Dokument-ID Dokumenttyp Verfasser/Autoren Herausgeber Haupttitel Abstract Auflage Verlagsort Verlag Erscheinungsjahr Seitenzahl Schriftenreihe Titel Schriftenreihe Bandzahl ISBN Quelle der Hochschulschrift Konferenzname Bemerkung Quelle:Titel Quelle:Jahrgang Quelle:Heftnummer Quelle:Erste Seite Quelle:Letzte Seite URN DOI Zugriffsart Link Abteilungen OPUS4-8976 Wissenschaftlicher Artikel Özsoylu, Dua, ; Kizildag, Sefa, dua.oezsoylu@alumni.fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Effect of plasma treatment on the sensor properties of a light-addressable potentiometric sensor (LAPS) A light-addressable potentiometric sensor (LAPS) is a field-effect-based (bio-) chemical sensor, in which a desired sensing area on the sensor surface can be defined by illumination. Light addressability can be used to visualize the concentration and spatial distribution of the target molecules, e.g., H+ ions. This unique feature has great potential for the label-free imaging of the metabolic activity of living organisms. The cultivation of those organisms needs specially tailored surface properties of the sensor. O2 plasma treatment is an attractive and promising tool for rapid surface engineering. However, the potential impacts of the technique are carefully investigated for the sensors that suffer from plasma-induced damage. Herein, a LAPS with a Ta2O5 pH-sensitive surface is successfully patterned by plasma treatment, and its effects are investigated by contact angle and scanning LAPS measurements. The plasma duration of 30 s (30 W) is found to be the threshold value, where excessive wettability begins. Furthermore, this treatment approach causes moderate plasma-induced damage, which can be reduced by thermal annealing (10 min at 300 °C). These findings provide a useful guideline to support future studies, where the LAPS surface is desired to be more hydrophilic by O2 plasma treatment. Weinheim Wiley 2019 8 Seiten physica status solidi a : applications and materials sciences 216 Corresponding author: Torsten Wagner 20 10.1002/pssa.201900259 weltweit https://doi.org/10.1002/pssa.201900259 Fachbereich Medizintechnik und Technomathematik OPUS4-9332 Wissenschaftlicher Artikel Özsoylu, Dua, oezsoylu@fh-aachen.de; Kizildag, Sefa, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Differential chemical imaging of extracellular acidification within microfluidic channels using a plasma-functionalized light-addressable potentiometric sensor (LAPS) Extracellular acidification is a basic indicator for alterations in two vital metabolic pathways: glycolysis and cellular respiration. Measuring these alterations by monitoring extracellular acidification using cell-based biosensors such as LAPS plays an important role in studying these pathways whose disorders are associated with numerous diseases including cancer. However, the surface of the biosensors must be specially tailored to ensure high cell compatibility so that cells can represent more in vivo-like behavior, which is critical to gain more realistic in vitro results from the analyses, e.g., drug discovery experiments. In this work, O2 plasma patterning on the LAPS surface is studied to enhance surface features of the sensor chip, e.g., wettability and biofunctionality. The surface treated with O2 plasma for 30 s exhibits enhanced cytocompatibility for adherent CHO-K1 cells, which promotes cell spreading and proliferation. The plasma-modified LAPS chip is then integrated into a microfluidic system, which provides two identical channels to facilitate differential measurements of the extracellular acidification of CHO-K1 cells. To the best of our knowledge, it is the first time that extracellular acidification within microfluidic channels is quantitatively visualized as differential (bio-)chemical images. Amsterdam Elsevier 2020 8 Physics in Medicine 10 100030 10.1016/j.phmed.2020.100030 weltweit https://doi.org/10.1016/j.phmed.2020.100030 Fachbereich Medizintechnik und Technomathematik OPUS4-2931 Wissenschaftlicher Artikel Zatko, B., ; Dubecký, F., ; Bohacek, P., ; Gombia, E., ; Frigeri, P., ; Mosca, R., ; Franchi, S., ; Huarn, J., ; Nescas, V., ; Sekacova, M., ; Förster, Arnold, foerster@fh-aachen.de; Kordos, P., On the spectrometric performance limit of radiation detectors based on semi-insulating GaAs 2004 9 Nuclear instruments and methods in physics research, Section A. 531 (2004), H. 1-2 0168-9002 111 120 campus http://dx.doi.org/10.1016/j.nima.2004.05.102 Fachbereich Energietechnik OPUS4-9413 Buch (Monographie) Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de Yoshinobu, Tatsuo; Schöning, Michael Josef Light-addressing and chemical imaging technologies for electrochemical sensing Basel MDPI 2020 122 Pages 978-3-03943-029-1 This book is a printed edition of the Special Issue Light-Addressing and Chemical Imaging Technologies for Electrochemical Sensing that was published in Sensors 10.3390/books978-3-03943-029-1 weltweit https://doi.org/10.3390/books978-3-03943-029-1 Fachbereich Medizintechnik und Technomathematik OPUS4-9536 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors (LAPS) for cell monitoring and biosensing Amsterdam Elsevier 2021 Current Opinion in Electrochemistry In Press, Journal Pre-proof 10.1016/j.coelec.2021.100727 bezahl https://doi.org/10.1016/j.coelec.2021.100727 Fachbereich Medizintechnik und Technomathematik OPUS4-7288 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Moritz, Werner, ; Finger, Friedhelm, ; Schöning, Michael Josef, schoening@fh-aachen.de Comini, Elisabetta Application of thin-film amorphous silicon to chemical imaging 2006 9 Nanostructured materials and hybrid composites for gas sensors and biomedical applications : symposium held April 18-20, 2006, San Francisco , California, U.S.A. 9781558998711 Materials Research Society symposia proceedings; v. 915 Paper 0910-A-20-01 1 10 Fachbereich Medizintechnik und Technomathematik OPUS4-8064 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-ichiro, ; Werner, Frederik, f.werner@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors for quantitative spatial imaging of chemical species 2017 21 Annual Review of Analytical Chemistry 10 225 246 10.1146/annurev-anchem-061516-045158 Fachbereich Medizintechnik und Technomathematik OPUS4-4682 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-Ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Miniaturized and high-speed chemical imaging systems - 2012 9 Nano-Boomedical Engineering 2012 :Proceedings of the Tohoku University Global Centre of Excellence Programme / Sakura Hall, Tohoku University, Sendai Japan, 5 – 6 March 2012 / ed. by Takami Yamaguchi 386 395 bezahl http://dx.doi.org/10.1142/9781848169067_0045 Fachbereich Medizintechnik und Technomathematik OPUS4-6666 Wissenschaftlicher Artikel Yoshinobu, Tatsuo, ; Miyamoto, Ko-ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor Amsterdam Elsevier 2015 6 Sensors and actuators B: Chemical 207 Part B 926 932 campus https://dx.doi.org/10.1016/j.snb.2014.09.002 Fachbereich Medizintechnik und Technomathematik OPUS4-8606 Teil eines Buches Yoshinobu, Tatsuo, ; Krause, Steffi, ; Miyamoto, Ko-ichiro, ; Werner, Frederik, f.werner@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de (Bio-)chemical Sensing and Imaging by LAPS and SPIM The light-addressable potentiometric sensor (LAPS) and scanning photo-induced impedance microscopy (SPIM) are two closely related methods to visualise the distributions of chemical species and impedance, respectively, at the interface between the sensing surface and the sample solution. They both have the same field-effect structure based on a semiconductor, which allows spatially resolved and label-free measurement of chemical species and impedance in the form of a photocurrent signal generated by a scanning light beam. In this article, the principles and various operation modes of LAPS and SPIM, functionalisation of the sensing surface for measuring various species, LAPS-based chemical imaging and high-resolution sensors based on silicon-on-sapphire substrates are described and discussed, focusing on their technical details and prospective applications. Cham Springer 2018 29 Label-free biosensing: advanced materials, devices and applications 978-3-319-75219-8 103 132 campus https://doi.org/10.1007/5346_2017_22 Fachbereich Medizintechnik und Technomathematik OPUS4-1965 Wissenschaftlicher Artikel Yoshinobu, T., ; Yasuhito, U., ; Iwasaki, H., ; Näther, Niko, naether@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Koudelka-Hep, M., Applications of the light-addressable potentiometric sensor to microfluidic devices Roma 2004 790 S.: Ill., graph. Darst. 1 CD-ROM Digest of technical papers : September 12 - 15, 2004, Rome, Italy, Pontificia Universitas Sancto Thoma Aquinate in Urbe / [conference chairperson: C. Di Natale]. 88-7621-282-5 Eurosensors ; (18, 2004, Roma) 434 437 Fachbereich Medizintechnik und Technomathematik OPUS4-1755 Wissenschaftlicher Artikel Yoshinobu, T., ; Ui, Y., ; Iwasaki, H., ; Näther, Niko, naether@fh-aachen.de; Koudelka-Hep, M., ; Schöning, Michael Josef, schoening@fh-aachen.de Potentiometric imaging in a microfluidic channel 2004 1 Biomedizinische Technik. 49 (2004), H. 2 0932-4666 998 999 Fachbereich Medizintechnik und Technomathematik OPUS4-1979 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Furuichi, K., ; Mourzina, Yu, ; Ermelenko, Yu, ; Iwasaki, I., Portable light-addressable potentiometric sensor (LAPS) for multisensor applications Prague Czech Technical University, Faculty of Electrical Engineering, Department of Measurement 2002 3 Book of abstracts / ed. by J. Saneistr. 80-01-02576-4 Eurosensors ; (16, 2002, Praha) 898 901 Fachbereich Medizintechnik und Technomathematik OPUS4-1768 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Furuichi, K., ; Mourzina, Y., ; Ermelenko, Y., ; Iwasaki, H., Portable light-addressable potentiometric sensor (LAPS) for multisensor applications 2003 4 Sensors and Actuators B. 95 (2003), H. 1-3 0925-4005 352 356 campus http://dx.doi.org/10.1016/S0925-4005(03)00437-4 Fachbereich Medizintechnik und Technomathematik OPUS4-1751 Wissenschaftlicher Artikel Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Finger, F., ; Moritz, W., ; Iwasaki, H., Fabrication of thin-film LAPS with amorphous silicon 2004 6 Sensors. 4 (2004), H. 10 1424-8220 163 169 weltweit http://www.mdpi.org/sensors/papers/s41000163.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-6854 Konferenzveröffentlichung Yoshinobu, T., ; Schöning, Michael Josef, schoening@fh-aachen.de; Finger, F., ; Moritz, W., ; Iwasaki, H., Thin-film a-Si LAPS : Preparation and pH sensitivity 2003 1 Eurosensors XVII : the 17th European Conference on Solid-State Transducers ; University of Minho, Guimarães, Portugal, September 21 - 24, 2003 Eurosensors <17, 2003, Guimarães> 88 89 weltweit http://repositorium.sdum.uminho.pt/bitstream/1822/4837/1/BookOfAbstractsFinal.pdf Fachbereich Medizintechnik und Technomathematik OPUS4-1954 Wissenschaftlicher Artikel Yoshinobu, T., ; Iwasaki, H., ; Ui, Y., ; Furuichi, K., ; Ermelenko, Y., ; Mourzina, Y., ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Näther, Niko, naether@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de The light-addressable potentiometric sensor for multi-ion sensing and imaging 2005 3 Methods. 37 (2005), H. 1 1046-2023 99 102 campus http://dx.doi.org/10.1016/j.ymeth.2005.05.020 Fachbereich Medizintechnik und Technomathematik OPUS4-1974 Wissenschaftlicher Artikel Yoshinobu, T., ; Ermelenko, Y., ; Mourzina, Y., ; Schöning, Michael Josef, schoening@fh-aachen.de; Iwasaki, H., ; Vlasov, Y., Multi-component analysis based on the light-addressable potentiometric sensor (LAPS) Wunstorf AMA Service 2003 3 Proceedings : 11th international conference Sensor 2003; 13 - 15 May 2003, Exhibition Centre Nuremberg, Germany Internationale Messe mit Kongress Sensor <11, 2003, Nürnberg> 141 144 Fachbereich Medizintechnik und Technomathematik OPUS4-1874 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Simonis, A., ; Iwasaki, H., ; Lüth, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Constant-current-mode LAPS (CLAPS) for the detection of penicillin 2001 3 Electroanalysis. 13 (2001), H. 8-9 1040-0397 733 736 campus http://www3.interscience.wiley.com/cgi-bin/abstract/82502248/ABSTRACT Fachbereich Medizintechnik und Technomathematik OPUS4-1812 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Poghossian, Arshak, poghossian@fh-aachen.de; Lüth, H., ; Iwasaki, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Alternative sensor materials for light-addressable potentiometric sensors 2001 4 Sensors and Actuators B. 76 (2001), H. 1-3 0925-4005 388 392 campus http://dx.doi.org/10.1016/S0925-4005(01)00646-3 Fachbereich Medizintechnik und Technomathematik OPUS4-1688 Wissenschaftlicher Artikel Yoshinobu, T., ; Ecken, H., ; Ismail, Md.A.B., ; Iwasaki, H., ; Lüth, H., ; Schöning, Michael Josef, schoening@fh-aachen.de Chemical imaging sensor and its application to biological systems Amsterdam [u.a.] Elsevier [u.a.] 2001 385 S. : Ill., graph. Darst. Scaling down in electrochemistry : electrochemical micro- and nanosystem technology ; proceedings of the 3rd International Symposium on Electrochemical Microsystem Technologies, Garmisch-Patenkirchen, Germany, 11 - 15 September 2000 / ed. by J. W. Schultz 0-08-044014-2 259 263 Fachbereich Medizintechnik und Technomathematik OPUS4-6113 Konferenzveröffentlichung Wu, Chunsheng, c.wu@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Wang, Ping, ; Schöning, Michael Josef, schoening@fh-aachen.de An application of a scanning light-addressable potentiometric sensor for label-free DNA detection 2013 4 11. Dresdner Sensor-Symposium : 9.-11.12.2013 978-3-9813484-5-3 164 168 weltweit http://dx.doi.org/10.5162/11dss2013/A9 Fachbereich Medizintechnik und Technomathematik OPUS4-7692 Wissenschaftlicher Artikel Wu, Chunsheng, C.Wu@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor A multi-spot light-addressable potentiometric sensor (LAPS), which belongs to the family of semiconductor field-effect devices, was applied for label-free detection of double-stranded deoxyribonucleic acid (dsDNA) molecules by their intrinsic molecular charge. To reduce the distance between the DNA charge and sensor surface and thus, to enhance the electrostatic coupling between the dsDNA molecules and the LAPS, the negatively charged dsDNA molecules were electrostatically adsorbed onto the gate surface of the LAPS covered with a positively charged weak polyelectrolyte layer of PAH (poly(allylamine hydrochloride)). The surface potential changes in each spot of the LAPS, induced by the layer-by-layer adsorption of a PAH/dsDNA bilayer, were recorded by means of photocurrent-voltage and constant-photocurrent measurements. In addition, the surface morphology of the gate surface before and after consecutive electrostatic adsorption of PAH and dsDNA layers was studied by atomic force microscopy measurements. Moreover, fluorescence microscopy was used to verify the successful adsorption of dsDNA molecules onto the PAH-modified LAPS surface. A high sensor signal of 25 mV was registered after adsorption of 10 nM dsDNA molecules. The lower detection limit is down to 0.1 nM dsDNA. The obtained results demonstrate that the PAH-modified LAPS device provides a convenient and rapid platform for the direct label-free electrical detection of in-solution hybridized dsDNA molecules. Amsterdam Elsevier 2016 6 Sensors and Actuators B: Chemical 229 506 512 10.1016/j.snb.2016.02.004 bezahl https://doi.org/10.1016/j.snb.2016.02.004 Fachbereich Medizintechnik und Technomathematik OPUS4-7046 Wissenschaftlicher Artikel Wu, Chunsheng, C.Wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Label-free detection of DNA using light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer 2015 7 Nanoscale 7 6143 6150 10.1039/C4NR07225A Fachbereich Medizintechnik und Technomathematik OPUS4-6444 Wissenschaftlicher Artikel Wu, Chunsheng, c.wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Bäcker, Matthias, baecker@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Label-free electrical detection of DNA with a multi-spot LAPS: First step towards light-addressable DNA chips A multi-spot (4 × 4 spots) light-addressable potentiometric sensor (MLAPS) consisting of an Al-p-Si-SiO2 structure has been applied for the label-free electrical detection of DNA (deoxyribonucleic acid) immobilization and hybridization by the intrinsic molecular charge for the first time. Single-stranded probe ssDNA molecules (20 bases) were covalently immobilized onto the silanized SiO2 gate surface. The unspecific adsorption of mismatch ssDNA on the MLAPS gate surface was blocked by bovine serum albumin molecules. To reduce the screening effect and to achieve a high sensor signal, the measurements were performed in a low ionic-strength solution. The photocurrent-voltage (I-V) curves were simultaneously recorded on all 16 spots after each surface functionalization step. Large shifts of I-V curves of 25 mV were registered after the DNA immobilization and hybridization event. In contrast, a small potential shift (∼5 mV) was observed in case of mismatch ssDNA, revealing good specificity of the sensor. The obtained results demonstrate the potential of the MLAPS as promising transducer platform for the multi-spot label-free electrical detection of DNA molecules by their intrinsic molecular charge. Weinheim Wiley-VCH 2014 5 Physica status solidi A : Applications and materials science 211 6 1423 1428 10.1002/pssa.201330442 campus https://doi.org/10.1002/pssa.201330442 Fachbereich Medizintechnik und Technomathematik OPUS4-6725 Konferenzveröffentlichung Wu, Chunsheng, c.wu@fh-aachen.de; Bronder, Thomas, bronder@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de DNA-hybridization detection using light-addressable potentiometric sensor modified with gold layer Düsseldorf VDE-Verl. 2014 1 CD-ROM Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250) 978-3-8007-3622-5 1 4 Fachbereich Medizintechnik und Technomathematik OPUS4-5985 Wissenschaftlicher Artikel Wilming, Anja, ; Begemann, Jens, ; Kuhne, Stefan, ; Regestein, Lars, ; Bongaerts, Johannes, bongaerts@fh-aachen.de; Evers, Stefan, ; Maurer, Karl-Heinz, ; Büchs, Jochen, Metabolic studies of γ-polyglutamic acid production in Bacillus licheniformis by small-scale continuous cultivations Amsterdam Elsevier 2013 8 Biochemical engineering journal Vol. 73 29 37 campus http://dx.doi.org/10.1016/j.bej.2013.01.008 Fachbereich Chemie und Biotechnologie OPUS4-5988 Wissenschaftlicher Artikel Wiegand, Sandra, ; Dietrich, Sascha, ; Hertel, Robert, ; Bongaerts, Johannes, bongaerts@fh-aachen.de; Evers, Stefan, ; Volland, Sonja, ; Daniel, Rolf, ; Liesegang, Heiko, RNA-Seq of Bacillus licheniformis: active regulatory RNA features expressed within a productive fermentation London BioMed Central 2013 BMC genomics Vol. 14 667 weltweit http://dx.doi.org/10.1186/1471-2164-14-667 Fachbereich Chemie und Biotechnologie OPUS4-6499 Wissenschaftlicher Artikel Whitehead, Mark, ; Öhlschläger, Peter, oehlschlaeger@fh-aachen.de; Almajhdi, Fahad N., ; Alloza, Leonor, ; Marzábal, Pablo, ; Meyers, Ann E., ; Hitzeroth, Inga I., ; Rybicki, Edward P., Human papillomavirus (HPV) type 16 E7 protein bodies cause tumour regression in mice London BioMed Central 2014 14 BMC cancer 14:367 1 15 10.1186/1471-2407-14-367 weltweit https://doi.org/10.1186/1471-2407-14-367 Fachbereich Chemie und Biotechnologie OPUS4-9548 Wissenschaftlicher Artikel Wert, Stefan, ; Iken, Heiko, iken@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Matysik, Frank-Michael, Development of a temperature-pulse enhanced electrochemical glucose biosensor and characterization of its stability via scanning electrochemical microscopy Glucose oxidase (GOx) is an enzyme frequently used in glucose biosensors. As increased temperatures can enhance the performance of electrochemical sensors, we investigated the impact of temperature pulses on GOx that was drop-coated on flattened Pt microwires. The wires were heated by an alternating current. The sensitivity towards glucose and the temperature stability of GOx was investigated by amperometry. An up to 22-fold increase of sensitivity was observed. Spatially resolved enzyme activity changes were investigated via scanning electrochemical microscopy. The application of short (<100 ms) heat pulses was associated with less thermal inactivation of the immobilized GOx than long-term heating. Weinheim Wiley-VCH 2021 Electroanalysis Early View 10.1002/elan.202100089 weltweit https://doi.org/10.1002/elan.202100089 Fachbereich Medizintechnik und Technomathematik OPUS4-6724 Konferenzveröffentlichung Werner, Frederik, f.werner@fh-aachen.de; Yoshinobu, T., ; Miyamoto, K., ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Semiconductor-based sensors for imaging of chemical processes Düsseldorf VDE-Verl. 2014 1 CD-ROM Sensoren und Messsysteme 2014 ; Beiträge der 17. GMA/ITG-Fachtagung vom 3. bis 4. Juni 2014 in Nürnberg. (ITG-Fachbericht ; 250) 978-3-8007-3622-5 1 5 Fachbereich Medizintechnik und Technomathematik OPUS4-5315 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Frequency behaviour of light-addressable potentiometric sensors Weinheim Wiley-VCH 2013 7 Physica Status Solidi (A). Vol. 210 (2013), iss. 5 884 891 campus http://onlinelibrary.wiley.com/doi/10.1002/pssa.201200929/pdf Fachbereich Medizintechnik und Technomathematik OPUS4-2079 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up Light-addressable potentiometric sensors (LAPS) are field-effect-based sensors. A modulated light source is used to define the particular measurement spot to perform spatially resolved measurements of chemical species and to generate chemical images. In this work, an organic-LED (OLED) display has been chosen as a light source. This allows high measurement resolution and miniaturisation of the system. A new developed driving method for the OLED display optimised for LAPS-based measurements is demonstrated. The new method enables to define modulation frequencies between 1 kHz and 16 kHz and hence, reduces the measurement time of a chemical image by a factor of 40 compared to the traditional addressing of an OLED display. Amsterdam Elsevier 2012 4 Sensors and Actuators B: Chemical 175 Part of special issue "Selected Papers presented at Eurosensors XXV" 118 122 10.1016/j.snb.2011.12.102 campus https://doi.org/10.1016/j.snb.2011.12.102 Fachbereich Medizintechnik und Technomathematik OPUS4-4616 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up Amsterdam Elsevier 2011 3 Procedia Engineering. 25 (2011) 1877-7058 EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece 346 349 campus http://dx.doi.org/10.1016/j.proeng.2011.12.085 Fachbereich Medizintechnik und Technomathematik OPUS4-4960 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Takenaga, Shoko, ; Taki, Hidenori, ; Sawada, Kazuaki, ; Schöning, Michael Josef, schoening@fh-aachen.de Comparison of label-free ACh-imaging sensors based on CCD and LAPS Amsterdam Elsevier 2013 7 Sensors and Actuators B: Chemical (2012) 177 0925-4005 745 752 campus http://dx.doi.org/10.1016/j.snb.2012.11.012 Fachbereich Medizintechnik und Technomathematik OPUS4-4382 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Spelthahn, H., ; Schöning, Michael Josef, schoening@fh-aachen.de; Krumbe, C., ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, T., ; Keusgen, M., Neue Ansteuerungselektronik für LAPS-basierte Biosensoren zur gleichzeitig ortsaufgelösten Messung der pH-Konzentration Berlin VDE Verlag 2010 1 CD-ROM Sensoren und Messsysteme 2010 [Elektronische Ressource] : Vorträge der 15. ITG/GMA-Fachtagung vom 18. bis 19. Mai 2010 in Nürnberg / Informationstechnische Gesellschaft im VDE (ITG); VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik (GMA) 978-3-8007-3260-9 Fachtagung Sensoren und Messsysteme 15, 2010, Nürnberg ; Gesellschaft Mess- und Automatisierungstechnik 109 114 Fachbereich Medizintechnik und Technomathematik OPUS4-4273 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Schusser, Sebastian, schusser@fh-aachen.de; Spalthahn, Heiko, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de Field-programmable gate array based controller for multi spot light-addressable potentiometric sensors with integrated signal correction mode Amsterdam Elsevier 2011 4 Electrochimica Acta. 56 (2011), H. 26 0013-4686 9656 9660 campus http://dx.doi.org/10.1016/j.electacta.2011.03.012 Fachbereich Medizintechnik und Technomathematik OPUS4-8147 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor Amsterdam Elsevier 2017 4 Sensor and Actuators B: Chemical 248 961 965 10.1016/j.snb.2017.02.057 Fachbereich Medizintechnik und Technomathematik OPUS4-4363 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Krumbe, Christoph, ; Schumacher, Katharina, ; Groebel, Simone, groebel@fh-aachen.de; Spelthahn, Heiko, spelthahn@fh-aachen.de; Stellberg, Michael, stellberg@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Selmer, Thorsten, selmer@fh-aachen.de; Keusgen, Michael, ; Baumann, Marcus, rektor@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Determination of the extracellular acidification of Escherichia coli by a light-addressable potentiometric sensor Weinheim Wiley 2011 4 Physica status solidi (a) : applications and material science. 208 (2011), H. 6 1862-6319 1340 1344 campus http://dx.doi.org/10.1002/pssa.201001141 Fachbereich Chemie und Biotechnologie OPUS4-4391 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Groebel, Simone, groebel@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, Tatsuo, ; Selmer, Thorsten, selmer@fh-aachen.de; Baumann, Marcus, rektor@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Überwachung der metabolischen Aktivität von Mikroorganismen zur Kontrolle des biologischen Prozesses im Biogasfermenter Düsseldorf VDI-Verl. 2011 292 S. : Ill., graph. Darst., Kt. Biogas 2011 : Energieträger der Zukunft ; 6. Fachtagung, Fachtagung Braunschweig, 08. und 09. Juni 2011 / VDI Energie und Umwelt 978-3-18-092121-1 Gesellschaft Energie und Umwelt ; Fachtagung Biogas ; (6 : ; 2011.06.08-09 : ; Braunschweig) ; VDI-Berichte ; 2121 285 286 Fachbereich Chemie und Biotechnologie OPUS4-3982 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Groebel, Simone, groebel@fh-aachen.de; Schuhmacher, K., ; Spelthahn, Heiko, spelthahn@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Selmer, Thorsten, selmer@fh-aachen.de; Baumann, Marcus, rektor@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Bestimmung der metabolischen Aktivität von Mikroorganismen während des Biogasbildungsprozesses Dresden TUDpress 2009 351 S. : Ill., graph. Darst. 9. Dresdner Sensor-Symposium : Dresden, 07.-09. Dezember 2009 / Gerlach, Gerald ; Hauptmann, Peter [Hrsg.] 978-3-941298-44-6 Dresdner Sensor-Symposium ; (9, 2009, Dresden) 201 204 Fachbereich Chemie und Biotechnologie OPUS4-4752 Wissenschaftlicher Artikel Werner, Frederik, f.werner@fh-aachen.de; Groebel, Simone, groebel@fh-aachen.de; Krumbe, Christoph, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Selmer, Thorsten, selmer@fh-aachen.de; Yoshinobu, Tatsuo, ; Baumann, Marcus, rektor@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Nutrient concentration-sensitive microorganism-based biosensor - 2012 4 Physica Status Solidi / A 209 1862-6319 5 900 904 campus http://dx.doi.org/10.1002/pssa.201100801 Fachbereich Chemie und Biotechnologie OPUS4-6516 Dissertation Werner, Frederik, f.werner@fh-aachen.de Development of light-addressable potentiometric sensor systems and their applications in biotechnological environments 2014 XI, 149 S. Marburg, Univ., Diss., 2014 weltweit http://archiv.ub.uni-marburg.de/diss/z2014/0337/pdf/dcfw.pdf INB - Institut für Nano- und Biotechnologien OPUS4-10790 Wissenschaftlicher Artikel Wendlandt, Tim, ; Koch, Claudia, ; Britz, Beate, ; Liedek, Anke, ; Schmidt, Nora, ; Werner, Stefan, ; Gleba, Yuri, ; Vahidpour, Farnoosh, vahidpour@fh-aachen.de; Welden, Melanie, m.welden@fh-aachen.de; Poghossian, Arshak, ; Schöning, Michael Josef, schoening@fh-aachen.de Facile Purification and Use of Tobamoviral Nanocarriers for Antibody-Mediated Display of a Two-Enzyme System Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains D and E of Staphylococcus aureus protein A (PA) on every coat protein (CP) subunit (TVCVPA) were purified from plants via optimized and new protocols. The latter used polyethylene glycol (PEG) raw precipitates, from which virions were selectively re-solubilized in reverse PEG concentration gradients. This procedure improved the integrity of both TVCVPA and the wild-type subgroup 3 tobamovirus. TVCVPA could be loaded with more than 500 IgGs per virion, which mediated the immunocapture of fluorescent dyes, GFP, and active enzymes. Bi-enzyme ensembles of cooperating glucose oxidase and horseradish peroxidase were tethered together on the TVCVPA carriers via a single antibody type, with one enzyme conjugated chemically to its Fc region, and the other one bound as a target, yielding synthetic multi-enzyme complexes. In microtiter plates, the TVCVPA-displayed sugar-sensing system possessed a considerably increased reusability upon repeated testing, compared to the IgG-bound enzyme pair in the absence of the virus. A high coverage of the viral adapters was also achieved on Ta2O5 sensor chip surfaces coated with a polyelectrolyte interlayer, as a prerequisite for durable TVCVPA-assisted electrochemical biosensing via modularly IgG-assembled sensor enzymes. Basel MDPI 2023 Viruses 9 This article belongs to the Special Issue "Tobamoviruses 2023" 15 Artikel 1951 doi.org/10.3390/v15091951 weltweit https://doi.org/10.3390/v15091951 INB - Institut für Nano- und Biotechnologien OPUS4-9238 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick H., ; Wagner, Torsten, torsten.wagner@fh-aachen.de Light-Addressable Electrodes for Dynamic and Flexible Addressing of Biological Systems and Electrochemical Reactions In this review article, we are going to present an overview on possible applications of light-addressable electrodes (LAE) as actuator/manipulation devices besides classical electrode structures. For LAEs, the electrode material consists of a semiconductor. Illumination with a light source with the appropiate wavelength leads to the generation of electron-hole pairs which can be utilized for further photoelectrochemical reaction. Due to recent progress in light-projection technologies, highly dynamic and flexible illumination patterns can be generated, opening new possibilities for light-addressable electrodes. A short introduction on semiconductor-electrolyte interfaces with light stimulation is given together with electrode-design approaches. Towards applications, the stimulation of cells with different electrode materials and fabrication designs is explained, followed by analyte-manipulation strategies and spatially resolved photoelectrochemical deposition of different material types. Basel MDPI 2020 21 Sensors 20 Artikel-Nummer 1680 1 22 10.3390/s20061680 weltweit https://doi.org/10.3390/s20061680 Fachbereich Medizintechnik und Technomathematik OPUS4-8428 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Scheja, Sabrina, ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Patrick, ; Wagner, Torsten, torsten.wagner@fh-aachen.de Electrochemical Evaluation of Light-Addressable Electrodes Based on TiO2 for the Integration in Lab-on-Chip Systems In lab-on-chip systems, electrodes are important for the manipulation (e.g., cell stimulation, electrolysis) within such systems. An alternative to commonly used electrode structures can be a light-addressable electrode. Here, due to the photoelectric effect, the conducting area can be adjusted by modification of the illumination area which enables a flexible control of the electrode. In this work, titanium dioxide based light-addressable electrodes are fabricated by a sol-gel technique and a spin-coating process, to deposit a thin film on a fluorine-doped tin oxide glass. To characterize the fabricated electrodes, the thickness, and morphological structure are measured by a profilometer and a scanning electron microscope. For the electrochemical behavior, the dark current and the photocurrent are determined for various film thicknesses. For the spatial resolution behavior, the dependency of the photocurrent while changing the area of the illuminated area is studied. Furthermore, the addressing of single fluid compartments in a three-chamber system, which is added to the electrode, is demonstrated. Weinheim Wiley-VCH 2018 physica status solidi a : applications and materials sciences 215 15 Article number 1800150 10.1002/pssa.201800150 campus https://doi.org/10.1002/pssa.201800150 Fachbereich Medizintechnik und Technomathematik OPUS4-9958 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Nagamine Komesu, Cindy A., ; Wagner, Patrick H., ; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Photoelectrochemical enzymatic penicillin biosensor: A proof-of-concept experiment Photoelectrochemical (PEC) biosensors are a rather novel type of biosensors thatutilizelighttoprovideinformationaboutthecompositionofananalyte,enablinglight-controlled multi-analyte measurements. For enzymatic PEC biosensors,amperometric detection principles are already known in the literature. In con-trast, there is only a little information on H+-ion sensitive PEC biosensors. Inthis work, we demonstrate the detection of H+ions emerged by H+-generatingenzymes, exemplarily demonstrated with penicillinase as a model enzyme on atitanium dioxide photoanode. First, we describe the pH sensitivity of the sensorand study possible photoelectrocatalytic reactions with penicillin. Second, weshow the enzymatic PEC detection of penicillin. Weinheim Wiley-VCH 2021 4 Electrochemical Science Advances 2 Corresponding auhtor: Michael J. Schöning 4 1 5 10.1002/elsa.202100131 weltweit https://doi.org/10.1002/elsa.202100131 Fachbereich Medizintechnik und Technomathematik OPUS4-10521 Wissenschaftlicher Artikel Welden, Rene, welden@fh-aachen.de; Jablonski, Melanie, ; Wege, Christina, ; Keusgen, Michael, ; Wagner, Patrick Hermann, ; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Light-Addressable Actuator-Sensor Platform for Monitoring and Manipulation of pH Gradients in Microfluidics: A Case Study with the Enzyme Penicillinase The feasibility of light-addressed detection and manipulation of pH gradients inside an electrochemical microfluidic cell was studied. Local pH changes, induced by a light-addressable electrode (LAE), were detected using a light-addressable potentiometric sensor (LAPS) with different measurement modes representing an actuator-sensor system. Biosensor functionality was examined depending on locally induced pH gradients with the help of the model enzyme penicillinase, which had been immobilized in the microfluidic channel. The surface morphology of the LAE and enzyme-functionalized LAPS was studied by scanning electron microscopy. Furthermore, the penicillin sensitivity of the LAPS inside the microfluidic channel was determined with regard to the analyte's pH influence on the enzymatic reaction rate. In a final experiment, the LAE-controlled pH inhibition of the enzyme activity was monitored by the LAPS. Basel MDPI 2021 Artikel 171 Biosensors 11 This article belongs to the Special Issue "Selected Papers from the 1st International Electronic Conference on Biosensors (IECB 2020)" 6 10.3390/bios11060171 weltweit https://doi.org/10.3390/bios11060171 Fachbereich Chemie und Biotechnologie OPUS4-10516 Konferenzveröffentlichung Welden, Melanie, ; Severins, Robin, severins@fh-aachen.de; Poghossian, Arshak, ; Wege, Christina, ; Siegert, Petra, siegert@fh-aachen.de; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Studying the immobilization of acetoin reductase with Tobacco mosaic virus particles on capacitive field-effect sensors A capacitive electrolyte-insulator-semiconductor (EISCAP) biosensor modified with Tobacco mosaic virus (TMV) particles for the detection of acetoin is presented. The enzyme acetoin reductase (AR) was immobilized on the surface of the EISCAP using TMV particles as nanoscaffolds. The study focused on the optimization of the TMV-assisted AR immobilization on the Ta 2 O 5 -gate EISCAP surface. The TMV-assisted acetoin EISCAPs were electrochemically characterized by means of leakage-current, capacitance-voltage, and constant-capacitance measurements. The TMV-modified transducer surface was studied via scanning electron microscopy. IEEE 2022 4 Seiten 2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) 978-1-6654-5860-3 (Online) IEEE International Symposium on Olfaction and Electronic Nose (ISOEN), 29 May 2022 - 01 June 2022, Aveiro, Portugal. 10.1109/ISOEN54820.2022.9789657 campus https://doi.org/10.1109/ISOEN54820.2022.9789657 Fachbereich Medizintechnik und Technomathematik OPUS4-10515 Wissenschaftlicher Artikel Welden, Melanie, ; Severins, Robin, ; Poghossian, Arshak, ; Wege, Christina, ; Bongaerts, Johannes, bongaerts@fh-aachen.de; Siegert, Petra, siegert@fh-aachen.de; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Detection of acetoin and diacetyl by a tobacco mosaic virus-assisted field-effect biosensor Acetoin and diacetyl have a major impact on the flavor of alcoholic beverages such as wine or beer. Therefore, their measurement is important during the fermentation process. Until now, gas chromatographic techniques have typically been applied; however, these require expensive laboratory equipment and trained staff, and do not allow for online monitoring. In this work, a capacitive electrolyte-insulator-semiconductor sensor modified with tobacco mosaic virus (TMV) particles as enzyme nanocarriers for the detection of acetoin and diacetyl is presented. The enzyme acetoin reductase from Alkalihalobacillus clausii DSM 8716ᵀ is immobilized via biotin-streptavidin affinity, binding to the surface of the TMV particles. The TMV-assisted biosensor is electrochemically characterized by means of leakage-current, capacitance-voltage, and constant capacitance measurements. In this paper, the novel biosensor is studied regarding its sensitivity and long-term stability in buffer solution. Moreover, the TMV-assisted capacitive field-effect sensor is applied for the detection of diacetyl for the first time. The measurement of acetoin and diacetyl with the same sensor setup is demonstrated. Finally, the successive detection of acetoin and diacetyl in buffer and in diluted beer is studied by tuning the sensitivity of the biosensor using the pH value of the measurement solution. Basel MDPI 2022 Chemosensors 10 This article belongs to the Special Issue "Nanostructured Devices for Biochemical Sensing" 6 10.3390/chemosensors10060218 weltweit https://doi.org/10.3390/chemosensors10060218 Fachbereich Chemie und Biotechnologie OPUS4-10520 Wissenschaftlicher Artikel Welden, Melanie, ; Poghossian, Arshak, ; Vahidpour, Farnoosh, vahidpour@fh-aachen.de; Wendlandt, Tim, ; Keusgen, Michael, ; Wege, Christina, ; Schöning, Michael Josef, schoening@fh-aachen.de Towards multi-analyte detection with field-effect capacitors modified with tobacco mosaic virus bioparticles as enzyme nanocarriers Utilizing an appropriate enzyme immobilization strategy is crucial for designing enzyme-based biosensors. Plant virus-like particles represent ideal nanoscaffolds for an extremely dense and precise immobilization of enzymes, due to their regular shape, high surface-to-volume ratio and high density of surface binding sites. In the present work, tobacco mosaic virus (TMV) particles were applied for the co-immobilization of penicillinase and urease onto the gate surface of a field-effect electrolyte-insulator-semiconductor capacitor (EISCAP) with a p-Si-SiO₂-Ta₂O₅ layer structure for the sequential detection of penicillin and urea. The TMV-assisted bi-enzyme EISCAP biosensor exhibited a high urea and penicillin sensitivity of 54 and 85 mV/dec, respectively, in the concentration range of 0.1-3 mM. For comparison, the characteristics of single-enzyme EISCAP biosensors modified with TMV particles immobilized with either penicillinase or urease were also investigated. The surface morphology of the TMV-modified Ta₂O₅-gate was analyzed by scanning electron microscopy. Additionally, the bi-enzyme EISCAP was applied to mimic an XOR (Exclusive OR) enzyme logic gate. Basel MDPI 2022 Biosensors 12 This article belongs to the Special Issue "Biosensors: 10th Anniversary Feature Papers" 1 10.3390/bios12010043 weltweit https://doi.org/10.3390/bios12010043 Fachbereich Chemie und Biotechnologie OPUS4-6831 Konferenzveröffentlichung Weil, M., ; Poghossian, Arshak, poghossian@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Cherstvy, A., Electrical monitoring of layer-by-layer adsorption of oppositely charged macromolecules by means of capacitive field-effect devices 2012 3 978-3-9813484-2-2 14th International Meeting on Chemical Sensors - IMCS 2012 1575 1578 10.5162/IMCS2012/P2.5.2 weltweit Fachbereich Medizintechnik und Technomathematik OPUS4-7293 Wissenschaftlicher Artikel Warmer, Johannes, ; Wagner, Patrick, ; Schöning, Michael Josef, schoening@fh-aachen.de; Kaul, Peter, Detection of triacetone triperoxide using temperature cycled metal-oxide semiconductor gas sensors Weinheim Wiley-VCH 2015 9 Physica status solidi (a) 212 6 1289 1298 10.1002/pssa.201431882 campus https://doi.org/10.1002/pssa.201431882 Fachbereich Medizintechnik und Technomathematik OPUS4-1789 Wissenschaftlicher Artikel Wang, J., ; Krause, R., ; Block, K., ; Musameh, M., ; Mulchandani, A., ; Schöning, Michael Josef, schoening@fh-aachen.de Flow injection amperometric detection of OP nerve agents based on organophosphorus-hydrolase biosensor detector 2003 5 Biosensors & Bioelectronics. 18 (2003), H. 2-3 0956-5663 255 260 campus http://dx.doi.org/10.1016/S0956-5663(02)00178-1 Fachbereich Medizintechnik und Technomathematik OPUS4-1964 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, T., ; Rao, C., ; Otto, R., ; Schöning, Michael Josef, schoening@fh-aachen.de „All-in-one" solid-state device based on a lightaddressable potentiometric sensor platform Piscataway, NJ IEEE Operations Center 2005 3 Transducers '05 : the 13th International Conference on Solid-State Sensors, Actuators and Microsystems ; Seoul, Korea, [June 5 - 9, 2005] ; digest of technical papers / sponsored by Korean Sensors Society. Technical co-sponsors: IEEE Electron Devices Society 0-7803-83995-6 International Conference on Solid State Sensors, Actuators and Microsystems ; (13, 2005, Seoul) 1872 1875 Fachbereich Medizintechnik und Technomathematik OPUS4-6841 Konferenzveröffentlichung Wagner, Torsten, torsten.wagner@fh-aachen.de; Yoshinobu, T., ; Otto, R., ; Rao, C., ; Molina, R., ; Schöning, Michael Josef, schoening@fh-aachen.de Licht-adressierbare potentiometrische Sensorsysteme - Konzepte und Anwendungen Berlin VDE Verl. 2006 630 S., + 1 CD-ROM Sensoren und Mess-Systeme 2006 : Vorträge der 13. ITG/GMA-Fachtagung vom 13. bis 14.3.2006 in Freiburg/Breisgau 3-8007-2939-3 165 168 Fachbereich Medizintechnik und Technomathematik OPUS4-4272 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-Ichiro, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging 2012 5 Sensors and Actuators B: Chemical. 170 (2012) 0925-4005 Eurosensors XXIV, 2010 34 39 campus http://dx.doi.org/10.1016/j.snb.2010.12.003 Fachbereich Medizintechnik und Technomathematik OPUS4-4368 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-Ichiro, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, A high-density multi-point LAPS set-up using a VCSEL array and FPGA control Amsterdam Elsevier 2011 4 Sensors and Actuators B: Chemical. 154 (2011), H. 2 1873-3077 EUROSENSORS XXIII 124 128 campus http://dx.doi.org/10.1016/j.snb.2010.03.009 Fachbereich Medizintechnik und Technomathematik OPUS4-4218 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Ackermann, Hans-Josef, h-j.ackermann@fh-aachen.de; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de FPGA-based LAPS device for the flexible design of sensing sites on functional interfaces 2010 5 Physica Status Solidi (A). 207 (2010), H. 4 1862-6300 Special Issue: Engineering of Functional Interfaces EnFI 2009 844 849 campus http://dx.doi.org/10.1002/pssa.200983320 Fachbereich Medizintechnik und Technomathematik OPUS4-3984 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Werner, Frederik, f.werner@fh-aachen.de; Miyamoto, K., ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, T., A high-density multi-point LAPS set-up using a VCSEL array and FPGA control Amsterdam Elsevier 2009 3 Procedia Chemistry. 1 (2009), H. 1 1876-6196 Proceedings of the Eurosensors XXIII conference ; Eurosensors 23 1483 1486 campus http://dx.doi.org/10.1016/j.proche.2009.07.370 Fachbereich Medizintechnik und Technomathematik OPUS4-7800 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Vornholt, Wolfgang, ; Werner, Frederik, f.werner@fh-aachen.de; Yoshinobu, Tatsuo, ; Miyamoto, Ko-Ichiro, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensor (LAPS) combined with magnetic beads for pharmaceutical screening The light-addressable potentiometric sensor (LAPS) has the unique feature to address different regions of a sensor surface without the need of complex structures. Measurements at different locations on the sensor surface can be performed in a common analyte solution, which distinctly simplifies the fluidic set-up. However, the measurement in a single analyte chamber prevents the application of different drugs or different concentrations of a drug to each measurement spot at the same time as in the case of multi-reservoir-based set-ups. In this work, the authors designed a LAPS-based set-up for cell culture screening that utilises magnetic beads loaded with the endotoxin (lipopolysaccharides, LPS), to generate a spatially distributed gradient of analyte concentration. Different external magnetic fields can be adjusted to move the magnetic beads loaded with a specific drug within the measurement cell. By recording the metabolic activities of a cell layer cultured on top of the LAPS surface, this work shows the possibility to apply different concentrations of a sample along the LAPS measurement spots within a common analyte solution. 2016 5 Physics in medicine 2016 1 2 7 10.1016/j.phmed.2016.03.001 weltweit https://doi.org/10.1016/j.phmed.2016.03.001 Fachbereich Medizintechnik und Technomathematik OPUS4-4948 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Shigiahara, N., ; Miyamoto, K., ; Suzurikawa, J., ; Finger, F., ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, T., Light-addressable Potentiometric Sensors and Light-addressable Electrodes as a Combined Sensor-and-manipulator Microsystem with High Flexibility This work describes the novel combination of the light-addressable electrode (LAE) and the light-addressable potentiometric sensor (LAPS) into a microsystem set-up. Both the LAE as well as the LAPS shares the principle of addressing the active spot by means of a light beam. This enables both systems to manipulate resp. to detect an analyte with a high spatial resolution. Hence, combining both principles into a single set-up enables the active stimulation e.g., by means of electrolysis and a simultaneous observation e.g., the response of an entrapped biological cell by detection of extracellular pH changes. The work will describe the principles of both technologies and the necessary steps to integrate them into a single set-up. Furthermore, examples of application and operation of such systems will be presented. Amsterdam Elsevier 2012 3 Procedia Engineering Part of special issue "26th European Conference on Solid-State Transducers, EUROSENSOR 2012" 47 890 893 10.1016/j.proeng.2012.09.290 campus https://doi.org/10.1016/j.proeng.2012.09.290 Fachbereich Medizintechnik und Technomathematik OPUS4-1756 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Otto, R., ; Yoshinobu, T., A handheld 16 channel pen-type LAPS as a platform for (bio-)electrochemical sensing 2004 1 Biomedizinische Technik. 49 (2004), H. 2 0932-4666 996 997 Fachbereich Medizintechnik und Technomathematik OPUS4-3443 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Light-addressable potentiometric sensors (LAPS): recent trends and applications Amsterdam Elsevier 2007 LIV, 974 S. + 1 CD-ROM Electrochemical sensor analysis / edited by S. Alegret ... 978-0-444-53053-0 Wilson & Wilson's comprehensive analytical chemistry ; 49 87 128 Fachbereich Medizintechnik und Technomathematik OPUS4-1794 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Rao, C., ; Otto, R., ; Yoshinobu, T., ; Kloock, Joachim P., ; Schöning, Michael Josef, schoening@fh-aachen.de Chipkarten-basierter Multikanal lichtadressierbarer potentiometrischer Sensor für analytische Anwendungen in flüssigen Medien Dresden TUDpress 2005 313 S Neue Herausforderungen und Anwendungen in der Sensortechnik : 7. Dresdner Sensor-Symposium ; 12. - 14. Dezember 2005, Dresden / [Forschungsgesellschaft für Messtechnik, Sensorik und Medizintechnik e.V.]. Gerald Gerlach ... (Hg.) 3-938863-29-3 Dresdner Beiträge zur Sensorik ; 24 11 14 Fachbereich Medizintechnik und Technomathematik OPUS4-3053 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Rao, C., ; Kloock, Joachim P., kloock@fh-aachen.de; Yoshinobu, T., ; Otto, R., ; Keusgen, M., ; Schöning, Michael Josef, schoening@fh-aachen.de "LAPS Card"—A novel chip card-based light-addressable potentiometric sensor (LAPS) 2006 7 Sensors and Actuators B: Chemical. 118 (2006), H. 1-2 0925-4005 Eurosensors XIX - Eurosensors XIX - The 19th European Conference on Solid-State Transducers 33 40 campus http://dx.doi.org/10.1016/j.snb.2006.04.019 Fachbereich Medizintechnik und Technomathematik OPUS4-3249 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Molina, Roberto, ; Yoshinobu, Tatsuo, ; Kloock, Joachim P., kloock@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Canzoneri, Michele, canzoneri@fh-aachen.de; Schnitzler, Thomas, schnitzler@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications 2007 6 Electrochimica Acta. 53 (2007), H. 2 0013-4686 305 311 campus http://dx.doi.org/10.1016/j.electacta.2007.04.006 Fachbereich Chemie und Biotechnologie OPUS4-3453 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Molina, R., ; Biselli, Manfred, biselli@fh-aachen.de; Canzoneri, Michele, canzoneri@fh-aachen.de; Schnitzler, Thomas, schnitzler@fh-aachen.de; Yoshinobu, Tatsuo, ; Schöning, Michael Josef, schoening@fh-aachen.de A light-addressable potentiometric sensor system for fast, simultaneous and spatial detection of the metabolic activity of biological cells Piscataway IEEE 2007 3 Transducers '07 Eurosensors XXI : digest of technical papers ; the14th International Conference on Solid-State Sensors, Actuators and Microsystems, June 10-14, 2007, Lyon, France / Gilles Delapierre (Ed.) 1-4244-0841-5 Eurosensors 21, 2007, Lyon ; International Conference on Solid-State Sensors, Actuators and Microsystems 14, 2007, Lyon 1107 1110 campus http://dx.doi.org/10.1109/SENSOR.2007.4300328 Fachbereich Chemie und Biotechnologie OPUS4-4614 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Shigihara, Noriko, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Microfluidic systems with free definable sensor spots by an integrated light-addressable potentiometric sensor Amsterdam Elsevier 2011 3 Procedia Engineering. 25 (2011) 1877-7058 EurosensorsXXV ; Proc. Eurosensors XXV, September 4-7, 2011, Athens, Greece 791 794 campus http://dx.doi.org/10.1016/j.proeng.2011.12.194 Fachbereich Medizintechnik und Technomathematik OPUS4-4384 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, Ko-ichiro, ; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, Tatsuo, Novel combination of digital light processing (DLP) and light-addressable potentiometric sensors (LAPS) for flexible chemical imaging 2010 3 Procedia Engineering. 5 (2010) 1877-7058 Eurosensor XXIV Conference 520 523 campus http://dx.doi.org/10.1016/j.proeng.2010.09.161 Fachbereich Medizintechnik und Technomathematik OPUS4-4484 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Miyamoto, K., ; Werner, Frederik, f.werner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Yoshinobu, T., Flexible electrochemical imaging with "zoom-in" functionality by using a new type of light-addressable potentiometric sensor New York IEEE 2011 2 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference (TRANSDUCERS) , Date: 5-9 June 2011 2133 2135 campus http://dx.doi.org/10.1109/TRANSDUCERS.2011.5969294 Fachbereich Medizintechnik und Technomathematik OPUS4-3446 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Maris, Rob J., ; Ackermann, Hans-Josef, h-j.ackermann@fh-aachen.de; Otto, Ralph, ; Beging, Stefan, beging@fh-aachen.de; Poghossian, Arshak, poghossian@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Handheld measurement device for field-effect sensor structures: Practical evaluation and limitations 2007 6 Sensors and Actuators B: Chemical . 127 (2007), H. 1 0925-4005 217 223 campus http://dx.doi.org/10.1016/j.snb.2007.07.073 Fachbereich Medizintechnik und Technomathematik OPUS4-3444 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Kloock, Joachim P., kloock@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Determination of cadmium concentration and pH value in aqueous solutions by means of a handheld light-addressable potentiometric sensor (LAPS) device Amsterdam Elsevier 2007 CD-ROM Electrochemical sensor analysis / edited by S. Alegret ... 978-0-444-53133-9 Wilson & Wilson's comprehensive analytical chemistry ; 49 e35 e44 Fachbereich Medizintechnik und Technomathematik OPUS4-1550 Wissenschaftlicher Artikel Wagner, Torsten, torsten.wagner@fh-aachen.de; Beging, Stefan, beging@fh-aachen.de; Rotter, L., ; Poghossian, Arshak, poghossian@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Zang, Werner, zang@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Online-Messsysteme für die automatisierte Charakterisierung von feldeffektbasierten Biosensoren Dresden TUDpress, Verl. der Wissenschaften 2007 343 S. : Ill., graph. Darst. 8. Dresdner Sensor-Symposium : Sensoren für Umwelt, Klima und Sicherheit, Biosensoren und Biosysteme, Sensoren und Sensorsysteme für die Prozesstechnik, Trends in der Sensortechnik, Materialentwicklung für die Sensorik; 8. Dresdner Sensor-Symposium, 10. - 12. Dezember 2007, Dresden / Gerald Gerlach ... (Hg.) 978-3-940046-45-1 Dresdner Sensor-Symposium <8, 2007, Dresden> ; Dresdner Beiträge zur Sensorik ; 29 257 260 Fachbereich Chemie und Biotechnologie OPUS4-6502 Wissenschaftlicher Artikel Wagner, Patrick, ; Doll, Theodor, ; Schöning, Michael Josef, schoening@fh-aachen.de Engineering of functional interfaces / Patrick Wagner ; Theodor Doll ; Michael J. Schöning (eds.) Weinheim Wiley-VCH 2014 0 Physica status solidi (A) : Applications and materials science 211 6 1339 1339 10.1002/pssa.201470241 campus https://doi.org/10.1002/pssa.201470241 Fachbereich Medizintechnik und Technomathematik OPUS4-5986 Wissenschaftlicher Artikel Voigt, Birgit, ; Schroeter, Rebecca, ; Jürgen, Britta, ; Albrecht, Dirk, ; Evers, Stefan, ; Bongaerts, Johannes, bongaerts@fh-aachen.de; Maurer, Karl-Heinz, ; Schweder, Thomas, ; Hecker, Michael, The response of Bacillus licheniformis to heat and ethanol stress and the role of the SigB regulon Weinheim Wiley 2013 6 Proteomics Vol. 13 Iss. 14 2140 2146 campus http://dx.doi.org/10.1002/pmic.201200297 Fachbereich Chemie und Biotechnologie OPUS4-7331 Wissenschaftlicher Artikel Voigt, Birgit, ; Albrecht, Dirk, ; Sievers, Susanne, ; Becher, Dörte, ; Bongaerts, Johannes, bongaerts@fh-aachen.de; Evers, Stefan, ; Schweder, Thomas, ; Maurer, Karl-Heinz, ; Hecker, Michael, High-resolution proteome maps of Bacillus licheniformis cells growing in minimal medium Weinheim Wiley 2015 4 Proteomics 15 15 2629 2633 10.1002/pmic.201400504 campus Fachbereich Chemie und Biotechnologie OPUS4-1796 Wissenschaftlicher Artikel Vlasov, Y. G., ; Mourzina, Y. G., ; Legin, A. V., ; Ermelenko, Y. E., ; Schubert, J., ; Schöning, Michael Josef, schoening@fh-aachen.de; Lüth, H., Solid-state thin film sensors based on chalcogenide materials prepared by planar technology and pulsed laser deposition 2002 5 Russian Journal of Applied Chemistry. 75 (2002), H. 3 1070-4272 351 356 campus http://dx.doi.org/10.1023/A:1016113931292 Fachbereich Medizintechnik und Technomathematik OPUS4-2384 Wissenschaftlicher Artikel Vitusevich, S. A., ; Förster, Arnold, foerster@fh-aachen.de; Reetz, W., ; Lüth, H., ; Belyaev, A. E., ; Danylyuk, S. V., Spectral Responsivity of single-quantum-well photodetectors 2000 2 Applied Physics Letters. 77 (2000), H. 1 1077-3118 16 18 campus http://dx.doi.org/10.1063/1.126862 Fachbereich Energietechnik OPUS4-2430 Wissenschaftlicher Artikel Vitusevich, S. A., ; Förster, Arnold, foerster@fh-aachen.de; Reetz, W., ; Lüth, H., ; Belyaev, A. E., ; Danylyuk, S. V., Fine structure of photoresponse spectra in a double-barrier resonant tunnelling diode 2000 3 Nanotechnology. 11 (2000), H. 4 1361-6528 305 308 campus http://dx.doi.org/10.1088/0957-4484/11/4/322 Fachbereich Energietechnik OPUS4-2403 Wissenschaftlicher Artikel Vitusevich, S. A., ; Förster, Arnold, foerster@fh-aachen.de; Lüth, H., ; Belyaev, A. E., ; Danylyuk, S. V., ; Konakova, R. V., ; Sheka, D. I., Resonant spectroscopy of electric-field-induced superlattices 2001 4 Journal of Applied Physics. 90 (2001), H. 6 1089-7550 2857 2861 10.1063/1.1392956 campus http://scitation.aip.org/getpdf/servlet/GetPDFServlet?filetype=pdf&id=JAPIAU000090000006002857000001&idtype=cvips Fachbereich Energietechnik OPUS4-2387 Wissenschaftlicher Artikel Vitusevich, S. A., ; Förster, Arnold, foerster@fh-aachen.de; Indlekofer, K.-M., ; Lüth, H., ; Belyaev, A. E., ; Glavin, B. A., ; Konakova, R. V., Tunneling Through X-Valley-Related Impurity States in GaAs/AlAs Resonant-Tunneling Diodes 2000 6 Physical Review . B. 61 (2000), H. 16 1550-235X 10898 10904 bezahl http://dx.doi.org/10.1103/PhysRevB.61.10898 Fachbereich Energietechnik OPUS4-8406 Wissenschaftlicher Artikel Vahidpour, Farnoosh, vahidpour@fh-aachen.de; Oberländer, Jan, oberlaender@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Flexible Calorimetric Gas Sensors for Detection of a Broad Concentration Range of Gaseous Hydrogen Peroxide: A Step Forward to Online Monitoring of Food-Package Sterilization Processes In this study, flexible calorimetric gas sensors are developed for specificdetection of gaseous hydrogen peroxide (H₂O₂) over a wide concentrationrange, which is used in sterilization processes for aseptic packaging industry.The flexibility of these sensors is an advantage for identifying the chemical components of the sterilant on the corners of the food boxes, so-called "coldspots", as critical locations in aseptic packaging, which are of great importance. These sensors are fabricated on flexible polyimide films by means of thin-film technique. Thin layers of titanium and platinum have been deposited on polyimide to define the conductive structures of the sensors. To detect the high-temperature evaporated H₂O₂, a differential temperature set-up is proposed. The sensors are evaluated in a laboratory-scaled sterilizationsystem to simulate the sterilization process. The concentration range of the evaporated H₂O₂ from 0 to 7.7% v/v was defined and the sensors have successfully detected high as well as low H₂O₂ concentrations with a sensitivity of 5.04 °C/% v/v. The characterizations of the sensors confirm their precise fabrication, high sensitivity and the novelty of low H₂O₂ concentration detections for future inline monitoring of food-package sterilization. Weinheim Wiley-VCH 2018 7 Seiten Phys. Status Solidi A 215 15 Article number 1800044 10.1002/pssa.201800044 bezahl https://onlinelibrary.wiley.com/doi/abs/10.1002/pssa.201800044 Fachbereich Medizintechnik und Technomathematik OPUS4-10462 Wissenschaftlicher Artikel Vahidpour, Farnoosh, ; Guthman, Eric, ; Arreola, Julia, ; Alghazali, Yousef H. M., ; Wagner, Torsten, ; Schöning, Michael Josef, Assessment of Various Process Parameters for Optimized Sterilization Conditions Using a Multi-Sensing Platform In this study, an online multi-sensing platform was engineered to simultaneously evaluate various process parameters of food package sterilization using gaseous hydrogen peroxide (H₂O₂). The platform enabled the validation of critical aseptic parameters. In parallel, one series of microbiological count reduction tests was performed using highly resistant spores of B. atrophaeus DSM 675 to act as the reference method for sterility validation. By means of the multi-sensing platform together with microbiological tests, we examined sterilization process parameters to define the most effective conditions with regards to the highest spore kill rate necessary for aseptic packaging. As these parameters are mutually associated, a correlation between different factors was elaborated. The resulting correlation indicated the need for specific conditions regarding the applied H₂O₂ gas temperature, the gas flow and concentration, the relative humidity and the exposure time. Finally, the novel multi-sensing platform together with the mobile electronic readout setup allowed for the online and on-site monitoring of the sterilization process, selecting the best conditions for sterility and, at the same time, reducing the use of the time-consuming and costly microbiological tests that are currently used in the food package industry. Basel MDPI 2022 16 Seiten Foods 11 This article belongs to the Special Issue "Sensors and Biosensors Application for Food Industries" 5 10.3390/foods11050660 weltweit https://doi.org/10.3390/foods11050660 INB - Institut für Nano- und Biotechnologien OPUS4-10454 Wissenschaftlicher Artikel Vahidpour, Farnoosh, vahidpour@fh-aachen.de; Alghazali, Yousef, ; Akca, Sevilay, ; Hommes, Gregor, ; Schöning, Michael Josef, schoening@fh-aachen.de An Enzyme-Based Interdigitated Electrode-Type Biosensor for Detecting Low Concentrations of H₂O₂ Vapor/Aerosol This work introduces a novel method for the detection of H₂O₂ vapor/aerosol of low concentrations, which is mainly applied in the sterilization of equipment in medical industry. Interdigitated electrode (IDE) structures have been fabricated by means of microfabrication techniques. A differential setup of IDEs was prepared, containing an active sensor element (active IDE) and a passive sensor element (passive IDE), where the former was immobilized with an enzymatic membrane of horseradish peroxidase that is selective towards H₂O₂. Changes in the IDEs' capacitance values (active sensor element versus passive sensor element) under H₂O₂ vapor/aerosol atmosphere proved the detection in the concentration range up to 630 ppm with a fast response time (<60 s). The influence of relative humidity was also tested with regard to the sensor signal, showing no cross-sensitivity. The repeatability assessment of the IDE biosensors confirmed their stable capacitive signal in eight subsequent cycles of exposure to H₂O₂ vapor/aerosol. Room-temperature detection of H₂O₂ vapor/aerosol with such miniaturized biosensors will allow a future three-dimensional, flexible mapping of aseptic chambers and help to evaluate sterilization assurance in medical industry. Basel MDPI 2022 18 Seiten Chemosensors 10 This article belongs to the Special Issue "Bioinspired Chemical Sensors and Micro-Nano Devices" 6 10.3390/chemosensors10060202 https://doi.org/10.3390/chemosensors10060202 INB - Institut für Nano- und Biotechnologien OPUS4-3775 Wissenschaftlicher Artikel Turek, Monika, ; Schöning, Michael Josef, schoening@fh-aachen.de; Kloock, Joachim P., kloock@fh-aachen.de; Schubert, Jürgen, ; Zander, Willi, ; Krüger, Peter, ; Keusgen, Michael, Herstellung und Charakterisierung eines hybriden Sensorarrays auf Halbleiterbasis für die Umweltanalytik Düsseldorf VDI-Verl. 2008 956 S. : Ill., graph. Darst. + 1 CD-ROM Sensoren und Messsysteme 2008 : 14. Fachtagung Ludwigsburg, 11. und 12. März 2008 / VDI/VDE-Gesellschaft Mess- und Automatisierungstechnik 978-3-18-092011-5 VDI-Berichte ; 2011 ; Sensoren und Messsysteme 2008, 14. GMA/ITG-Fachtagung, VDI/VDE- Gesellschaft Mess- und Automatisierungstechnik, + CD-ROM, Ludwigsburg, DE, 11.-12. Mar, 2008 803 810 Fachbereich Medizintechnik und Technomathematik OPUS4-3244 Wissenschaftlicher Artikel Turek, Monika, ; Ketterer, Lothar, ; Claßen, Melanie, melanie.classen@fh-aachen.de; Berndt, Heinz, h.berndt@fh-aachen.de; Elbers, Gereon, elbers@fh-aachen.de; Krüger, Peter, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Development and Electrochemical Investigations of an EIS-(Electrolyte-Insulator-Semiconductor) based Biosensor for Cyanide Detection 2007 11 Sensors 7 1424-8220 8 1415 1426 weltweit http://dx.doi.org/10.3390/s7081415 Fachbereich Chemie und Biotechnologie OPUS4-3969 Wissenschaftlicher Artikel Turek, Monik, ; Heiden, Wolfgang, ; Guo, Sharon, ; Riesen, Alfred, ; Schubert, Jürgen, ; Zander, Willi, ; Krüger, Peter, ; Keusgen, Michael, ; Schöning, Michael Josef, schoening@fh-aachen.de Simultaneous detection of cyanide and heavy metals for environmental analysis by means of µISEs 2010 6 Physica Status Solidi (A). 207 (2010), H. 4 1862-6300 Special Issue: Engineering of Functional Interfaces EnFI 2009 817 823 campus http://dx.doi.org/10.1002/pssa.200983303 Fachbereich Medizintechnik und Technomathematik OPUS4-3784 Wissenschaftlicher Artikel Turek, M., ; Keusgen, M., ; Poghossian, Arshak, poghossian@fh-aachen.de; Mulchandani, A., ; Wang, J., ; Schöning, Michael Josef, schoening@fh-aachen.de Enzyme-modified electrolyte-insulator-semiconductor sensors 2008 3 Journal of Contemporary Physics. 43 (2008), H. 2 1934-9378 Armenian Academy of Sciences 82 85 campus http://link.springer.com/content/pdf/10.1007%2Fs11958-008-2007-9 Fachbereich Medizintechnik und Technomathematik OPUS4-2383 Wissenschaftlicher Artikel Tillmann, K., ; Förster, Arnold, foerster@fh-aachen.de Critical dimensions for the formation of interfacial misfit dislocations of In0.6Ga0.4As islands on GaAs(001) 2000 11 Thin Solid Films. 368 (2000), H. 1 0040-6090 93 104 campus http://dx.doi.org/10.1016/S0040-6090(00)00858-0 Fachbereich Energietechnik OPUS4-1766 Wissenschaftlicher Artikel Thust, Marion, ; Mulchandani, Ashok, ; Wang, Joseph, ; Arzdorf, Michael, ; Mulchandani, Priti, ; Chen, Wilfried, ; Schöning, Michael Josef, schoening@fh-aachen.de Feldeffekt-Enzymsensor zur Detektion von Pestiziden 2003 3 Technisches Messen. 70 (2003), H. 12 0171-8096 561 564 bezahl http://dx.doi.org/10.1524/teme.70.12.561.20265 Fachbereich Medizintechnik und Technomathematik OPUS4-1683 Wissenschaftlicher Artikel Thust, M., ; Schöning, Michael Josef, schoening@fh-aachen.de; Muchandani, A., ; Wang, J., ; Arzdorf, M., ; Mulchandani, P., ; Chen, W., Feldeffekt-Enzymsensor zur Detektion von Pestiziden Dresden w.e.b.-Univ.-Verl. 2003 343 S : Ill., graph. Darst ; 23 cm Sensoren für zukünftige Hochtechnologien und Neuentwicklungen für die Verfahrenstechnik / 6. Dresdner Sensor-Symposium, 8. - 10. Dezember 2003, Dresden. Jörg Peter Baselt; Gerald Gerlach (Hg.) 3-935712-92-8 125 128 Fachbereich Medizintechnik und Technomathematik OPUS4-6836 Konferenzveröffentlichung Takenaga, Shoko, ; Werner, Frederik, f.werner@fh-aachen.de; Sawada, Kazuaki, ; Schöning, Michael Josef, schoening@fh-aachen.de Comparison of label-free ACh image sensors based on CCD and LAPS 2012 3 978-3-9813484-2-2 14th International Meeting on Chemical Sensors - IMCS 2012 356 359 10.5162/IMCS2012/4.2.6 weltweit Fachbereich Medizintechnik und Technomathematik OPUS4-7291 Wissenschaftlicher Artikel Takenaga, Shoko, takenaga@fh-aachen.de; Schneider, Benno, benno.schneider@fh-aachen.de; Erbay, E., ; Biselli, Manfred, biselli@fh-aachen.de; Schnitzler, Thomas, schnitzler@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Fabrication of biocompatible lab-on-chip devices for biomedical applications by means of a 3D-printing process Weinheim Wiley 2015 5 Physica status solidi (a) 212 6 1347 1352 10.1002/pssa.201532053 Fachbereich Chemie und Biotechnologie OPUS4-6111 Konferenzveröffentlichung Takenaga, Shoko, takenaga@fh-aachen.de; Herrera, Cony F., ; Werner, Frederik, f.werner@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Schnitzler, Thomas, schnitzler@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de; Öhlschläger, Peter, oehlschlaeger@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de Detection of the metabolic activity of cells by differential measurements based on a single light-addressable potentiometric sensor chip 2013 4 11. Dresdner Sensor-Symposium : 9.-11.12.2013 978-3-9813484-5-3 63 67 weltweit http://dx.doi.org/10.5162/11dss2013/3.4 Fachbereich Chemie und Biotechnologie OPUS4-6441 Wissenschaftlicher Artikel Takenaga, Shoko, takenaga@fh-aachen.de; Biselli, Manfred, biselli@fh-aachen.de; Schnitzler, Thomas, schnitzler@fh-aachen.de; Öhlschläger, Peter, oehlschlaeger@fh-aachen.de; Wagner, Torsten, torsten.wagner@fh-aachen.de; Schöning, Michael Josef, schoening@fh-aachen.de Toward multi-analyte bioarray sensors: LAPS-based on-chip determination of a Michaelis-Menten-like kinetics for cell culturing The metabolic activity of Chinese hamster ovary (CHO) cells was observed using a light-addressable potentiometric sensor (LAPS). The dependency toward different glucose concentrations (17-200 mM) follows a Michaelis-Menten kinetics trajectory with Kₘ = 32.8 mM, and the obtained Kₘ value in this experiment was compared with that found in literature. In addition, the pH shift induced by glucose metabolism of tumor cells transfected with the HPV-16 genome (C3 cells) was successfully observed. These results indicate the possibility to determine the tumor cells metabolism with a LAPS-based measurement device. Weinheim Wiley-VCH 2014 5 Physica status solidi A : Applications and materials science 211 6 1410 1415 10.1002/pssa.201330464 campus https://doi.org/10.1002/pssa.201330464 Fachbereich Chemie und Biotechnologie OPUS4-2404 Wissenschaftlicher Artikel Stock, J., ; Malindretos, J., ; Indlekofer, K.M., ; Pöttgens, Michael, ; Förster, Arnold, foerster@fh-aachen.de; Lüth, Hans, A Vertical Resonant Tunneling Transistor for Application in Digital Logic Circuits 2001 4 IEEE Transactions on Electron Devices (T-ED). 48 (2001), H. 6 0018-9383 1028 1032 campus http://dx.doi.org/10.1109/16.925221 Fachbereich Energietechnik OPUS4-2932 Wissenschaftlicher Artikel Srnanek, R., ; Geurts, J., ; Lentze, M., ; Irmer, G., ; Donoval, D., ; Brdecka, P., ; Kordos, P., ; Förster, Arnold, foerster@fh-aachen.de; Sciana, B., ; Radziewicz, D., ; Tlaczala, M., Study of d-doped GaAs layers by micro-Raman spectroscopy on bevelled samples 2004 6 Applied surface science . 230 (2004), H. 1 -4 0169-4332 ISSN der E-Ausg.: 0169-4332 379 385 campus http://dx.doi.org/10.1016/j.apsusc.2004.02.056 Fachbereich Energietechnik OPUS4-4663 Wissenschaftlicher Artikel Spiess, Elmar, ; Wilfried, Reichardt, ; Alvarez, Gerardo, ; Gottrup, Marcus, ; Öhlschläger, Peter, oehlschlaeger@fh-aachen.de An Artificial PAP Gene Breaks Self-tolerance and Promotes Tumor Regression in the TRAMP Model for Prostate Carcinoma Amsterdam Elsevier 2011 9 Molecular Therapy 20 1525-0016 3 555 564 bezahl http://dx.doi.org/10.1038/mt.2011.241 Fachbereich Chemie und Biotechnologie OPUS4-6843 Wissenschaftlicher Artikel Spelthahn, Heiko, ; Schubert, Jürgen, ; Schöning, Michael Josef, schoening@fh-aachen.de Dünnschichtsensoren für die Schwermetallanalytik : Mikroelektroden auf Chalkogenidglasbasis Die Detektion von Schadstoffen repräsentiert in der Umweltanalytik eine wichtige Aufgabenstellung. Gerade die Abwasser- bzw. Brauchwasseranalytik sowie die Prozesskontrolle haben einen hohen Stellenwert. Siliziumbasierte Dünnschichtsensoren bieten eine kostengünstige Möglichkeit, „online"-Messungen bzw. Vor-Ort-Messungen zeitnah durchzuführen. In dieser Arbeit wird ein potentiometrisches Sensorarray auf der Basis von Chalkogenidgläsern zur Detektion von Schwermetallen in wässrigen Medien vorgestellt. Weinheim Wiley-VCH 2012 2 GIT Labor-Fachzeitschrift 4 285 287 weltweit http://www.git-labor.de/forschung/umwelt/duennschichtsensoren-fuer-die-schwermetallanalytik?page=1 Fachbereich Medizintechnik und Technomathematik