlin Springer 2011 8 Annals of Biomedical Engineering. 39 (2011), H. 3 1573-9686 1051 1059 campus http://dx.doi.org/10.1007/s10439-010-0228-7 Fachbereich Medizintechnik und Technomathematik OPUS4-4451 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Behr, M., ; Hormes, M., ; Steinseifer, U., ; Arora, D., ; Coronado, O., ; Pasquali, M., A Review of Computational Fluid Dynamics Analysis of Blood Pumps Cambridge Cambridge Univ. Press 2009 34 European Journal of Applied Mathematics. 20 (2009), H. 4 363 397 campus http:/dx.doi.org/10.1017/S0956792509007839 Fachbereich Medizintechnik und Technomathematik OPUS4-4452 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Finocchiaro, Thomas, ; Heinke, Stefanie, ; Leßmann, Marc, Methods of design, simulation, and control for the development of new VAD/TAH concepts = Methoden zur Konstruktion, Simulation und Regelung für die Entwicklung von neuen VAD/TAH-Konzepten / Finocchiaro, Thomas ; Heinke, Stefanie ; Behbahani, Mehdi ; Leßma 2009 12 Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5 0013-5585 Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471 269 281 campus http://dx.doi.org/10.1515/BMT.2009.031 Fachbereich Medizintechnik und Technomathematik OPUS4-4453 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Spillner, Jan, ; Kopp, Rüdiger, ; Finocchiaro, Thomas, Assistierte Zirkulation : ein Überblick aus klinischer Sicht = Assisted circulation: an overview from a clinical perspective / Spillner, Jan ; Kopp, Rüdiger ; Finocchiaro, Thomas ; Behbahani, Mehdi ; Rossaint, Rolf ; Steinseifer, Ulrich ; Behr, Marek ; Au Berlin De Gruyter 2009 12 Biomedizinische Technik / Biomedical Engineering. 54 (2009), H. 5 0013-5585 Printausgabe in der Bereichsbibliothek Jülich vorhanden : 63 Z 471 255 267 campus http://dx.doi.org/10.1515/BMT.2009.037 Fachbereich Medizintechnik und Technomathematik OPUS4-4454 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Behr, Marek, ; Nicolai, Mike, ; Probst, Markus, Towards Shape Optimization for Ventricular Assist Devices Using Parallel Stabilized FEM Jülich Forschungszentrum 2008 IV, 358 S. : Ill., graph. Darst. NIC Symposium 2008 : symposium, 20 - 21 February 2008, Forschungszentrum Jülich ; proceedings / organized by John von Neumann Institute for Computing. Ed. by Gernot Münster; Dietrich Wolf; Manfred Kremer (ed.) 978-3-9810843-5-1 NIC series ; 39 325 332 Fachbereich Medizintechnik und Technomathematik OPUS4-4455 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Nicolai, M., ; Probst, M., ; Behr, M., Simulation of Blood Flow in a Ventricular Assist Device 2007 3 inSIDE. 5 (2007), H. 1 28 31 Fachbereich Medizintechnik und Technomathematik OPUS4-4456 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Behr, M., ; Bischof, F., ; Wolf, G. E., Kranken Herzen helfen - Ingenieure und Informatiker entwickeln gemeinsam eine Miniaturblutpumpe / Behbahani, M. ; Behr, M. ; Bischof, F. ; Wolf, G. E. 2007 2 RWTH-Themen (2007) 0179-079X 44 46 weltweit http://www.rwth-aachen.de/global/show_document.asp?id=aaaaaaaaaaaszfj Fachbereich Medizintechnik und Technomathematik OPUS4-4457 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Nicolai, M., Interaktive Exploration von Blutströmungsprozessen in Herzpumpen Aachen Virtual Reality Center 2006 2 VRCA-Jahresbericht 2005/2006 Virtual Reality Center 88 90 weltweit http://www.vrca.rwth-aachen.de/jabe/2006/pdf/VRCA-Jahresbericht_2006.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-4458 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Behr, M., ; Arora, D., ; Coronado, O., ; Pasquali, M., CFD Analysis of MicroMed Debakey Pump and Hemolysis Prediction / Behbahani, M. ; Behr, M. ; Arora, D. ; Coronado, O. ; Pasquali, M. 2006 NaN Artificial Organs. 30 (2006), H. 11 1525-1594 Abstracts 14th Congress of the International Society for Rotary Blood Pumps, Leuven, Belgium, August 31-September 2, 2006 ; S7-4 A45 A46 bezahl http://dx.doi.org/10.1111/j.1525-1594.2006.00320.x Fachbereich Medizintechnik und Technomathematik OPUS4-4459 Wissenschaftlicher Artikel Steinseifer, Ulrich, ; Kashefi, Ali, ; Hormes, Marcus, ; Schoberer, Mark, ; Orlikowsky, Thorsten, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Behr, Marek, ; Schmitz-Rode, Thomas, Miniaturization of ECMO Systems : Engineering Challenges and Methods 2009 NaN Artificial Organs. 33 (2009), H. 5 1525-1594 Fifth International Conference on Pediatric Mechanical Circulatory Support Systems and Pediatric Cardiopulmonary Perfusion Abstracts A55 A55 campus http://dx.doi.org/10.1111/j.1525-1594.2009.00834.x Fachbereich Medizintechnik und Technomathematik OPUS4-4460 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Probst, M., ; Mai, A., ; Tran, L., ; Vonderstein, K., ; Keschenau, P., ; Linde, T., ; Steinseifer, U., ; Behr, M., ; Mottaghy, K., The influence of high shear on thrombosis and hemolysis in artificial organs 2010 0 Artificial Organs 33 0391-3988 Special Issue: SI ; Meeting abstract 7 426 426 Fachbereich Medizintechnik und Technomathematik OPUS4-4461 Wissenschaftlicher Artikel Jansen, Sebastian, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Laumen, Marco, ; Kaufmann, Tim, ; Hormes, Marcus, ; Schmitz-Rode, Thomas, ; Behr, Marek, ; Steinseifer, Ulrich, 3D Stereo-PIV Validation for CFD-Simulation of Steady Flow through the Human Aorta using Rapid-Prototyping techniques 2010 abstract ; IV International Symposium on Modelling of Physiological Flows, Sardinia, Italy, June 02-05, 2010 ; MPF2010 Fachbereich Medizintechnik und Technomathematik OPUS4-4497 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Mai, A., ; Bergmann, B., ; Waluga, C., ; Behr, M., ; Tran, L., ; Vonderstein, K., ; Mottaghy, K., Modeling and Numerical Simulation of Blood Damage 2010 Posterpresentation ; Umbrella Symposium "Modelling and Simulation in Medicine, Engineering and Sciences", Forschungszentrum Jülich, January 18-20, 2010 weltweit http://www.cats.rwth-aachen.de:8080/~mb/poster-umbrella-2010.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-4498 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Waluga, C., ; Arlt, S., ; Behr, M., ; Mottaghy, K., Computational Analysis of Platelet Aggregation in a Taylor-Couette System 2008 The International Journal of Artificial Organs. 31 (2008), H. 7 0391-3988 Posterpresentation ; European Society of Artificial Organs (ESAO), Geneva, Switzerland 643 Fachbereich Medizintechnik und Technomathematik OPUS4-4499 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Mai, A., ; Waluga, C., ; Bergmann, B., ; Tran, L., ; Vonderstein, K., ; Behr, M., ; Mottaghy, K., Numerical Modeling of Flow-Related Thrombus Formation under Physiological and Non-Physiological Flow Conditions 2010 Acta Physiologica 198 1748-1716 Joint Congress of the Scandinavian and German Physiological Societies, Copenhagen, Denmark, March 27-30, 2010 Supplement 677 185 Fachbereich Medizintechnik und Technomathematik OPUS4-4486 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Tran, L., ; Jockenhövel, S., ; Behr, M., ; Mottaghy, K., Numerical prediction of thrombocyte reactions for application to a vascular flow model Oxford Oxford University Press 2011 British Journal of Surgery 98 1365-2168 46th Congress of the European Society for Surgical Research, Aachen, Germany, 25-28 May 2011 ; ESSR Abstracts 2011 ; Oral Sessions OP10-5 S5 S17 campus http://dx.doi.org/10.1002/bjs.7577 Fachbereich Medizintechnik und Technomathematik OPUS4-4488 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Tran, L., ; Waluga, C., ; Behr, M., ; Oedekoven, B., ; Mottaghy, K., Model-based Numerical Analysis of Platelet Adhesion, Thrombus Growth and Aggregation for Assist Devices 2009 0 The International Journal of Artificial Organs. 32 (2009), H. 7 0391-3988 Abstracts - Oral Presentations: XXXVI Annual ESAO Congress, 2-5 September 2009, Compiègne - France; European Society of Artificial Organs (ESAO), Compiegne, France, September 2-5, 2009 398 398 weltweit http://www.artificial-organs.com/public/IJAO/Article/Attach.action?cmd=Download&uid=EE62A17A-291D-4D9A-A7A1-58E4754776B8 Fachbereich Medizintechnik und Technomathematik OPUS4-4491 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Nam, J., ; Waluga, C., ; Behr, M., ; Pasquali, M., ; Mottaghy, K., Modeling and Numerical Analysis of Platelet Activation, Adhesion and Aggregation in Artificial Organs 2010 Posterpresentation American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 10.1097/01.mat.0000369377.65122.a3 weltweit http://dx.doi.org/10.1097/01.mat.0000369377.65122.a3 Fachbereich Medizintechnik und Technomathematik OPUS4-4492 Wissenschaftlicher Artikel Jansen, S. V., ; Behbahani, Mehdi, behbahani@fh-aachen.de; Laumen, M., ; Kaufmann, T., ; Hormes, M., ; Behr, M., ; Schmitz-Rode, T., ; Steinseifer, U., Investigation of Steady Flow Through a Realistic Model of the Thoracic Human Aorta Using 3D Stereo PIV and CFD-Simulation 2010 Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 weltweit http://www.cats.rwth-aachen.de:8080/~mb/poster2-asaio-2010.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-4493 Wissenschaftlicher Artikel Nam, J., ; Arora, D., ; Behbahani, Mehdi, behbahani@fh-aachen.de; Probst, M., ; Benkowski, R., ; Behr, M., ; Pasquali, M., New computational method in hemolysis analysis for artificial heart pump 2010 Posterpresentation ; American Society of Artificial Organs (ASAIO), Baltimore, USA, May 27-29, 2010 weltweit http://www.cats.rwth-aachen.de:8080/~mb/poster3-asaio-2010.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-4494 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Probst, M., ; Mai, A., ; Behr, M., ; Tran, L., ; Vonderstein, K., ; Mottaghy, K., Numerical Prediction of Blood Damage in Biomedical Devices 2010 Posterpresentation ; Biomedica Congress, Aachen, March 17-18, 2010 weltweit http://www.cats.rwth-aachen.de:8080/~mb/poster-biomedica-2010.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-4495 Wissenschaftlicher Artikel Probst, M., ; Behbahani, Mehdi, behbahani@fh-aachen.de; Borrmann, E., ; Elgeti, S., ; Nicolai, M., ; Behr, M., Hemodynamic Modeling for Numerical Analysis and Design of Medical Devices 2010 Posterpresentation ; NIC Symposium 2010 ; 24 - 25 February 2010 Jülich, Germany weltweit http://www.cats.rwth-aachen.de:8080/~mb/poster-nic-2010.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-4496 Wissenschaftlicher Artikel Behbahani, Mehdi, behbahani@fh-aachen.de; Waluga, C., ; Stock, S., ; Mai, A., ; Bergmann, B., ; Behr, M., ; Tran, L., ; Vonderstein, K., ; Scheidt, H., ; Oedekoven, B., ; Mottaghy, K., Modelling and Numerical Analysis of Platelet Reactions and Surface Thrombus Growth 2009 Posterpresentation ; European Society of Biomaterials (ESB), Lausanne, Switzerland, September 7-10, 2009 Fachbereich Medizintechnik und Technomathematik OPUS4-6125 Wissenschaftlicher Artikel Jiminez German, Salvador, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Miettinen, Susanna, ; Grijpma, Dirk W., ; Haimi, Suvi P., Proliferation and differentiation of adipose stem cells towards smooth muscle cells on poly(trimethylene carbonate) membranes Weinheim Wiley 2013 9 Macromolecular symposia Vol. 334 Iss. 1 133 142 campus http://dx.doi.org/10.1002/masy.201300100 Fachbereich Medizintechnik und Technomathematik OPUS4-7732 Wissenschaftlicher Artikel Pookhalil, Ali, ; Amoabediny, Ghassem, ; Tabesh, Hadi, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Mottaghy, Khosrow, A new approach for semiempirical modeling of mechanical blood trauma Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis. London Sage 2016 6 The international journal of artificial organs 39 4 171 177 10.5301/ijao.5000474 bezahl https://doi.org/10.5301/ijao.5000474 Fachbereich Medizintechnik und Technomathematik OPUS4-8149 Wissenschaftlicher Artikel Tran, Linda, ; Mottaghy, K., ; Arlt-Körfer, Sabine, ; Waluga, Christian, ; Behbahani, Mehdi, behbahani@fh-aachen.de An experimental study of shear-dependent human platelet adhesion and underlying protein-binding mechanisms in a cylindrical Couette system Berlin De Gruyter 2017 9 Biomedizinische Technik 62 4 383 392 10.1515/bmt-2015-0034 Fachbereich Medizintechnik und Technomathematik OPUS4-10892 Wissenschaftlicher Artikel Thiebes, Anja Lena, ; Klein, Sarah, ; Zingsheim, Jonas, ; Möller, Georg H., ; Gürzing, Stefanie, ; Reddemann, Manuel A., ; Behbahani, Mehdi, behbahani@fh-aachen.de; Cornelissen, Christian G., Effervescent atomizer as novel cell spray technology to decrease the gas-to-liquid ratio Cell spraying has become a feasible application method for cell therapy and tissue engineering approaches. Different devices have been used with varying success. Often, twin-fluid atomizers are used, which require a high gas velocity for optimal aerosolization characteristics. To decrease the amount and velocity of required air, a custom-made atomizer was designed based on the effervescent principle. Different designs were evaluated regarding spray characteristics and their influence on human adipose-derived mesenchymal stromal cells. The arithmetic mean diameters of the droplets were 15.4-33.5 µm with decreasing diameters for increasing gas-to-liquid ratios. The survival rate was >90% of the control for the lowest gas-to-liquid ratio. For higher ratios, cell survival decreased to approximately 50%. Further experiments were performed with the design, which had shown the highest survival rates. After seven days, no significant differences in metabolic activity were observed. The apoptosis rates were not influenced by aerosolization, while high gas-to-liquid ratios caused increased necrosis levels. Tri-lineage differentiation potential into adipocytes, chondrocytes, and osteoblasts was not negatively influenced by aerosolization. Thus, the effervescent aerosolization principle was proven suitable for cell applications requiring reduced amounts of supplied air. This is the first time an effervescent atomizer was used for cell processing. Basel MDPI 2022 Artikel 2421 pharmaceutics 14 This article belongs to the Special Issue "Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells" 11 10.3390/pharmaceutics14112421 weltweit https://doi.org/10.3390/pharmaceutics14112421 Fachbereich Medizintechnik und Technomathematik OPUS4-9069 Dissertation Behbahani, Mehdi, behbahani@fh-aachen.de Modeling and Simulation of Shear-Dependent Platelet Reactions in Blood Vessels and Blood-Contacting Medical Devices München Verlag Dr. Hut 2011 978-3-8439-0134-5 Zugl.: Rheinisch-Westfälische Technische Hochschule Aachen, Diss., 2011 weltweit http://d-nb.info/1017353697 Fachbereich Medizintechnik und Technomathematik OPUS4-9386 Wissenschaftlicher Artikel Kopp, Alexander, ; Schunck, Laura, ; Gosau, Martin, ; Smeets, Ralf, ; Burg, Simon, ; Fuest, Sandra, ; Kröger, Nadja, ; Zinser, Max, ; Krohn, Sebastian, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Köpf, Marius, ; Lauts, Lisa, ; Rutkowski, Rico, Influence of the casting concentration on the mechanical and optical properties of Fa/CaCl2-derived silk fibroin membranes In this study, we describe the manufacturing and characterization of silk fibroin membranes derived from the silkworm Bombyx mori. To date, the dissolution process used in this study has only been researched to a limited extent, although it entails various potential advantages, such as reduced expenses and the absence of toxic chemicals in comparison to other conventional techniques. Therefore, the aim of this study was to determine the influence of different fibroin concentrations on the process output and resulting membrane properties. Casted membranes were thus characterized with regard to their mechanical, structural and optical assets via tensile testing, SEM, light microscopy and spectrophotometry. Cytotoxicity was evaluated using BrdU, XTT, and LDH assays, followed by live-dead staining. The formic acid (FA) dissolution method was proven to be suitable for the manufacturing of transparent and mechanically stable membranes. The fibroin concentration affects both thickness and transparency of the membranes. The membranes did not exhibit any signs of cytotoxicity. When compared to other current scientific and technical benchmarks, the manufactured membranes displayed promising potential for various biomedical applications. Further research is nevertheless necessary to improve reproducible manufacturing, including a more uniform thickness, less impurity and physiological pH within the membranes. Basel MDPI 2020 International Journal of Molecular Sciences 21 Special issue: Optimization of Biomaterials for Reconstructive and Regenerative Medicine 18 art. no. 6704 10.3390/ijms21186704 weltweit https://doi.org/10.3390/ijms21186704 Fachbereich Medizintechnik und Technomathematik OPUS4-9642 Wissenschaftlicher Artikel Brockhaus, Moritz K., ; Behbahani, Mehdi, behbahani@fh-aachen.de; Muris, Farina, ; Jansen, Sebastian V., ; Schmitz- Rode, Thomas, ; Steinseifer, Ulrich, ; Clauser, Johanna C., In vitro thrombogenicity testing of pulsatile mechanical circulatory support systems: Design and proof-of-concept Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. This study presents a novel in vitro method for reproducible thrombogenicity testing of pulsatile MCS systems using low molecular weight heparinized porcine blood. Blood parameters are continuously measured with full blood thromboelastometry (ROTEM; EXTEM, FIBTEM and a custom-made analysis HEPNATEM). Thrombus formation is optically observed after four hours of testing. The results of three experiments are presented each with two parallel loops. The area of thrombus formation inside the MCS device was reproducible. The implantation of a filter inside the loop catches embolizing thrombi without a measurable increase of platelet activation, allowing conclusions of the place of origin of thrombi inside the device. EXTEM and FIBTEM parameters such as clotting velocity (α) and maximum clot firmness (MCF) show a total decrease by around 6% with a characteristic kink after 180 minutes. HEPNATEM α and MCF rise within the first 180 minutes indicate a continuously increasing activation level of coagulation. After 180 minutes, the consumption of clotting factors prevails, resulting in a decrease of α and MCF. With the designed mock loop and the presented protocol we are able to identify thrombogenic hot spots inside a pulsatile pump and characterize their thrombogenic potential. Weinheim Wiley 2021 8 Artificial Organs 45 12 1513 1521 10.1111/aor.14046 weltweit https://doi.org/10.1111/aor.14046 Fachbereich Medizintechnik und Technomathematik OPUS4-10068 Wissenschaftlicher Artikel Malinowski, Daniel, ; Fournier, Yvan, ; Horbach, Andreas, horbach@fh-aachen.de; Frick, Michael, ; Magliani, Mirko, ; Kalverkamp, Sebastian, ; Hildinger, Martin, ; Spillner, Jan, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Hima, Flutura, Computational fluid dynamics analysis of endoluminal aortic perfusion Introduction: In peripheral percutaneous (VA) extracorporeal membrane oxygenation (ECMO) procedures the femoral arteries perfusion route has inherent disadvantages regarding poor upper body perfusion due to watershed. With the advent of new long flexible cannulas an advancement of the tip up to the ascending aorta has become feasible. To investigate the impact of such long endoluminal cannulas on upper body perfusion, a Computational Fluid Dynamics (CFD) study was performed considering different support levels and three cannula positions. Methods: An idealized literature-based- and a real patient proximal aortic geometry including an endoluminal cannula were constructed. The blood flow was considered continuous. Oxygen saturation was set to 80% for the blood coming from the heart and to 100% for the blood leaving the cannula. 50% and 90% venoarterial support levels from the total blood flow rate of 6 l/min were investigated for three different positions of the cannula in the aortic arch. Results: For both geometries, the placement of the cannula in the ascending aorta led to a superior oxygenation of all aortic blood vessels except for the left coronary artery. Cannula placements at the aortic arch and descending aorta could support supra-aortic arteries, but not the coronary arteries. All positions were able to support all branches with saturated blood at 90% flow volume. Conclusions: In accordance with clinical observations CFD analysis reveals, that retrograde advancement of a long endoluminal cannula can considerably improve the oxygenation of the upper body and lead to oxygen saturation distributions similar to those of a central cannulation. London Sage 2022 7 Perfusion 0 0 1 8 10.1177/02676591221099809 weltweit https://doi.org/10.1177/02676591221099809 Fachbereich Medizintechnik und Technomathematik OPUS4-10070 Wissenschaftlicher Artikel Lenz, Maximilian, ; Kahmann, Stephanie Lucina, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Pennig, Lenhard, ; Hackl, Michael, ; Leschinger, Tim, ; Müller, Lars Peter, ; Wegmann, Kilian, Influence of rotator cuff preload on fracture configuration in proximal humerus fractures: a proof of concept for fracture simulation Introduction In regard of surgical training, the reproducible simulation of life-like proximal humerus fractures in human cadaveric specimens is desirable. The aim of the present study was to develop a technique that allows simulation of realistic proximal humerus fractures and to analyse the influence of rotator cuff preload on the generated lesions in regards of fracture configuration. Materials and methods Ten cadaveric specimens (6 left, 4 right) were fractured using a custom-made drop-test bench, in two groups. Five specimens were fractured without rotator cuff preload, while the other five were fractured with the tendons of the rotator cuff preloaded with 2 kg each. The humeral shaft and the shortened scapula were potted. The humerus was positioned at 90° of abduction and 10° of internal rotation to simulate a fall on the elevated arm. In two specimens of each group, the emergence of the fractures was documented with high-speed video imaging. Pre-fracture radiographs were taken to evaluate the deltoid-tuberosity index as a measure of bone density. Post-fracture X-rays and CT scans were performed to define the exact fracture configurations. Neer's classification was used to analyse the fractures. Results In all ten cadaveric specimens life-like proximal humerus fractures were achieved. Two III-part and three IV-part fractures resulted in each group. The preloading of the rotator cuff muscles had no further influence on the fracture configuration. High-speed videos of the fracture simulation revealed identical fracture mechanisms for both groups. We observed a two-step fracture mechanism, with initial impaction of the head segment against the glenoid followed by fracturing of the head and the tuberosities and then with further impaction of the shaft against the acromion, which lead to separation of the tuberosities. Conclusion A high energetic axial impulse can reliably induce realistic proximal humerus fractures in cadaveric specimens. The preload of the rotator cuff muscles had no influence on initial fracture configuration. Therefore, fracture simulation in the proximal humerus is less elaborate. Using the presented technique, pre-fractured specimens are available for real-life surgical education. Berlin, Heidelberg Springer 2022 Archives of Orthopaedic and Trauma Surgery 10.1007/s00402-022-04471-9 weltweit https://doi.org/10.1007/s00402-022-04471-9 Fachbereich Medizintechnik und Technomathematik OPUS4-10071 Wissenschaftlicher Artikel Chloé, Radermacher, ; Malyaran, Hanna, ; Craveiro, Rogerio Bastos, ; Peglow, Sarah, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Pufe, Thomas, ; Wolf, Michael, ; Neuss, Sabine, Mechanical loading on cementoblasts: a mini review Orthodontic treatments are concomitant with mechanical forces and thereby cause teeth movements. The applied forces are transmitted to the tooth root and the periodontal ligaments which is compressed on one side and tensed up on the other side. Indeed, strong forces can lead to tooth root resorption and the crown-to-tooth ratio is reduced with the potential for significant clinical impact. The cementum, which covers the tooth root, is a thin mineralized tissue of the periodontium that connects the periodontal ligament with the tooth and is build up by cementoblasts. The impact of tension and compression on these cells is investigated in several in vivo and in vitro studies demonstrating differences in protein expression and signaling pathways. In summary, osteogenic marker changes indicate that cyclic tensile forces support whereas static tension inhibits cementogenesis. Furthermore, cementogenesis experiences the same protein expression changes in static conditions as static tension, but cyclic compression leads to the exact opposite of cyclic tension. Consistent with marker expression changes, the singaling pathways of Wnt/ß-catenin and RANKL/OPG show that tissue compression leads to cementum degradation and tension forces to cementogenesis. However, the cementum, and in particular its cementoblasts, remain a research area which should be explored in more detail to understand the underlying mechanism of bone resorption and remodeling after orthodontic treatments. Stuttgart Thieme 2022 7 Osteologie 31 2 111 118 10.1055/a-1826-0777 bezahl https://doi.org/10.1055/a-1826-0777 Fachbereich Medizintechnik und Technomathematik OPUS4-8944 Wissenschaftlicher Artikel Kopp, Alexander, ; Schmeets, Ralf, ; Gosau, Martin, ; Friedrich, Reinhard E., ; Fuest, Sandra, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Barbeck, Mike, ; Rutkowski, Rico, ; Burg, Simon, ; Kluwe, Lan, ; Henningsen, Anders, Production and Characterization of Porous Fibroin Scaffolds for Regenerative Medical Application 2019 5 In Vivo 33 3 757 762 10.21873/invivo.11536 weltweit https://doi.org/10.21873/invivo.11536 Fachbereich Medizintechnik und Technomathematik OPUS4-9707 Konferenzveröffentlichung Mandekar, Swati, swati.mandekar@alumni.fhaachen.de; Jentsch, Lina, ; Lutz, Kai, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Melnykowycz, Mark, Earable design analysis for sleep EEG measurements Conventional EEG devices cannot be used in everyday life and hence, past decade research has been focused on Ear-EEG for mobile, at-home monitoring for various applications ranging from emotion detection to sleep monitoring. As the area available for electrode contact in the ear is limited, the electrode size and location play a vital role for an Ear-EEG system. In this investigation, we present a quantitative study of ear-electrodes with two electrode sizes at different locations in a wet and dry configuration. Electrode impedance scales inversely with size and ranges from 450 kΩ to 1.29 MΩ for dry and from 22 kΩ to 42 kΩ for wet contact at 10 Hz. For any size, the location in the ear canal with the lowest impedance is ELE (Left Ear Superior), presumably due to increased contact pressure caused by the outer-ear anatomy. The results can be used to optimize signal pickup and SNR for specific applications. We demonstrate this by recording sleep spindles during sleep onset with high quality (5.27 μVrms). 2021 4 UbiComp '21 UbiComp '21: Adjunct Proceedings of the 2021 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2021 ACM International Symposium on Wearable Computers, September 21-26, 2021, Virtual, USA 171 175 10.1145/3460418.3479328 campus https://doi.org/10.1145/3460418.3479328 Fachbereich Medizintechnik und Technomathematik OPUS4-8663 Konferenzveröffentlichung Behbahani, Mehdi, behbahani@fh-aachen.de An Experimental Study of Thrombocyte Reactions in Response to Biomaterial Surfaces and Varying Shear Stress 2014 Proceedings of the International Conference on Biomedical Engineering and Systems Prague, Czech Republic, August 14-15, 2014 Paper 125 weltweit https://avestia.com/ICBES2014_Proceedings/papers/125.pdf IfB - Institut für Bioengineering OPUS4-8664 Konferenzveröffentlichung Behbahani, Mehdi, behbahani@fh-aachen.de; Rible, Sebastian, ; Moulinec, Charles, ; Fournier, Yvan, ; Nicolai, Mike, ; Crosetto, Paolo, Simulation of the FDA Centrifugal Blood Pump Using High Performance Computing 2015 World Academy of Science, Engineering and Technology International Journal of Mechanical and Mechatronics Engineering 9 5 weltweit http://waset.org/pdf/books/?id=27635 Fachbereich Medizintechnik und Technomathematik OPUS4-8665 Konferenzveröffentlichung Marinova, V., ; Kerroumi, I., ; Lintermann, A., ; Göbbert, J.H., ; Moulinec, C., ; Rible, S., ; Fournier, Y., ; Behbahani, Mehdi, behbahani@fh-aachen.de Numerical Analysis of the FDA Centrifugal Blood Pump 2016 9 NIC Symposium 2016 978-3-95806-109-5 355 364 http://hdl.handle.net/2128/9842 Fachbereich Medizintechnik und Technomathematik OPUS4-9896 Wissenschaftlicher Artikel Mandekar, Swati, ; Holland, Abigail, ; Thielen, Moritz, ; Behbahani, Mehdi, behbahani@fh-aachen.de; Melnykowycz, Mark, Advancing towards Ubiquitous EEG, Correlation of In-Ear EEG with Forehead EEG Wearable EEG has gained popularity in recent years driven by promising uses outside of clinics and research. The ubiquitous application of continuous EEG requires unobtrusive form-factors that are easily acceptable by the end-users. In this progression, wearable EEG systems have been moving from full scalp to forehead and recently to the ear. The aim of this study is to demonstrate that emerging ear-EEG provides similar impedance and signal properties as established forehead EEG. EEG data using eyes-open and closed alpha paradigm were acquired from ten healthy subjects using generic earpieces fitted with three custom-made electrodes and a forehead electrode (at Fpx) after impedance analysis. Inter-subject variability in in-ear electrode impedance ranged from 20 kΩ to 25 kΩ at 10 Hz. Signal quality was comparable with an SNR of 6 for in-ear and 8 for forehead electrodes. Alpha attenuation was significant during the eyes-open condition in all in-ear electrodes, and it followed the structure of power spectral density plots of forehead electrodes, with the Pearson correlation coefficient of 0.92 between in-ear locations ELE (Left Ear Superior) and ERE (Right Ear Superior) and forehead locations, Fp1 and Fp2, respectively. The results indicate that in-ear EEG is an unobtrusive alternative in terms of impedance, signal properties and information content to established forehead EEG. Basel MDPI 2022 18 Sensors 22 4 1 19 10.3390/s22041568 weltweit https://doi.org/10.3390/s22041568 Fachbereich Medizintechnik und Technomathematik OPUS4-11006 Konferenzveröffentlichung Schmitz, Annika, ; Apandi, Shah Eiman Amzar Shah, ; Spillner, Jan, ; Hima, Flutura, ; Behbahani, Mehdi, behbahani@fh-aachen.de Digel, Ilya; Staat, Manfred; Trzewik, Jürgen; Sielemann, Stefanie; Erni, Daniel; Zylka, Waldemar Effect of different cannula positions in the pulmonary artery on blood flow and gas exchange using computational fluid dynamics analysis Pulmonary arterial cannulation is a common and effective method for percutaneous mechanical circulatory support for concurrent right heart and respiratory failure [1]. However, limited data exists to what effect the positioning of the cannula has on the oxygen perfusion throughout the pulmonary artery (PA). This study aims to evaluate, using computational fluid dynamics (CFD), the effect of different cannula positions in the PA with respect to the oxygenation of the different branching vessels in order for an optimal cannula position to be determined. The four chosen different positions (see Fig. 1) of the cannulas are, in the lower part of the main pulmonary artery (MPA), in the MPA at the junction between the right pulmonary artery (RPA) and the left pulmonary artery (LPA), in the RPA at the first branch of the RPA and in the LPA at the first branch of the LPA. Duisburg Universität Duisburg-Essen 2024 1 4th YRA MedTech Symposium 2024 : February 1 / 2024 / FH Aachen 978-3-940402-65-3 29 30 10.17185/duepublico/81475 weltweit https://doi.org/10.17185/duepublico/81475 Fachbereich Medizintechnik und Technomathematik