Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-5151 Wissenschaftlicher Artikel Kotliar, Konstantin, kotliar@fh-aachen.de; Hanssen, Henner, ; Eberhardt, Karla, ; Vilser, Walthard, ; Schmaderer, Christoph, ; Halle, Martin, ; Heemann, Uwe, ; Baumann, M., Retinal pulse wave velocity in young male normotensive and mildly hypertensive subjects Malden Wiley 2013 Microcirculation Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.) campus http://dx.doi.org/10.1111/micc.12036 Fachbereich Medizintechnik und Technomathematik OPUS4-4814 Wissenschaftlicher Artikel Kotliar, Konstantin, kotliar@fh-aachen.de; Mücke, Bruno, ; Vilser, Walthard, ; Schilling, Rudolf, Effect of aging on retinal artery blood column diameter measured along the vessel axis / Kotliar, Konstantin E. ; Mücke, Bruno ; Vilser, Walthard ; Schilling, Rudolf ; Lanzl, Ines M. - 2008 8 Investigative Ophthalmology & Visual Science, IOVS. 49 (2008), H. 5 0146-0404 2094 2102 weltweit http://dx.doi.org/10.1167/iovs.07-0711 Fachbereich Medizintechnik und Technomathematik OPUS4-4832 Wissenschaftlicher Artikel Kotliar, Konstantin, kotliar@fh-aachen.de; Baumann, Marcus, ; Vilser, Walthard, ; Lanzl, Ines M., Pulse wave velocity in retinal arteries of healthy volunteers London BMJ Publ. Group 2011 4 British Journal of Ophthalmology (eBJO) 95 1468-2079 11 675 679 campus http://dx.doi.org/10.1136/bjo.2010.181263 Fachbereich Medizintechnik und Technomathematik OPUS4-4837 Wissenschaftlicher Artikel Garhofer, Gerhard, ; Bek, Toke, ; Boehm, Andreas G., ; Gherghel, Doina, ; Grundwald, Juan, ; Jeppesen, Peter, ; Kergoat, Hélène, ; Kotliar, Konstantin, kotliar@fh-aachen.de; Lanzl, Ines, ; Lovasik, John V., ; Nagel, Edgar, ; Vilser, Walthard, ; Orgul, Selim, ; Schmetterer, Leopold, Use of the retinal vessel analyzer in ocular blood flow research 2010 5 Acta Ophthalmol 88 1600-0420 7 717 722 campus http://dx.doi.org/10.1111/j.1755-3768.2009.01587.x Fachbereich Medizintechnik und Technomathematik OPUS4-4844 Wissenschaftlicher Artikel Kotliar, Konstantin, kotliar@fh-aachen.de; Lanzl, Ines M., ; Witta, Birka, ; Vilser, Walthard, Reaktion retinaler Gefäßdurchmesser auf 100 % O2-Atmung - funktionelle Messung mit dem Retinal Vessel Analyzer an 10 Probanden / Lanzl, Ines M. ; Witta, Birke ; Kotliar, Konstantin ; Vilser, Walthard - 2000 4 Klinische Monatsblätter für Augenheilkunde. 217 (2000), H. 4 1439-3999 = Retinal vessel reaction to 100 % O2 breathing - functional imaging by retinal vessel analyzer in 10 volunteers 231 235 campus http://dx.doi.org/10.1055/s-2000-10354 Fachbereich Medizintechnik und Technomathematik OPUS4-4816 Wissenschaftlicher Artikel Kotliar, Konstantin, kotliar@fh-aachen.de; Nagel, Edgar, ; Vilser, Walthard, ; Seidova, Seid-Fatima, ; Lanzl, Ines, Microstructural alterations of retinal arterial blood column along the vessel axis in systemic hypertension - 2010 7 Investigative Ophthalmology & Visual Science, IOVS 51 0146-0404 4 2165 2172 weltweit http://dx.doi.org/10.1167/iovs.09-3649 Fachbereich Medizintechnik und Technomathematik OPUS4-4820 Wissenschaftlicher Artikel Kotliar, Konstantin, kotliar@fh-aachen.de; Nagel, Edgar, ; Vilser, Walthard, ; Lanzl, Ines M., Functional in vivo assessment of retinal artery microirregularities in glaucoma / Kotliar, Konstantin E. ; Nagel, Edgar ; Vilser, Walthard ; Lanzl, Ines M. - 2008 9 Acta Ophthalmologica. 86 (2008), H. 4 1755-3768 424 433 campus http://dx.doi.org/10.1111/j.1600-0420.2007.01072.x Fachbereich Medizintechnik und Technomathematik OPUS4-9423 Wissenschaftlicher Artikel Conzen, Catharina, ; Albanna, Walid, ; Weiss, Miriam, ; Kürten, David, ; Vilser, Walthard, ; Kotliar, Konstantin, kotliar@fh-aachen.de; Zäske, Charlotte, ; Clusmann, Hans, ; Schubert, Gerrit Alexander, Vasoconstriction and Impairment of Neurovascular Coupling after Subarachnoid Hemorrhage: a Descriptive Analysis of Retinal Changes Impaired cerebral autoregulation and neurovascular coupling (NVC) contribute to delayed cerebral ischemia after subarachnoid hemorrhage (SAH). Retinal vessel analysis (RVA) allows non-invasive assessment of vessel dimension and NVC hereby demonstrating a predictive value in the context of various neurovascular diseases. Using RVA as a translational approach, we aimed to assess the retinal vessels in patients with SAH. RVA was performed prospectively in 24 patients with acute SAH (group A: day 5-14), in 11 patients 3 months after ictus (group B: day 90 ± 35), and in 35 age-matched healthy controls (group C). Data was acquired using a Retinal Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and NVC using flicker-light excitation. Diameter of retinal vessels—central retinal arteriolar and venular equivalent—was significantly reduced in the acute phase (p < 0.001) with gradual improvement in group B (p < 0.05). Arterial NVC of group A was significantly impaired with diminished dilatation (p < 0.001) and reduced area under the curve (p < 0.01) when compared to group C. Group B showed persistent prolonged latency of arterial dilation (p < 0.05). Venous NVC was significantly delayed after SAH compared to group C (A p < 0.001; B p < 0.05). To our knowledge, this is the first clinical study to document retinal vasoconstriction and impairment of NVC in patients with SAH. Using non-invasive RVA as a translational approach, characteristic patterns of compromise were detected for the arterial and venous compartment of the neurovascular unit in a time-dependent fashion. Recruitment will continue to facilitate a correlation analysis with clinical course and outcome. Cham Springer Nature 2018 9 Translational Stroke Research 9 284 293 10.1007/s12975-017-0585-8 campus https://doi.org/10.1007/s12975-017-0585-8 Fachbereich Medizintechnik und Technomathematik OPUS4-9405 Wissenschaftlicher Artikel Malan, Leone, ; Hamer, Mark, ; Känel, Roland von, ; Kotliar, Konstantin, kotliar@fh-aachen.de; Wyk, Roelof D. van, ; Lambert, Gavin W., ; Vilser, Walthard, ; Ziemssen, Tjalf, ; Schlaich, Markus P., ; Smith, Wayne, ; Magnusson, Martin, ; Wentzel, Annemarie, ; Myburgh, Carlien E., ; Steyn, Hendrik S., ; Malan, Nico T., Delayed retinal vein recovery responses indicate both non-adaptation to stress as well as increased risk for stroke: the SABPA study Durbanville Clinics Cardive Publishing 2020 11 Cardiovascular Journal of Africa 26 31 1 12 10.5830/CVJA-2020-031 weltweit https://doi.org/10.5830/CVJA-2020-031 Fachbereich Medizintechnik und Technomathematik OPUS4-8609 Wissenschaftlicher Artikel Albanna, Walid, ; Kotliar, Konstantin, kotliar@fh-aachen.de; Lüke, Jan Niklas, ; Alpdogan, Serdar, ; Conzen, Catharina, ; Lindauer, Ute, ; Clusmann, Hans, ; Hescheler, Jürgen, ; Vilser, Walthard, ; Schneider, Toni, ; Schubert, Gerrit Alexander, Non-invasive evaluation of neurovascular coupling in the murine retina by dynamic retinal vessel analysis Background Impairment of neurovascular coupling (NVC) was recently reported in the context of subarachnoid hemorrhage and may correlate with disease severity and outcome. However, previous techniques to evaluate NVC required invasive procedures. Retinal vessels may represent an alternative option for non-invasive assessment of NVC. Methods A prototype of an adapted retinal vessel analyzer was used to assess retinal vessel diameter in mice. Dynamic vessel analysis (DVA) included an application of monochromatic flicker light impulses in predefined frequencies for evaluating NVC. All retinae were harvested after DVA and electroretinograms were performed. Results A total of 104 retinal scans were conducted in 21 male mice (90 scans). Quantitative arterial recordings were feasible only in a minority of animals, showing an emphasized reaction to flicker light impulses (8 mice; 14 scans). A characteristic venous response to flicker light, however, could observed in the majority of animals. Repeated measurements resulted in a significant decrease of baseline venous diameter (7 mice; 7 scans, p < 0.05). Ex-vivo electroretinograms, performed after in-vivo DVA, demonstrated a significant reduction of transretinal signaling in animals with repeated DVA (n = 6, p < 0.001). Conclusions To the best of our knowledge, this is the first non-invasive study assessing murine retinal vessel response to flicker light with characteristic changes in NVC. The imaging system can be used for basic research and enables the investigation of retinal vessel dimension and function in control mice and genetically modified animals. San Francisco PLOS 2018 14 Seiten Plos one 10.1371/journal.pone.0204689 weltweit https://doi.org/10.1371/journal.pone.0204689 Fachbereich Medizintechnik und Technomathematik OPUS4-9226 Wissenschaftlicher Artikel Smith, Wayne, ; Kotliar, Konstantin, kotliar@fh-aachen.de; Lammertyn, Leandi, ; Ramoshaba, Nthai E., ; Vilser, Walthard, ; Huisman, Hugo W., ; Schutte, Aletta E., Retinal vessel caliber and caliber responses in true normotensive black and white adults: The African-PREDICT study Purpose Globally, a detrimental shift in cardiovascular disease risk factors and a higher mortality level are reported in some black populations. The retinal microvasculature provides early insight into the pathogenesis of systemic vascular diseases, but it is unclear whether retinal vessel calibers and acute retinal vessel functional responses differ between young healthy black and white adults. Methods We included 112 black and 143 white healthy normotensive adults (20-30 years). Retinal vessel calibers (central retinal artery and vein equivalent (CRAE and CRVE)) were calculated from retinal images and vessel caliber responses to flicker light induced provocation (FLIP) were determined. Additionally, ambulatory blood pressure (BP), anthropometry and blood samples were collected. Results The groups displayed similar 24 h BP profiles and anthropometry (all p > .24). Black participants demonstrated a smaller CRAE (158 ± 11 vs. 164 ± 11 MU, p < .001) compared to the white group, whereas CRVE was similar (p = .57). In response to FLIP, artery maximal dilation was greater in the black vs. white group (5.6 ± 2.1 vs. 3.3 ± 1.8%; p < .001). Conclusions Already at a young age, healthy black adults showed narrower retinal arteries relative to the white population. Follow-up studies are underway to show if this will be related to increased risk for hypertension development. The reason for the larger vessel dilation responses to FLIP in the black population is unclear and warrants further investigation. Amsterdam Elsevier 2020 Microvascular Research 128 Article 103937 10.1016/j.mvr.2019.103937 bezahl https://doi.org/10.1016/j.mvr.2019.103937 Fachbereich Luft- und Raumfahrttechnik OPUS4-4815 Wissenschaftlicher Artikel Kotliar, Konstantin, kotliar@fh-aachen.de; Lanzl, Ines M., ; Hanssen, Henner, ; Eberhardt, Karla, ; Vilser, Walthard, ; Halle, Martin, ; Heemann, Uwe, ; Schmidt-Trucksäss, Arno, ; Baumann, Marcus, Does increased blood pressure rather than aging influence retinal pulse wave velocity? Purpose: It was demonstrated previously that retinal pulse wave velocity (rPWV) as a measure of retinal arterial stiffness is increased in aged anamnestically healthy volunteers compared with young healthy subjects. Using novel methodology of rPWV assessment this finding was confirmed and investigated whether it might relate to the increased blood pressure usually accompanying the aging process, rather than to the aging itself. Methods: A total of 12 young 25.5-year-old (24.0-28.8) [median(1st quartile-3rd quartile)] and 12 senior 68.5-year-old (63.8-71.8) anamnestically healthy volunteers; and 12 senior 63.0-year-old (60.8-65.0) validated healthy volunteers and 12 young 33.0-year-old (29.5-35.0) hypertensive patients were examined. Time-dependent alterations of vessel diameter were assessed by the Dynamic Vessel Analyzer in a retinal artery of each subject. The data were filtered and processed using mathematical signal analysis and rPWVs were calculated. Results: rPWV amounted to 1200 (990-1470) RU (relative units)/s in the hypertensive group and to 1040 (700-2230) RU/s in anamnestically healthy seniors. These differed significantly from rPWVs in young healthy group (410 [280-500] RU/s) and in validated healthy seniors (400 [320-510] RU/s). rPWV associated with age and mean arterial pressure (MAP) in the pooled cohort excluded validated healthy seniors. In a regression model these associations remain when alternately adjusted for MAP and age. When including validated healthy seniors in the pooled cohort only association with MAP remains. Conclusions: Both aging (with not excluded cardiovascular risk factors) and mild hypertension are associated with elevated rPWV. rPWV increases to a similar extent both in young mildly hypertensive subjects and in aged anamnestically healthy persons. Healthy aging is not associated with increased rPWV. Rockville, Md. ARVO 2012 7 Investigative Ophthalmology & Visual Science, IOVS 53 4 2119 2126 10.1167/iovs.11-8815 weltweit https://doi.org/10.1167/iovs.11-8815 Fachbereich Medizintechnik und Technomathematik